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Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS
A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.
Ramaswamy built his political career in NH. It's faltering in Ohio.
Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?
Board of Deputies of British Jews declares Greens to be racist party
The Jewish body's vote comes in response to the Green Party passing a "Zionism is racism" policy motion.
Trump on high gas prices: 'We're making a freaking fortune"
Americans, meanwhile, are paying record prices at the pump, according to AAA.
Olympiacos May Attempt to Sign Genoa Midfield Maestro This Winter
Olympiacos are poised to reignite their pursuit of Morten Frendrup, testing Genoa's resolve after a rejected summer bid for the consistent Danish engine room specialist.
Made in Tarrant: Family turns sports card hobby into baseball stadium business
Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.
The Times' top 25 high school football rankings
A look at the top 25 high school football teams in the Southland after Week 9.
Made in Tarrant: Family turns sports card hobby into baseball stadium business
Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.
Candidates differ on taxes, schools, health care
House hopefuls outline priorities ahead of election
Navigating D1 pressure: how student-athletes balance their mental health
Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...
Detectives seek information about business conducted with Piedmont Memorial Park Cemetery
Detectives are seeking information from anyone who has conducted business involving the cemetery since January 2019.
Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside
Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain
Three receptions for Germie Bernard
Steelers WR Germie Bernard catches three of his five targets in Week 7 win
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report
The New York Knicks look for their first win of the season.
College GameDay On-Site for Gophers vs Hoosiers
The Minnesota Gophers are coming off a big win over Iowa. And now College GameDay is going with the to Bloomington Saturday for the game @ Indiana.
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame
Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.
Chris Olave targeted 10 times in Week 7
New Orleans wide receiver Chris Olave went for six receptions for 56 yards on 10 targets in Week 7
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina
Penalties, brain blips and a hangover conspire to doom Volunteers.
Google's privacy policy now has a loophole for using your Gmail and Photos data in ads
The change sits in Google's updated privacy policy, which took effect on October 16 and was first spotted by Android Authority. The policy has long said, "We...
Schefter: Seahawks among teams ‘expected to consider’ Jonathan Taylor trade
The Seahawks are “pondering” adding Taylor in hopes of saving their run game.
Projections for Cleveland Guardians’ Arbitration Eligible Players
The Cleveland Guardians have several key players arbitration-eligible this offseason.
BCM hosting special Nov. 13 show for America 250
BRISTOL — In partnership with The Crooked Road: Virginia’s Heritage Music Trail, Mountain Empire Children’s Choral Academy, and Theatre Bristol, the Birthplace of Country Music Museum is bringing together an
Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode
Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.
Lakers at Jazz: What to watch in first road game
Walker Kessler needed only two games to show how much he could change the Los Angeles Lakers' frontcourt.
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record
'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.
Union County Best of the Best Business of the Year Magnolia Renovations Joshua Andrews, owner
What was your reaction when you learned your business had been named Business of the Year?
My husband and I moved abroad in our 50s, didn't want to waste time
Leslie Hodgin and her husband decided to stop waiting to move abroad, selling most of their belongings and relocating to the Netherlands.
Sunday Open Thread
There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
What Will It Take for Rockies to Make World Series?
It's been since 2007 for the Colorado Rockies to be a part of the World Series. Is there any hope for a return to the Fall Classic?
Clatsop County health inspections for September
Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]
New Trump housing order targets mortgage and title insurers
A White House plan to pull private mortgage insurance off loans sooner, and to let refinancing borrowers skip the lender's title policy, affects two insurance lines that say they already help keep costs down
Hunter's Moon 2026: All About October's Full Moon And What To Expect Tonight
The title "Hunter's Moon" dates back generations, originating in the Northern Hemisphere because it typically follows the harvest season.
Carrick ‘not expecting’ Man United crisis talks despite Bournemouth defeat
Michael Carrick said he is ‘not expecting’ imminent talks about his future despite Manchester United’s latest defeat.Carrick’s position as head coach looks under threat after Manchester United...
Senate rivals seek support from Alaska Native voters
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election
Steelers beat Saints to win first NFL game in Paris
The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.
Business People: Evereve names industry vet Sarah Clary to advise on creative
RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race
WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Clayface Takes First Place While Holmes Documentary Grows in Week Two
Clayface opened with $24.5M, while A24's three-hour Elizabeth Holmes documentary You Can See Everything grew 25% in its second weekend.
Aaron Rodgers throws for 212 yards in Week 7
Steelers QB Aaron Rodgers sees multiple TD streak snapped in Week 7 win
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex
West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.
Warren, Steelers stiff-arm Saints for 16-10 Paris win
Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”
Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.
Sunday Puzzle: BRB
NPR's Ayesha Rascoe plays the puzzle along with Weekend Edition Puzzlemaster Will Shortz and WUOT listener Jordan Bogdan of Oak Ridge, Tennessee.
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department
BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Kansas at Duke: Exhibition OGT
Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
Photographer and medical professionals connect science and art during panel discussion
In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...
Bloomington business continues to blossom
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MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
Week 7 inactives for Ravens
Baltimore declares five players inactive versus Cincinnati
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns
The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]
Apollo: AI has delivered 'zero financial payoff' to corporate America
Only tech companies are seeing growth from the AI boom, Apollo Global Management said.
In West Maui, Democrat-turned-Republican defends House seat against Lahaina Strong organizer, local business advocate
Incumbent Rep. Elle Cochran, Green Party candidate Pā’ele Kiakona and Democratic nominee Sne Patel are battling to represent West Maui at a pivotal time in the fire recovery.
How the conservative Supreme Court has rewritten the rules for the midterms
Voters will pick the winners of next month’s midterm elections, but it is the conservative Supreme Court that has set the rules.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago
"Music is not a matter of life and death, it’s something much more serious than that"
Americans have a grief problem we still call a mental health problem
OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.
Political cartoons for October 25
Sunday's political cartoons include increasing costs, the White House briefing room, and more
Blue Ivy takes the stage, Destiny’s Child reunites at Jay-Z’s L.A. concert
Blue Ivy Carter joined dad Jay-Z onstage for a piano accompaniment, while mom Beyoncé cheered her on with two very special guests.
Astros should stay away from these 2 free agent outfielders
Astros shouldn't be interested in these two outfielders.
Republican responds to AI video in Fort Bend County political battle
Fort Bend County has seen plenty of controversy at its highest levels.
RJW Logistics to open second Northwest Arkansas office
Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation
Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...
#ESMO26: Merck and Moderna's cancer vaccine data were 'a triumph of science.' And now, the work begins
Merck and Moderna’s intismeran cut melanoma recurrence risk 42% at ESMO; experts weigh other tumors, manufacturing and boosters.
Obama and Trump wage one last battle for even more urgent stakes
Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.
Chivu: “The boys gave everything right to the end”
Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
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How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
California Politics 360 full episode | Clash over voter rolls heads to court
On Tuesday, one week before the election, a federal judge will determine the next steps.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots
The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.
Google's next TV gadget may do much more than stream
A reported hardware overhaul could bring Gemini further into the living room.
Florida political leaders mourn after shooting at FAMU homecoming
Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream
Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.
Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Postpartum recovery window may play a critical role in maternal aging and long-term health
In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.