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What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
Children's Minnesota doctor warns of Benadryl challenge dangers
Senate Indian Affairs Committee Advances Mark Cruz’s Nomination to Lead Indian Health Service
U.S. Senator Lisa Murkowski (R-Alaska), Chair of the Senate Committee on Indian Affairs, led a nomination hearing to consider Mr. Mark Cruz, of Oregon, to be Director of the Indian Health Service within the U.S. Department of Health and Human Services and expressed her intent to support his nomination. Representative Tom Cole (R-Okla.), a citizen […]
CRAWFORD | Kenny Klein, beloved longtime Louisville sports information director, dies at 66
Klein's career spanned nearly four decades and helped shape the public face of Cardinals athletics through some of its greatest triumphs and most difficult crises.
NBA fans troll Victor Wembanyama after MVP chants in France
Victor Wembanyama is back in France after leading the San Antonio Spurs to the NBA Finals. While his team failed to win the championship, he still received a lot of love from his countrymen. The 7-foot-4 center entered a club…
Trump nominates Chris Klomp as HHS second-in-command
President Donald Trump on Thursday named Medicare director and former health care executive Chris Klomp to be deputy secretary of the US Department of Health and Human Services.
Expanding camp adventure for all
A doctor works with Camp Michigania on making accessibility updates that are expanding and improving camper experiences.
“Vampire Diaries” stars Nina Dobrev and Paul Wesley reuniting for “You Deserve to Know” series at Hulu
The actors will star in and executive produce the upcoming show being adapted from the book of the same name.
21ALIVE SPORTS DIGITAL EXCLUSIVE: Loyer to the Clippers, TinCaps find second half success
21Alive Sports Director Andy Newman and Weekend Sports Anchor Nia Hinson catch you up on this week’s sports news.
Asthma, maternal health, climate disasters: How Detroit’s health director is tackling city’s health disparities
Detroit health director discusses tackling childhood asthma, maternal health, climate disasters through Health in All Policies approach.
Serious statin side effects on muscles are extremely rare, new research confirms
Scientists created a new tool to help doctors predict a patient’s risk of severe muscle problems from taking a statin.
Supreme Court hands Trump major victories on his immigration agenda
In two ideologically spit rulings that could affect millions, justices say the administration can deport some migrants and turn others away at the border.
WATCH: Kellyanne Conway insists socialist primary victories don't reflect American values nationwide
Kellyanne Conway says Democratic primary wins reflect only a handful of specific districts and do not signal a broader political shift nationwide.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Earthquakes Have Often Shaken Latin American Politics
How governments respond to natural disasters can shape their political trajectories, an expert writes.
Kurt Zellers out in shakeup at Minnesota Business Partnership
The lobbying group replaced with co-interim CEOs, a former state director for Amy Klobuchar and a Republican aide.
Rogers Computer Science Teacher Named Tops in the State
Instructor and coach, Anthony Hanos with members of the cyber security program, students Brandon Wilson, Kerian Santiago and Alex Bettencourt. The sister sectors of computer science, information technology and cybersecurity, continue to be among the fastest growing industries in the country, according to the U.S. Bureau of Labor Statistics. Luckily, Newport area high schoolers interested
EARLY CHILDHOOD EDUCATION ENDOWMENT ADVISORY BOARD APPROVES HEALTH INSURANCE SUBISIDY PROGRAM FOR EARLY CHILDHOOD EDUCATORS
EARLY CHILDHOOD EDUCATION ENDOWMENT ADVISORY BOARD APPROVES HEALTH INSURANCE SUBSIDY PROGRAM FOR EARLY CHILDHOOD EDUCATORS FOR IMMEDIATE RELEASE June 25, 2026 The Early Childhood Education Endowment’s Advisory Board voted on Tuesday to approve the new early childhood educator health insurance subsidy program beginning in 2027 and available through Access Health CT open enrollment starting October 23, 2026. Established into law…
Windows 10 support quietly extended until Oct 2027, as users reject Windows 11
Microsoft extends Windows 10 ESU for home users to October 2027, one year longer than planned. Here's the changes, the cost and how to enroll
Microsoft quietly extends Windows 10's extra security updates program for free: Users can now stay on Windows 10 until October 2027 securely
Windows 10's ESU program has been quietly extended by an extra year, now ending on October 12, 2027 instead of October 2026.
