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JP Morgan maintains Sphere Entertainment at Overweight, lowers price target to $160 from $164
JP Morgan maintained Sphere Entertainment at Overweight and lowered its price target to $160 from $164, a 2.4% decrease.The price target implies an upside of 33.3% from the Nov 6 close of $120.02.Recent analyst actions on Sphere EntertainmentAcross the five most recent analyst notes published on Sp…
JP Morgan maintains Live Nation Entertainment at Overweight, lowers price target to $200 from $205
JP Morgan maintained Live Nation Entertainment at Overweight and lowered its price target to $200 from $205, a 2.4% decrease.The price target implies an upside of 14.1% from the Nov 6 close of $175.25.Recent analyst actions on Live Nation EntertainmentAcross the five most recent analyst notes publi…
Citigroup maintains AMC Entertainment Hldgs at Sell, raises price target to $2.60 from $2.20
Citigroup maintained AMC Entertainment Hldgs at Sell and raised its price target to $2.60 from $2.20, an 18.2% increase.The price target implies a downside of 17.2% from the Nov 6 close of $3.14.Explore more price target data and ratings for AMC Entertainment Hldgs on the Forecasts tab, and track a…
Wells Fargo maintains Live Nation Entertainment at Overweight, lowers price target to $221 from $222
Wells Fargo maintained Live Nation Entertainment at Overweight and lowered its price target to $221 from $222, a 0.5% decrease.The price target implies an upside of 21.9% from the Nov 5 close of $181.25.Recent analyst actions on Live Nation EntertainmentAcross the four most recent analyst notes pub…
Citizens maintains Inspired Entertainment at Market Outperform, lowers price target to $7 from $9
Citizens maintained Inspired Entertainment at Market Outperform and lowered its price target to $7 from $9, a 22.2% decrease.The price target implies an upside of 100.0% from the Nov 5 close of $3.50.Recent analyst actions on Inspired EntertainmentAcross the four most recent analyst notes published…
Wells Fargo maintains PENN Entertainment at Equal-Weight, raises price target to $23 from $22
Wells Fargo maintained PENN Entertainment at Equal-Weight and raised its price target to $23 from $22, a 4.5% increase.The price target implies an upside of 32.6% from the Nov 5 close of $17.34.Recent analyst actions on PENN EntertainmentAcross the five most recent analyst notes published on PENN E…
Jones Trading maintains Seaport Entertainment Gr at Buy, lowers price target to $30 from $36
Jones Trading maintained Seaport Entertainment Gr at Buy and lowered its price target to $30 from $36, a 16.7% decrease.The price target implies an upside of 39.7% from the Nov 5 close of $21.48.Explore more price target data and ratings for Seaport Entertainment Gr on the Forecasts tab, and track…
Macquarie maintains AMC Entertainment Hldgs at Neutral, raises price target to $4 from $3.50
Macquarie maintained AMC Entertainment Hldgs at Neutral and raised its price target to $4 from $3.50, a 14.3% increase.The price target implies an upside of 29.9% from the Nov 5 close of $3.08.Explore more price target data and ratings for AMC Entertainment Hldgs on the Forecasts tab, and track all…
Macquarie maintains Flutter Entertainment at Outperform, lowers price target to $120 from $128
Macquarie maintained Flutter Entertainment at Outperform and lowered its price target to $120 from $128, a 6.2% decrease.The price target implies an upside of 46.7% from the Nov 4 close of $81.79.Recent analyst actions on Flutter EntertainmentAcross the five most recent analyst notes published on F…
Bernstein maintains Flutter Entertainment at Market Perform, lowers price target to $100 from $110
Bernstein maintained Flutter Entertainment at Market Perform and lowered its price target to $100 from $110, a 9.1% decrease.The price target implies an upside of 14.1% from the Nov 2 close of $87.66.Recent analyst actions on Flutter EntertainmentAcross the five most recent analyst notes published…
Oppenheimer maintains Flutter Entertainment at Outperform, lowers price target to $110 from $120
Oppenheimer maintained Flutter Entertainment at Outperform and lowered its price target to $110 from $120, an 8.3% decrease.The price target implies an upside of 33.2% from the Oct 30 close of $82.59.Recent analyst actions on Flutter EntertainmentAcross the five most recent analyst notes published…
14 New Things Your iPhone Can Do in iOS 27.2
Apple released iOS 27.2 on October 26, bringing enhancements to Siri AI, adding Suggestions in Messages, and sneaking in a string of smaller additions across Photos, Podcasts, Games, Apple TV, and FaceTime. iOS 27.2 is available to download to your device now via Settings ➝ General ➝ Software Update. Note that some features may not be available in all regions or on all iPhone models. Apple maintains a feature availability list with all the details.
2026-2027 Audree V. Fowler Fellows in Protein Science
Graduate students Lenka Milojević (Zhou group), Akshaya Narayanasamy (Lindert group), Sarah Singleton (Conway group), and Janet Zhong (Feigon group) have been selected as 2026–27 Fowler Fellows and shared their research at a special event on Oct. 13, 2026. 2026-27 Fowler Fellows – Sarah Singleton, Lenka Milojević, Janet Zhong, and Akshaya Narayanasamy. Akshaya Narayanasamy and Prof. Steffen Lindert. Sarah Singleton and Prof. Stuart Conway. Janet Zhong and Prof. Juli Feigon. About the 2026-27 Audree Fowler Fellows in Protein Science Lenka Milojević is a fifth-year Biophysics Ph.D. candidate in the lab of Professor Z. Hong Zhou at UCLA. As an undergraduate at Maastricht University, she studied the structural basis of Mycobacterium tuberculosis virulence and amyloid-β fibril nucleation in the lab of Professor Peter Peters. She completed her bachelor’s thesis research at UCLA in the lab of Professor David Eisenberg, focusing on amyloid disaggregation, before beginning her doctoral studies. In the Zhou lab, Lenka uses cryo-electron tomography to visualize and characterize membrane-associated protein assemblies across a range of viral and cellular systems. Akshaya Narayanasamy is a fifth-year Ph.D. student in the Department of Chemistry and Biochemistry at UCLA, mentored by Professor Steffen Lindert. She earned her B.S.-M.S. in Chemistry from the Indian Institute of Science Education and Research, Thiruvananthapuram, where she worked in Professor Mahesh Hariharan’s lab investigating how single-atom substitutions influence crystal packing and charge transport behavior. She received her M.S. in Physical Chemistry from The Ohio State University before moving with the Lindert lab to UCLA. At UCLA, Akshaya develops integrative modeling methods that combine deep learning and Rosetta with experimental data, such as ion mobility mass spectrometry and cryo-EM, to improve protein structure prediction. Her current work focuses on developing an experimentally guided diffusion model and designing de novo protein binders with potential antibacterial activity. Ultimately, she aims to bridge AI-based structure prediction and experimental data to make computational protein models more reliable for drug discovery and therapeutic design. Sarah Singleton is a 4th year BMSB student, working in Professor Stuart Conway’s lab. She earned her B.S. in Biochemistry at Simmon University (Fenway, MA). Her research is centered on drugging the previously undruggable class of proteins—transcription factors. Zinc finger (ZF)-containing transcription factor proteins typically contain multiple ZF motifs, but little is known about the principles that govern the recognition of multi-ZF arrays by immunomodulatory imide drugs (IMiDs). In a multi-ZF array that contains several potentially targetable ZFs, which will be accessible and why? How does the surrounding protein architecture inform IMiD recognition? Sarah’s research aims to utilize her findings on the fundamental principles of ZF recognition to design IMiD therapeutics for transcription factors involved in health and disease. Janet Zhong is a fourth-year BMSB student, working in Professor Juli Feigon’s laboratory. She received her BSc and MRes from Imperial College London. At UCLA, Janet combines cryo-electron microscopy (cryo-EM) and biochemical approaches to investigate how proteins and RNAs assemble into ribonucleoprotein structures. Her research focuses on telomerase, the enzyme that maintains chromosome ends, with interests in its structure, assembly, and mechanisms. She has also worked on capturing the cryo-EM structure of a small bacterial non-coding RNA called raiA motif RNA. About Dr. Audree Fowler A strong supporter of the basic sciences and medicine at UCLA, alumna Dr. Audree Fowler (B.S. ’56 chemistry, Ph.D. ’63 biochemistry) established the Audree V. Fowler Fellows in Protein Science in 2008. Fowler was Director UCLA Protein Microsequencing Facility from 1984-1999 and is a Researcher Emeritus of the UCLA Department of Biological Chemistry. She is one of the first four women to receive a Ph.D. from the UCLA Department of Chemistry & Biochemistry. In 2018, the women were awarded the department’s 2018 Alumni Legacy Awards in recognition of their achievements in life, and generous support and service to UCLA. “The sciences gave me a great life. Now I want to help others have access to the same opportunities I enjoyed,” Fowler explained when she established the Fowler Fellowships endowment. Applications for the fellowships are solicited from graduate students in the Molecular Biology Interdepartmental (MBI) Ph.D. Program, Biological Chemistry, and Chemistry & Biochemistry Departments. In addition to presenting their research at a special seminar, the recipients each receive a $5,000 award. Previous Fowler Fellows from the UCLA Department of Chemistry & Biochemistry 2025-26 – Nikki Cheung (Clubb Group), Jonathan Jih (Zhou Group), Eileen Olivares (Loo Group), and Lily Taylor (Rodriguez Group) 2024-25 – Andrew Goring (Clubb lab), Eric Pang (S. Clarke and Rodriguez labs), and Miranda Villanueva (Backus lab) 2023-24 – Alexandra Turmon (Backus lab), Cindy Wang (S. Clarke and C. Clarke labs) 2022-23 – Cody Gillman (Gonen lab), Declan Evans (Houk lab), Troy Lowe (S. Clarke lab), Ashley Julio (Backus lab), and Alex Stevens (Hong Zhou lab) 2021-22 – Weixian Deng (Wohlschlegel/Plath labs), Yi Xiao “Sean” Jiang (Eisenberg lab), Maria Flores (Rodriguez lab), Carter Lantz (Loo lab), and Logan Richards (Rodriguez lab). 