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Gentle Brain Ultrasound May Help Ease Delusions in Schizophrenia
NYU Langone pilot study shows that transcranial ultrasound stimulation may safely treat delusions in schizophrenia and schizoaffective disorder. Learn more.
Free mental health fair connects Brevard community with resources
After his son's schizophrenia diagnosis transformed his family's life, Rev. John Baggett turned personal tragedy into advocacy.
New schizophrenia treatments, AI in mental health among topics at inaugural symposium in Roanoke
The two-day gathering on precision therapeutics will be held at the Fralin Biomedical Research Institute at VTC.
Stanford Grows Human Brain Tissue Inside Mice in Science Breakthrough
Stanford grew human brain tissue inside mice, creating living neural models that could transform drug testing for epilepsy, autism, and schizophrenia.
Mice with millions of human neurons in their brains bring scientists closer to understanding mental disorders
Researchers in the United States and Spain have created living rodents with cerebral cortexes from healthy people to facilitate research into autism, schizophrenia, and epilepsy
Scientists create mice with part-human brains
Researchers hope to shed light on conditions such as schizophrenia, epilepsy, cerebral palsy, intellectual disability and rare forms of dementia
Mental Health, Police, and The Death of Charles Adair
Charles Adair told jail officials he had schizophrenia. Less than 48 hours later, he was dead after officers restrained him in his cell.
Schizophrenia’s lost brain connections follow a surprising pattern
Specialized brain scans reveal that schizophrenia is linked to widespread loss of the synapses that connect brain cells, with the left side of the brain hit especially hard. The damage follows a surprisingly organized pattern tied to the brain’s chemistry and wiring. Researchers also identified a left frontal region that may serve as a starting point for the loss.
A broken mental health system has kept a Long Beach father locked up without a trial, his family says
Kaizann Guerrero's mother says he was doing well, with his schizophrenia under control, until he was sent to a state mental hospital following his arrest.
The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
AI mental health chatbots feel empathetic, but safety evidence still lags
Immune dysregulation may contribute to depression, schizophrenia, bipolar disorder, and anxiety through chronic inflammation, altered neuroimmune signaling, genetic susceptibility, and stress-related epigenetic changes. Evidence also suggests that biologically defined patient subgroups may benefit from more precise, immune-informed approaches to diagnosis and treatment.
Children of Holocaust survivors face higher schizophrenia risk, Israeli study finds
It’s known that the adult children of many Holocaust survivors suffer from trauma as a result of growing up with them and hearing about their horrific experiences, or when the parents refuse to share
Living with a cat: the mental health impact scientists are only now discovering - Futura-Sciences
A Surprising Connection Between Cats and Schizophrenia? An Australian study has revealed an unexpected link between cat ownership and the risk of developing schizophrenia. Researchers analyzed 17 studies conducted over 44 years, spanning 11 different countries. Their conclusion? Living with a cat could actually double your risk of developing schizophrenia-related...
More than a game: Football, friendship and mental health recovery
Men recovering from bipolar disorder, schizophrenia and other mental health challenges find help through football.
Science & Medicine: Relaxing excited neurons may lead to more effective treatments for schizophrenia
A new medication to treat schizophrenia has been developed by scientists who discovered that a neuron that inhibits the activity of other cells may be in short supply in those with the disorder.
Cat Ownership Linked to Increased Risk of Schizophrenia, Study Suggests
There's some kind of pattern.
WTAP + | Mental Health Mondays: What to Know about Schizophrenia
Our Andrew Noll sat down with Rachel Schieding of Westbrook Health Services to discuss Schizophrenia.
Breaking down schizophrenia stigma during Mental Health Awareness Month
As Mental Health Awareness Month enters its final week, one woman is using her experience with schizophrenia to help others and challenge common misconceptions about the illness.
While we argue, schizophrenia advances
Nature Mental Health - In this World View, Constanza Morén, a biomedical researcher and daughter of a man with schizophrenia, calls for humility and collaboration to bridge the divide between...
Faces of the cycle: Travra Zanders
Travra Zanders went from honors student to inmate as he struggled with mental health issues in his teenage years. Now 45, he’s trying to rebuild his life as a free man after years of coping with schizophrenia behind bars.
CARE Court should refocus on mentally ill homeless people, the hardest to help
California's mental health initiatives sometimes bypass individuals with schizophrenia or other psychotic disorders, often the most expensive to treat.
NC hospital uses music for mental health therapy, support: 'It's peaceful'
Many patients in the program are being treated for stress, schizophrenia, or bipolar disorder.
A gene mutation may trap the brain in the wrong reality in schizophrenia patients
A newly identified gene mutation may help explain why schizophrenia patients struggle to update their understanding of reality. The mutation disrupts a brain circuit involved in flexible decision-making, causing mice to stick with outdated choices even when conditions change. Researchers pinpointed the issue to a key thalamus–prefrontal cortex pathway. By reactivating this circuit, they were able to restore normal behavior—raising hope for future therapies.
