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Phillies Get Update On Triple Crown MVP Free Agent Target
The Philadelphia Phillies are linked to a superstar infielder who will officially become a free agent option in the offseason.
SpaceX quarterly revenue jumps, beats estimates as AI business surges
Oct 20 (Reuters) - Elon Musk's SpaceX on Tuesday said its third-quarter revenue more than doubled, beating estimates as AI and Starlink grew, while capital spending nearly tripled as it invested in compute infrastructure, sending its shares up about 3%...
Spanberger demands 6-year rate freeze in Dominion merger
Gov. Abigail Spanberger called for the Virginia State Corporation Commission to reject the $67 billion merger between Dominion Energy and Florida's NextEra Energy unless the two utilities agree to freeze residential power rates for six years and triple monthly customer bill credits.
A gene variant triples the risk of getting Alzheimer's disease — fat buildup in brain cells may be to blame, study finds
A gene variant called APOE4 is the biggest genetic risk factor for Alzheimer's disease. Scientists are finally figuring out how it works.
Omar Cooper Jr. hits triple digits in Week 6 vs. Patriots
New England Patriots wide receiver Omar Cooper Jr. had six receptions for 103 yards and a touchdown on a team-high seven targets in Week 6
Rabies reports are rising in California. Experts can’t explain why
Rabies reports are up across the U.S., including in one greater Bay Area county where human exposures to rabid animals have tripled, prompting a local advisory to stay away from sick creatures.
Triple stabbing survivor calls for more mental health resources in Boston
Your Weekly Michigan Political Brief
U.S. Senate Abdul El-Sayed more than tripled the fundraising haul of his Republican challenger, former U.S. Rep. Mike Rogers (R-White Lake), for Michigan’s open U.S. Senate seat. Online records show El-Sayed raised $30,659,157 in the reporting period from July 16 to Sept. 30, while Rogers brought in $9,662,538. Despite that, Rogers’ campaign maintains a nearly […]
Yankees get $120 million prediction for NPB Triple Crown winner
The Yankees are a potential landing spot for the NPB star.
Drinking 'Very' Hot Tea or Coffee Could Triple Your Risk of This Cancer, Huge Study Finds
The largest study of its kind to date.
The 20 best ‘Tales From the Crypt’ episodes, ranked
From Robert Zemeckis’ killer Santa to Tim Curry pulling triple duty, HBO’s ‘Tales from the Crypt’ delivered some deliciously demented television. We rank its 20 best episodes.
Nebraska rifle falls below .500 for first time in three seasons
The Nebraska rifle team, which is fourth-ranked in the nation, has tripled its loss total from the 2025 season. For the first time since February of 2024, the team has fallen below .500.
Watch: Alperen Sengun posts preseason triple-double against Mavericks
Houston Rockets center Alperen Sengun tallied 16 points, 10 rebounds and 10 assists in 22 minutes against the Dallas Mavericks.
Anthony Vaccarello Exits Saint Laurent After a Decade
The designer leaned into the glamour and sex appeal of the storied Parisian fashion house. Sales nearly tripled during his tenure before sliding in recent years.
Angels Infielder Selects Free Agency After Year At Triple-A
Los Angeles Angeles infielder Jeimer Candelario was a Perry MInasian signing that didn't work out, so he's moving on.
Every Big Official Announcement at the Triple-i Gaming Showcase
Indie games take the spotlight at the second Triple-i showcase of the year
Today’s Papers – Triple Italy challenge, Roma lead Endrick race
La Gazzetta dello SportLet’s not stop anymoreWin (and confirm ourselves) to look for the quarter-finals. Mancini with Scamacca: ‘Let’s end well.’The last conflictBuonfiglio case: His son works...
How gaming store owners turned hobbies into businesses
Explore how local owners Mike Butkus and Tony Vandenberg turned a passion for gaming into successful businesses in the Upper Valley.
What was Austin Wells thinking on costly Yankees baserunning play?
In a measured tone, Austin Wells talked about his decision to stretch a double into a triple in ALDS Game 1.
