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The Pollwatcher: Another fraudulent pollster is out of business, and a third group just disappeared
Why a fake poll got into mainstream poll trackers, how it was discovered and the common thread behind both fake poll scandals this year.
Scientists discover a surprising secret behind the human brain’s wrinkles
Scientists have discovered why common marmosets have unusually small, smooth brains despite starting development much like other primates. The secret lies in subtle changes to brain-building cells that slow neuron production, revealing new clues about how the large, folded human brain evolved.
Extremely rare Viking Age coin from the reign of 'Olaf the Holy' may have been 'held in the king's own hand'
A massive Viking Age hoard that was discovered in Norway contains a rare silver coin featuring "Olaf the Holy," one of the country's first Christian kings.
Scientists Discovered a Snake That Cartwheels Away From Danger, and It’s Hilarious
Researchers used high-speed cameras to reveal how a tiny Southeast Asian snake rolls away from danger at speeds far faster than slithering.
Astronomers discover the lightest pair of neutron stars
Astronomers discovered PSR J1856-0039, the lightest known binary neutron star system. Its two stars orbit each other in 2.36 hours and are expected to merge in about 82 million years.
Lightest-ever neutron star system proves Einstein right about relativity yet again
Einstein's theory of relativity just got put to the test by the lightest binary neutron star system ever discovered.
Scientists Just Discovered That Earth’s Core Is Leaking, and It Has Been for Billions of Years
A new study suggests ancient hydrogen trapped deep inside Earth has been slowly escaping into the mantle for billions of years.
‘Pretty gruesome’: Local business owners speak out after more human remains found in Downtown Portland
PORTLAND, Ore (KOIN) — Portland Police are investigating a second set of human remains found inside a homeless camp. These remains were discovered on Monday, only a week after remains were fo…
The James Webb telescope is watching one of the earliest supernovas in the universe unfold
Astronomers using the James Webb Space Telescope may have discovered a supernova erupting just 1.1 billion years after the Big Bang.
New comet accidentally discovered by space telescope
The ‘happy coincidence’ is currently more than 807 million miles from Earth.
Disney stars Dylan and Cole Sprouse are ‘children of incest’
Dylan Sprouse revealed how he discovered that he and twin brother Cole Sprouse are ‘children of incest,’ due to a wild family history for the ‘Suite Life of Zack and Cody’ stars.
Scientists finally uncover why statins can cause muscle pain
Scientists have uncovered a surprising reason why statins, the widely prescribed cholesterol-lowering drugs that help prevent heart attacks and strokes, can sometimes cause muscle pain, weakness, and even severe muscle damage. Using advanced imaging technology, researchers discovered that statins can attach to a crucial protein in muscle cells and force open a channel that normally controls calcium flow. This causes calcium to leak continuously, potentially damaging muscle tissue.
Gen Z founders want lean teams, but they still crave coworkers
I visited a NYC office full of Gen Z startup founders and discovered why building a company with AI doesn't always mean wanting to work alone.
Cockroach infestation leads to suspension of Chicago hospital cafeteria license
A cafeteria at a Chicago hospital had its license suspended after health inspectors discovered a cockroach infestation.
11th-century 'pizza peel' discovered in Russia doubled as a medieval game board
Archaeologists in Russia unearthed a flat wooden "pizza paddle" that had a board game carved into it.
Student Success Keeps STC Professor Emeritus' Legacy Alive
As he reflects on a teaching career that spanned more than two decades at South Texas College, Professor Emeritus Gilberto Reyes said some of the most meaningful moments came when students discovered they could succeed in careers they once believed were out of reach.
GM Says Apple Wallet Car Keys Coming to These Vehicles
In a late September press release that we just discovered now, GM announced that it has started rolling out Apple Wallet car key support in select Cadillac, Chevrolet, and GMC vehicle models, with additional models to follow over time. Google Wallet and Samsung Wallet will also be supported, with a related Samsung press release mentioning availability in the U.S. and Canada. GM said the rollout will occur as follows, with model years listed in parentheses.
Ovaries may not become ‘stagnant’ after menopause, scientists say
The ovaries may not become “stagnant” after menopause, according to scientists, who have discovered shifts in protein levels after periods have stopped. While more research is needed to examine if the...
