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UND again named among region’s best places to work
Prairie Business recognition reflects workplace culture created by UND faculty and staff.
Actor Says Theatre Fired Him from “Bright Star” Over His Adult Entertainment Past
An actor says he was fired from an upcoming production of Bright Star just before rehearsals began after the theatre learned about his past work in adult entertainment.
Buffalo Bills name 6 captains for 2026 NFL season
Who joins quarterback Josh Allen and linebacker Terrell Bernard as an official captain for the Buffalo Bills in 2026?
Dunlap highlights high home heating oil prices in Maine
Dunlap, who faces former Republican Gov. Paul LePage on the Nov. 3 ballot, said Maine continues to be the state where more people rely on home heating oil than any other.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Third kit to debut against Fluminense
The debut of Galo’s third kit, in orange, will take place in next Saturday’s match (12/9), at 4:00 p.m., against Fluminense, at Arena MRV. The match will be valid for the 27th round of the Brazili...
Government land-grab agenda hits key Senate race as Dem backs property takeovers echoing Mamdani
Maine Senate candidate Troy Jackson suggested the state should take over mobile home parks, echoing NYC Mayor Zohran Mamdani's housing agenda.
Russell Peters opens up about race, politics and why he still needs comedy
Russell Peters talks race, prejudice, politics, and why making people laugh still matters.
Iconic Spurs entertainment tradition returns
Spurs fans will notice an electrifying new addition to the game day experience at Frost Bank Center this season. After eight long years, the iconic all-female dance group — the Silver Dancers — will grace the sidelines once again. Spurs Sports and Entertainment originally dismantled the team in 2018 after their 26th season due to...
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Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
Women immigrant-owned businesses featured at massive market at HER Tel Aviv festival
“We really want to show the diversity and the connection and the love for Israel,” HER Tel Aviv founder and CEO Sivan Hadari said.
Missy Woods sentenced Tuesday
The former high-profile CBI analyst got a decade in prison on four counts A Jefferson County district court judge on Tuesday sentenced a disgraced former Colorado Bureau of Investigation DNA analyst to a decade in prison. Jefferson County District Judge Andrew Poland sentenced Yvonne “Missy” Woods to 10 years on the most serious felony charge, […]
MAC now says Big Ten replay officials erred in adding 1 second back for Michigan's Hail Mary, asks NCAA to recognize Western Michigan as the winner
How to watch the Seattle Seahawks opener against New England
The reigning champions take on the New England Patriots in a Super Bowl LX rematch to start the season, with a unique Wednesday game. Here's why.
Roundup: Using AI to better integrate virtual modalities into care delivery
Artificial intelligence enhancements in telehealth aim to bolster care continuity while virtual nursing extends bedside care. Also, Zocdoc integrates with Google Gemini to book appointments while Sword Health is set to acquire Headspace's parent company.
OECD: Heavy AI Use Linked to Lower Science Scores
New PISA data shows students who use AI daily score 28 points lower in science; OECD urges using AI to support, not replace, learning.
Astronaut Health, Lunar and Earth Photography Fill Crew’s Research Schedule
Exploring astronaut health and photographing the Moon and Earth topped the research schedule for the Expedition 75 crew aboard the International Space Station on Tuesday. The orbital residents also kept up life support maintenance following the departure of cargo spacecraft the day before.
More evidence that mass shootings are suicidal acts
New research finds national peaks for suicides, gun rampages take place within days of each other in summer.
Strengthening Global Health Systems: Jeanna Holtz (’79), Nutrition & Exercise Physiology
When Jeanna Holtz, Nutrition and Exercise Physiology alum, updated her estate plans, she found herself returning to the place where her journey began: Washington State University.
Stand Up for Science Demands Congress Stop Transfer of National Institutes of Health Research Funds to
New petition urges Congress to stop an interagency agreement that would allow health research money to fund War Department’s unspecified priorities.
Pritzker, Eyeing 2028, to Help Midterm Democrats With a $20 Million Group
JB Pritzker, the billionaire governor of Illinois, is continuing to expand his national footprint, this time by using a new group to target Republicans in battleground races.
Atlanta Braves Announce Pitcher News Before Rays Series
After splitting their four-game series with the Philadelphia Phillies, the Atlanta Braves remain 4.0 games up in the NL East. No off day for Atlanta, as they head home to face the AL East-leading Tampa Bay Rays in a new series this week. It’s another big litmus test for the Braves, as the series’ on […] The post Atlanta Braves Announce Pitcher News Before Rays Series appeared first on HEAVY.
Cowboys Predicted to Add Champion George Pickens Replacement
The Dallas Cowboys could have a high-scoring offense with George Pickens back. But assuming he leaves after this year, could a college star replace him? The post Cowboys Predicted to Add Champion George Pickens Replacement appeared first on HEAVY.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films.London, UK, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Sky Blue Cinematix, the entertainment and brand-integration division of Sky Blue Media Group, today announced its appointment as the exclusive global brand-integration partner for two upcoming feature films from Tested Films: the action thriller Habeas Corpus and the neo-noir romantic mystery Blurred. Sky Blue Cinematix appointed exclusi
Greg Schiano Announces AJ Surace Will Start vs. Boston College
Surace will make his first career start on Friday night.
