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Asher Grunis steps down from leading Submarine Affair commission due to health concerns
Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.
Nigeria widens hunt for possible Ebola cases
Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...
Made in Tarrant: Family turns sports card hobby into baseball stadium business
Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.
Made in Tarrant: Family turns sports card hobby into baseball stadium business
Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.
BCM hosting special Nov. 13 show for America 250
BRISTOL — In partnership with The Crooked Road: Virginia’s Heritage Music Trail, Mountain Empire Children’s Choral Academy, and Theatre Bristol, the Birthplace of Country Music Museum is bringing together an
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record
'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
Senate rivals seek support from Alaska Native voters
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election
Broncos Place Linebacker, Running Back On Injured Reserve
The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race
WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex
West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
In Texas Senate Race, Talarico Leans Into Growing Rivalry With Elon Musk
On the trail, James Talarico, the Democratic Senate nominee, has increasingly gone after Mr. Musk, a critic of his who has given big to a group aligned with the Republican candidate, Ken Paxton.
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily
Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
Three Days Grace in San Antonio: What to know
The Canadian rockers are bringing their Alienation Tour to town. Here are the details on tickets, parking and more.
Face the Facts: New health insurance helps early childhood educators
Child care is expensive, and keeping qualified workers on the job is part of the challenge. Now, Connecticut is offering a new health insurance subsidy to help early childhood educators lower their monthly premiums. Rep. Kate Farrar (D-West Hartford) explains how it works and why it could make a difference for families. Mike Hydeck: For years, Connecticut has had among…
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
October 7 should have changed Israeli politics, yet we are voting for the same leaders
Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Fernandes dropped: Man United name team to face Bournemouth
Manchester United have named their team to face Bournemouth in the Premier League, with captain Bruno Fernandes dropped from the side.Fernandes has been named among the substitutes at Old Trafford, in...
Liverpool host Brighton; Man Utd take on Bournemouth in PL
2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...
Saints vs. Steelers in Paris: Week 7 game chat
The Saints face the Steelers in this Week 7 matchup. Join us here for the game!
Guardians Middle Infielder is a Prime Trade Candidate
The Cleveland Guardians, fresh off an ALCS appearance, will be facing several tough decisions next season regarding their lineup. The 85-win team won their division and looks poised to repeat next year, but they face an enviable dilemma. What do they do with their influx of top, young talent, and how do they find them …
Business lessons are coming to liberal arts schools
A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.
AP Business lessons are helping high school students learn how to manage money
A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.
Local breakfast chain plans Derby expansion
The Easy Egg, a Wichita-based breakfast and lunch restaurant, recently announced plans to expand into Derby. Reports indicate the local chain will take over the space at 317 N. Rock
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
🚨 Barça's squad to face Real Madrid
Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...
A doctor traded health insurance for direct primary care, cost-sharing
A doctor explains why he replaced traditional health insurance for his family of four with direct primary care and a medical cost-sharing group.
Sources: Leeds hit by new hurdle in Nicolo Tresoldi race
Daniel Farke in a press conference with Leeds, with Paraag Marathe at Elland Road
Political analysis favors Mendoza over Ciscomani
The Cook Political Report has switched its assessment of the congressional race for the House seat from a “toss-up” ranking to “Leans Democratic.”
Politics chat: The polls show a Democratic sweep in the midterms. Can you trust them?
If you look at the few truly competitive seats, polls show a more complicated picture of momentum toward the Democratic Party in midterm House races. For the Senate, Republicans are on defense.
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
Cuts to rural healthcare become key issue for upstate votes in race for NY governor
The fight over a consolidation plan for a hospital in Hudson captures a trend throughout the state.
Seamus Power, Austin Smotherman Share Lead In Windy Bermuda Showdown
Seamus Power and Austin Smotherman share the Bermuda Championship lead at 16 under, with fierce winds and PGA Tour playing privileges adding drama to Sunday's finale.
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
What voters need to know about the races for Florida’s Cabinet positions
The Florida Cabinet consists of the attorney general, chief financial officer and agriculture commissioner.
WSL: Crystal Palace host Chelsea in first of five games
Follow live coverage of Crystal Palace host Chelsea in the first of five Women's Super League games on Sunday.
College football scores yesterday: Results of top 25, notable games
More ranked teams lost to unranked foes in Week 8. Here are the scores from top 25, other notable matchups that took place in Week 8.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
NFL.com Experts Rolling With Broncos In Week 7
Fresh off a gritty win, Denver faces an injury-riddled Arizona squad as analysts eye a potential breakout performance for Bo Nix against the struggling Cardi...