Romans may have set fire to Celtic town during conquest to 'humiliate' the enemy, archaeologists find
Archaeologists discovered a first century B.C. military camp that was erected during Emperor Augustus's Cantabrian Wars.
Scientists discover why some people still can’t taste food after COVID-19
Scientists have uncovered a possible explanation for why some people struggle to taste food more than a year after recovering from COVID-19. By examining taste buds from patients with lingering symptoms, researchers discovered molecular abnormalities that weaken the signals responsible for detecting sweet, bitter, and savory flavors.
Scientists reconstruct face of man who lived in Ecuador 3,000 years ago
Skulls discovered in Ecuador's Andes fueled theories about the origins of ancient Americans; a new facial reconstruction supports an Indigenous ancestry, but researchers say DNA testing is needed to settle the question
New Form of Superconductor Behavior Discovered That We've Never Seen Before
It was predicted 20 years ago.
Scientists Simulated the Universe – And Discovered the Milky Way May Be One of the Best Places for Life
Galaxy simulations suggest the Milky Way offers some of the universe’s best conditions for life, while smaller, more crowded galaxies remain less forgiving. Earth seems like a troubled place right now, but at least our cosmic surroundings appear peaceful. But this is not universally true, as explosions, collisions, and other dangers lurk in other places
Scientists uncover 3 key brain pathways linked to lasting depression relief
Researchers have uncovered three brain pathways linked to lasting improvements in people receiving deep brain stimulation for severe, treatment-resistant depression. They also discovered that patients who failed to improve after two years shared a striking pattern: insufficient stimulation of a crucial brain connection. The findings suggest that millimeters in electrode placement could make a major difference in treatment outcomes.
Magic mushroom ingredient takes the fight out of aggressive fish
A psychedelic compound found in magic mushrooms appears to have an unexpected effect: calming highly aggressive fish. Researchers discovered that low doses of psilocybin significantly reduced aggressive attacks in mangrove rivulus fish without disrupting their normal social interactions. The findings suggest psilocybin may selectively calm escalating aggression rather than simply suppressing all behavior.
Physicists create a bizarre new quantum state called a fractional fermi sea
Physicists have discovered a strange new state of quantum matter in which ultracold atoms defy familiar organizational rules, forming a highly excited yet surprisingly orderly configuration called a "fractional Fermi sea." The discovery challenges established quantum theories and hints at exotic quasiparticles that scientists have dubbed potential "super-Fermions."
Scientists discover that male and female skin play by different rules
Scientists have uncovered a surprising difference in how male and female skin repairs and renews itself. By tracking individual skin stem cells in living mice for five months, researchers discovered that female cells work together in a highly coordinated way, while male cells operate more independently. This synchronization, driven by sex hormones, helps explain why wounds heal faster in female mice, especially during the first few days.
Scientists who discovered a third form of magnetism win major physics prize
Physicists have uncovered a hidden third form of magnetism that challenges more than 100 years of established physics. Called altermagnetism, the discovery could transform future computing and electronics while opening an entirely new frontier in quantum research.
New drug reverses severe fatty liver disease by repairing the gut
Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The breakthrough could pave the way for new treatments for liver disease and potentially other serious conditions, including cardiovascular disease.
First-Ever Green Star Discovered, Scientists Take Step Towards "Schrödinger’s Cat In Real Life", And Much More This Week
All the biggest science news stories of the week.
Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain
Scientists have discovered a surprising two-way relationship between sleep and growth hormone, revealing how the brain carefully balances physical recovery with wakefulness. The findings could help explain why poor sleep harms metabolism and brain health, potentially opening the door to new treatments for sleep and neurological disorders.
Scientists uncover mystery of how snail shells coil to the right or to the left
Scientists have discovered a gene that determines whether Japanese snails develop shells that are left- or right-coiling—with implications for understanding the underlying handedness of our own bodies. ...
Scientists turn cancer-promoting protein into a weapon against tumors
Researchers have discovered that a protein known to help cancer cells thrive can also make immune cells more effective at destroying tumors.
Archaeologists discover the oldest dwelling in the Western Hemisphere at a 13,800-year-old site in Alaska
Archaeologists have discovered an ancient base camp in Alaska that has evidence of the oldest dwelling and possibly the earliest domesticated dogs in the Americas.