Bishop’s computer science chair says AI is eliminating ‘grunt work’ and reshaping digital jobs
Dr. Russell Butler, chair of Bishop’s University’s Department of Computer Science, says artificial intelligence is increasingly taking over routine digital “grunt work,” changing the skills students and workers may need in the years ahead. Photo courtesy of Bishop’s University. Click here to read our platform! Get local news like this every morning. Subscribe free below. Subscribe Pulse Newsroom Artificial intelligence is already taking over some of the routine digital work once performed by entry-level employees, according to Bishop’s University Computer Science chair Dr. Russell Butler — a shift he believes will make expertise, judgement and the ability to evaluate AI-generated work increasingly important. Butler described the change as automation reaching what he calls the “bottom of the cognitive pyramid” during an interview with The Pulse about AI, university education and the future of digital work. His argument is not that humans are disappearing from the workplace. Instead, he sees their role changing as AI becomes capable of handling more of the repetitive tasks involved in computer-based work. “Everything’s converging on just AI basically doing all the grunt work,” Butler said. The bottom of the cognitive pyramid Butler is from Lennoxville, completed his undergraduate studies at Bishop’s and later earned his PhD at the Université de Sherbrooke. He joined Bishop’s in 2019 and now chairs its Department of Computer Science. He uses AI in research, teaching and other creative work, and said the technology is increasingly capable of handling routine digital tasks that once required substantial human time. “You’ve got the grunt work, like moving things around in Excel, doing basic programming tasks,” Butler said. “That’s like the bottom grunt work that the entry-level worker would have done two or three years ago.” Butler went further, saying in his view that much of this type of work has already been absorbed by AI tools. He connected that change to a shift he sees taking place in computer science, where entry-level roles have declined while experienced workers can use AI to increase what they can produce. “A senior developer now has access to essentially an unlimited amount of junior developers on demand,” Butler said. He was describing AI systems metaphorically, not literal employees. His point was that one experienced developer can now ask AI tools to produce code or other technical work that might previously have been assigned to more junior workers. That raises a broader question for universities and employers. If some of the simpler work traditionally given to newcomers can now be done by machines, how do people gain the experience needed to become senior workers themselves? Students doing work that once required years of programming Butler said he is already seeing the change inside his classroom. He created a Bishop’s course called CS208, Coding in Plain English, to show students — including those without traditional programming backgrounds — what they can accomplish using AI. Some come from disciplines such as psychology or neuroscience with no previous programming experience. “What I’m finding is that students who have zero programming experience, they come in from another discipline like psychology or neuroscience or something, they are now able to get up and running with real data sets,” Butler said. Butler’s own doctoral work involved neuroimaging, and he said he has assigned students work he considers comparable to the kinds of analysis he performed during his PhD. He described giving students a real dataset, an expected result and instructions to use AI to complete the analysis. Butler said those students have been able to carry out work at a level he associates with tasks he once performed after years of programming experience. That does not mean a student using AI instantly acquires the same knowledge as an experienced computer scientist. But Butler sees it as evidence that AI can dramatically lower the technical barrier between having a problem to solve and producing a working result. The role of the person using the system then changes. They need to know what to ask for, understand enough about the subject to judge the answer and take responsibility for what is ultimately produced. What about AI hallucinations? One persistent concern surrounding generative AI is hallucination — when a system produces information that sounds convincing but is false or unsupported. Butler said that problem has improved substantially in newer systems and is not as severe as it was with earlier models. He pointed in particular to newer AI systems’ ability to search the web, consult scientific databases and return source links rather than simply generating a citation from their internal model. Butler nevertheless said users should verify what AI produces. “You should verify,” he said while discussing citations generated with AI. His position is that hallucinations have become less common in the systems he uses, not that incorrect AI output is impossible. Human checking remains part of the process. Hours of work compressed Butler offered another example from his administrative work at Bishop’s. The university has been comparing CEGEP courses with first-year Bishop’s courses to determine where students may qualify for advanced standing. Traditionally, Butler said, that means reviewing two sets of course descriptions and manually matching one institution’s courses with another’s. As department chair, that could require hours of reading and comparison. He said AI can now be given both sets of material and asked to generate an initial mapping automatically. “It saves me hours and hours of work,” Butler said. Butler said the AI-generated mapping can also produce a better result than he would produce himself. He sees similar opportunities in businesses. A company may receive specifications, drawings, emails or other digital material from customers and then have employees convert that information