2020-21 – Janine Fu (Loo lab), Calina Glynn (Rodriguez lab), and Jiahui Lu (Eisenberg lab) 2019-20 – David Boyer (Eisenberg lab), Orlando Martinez (Clubb lab) and John Muroski (Loo lab) 2018-19 – Scott McConnell (Clubb lab), Kevin Murray (Eisenberg lab), Rebeccah Warmack (S. Clarke lab) 2017-18 – Michael Hughes (Eisenberg lab), Yuxi Liu (Yeates lab), Kanishk Jain (S. Clarke lab) 2016-17 – Brendan Amer (Clubb Lab) and Jeff Vinokur (Bowie Lab) 2015-16 – Henry Chan (Feigon lab), Smriti Sangwan (Eisenberg lab), Nicholas Woodall (Bowie lab) 2014-15 – Dan McNamara (Yeates lab) 2013-14 – Alex Jacobitz (Clubb lab), Alexander Patananan (S. Clarke lab), Carly Ferguson (Loo lab) 2012-13 – Letian Xie (C. Clarke lab), Anni Zhao (Eisenberg lab) 2011-12 – Timothy Anderson (Clubb lab), Soohong Kim (Weiss lab) 2010-11 – Zeynep Durer (Reiser lab), Cecilia Zurita-Lopez (S. Clarke lab) 2009-10 – Luki Goldschmidt (Eisenberg lab), Kristofer Webb (S. Clarke lab), Sheng Yin (Loo lab) 2008-09 – Nathan Joh (Bowie lab), Neil King (Yeates lab) Photos courtesy of Helen Houldsworth, the Molecular Biology Institute.
Fed Delivers an October Surprise on Strategy, Not Politics
The FOMC maintains Fed Fund rate as Chair Kevin Warsh introduces strategy meetings.| Global Finance Magazine
Citizens maintains Starz Entertainment stock rating on content strength
Citizens maintains Starz Entertainment stock rating on content strength
Sphere Entertainment Jumps 6.4% After Guggenheim Maintains Buy
Sphere Entertainment Jumps 6.4% After Guggenheim Maintains Buy
Kelly Vlahakis-Hanks Keeps Science Green at ECOS
Chief Executive Kelly Vlahakis-Hanks maintains a keen focus on sustainable manufacturing at ECOS, the company her father founded 60 years ago, building upon his initial idea to create non-toxic alternatives for cleaning. Van Vlahakis, a chemist, founded the manufacturer of green cleaning products at a time when no one was paying attention to ingredients. “He […]
Your Weekly Michigan Political Brief
U.S. Senate Abdul El-Sayed more than tripled the fundraising haul of his Republican challenger, former U.S. Rep. Mike Rogers (R-White Lake), for Michigan’s open U.S. Senate seat. Online records show El-Sayed raised $30,659,157 in the reporting period from July 16 to Sept. 30, while Rogers brought in $9,662,538. Despite that, Rogers’ campaign maintains a nearly […]
Daldrop Opens for Business in Southern Oswego County
$10 Million Facility in the L. Michael Treadwell Oswego County Industrial Park marks the largest expansion outside of Germany in the company’s 73-year history By Stefan Yablonski [caption id=attachment_11076 align=alignright width=450] Daldrop SBB CEO Jens Daldrop addresses attendees at the 2025 groundbreaking for the project. Daldrop also chairs the advisory board of Germany-based Daldrop Group.[/caption] A new era of cleanroom technology is underway in Central New York. The Daldrop Group’s advanced manufacturing facility and U.S. headquarters is physically built within the L. Michael Treadwell Oswego County Industrial Park. This industrial park is located in the town of Schroeppel. It marks the largest expansion outside of Germany in the company’s 73-year history. Daldrop SBB is based in Neckartailfingen, Germany. It is a global supplier of cleanroom technology, primarily to the pharmaceutical industry. It designs and builds advanced cleanroom environments for the pharmaceutical, biotechnology and medical technology industries. It nvested $10 million in the new project. “We broke ground in 2025; we were under construction all winter. We just opened this spring, early spring,” said Benjamin Morrow, operations manager and control. The company consolidated sites in Salina and DeWitt into the industrial park in Schroeppel, Morrow added. “The next move here is to maximize every square inch of this facility and then we are already looking at the expansion. So, it is more capital investment on equipment — definitely higher-end automation in additional equipment so we can produce more components and then to support the ever-growing base in North America,” Morrow continued. “We are the headquarters for service, maintenance and spare parts. So as Daldrop has more and more installations, they need more and more service, maintenance and spare parts. So that will come out of this facility as well — it already is.” “As a global leader in GMP (global manufacturing support) pharmaceutical cleanrooms for decades, I am very proud to bring manufacturing jobs to Upstate New York,” said Mike Sullivan, president of Daldrop US operations. Key to choosing Southern Oswego County [caption id=attachment_11077 align=alignright width=450] Daldrop SBB at the L. Michael Treadwell Oswego County Industrial Park when the company announced the start of construction.[/caption] Sullivan said that the selection of the Schroeppel industrial park was mainly due to the help of Operation Oswego County and two people in the organization. “Prior to being purchased by Daldrop International from the Stuttgart region of Germany, Vince Bongio was a founding partner in SBB Inc. as well as our head of engineering. We based out of Syracuse due to Vince’s skills in HVAC and the manufacturing capabilities found in Syracuse,” said Sullivan. Bongio moved to Syracuse from California in the 1970s to work in Carrier’s Industrial Division of Large-Scale Petrochemical Refrigeration. Next, he advanced to General Electric’s TV Tube Plant where he got into cleanrooms ,leading to his role of head of engineering for Clestra Cleanrooms where he met Sullivan, their New England distributor. “Vince Bongio is a phenomenal engineer. Formerly of Carrier, he grew up in California and went to Cal Poly,” Sullivan explained. “Carrier hired him right out of college and he moved to Syracuse. He is the reason we are in Syracuse today. He is retiring this year. We are very proud and his legacy is having brought Daldrop to Syracuse.” In 2000, Sullivan, Bazinet, Bongio Inc (SBB) was formed with engineering and manufacturing, based in Syracuse, and sales and construction based in Massachusetts as it is today. “SBB Inc. started in Syracuse. I had a design–build contracting firm out of Massachusetts that was primarily doing all the new technologies coming out of MIT,” Sullivan said. “I started a manufacturing side. A big thing for cleanrooms is the HVAC. Most cleanroom suppliers are architecturally focused people. The strength in Syracuse is HVAC. So, SBB developed with me running sales and construction out of Massachusetts and manufacturing out of Syracuse.” “Daldrop wanted to have a relationship in the States and of those who approached us, they were the only ones who really understood HVAC. So, we were the right fit for them. We did a joint venture focused out of Massachusetts from 2012 to 2018 leveraging their technologies,” Sullivan explained. “The commitment was if we brought their product to the States, we would do that if they built it here. “The pieces that had to be in place to make the investment, they wanted to acquire us, we were great with that. If you looked at business recommendations the general guidance was to build in a low labor area — something like North Carolina — but Syracuse had a strong background in HVAC and we chose Syracuse and Oswego County to be our headquarters in the States. So, it is built off of history, technology and the existing supply chain — bringing jobs back to the area.” During the initial discussions with Daldrop about coming to the U.S., SBB agreed to sell under the conditions Daldrop would manufacture in the U.S. There are many areas that offer incentives and economic packages, but the strength of HVAC expertise and skilled manufacturing was a big part of the discussions for site selection. Coming home [caption id=attachment_11078 align=alignright width=451] Construction moves forward in March at the L. Michael Treadwell Oswego County Industrial Park.[/caption] The second key person to building in Oswego County is Ben Morrow, Sullivan added. “Ben has been working with Daldrop SBB for more than 12 years and has advanced to COO of manufacturing and engineering. Ben grew up in Phoenix, so building a factory for the Germany company in Phoenix is a strong success for both his community and the appreciation of Ben’s skills as a team leader,” Sullivan said. “I went to high school in Phoenix. So, this is like full circle for me. It’s a small world,” Morrow said. “I hadn’t been back to Phoenix since graduation. This is one of the properties that John Trimble of C&S, he is the former president of C&S, he just retired, suggested. He and I were very good personal friends. John was from Mexico and I was from Phoenix. We knew each other from high school. And the architect of this building, Ed Smart of smartDESIGN Architecture in Batavia — I went to high school with him. So, this was a project that’s full circle a coming home kind of thing. The three of us knew each other — kind of like it was meant to be. Very serendipitous.” Schroeppel was one option for Daldrop to consider; the original intent was just to get a warehouse to store some product, he added. The facility is Daldrop’s largest outside of their native country. Total payroll at the facility will be approximately $2.4 million once fully staffed. “Here is 32,000 square feet and we plan to expand and put in an additional 10,000 square feet,” Morrow said. “We have 17.5 acres. We can put at least three more facilities here, just on this property. The master plan submitted for the current building is the first of possible three buildings on the campus.” “If we can find the right people and advance the production according to the plan, we should be able to grow for the next decade. One of the first jobs we filled was our new HR manager, with a primary focus posting and filling new positions,” Sullivan said. Stop the exodus, start hiring [caption id=attachment_11080 align=alignright width=452] Principals at the local Daldrop SBB headquarters, from left: Ben Morrow, Mike Sullivan and Jens Daldrop.