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The Oscars are leaving Hollywood
In 2029, the Oscars will move from the Dolby Theater in the heart of Hollywood to the Peacock Theater at L.A. Live, a sprawling tourist hub in Downtown Los Angeles,
This breakout teen performer is hitting Baton Rouge with a new tour. See who, how to get tickets.
And he has 1.2 billion-plus global streams
Movie Review: 'Two Prosecutors' is a perfect nightmare of state corruption
Sergei Loznitsa’s “Two Prosecutors” is a nightmare of government corruption so perfectly composed that, by the time it reaches its chilling conclusion, you feel nearly as entrapped as its young
AAN Art from the Schools at Johnson Gallery
The Artists Association of Nantucket kicked off its annual Art from the Schools exhibition of work by island students in grades six-12 with an opening reception and the presentation of
Danish twins, Nicolai and Rasmus Højgaard, commit to the 2026 Zurich Classic
Nicolai and Rasmus Højgaard have committed to play in the upcoming Zurich Classic, tournament officials announced Thursday.
OU quarterback John Mateer confident in throwing mechanics in spring practice
Redshirt senior quarterback John Mateer expressed confidence in his throwing ability to start spring practice.
Data show people racing to chatbots for health advice
In this edition of STAT Health Tech: More people use chatbots for health advice, a health AI startup raises $125 million, and all about deepfaked medical images.
What to stream in April 2026: ‘The Testaments,’ ‘Big Mistakes’
Here's what's coming to Netflix, Hulu, Disney+, HBO Max, Prime Video, Peacock, Paramount+ and other streaming services in April.
Letter | Abused Ridglan dogs are not good for science
Dear Editor: I am a professor and data scientist with over 25 years of experience in biomedical data collection and analysis, including studies that employ animal models for research. The
Join award-winning filmmaker for conversation on conservation
A free conservation event featuring a six-time Emmy award-winning filmmaker will take place Saturday morning at First Congregational Church in La Crosse.
Photos: Pro Football Cares Sports Emergency Response Training at Raiders HQ
A Pro Football Cares Sports Emergency Response Training was held at Raiders HQ where athletic trainers and coaches were able to participate in a series of simulations on football equipment removal, cardiac arrest and exertional heat stroke.
'Big Bang' trivia, Spring Garden Fest, YMCA 5K and more events in Baton Rouge this week
Looking for something to do?
Summer of the Arts announces 2026 Iowa Arts Festival Main Stage lineup
Summer of the Arts has announced the return of the Iowa Arts Festival from June 5–7 in downtown Iowa City. This year’s main stage lineup brings a dynamic weekend of live music, featuring an exciting mix of local favorites and nationally recognized performers.
The Grant Wood Studio and Armstrong Visitor Center to reopen in April
Explore where artist Grant Wood painted some of his most famous artwork, including “American Gothic,” at his former studio. Reopening April 11, The Grant Wood Studio and Armstrong Visitor Center provides an enriching, artistic experience to visitors for free.
Intel CEO Lip-Bu Tan: Startup investment is critical for business
Developments in AI, quantum computing and robotics are moving so fast that corporations must stay close to startups to avoid falling behind.
As political winds shift, this Louisiana renewable energy venture shoots for the stars
"We've spent years figuring out how to make wind blades lighter, stronger and cheaper — and we're set up at a facility that will allow us to expand quickly into production and shipping at scale. Now we're ready to apply those strengths to booming sectors of the economy."
Hurd joins Colorado Dems in urging authorization of Small Business Development Center funding
A group of six members of Colorado’s delegation in U.S. Congress wrote a joint letter to the Small Business Administration (SBA) over its failure to provide prompt spend authority for
The Riverside-St. Martin's baseball winner was led by a senior pitcher's complete game
Riverside senior right-handed pitcher Jayce Ruiz repeated his prior success against St. Martin’s by throwing a complete game in the second game of a district series.
From Shells to Science
If you were a fifth grade student at Manatee Elementary School, coming to school on a Thursday after Spring Break might not seem very exciting at first.