into an internal format before anything can be manufactured or delivered. AI can increasingly perform parts of that intermediate processing. In Butler’s view, the employee does not necessarily disappear. Instead, the job becomes more about checking the result. “The human is still there,” he said. Judgement could become more valuable That change is central to Butler’s view of where digital work may be headed. If AI can produce a first draft, write basic code, compare documents or process large amounts of information, he argues that knowledge and judgement become increasingly important. “The real scarce resource going forward is going to be domain knowledge, expertise, and… credentials, authority, the ability to work with other people,” Butler said. He is therefore encouraging students not only to learn AI tools but also to broaden their education. He mentioned acting, fine art and photography as examples of courses that can help develop what he described as taste and intuition — the ability to recognize what is good, what is not and what should be changed. “And that’s the skill that they need now because the grunt work has been automated and now it’s about evaluating what the AI produces and telling it how to improve or expand the output,” Butler said. That does not remove the need for technical knowledge. Butler’s argument is that the emphasis may shift away from manually completing every step of a task and toward directing, checking and improving work produced with AI assistance. He also stressed that humans remain responsible for final decisions. “At the end of the day, the human has to make the final call,” Butler said, pointing to the question of accountability. Physical work may be different Butler draws a distinction between digital work and jobs requiring people to manipulate the physical world. He expects AI to continue advancing quickly in tasks performed almost entirely on computers. He is more cautious about claims that humanoid robots will soon be able to replace workers such as plumbers or electricians. Butler said those trades would not be replaced “anytime soon” in his view and described some current robotics demonstrations as overhyped. He described the situation as counterintuitive. “It’s almost like we solved the highest level first,” he said, contrasting advances in digital AI with the harder problem of building robots capable of operating reliably in the physical world. Butler’s argument is that some digital occupations could face automation sooner than trades requiring complex physical work. The wider AI shift in the Townships Butler’s comments come as local institutions are increasingly grappling with how AI should be used. The federal government recently announced up to $162 million over five years for 10,000 AI-related placements through Mitacs. The Université de Sherbrooke told The Pulse that the number of its collaborative research and innovation projects supported through Mitacs has approximately doubled since 2018-19, while the number of placements has approximately tripled. UdeS also said it already has projects involving both AI adoption and the application of AI to other fields. At Bishop’s, Butler said part of his role involves building the Computer Science department’s local presence, connecting students with regional partners and strengthening relationships with the Sherbrooke technology ecosystem. Those developments put universities in a difficult position. They have to prepare students to use the tools employers increasingly have available while also making sure graduates understand enough to recognize when those tools are wrong, incomplete or being applied to the wrong problem. The risk of losing human skills Butler does not see AI as risk-free. Later in the interview, he raised a separate concern: as AI becomes better at reading, writing, programming and other cognitive tasks, people could lose some of the underlying skills that historically helped produce new ideas. “The other danger is that we’re going to lose the human skills,” Butler said. He specifically mentioned reading and writing and argued that people could lose some of the lower-level understanding that contributes to breakthroughs. Butler said AI systems are based on existing human knowledge and argued that they become much more powerful when paired with a capable person. That tension runs through his view of the technology. AI can remove hours of routine work. It can allow beginners to perform tasks that once required substantial technical training. It can give experienced workers significant leverage. But the more capable the technology becomes, the more important it may be for people to develop the judgement needed to decide what should be done in the first place. For Butler, that is where education may have to change. Students still need to understand their field. They still need to know when something is wrong. And they still need to be able to make the final decision. But if AI increasingly handles the bottom of the cognitive pyramid, the value of a worker may depend less on how quickly they can perform the grunt work and more on whether they understand what the work is supposed to accomplish. Don’t miss the next story that affects your community. Join thousands of readers getting The Pulse every morning—plus breaking news alerts when it matters most. If you value this kind of local journalism, consider supporting it. Subscribe, share and like! Subscribe Share
Warhorse COO wants GTA 6 to set a new $80 price standard for triple-A games
Warhorse’s Martin Klima hopes GTA 6’s $80 price point sets a precedent for triple-A games…
Demon Star and Witch's Head kick off spooky space season
NASA highlighted a triple-binary system and an eerie nebula.
New “plant armor” more than triples strawberry yields
A new protective fabric boosted strawberry yields by as much as 3.56 times while blocking insects and still allowing sunlight, rain, and airflow to reach the plants. Originally inspired by research on military clothing, Plant Armor could also help farms reduce pesticide and water use.