[/caption] “I have been coming to Syracuse for 30 years. One of the things I had a hard time watching was the exodus of factories. One of the toughest things is to watch it with my partners’ kids who had to move away for jobs. It is important for us to give opportunity where people’s kids don’t have to leave the area to get work,” Sullivan said. “My responsibility is to find people who have skill sets that want to work and then I have to build opportunity for that work to happen. “After years of watching companies and Vince’s three sons all move out of the areas to get jobs, it is important to us to provide opportunities for the Syracuse region and help grow our company. We have been hiring for our new factory and will continue for the next few years.” “We are hiring and will continue to hire. Currently we have about 19 on staff right now,” Morrow said. “We expect to grow that by about 10 to 15 in the next 12 to 18 months or so. We are at 19 currently — one in the wings. It’s been great being able to hire locally. All these folks that we’ve been hiring, they all live within a few miles from here.” “We hired someone this past week (end of August). She grew up in the area, raised a family and is working down in Florida. She just took a job with us so she can move back and be with her family. We will be moving her back and she should be starting in October. We are very happy to see this happen,” Sullivan said. “I feel strongly about having a spot for the kids to not have to move out of the area. It is better to have people moving into the area.” Currently, Daldrop SBB has openings for finance manager, COO of construction and delivery, as well as mechanical, electrical designers and Revit modelers, construction managers, commissioning agents and many other skills that are needed. Along with Daldrop’s reputation in life science cleanrooms, there is a strong history in semiconductor, electronics, glass, photonics, aerospace and other markets. This may be helpful with any new technologies building in the market such as the Micron expansion and the support network, Sullivan said. “We acquired this property and closed on it two months before any announcement from Micron. It is serendipitous that they’re right down the street from us,” Morrow added. “Everybody started thinking ‘you guys are supporting Micron.’ We were here first. That is not a goal of ours. We may or may not … they are talking to us; it is an opportunity.” The long run [caption id=attachment_11079 align=alignright width=450] Benjamin Morrow, operations manager and control at Daldlrop, speaks during a recent ribbon-cutting event in Schroeppel.[/caption] “Long term, we will expand the Phoenix facility,” Sullivan said. “We built our facility with a campus approach. Sustainability is big. We designed our rooms to be more sustainable. Our building has no gas lines for heat. We put geothermal wells in the ground. We put heat pumps in for heating and cooling out of those wells and we put a large layer of solar panels up on the roof. We worked with National Grid for metering. Our building is a high efficiency model. We upgraded all the instillation and the glass filtering. So, it is a very green building. We will have a very minimal carbon footprint. It also adheres to LEED (Leadership in Energy and Environmental Design) construction standards.” “We are a bunch of HVAC engineers. We did a large scale geothermal and spent the money up front because we knew it made sense in the business sense in the environmental sense and sustainability,” Morrow said. “We have insulated metal panels on walls and roof; we are an envelope from the exterior.” Daldrop, as a global player, has a strong culture of sustainability that is found in all its products including the new facility. The building has been designed with (sixteen) 400-foot deep geothermal wells, high efficiency construction methods, approximately 70 kilowatt solar photovoltaic panels, electric vehicle chargers and 26% recycled content. “Daldrop thinks of long-term investing,” Sullivan said. “On the roof, photovoltaic panels supplement our power. Over half the energy that I use is coming from the sun. We have chargers up front for employee electric vehicles. This place is built to last. This slab that we are walking on, normal buildings are four inches, some go to six inches, we are nine inches all the way through — except where the heavy equipment is — that is 10 to 12 inches thick, solid concrete. It allows us to reconfigure for whatever type of equipment we want to bring in,” Morrow said. “We are authorized by Underwriters Laboratory to self-certify so we don’t need to have an inspector come out and recertify. We get audited often, but we certify our own electronics. The control system in this building is rather high-end. Our thermostat in every room is zoned, independent. We analyze the data; incorporate it with our solar panels.” “There is a lot of competition for people to work. It’s not just about how much salary they are going to make — it’s about the work environment, the ability for stability. We want to make sure our employees have the best environment to work in,” Morrow added. Similarities “One of the reasons I believe why Daldrop chose this area, Phoenix in particular, is because it is a village, a river-based village. Neckartailfingen in Germany where Daldrop is based is also a river-based village, manufacturing community. So, there is a lot of similarities — that smalltown feel,” Morrow said. “We have a lot of connections through multiple employees that lead back to Carrier, also. Everything came together, the timing everything.” “We are thankful for all the economic development support. Everyone has been helping make this happen. So, keep it up, it is working, that is all I got to say, Sullivan said. “If you look at historical industrial manufacturing, this region has skills that have been un-utilized. The northern industrial region has a lot of skills that if we can tap before they go away, we can leverage them. That is what we are trying to do. You’d be surprised at the supply chain left behind from Carrier — that supply chain is still there.” “Operation Oswego County has been fantastic,” Morrow added. “I can’t say enough good things about that group.” What Is Cleanroom Technology Cleanroom technology is a system of specialized engineering, filtration and operational controls used to maintain an extremely low concentration of airborne particles, microbes and chemical vapors. How It Works • Air Filtration: Uses HEPA or ULPA filters to remove 99.97% of tiny particles down to 0.3 microns. • Airflow Control: Directs air in a steady, unidirectional (laminar) or filtered turbulent pattern to push dust away from work areas. • Environmental Regulation: Maintains precise control over temperature, humidity and positive air pressure to block outside air leaks. • Specialized Attire: Requires personnel to wear full-body garments (“bunny suits”), gloves and masks to stop human shedding
Epic used AI to find potential security flaws that could expose patient health records
Epic Systems revealed last month that it used an advanced artificial intelligence tool to find security weaknesses that could have allowed undetectable access to patient health data. Epic maintains health records for more than 325 million patients around the world.
StoneX maintains Buy rating on Sphere Entertainment, $125 price target
StoneX maintained their Buy rating on Sphere Entertainment's stock with a price target of $125.00.The price target implies an upside of 12.8% from the Oct 5 close of $110.80.Key takeaways from the analyst noteLong-Term Growth Potential: Despite recent challenges, Sphere Entertainment is expected to…
BTIG maintains Buy rating on Sphere Entertainment, $160 price target
BTIG maintained their Buy rating on Sphere Entertainment's stock with a price target of $160.00.The price target implies an upside of 44.4% from the Oct 5 close of $110.80.Key takeaways from the analyst notePositive Long-Term Growth Potential: Sphere Entertainment is positioned uniquely in the grow…
Mars’ North Polar Ice Is Much Cleaner Than Scientists Thought
Beneath the dusty surface of Mars’ north pole, scientists have uncovered surprisingly clean layers of ice that may preserve a hidden record of the planet’s dramatic climate history. Earth maintains a relatively steady posture in space thanks to the gravitational anchor of a massive moon. Mars lacks that stability. Tugged only by two tiny moons,
Trump administration uses taxpayer money to air 2024 Trump campaign ad
A television advertisement from Donald Trump's 2024 presidential campaign is the latest in a series of ads promoting the president ahead of the midterms that the White House maintains are “public service announcements.”
