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Results for " GM " 4,884 found 🔀 AI-powered Shuffle

Brendan Shanahan Floated as Red Wings’ Next GM

Brendan Shanahan is back in the Red Wings GM conversation, and the timing is not an accident. #RedWings

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Sep 10 • 5:20 PM EDT • Sports • sports.yahoo.com
Minnesota-Mississippi State score predictions from Bring Me The Sports staff

The Gophers face a big test in Week 2 against the Bulldogs.

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Sep 10 • 4:54 PM EDT • Sports • sports.yahoo.com
iPhone Duo could give Apple a 25% share of foldable market in 2026

TrendForce says the iPhone Duo is expected to capture 24,8% of the foldable smartphone market in 2026 alone, countering a 20% slump in the segment.

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Sep 10 • 4:04 PM EDT • Technology • 9to5mac.com
T-Pain Sues Konvict Entertainment for $489K in Unpaid Royalties, Alleges Contract Breach

T-Pain has filed a lawsuit against Konvict Entertainment in Fulton County Superior Court, seeking $489,047.76 in allegedly unpaid royalties, prejudgment interest, and attorney fees. The complaint, filed on Friday, Sept….

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Sep 10 • 3:58 PM EDT • Entertainment • foxy99.com
Snoop Dogg brings the VMAs back to Los Angeles as host for Sept. 27 show

The MTV Video Music Awards are returning to the West Coast with Snoop Dogg as host.

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Sep 10 • 1:58 PM EDT • Entertainment • wsls.com
Scientists May Have Cracked the Mystery of the Moon’s Unequal Hemispheres

Chang’e-6 samples suggest the Moon’s two very different sides may have formed when uneven heating drove magma from one hemisphere to the other. The Moon presents two dramatically different faces. Its Earth-facing hemisphere is rich in dark volcanic plains, while the farside is dominated by older highlands and a much thicker crust. New analyses of

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Sep 10 • 1:49 PM EDT • Science • scitechdaily.com
Kimmel says interview with James Talarico won't air on TV under pressure from the FCC

Jimmy Kimmel says the federal agency regulating television has "threatened" his show.

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Sep 10 • 1:12 PM EDT • Entertainment • ksat.com
Carlisle Benefits From Business Strength, Risks Persist

CSL gains from strong construction demand, segment growth and shareholder returns, though rising costs, margin pressure and debt pose risks.

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Sep 10 • 12:26 PM EDT • Business • finance.yahoo.com
Apple Watch Series 12 Has Smaller Screens and Bigger Cases

The Apple Watch Series 12 pairs a smaller display with a wider case than Series 10 and Series 11, even though the pixel resolution hasn't changed, according to Apple's own tech specs. For the 46mm Series 12, Apple's tech specs page lists the display area at 1,196 sq mm, down 2% from 1,220 sq mm on Series 10 and Series 11. The 42mm size shows a similar 1.9% drop, from 989 sq mm to 970 sq mm.

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Sep 10 • 11:52 AM EDT • Technology • macrumors.com
Redding receives nearly $8 million grant for Stillwater Business Park improvements

The grant will go toward extending a portion of the park to allow for the opening of additional parcels for future development.

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Sep 10 • 11:31 AM EDT • Business • shastascout.org
Chubb Limited's Life Business Emerges as a Key Growth Engine

CB's Life segment is emerging as a second earnings engine, fueled by international growth, employee benefits and recurring premiums.

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Sep 10 • 11:05 AM EDT • Business • finance.yahoo.com
Kings of Leon reveal a new more personal, acoustic songwriting direction with album 'O My Beloved'

Kings of Leon are returning with a new album, “O My Beloved,” which marks a sonic shift for the band.

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Sep 10 • 11:01 AM EDT • Entertainment • ksat.com
Canada's major General Contractors unite to raise awareness about mental health problems and illnesses and prevent suicide across the construction industry

This September, during National Suicide Prevention Month, the Canadian Construction Safety Council (CCSC) is launching an industry-wide suicide prevention campaign Looking Out For Each Other to raise awareness, reduce stigma and help construction workers, supervisors and leaders recognize that mental health is essential to a safer industry.

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Sep 10 • 11:00 AM EDT • Health • finance.yahoo.com
What Would Charlie Kirk Do Today?

A year after the killing of the 31-year-old conservative youth leader, the movement he helped create has splintered. Would that be the case if he were still alive?

