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Chivu: “The boys gave everything right to the end”
Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
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Googlebook is getting AAC Bluetooth audio and key fixes for Cast My Apps
As we talked about earlier this week, every brand-new platform goes through growing pains right out of the gate, and Googlebook OS is no exception. While we've already seen Google step up to...
Cost of employer-sponsored health insurance rises again, survey finds
WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Jennifer Hawks explains why she should be California's State Treasurer
Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
California Politics 360 full episode | Clash over voter rolls heads to court
On Tuesday, one week before the election, a federal judge will determine the next steps.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones
Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Xbox Asked for $800 Million After Netflix Offered $500 Million for Game Adaptation Rights
Netflix offered Xbox $500 million for seven years of exclusive film and TV rights, and Xbox countered with $800 million, Puck's newsletter…
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots
The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.
Google's next TV gadget may do much more than stream
A reported hardware overhaul could bring Gemini further into the living room.
Syria’s Democratic Transition: Building Institutions Alongside Political Competition
Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,
Florida political leaders mourn after shooting at FAMU homecoming
Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.
Robinson, Baker have tough talk about the offense
Robinson, Baker have tough talk about the offense
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream
Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.
Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.
On Christ the King and the idolatry of politics
Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Postpartum recovery window may play a critical role in maternal aging and long-term health
In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
Three Days Grace in San Antonio: What to know
The Canadian rockers are bringing their Alienation Tour to town. Here are the details on tickets, parking and more.
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known
A "thick and peculiar" cephalopod.
MCHD: Several people treated at local emergency rooms for bat bites in Baldwin County
The Mobile County Health Department says the patients were bitten at different residences in Baldwin County.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Campbell County health and food inspections (10/16/26–10/22/26)
GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]
Laramie County health and food inspections (10/16/26–10/22/26)
CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts
Natrona County health and food inspections (10/16/26–10/22/26)
CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and
Rep. Haley Stevens sidesteps whether she still supports El-Sayed, criticizes outreach to Black voters
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake
The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.
AI-generated video heats up suburban Texas political clash
Fort Bend County has seen plenty of controversy at its highest levels.
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman
The Michigan governor did not deny that she was exploring a potential run for president in 2028.
What Chelsea Did Wrong vs Tottenham
After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list
Aaron Rodgers now sits third all-time in passing touchdowns.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Face the Facts: New health insurance helps early childhood educators
Child care is expensive, and keeping qualified workers on the job is part of the challenge. Now, Connecticut is offering a new health insurance subsidy to help early childhood educators lower their monthly premiums. Rep. Kate Farrar (D-West Hartford) explains how it works and why it could make a difference for families. Mike Hydeck: For years, Connecticut has had among…
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K
13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.
GeForce Unlocked: Modders Boost RTX 20, RTX 30, and RTX 40 Compute Performance by Up to 2x
NVIDIA's GeForce RTX 30-series and RTX 40-series graphics cards are based on the same dies as their professional-grade GPUs. This means the compute potential of consumer-oriented RTX GPUs is restricted by NVIDIA's firmware stack, but modders have managed to unlock the instruction issuing rate...
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.
Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future
Soldiers and others suffering from post-traumatic stress disorder […]
October 7 should have changed Israeli politics, yet we are voting for the same leaders
Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
9 Cool Camping Features Built Into Oliver Travel Trailers (And 3 You Can Add Yourself)
The utility you can get with an Oliver Travel Trailer these days will surely enhance your next camping trip, but there is even more than meets the eye.
PS5 Answers 'Bleakest' Month with a 22% Upswing in Sales
How much does the enthusiast discourse matter?
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
The science and politics behind the panic over ultraprocessed foods
The very definition of ultraprocessed is highly contested.
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Some Thoughts About Ron Duguay
Dear, departed Ron Duguay was not anything like his playboy image.
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’
The Heat’s Giannis Antetokounmpo era is off to a rough start.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
Oprah on the Health Metric We Should All Be Tracking
“These facts are a wakeup call for all of us to get serious about our heart health.”
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Ranked: Countries With the Most Trust in Science
Discover which countries trust science the most and least in 2025, and how education, religion, and culture shape public confidence.
Michigan's Jason Beck promised change, but numbers tell another story
Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.
Roots music fest fun in downtown Yadkinville
Click here to view this article from yadkinripple.com.
Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer
About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
17 Celebrity Transformations That Left Fans Doing A Double Take
From Avril Lavigne's “soft makeup era” to JoJo Siwa’s “clean girl” aesthetic, these wild celebrity transformations will leave you gagged.
Silicon Valley software engineer pay ranked against other US cities
Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Stop Chasing Views: How 87% of Creators Are Using AI to Build Real Businesses Beyond Social Media
87% of creators say AI is growing their business. Here's how creators trade social media algorithms for owned commerce and real enterprises.
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign
The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]
31 'Brooklyn Nine-Nine' Memes That Would Win a Halloween Heist and Become the Ultimate Detective/Genius
These memes are noice!
Nuthatches are rude: Ornithological observations from a recliner
I don’t know what age you’re supposed to start sitting in a recliner and looking out the living room window at the bird feeder, but I sure do like doing
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
Culture House Wants to Turn Creator Connections Into Lasting Businesses
Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
Evan Mobley on Jarrett Allen: “The team loves it. …
Evan Mobley on Jarrett Allen: “The team loves it. …
Khaman Maluach: “It’s different. Draymond Green is …
Khaman Maluach: “It’s different. Draymond Green is …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"Jakucionis, he's family. He's an incredible player," …
"Jakucionis, he's family. He's an incredible player," …