RFK Jr. makes food sound like a miracle drug, but researchers say he often overstates the science
Robert F. Kennedy Jr. has claimed diet can "cure" schizophrenia and diabetes and allow people to rid themselves of bipolar disorder. Researchers say the comments overstate current evidence.
Health Rounds: Researchers find biomarker that could lead to improved schizophrenia treatments
Researchers have identified a biomarker linked to schizophrenia that could lead to new treatments to tackle symptoms of the debilitating mental disorder not addressed by current medicines.
RFK Jr. Touts Food as Medicine. He Often Overstates the Science, Experts Say.
The nation's health secretary recently claimed that diet can 'cure' schizophrenia and diabetes
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...
Can the Keto Diet Really Improve Mental Health?
Health Secretary Robert F. Kennedy Jr. recently said that the diet could “cure” schizophrenia. We asked experts about the claim.
Survey: Most Massachusetts residents unaware of cannabis mental health risks
A state survey of more than 11,000 Massachusetts residents found widespread misunderstanding about the mental health risks tied to regular marijuana use, including links to psychosis and schizophrenia.
Minerva Neurosciences Reports Fourth Quarter and Fiscal Year 2025 Financial Results and Business Updates
Initiation of confirmatory Phase 3 trial with roluperidone for negative symptoms of schizophrenia is planned for Q2 2026, with topline data anticipated in 2H 2027BURLINGTON, Mass., March 11, 2026 (GLOBE NEWSWIRE) -- Minerva Neurosciences, Inc. (Nasdaq: NERV), a clinical-stage biopharmaceutical company focused on the development of therapies to treat central nervous system (CNS) disorders, today provided business updates and reported financial results for the fourth quarter and year ended Decembe
No evidence behind RFK Jr’s claim keto diet can cure schizophrenia, experts say
Health secretary likely referred to Harvard psychiatrist who says he’s ‘never used the word cure in my work’
RFK Jr. says keto can 'cure' schizophrenia. Can a diet alleviate mental illness?
The health secretary claimed twice earlier this month that the high-fat, low-carb keto diet can "cure" mental illness. Experts say, "not so fast."
Science, serendipity and a new era for schizophrenia treatment
Drug treatments for schizophrenia have barely changed in 70 years, but a mix of chance and ingenuity offers fresh hope
RFK Jr. claimed that keto diets cured schizophrenia. Here’s what science says.
Ketogenic diets do show promise for schizophrenia and bipolar disorder, but the research is preliminary and not backed by randomized controlled trials.
RFK Jr. claimed that keto diets cured schizophrenia. Here’s what science says.
Ketogenic diets do show promise for schizophrenia and bipolar disorder, but the research is preliminary and not backed by randomized controlled trials.
Keto and Schizophrenia Researcher Says Kennedy Mischaracterized His Work
Dr. Christopher M. Palmer said in an interview that the keto diet, while promising, did not “cure” the mental disorder as the health secretary had claimed.
RFK, Jr. just claimed the keto diet can cure schizophrenia. Here’s what the science says
Preliminary studies suggest that a high-fat, low-carbohydrate diet could reduce schizophrenia symptoms in some people, but claiming it’s a cure is misleading, experts say
Bondi Junction stabbings: Doctor of killer referred to health regulators
A coroner has found Joel Cauchi's doctor failed to heed warnings he was having a relapse of schizophrenia.
A “dormant” brain protein turns out to be a powerful switch
Scientists at Johns Hopkins have uncovered a surprising new way to influence brain activity by targeting a long-mysterious class of proteins linked to anxiety, schizophrenia, and movement disorders. Once thought to be mostly inactive, these proteins—called GluDs—turn out to play an active role in how brain cells communicate and form connections.
Scientists found hidden synapse hotspots in the teen brain
Scientists have discovered that the adolescent brain does more than prune old connections. During the teen years, it actively builds dense new clusters of synapses in specific parts of neurons. These clusters emerge only in adolescence and may help shape higher-level thinking. When the process is disrupted, it could play a role in conditions like schizophrenia.
Mini brains reveal clear brain signals of schizophrenia and bipolar disorder
Tiny lab-grown brains are offering an unprecedented look at how schizophrenia and bipolar disorder disrupt neural activity. Researchers found distinct electrical firing patterns that could identify these conditions with high accuracy. The discovery opens the door to more precise diagnoses and personalized drug testing. Instead of guessing medications, doctors may one day see what works before treating the patient.
New details surrounding Nick Reiner's mental health history emerge
Los Angeles Magazine's Lauren Conlin discusses new details in the Reiner murder case as reports emerge of suspect Nick Reiner's schizophrenia diagnosis.