Powers Health Community Hospital Achieves Statewide Milestone in Treating Heart Valve Conditions
Powers Health Community Hospital has successfully performed Indiana’s first procedure using the SAPIEN M3™ transcatheter mitral valve replacement (TMVR) system, a minimally invasive treatment for …
What we learned about our politics in the 2026 Texas elections
From the governor's race to local offices, the culture wars gave way to public education and property taxes.
BREAKING: Courtois out against Barcelona
Real Madrid have announced that goalkeeper Thibaut Courtois will not play against FC Barcelona tonight. Per Realmadrid.comCourtois is a last-minute drop due to a flu process for tonight’s match between Real Madrid and Barcelona, corresponding to the tenth round of the League. Illia Voloshyn enters the squad list in his place. This is devastating news […]
Why Mikel Arteta is right about Max Dowman
Mikel Arteta has faced some pushback on his recent comments about Max Dowman, but the Arsenal manager was right to suggest that what the 16-year-old is doing is unique.Photo by Julian Finney/Getty Ima...
AC Milan XI vs Udinese – Predicted lineup and team news
AC Milan will look to break into the Serie A’s top four by taking maximum points when they travel to face Udinese on Sunday in their upcoming league fixture.The Rossoneri arrive with a mixed and unp...
Health centers brace for new Med-QUEST rules
Starting Jan. 1, most adults enrolled in the government’s Medicaid program will have to show they work, volunteer or go to school part-time at least 80 hours in a month to qualify for healthcare under Med-QUEST, Hawaii’s Medicaid program.
I wish GM, other automakers, would've picked up on hybrids
Freep readers respond to Editorial Page Editor Nancy Kaffer's latest column, Michigan's U.S. Senate race and other news of the week.
This fifth-generation family business in rural Pa. is making 4,500 brooms for Salem
On Etsy, the Meckleys have made close to 20,000 sales.
Cosmic 'seagull' locks eyes with the Vera C. Rubin Observatory in long-awaited test image — Space photo of the week
Stare into the transfixing eye of the "Seagull Nebula" in this newly-released test image from the visionary Vera C. Rubin Observatory.
What lymphatic drainage tools can and can’t do for your health
Influencers swear by lymphatic drainage to allegedly reduce puffiness, contour their faces and bodies, and boost overall health. We asked experts if you should just save your money.
Islanders Gameday News: Starting in Dallas; Hellebuyck moves next door
The Islanders have touched down in Dallas for a Sunday night encounter, where Pete DeBoer will be the story as he faces his most recent former team. The Stars are in their 1980s Capitals era (or more generously, 1980s Flyers), perennially fielding really good teams but finding different reasons and divine interventions to prevent their […]
Winner and Loser of the Week in Florida politics
Ben Albritton bails on Amendment 3, Jackie Espinosa faces fraud charges, and St. Pete gets its (final?) World Series moment.
Guest Commentary: How anti-Muslim politics endangers every Floridian
The political caricature of Muslims as a national security threat bears little resemblance to the reality that Floridians are living, working, and raising families in peace with nearly half a million Muslims woven into the fabric of the state.
Outside View: Sensible steps on health care caused uproar. Now the numbers are in
By Washington Post Editorial Board
Pols & Politics: Questions raised in recent polling on Gov’s race as RNC survey shows tight matchup
Recent polls on the upcoming race for Massachusetts Governor, which showed double-digit leads for Gov. Maura Healey over GOP challenger Mike Minogue, have raised questions on their methodology.
Peoria businesses face dilemma at plaza owned by healthcare giant
The sale of MidTown Shopping Plaza to OSF HealthCare has left local business owners on edge. It has led to uncertainty, stalled investments and tenants bracing to start over elsewhere.
Democrats Have Edge Across Four Key House Races in Pennsylvania, Polls Find
Democratic candidates are ahead in two, hold a narrow edge in a third and are tied in a fourth, new polling shows. The seats embody the fights playing out nationwide in the midterms.
Democrats Bob Brooks, Paige Cognetti lead GOP incumbents in pair of key Pa. swing seats
Republicans are on pace to lose the two U.S. House seats they flipped just two years ago, according to a new Inquirer/New York Times/Siena University poll.