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Sep 10 • 10:56 AM EDT • Politics • nytimes.com
SPONSORED SEGMENT: Dees Integrative Health

Peripheral Neuropathy workshop

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Sep 10 • 10:45 AM EDT • Health • mysuncoast.com
Report: Red Wings Eliminate Another Candidate from GM Contention

A new report says Shawn Horcoff is not a finalist for the Red Wings GM job as Detroit's search continues with camp approaching.

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Sep 10 • 9:52 AM EDT • Sports • sports.yahoo.com
Little Mercury may be shrinking faster than scientists expected

A new study shows that little, wrinkly Mercury may be shrinking faster than expected.

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Sep 10 • 9:00 AM EDT • Science • news4jax.com
Little Mercury may be shrinking faster than scientists expected

A new study shows that little, wrinkly Mercury may be shrinking faster than expected.

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Sep 10 • 9:00 AM EDT • Science • wsls.com
Pigment launches AI-generated interfaces to broaden business planning

Pigment launches AI-generated interfaces to broaden business planning - SiliconANGLE

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Sep 10 • 9:00 AM EDT • Business • siliconangle.com
Scientists create brilliant white material without a drop of white pigment

Researchers have created a foam-based material that produces intense whiteness and water repellency without titanium dioxide pigments or PFAS chemicals. Inspired by natural structures in snow, clouds, flowers, and lotus leaves, the material uses tiny pores to scatter light while its rough surface repels water. The technology could offer a more sustainable way to make white, water-resistant everyday materials.

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Sep 10 • 8:00 AM EDT • Science • sciencedaily.com
Video Billy Joel opens up about his private health battle

The music legend opened up about his recent health battle on his podcast, "The Billy Joel Channel," saying that he underwent brain surgery after being diagnosed with normal pressure hydrocephalus.

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Sep 10 • 8:00 AM EDT • Health • abcnews.com
Video Walking faster may have big health benefits, study finds

The new study found taking faster steps per day in a 30-minute timeframe can be as helpful in lowering the risk of death as taking more steps per day.

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Sep 10 • 8:00 AM EDT • Health • abcnews.com
REWE partnership extended until 2029

Eintracht Frankfurt and REWE Markt GmbH are set to build on their long-standing collaboration.The partnership between Eintracht Frankfurt and REWE, which was first established in 2009, has been extend...

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Sep 10 • 8:00 AM EDT • Sports • sports.yahoo.com
Have scientists finally detected dark matter?

For decades physicists have been puzzling over the enigma of dark matter. We think it makes up 85% of the matter in the universe, but the mysterious substance cannot be seen or detected, and we know about it mainly through observations of the gravitational effects it has on other things. But now scientists believe they may be a step closer to detecting it. Science editor Ian Sample explains to Madeleine Finlay why, if confirmed, the finding could completely transform our understanding of the universe. And Dr Samuel Erikson, senior research associate at the University of Bristol, and first author of the research paper, explains how the finding has been received in the physics community

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Sep 10 • 6:54 AM EDT • Science • theguardian.com
Ali Ruwaih Named VP & GM of TSL Business at Lockheed Martin

Ali Ruwaih has spent more than two decades at Lockheed Martin, working in aviation, radar and international naval programs.

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Sep 10 • 5:52 AM EDT • Business • govconwire.com
Notre Dame College closed two years ago. Where did its employees go?

More than two years after Notre Dame College closed, its former employees have scattered across Northeast Ohio and beyond, with many building new careers in higher education.

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Sep 10 • 5:45 AM EDT • Business • crainscleveland.com
Breaking down the stigma around maternal mental health
Healthcare AI’s next test is integration

While advanced AI excels at processing clinical data, healthcare's true test lies in overcoming deeply fragmented administrative workflows.

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Sep 10 • 4:58 AM EDT • Health • technologyreview.com
As AI transforms science, researchers need far more support

Prospect of AI creating “new scientific paradigm” necessitates big picture responses from across research community

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Sep 10 • 3:00 AM EDT • Science • researchprofessionalnews.com
J-50 design team reveals leapfrog tech for China’s next-gen stealth fighters

The aircraft are expected to have futuristic systems for self-flying and large-scale drone wingman squads.