Gerrymandering came for Kissimmee. So we hit the road to talk to voters
A new congressional map tripled the district’s size. So we decided to visit its constituents, both old and new, to understand what it means for voters.
Andy Burnham pledges pension triple lock changes to fund care reforms
The PM was at times emotional during his conference speech in which he outlined his long-term plan for the UK.
Triple lock move is significant, but it's a gamble
I had expected him to try to forge a political consensus on this thorny issue at this stage, but he has gone further than that.
Heart of a Fighter: A Colonel’s Journey from Silent Heart Attack to Triple Bypass at Broward Health
Dr. Alexander Justicz, Tim Irvin, Dr. Kenneth Herskowitz September 29, 2026- Tim Irvin II, a colonel with the Broward Sheriff’s Office (BSO), doesn’t back down from a challenge, even when it’s literally his heart on the line. Over the course of his more than 30-year career in law enforcement, the 51-year-old husband and father moved […]
Buckeyes Jeremiah Smith's Triple Crown Within Reach Saturday Against Iowa
Jeremiah Smith's quest for the Ohio State All-Time Triple Crown might come to an end against Iowa
Dodgers' Triple-A Franchise Win First Title
The Los Angeles Dodgers' Triple-A affiliate, the Oklahoma City Comets, take home the Pacific Coast League title.
From finance to science, Burke brings experience to Putnam County
Dear Editor, With so many struggling with the triple whammy of high taxes, high food prices and high energy costs, it is good news indeed that a triple threat candidate – a...
Homewood BBQ spot improves as 5 other eateries fall below health standards
Five Jefferson County food establishments, American Deli, Jimmy Johns, Walmart Deli, Triple S Food Store and Dollar General, scored below 85 in health inspections, while Jim N' Nicks in Homewood cleared reinspection with a 97 after months out of compliance, according to JCDH.
Woman kidnapped at gunpoint outside Roseville business, held for hours, police say
Twilio (TWLO) Keeps Climbing as Investors Rediscover its AI Business
Twilio Inc. (NYSE:TWLO) rose another 3.1% on September 24 to close at $299.66. The run has come alongside a series of analyst upgrades. TD Cowen lifted its target to $300 from $260, and Rosenblatt, Wells Fargo and UBS all raised theirs in the same stretch. The stock has roughly tripled from its low of $98.44 […]
Jessica Shepard secures another triple-double and Wings beat Storm 103-91
Dallas (27-16), which won just 10 games last season, set a WNBA record for the best single-season turnaround in league history with a 17-win improvement.
This Yankees’ Prospect Could Be X Factor in October Bullpen
Yankees right-handed pitching prospect and their third-best prospect, Carlos Lagrange, is being considered for possible addition to the postseason roster, reported Yankees beat writer Bryan Hoch of MLB.com in a tweet, per Aaron Boone.Lagrange has been recovering from a right shoulder capsular sprain that has kept him out since July. Lagrange returned to Triple-A Scranton […] The post This Yankees’ Prospect Could Be X Factor in October Bullpen appeared first on HEAVY.
Xiaomi 18 Pro and 18 Pro Max arrive with latest Snapdragon chips, privacy displays and more useful rear screens
They also get larger batteries and identical triple cameras. It only took a couple of hours for the first phones with Qualcomm’s new Snapdragon 8 Elite Gen...
Cincinnati Reds Recall Reliever for Season's Final Road Trip
The Reds recalled Connor Phillips from Triple-A and placed Tony Santillan on the injured list on Tuesday.
Jessica Shepard's breakout season with the Dallas Wings doesn't surprise her
Shepard is a first-time All-Star and sudden triple-double machine, tied with career WNBA leader Alyssa Thomas of Phoenix for the most this season with five while helping the Wings reach the playoffs.
Planetary crisis heightens global inequality of health opportunities
The worldwide inequality of health opportunities is being further heightened by the triple planetary crisis - climate change, loss of biodiversity and environmental pollution.
Planetary crises deepen global health inequality, paper warns
The global inequality in health opportunities is being further heightened by the triple planetary crisis—climate change, biodiversity loss and environmental pollution. Addressing it is more than a question ...