The boss whose twice-bust business appears to be back despite £3m debts
Andrew Woosnam took millions from his companies before leaving creditors including HMRC out of pocket
In Deep Red Kansas, a Trump Loyalist Fights to Defend a Senate Seat
Senator Roger Marshall was slow to recognize the steep challenge he faced in his solidly conservative state. Now he is confronting dissent among voters with deep economic worries.
Business briefs: Harry Reid airport completes $71 million baggage upgrade
In Terminal 1, the work included upgrades to eight baggage carousels, replacement of eight others, new conveyors and new carousel columns with LED screens. In Terminal 3, the project upgraded the computer hardware and software that control the baggage system …
Trump started a trade war with Canada. GOP candidates became casualties.
High tariffs on Canadian goods have turned into a liability for Republicans in key midterm races, particularly those in northern border states.
Guest opinion: Partisan politics don’t belong in Montana’s courtrooms
As retired district court judges who worked in courtrooms across Montana, we know there is no Democratic or Republican way to handle the everyday court cases Montanans face. That’s why we support Constitutional Initiative 132 to keep our judicial elections nonpartisan.
Union to Dedicate Historic Marker Commemorating Battle of Connecticut Farms as Part of America's 250th Celebrations
Union – The Township of Union Planning Committee for the 250th Anniversary of the United States, in partnership with the Union Township Historical Society, invites residents and history enthusiasts...
Inside a California shopping center's struggle to reinvent mall food
LOS ANGELES — Westfield Topanga is one of Southern California's most popular malls, but it has grappled with what to do with the empty space left when it lost its
Hibernian vs Celtic – Match preview and team news
Celtic will look to bounce back from their recent European defeat as they travel away from home to face Hibernian in their next Scottish Premiership match on Sunday.Hibernian vs Celtic – Match prev...
Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid
The Toronto Maple Leafs and Edmonton Oilers are facing one another in a Saturday evening showdown at Edmonton’s Rogers Place, marking the first time in the career of rookie forward Gavin McKenna that he’s facing Edmonton superstar captain Connor McDavid.McKenna, who has previously trained with McDavid over the summer, remains as much in awe of […] The post Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid appeared first on HEAVY.
Salt Lake City Christmas tradition ends after 30 years as owner faces health challenges
Forrest Nunley, the man behind a beloved Christmas house tradition in the Salt Lake Valley, is turning off the lights for good.
Clemson HC Dabo Swinney Puts Coach on Notice, Offense 'Disturbing'
After a deflating loss to Virginia Tech, Swinney confronts roster gaps and coaching failures as the Tigers' playoff hopes vanish and the offense faces a critical crossroads.
Kochetkov Earns Shutout
Pyotr Kochetkov improved his record to 7-0-0 with a 24 save shutout and the Carolina Hurricanes defeated the St. Louis Blues on Saturday night, 4-0. The Hurricanes now have a 9-2-2 record and their 20 points put them at first place in the league, (for now). The Canes finished up their road trip with a […]
Bruins vs. Sharks Takeaways: Boston Rallies for 6-4 Win
Boston erupted for four goals in the third period to secure a comeback win over San Jose. David Pastrnak reached a major franchise milestone as the Bruins extended their point streak to eight games.
Pokémon GO's Season of Twilight Trails' Pokémon Night Out 2026 Twitch Drops event guide
As part of Pokémon's 30th anniversary, a new music event will be taking place in Los Angeles, California and London, United Kingdom. Dubbed Pokémon Night Out,
Colts make roster moves ahead of road matchup vs. Minnesota
The Colts are elevating a familiar face at linebacker to their active roster ahead of Sunday’s road game.
Black Power Marketplace highlights Black-owned businesses in Rochester
Rochester, N.Y. — The Community Justice Initiative held the Black Power Marketplace, which featured local vendors that offered food, clothes, art, wellness serv
Ramaswamy ad puts Acton’s estranged mother in spotlight as records reveal family’s troubled past
Vivek Ramaswamy faces bipartisan backlash over an ad featuring Amy Acton’s estranged mother, whose rocky history emerges in court records and interviews.
🥈 Bullet header places Antoine Griezmann in MLS goalscoring pantheon
Antoine Griezmann's arrival in MLS has come up with the goods in expected fashion across much of the 2026 season, with the World Cup winner and France icon becoming one of the faces of the league and ...
Vikings Return from Bye to Face an Imploding Colts Team
5-0 Vikings need more from Kyler Murray. Colts in turmoil. Trade deadline looms. Get Better or Bust.
Sullivan, Peltola seek support from Alaska Native voters ahead of crucial Senate race
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election.