Russia launches massive, deadly, and ‘complex’ attack against Ukraine
Fighting between Ukraine and Russia commenced after a 72-hour pause for diplomatic visits to both countries by U.S. officials. Russia launched a massive attack on Ukraine on Tuesday, firing dozens of cruise missiles and over 140 drones as the war raged on after this weekend’s peace talks brokered by U.S. envoys Jared Kushner and Steve […]
COMMENTARY: Tennessee loses Dodson, shifts focus to Georgia Tech
What must Tennessee do to leave Atlanta with a win?
From California to the Moon: Daniel Rivers and Sally Ashton Explore the Intersections of Art and Science NewsCenter | SJSU
Two new books from San José State faculty take on that question through explorations of environmental justice, space, California history and the possibilities of more just futures.
In 2018, scientists seeded clouds over China's Muz Taw Glacier to make snow; the brighter surface was followed by 14% to 17% less ice loss in a preliminary experiment
Researchers in China have tried to make artificial snow over China’s Muz Taw Glacier to slow its melting. The experiment conducted in 2018 involved seeding clouds with silver iodide, which helped trigger snowfall over the glacier.
Gone but not forgotten – Indigent Remains Ceremony 2026
The King County Medical Examiner's Office Indigent Remains Program provides burial for King County residents who have died without resources or family to claim their remains for a proper burial. The next ceremony to remember these individuals will take place on Wednesday, October 7, 2026, at 1 p.m. at Mt. Olivet Cemetery in Renton (100 Blaine Ave NE). It’s open to any member of the public who wishes to pay their respects.
The debate on whether WEC prioritised 'entertainment' over 'sport' in Austin
WEC hosted its Austin round last weekend, but did the series go too far in its pursuit of an entertaining race?
Small business optimism slips in August as sales, inflation concerns persist
Small business optimism declined in August as owners faced weaker sales, inflation and hiring challenges, according to NFIB’s latest survey.
Smithsonian head Lonnie Bunch to retire amid Trump administration effort to reshape institution
Lonnie Bunch III said Tuesday that he will retire as the head of the Smithsonian Institution, a role that placed him at the center of President Donald Trump’s efforts to reshape the world’s largest museum organization.
29 More Days Isn't a Business Plan (Opinion)
The one-month reprieve on the impending ban on many hemp products doesn't give small businesses enough time to make the decisions required to keep their companies running. Dylan Raap, CEO and founder of cannabis and hemp business Upstate Elevator, asks Congress to ‘tell us what the rules are and give us enough runway to live by them.’
Scientists Discover the 7 Stages a Meteoroid Goes Through Before Hitting Earth
An analysis of 75 meteorite falls identified seven distinct processes that occur as space rocks melt, break apart, and slow down before reaching the ground. A space rock entering Earth’s atmosphere does far more than simply “burn up.” By examining 75 meteorite falls recorded in videos and photographs, researchers identified seven distinct stages that shape
Chinese giants Xiaomi, Huawei race to get ahead of Apple’s rumored foldable iPhone
Xiaomi and Huawei launched new foldables ahead of Apple’s event, where the company is rumored to unveil its first foldable iPhone.
Business internship presentations connect classroom learning to career readiness
Nineteen Penn State Lehigh Valley business students concluded their required summer internships by presenting what they learned to faculty and staff evaluators. The presentations culminated a semester-long process designed to help students connect their academic preparation, workplace experiences and career-readiness skills.
The official sequel to The Ur-Quan Masters releases its free demo today
Blast your opponents in 1v1 arcade space battles like it's 1992 all over again.
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate
The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Live Results: Rhode Island midterm primaries
Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.
Celebrating 19 Years of Impact from One Iconic Desk
For nearly two decades, Administrative Assistant Carolina Rodriguez has been one of the first faces people see and one they remember at South Texas College’s (STC) Mid-Valley Campus. Long before titles or job descriptions, she became something harder to define but easy to feel: a constant presence, a listening ear and the heart of the campus.
New-to-science Amazon frog stands out for its slow ‘lazy’ song
Scientists recently described a new species of a tiny brown frog found in the Amazonian floodplain forests of Ecuador and northwestern Brazil. It looks nearly identical to related species but its slow, widely spaced out call sets it apart, researchers note in a study. “I’ve had to get into arguments because people said the frog […]
Live Results: New Hampshire midterm primaries
The race to replace retiring three-term Democratic Sen. Jeanne Shaheen is one of a handful across the country that could determine control of the U.S. Senate for the second half of President Donald Trump’s final term.
2026 Boolermaker Kids Race Registration Opens September 14
Kids can get ready for a spooky day of running and fun at the Boolermaker, which returns to T.R. Proctor Park.