Lily Rabe Tells Chris Messina What It's Like to Return to the Stage After a Decade Away
After 10 years on screen, Lily Rabe returns to the stage with a triple-header that concludes with Other Desert Cities.
7 things to watch in MLB's final week include red-hot NL wild-card race, a Triple Crown chase and a historically bad division
Proposed rate hikes for long-term care plans would double premiums for thousands of seniors
Thousands of Maryland seniors paying for long-term health care could see their annual premiums double, or triple, over the next five years if state officials approve the steep increases requested by four Maryland insurance companies last week.
Whether you like it or not, celebrities have an impact on politics
The global groundswell of support for Macklemore’s pro-Palestinian advocacy serves to remind us that maybe celebrity activism really is that deep after all, writes Cheek’s Varsha Yajman. Subscribe In the last week, publications, podcasts, and influencers that have either rarely or never spoken about Israel’s genocide in Palestine have flooded my social feed. And it was all because singer Ed Sheeran and his team dropped Macklemore as his opener for saying “Free Palestine” on stage. Millions raised, millions speaking up in support of Palestine - all of this confirming my view that, whether I like it or not, celebrities do have an impact on political outcomes. And this is interesting when much of the time celebrity activism can induce an eye roll - I love to see Charli XCX pointing out a Palestinian flag in the crowd, but it’s hardly the bold symbol of allyship that some fans would make it out to be. But there’s a line between healthy scepticism and outright dismissal - and I’d argue that the latter lets the rich and powerful off far too easily. For instance, actress Jennifer Lawrence, once outspoken about her political views, last year told The Times she no longer believes celebrities have a role to play: “Celebrities do not make a difference whatsoever on who people vote for. So then what am I doing? I’m just sharing my opinion on something that’s going to add fuel to a fire that’s ripping the country apart.” While it’s a narrative she might find comfort in, it simply is not true. Grassroots movements often garner worldwide attention when celebrities and other high-profile spokespeople bring a mainstream platform to their causes. And this frustrates me. We have had three years of a live-streamed genocide. Macklemore himself has been calling for a Free Palestine long before he booked the Sheeran concert. Yet it’s the high-profile fallout of the last week that finally seems to have made saying “Free Palestine” socially acceptable in the mainstream. It feels like the collective mood has shifted, where calling out censorship is now the obvious response - not just the business of ‘radical’ activists. To recap, Sheeran’s decision followed an ultimatum from billionaire Robert Kraft, owner of Gillette Stadium, one of the venues Sheeran was scheduled to perform at: either drop Macklemore as your opener after only two of the eight scheduled shows, or you do not play at any stadiums. Sheeran’s disappointing decision to stand on the side of billionaire-led censorship has ultimately seen a surge in support for Free Palestine. It began when all his openers and his backing band pulled out of Sheeran’s tour, in solidarity with Macklemore and with the Palestinian cause. It was met with an uproar of support from those who had never or barely touched politics before: influencers lip-syncing to Macklemore’s music, singers like Jack Antonoff singing “Free Palestine,” and publications and podcasts standing with Macklemore. And finally, we saw material support: Macklemore donated $1 million in profits from his two nights opening for Sheeran’s tour to several Palestinian aid groups and called for Sheeran and Kraft to match it, which they have since promised to do. We’ve also seen children’s entertainer Ms Rachel follow suit with a $1 million donation to Palestinian aid, and publication PopBase has donated $10,000. Anera, a humanitarian aid group working in Palestine, Lebanon, and Jordan, said donations since Macklemore’s announcement were more than triple this month’s daily average. The group’s Instagram page has also gained 8,000 followers. Macklemore far from the first celebrity to speak and participate in politics in the Western World. In 1924, singer Al Jolson supported Republican candidate Warren G. Harding for president, and decades later, celebrities such as Harry Belafonte, Lena Horne, and Aretha Franklin voiced their public support for the Civil Rights movement. More recently, in the lead-up to the 2024 US election, ‘The Daily Show with Trevor Noah partnered with the organisation Power the Polls to recruit poll workers to address shortages- a problem disproportionately affecting voters of colour. The campaign saw 170,000 new sign-ups - 35,000 of which came directly through the TV show’s link - resulting in the recruitment of 713,000 total poll workers that year, an almost three-fold increase on the organisation’s goal. Alongside recruiting workers, celebrities in the US (where voting