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Sep 10 • 2:58 AM EDT • Science • scmp.com
'Welcome to Foldables': Samsung braces for Apple's foldable iPhone challenge

Samsung launched a publicity campaign for its foldable phones, touting its hardware advantage and its early entry into the segment.

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Sep 10 • 1:28 AM EDT • Technology • reuters.com
Global heat stuck on high. Scientists say August was Earth's hottest month they've measured.

The European climate service Copernicus said the Earth just sweltered through its hottest month on record in August.

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Sep 9 • 10:00 PM EDT • Science • clickorlando.com
27-year-old man fatally shot inside Detroit business on Woodward Avenue

A 27-year-old man was fatally shot inside a business on Woodward Avenue in Detroit.

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Sep 9 • 9:45 PM EDT • Business • clickondetroit.com
Five Plays: Ole Miss Second Quarter

The Louisville football team held serve with Ole Miss in the first quarter before falling behind in the second. Mistakes continued to plague the team, but a few big plays kept this game close. While the team had great energy on both sides of the ball, this was the segment of the game where they […]

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Sep 9 • 8:56 PM EDT • Sports • sports.yahoo.com
Viewpoint: Unlocking Europe’s wildfire data

Europe is already investing in the science, technology and infrastructure needed to understand, prevent and fight wildfires. Copernicus provides satellite-based Earth observation and environmental information, while the European Forest Fire Information System provides information on fire danger and forest fires across Europe. Weather and climate systems add forecasts of heat, drought, wind and humidity; historical fire databases show where fires have occurred; and researchers generate increasingly detailed knowledge about fuels, fire behaviour, forecasting, modelling and risk management. Meanwhile, new European research projects are adding digital twins and other tools to this growing ecosystem.However, these data do not necessarily sit together, nor are they necessarily described, structured or governed in ways that allow them to be used together. Much of the information is public, but some is commercially held. Some is sensitive. Some is subject to legal, security or operational restrictions. Even when data can be legally accessed, different systems may use different formats, terminology and rules.Europe therefore faces an unusual paradox: we have vast amounts of relevant information to respond to the wildfire challenge, but not the means to bring it together. For example, a wildfire researcher or emergency service might need to ask whether a particular combination of vegetation, drought, wind and topography has historically been associated with rapid fire spread. The relevant information may exist in several institutions, using different systems and subject to different conditions of access.The challenge is to conduct an authorised analysis that interacts with these sources, combines the results and respects the rules imposed by each data custodian.An important part of the answer can be found in the Fair principles, the idea that data should be findable, accessible, interoperable and reusable. Developed more than a decade ago, these principles have become a central reference point for modern data stewardship, making it easier for people and machines to find data, understand what it means and determine whether it can be reused.Readability by machines is essential, since AI systems will be key to meeting the data challenge. Bring analysis to the dataThe proposition is not to give an AI system unrestricted access to sensitive databases. Quite the opposite. The goal is to make it possible for approved algorithms to go to the data, rather than requiring sensitive data or large datasets to be copied to wherever the analysis happens.Imagine an analysis asking a series of questions of different data stations. At one station it might examine weather and climate data; at another, historical fire records; at another, experimental measurements of fire behaviour. The algorithm does not need to download everything. It can operate within the environment permitted by each data custodian and return only the results that the rules allow to leave.This is sometimes described as data visiting, and related approaches already exist in areas such as federated analysis and federated learning.Sensitive data should therefore not be treated as a free-for-all for machines. This requires appropriate governance at multiple levels. Access needs to be authenticated and authorised. The purpose of an analysis should be defined. The code or model being run should be controlled. Data custodians should be able to specify what can be queried and what results can leave their environment. Activities should be auditable and human oversight should remain where the consequences require it.In other words, the objective is not to trust AI with the data. It is to design systems in which AI never has more access than it needs.As open as possible, as closed as necessaryFair data should also not be confused with open data. Some wildfire data should be openly available. Other information may legitimately need to remain restricted because it concerns critical infrastructure, security, commercial interests, privacy or operational capabilities. The principle should be: as open as possible, as closed as necessary.The important point is that restricted data should not automatically become unusable data. If machines can discover what information exists, understand its meaning, establish where it came from and determine the conditions under which it can be used, authorised analyses can potentially be carried out without the underlying data ever leaving the environment in which it is protected.Restricted data can still be Fair and machine-actionable.This is also an important question of data sovereignty. European institutions should not have to surrender control of their data to a handful of technology platforms in order to benefit from AI. Nor does Europe need to start again by building one giant repository for every piece of wildfire information. The better approach is to connect what already exists.This is the principle behind emerging approaches such as Tryangle, developed through the Leiden Initiative for Fair and Equitable Science. Rather than creating another centralised data warehouse, the approach seeks to provide an interoperable layer through which approved algorithms can visit distributed data sources while respecting the rules of their custodians.In this way, a data station can remain where it is. Its custodians can retain control. Existing databases and applications do not have to be abandoned. What changes is their ability to communicate with other systems through common, machine-readable descriptions, access rules and interoperability mechanisms.But approaches like this need data that meets the Fair principles. Only then can an interoperable ecosystem safely begin to turn fragmented information into collective intelligence.Data infrastructure is wildfire infrastructureThe implications of this approach are entirely practical. Firefighters could gain better intelligence about local and evolving risks. Land managers could test prevention strategies using more comprehensive information about fuels, weather and past fires. Researchers could compare evidence across ecosystems without repeatedly moving huge datasets between institutions. Smaller regions and resource-constrained teams could access analytical capabilities without having to build large data infrastructures themselves.Europe is already investing heavily in satellites, databases, research programmes, forecasting systems and scientific expertise. The question is whether we will connect those investments well enough to turn them into actionable intelligence.That requires policymakers and funders to treat data infrastructure as seriously as physical infrastructure. Data generated or supported through European public funding should be Fair, verifiable and machine actionable by design, wherever legally and ethically possible.Related articlesData Corner: Europe’s burning need for wildfire mitigation researchClimate monitoring must remain a global enterprise, experts sayIn practice, that means funding not only the production of data, but also the infrastructure that makes data usable across systems: metadata, provenance, interoperability, access mechanisms and governance. Where data must remain restricted, we should ensure that it can still be securely discovered, verified and used for authorised analysis.Initiatives such as the European Open Science Cloud offer an existing framework through which these principles can be put into practice. What is needed now is to accelerate implementation and make them a standard part of how Europe funds and builds research and innovation systems.We do not need another generation of disconnected databases. The data is already there. The opportunity is to make it work together, securely, responsibly and quickly enough to help prevent the next fire, rather than simply document the last one.Jean-Claude Burgelman is professor emeritus at the Free University of Brussels (VUB) and editor-in-chief at Frontiers Policy Lab. For more than 20 years he held leading roles in research and innovation policy at the European Commission.