Scientists Discovered Two Bizarre New Sea Spiders, and One Has Red Eyes and Hairy Legs
They may not be true spiders, but these ancient marine arthropods are stranger than anything crawling across land.
USC scientists discover how to create a never-ending supply of cancer-fighting cells
USC scientists have discovered a way to create a potentially renewable supply of genetically engineered immune cells that can attack cancer and strengthen the body's natural defenses. By growing and modifying immature immune cells rather than mature ones, researchers developed a system that can continuously produce tumor-fighting cells inside the body.
They've done it. Scientists have found a green star. Here's the science behind the new discovery and the technicolour cosmos | BBC Sky at Night Magazine
Astronomers have discovered that white dwarf stars can glow a variety of different colours, including the first known star that glows green.
Scientists discover a plastic-eating “Pac-Man” enzyme with a surprising secret
Scientists have discovered a remarkable “Pac-Man enzyme” that helps bacteria devour certain types of plastic and may offer new hope in the fight against plastic pollution. Researchers found that several biodegradable plastics completely broke down in soil within about a year, while conventional plastic remained largely unchanged.
A quantum highway just one atom high could transform superconductors
Scientists discovered that atomic steps just one atom high can guide quantum vortices through superconductors, making them move more than 1,000 times more easily in one direction than another. This remarkable control over quantum motion could lead to a new generation of ultra-efficient superconducting electronics.
2 giant Ramesses II statues, one wearing a double crown, discovered by man in Egypt
The remains of two Ramesses II statues — one of which would have originally stood around 28 feet tall — were found by a villager in Egypt.
'I found the biggest ever haul of organics on Mars.' Meet the scientist at the centre of the search for life on the Red Planet | BBC Sky at Night Magazine
Dr Amy Williams and her team discovered the largest collection of organic compounds on Mars in a sample collected by the Curiosity rover.
She Was in the Best Health of Her Life. Then Came Breast Cancer
At 40, Miami Pilates instructor Monica Larcada was active, health-conscious and feeling better than ever. When she discovered a breast lump, however, she acted immediately. Her diagnosis of invasive ductal carcinoma launched an intensive treatment journey — and changed the way she thinks about health, strength and gratitude.
Scientists May Have Discovered One Way Microplastics Could Harm the Body
Plastic is usually inert, but in a new lab study, microplastics in water spontaneously produced damaging free radicals. What does that mean for the human body?
Scientists establish new genus of deep-sea 'spaghetti worms'
Scientists have announced a new genus of deep-sea segmented marine "spaghetti worms" with suction cups on their bodies, showing just how much undiscovered biodiversity is out there in the deep seas around ...
Chinese pottery discovered in Great Zimbabwe reveals medieval African empire's vast connections spanning thousands of miles
Archaeologists excavating a medieval African kingdom have discovered pottery from eastern China, revealing connections across continents.
Commonly prescribed blood-pressure drug may stimulate 'healthy' brown fat
Scientists have discovered that the drug losartan, commonly prescribed for high blood pressure, boosts brown adipose tissue activity in mice, enhancing their metabolism. This indicates that repurposing ...
Flightless Jurassic bird was like a carnivorous pheasant with killer claws
An early bird with many dinosaur-like features discovered in China seems to have been a fast-running, land-based carnivore with killer claws.
Scientists discover how harmful “zombie cells” hide from the immune system
Scientists have discovered a protein that may help harmful aging cells hide from the immune system, allowing them to accumulate and fuel age-related health problems. Blocking the protein in mice reduced these cells and inflammation while improving blood sugar regulation and strength, offering a promising new direction for anti-aging research.
Gigantic prehistoric snake discovered in India may have been one of the largest ever
A massive prehistoric snake discovered in India may have rivaled the largest snake ever known. Called Vasuki indicus, the 47-million-year-old giant could have reached up to 50 feet long, making it comparable to the legendary Titanoboa. Scientists believe its enormous body made it a slow-moving ambush predator, similar to a modern anaconda.
Scientists discover 'D-rex', a giant fungus from Chinese forests whose unique lineage dates back 65 million years
Deep in the forests of Yunnan, China, scientists have discovered a "fungal giant" that challenges our understanding of how large fungi can become. The newly described species, Dianjunus rex, produces ...