The Herald's weekly entertainment picks
Looking to be entertained from Thursday, March 26, through Wednesday, April 1? Check out the Skagit Valley Herald’s weekly recommendations.
Dartmouth hockey team brings championship experience to NCAA Worcester regional
The Dartmouth College men’s hockey team has already won a championship. Now the Big Green are looking for another one, and it starts Thursday in the NCAA Division I tournament’s
Democratic lawmaker asks judge to take Trump's name off Kennedy Center
A Democratic lawmaker is asking a federal judge to force the Kennedy Center to block and reverse efforts to attach President Donald Trump’s name to the historic performing arts venue.
Lana Condor talks ‘Pretty Lethal,’ Pacific Northwest-set ‘Whodunnit’
Lana Condor gets to utilize her dance skills in the action thriller "Pretty Lethal," which is now streaming on Prime Video.
Taproot Theatre’s ‘Ain’t Misbehavin’’ is a Fats Waller celebration
The high-energy musical revue celebrates the work of jazz piano legend Fats Waller.
Author Stephen Graham Jones discusses his writing process
Jones, who has written more than 30 books, will visit Seattle on March 30 for an event with Seattle Arts & Lectures.
How to watch Mariners games: TV, streaming and channel info
Finally, just before opening day, an answer for fans looking to watch Mariners games on TV. Here's how to watch the M's through cable and satellite provider.
The Guardian view on a significant week for European politics: progressives have some reasons to be cheerful
Editorial: Events in Denmark and Italy show geopolitical instability is creating opportunities for a centre-left response to the far right
Meta and YouTube found liable in social media addiction trial
A California jury has found Meta and YouTube liable on all counts in a landmark case that accused the tech giants of intentionally addicting a young woman and injuring her
Jaguars President Mark Lamping & Mayor Donna Deegan Unveil Jaguars' New Business Headquarters
Jaguars President Mark Lamping and Jacksonville Mayor Donna Deegan speak to the media to provide a detailed overview of the Jaguars' new business headquarters. They discuss the vast improvements to the office space as well as the other businesses that wil
Mauricio Culebro named President of Soccer, AMB Sports and Entertainment
Former President of Tigres UANL takes the helm of MLS Atlanta United and launch of NWSL Atlanta in 2028
Mauricio Culebro named President of Soccer, AMB Sports and Entertainment
Former President of Tigres UANL takes the helm of MLS Atlanta United and launch of NWSL Atlanta in 2028
Jaguars President Mark Lamping on Impact of New Business Headquarters in Downtown Jacksonville
Jaguars President Mark Lamping meets with the media following the grand opening of One Tower Court: The Jaguars' new business headquarters.
Jaguars Cut Ribbon on New Business Headquarters at One Tower Court
Downtown’s Newest Class-A Office Building Also Celebrates Opening for Downtown YMCA Branch, Announces Timucuan Asset Management and Foley & Lardner LLP as Tenants
Sub Pop has signed its latest Seattle band, Telehealth
The Seattle synth-punks became fast favorites on the local scene with their 2023 debut.
Player availability report, presented by Orlando Health Orlando Health Jewett Orthopedic Institute: Orlando Pride at Chicago Stars
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match at Chicago Stars
Birthday boy is Bach!