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Sep 9 • 8:00 PM EDT • Science • sciencebusiness.net
Local politics limits China’s rare earth leverage

China’s rare earth dominance rests on a fragmented system of ministries, provinces and firms, each pursuing their own interests.

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Sep 9 • 8:00 PM EDT • Politics • eastasiaforum.org
Pierre LeBrun Floats Interesting Name for Red Wings GM job

Pierre LeBrun is surprised the Red Wings haven't interviewed former Detroit executive Ryan Martin during their ongoing GM search.

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Sep 9 • 6:22 PM EDT • Sports • sports.yahoo.com
Three All-New 'Audio Intelligence' Features Arrive With Apple Watch Series 12 and Ultra 4

Apple today announced "Audio Intelligence," a new suite of Apple Intelligence-powered features for the Apple Watch Series 12 and Apple Watch Ultra 4 that use the built-in microphone to help users catch missed moments in conversation and stay aware of important sounds.

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Sep 9 • 5:23 PM EDT • Technology • macrumors.com
Tyler reduces NET Health funding to $50K, citing agency’s reserves

The Tyler City Council approved a $287 million budget for the upcoming fiscal year in a 4-2 vote, cementing a 75% funding cut to the region’s local public health department.

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Sep 9 • 5:12 PM EDT • Health • kltv.com
Poll: Do Michigan voters support stricter political campaign finance rules?

Michigan voters were asked in a recent poll how they felt about the upcoming November general election. One question asked if Michigan voters supported prohibiting regulated utilities and government contractors from contributing to politicians, expanding campaign-finance disclosure rules and requiring disclosure for internet political ads.

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Sep 9 • 5:00 PM EDT • Politics • clickondetroit.com
Optum Health's partnership playbook

Optum Health's deal with TPG for its WellMed Florida clinics offers a potential playbook for its other provider markets like Texas.