Trump administration begins airing 2024 Trump campaign ad
WASHINGTON (AP) — The Trump administration is using taxpayer funds to air a television advertisement from Donald Trump’s 2024 presidential campaign in the latest in a series of ads promoting the president ahead of the midterms that the White House maintains are “public service announcements.” The 30-second video, which is virtually identical to one that […]
Trump administration begins airing 2024 Trump campaign ad in latest taxpayer-funded messaging
The Trump administration is using taxpayer funds to air a television advertisement from Donald Trump’s 2024 presidential campaign in the latest in a series of ads promoting the president ahead of the midterms that the White House maintains are “public service announcements.” | 830 WCCO
Trump administration begins airing 2024 Trump campaign ad in latest taxpayer-funded messaging
The Trump administration is using taxpayer funds to air a television advertisement from Donald Trump’s 2024 presidential campaign in the latest in a series of ads promoting the president ahead of the midterms that the White House maintains are “public service announcements.”.
Trump administration begins airing 2024 Trump campaign ad in latest taxpayer-funded messaging
The Trump administration is using taxpayer funds to air a television advertisement from Donald Trump’s 2024 presidential campaign in the latest in a series of ads promoting the president ahead of the midterms that the White House maintains are “public service announcements.”.
AEW's Brian Cage Defends PED Use
AEW star Brian Cage has acknowledged using performance-enhancing drugs, but maintains that it's quite possible to use them safely.
ProTributeBands.com Clarifies Direct Booking Model for Corporate Event Entertainment Planners
SAN RAMON, CA - September 25, 2026 - PRESSADVANTAGE -ProTributeBands.com, the curated booking and lead generation platform for high-end tribute bands, has outlined how its direct-booking structure works for event planners seeking corporate event entertainment. Under the model, bands featured on the platform negotiate terms and close each booking directly with the client, while ProTributeBands follows up to keep the transaction moving smoothly.The structure separates ProTributeBands.com from traditional booking agencies that insert themselves into every contract. Rather than acting as an intermediary that controls the final agreement, the platform connects event planners, performing arts centers, festivals, wedding clients, and private party hosts with pre-screened, national-act-caliber tribute acts, then steps back so the parties can settle details themselves. The platform maintains contact with both sides to ensure momentum is not lost during the process.Founded by David Victor, former guitarist and co-lead vocalist of the multiplatinum band BOSTON, ProTributeBands.com features tribute acts covering artists such as Queen, The Beatles, ABBA, Journey, The Eagles, and Pink Floyd. Selected bands receive optimized profile pages and booking leads generated through the platform."Event planners often assume a booking platform means another layer of negotiation and markup," said David Victor, Founder of ProTributeBands.com. "The approach here is different. The bands negotiate terms and close each booking directly, which keeps the conversation honest and the details accurate. The platform stays involved by following up so nothing stalls between the first inquiry and the signed agreement."The direct-booking method reflects how corporate and private event planning typically operates. Planners frequently need to confirm technical requirements, stage dimensions, scheduling, and performance specifics with the people who will actually be on stage. By allowing those conversations to happen between the client and the band, the model aims to reduce miscommunication that can occur when information passes through a third party.ProTributeBands.com applies a screening process before an act appears on the platform, focusing on production quality, musicianship, and readiness for larger venues. The company ranks tribute bands across categories including Queen, The Beatles, The Eagles, Journey, Pink Floyd, and BOSTON tributes, drawing on performance quality and audience response.The ProTributeBands guide to hiring a tribute band offers additional context for planners weighing these decisions, covering topics such as understanding the audience and event, assessing entertainment value, viewing an act in person before hiring, and reviewing rider and insurance requirements. The guide addresses the practical considerations planners face when selecting an act for a corporate function, festival, or private celebration."A tribute production for a corporate audience has to hold the room the same way a headline act would," Victor said. "The vetting exists so planners can trust that the act they see listed can deliver at that level, and the direct-booking structure lets them confirm every detail with the band before committing."ProTributeBands.com serves clients across the United States and abroad, working with tribute acts that perform at performing arts centers, summer concert series, product launches, corporate parties, private parties, and wedding receptions. The platform also accepts artist submissions from tribute bands seeking consideration for inclusion. The company operates online at protributebands.com.###For more information about ProTributeBands.com, contact the company here:ProTributeBands.comDavid Victor(925) 236-0217hello@protributebands.com11040 Bollinger Canyon Road Suite E-938, San Ramon, CA 94582
Flutter Entertainment stock maintains outperform rating at Citizens
Flutter Entertainment stock maintains outperform rating at Citizens
Tulare County keeps close eye on fiscal health - The Sun-Gazette Newspaper
Tulare County maintains conservative $2.26 billion budget while bracing for upcoming state, federal funding pressures
BWS Financial maintains Buy rating on Inspired Entertainment, $20 price target
BWS Financial maintained their Buy rating on Inspired Entertainment's stock with a price target of $20.00.The price target implies an upside of 299.2% from the Sep 15 close of $5.01.Key takeaways from the analyst noteStrong Revenue Generation from Leisure Segment: Inspired Entertainment derives the…
Charlie Crist PC banks another $50K as Ken Welch’s comes up with nothing
Welch's available cash is quickly dwindling even as Crist maintains nearly $383K.
PENN Entertainment holds steady with $18 target amid mixed earnings and debt concerns.
PENN Entertainment maintains a Hold rating with an $18 price target due to mixed Q2 earnings and limited valuation upside compared to peers. The retail segment showed solid growth with a 5.6% increase in adjusted EBITDAR, especially strong in the Midwest and West regions. However, the Interactive segment's revenue growth has slowed sharply despite improving profitability, raising concerns about long-term competitiveness. The company remains highly leveraged with net debt around 5.2x–5.5x, making proactive debt reduction and consistent Interactive profitability key factors to watch going forward.
House Speaker Mike Johnson says Trump’s $5,000 ‘dividend’ needs congressional approval
President Donald Trump's proposal to send $5,000 to every American adult if his Republican Party maintains control of the House and Senate in the November election needs congressional approval, House Speaker Mike Johnson said Sunday.
House Speaker Mike Johnson says Trump’s $5,000 ‘dividend’ needs congressional approval
WASHINGTON (AP) — President Donald Trump's proposal to send $5,000 to every American adult if his Republican Party maintains control of the House and Senate in
House Speaker Mike Johnson says Trump's $5,000 'dividend' needs congressional approval
House Speaker Mike Johnson says Congress would have to approve President Donald Trump's proposal to send $5,000 to each American adult if the Republican Party maintains control of the House
House Speaker Mike Johnson says Trump's $5,000 'dividend' needs congressional approval
House Speaker Mike Johnson says Congress would have to approve President Donald Trump's proposal to send $5,000 to each American adult if the Republican Party maintains control of the House and Senate in the November election.
Bone Health Without the Hype
I am at the Australasian Menopause Society meeting and we had a fantastic lecture on Bone Health on Day 2, called, “Everything you need to know about bones - except the boring bits!” Spoiler alert, there were no boring bits. The lecture was given by Dr. Amanda Beech, who is a senior staff specialist in Obstetric Medicine and Endocrinology at the Royal Hospital for Women, where she is director of the Bone Density Unit. I want to summarize my top 10 take-aways for you. Share Osteoporosis is a disease of low bone mass, disruption of bone microarchitecture, and fragility of the skeleton. It is a silent disease…until someone develops a fracture. The diagnosis of osteoporosis is based on either fragility/minimal trauma fractures or a T-score of less than -2.5 on a DXA (Dual-Energy X-ray Absorptiometry) or bone scan. It is important to recognize that about 50% of minimal trauma fractures occur when women have low bone mass (often referred to as osteopenia), but not osteoporosis. This tells us that bone strength is more complicated than a number on a DXA report. I am going to add a little here that wasn’t in the talk (one can only include so much in 25 minutes), as many women might read the above paragraph and think, “Shouldn’t we be treating everyone with low bone mass if this is when 50% of the fractures occur?” Many fractures happen for women with low bone mass because there are so many women with low bone mass –it is a statement about the population on a whole, not about the fracture risk of low bone mass. For you as an individual, bone density is only one component of fracture risk and many women with lower bone mass will not have a significantly elevated fracture risk. This is why individualized risk assessment matters. Subscribe We build bone in our teens and twenties, and by the time we are about thirty we have reached peak bone mass. This is why, when we discuss risk factors for osteoporosis, it is important to consider factors that might have affected us in our teens and twenties when we were actively building bone, such as nutritional restriction/energy imbalance. It is important to ask women about a history of eating disorders, and for those with such a history, getting a bone scan in perimenopause or at age 50 is likely warranted. (This image below isn’t from the talk, but is similar to one that was). Bone mass is relatively stable until about two years before the final menstrual period, and perimenopause marks a time of rapid bone loss for women. Using urinary markers of bone loss we know that the time of significantly accelerated bone loss starts about 1 year before the final period and ends about 2 years after the final period. The Study of Women’s Health Across the Nation (SWAN) shows that over the menopause transition women lose an average of 10.6% of the bone at their lumbar spine and 9.1% at the femoral neck While this wasn’t covered in the lecture, I want to add that the rapid bone loss during perimenopause is clearly related to more than estradiol, because during this time estradiol levels can be erratic and not uniformly low. Bone loss during perimenopause is likely a multi-hormone event. For example, rising FSH (follicle stimulating hormone) tracks with bone loss better than estradiol, and there is evidence that FSH may act directly on bone. While decreased estrogen matters, there is clearly more going on. FSH and bone is an active area of research. Subscribe Screening for osteoporosis was recommended fairly broadly before age 65, and was taken from the “Practitioner’s Toolkit for Managing Menopause,” from Monash University. Here is a screenshot from the toolkit that was used as a slide: I am going to add a little bit more about body weight here for clarification. Low body mass (typically 152.1 lb): 0 points (risk neutral) 60–69 kg (132.3–152.1 lb): 3 points (adds some risk)
Penn State Health maintains strong credit ratings from Moody’s and S&P Global Ratings
Penn State Health has received strong validation of its financial strength and strategic direction from two of the nation’s leading credit rating agencies.