Blue Hill Bach will celebrate Early Music Month with an “intimate chamber baroque” concert honoring Johann Sebastian Bach’s 341st birthday at St. Francis by the Sea Episcopal Church on Friday,
Inter Miami CF Announces Heron Sports & Entertainment as Club Continues Unprecedented Growth
Heron S&E to serve as promoter of major entertainment events both locally at their new home at Miami Freedom Park, Inter Miami CF Stadium in Fort Lauderdale, the Florida Blue Training Center, and globally Continuing to push the boundaries in the global entertainment landscape, Inter Miami CF is excited to
Inter Miami CF Announces Heron Sports & Entertainment as Club Continues Unprecedented Growth
Heron S&E to serve as promoter of major entertainment events both locally at their new home at Miami Freedom Park, Inter Miami CF Stadium in Fort Lauderdale, the Florida Blue Training Center, and globally Continuing to push the boundaries in the global entertainment landscape, Inter Miami CF is excited to
Compilation of Events Supported by Heron Sports & Entertainment
With the opening of Nu Stadium in Miami, Heron Sports & Entertainment, the dedicated platform focused on arranging, promoting, and producing major events in South Florida and Globally enters a new era. Since opening its doors in 2020, the Club’s state-of-the-art facilities have staged hundreds of events including Major International
Compilation of Events Supported by Heron Sports & Entertainment
With the opening of Nu Stadium in Miami, Heron Sports & Entertainment, the dedicated platform focused on arranging, promoting, and producing major events in South Florida and Globally enters a new era. Since opening its doors in 2020, the Club’s state-of-the-art facilities have staged hundreds of events including Major International
Could Mizzou football's 2015 boycott be replicated today in college sports?
With the landscape of college sports shifting dramatically since 2015, it might make the possibility of a boycott difficult.
Movies and TV shows casting across the US
Backstage compiled a list of movies and TV shows casting across the US.
Movies and TV shows casting across the US
Backstage compiled a list of movies and TV shows casting across the US.
Movies and TV shows casting across the US
Backstage compiled a list of movies and TV shows casting across the US.
Double plays help Jesuit-Brother Martin winner create tie atop Catholic League standings
The teams will play a second game Thursday at Kirsch-Rooney Stadium.
5 events in Lancaster County this weekend, from \'Heated Rivalry\' dance party to magic swap meet
Before you make your weekend plans, make sure these events are on your radar.
‘Daredevil: Born Again’ Season 2 review: Balancing the scales of justice
Season 2, which premieres Tuesday on Disney+, is a greatly entertaining blend of crunchy action and compelling narrative, writes our reviewer.
Top entertainment headlines for March 24
Gwen Baumgardner has your Eye on Entertainment report.
Confluence Health physician assistant recognized with statewide award
WENATCHEE — A Confluence Health clinician was named the Rural Physician Assistant of the Year earlier this month by the Washington Academy of Physician Assistants.
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Judy Davis, left, Elijah Tamati, Miriam Margolyes and Jacki Weaver star in director Nat Boltt's "Holy Days."
7 new children’s and young adult books by local authors
The Northwest is home to a vibrant community of children’s and young adult authors. Celebrate early reading with these recommendations.
Crowds fill 14th Annual St. Joseph’s Day Festival
The 14th Annual St. Joseph’s Day Festival hosted by the Ocean City (Md.) Sons & Daughters of Italy Lodge is in the books with another success, as demonstrated by the
Jewelry Extravaganza to raise funds for Millsboro library
On April 16-18, the Friends of the Millsboro Public Library will be presenting their annual Jewelry Extravaganza fundraiser, the proceeds from which will be used to support the children’s summer
Bethany to celebrate milestone year with Seaside Concert Series
As the United States commemorates its 250th anniversary, Bethany Beach will celebrate a milestone of its own — its 125th birthday.
Charlie’s Beat: A healthy life, well lived
Today’s story comes from a personal perspective, about a person who’s been in my life for close to 50 years. Bryant Stamford was the Fitness & Nutrition columnist for the
Tacoma Arts Live, longtime WA arts institution, files for receivership
Tacoma Arts Live, a longtime performing arts organization, has filed for receivership. The court process is similar to bankruptcy. Here's what we know.
‘Corpus Christi’ returns to the Bartell, years after protests
StageQ, Madison’s LGBTQ community theater, stages Terrence McNally’s controversial retelling of Jesus’ life and crucifixion through Easter weekend.
Josh Shapiro endorses James Malone in key Lancaster County Senate race
Gov. Josh Shapiro has officially endorsed James Malone’s bid for reelection in the Lancaster County state Senate district that both parties say could determine party control next year.