in elections is not compulsory) have made a huge difference by calling for people to register to vote. Taylor Swift’s endorsement of Kamala Harris in 2024 saw over 400,000 visitors on the voter registration site within 24 hours of her Instagram post. In 2023, Swift had urged her fans to register, resulting in 35,000 new voter registrations. Similarly, Ariana Grande promoted voter registration in 2019 by setting up booths at concerts on the American leg of her tour, resulting in over 33,000 voters registering. And the same thing is happening closer to home. This year, musician Jack River successfully called for government action to ensure creatives in Australia do not have their work scraped by generative AI companies. Celebrity as the mediator between the punter and the politician Celebrity activism isn’t just a feel-good news story - research tells us it actually makes a difference. By directing attention to issues affecting the average person, like voting inaccessibility or a lack of action on a genocide, researchers Alfred Archer and Amanda Cawston state that “celebrities can play a useful bridging role between political elites and the people they represent”. Alternatively, in a world where talking about politics is “not cool,” or where people lack exposure or knowledge to engage with politics, celebrities can act as an educational resource or an entry point into the political world - when they speak up about an issue, their audience gets exposed to it. Olivia Rodrigo’s Daisy Chain Fields festival is a perfect example. Rodrigo partnered with twelve organisations focused on women’s issues, such as reproductive rights. These organisations had stalls at the festival for people to meet them and were also featured heavily on social media, giving their issues global attention and raising $20 million for the organisations. We have also seen celebrities at award shows such as the Emmys wearing F*CK ICE pins, referring to the U.S. Immigration and Customs Enforcement’s treatment and detainment of people - generally people of colour. When celebrities speak up about political issues in public forums, they put the issue at the forefront of mainstream media, rally their supporters, and make it clear that, however much they disagree, the government cannot simply ignore it. Our over-reliance on celebrities versus our politicians As much as I love seeing my favourite celebrity use their platform for a good cause, there is an important question to ask: not whether celebrity activism is good or bad, but whether we should have to rely on celebrities. And the answer would, in an ideal world, be no. In an ideal world, or merely a just world, action on Palestine would’ve happened decades ago, climate change would be taken seriously, and most importantly, people would understand their democratic rights. However, that is not our reality. Only around 28 per cent of Australian Year 10 students reach proficiency in civics and citizenship. In the US, almost two-thirds of people under 30 say high school civics education didn’t prepare them to understand voting deadlines, how to research candidates, or how to vote by mail. When civics education is weak, our trust in these institutions and our understanding of change-making processes also decline. This is where celebrity steps in and becomes our main source of reliance. As Mary R. Connelly notes in _The Tartan, “_Celebrities will always be involved in campaigns in one form or another, but their presence is not what causes people to vote blindly. The lack of political engagement and literacy is what allows celebrities to wield their influence on the political sphere so impactfully.” About the author Varsha Yajman is the Digital Content Producer at Cheek Media. She is a youth advocate and lawyer with a background in climate litigation and is passionate about looking at the intersection between race, climate justice, and mental health. Thanks for reading Cheek Media Co. ! This post is public so feel free to share it. Share
Tre Tucker hits triple digits with TD
Las Vegas Raiders wide receiver Tre Tucker racked up five receptions for 119 yards and a touchdown on seven targets in Week 2
Dodgers Top Prospect Reaches Triple-A
Mike Sirota reached Triple-A for the first time on Saturday for the Los Angeles Dodgers.
Germany's IW institute triples growth forecast for 2026
By Maria Martinez BERLIN, Sept 20 (Reuters) - Germany's economy is set to grow by nearly 1.2% in 2026, helped by stronger exports and government spending in the first half,
Novant Health’s economic impact hits $4.33B as Cape Fear population surges
Novant Health’s Coastal Region now generates $4.33 billion in annual economic output, more than triple what it reported a decade ago, according to an updated independent analysis by University of North Carolina Wilmington economist Mouhcine Guettabi.
Novant Health’s economic impact hits $4.33B as Cape Fear population surges
Novant Health’s Coastal Region now generates $4.33 billion in annual economic output, more than triple what it reported a decade ago, according to an updated independent analysis by University of North Carolina Wilmington economist Mouhcine Guettabi.