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Sep 9 • 4:38 PM EDT • Health • axios.com
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Celebration of Healthy Aging for seniors held in Branford

BRANFORD, Conn. (WTNH) — Pushing back against the stigma of getting older, the Shoreline Eldercare Alliance Group hosted a Celebration of Healthy Aging in Branford on Wednesday. The group brings to…

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Sep 9 • 4:24 PM EDT • Health • wtnh.com
‘It Is a Great Time to Double Down on Behavioral Health’: How Payer Trends Are Driving Investment

This is an exclusive BHB+ story Evolving payer pressure is reworking the paradigm for provider organizations seeking to engage in M&A

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Sep 9 • 4:20 PM EDT • Health • bhbusiness.com
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Jacksonville mother files lawsuit over court-ordered C-section, alleges UF Health falsely reported she was suicidal

Cherise Doyley, the Jacksonville mother who was in active labor when a judge appeared on a tablet in her hospital room to consider whether doctors could perform a C-section against her wishes, has officially filed a federal lawsuit against UF Health and several individuals involved in the 2024 case.

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Sep 9 • 3:56 PM EDT • Health • news4jax.com
Tyler groups host fourth annual mental health workshop for Hispanic community

Sense of Self Counseling and Monarca partnered for their fourth annual workshop in Tyler to address mental health awareness and break cultural stigmas within the Hispanic community.

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Sep 9 • 3:16 PM EDT • Health • kltv.com
Maricopa entertainment center gets a name — MADCAPS

MADCAPS unveils name and first renderings of new entertainment and dining destination at Copper Sky Regional Park.

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Sep 9 • 2:50 PM EDT • Entertainment • azbigmedia.com
Apple Unveils the iPhone Duo, a Foldable Phone That Costs $1,999

At the company’s annual September product event, Apple also demonstrated its work on artificial intelligence and other new devices.

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Sep 9 • 2:47 PM EDT • Technology • nytimes.com
UMD researchers explain the science behind why leaves change color

Scientists say tracking pigment levels can show how trees respond to weather patterns

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Sep 9 • 1:50 PM EDT • Science • northernnewsnow.com
Apple Announces Apple Watch Series 12 With S11 Chip, Upgraded Health Sensors and Ceramic Models

Apple today announced the Apple Watch Ultra 4, featuring a new S11 chip, a redesigned health sensing system, and a larger battery that Apple says delivers two days of battery life. With improved power efficiency, Ultra 4 offers up to 18 hours of workout tracking with full GPS and heart rate monitoring, or 45 hours in its maximum extended workout mode. It comes in Black and Natural titanium, alongside new band colors and a new titanium Hermès band.

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Sep 9 • 1:42 PM EDT • Health • macrumors.com
Healthy Living with USA Health: Enlarged Prostate Treatment Options

In this Healthy Living, we talk with Troy M. Sofinowski, M.D., an Endourologist at USA Health.

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Sep 9 • 1:25 PM EDT • Health • fox10tv.com
Detroit's Dylan Larkin 'wants to be' in Minnesota, insider says

With the season less than a month away, Dylan Larkin may still be focused on his exit from Detroit, with Minnesota as his preferred landing spot.

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Sep 9 • 1:11 PM EDT • Sports • sports.yahoo.com
Can true horror really make it on Broadway? A stage version of 'Paranormal Activity' hopes so

Movie producer Jason Blum, known for revolutionizing horror films, praises a stage adaptation of his “Paranormal Activity” franchise.

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Sep 9 • 10:11 AM EDT • Entertainment • wsls.com
Small Business Spotlight: Guitar shop aims to strike a chord