CBS Sports named this transfer as a potential X-factor for the Longhorns, and it may not be who you expect
The Longhorns’ CFP hopes could hinge on this transfer addition.
Health Care Roundup: Market Talk
Find insight on GSK and Fresenius Medical Care in the latest Market Talks covering the Health Care sector.
Supreme Court hands Trump two major immigration victories
Supreme Court rules migrants turned away at the border cannot apply for asylum and blocks TPS recipients from judicial relief in two major decisions.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Supreme Court sides with big business in Roundup cancer risk fight
The ruling is also a victory for the Trump administration and a defeat for the Make America Healthy Again movement.
Supreme Court sides with big business in Roundup cancer risk fight
The ruling is also a victory for the Trump administration and a defeat for the Make America Healthy Again movement.
David P. O'Brien
About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.
Moody Center announces exhibition exploring math, science and tech rooted in Indigenous knowledge systems
Through a framing of North, Central and South America as interconnected regions, “Radiant Geometries: Vectors of Knowledge from the Indigenous Americas” brings together contemporary Indigenous and Latin American artists whose practices illuminate knowledge as a living technology, through which the mathematical, metaphysical and artistic realms converge.
CU Director of Sports Medicine Dr. Eric McCarty Provides Capitol Hill Briefing on College Athletics Landscape
The University of Colorado's Director of Sports Medicine Dr. Eric McCarty was among a prestigious panel of physicians and coaches leading a briefing on Capit...
Hackensack Meridian Health Graduates Largest Number of Residents and Fellows Yet for Network
314 doctors continue their quest to be the best clinicians possible within New Jersey’s largest and most comprehensive health network
How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
The Heart-Healthy Way to Lift Weights, Explained by a Doctor
In TODAY.com’s Expert Tip of the Day, a sports medicine doctor reveals whether it’s better to use heavier weights with fewer reps or lighter weights with more reps for a healthy heart.
Memphis People in Business for June 25, 2026
A look at promotions, hirings, movers and newsmakers in the Memphis area business scene
Keiser's Paul Dodson Voted 2025-26 SUN Sports Information Director of the Year
The Sun Conference is pleased to announce that Keiser University Assistant Athletics Director of Communications Paul Dodson has been named the 2025-26 Sun Conference Sports Information Director of the Year, as voted on by his peers across the league. The honor marks the third conference SID of the Year award of Dodson's career after previously earning the distinction in 2022-23 at Keiser University and 2018-19 while at Johnson & Wales University.
This Doctor Can Change the Color of Your Eyes. Should He?
Francis Ferrari, a French ophthalmologist, invented a controversial procedure that can change eye color. People from around the world are willing to take the risk.
Lewis Hamilton's Barcelona win draws Ferrari warning from Guenther Steiner
Guenther Steiner has urged Ferrari to stay grounded and build on Lewis Hamilton’s Barcelona victory
Politicians love 'affordability' rhetoric. But it hasn't offered path to urban prosperity in Kansas.
Wichita remains one of the most “affordable” regions to inhabit in the U.S. today, but that affordability has not served as as economic boon.
‘Long-term Thinking Is Key To Ensuring Cultural Relevance’: Q’s With Gadget Entertainment Group’s Stefan Wyss
Gadget is one of Switzerland’s longest-standing promoters, having celebrated its 30th anniversary in 2024. In 2020, after already collaborating successfully
Prime Day 2026 LIVE: our home cinema experts' picks of the best OLED TV, Dolby Atmos soundbar, projector deals and more
We’re recommending the top savings, on and off Amazon, in real time
Who gets to decide Colorado’s economic future?