A's Add Mason Barnett to Rotation for Stretch Run
After Barnett's struggles in the A's rotation last month he was optioned to Triple-A. In his most recent outing he tossed a gem — then a spot opened up in the rotation.
Why the Miami Heat Should Retire Jimmy Butler's Jersey
From dragging an eighth seed to the Finals to legendary triple-doubles, Jimmy Butler revitalized a directionless franchise and cemented a remarkable legacy among the Miami Heat's all-time greats.
Defense questions DNA evidence in TJ Wiggins triple-murder trial
Defense attorney Debra Tuomey questioned the reliability of DNA evidence linking TJ Wiggins to the 2020 killings at Lake Streety in Frostproof.
HAMAQ
HAMAQ will improve how scientists observe and forecast air quality in major metropolitan regions.
DICE owner Fever raises $250M led by EQT, at a $5.2B valuation, in ‘largest ever’ round for a
Fever says it has more than tripled its revenue over the past three years while remaining EBITDA-positive.
Phillies End Nationals' Win Streak In Final Meeting In 2026
The Washington Nationals fell in the final meeting and saw their five game win streak denied on Wednesday night, along with another Triple A demotion
🚨Confirmed: these will be Argentina's 3 friendlies
The Argentina National Team officially confirmed the schedule for a triple round of international friendlies on home soil. The side coached by Lionel Scaloni will play these matches from September 21 ...
Injustice 3 is seemingly the mysterious, unannounced fighting game that's been hosting playtests in California
It seems very likely this "triple-A fighting game" playtest is for Injustice 3.
Pixel 11 Pro Fold review: the foldable with the best triple camera
Big screen folder with slick software and advanced AI is just like a regular Android when closed
Prediction: ServiceNow's AI Business Triples Before 2029
Tripling works out to about 55% a year -- and the company's own target asks for even more.
Returning Red Sox pitcher will embrace ‘Swiss Army Knife’ role
Tanner Houck will pitch in two more rehab games for Triple-A Worcester on Tuesday and Saturday before potentially rejoining the Red Sox during the final week of the regular season.
I-5 closure begins: Drivers, businesses brace for impacts
Portland’s southbound I-5 Rose Quarter shutdown is underway for five weeks as ODOT begins concrete and rebar repairs. Early impacts were light, but backups hit I-84 and ODOT warns rush-hour trips could double or triple.
Diamondbacks 2, Texas 6: Return of the One Big Inning
At least Tim tawa got his first major league triple, and Pavin Smith had an RBI!
Washington Nationals Send Struggling Pitcher to Minor League
The Washington Nationals have sent reliever Clayton Beeter to Triple A Rochester after struggling through 2026
Triple B Media Adds SLVR Sports & Entertainment Featuring Los Angeles Kings Games to Its Portfolio of FAST Channels
/PRNewswire/ -- Triple B Media, a leader in the free, ad-supported television (FAST) universe, has announced a partnership with Silver Sports & Entertainment...
How Lower Manhattan transformed after 9/11
Over the years, its population more than tripled to 70,000.
Diamondbacks top prosect Demetrio Cristantes to play in fall league
Demetrio Crisantes will play for the Salt River Rafters this fall after reaching the Diamondbacks' Triple-A squad this season at 22 years old.
HOMETOWN HEALTH: Can too many hot drinks cause cancer?
Drinking scalding beverages is tied to nearly triple the risk of the most common form of esophageal cancer
Brewers' Contreras Reaches Major Home Run Milestone
The Milwaukee backstop powered a dominant offensive surge against Chicago, crushing a two-run blast to secure triple digits and cement his status as the roster's premier power threat.
Brewers’ Misiorowski Reaches Unprecedented Velocity Milestone
Jacob Misiorowski shattered records by surpassing 1,000 triple-digit pitches this season, cementing his status as a dominant rotation centerpiece for the Milwaukee Brewers.
Tigers prospect acquired in Tarik Skubal deal now starting Wednesday
Detroit Tigers prospect River Ryan, who was acquired in the deadline deal for Tarik Skubal, will start on Wednesday for Triple-A Toledo.
Cancer’s toll on 9/11 survivors is accelerating 25 years later
The number of victims receiving aid has tripled in recent years, a Post analysis finds, as the illness’s toll becomes more apparent.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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