USC Dornsife professor Moh El-Naggar named director at Carnegie
Biophysicist and microbiologist will lead Carnegie’s Biosphere Sciences and Engineering, maintains appointment and research at USC Dornsife
Players will come through if good enough
Celtic manager Martin O'Neill maintains young players will come through at clubs if they "are good enough". The Scottish FA are to offer clubs financial incentives to play youngsters while data analysts and Club Brugge recruitment director Guilian Preud'homme presented to those assembled.
Hinge Health Director Kristina Leslie Sells 1,200 Shares for $105,876
Leslie maintains a $2.6 million stake after the 4% reduction.
Executive Liquidates 2,900 Shares of Entertainment Stock, Valued at More Than $525,000
Capo's $534,000 liquidity event reduces his direct stake by 25%, leaving him with $1.6 million in remaining holdings as the stock maintains momentum.
The Academy of Natural Sciences is closing its museum after nearly two centuries
The closure does not affect the rest of the institution, which builds and maintains the collections and conducts research through departments such as the Patrick Center for Environmental Research.
Small Towns, Big Care: Three Rivers Hospital Tackles Rural Health Access on "All Access hosted by Andy Garcia"
Healthcare availability in isolated regions faces unprecedented operational strain as small facilities close nationwide. Filmed on location on August 13, 2026, a new feature from "All Access hosted by Andy Garcia" highlights how Three Rivers Hospital maintains comprehensive, 24/7 care across a remote service territory. The Public Television segment illustrates how a facility established by local residents decades ago continues to serve as an independent medical hub. Through continuous quality pr
SHK & Co. sees opportunities to develop alternatives business
Sun Hung Kai & Co.’s Group CFO Brendan McGraw discusses their latest earnings. He sees opportunities to develop their alternatives business. On AI, he noted that the group maintains around 20% exposure to the TMT sector and invests across the broader AI ecosystem rather than concentrating on any single area. He adds that exit conditions have improved and are expected to continue for the rest of 2026, supported by rising deal flow in North America amid a stable interest rate environment.
Mental health provider accused of sharing data with Meta, Google settles lawsuit for $3M
While LifeStance Health maintains it did not knowingly do anything wrong and is committed to the privacy of its patients, it has agreed to make sure that no third-party tracking technologies are running on its website.
Doctors argue their role in the age of AI
Humans must remain in the loop, the AMA maintains.
Sunflower Health Plan Maintains Strong Member Satisfaction Ratings in Annual LTSS Survey
Independent survey finds nearly 98% of respondents are satisfied with the care they receive from Sunflower and 99% report feeling safe with those who support them. LENEXA, Kan., Aug. 13, 2026...
Butterfly lilies wing their way to Science
Many animals and plants show left-right differences in how their bodies or organs are arranged, but we still know little about how such asymmetries evolve or how genes control them in natural populations. Mirror-image flowers, in which female and male sex organs are deflected to opposite sides in left- and right-handed forms, provide a notable example of such asymmetry. Here, we studied South African butterfly lilies, where individual plants produce only left- or right-handed flowers. Their mirror-image flowers promote outcrossing by depositing pollen from each floral form onto a specific region of a pollinator’s body that matches the stigma position of the opposite form. This suggests that selection for efficient pollen transfer between forms maintains this natural polymorphism. Our work uncovers a hemizygous supergene that coordinates the left-right orientation of female and male sex organs in mirror-image flowers by linking two independently acting genes for style and stamen handedness in a single, nonrecombining genomic segment. This architecture ensures the coinheritance of a matched pair of organ orientations that is essential for efficient cross-pollination between floral forms. At the developmental level, we show that floral handedness emerges from the interaction between an intrinsic tissue chirality and a gravitropic response that orients the style and median stamen relative to gravity. Together, these findings reveal how a supergene, hormone and microRNA signaling, tissue chirality, and an external physical cue combine to produce and maintain a stable left-right polymorphism in natural plant populations.
Where the Trump Administration's Global Health Agreements Stand
The State Department has now signed more than 30 bilateral global health cooperation agreements, adding dozens of new deals with partner governments since our initial update and rundown of outstanding questions in December. And as the administration works to reorient the geographic focus of US assistance, the sweeping new agreements have reached the Western Hemisphere and the Indo-Pacific. Beyond signing additional agreements, the State Department published the official texts of five memoranda of understanding (MOUs) in response to a FOIA request, only to quietly disappear from the government's website. (Public Citizen maintains separate copies—along with other MOU-related documents from unofficial sources.)
Netflix Sued For $105 Million After Hard Drive of Unreleased Nicolas Cage Movie Was Stolen From Its Office
The lawsuit faults Netflix for losing a drive that contained a copy of World War II thriller 'Fortitude.' The company maintains it's not responsible for the loss of the movie, which it says was delive...
Glencore Increases Copper Production and Maintains 2026 Guidance as Trading Business Performs Strongly
Glencore (LSE:GLEN) delivered a solid operational performance during the first half of 2026, with own-sourced copper production increasing 15% year over year to 397,000 tonnes. The improvement was driven by stronger mining rates and higher ore grades at its African Copper operations, together with improved grades at the Antamina mine in Peru.
Senate Weighs How to Measure Science Edge Over China
Senate committee investigates how the U.S. tracks scientific progress and maintains competitive edge against China. Discover implications for research funding.
Trump ousts election commission members in latest push to reshape U.S. voting
The White House on Friday confirmed the executive action against members of the Election Assistance Commission, which distributes federal grants to states, oversees the testing of voting systems and maintains the national voter registration form.
Charlton College of Business maintains AACSB accreditation, placing UMass Dartmouth among the world’s top business schools
Reaccreditation recognizes Charlton’s commitment to academic quality, faculty excellence, student success, and regional economic impact
What Does the Memorandum of Understanding Signed Between the US and Iran Mean?
Iran maintains that transit through the Strait of Hormuz should be under the control of both Oman and Iran with no international intervention.
Trump announces Republican midterm convention in Dallas in September
President Donald Trump has announced that Republicans will hold their first-ever national convention ahead of the midterm elections, an unusual event aimed at boosting turnout in races that will decide whether the party maintains control of Congress.
Trump announces midterm convention for Republicans in Dallas in September
The event is aimed at boosting turnout in races that will decide whether the party maintains control of Congress
After devastating fire, USF marine scientists race to keep ocean monitoring on track
A fire at the USF Marine Science Laboratory displaced the Ocean Circulation Lab, which maintains its buoy program.