WHAT MADE YOU WANT TO OPEN STRING THEORY GUITARS INC.? ALLISON & LEE WILLIAMS: “We are lifelong musicians with a passion for playing. We love Wilmington and the live music scene here, and we wanted a way to be a part of the music community without having to start work at 9 p.m. We also want to be a destination for residents and musicians performing in and around the downtown area.” WHAT DOES YOUR BUSINESS PROVIDE, AND HOW DO YOU THINK IT HELPS CUSTOMERS? We love Wilmington and the live music scene here, and we wanted a way to be a part of the music community without having to start work at 9 p.m. We also want to be a destination for residents and musicians performing in and around the downtown areaTHE WILLIAMSES: “We’re a true basics-to-boutique destination. If you’re someone who’s just starting out, we can set you up with high-quality, brand-new equipment at a great entry-level price point. When you’re ready for your dream guitar, we can help you design and create a fully custom electric or acoustic guitar to your specifications. We have a broad selection of both guitars and amplifiers for players of every level. We also have a community board in the store to connect bands, students, instructors, repair technicians, and anyone providing a service to the local music community.” WHAT PAST EXPERIENCE DO YOU HAVE THAT LED YOU TO CREATE STRING THEORY GUITARS? THE WILLIAMSES: “Lee has played guitar for almost 40 years, from middle school band to gigging rock bands. Allison has a background in orchestra and musical theater, as well as retail management. We worked together as a husband-and-wife team in manufacturing for many years prior to moving to Wilmington. Having shopped in countless music stores over the years, we set up our shop with the goal of being welcoming and inviting. Our philosophy is ‘if it’s on display, it’s for play.’ No instrument or amplifier is out of reach in our store.” WHAT GOALS DO YOU HAVE FOR GROWTH? THE WILLIAMSES: “We would love to grow the bluegrass and folk instrument segment of our business. We carry banjos, mandolins, resonator guitars, ukuleles and related accessories. We’ve seen and heard plenty of talented bluegrass and folk musicians around Wilmington, and we look forward to expanding our selections to support this growing segment of the local music scene.” WHAT CHALLENGES ARE YOU FACING RIGHT NOW IN YOUR BUSINESS? THE WILLIAMSES: “Getting the word out about our brand and some of the unique brands we represent is a challenge for any new business. Online exposure through the Cargo District, Wilmington Downtown Inc. … and our online following is steadily growing. Our other challenge is the logistics of our streets. Our neighborhood is amazing, and you could spend the entire day walking around the Cargo District. As the District continues to grow, we’re seeing more pedestrian traffic, particularly in crossing 16th and 17th streets. We’ve seen some improvements in traffic calming, but the sooner we can improve safety with crosswalks and pedestrian signals, the more welcoming our neighborhood will be.”

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Sep 9 • 9:00 AM EDT • Business • wilmingtonbiz.com
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

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Sep 9 • 9:00 AM EDT • Science • ourpublicservice.org
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

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Sep 9 • 9:00 AM EDT • Health • ourpublicservice.org
2une In Previews: LASM's 41st annual gala brings live entertainment, open bars, new art to Baton Rouge

2une In Previews: LASM's 41st annual gala brings live entertainment, open bars, new art to Baton Rouge

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Sep 9 • 8:00 AM EDT • Entertainment • wbrz.com
Lease dispute between Wegmans, Cary landlord heats up

A federal judge ordered Wegmans to pay $625,000 into court while the grocer battles its Cary landlord over an unbuilt store at Fenton.

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Sep 9 • 7:18 AM EDT • Business • bizjournals.com
San Antonio’s two largest business chambers explore formal partnership

Two of the largest business advocacy organizations in the San Antonio region are exploring a formal partnership.

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Sep 9 • 7:16 AM EDT • Business • ksat.com
Insurer markups only a small part of premium increases

Just cracking down on insurer overhead won't meaningfully bring down premiums.

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Sep 9 • 5:40 AM EDT • Health • axios.com
High-Signal Publisher
Mistrust of US government information is rising across major issues, new poll shows

A new AP-NORC/USA Facts poll finds that Americans are more skeptical of government information than they were a few years ago, with majorities now saying they have little or no trust in federal government information about elections, foreign affairs or the environment.

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Sep 9 • 5:05 AM EDT • Politics • ksat.com
Healthwatch: Should kids have mental health days?

Every school year, children eventually need to take a sick day – but what about a mental health day?

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Sep 9 • 3:24 AM EDT • Health • wsls.com
Can Innovative Fabric Science Solve the Workplace Safety Crisis? "All Access hosted by Andy Garcia" Explores Breakthroughs with Portwest

/PRNewswire/ -- Filmed on August 25, 2026, a new segment of "All Access hosted by Andy Garcia" highlights how modern material science is tackling...

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Sep 9 • 3:00 AM EDT • Science • prnewswire.com
The Business of Building a Medical Practice

In this episode of Entrepreneurial Shades of Gray, Dani sits down with Dr. William Boyd, who has spent more than 30 years building and running his own practices.