UGA student turns mahjong passion into growing business: Marejong
University of Georgia student Mary Dalton Dowdy started her own business, Marejong, teaching mahjong lessons in Athens, Jefferson, Watkinsville and Wrens, Georgia. She found a unique market, becoming one of
Christine Ebersole, Cheyenne Jackson and a Sunday night in New Orleans I'll never forget
The invitation said "Un Salon Moderne à la Nouvelle-Orléans." That was about all anyone knew. Jan Risher was in New Orleans Sunday night for an event that nobody saw coming — and what it left her thinking about.
City hosts workshop on business license renewals
The City of Paducah’s Finance Department hosted an informational workshop on business license renewals on Monday to help local businesses understand the process before the April 15 deadline.
Entertainment district ordinance repeal not on city council agenda
Entertainment district ordinance repeal not on city council agenda
Entertainment district ordinance repeal not on council agendas despite Ward 7 councilmember claims
Norman City Council will not see an ordinance repeal related to the Rock Creek Entertainment District during Tuesday’s city council meeting, despite a statement from a council member that it
Photos: LSU players impress NFL scouts on Pro Day 2026
NFL scouts gathered at the LSU football practice facility to see 17 LSU players that have declared for the 2026 draft on Monday, March 23, 2026. Players like Garrett Nussmeier,
Jacobs Entertainment gets permits for sports fields, now under construction
2 News Nevada has gotten a look at new youth sports fields that are under construction in downtown Reno.
Dual-threat Dixon makes an impact beyond his own sport
Few athletes embody their sport and community like senior track and field athlete Ashriel Dixon.
Manor Township Democratic committee person kicked off May 19 primary ballot
Kirk Barrett, a candidate for a Manor Township seat on the Lancaster County Democratic Committee, has successfully kicked the incumbent’s name off the ballot for the upcoming May 19 primary.
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Cheyenne Jackson performs "I'm Feeling Good" on Sunday evening, March 22, 2026, at "Un Salon Moderne à la Nouvelle-Orléans" at the gallery and private residence of Martine Chaisson in New
How entertainment production hubs are creating new housing hotspots
NewHomeSource reports entertainment production hubs are driving housing demand by boosting local economies, attracting home buyers with modern amenities and community design.
Trump sued by historic preservation groups to block Kennedy Center changes
A coalition of preservation groups is suing to stop major physical changes at the Kennedy Center under President Donald Trump’s renovation plans. On Monday, the groups filed a lawsuit against
Peregrine Road performs at the Jesup
BAR HARBOR — On Thursday, April 9, at 5:30 p.m., the Jesup will host a free Music and Conversation program with Peregrine Road (Rachel Bell and Karen Axelrod). Peregrine Road
2nd Car Show Scheduled at Sangertown Square
Racing fans and families can check out high-performance cars and meet local drivers at the Mall Car Show at Sangertown Square.
David Gallo opens up about why AI data centers, private equity are good for his company
After Katrina, David Gallo led his family's company, Gallo Mechanical, through a geographic expansion that helped grow the company to nearly $500 million in revenues and more than 700 employees. Last year, he led the 80-year-old business through a sale to a private equity firm. In this week's Talking Business, he explains why it was a good thing
Best selling author Marie Benedict to talk at the United Theatre
WESTERLY — Marie Benedict, the Pittsburgh-based author known for using real — mostly forgotten — women as inspiration for her bestselling works of historical fiction, was on the phone Tuesday
Pfeiffer, Pulley Join The Core Entertainment Leadership Team.
The Core Entertainment has added Sarah Pfeiffer as Head of Marketing and Gabriella Pulley as Chief of Staff. Both will report to Co-Founders and Co-CEOs Simon Tikhman and Chief Zaruk
Letters: Newspapers hold a position in our democracy, unlike any other business
I read with interest Duke Truby's viewpoint about a newspaper print medium being a "business" in the strictest sense. As such, that business should cater to its customers and clients.
Norman City Council to consider ordinance repeal related to Rock Creek Entertainment District
Norman City Council will consider repealing an ordinance related to the Rock Creek Entertainment District during its Tuesday meeting, according to a council member’s social media post.
Students Learn the Science of Tree Felling at Treehaven
Click here to view this video from wjfw.com.