We can create the future of science right now
Paul Litvak is the founder and Executive Director of the Robyn Dawes Institute and a Visiting Scholar at UC Berkeley. He has a PhD in Behavioral Decision Research from Carnegie Mellon where he studied emotions and the sunk cost bias. Over 15 years in industry, he solved a wide range of challenging technical problems. At Meta he created models optimizing the ad review process. At Google he ran experiments to measure social influence. At Airbnb, he was a product manager leading machine learning teams optimizing search ranking and price suggestions. He also co-founded and led product at Rhythmic Health, a venture-backed biosensing startup, creating an accurate low cost system using a color changing strip and a smart phone to measure salivary lactate. The bottleneck At this point, it is uncontroversial to say that science needs to stop using the PDF article as the unit of knowledge and currency. The unbearable slowness of scientific publishing, the profit motive and margins: I’m not saying anything new. The PDF also sucks because it’s hard to extract structured information, which makes it hard to do evidence synthesis. As a result, we do much less evidence synthesis than is needed. And evidence synthesis ultimately undergirds most policy and medical decision-making. I can see second-by-second real-time odds for any sporting or newsworthy event, but a school board can’t see the best evidence on whether their 8th graders should be taught algebra. As a society, we don’t treat this as an important problem. Again, not controversial. Not only is the problem well understood, but the solution has already been laid out. What we need is AI-assisted living evidence synthesis - (1) an open knowledge graph of atomic claims, (2) claims linked to evidence, (3) assessment and synthesis of each piece of evidence, and (4) continuous updating with new data. What few realize (yet) is that the technical capacity to build this vision for a significant portion of science already exists. Not only that, scientists and startup teams are already building many of these components. I know this because I’ve been surveying the space and talking to many of the builders. There are some missing pieces: for example, evaluations of how well some of the components work. But at this point, most of what’s missing is a fully end-to-end working integration of all of these parts. In the rest of this essay, I’m going to lay out all the parts of a working living evidence layer for science and who is working on them, and propose concrete next steps for building this system. What’s now possible The diagram above outlines the components of a living evidence synthesis platform, including some of the teams working on each component1. Scientific PDFs are processed into claims with associated evidence. The evidence is subjected to a forensic audit, methodological evaluation and robustness and reproducibility checks. Finally it’s given a weight in a continuously updating synthesis. What follows is a description and status of each component and a few of the teams working on them. Document understanding The first thing you need to be able to do is turn an article into structured data. Mostly that means parsing PDFs. There are often multicolumn layouts that confuse non-specialized PDF to text processing libraries. For scientific papers, there is the added complexity of parsing formulas and tables and figures. This is a really hot area - there are startups offering APIs, and it seems like a new open source package gets posted to Github every few weeks. What follows isn’t exhaustive. A package called GROBID was the state of the art for a while, they didn’t update their package for nearly two years until very recently. In the meantime reducto.ai released an AI powered PDF extraction API, PaddleOCR became popular, IBM released a model called Docling, and both Mistral and Gemini created models and libraries. I also know of at least one other well-funded psychology research group working on a paper parser. By contrast, there are few open evals in this space, with no extensive evals for complex table comprehension in particular. Nonetheless, I’m confident this will be a solved problem soon, given the combination of LLM advances and developer interest. Hypothesis level extraction There has been increasing interest in comprehending the extracted text of papers and linking information to evidence for each hypothesis. A lot of work has already been done. Trialstreamer (Marshall et al. 2020) and RobotReviewer LIVE (Marshall et al. 2023) demonstrated automated extraction of trial population, intervention, and outcome at scale on clinical RCTs. PaperQA2 (Skarlinski et al. 2024) and Ai2 ScholarQA (2024) extended this to retrieval-augmented question answering with citation grounding. Elicit, Consensus, and SciSpace operationalized claim-level extraction for end users. OpenEval (Booeshaghi et al. 2026) is the most recent and most ambitious: 1.96 million atomic claims extracted from 16,087 eLife manuscripts using Claude Sonnet 4.5, grouped into ~299,000 results, with LLM evaluations showing 81% agreement with human peer review on a 2,487-paper subset. None of these solutions link claims to test-statistics, as you would need to evaluate randomized controlled trials. This is why I built the evidence.guide API - to extract hypotheses and associated test statistics from behavioral science papers. The best public eval of this kind of extraction I’m aware of comes from the recent SCORE project - they had humans code thousands of psychology papers to extract their claims by hand. It would be extremely helpful to the world if all scientific PDFs were available as structured open data. I’ve been working to make this happen, both directly at Berkeley and through coordination with large entities I can’t yet speak of; as hard as it is to do, I think it’s possible2. Forensic audit A lot of work has been done on forensic audit, but some gaps remain. Of course, for biology papers that rely on images for evidence, there are a variety of tools (notably Proofig and ImageTwin) to spot anomalies. These are still well short of what sleuths like Elizabeth Bik can do on her own, but these tools are constant companions among fraud analysts. There’s someone working on auditing Excel files for anomalies, and a number of teams are automating numerical checks like GRIM and SPRITE, including Scrutiny project, the INSPECT-SR team as well as statcheck. The regcheck team is building a way to use AI to compare preregistrations to analyses in papers, to ensure there aren’t significant deviations. Nonetheless, there are many other kinds of anomalies to screen for, both public and less publicly known. And there are no formal evals for anomaly detection that I’m aware of. Still, there’s a lot to draw from in this space and I’m pretty certain we will be able to scan papers for most kinds of obvious anomalies in the near future. Methodological review This area has been white hot, though I fear for many of the startups in this space, because this capability may become commoditized. There are at least six different AI peer review companies, including Refine.ink, Reviewer3, ReviewerZero.ai, Q.E.D. Science, Paper Wizard, and Isitcredible. Coarse (a pun on refine) was also recently created as an open source alternative. These systems provide qualitative feedback on the content of papers, spotting methodological weaknesses and mathematical errors. They seem to work pretty well, and many academics report bitterly that they exceed the average quality of typical peer reviewers. But there are few evals here either. What evals exist so far involve using LLM-as-judge (circularity problems abound) or comparing against human reviews of questionable quality. What you’d ideally want is an eval that measures capturing known errors in papers3. Reproducibility and robustness Another active area has been using AI agents to automate computational reproducibility4 and robustness5 checks in papers that report numerical results. For more recent papers where data and code are available, AI agents can see whether they can re-run the analyses and produce the numbers reported in the published paper. In addition to a handful of individual academics who have been experimenting using Claude Code for this, the Institute for Replication is a leading group working on building an end to end system. The evals related to this problem are the most mature, with CORE-Bench (Siegel, Kapoor, Narayanan 2024) and PaperBench (OpenAI 2025) available to benchmark agents on this task. There is also work on getting AI agents to test alternative ways of analyzing the data to ensure the results are robust to small analytic design choices. Synthesis This is the most underdeveloped area where significant investment is required. Although some automated evidence synthesis systems exist — for example, otto-sr is building an AI agent to write systematic reviews — none of these incorporate the full range of paper level signals to weight evidence appropriately. Nor is there anything like an eval or a gold standard for a good systematic review. Arguably Cochrane reviews are the closest we have to gold standard human systematic reviews, though I’ve heard academics in the know complain about their uneven quality. A key question for a synthesis platform is how to weight anomalies and methodological issues in assessing the quality of a piece of evidence. This is an unsolved problem and one I’m very keen to work on. Continuous updating There are many pieces of basic infrastructure available for monitoring for new research and initiating updates. OpenAlex is the current open citation graph. Retraction Watch integrated into Crossref in October 2023. Scite tracks how citations support, contrast, or mention prior claims. The Living Evidence Network demonstrated continuous-update workflows in clinical guidelines. Engineering this is a relatively straightforward task. When you look over this technical architecture and all the progress being made, it’s hard not to be optimistic that a living guide to scientific evidence will be built. The stakeholders are ready The social infrastructure for this is starting to coalesce — it’s not just a pie in the sky academic exercise to imagine this coming into existence. Institutions like the Center for Open Science, the Institute for Replication, the INSPECT-SR, the Living Evidence Network and more are all working on scaling work to improve research quality. Funders are also aligned. The Sloan Foundation has funded living evidence work through COS. Coefficient Giving supports the Institute for Replication and COS. The Astera Institute and the Institute for Progress have shown interest in this space. NIH has established an Office for Replication and Reproducibility. Although there are (very unfortunately) serious headwinds in science funding generally, there is an active group of funders interested in metascience. A brief word about what I’ve been doing at RDI. First, as a Visiting Scholar at Berkeley I’ve been actively figuring out how a non-profit and a public university can conduct and make public the results of large-scale academic article data mining. With some of the money I raised from donors, I commissioned a legal analysis of recent case law and publisher text data mining (TDM) agreements in order to understand whether a massive open data mining of academic articles is possible (with caveats, it is). I’ve also been working to bring together stakeholders in this space, and identify gaps. I’ve also been doing some software development in this space, with more to come. A pilot proposal The assumption undergirding all of this is that an AI, given all this information, would make the right judgment about a scientific claim with lots of conflicting evidence, weighing all the factors appropriately. That’s the hypothesis we need to test. Randomized control trial research is