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Sep 9 • 1:00 AM EDT • Business • fox10tv.com
COVID-19 cases on the rise across all age groups, local healthcare expert says

Dr. Jason Bowling, the chief epidemiologist at University Health, said there is an increase in COVID-19 cases across all age groups.

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Sep 8 • 9:46 PM EDT • Health • ksat.com
Bernalillo County DA highlights need for accountability and reform in juvenile crime and behavioral health

Bernalillo County District Attorney Sam Bregman addressed crime, juvenile reform and behavioral health during a speech in Albuquerque, emphasizing the importance of accountability and treatment working together.

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Sep 8 • 8:10 PM EDT • Health • koat.com
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Where Michigan voters stand with single-payer health insurance, according to poll

Michigan voters were asked in a recent poll how they felt about the upcoming November general election. Some questions focused on Michigan voters’ opinions on the American health care system.

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Sep 8 • 7:00 PM EDT • Health • clickondetroit.com
The science of sleep trackers on smart watches

In this segment, scientists are issuing a caution about sleep trackers featured on devices like Apple Watch.

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Sep 8 • 6:07 PM EDT • Science • wbay.com
Samsung Health Recognized for Connected Care Innovation With Medicare App Library Inclusion and Recognition of Excellence for Its Support of “Kill the Clipboard”

Samsung Health has been added to the Medicare App Library. The inclusion follows Samsung’s recognition from CMS for its "Kill the Clipboard" initiative, advancing its vision for connected care.

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Sep 8 • 6:00 PM EDT • Health • samsungmobilepress.com
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Smithfield Foods expects to swing to third-quarter operating loss in fresh pork business

Smithfield Foods said on Tuesday its fresh pork segment is expected to swing to an adjusted operating loss in the third ​quarter, due to persistent pressure from lower hog prices and ‌a shrinking industry market spread amid cautious spending.

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Sep 8 • 5:49 PM EDT • Business • reuters.com
Report: Red Wings Still Without GM as Camp Nears

Detroit still has no general manager, and Shawn Horcoff took the NHL's GM call. #RedWings

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Sep 8 • 4:37 PM EDT • Sports • sports.yahoo.com
Cubs Hit A Home Run With Alex Bregman
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Sep 8 • 4:30 PM EDT • Sports • sports.yahoo.com
'We're resilient': Maine businesses brace for new round of Canadian tariffs

Canada is officially striking back in the trade war with the United States.

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Sep 8 • 4:19 PM EDT • Business • wgme.com
Business Aviation Insight. Reassessing Large-Cabin Value After the Falcon 900LX’s Final Delivery Year

Challenger 650 – Photo Credit: Bombardier The Falcon 900LX and Challenger 650 sit at opposite ends of a large-cabin segment that, on 2026 data, now spans nearly $19 million in …

Fire that destroyed Richmond business ruled welding accident

Welding is to blame for a fire that destroyed a business in Richmond Monday.

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Sep 8 • 1:53 PM EDT • Business • wgme.com
Ram Getz & Michael Mortensen Launch i80 Entertainment (EXCLUSIVE)

Ram Getz and Michael Mortensen, partners at GM Management, have launched i80 Entertainment, a new independent production company.

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Sep 8 • 1:50 PM EDT • Entertainment • deadline.com
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Aaron Rodgers praises Karl Ravech for ‘phenomenal’ ESPN tenure

Aaron Rodgers loves to hate on ESPN, and the Worldwide Leader may have given him a little more ammunition by parting ways with Karl Ravech. Rodgers was recently interviewed by Adam Schein on his SiriusXM Mad Dog Sports Radio show. At the end of the segment, Schein boldly gave Rodgers the open forum to share…

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Sep 8 • 12:30 PM EDT • Sports • sports.yahoo.com
Live Results: Rhode Island midterm primaries

Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.

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Sep 8 • 11:55 AM EDT • Politics • pbs.org
David Kerr named GM of Mississippi Mud Monsters

PEARL, Miss. (WJTV) – The Mississippi Mud Monsters announced that David Kerr has been named General Manager of the organization after serving as Assistant General Manager since the club’s launch. Kerr was formally introduced in his new role during a news conference at Trustmark Park on September 8, 2026. “David has been right in the […]

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Sep 8 • 11:34 AM EDT • Sports • sports.yahoo.com
Simon Edvinsson Makes Decision With Red Wings Contract Unresolved

Simon Edvinsson plans to attend Red Wings training camp without a new contract as Detroit's ongoing GM search continues to delay negotiations.