By Sarah Blackhurst Colorado’s prosperity depends on industries that grow our food, build our future and power our homes. But today, these sectors face an invisible threat from 5,000 miles away: the European Union’s Corporate Sustainability Due Diligence Directive (CS3D). This foreign regulation requires companies to mitigate environmental and human-rights effects throughout their entire global […]
Rubio reassures Gulf allies as US-Iran talks advance
Tehran has already portrayed the deal as a victory
Closed-door outburst turns into victory for Trump’s Iran negotiations
Senate Republicans flipped to reject Democrats' Iran war powers resolution, handing Trump a key win as U.S.-Iran peace deal talks continue on.
Louisville doctor, nurse and nonprofit founder charged in federal health care fraud crackdown
Federal prosecutors in the Western District of Kentucky announced charges in four separate cases involving alleged schemes to defraud Medicare and Medicaid, misuse medical credentials and controlled substances, and submit
Mamdani's sweep in New York a 'political earthquake' among Democrats
New York City Mayor Zohran Mamdani scored a massive political victory on Tuesday when his trio of insurgent congressional candidates toppled two incumbents and the establishment favorite in an open seat, results some described as "a political earthquake" for Democrats.
Factory Entertainment Unveils Four 2026 STAR TREK Convention Exclusives, Preorders Open Now
Factory Entertainment’s 2026 convention-exclusive STAR TREK goodies are here, with four new items available for preorder today
Netanyahu’s growing unpopularity, angering Trump, boosts Mamdani’s pro-Palestine candidates for Congress
Netanyahu faces criticism over Gaza and Iran, pro-Palestinian candidates score major victories in New York politics.
Where health begins
Dean Bernadette Boden-Albala has spent her career exploring the factors that affect well-being long before disease develops
20 everyday habits that affect your heart health
Cardiovascular disease is the world's leading cause of death — and most of its risk factors are behavioral, not genetic. These are the daily habits that matter most
Star Fox Nintendo Switch 2 voice actors revealed, including Fox, Falco, Peppy, Slippy, and more
The full Star Fox Nintendo Switch 2 cast has now been revealed, and here are the new voices for Fox, Falco, Peppy, Slippy, and more.
An emboldened hard left eyes Schumer challenge
The Democratic Senate leader is staring down a tectonic shift in his home state.
Highlights of Aspen Ideas: Health, day two
On June 23, Aspen Ideas: Health ushered in the actual first full day — and evening — of programming. Here are some highlights from different tracks, or themes. NextGen Health Track: On the Frontiers of Brain Health “As belly size gets larger, the memory center in the brain gets smaller,” said Richard Isaacson, director...
How Brexit broke British politics
Brexit has had a lasting impact on British politics, causing a decade of turmoil and division, and resulting in the resignation of Prime Minister Keir Starmer after two years of economic stagnation and a divided electorate.
Tennessee parents, doctors warn of law aimed at excluding ill undocumented children from public medical program
A Tennessee law requires the health department to share the immigration status of a child with state authorities if they’re enrolled in the Children’s Special Services program.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
Sony Pictures Entertainment Invests $100 Million, Takes Minority Stake in Cosm
Sony Pictures Entertainment Chairman and CEO Ravi Ahuja will also join the immersive entertainment company's board of directors
OHSAA names girls flag football as 29th recognized sport
The OHSAA Board of Directors voted at its June meeting for it to become the 29th recognized sport
OHSAA names girls flag football as 29th recognized sport
The OHSAA Board of Directors voted at its June meeting for it to become the 29th recognized sport
Science Day 2026 at the HLPF: The science-policy imperative in the final stretch to 2030 and beyond
Science Day convenes scientists, policymakers and societal actors at the HLPF to examine science's role in accelerating SDG delivery to 2030.
455 people including doctors charged in historic $6.5B health care schemes
Over 450 people, including 90 medical professionals, are facing charges in global health care fraud schemes totaling $6.5 billion.
Partnership to Launch $280 Million Mixed-Use Entertainment District Surrounding Neyland Stadium in Knoxville
Knoxville, Tenn. — A public-private partnership between the University of Tennessee and a newly formed development platform comprising Arctos, RVX - Development, Entertainment, Mixed-use, News, Tennessee
Tongue Cancer Survivor Reunites with ICU Doctor Who Helped Save Her Life
After a life-threatening complication from tongue cancer surgery led to septic shock and organ failure, high school teacher Jennifer Quick spent nearly a month in the ICU at Atrium Health.