the best place to focus on first. RCTs are used to make many of the important decisions in society - from medical trials to public policy changes. And they use a relatively uniform set of inferential statistics with lots of known and available diagnostics. Behavioral science experiments, within the broader realm of RCTs, should be first used as a testbed whose results can be generalized. Because behavioral science is at the vanguard of open science practices, replications abound (there are thousands of them) to serve as ground truth training data. Key Hypothesis Therefore the pilot would test, in behavioral RCTs that have been replicated, whether the quality of evidence for a claim can be used to accurately predict whether that claim will replicate. Secondary Hypotheses Compared to claims that replicated, non-replicated claims demonstrate a greater share of forensic anomalies in their source literatures. Hypothesis level claim and statistic extraction is accurate enough to scale living evidence without onerous human review costs. Replication prediction is more accurate than prediction markets6 or journal prestige. If all the different quality signals we gather do accurately predict which studies will replicate, then we can use that model to score evidence to power the living evidence layer. Why this is informative regardless of outcome If the pilot succeeds, the architecture extends to medical RCTs (where Living Evidence already operates and integration is mostly about claim representation), then to slices of basic biology with stable replication structure. If it fails, the field learns which quality signals are load-bearing and which ones metascience has oversold. Either result is a contribution to knowing what the literature supports. Implications for funders Because this burgeoning ecosystem of builders already exists, a well-informed philanthropic or government funder could play a crucial catalyzing role in bringing this future about. They could play at least three roles: creating open structured datasets, publishing open benchmarks and incentivizing the solving of key technical challenges. First, open archives of papers that the government maintains, like PubMed, could be turned into structured data amenable to large scale metascience and claim aggregation. I know the US government already has an interest in doing this, though some key open questions remain unanswered. How do you determine the best models and systems for accurately extracting information from papers? How can you establish a robust way to allow researchers to flag errors and correct them? And finally, how do you create a legal regime in working with publishers to maximize the scope of available papers? For the latter, a university or a private philanthropy may be better positioned to make structured data publicly available under journal subscription terms or fair use. Philanthropists or government funders could also coordinate to create or commission benchmarks that evaluate whether important problems have been solved. For example, an open benchmark for claim extraction from a range of different scientific article types would be extremely helpful. Ensuring the underlying data are accurate is vital for creating these evaluations. I’ve discussed opportunistically using various human-created datasets for this purpose, but a consistent problem is that errors in human data make it difficult for them to serve as a gold standard. Finally, with structured data and benchmarks available, the government or private philanthropy could use them to incentivize groups to develop machine learning systems that meet these benchmarks. Prizes are one potentially valuable tool for this. For example, you could establish a prize for a system that accurately updates a living meta-analysis for a small set of claims. Prizes are particularly useful as signals of problem importance, and can help create vibrant ecosystems of public and private research—see, for example the role the government played in kickstarting the current work on nuclear fusion. Conclusion The drawbacks of the current scientific publishing system are known. Scientists agree, metascientists agree, philanthropists agree: the published PDF plus citation graph isn’t the right substrate for maintaining a representation of the evidence base in science. The pieces needed to build the alternative either already exist or are rapidly taking shape. The community is forming around exactly this problem, with concrete partnerships and shared infrastructure. A pilot should start on behavioral science RCTs because that’s the slice of empirical science most amenable to legibility, where replication ground truth is richest, and where the failure modes are best documented. What’s been missing is the galvanizing mission to assemble these pieces into something that works. That’s what I’m proposing to build. *** 1 I have a broader field map that I’ll release publicly soon. This is me, building in public! 2 If this is something that you are excited about, please reach out and talk to me. 3 More on this very soon too! 4 This tests whether, given the code and the data, you can get the same statistics as reported in the published paper. 5 This tests whether the results are the same as a paper’s given alternative analytical decisions in conducting the analysis (like outlier omission). Closely related is the idea of a “multiverse” where you come up with many different ways of answering the same underlying research question with the same data, and test whether the results hold in all those alternative methods. There’s been work on the latter as well. 6 Some of the replications, e.g. those from the SCORE project, had paired the experiments with forecasts from prediction markets. So we get to look at this for free.
NHL viewership maintains post-Olympic glow through conference finals
The NHL is maintaining its strong viewership pace heading into the Stanley Cup Final. Viewership for each of the league’s conference finals saw near-50% increases on both NHL broadcast partners. ESPN’s coverage of the Western Conference Finals, a Vegas Golden Knights sweep over the Colorado Avalanche, averaged 2.2 million viewers, up 44% versus last year’s…
How Disney World Cast Members Maintain 260+ Acres at ESPN Wide World of Sports
Play ball! But what’s a game without a field to play on? Here at Walt Disney World, we have a team of cast who are growing the game – literally! Year round, the Sportscape (that’s sports + landscape) team maintains more than 30 fields at the 260+ acre ESPN Wide World of Sports Complex which
Sunlight isn't enough to treat Vitamin D deficiency
Vitamin D is a crucial nutrient that maintains bone health, but some women are deficient.
Accel Entertainment: All Eyes On Chicago
Accel Entertainment maintains steady earnings growth but remains rangebound. Click here to read more on ACEL stock and why it is a Hold.
Expert explains the science, safety, and legal landscape around mifepristone used in abortions, miscarriage care
The U.S. Supreme Court has preserved access to mifepristone—the medication used in the majority of abortions in the United States and in some miscarriage care—for now. The action maintains current rules ...
A hotel check-in system left a million passports and driver's licenses open for anyone to see
The tech company that maintains the hotel check-in system set its cloud storage to public, allowing anyone to access customers' data without a password.
NAMRU Dayton spotlight: Driving Warfighter Health
Lt. Cmdr. Travis Landry's day-to-day responsibilities at NAMRU Dayton are incredibly diverse. On the clinical side, he maintains his operational skills by conducting submarine and physicals and supporting recruiters heading back to the fleet. Notably, he also provides essential medical care for a large, displaced population of Navy personnel in the Dayton area who are far from traditional Navy Military Treatment Facilities (MTFs)—ensuring that these sailors maintain their readiness even while stationed away from the fleet. On the research side, he plays a critical role in human subject safety. Before any study begins, he evaluates participants to ensure they qualify, reviewing their medical histories and medications to guarantee that the research will cause no harm and that the data collected will be accurate.
Tencent Maintains Double-Digit Profit Growth Amid Intensified AI Investment
Tencent Holdings extended its streak of double-digit profit growth in the first quarter.
Dallas Trinity FC blanks Tampa Bay
Trinity maintains its cushion for the fourth and final playoff spot in the league standings.
Illinois maintains high childhood vaccination rates, health department says
Beitar defeats Maccabi Tel Aviv in the capital
Jerusalem maintains a slim one-point lead over Hapoel Beersheba in the title race, as Yellow-and-blue is fading. Beitar Jerusalem defeated Maccabi Tel Aviv 4-2 over the weekend as four different goal scorers helped the yellow-and-black to the victory at Teddy Stadium and remain in first place with only six matchdays left in the Championship Playoffs.
Political violence is a left-wing issue, not a ‘both-sides’ problem, GOP lawmaker argues
Sen. Eric Schmitt, R-Mo., maintains that political violence is predominantly a problem on the left on 'Kudlow.'
The US-Israel-Iran War and Türkiye’s Defense Industry
Türkiye currently maintains a comprehensive inventory of sea and land-based electronic warfare assets thanks to its national defense industry
Analysis: Silk and steel win the day
Manchester City secured the victory that maintains their growing momentum and applied further pressure on Arsenal through the familiar route of a Erling Haaland winner. Rayan Cherki's goal was the result of a touch of genius and sleight of foot to bamboozle Arsenal's Gabriel and Piero Hincapie before sliding in a perfect finish. After Gianluigi Donnarumma's error swiftly gifted Arsenal a way back into the game, City had to dig deep to show reserves of resilience before Haaland was once more the match-winner.
Kim Kendall maintains control of HD 18 money race
The rookie legislator's lone challenger isn't raising much.
Analysis | Trump tests loyalty of Christian supporters as erratic behavior escalates
The president maintains his hold on the Christian right, but his bluster, fight with the pope and portrayal of himself as a Jesus-like figure strain that bond.
Computer science graduate maintains Carolina Gaming Arena
As the first Digital Services and Gaming Arena coordinator, Alex Ho ’22 helps gamers connect in the Craig Residence Hall space.
U.S. News Ranks UNC Graduate Health Programs Among Nation’s Best in 2026
Rehabilitation Counseling maintains top-tier national standing, Speech-Language Pathology posts significant gains
NCT's Ten leaves SM Entertainment, maintains group ties
Ten, a member of K-pop boy group NCT, has parted ways with SM Entertainment after his contract expired Wednesday. SM said both parties decided not...
MacIntyre holds four-shot lead at Texas Open
Scotland's Robert MacIntyre maintains his strong form with a round of 64 for a four-shot halfway lead at the Texas Open in San Antonio.
Exclusive: US intelligence assesses Iran maintains significant missile launching capability, sources say
Roughly half of Iran’s missile launchers are still intact and thousands of one-way attack drones remain in Iran’s arsenal despite the daily pounding by US and Israeli strikes against military targets over the past five weeks, according to recent US intelligence assessments, three sources familiar with the intel told CNN.
‘Ahead of his time’: Donation gives BRAF ownership of Newtron Group
Founder of billion dollar company The Newtron Group prepared for the company to be donated to the Baton Rouge Area Foundation more than a decade prior to his July 2025 death. The donation will ensure that the company maintains its employees, leadership and contributions to charitable causes dear to the founder.