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Sep 8 • 11:04 AM EDT • Sports • sports.yahoo.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
The Latest: Canada strikes back with tariffs on about $20 billion worth of US goods

Canada struck back at U.S. President Donald Trump on Tuesday with tariffs on about $20 billion worth of U.S. goods, in response to his latest round of tariffs on Canada.

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Sep 8 • 10:13 AM EDT • Politics • ksat.com
The final season of ‘Yellowjackets’ is not holding back: ‘We get a little crazy’ (exclusive)

They’re being rescued! An exclusive first look at the final season of ‘Yellowjackets’ digs into the aftermath of the wilderness (and Wilderness) as co-creator warns, ‘Buckle up.’

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Sep 8 • 10:00 AM EDT • Entertainment • ew.com
Report: Wild willing to pay Quinn Hughes $20.5M annually

Will they only pay him the record-setting amount if he signs for eight years? Or are they willing to make him the highest-paid player on a shorter-term contract?

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Sep 8 • 9:44 AM EDT • Sports • sports.yahoo.com
Swan Island businesses brace for I-5 closure

Freight, shipyard and service businesses have little room to dodge the traffic.

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Sep 8 • 9:19 AM EDT • Business • axios.com
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Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk

A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.

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Sep 8 • 9:05 AM EDT • Entertainment • wsls.com
WSU receives $2.5 million to expand street medicine training

Doctors in WSU’s internal medicine residency program will learn to care for people experiencing homelessness by meeting them where they live in Everett and Spokane.

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Sep 8 • 9:00 AM EDT • Health • news.wsu.edu
Ancient Roman fresco and mosaic featuring maritime city unveiled at newly restored Baths of Trajan

Authorities in Rome have unveiled what is believed to be the largest fresco and mosaic complex of ancient Rome.

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Sep 8 • 8:15 AM EDT • Entertainment • wsls.com
Video Global report shows where US kids rank in reading, math and science

ABC News' Elizabeth Schulze has the results of a new report released this morning showing where U.S. students rank compared with students around the world.

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Sep 8 • 7:36 AM EDT • Science • abcnews.com
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months

This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.

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Sep 8 • 7:21 AM EDT • Health • fox10tv.com
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months

This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.

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Sep 8 • 7:21 AM EDT • Health • wdbj7.com
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months

This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.

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Sep 8 • 7:21 AM EDT • Health • live5news.com
Alabama Department of Mental Health highlights life-saving resources for Prevention and Recovery Months

This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.

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Sep 8 • 7:13 AM EDT • Health • wsfa.com
Top Mathematician Announces New Institute for A.I. Safety

Jacob Tsimerman, a recent recipient of the Fields Medal, believes that higher mathematics can help curb the dangers of runaway artificial intelligence.

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Sep 8 • 7:00 AM EDT • Technology • nytimes.com
Trump threatens Canadian jetmaker Bombardier, which has an extensive US footprint

U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States.

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Sep 8 • 6:52 AM EDT • Business • clickorlando.com
Trump threatens Canadian jetmaker Bombardier, which has an extensive US footprint

U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States.

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Sep 8 • 6:52 AM EDT • Business • ksat.com
🚨 Best women's and men's coach: Ballon d'Or nominees

Who will succeed Sarina Wiegman and Luis Enrique? This year, too, the Ballon d'Or will once again award the honors for Best Men’s Coach and Best Women’s Coach. The nominees have just been announce...

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Sep 8 • 6:32 AM EDT • Sports • sports.yahoo.com
How Christians can fight back against Christian nationalism

A new book argues the future of democracy depends on a segment of American Christians. What should they do?

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Sep 8 • 6:00 AM EDT • Politics • vox.com
How 2026 candidates are targeting health care "corruption"

They're accusing opponents of being in the pockets of drugmakers or health insurers.

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Sep 8 • 5:30 AM EDT • Health • axios.com
High-Signal Publisher
‘Pawn Stars’ star Rick Harrison gets major health update after emergency heart surgery

It comes just days after he was rushed into surgery.

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Sep 8 • 5:05 AM EDT • Entertainment • pennlive.com
‘Pawn Stars’ star Rick Harrison gets major health update after emergency heart surgery

It comes just days after he was rushed into surgery.

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Sep 8 • 5:05 AM EDT • Health • pennlive.com