Program Director Shares How Articulation Agreements Benefit Meredith Pre-health Post-Baccalaureate Students
Karthik Aghoram, director of Meredith’s Pre-health Post-Baccalaureate Program, recently spoke with Inspira Advantage about the program’s articulation agreements and why they are valuable for students seeking careers in health care.
Girls Flag Football is Now OHSAA’s 29th Recognized Sport
OHSAA Board of Directors voted to add girls flag football as a fully sanctioned sport
NFL offseason power rankings: No. 31 New York Jets try to put Aaron Glenn's horrific first season behind them
Political earthquake: 5 key takeaways from New York’s Democratic primaries
A trio of progressive insurgents backed by New York City Mayor Zohran Mamdani claimed victories in House primaries. Here’s what to know.
Darializa Avila Chevalier: pro-Palestinian doctoral student steps into politics with ‘faith in the future’
Mamdani-backed candidate won New York’s 13th congressional district with no experience in office but ideas for how politics can ‘actually invest in life’
Mamdani-backed primary sweep further cements anti-Zionist politics in NYC
Election wins continue anti-Israel far left's upward trajectory in the city, and send a message to the Democratic Party leadership
Financing the Future: Leaders Make the Investment Case for Women's, Children's and Adolescents' Health
With development assistance declining and health systems under growing strain, leaders at Africa Health ExCon called for a shift from fragmented financing to integrated, sustainable investment in women’s, children’s and adolescents’ health. Discussions highlighted domestic financing, private sector engagement, service integration and climate-resilient health systems as pathways to greater impact.
Banks Joins Sports Performance Staff
The UNCW Athletics department has announced the addition of Dr. Quadrian Banks as an Assistant Director of Sports Performance on Wednesday.
BBC announces new Entertainment commissioning structure
Under Ed Havard, the BBC’s Director of Entertainment, the new commissioning model will be organised around three genres
How wearable tech aims to innovate women's health care
Clair Health co-founder and CTO (Chief Technology Officer) Abhinav Agarwal comes on Asking for a Trend to explain how the company is using AI models in its hormone monitoring device and how new doctors, specifically OBGYNs, can use it to learn more.
Megan McKnight named director of Health Promotion and Wellness at Penn State
Megan McKnight brings extensive experience in health promotion, prevention education and student well-being initiatives to her new role as director of Health Promotion and Wellness at Penn State, effective June 29.
France Identifies First Case of Ebola
The patient is a doctor who had traveled to the Democratic Republic of Congo, the health ministry said. Workers are racing to trace those who may have had contact.
Live updates: Progressives score wins in New York; Trump to sign housing bill
Get live updates and the latest news as progressives score election victories in New York and Trump signs a housing affordability bill.
A staunch voice in support of science
Jeff Coller, a pioneering RNA biologist, has spent the past year vehemently advocating for the lifesaving promise of research in the face of federal cuts
France confirms first Ebola case in doctor returning from DR Congo
The patient is in isolation, following strict biosafety protocols to prevent risk of spread in France.
Entertainment calendar
Please email entertainment listings to entertainment518@digitalfirstmedia.com. Wednesday, June 24, 2026 PROCTORS: 432 State Street, Schenectady. Chicago, 7:30 pm. www.atproctors.org. SARATOGA PERFORMING ARTS CENTER: 108 Avenue of The Pines,…
Victories by Pro-Palestinian Democrats Show the Party’s Shift on Israel
Three Democrats who have been outspoken in their criticism of Israel won primaries in New York on Tuesday, signaling their party’s new skepticism of the country and its actions.
The Wearable Data Your Doctor Actually Wants
Wearables can offer rough information about a person’s health, experts say, but only some metrics are medically useful.
Podcasts are Changing the Doctor-Patient Dynamic. Is That a Good Thing?