Award-Winning Photographers Give Newhouse Students Up-Close Look at Covering Sports
Sony Artisans of Imagery Jean Fruth and Patrick Murphy-Racey provide advice, lead workshops at Syracuse football, Syracuse Mets games.
Jason Priestley recalls ‘flatlining’ in helicopter after 2002 near-death experience: ‘I bled to death’
The “Beverly Hills, 90210” actor crashed a car going nearly 180 mph while practicing for a race.
Norman Rock Creek Entertainment District faces lawsuit over tax increment financing
Norman's Rock Creek Entertainment District is a $1 billion project set to open in 2028, including a multipurpose performance venue, restaurants, retail space, office development, a hotel, and multiple housing options.
Sheff Utd sign experienced forward Ayew
Sheffield United sign former Crystal Palace and Leicester City forward Jordan Ayew on a deal until the end of the season.
Hidden camera found inside bathroom leads to arrest of Volusia County man, deputies say
He faces 10 counts of digital voyeurism and 11 counts of video voyeurism of a child.
40-goal Crystal Palace youth striker completes Arsenal transfer
Mylo Bernard has completed his transfer to Arsenal, with the Gunners confirming he’s joining on a scholarship deal with professional terms pre-agreed.Photo via Arsenal.comArsenal have officially ann...
Behind the scenes of Hard Rock Casino Tejon’s Third Eye Blind private concert
METTLER, Calif. (KGET) — An extra special concert took place Monday night at Hard Rock Casino Tejon. 17 News got an exclusive behind-the-scenes look at what it takes to prepare for the Third …
The Row brings new retail, dining and entertainment to Heartwood
The Row, a new in-line retail center located in Poplar Place within Heartwood’s Town District, will bring a growing mix of dining, entertainment, services and specialty retail to one of the community’s most visible commercial areas at Exit 82.
Rogers and OEG Sports & Entertainment Extend Strategic Partnership for 10 More Years
Rogers is giving away more than 1,500 tickets to customers throughout season, including 300 for Home OpenerEDMONTON, Alberta, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Rogers and OEG Sports & Entertainment (OEGSE), today announced a 10-year extension of their strategic partnership, keeping Rogers Place as the home of the Edmonton Oilers through 2036. This extension comes as the iconic Rogers Place is celebrating its 10-year anniversary. To mark the occasion, Rogers is awarding more than 1,500 Oilers ti
How the lowly egg could help protect future spacecraft
Bioinspired designs could be sturdy astronaut allies.
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
Pete Davidson reveals emotional 9/11 connection to Michael Strahan: ‘You put me on your shoulders’
In a new documentary, Davidson and Strahan recall and relive the happy meeting that took place amid tragedy and pain.
Rock Creek Entertainment District in Norman faces another legal battle
A judge will hear arguments on Tuesday as the legal battle over the $1.1 billion Rock Creek Entertainment District in Norman heads back to court.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Trump’s Bombardier threat puts aerospace supply chain at risk
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the U.S. In response, the maker of private jets noted that many components for its planes, including the wings, are produced in the U.S. and its supply chain relies heavily on U.S. companies. Since Canada-U.S. […]
Sunderland 'deserved more' at Brentford
Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.
Commentary: Who would want the US to be run like a business?
When pushing for the United States to be run more like a business, please keep in mind that framework naturally conflates the populace with labor and public servants with bosses. […]
Arkansas receivers did not impress, face a steep climb
The QB and the O-line are problems for Arkansas, but the receivers are, too
NASA Sea Level Science Makes Waves on World Ocean Day
Explore This SectionScienceScience Activation1,000 Museum Visitors Dive… OverviewResourcesOpportunitiesCitizen ScienceHighlightsAbout Science
Trump Boasts New Space Force Uniforms Are “Inspired” by ‘Starship Troopers,’ a Famous Satire of Nazism
Paul Verhoeven’s Starship Troopers literally wears its aesthetic influences on its sleeve.
Trump threatens Canadian jetmaker Bombardier
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States
Central Florida judge steps down amid political donation misconduct
The state Supreme Court recommended that Diana Tennis face suspension and a fine for giving to political groups while in office, rejecting an agreement with the state.
Juventus fans attack their team’s mindset over Federico Gatti’s celebration
Federico Gatti saved the day for Juventus when they faced AC Milan at the weekend, but his reaction after scoring has frustrated the club’s fans.The Bianconeri were the better team during the match,...
This Lafayette artist turns mud into the places people never want to forget
Over the years, Kai Drobish has has created items representing a lighthouse in Australia, a castle in Cuba, churches in Spain and Italy, hospitals in the United Kingdom, country houses in England and Scotland and a château in France.
'T Nation': More men turning to testosterone replacement therapy. What it means for health
In collaboration with the Hearst magazine, "Men's Health," WBAL-TV 11 News examines the increase in testosterone replacement therapy, and what it means for men.
Patriots make Christian Gonzalez the NFL's highest-paid cornerback, AP sources say
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment