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Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
Scientists turn cancer-promoting protein into a weapon against tumors
Researchers have discovered that a protein known to help cancer cells thrive can also make immune cells more effective at destroying tumors.
Former Beach Boy Al Jardine on Mike Love Health: Speechless, Depressed
Jardine, who's not in regular contact with Love, found himself "speechless" and "really depressed" when he saw the recent footage of Love onstage but knows the Beach Boys frontman doesn't want to stop performing: "He wants to be onstage, but he just doesn’t know how not to do it."
Scientists may have found a clue to why octopuses are so smart
A University of Vienna study suggests the way octopus DNA is folded inside cells may have helped these animals evolve their remarkably complex brains.
Proprietor stitches together new business
Jake Beechler's leatherworking career started when the nylon sheath for his Leatherman tool wore out.
World’s largest shark discovered: what scientists found left them speechless
Off the Atlantic coast, a great white shark pulled onto a research vessel stopped scientists cold and forced them to rethink what they thought they knew about the species. What Ocearch's team measured...
New Orleans’ French Quarter gets its first-ever marijuana dispensary. ‘I’m speechless.’
A cannabis dispensary opens on Bourbon Street, marking the first medical dispensary in the French Quarter. NOLA Cannabis Co. offers free telehealth consultations with a fast turnaround, a flower bar, cannabis education and more.
Lane Kiffin’s Leaked Halftime Speech to LSU Players Goes Viral
The Lane Kiffin era in Baton Rouge began Saturday night when the LSU Tigers faced the Clemson Tigers in primetime.LSU turned the ball over on its very first possession, which led to a Clemson field goal to open the scoring. However, it was all LSU from that point on.Kiffin’s Viral Halftime SpeechLSU entered halftime with […] The post Lane Kiffin’s Leaked Halftime Speech to LSU Players Goes Viral appeared first on HEAVY.
Mamdani Taps RXR’s Rechler for Business Advisory Council
Mayor Mamdani appointed 15 business leaders, including RXR's Scott Rechler, to a quarterly council advising on private-sector policy.
Uli Hoeneß on Musiala health scare: "I go to bed thinking of him"
In an interview with RTL/ntv, Bayern chief Uli Hoeneß revealed that he was “shocked” when Musiala suffered another collapsing incident just days apart. "I was speechless. I go to bed thinking of...
Everyone wants a piece of Luke Kuechly
This originally appeared in Tuesday morning’s edition of The A Block, Awful Announcing’s daily newsletter with the latest sports media news, commentary, and analysis. Sign up here and be the first to know everything going on in the sports media world. When Luke Kuechly walked away from the NFL at 28 years old, the prevailing assumption…
Kuechly, Brees, Fitzgerald, Vinatieri and Craig enter Hall of Fame
Kuechly, who spent his eight-year career with the Carolina Panthers, became the second-youngest player inducted into the Hall at age 35
Luke Kuechly's game film study helped shape Hall of Fame career
His ability to anticipate plays made him a formidable opponent.
Poll: Who Gets Into Hall of Fame Next Year?
The Pro Football Hall of Fame will enshrine its Class of 2026 one week from Saturday, on August 8. The five players being inducted are modern-era candidates Drew Brees, Larry Fitzgerald, Luke Kuechly and Adam Vinatieri, and senior committee choice Roger Craig. For Brees and Fitzgerald, this was their first year on the ballot.
Amazon science meets rare disease innovation
A plant-derived therapy rooted in Amazonian medicine is advancing as a potential treatment for rare and life-threatening intestinal failure conditions
SOUTH CAROLINA STINGRAYS AND MUSC HEALTH ANNOUNCE EXTENSION OF PARTNERSHIP
The South Carolina Stingrays and MUSC Health announced today that they will extend their partnership as the team’s official Healthcare, Hospital and Sports Medicine Provider.
The First Test of Bar Harbor's New Entertainment Rules.