The dynamic in the exam room is changing as more people show up ready to talk about what they’ve heard on podcasts.
Central Florida restaurants forced to shut down over health concerns
Last week, another six Central Florida eateries were told to close after a visit from a health inspector, according to state records.
Death Row Disability Cases Are Questions of Morality, Not Science
Doctors’ input on how to weigh cognitive disability in death penalty cases can be helpful, but characterizing such judgments as science misrepresents medicine and psychology, says Dr. M. Gregg Bloche of Georgetown Law.
Saipem to sell Saudi shallow-water drilling business to ADES for $285 mln
Italian energy contractor Saipem has agreed to sell its shallow-water offshore drilling business in Saudi Arabia in a deal worth $285 million, the company said on Wednesday.
Mamdani Emerges as Kingmaker, Pushing His Slate to a Primary Sweep
Mayor Zohran Mamdani shook the Democratic establishment by helping drive three progressive candidates to victory.
Trump’s acting chief of national intelligence fires 6 political appointees, removes dozens of career officials, sources say
Acting Director of National Intelligence Bill Pulte has fired six political appointees put in place by former Director Tulsi Gabbard and removed dozens of career intelligence officials from their roles, according to four sources familiar with the moves.
NBA Draft: Spurs beef up with shot-blocking Kentucky F Jayden Quaintance, UConn C Tarris Reed Jr. to play with Victor Wembanyama
Daughter of Oscar-winning director found dead with husband in car
Judith Sheldon, daughter of Oscar-winning 'Ben-Hur' director William Wyler, was found dead with her husband Wylie Sheldon in their car along the side of Interstate 5 near Redding, Calif., on June 15.
3 people in Oklahoma indicted in nationwide health care fraud probe
Three people in Oklahoma were indicted in a nationwide health care fraud probe involving nearly 500 people, including dozens of doctors.
Tickets for top entertainment events at Scotts Bluff Co. Fair go on sale Wednesday
Tickets for the ‘big three’ of the nightly entertainment at the Scotts Bluff County go on sale Wednesday morning. Starting at 9 a.m., you can get your advance tickets for the Truck and Tractor Pull…
Clarksville former doctor charged in nationwide DOJ healthcare fraud crackdown
A Clarksville former doctor is part of a nationwide healthcare fraud crackdown by the federal government.
Trump touts falling oil prices, economy at Pennsylvania rally
The president spoke at a Mack Trucks factory in Macungie on Tuesday
Trump touts falling oil prices, economy at Pennsylvania rally
The president spoke at a Mack Trucks factory in Macungie on Tuesday
Trump touts falling oil prices, economy at Pennsylvania rally
The president spoke at a Mack Trucks factory in Macungie on Tuesday
Meta Thinks 'Social Learning' Can Fix Smart Glasses' Privacy Problems
Meta's CTO, Andrew Bosworth, suggests privacy expectations about smart glasses will be decided in the court of public opinion.
Kansas Democratic gubernatorial candidate's union membership sparks political finger-pointing
Democratic candidate Cindy Holscher's membership in the KNEA union raises an alarm in union-endorsed rival Ethan Corson's campaign for governor.
DOJ announces $6.5B healthcare fraud takedown with record Medicaid enforcement
The Department of Justice unveiled charges against 455 people, including 90 doctors and other licensed medical professionals, for their alleged participation in healthcare schemes that involved mor | Law enforcement unveiled charges against 455 defendants for their alleged participation in healthcare schemes, among which fraudulent amniotic wound allografts and undelivered Medicaid services were spotlighted.
Meet Caramelo, the Mexico superfan attending his 11th World Cup
Long after Mexico’s World Cup win against South Korea, fans young and old lined up outside the stadium to take photos with Héctor Chávez and his big black sombrero. Also known as Caramelo, candy in English, Chávez is arguably as well-known in Mexico as the members of the national team. Now at his 11the World Cup, Chávez is flanked by his 21-year-old son, also called Héctor Chávez, and known as Caramelo Jr. Both wear oversized sombreros with their nicknames written in all caps, making them hard to miss at stadiums.