Sharing her passion for science
By Danielle Rush Communications Specialist, Indiana University Kokomo Hisako Masuda, Indiana University Kokomo professor of biochemistry, was honored by the Indiana Academy of Science (IAS) as its 2026 Distinguished Scholar. The award is given to an individual who is recognized by the IAS as having an exceptional record of scholarship. Recipients are selected from nominations submitted to its awards committee. “I was surprised,” said Masuda, who joined IU Kokomo’s faculty in 2013. “I feel there are many good scientists in the Academy, so I wasn’t expecting it at all.” Patrick Motl, dean of the School of Sciences, said the Academy recognizes up to one member per year, and that Masuda is the second or third IU Kokomo faculty member to receive the commendation. “Clearly this speaks to the strength of Dr. Masuda’s accomplishments in research and scholarship and that her work stands out amongst her peers in Indiana,” said Motl, who received the award in 2019. “Many of the institutions that participate in the IAS are undergraduate institutions or primarily undergraduate institutions, but even having that caveat, Dr. Masuda has built and maintains a very active research program in her lab, working exclusively with undergraduates. She is passionate about science and can share that passion with her students. To carry on a quality research program with so many students involved in so many projects is truly remarkable and I am glad that the IAS acknowledged that for Dr. Masuda.” The IAS specifically commended her for involving more than 50 undergraduates in her research in bacterial metabolism, genomics, and their phenotypic plasticity at IU Kokomo, and publishing 23 articles with many student co-authors. Masuda’s current work primarily focuses on biodegradation and chemical repurposing of nylon. Using soil bacteria, her lab studies bacterial biodegradation of nylon and other environmental pollutants. She applies principles of green chemistry while developing a method to convert nylon waste into other nontoxic polymers. In collaborative work with health scientists, her lab investigates gut microbiomes of Indiana native birds as well as human subjects in a clinical study. She became interested in converting plastic waste while earning her Ph.D. at Rutgers University, working on methods to remove environmental waste not using chemicals or other intrusive methods. She learned about Nylon 11, which is used in pipes for transferring oil, interior components for cars, catheters, and in other industrial hard plastics. Nylon 11 is nontoxic, she added, so it is safe to include students in the research. “Those are considered to be nonbiodegradable, and have to go to a landfill,” she said. “I thought if we could come up with a way to biodegrade it, that would make some kind of impact.” Eventually, she wants to develop a product that would convert nylon waste to something useful, and to reduce waste and microplastics in the environment. “That would be my goal at some point, that we can make that change, and also make people more aware of their use of plastics,” she said. “I hope students stop to think about what we can do as scientists to address issues currently impacting us.” She appreciates the IAS for its support of scientific research at Indiana institutions, and IU Kokomo and the School of Sciences for providing funding for students to attend the Academy’s annual meeting. She added that IU Kokomo has also supported her research with funding from the School of Sciences and Academic Affairs. “Without that, I couldn’t do my research,” she said. Masuda has also earned a Senior Research Grant from the IAS, IU Kokomo’s Distinguished Research Award, and the IU Kokomo Junior Faculty Annual Research Award. She is a Fellow of the Indiana Academy of Science. Education is KEY at Indiana University Kokomo.
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The disunity of science is a feature, not a bug
Mathematical models wield miraculous power, but mistaking them for reality has trapped science in a destructive quest for a “Theory of Everything.” Physicist and philosopher Ragner Fjelland argues that this leads to bloated, Frankenstein theories kept alive by clumsy, ad-hoc amendments, which reduce rather than boost science’s power. Fjelland calls for a radical shift in our attitude: we must reorientate towards creating entirely new theories, celebrating rather than lamenting disunity and diversity in science. Science, from the scientific revolution in the seventeenth century to the present day, has more or less developed in a “reductionist” way. The fundamental assumption is that all sciences may be ordered in a hierarchy that can be represented as an upside-down pyramid. At the top we find the human sciences, and at the bottom physics. Strong (or “ontological”) reductionism maintains that all theories at one level can be completely reduced to the lower level, all the way down to theories of atoms and elementary particles, or whatever is “at the bottom.” In the end, all diversity in the world can be unified in one fundamental theory. Hence it is called a final theory, or a Theory of Everything.One of the central figures in developing the idea of a Theory of Everything is the Dutch theoretical physicist Gerard 't Hooft, who received a Nobel Prize in physics in 1999 for his work. He emphasizes the non-empirical status of the theory:There exists no closely resembling alternative theory. This means that any slight change brought about in the rules would make the theory unlikely or inelegant. The theory will be a "package deal": take it, or leave it. This should hold both for the local laws and for the boundary conditions.This endeavor is not new. On the contrary, it goes all the way back to the birth of Western philosophy 2,500 years ago. The Babylonians made regular astronomical observations during a period of 600 years, from 747 BCE until 150 ACE. They developed mathematical techniques to predict astronomical phenomena, but they made no attempts at explaining them. However, the Greeks developed models, both material and theoretical, to explain the observed phenomena.The best example is Plato’s late dialogue Timaeus. Here he introduces a divine craftsman, the Demiurge, who has constructed the universe according to an original plan. Plato seems to have thought that the original plan is what is actually real, while the material world is merely an imperfect realization of it. He therefore does not, in the Timaeus, reconstruct the material universe, but the original plan, which can then be used to explain the material universe.Plato’s aim in producing a theoretical model is to reconstruct the original plan. That is what he carries out in Timaeus—and some modern physicists have embarked on the same project. For example, Einstein’s basic attitude is reflected in the title of Abraham Pais’ biography: “Subtle is the Lord...,” echoing Einstein’s comment, “Subtle is the Lord, but malicious He is not.” In an interview Einstein compared our situation to a child who enters a huge library. The child knows that someone has written the books, but he does not know the languages in which they are written. He suspects that there is a mysterious order, but he does not know what it is.___“We have all been working in what Husserl called the Galilean style; that is, we have all been making abstract mathematical models of the universe to which at least the physicists give a higher degree of reality than they accord the ordinary world of sensation.”Steven Weinberg, Nobel Prize in Physics (1979)___This Platonist view is contrary to a widespread impression of science, symbolized by the picture of the “father” of modern science, Galileo Galilei, with his telescope. According to this impression, Galileo liberated himself from the dominating metaphysics of his day—basically Aristotelian philosophy—and constructed a telescope that he directed towards the sky, showing that Jupiter has four moons. He also performed experiments with bronze balls rolling down inclined planes and found the law of freely falling bodies.However, in other cases Galileo emphasized the unreliability of our senses. It is easy to see why. He defended Copernicus’ heliocentric hypothesis. According to this hypothesis, we are not at rest at the center of the universe, but moving at a tremendous speed through space. Why don’t we observe this motion? Galileo praises Copernicus because “with reason as his guide he resolutely continued to affirm what sensible experience seemed to contradict.” In other places he directly refers to Plato. SUGGESTED VIEWING The quest for a final theory With Michio Kaku Galileo’s Platonism goes back to his early writings. In The Assayer, published as early as 1623, Galileo compared the universe to a grand book that is written in the language of mathematics, and “its characters are triangles, circles, and other geometric figures without which it is humanly impossible to understand a single word of it.” Therefore, things that cannot be described by mathematics—for example, colors, smells and odors—are not real. They are merely subjective.This division into subjective and objective, advocated by Galileo and his younger contemporary René Descartes, is normally associated with a mechanistic world view, which is regarded as the opposite of Platonism. When we reduce something to, for example, molecules and atoms, we move “downwards.” In contrast, the Platonist moves “upwards,” to abstract entities. However, it only shows that when we address fundamental questions, we should be careful in applying everyday spatial metaphors like “up” and “down.”___Nature is complex, and we cannot in general construct mathematical models that adequately describe the world.___The endeavor of finding a Theory of Everything has been heavily criticized. In 2006, the theoretical physicist Lee Smolin published “The Crisis in Fundamental Physics.” He argued that one of the most fundamental principles of science is that we should only regard theories as scientific if we have the possibility to show that they are false by experiments. Although he did not refer to Karl Popper, other critics have referred to Popper and argued that a theory is not scientific if it cannot be falsified (see for example Ellis & Silk 2014).These were not the first physicists to be anti-reductionists. In 1972, the journal Science published an article by the physicist Philip Anderson with the title “More Is Different.” This is the kind of article a scientist would normally write only after he has won a Nobel Prize. However, Anderson won the Nobel Prize for physics five years later, in 1977. The article is amazing, not primarily because it argues in favor of anti-reductionism in general, but because it argues for anti-reductionism within physics itself. Anderson’s conclusion was:At each stage entirely new laws, concepts, and generalizations are necessary, requiring inspiration and creativity to just as great a degree as in the previous one. Psychology is not applied biology, nor is biology applied chemistry.We may say that Plato started the “unity of science movement,” based on Euclidean geometry as the model of all knowledge. A distinguishing mark of geometry is that all possible constructions can be reduced to a few fundamental principles. We have to acknowledge that this approach has limitations. In general, we can easily model technological systems. In addition, we may construct simplified and idealized models that capture important aspects of systems, from various perspectives and for various purposes. But nature is complex, and we cannot in general construct mathematical models that adequately describe the world. In a complex system, each level has its distinct, emergent, properties that are characteristic of this level. Therefore, a complex system should be investigated at different levels and from different perspectives. Instead of exclusively pursuing a scientific ideal based on the unity of science, we should acknowledge the diversity—or even the disunity—of science.
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