The Bar Harbor Story is generously sponsored by the Bar Harbor Historical Society. BAR HARBOR—The Finback Alehouse was the first real test of the town’s new special amusement permit process, July 7 while eight other permits sailed through the process last week. The permit allows music in places where liquor is served. The town’s ordinance which was recently tweaked for a new process allows for the regulation of noise and hours of activity. The only discussion at the July Town Council meeting was about the Finback Alehouse on Cottage Street, in the heart of Bar Harbor’s downtown district. The Finback’s distinctive design—a front wall that is like a garage door that can be opened and closed—was a key to that discussion. The restaurant, which often hosts live bands, singers, and karaoke, at night, has had one substantiated noise complaint this season, which is documented on its application. According to Bar Harbor Police Chief David Kerns, most complaints about noise happen after 10 p.m., and if the Finback had two more violations within a year, they’d have to stop having music. One town councilor said that he’d have no problem reissuing the permit if the door was down. The permit passed through the process with no conditions. Vice Chair Earl Brechlin moved the motion with two time changes for two holiday weekend dates. It passed unanimously. The council asked the Finback why they’d chosen an indoor license with a wall that can be opened to the street. Dale Stockburger, representing the Finback, said he’d applied for an indoor permit rather than an outdoor structure or partial structure (which is usually applied to tents or pavilions). The restaurant has traditionally had an indoor license. Stockburger said that whether the door is open or closed is immaterial because he now stands outside with a decibel reader to make sure that the music isn’t too loud. OTHER SPECIAL AMUSEMENT PERMITS New Councilor Deborah Vickers worried that she had potential conflicts of interests on two other renewals due to the location of her employee housing. Vickers co-owns the Black Friar Inn. They have employee housing directly behind the Finback, which is also 300 yards from the Bar Harbor Inn, she explained. The Bar Harbor Inn also had a permit up for renewal. The councilors unanimously voted she did not have a conflict of interest. The councilors approved permits at The Bluenose Inn, 90 Eden St, Class A; Acadia Hotel Downtown, 20 Mount Desert St, Class A and C; the Bar Harbor Inn, 8 Newport Dr, Class A, B, C and D; C-Ray Lobster, 882 State Hwy 3, Class D; Holiday Inn Bar Harbor Regency, 123 Eden Street, Class B; Finback Alehouse, 30 Cottage St, Class B; Project Social, 278 Main St, Class C and D; Bar Harbor Beer Works, 119 Main St, Class B and D; and Mainely Meat BBQ Dreamwood Hill, 369 State Hwy 3, Class D. That process is laid out in the Special Amusement Ordinance of the Bar Harbor Town Code which is Chapter 14 of the town code. Special amusement permits have class codes. These are the meanings: Number - how many musicians are allowed by the permit. Class A - Indoor non-amplified entertainment. Class B - Indoor amplified entertainment or dancing. Class C - Outdoor non-amplified entertainment. Class D - Outdoor amplified entertainment. RESIDENCE LICENSES RENEWED AND A TAXI LICENSE The councilors also renewed the licenses for three specific sorts of residences that require that yearly renewal per the town code. The employee living quarters at Atlantic Oceanside Hotel, 119 Eden St and another at 278 Main Street were renewed. The shared accommodations license renewal at 39 Kebo Street also occurred. These are annual renewals. Bernard Taxi Services’ license was also renewed. This license had been added to the agenda at the meeting. Bar Harbor Update on Leaf and Grass Clipping Disposal BAR HARBOR — Bar Harbor residents will still have a place to throw away their leaf and grass clippings this summer. The town’s agreement with EMR in Southwest Harbor for disposing of those items will continue through November 30. The agreement, according to a town press release, will continue “while the Town continues evaluating long term composting solutions and the required state permitting process.” As of July 1, residents bringing their grass and leaves across the island to the facility in Southwest Harbor will have to fill out a property registration card. Each property can throw out up to 85 pounds of the grass and leaves. “Any disposal exceeding the 85 pound allowance during this period will be the responsibility of the property owner at the applicable disposal rate,” the press release explains. LINKS TO LEARN MORE Watch the meeting Meeting agenda QUICK NOTE: We’d released the Bar Harbor Leaf information as a brief, but wanted to make sure that people saw it, so we’ve included it here, too. HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment
CR7 challenges Brazilian journalist: he doesn't like me 🎥
Cristiano Ronaldo “challenged” journalist Marcelo Bechler to ask a question during a press conference this Sunday (5), on the eve of the Portugal vs. Spain clash at the World Cup.The forward asked...
AI and brain-computer interface allow speechless ALS patient to work a full-time job
The hardware isn't new, but a UC Davis research team's machine learning-powered method of translating brain activity in an ALS patient into sentences with 92% accuracy is
Americans Nominated for Franchise-Record Six League Business Awards
The ECHL announced on Monday the finalists for the League Business Awards, which will be presented at the ECHL Summer Meetings in Nashville on Wednesday, June 24.
🚨 Marco Reus brace leads LA Galaxy to narrow win over Real Salt Lake
LA Galaxy have defeated Real Salt Lake 2-1 in Sunday's MLS matchup, thanks to a brace of set-piece goals from Marco Reus. Scorers: Reus 9', 85' ; Marcinkowski 45+4' (OG)After a strong attacking start...
Cher was 'speechless' after discovering her son fathered child with Julie Andrews' step-granddaughter
Cher was 'speechless' after discovering her son, Elijah Blue Allman, fathered child with Julie Andrews' step-granddaughter.
Color of Hockey: Williams helping to grow sport on, off ice in Jacksonville
Works for Sabres ECHL affiliate as goalie coach, director of community development
Morning Flurries: ECHL Strike is Over
Also, a Max Curran highlight from the World Juniors.
Indy Fuel face scheduling questions as ECHL starts work stoppage
The work stoppage resulted in the postponement of the Indy Fuel's scheduled road game Friday against the Fort Wayne Komets and could affect other scheduled Fuel games this weekend.
‘Bo Schembechler would never stop throwing up’: How Michigan’s scandal reveals college sports’ transformation
Legendary Michigan-based columnist Mitch Albom says Bo Schembechler would be sickened by today's college sports landscape where player poaching and money have replaced loyalty in an era unrecognizable to the iconic coach.