UTA College of Business to connect students, professionals with networking, elevator pitch event
Students, business professionals and recruiters will mingle from 6 to 8 p.m. Monday at the UTA Center for Entrepreneurship and Technology Development.
City of Paducah Finance Department to host informational workshop on Business License Renewals
In case you missed it, the City of Paducah Finance Department will host an informational workshop on Business License Renewals for local business owners at the McCracken County Library tomorrow,
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Buffalo Museum of Science celebrates 50% completion of upcoming Science Stadium Exhibit
The Buffalo Museum of Science marked a major milestone in its $3 million Science Stadium exhibit, announcing on March 20 the project is now 50% complete ahead of its planned
Fitchburg Public Library hosts Wisconsin Film Festival preview
FITCHBURG, Wis. — The 28th Wisconsin Film Festival is coming up in just a few short weeks, and a local library is helping get the word out.
70 judges peruse hundreds of science fair projects at Interior science fair
Fourth-grader Lexi Snow wondered why she always blushes.
\'Saturday Night Live UK\' aims to take a comedy hit across the pond. The first verdicts are in
A British version of “Saturday Night Live” has debuted to largely positive reviews. The first episode of “SNL UK” was hosted by Tina Fey, a veteran of the American show,
Nashormeh N. R. Lindo wears colorful dress to Oscars after-party
Lindo attended the after-party with her husband and supporting actor nominee for "Sinners," Delroy Lindo.
Margaret Cho on comedy, politics, and life in Hollywood
Comedian and actress Margaret Cho discusses her penchant for tackling political themes in her performances, evident in her upcoming tour, "Choligarchy,” coming to the Englert Theatre Friday, March 27.
Lancaster County public sales: March 22, 2026
Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and
FYI BR: Here are the upcoming Holi and Easter festivities in Baton Rouge
Plan for pictures with the Easter Bunny, festivities at the LSU Rural Life Museum and more.
New law firm formed; new executive director at chamber; hospital picks new chief of staff
Take a look at some of the recent promotions and new hires announced at south Louisiana businesses.
Politics: Iowa Senate majority leader outlines plans for coming weeks
Second funnel week concluded in the Iowa Legislature, meaning that lawmakers’ focus can return to funding, appropriations and other types of specific bills that don’t respond to the Legislature’s self-imposed
Recap: Sporting KC suffers 4-1 loss to Colorado
Sporting Kansas City suffered a 4-1 loss to the Colorado Rapids on Saturday at Sporting Park. Shapi Suleymanov scored the lone goal for SKC in the defeat as the visitors prevailed behind a brace from Paxten Aaronson to go along with a goal from fellow Designated Player Rafael Navarro and
OU women's gymnastics senior Faith Torrez scores perfect 10, while Sooners lose in SEC championship
No. 1 OU women’s gymnastics (18-1-1) finished second in the Southeastern Conference Championship against No. 3 Florida (15-2-0), No. 2 LSU (12-5-1) and No. 4 Alabama (9-8-0) Saturday, with the
Photos: Costly error as LSU drops series to Oklahoma
An error in the eighth inning by LSU helped lead to the game winning run for Oklahoma in the final game of the series on Saturday, March 21, 2026 at
Utica University Science Fair Inspires Young Scientists
Young scientists from local middle and high schools gathered for the 47th annual Utica University Regional Science Fair.
COLUMN: Frager punches Nebraska men’s basketball’s ticket to Sweet 16
Yes, this is real. It isn’t a dream or a movie. The Huskers are moving on to the Sweet 16 in Houston next week.
Four takeaways from Nebraska men’s basketball’s NCAA Tournament win over Vanderbilt
OKLAHOMA CITY – Braden Frager. Learn the name.
Uber's Advertising Business May Be Bigger Than Investors Think
Uber is best known for moving people and delivering food. However, something small but potentially profitable is growing at the company.
47th annual Utica University science fair shows area students are smarter than ever
Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.
Outrageous antics and mistaken identities abound
How far would you go to protect your son, your lover and your secret about your brownies?