Pope Leo's lung surgery: What we know
Pope Leo is set for lung surgery after doctors discovered a nodule during a routine checkup. Here's what to know.
Microbe Discovered With One of The Smallest Genomes on Record, Pushing The Bounds of What It Means to Be Alive
What is an organism, anyway?
Byepervisor Reborn Cracks the PS5 Hypervisor on Firmware 13.60, but Developers Warn It’s Not Useful to Regular Users Yet
Byepervisor Reborn is a newly discovered PS5 exploit that could greatly expand what modified PlayStation 5 consoles can do on firmware 13.60.
Physicists discover “astonishing” property of light that defies expectations
Scientists have uncovered a surprising hidden ability of light that allows it to develop spinning, twisting behavior as it travels through empty space, without special lenses, mirrors, or materials. Researchers discovered that light’s internal geometry can naturally produce left- and right-handed patterns, challenging long-standing assumptions about how light behaves. By carefully arranging a beam’s structure, scientists can control where and how these spinning patterns emerge, unlocking a new way to manipulate light.
How worried should Catholics be about the pope’s health?
Pope Leo XIV announced on Sunday that he will undergo surgery this week to remove a “nodule” from his lung. The pope made the announcement at the end of his Sunday Angelus address, asking for prayers. “Dear all, recently, during some checkups, the doctors discovered a nodule in my lung. It was detected at a very early stage and was well-localized,” Leo said. “The doctors felt it was necessary to intervene, and so, following their advice, I decided to have surgery to remove it. The procedure is already scheduled for the next few days. I thank you for your spiritual support and I entrust myself to your prayers.” The Vatican press office subsequently added that Leo is scheduled to undergo surgery at the Gamelli hospital on Tuesday, Oct. 13. The pope is expected to spend up to a week in the Gamelli recovering, after which, for the moment, he is still expected to undertake his largest and longest to-date Apostolic journey, heading to Argentina, Uruguay, and Peru, beginning Nov. 6. Prayers have, understandably, poured in from dioceses around the world, accompanied by the best wishes of heads of state and international institutions. So how worried should Catholics be for the health of the pope? The Vatican’s messaging around Leo’s pending surgery is, in many ways, a new approach to papal health issues. But, despite the pope’s personal candour, the Holy See’s messaging perhaps raises as many questions as it answers. Subscribe — Leo’s decision to announce his own medical status and pending hospital stay during the Sunday Angelus is, it should be said, already something of a big deal. Traditionally, the health of popes simply hasn’t been discussed publicly or officially, until circumstances made it absolutely necessary. Memorably, in 2023 Pope Francis was rushed to the Gemelli in an ambulance, exhibiting signs of cardiac arrest according to many close to him, only for the Sala Stampa to put out a statement insisting he was merely going in for “pre-scheduled” tests. That Pope Leo has decided to announce his condition himself, with remarkable frankness, is a significant comms policy shift around the Apostolic Palace. This might reflect a deliberately more open posture, as opposed to the traditional, otiose evasiveness, and the first fruits of an American pope and American prefect of the Dicastery for Communications favoring honesty as a baseline. Equally, it must be allowed, it could be that the pope’s situation is serious enough that there would be no keeping it under wraps or playing it off, and the decision was made to be as open as possible to head off speculation about the papal health. Certainly, Leo appeared to make every effort to sound reassuring — stressing that, whatever the diagnosis is, exactly, it is “well-localized” and “early stage.” Of course, for everyone listening, talk of a “nodule” in a lung will immediately send thoughts — and prayers — running to concerns about words not used, like “cancer,” “tumor,” “begnin” or “malignant.” To be clear, none of those words may yet be medically appropriate. And there is every reason to believe and assume that Leo is giving almost as much information as he may have himself at this stage. But the context of the pope’s announcement and the timing of his surgery do reasonably raise reasonably serious concerns for Leo. We don’t know, and this isn’t to say anyone has the right to expect to know, when the routine medical checks made this discovery. It could have been last week, last month, or even earlier. As such, it isn’t really possible to say with what kind of urgency Leo is being brought in for surgery. However, there is clearly some serious urgency to the matter. Leo making the announcement and going into hospital this week, of all weeks, means he is having to miss the balance and conclusion of his global meeting of the heads of the world’s bishops conferences, which he convened in Rome this week. That, as the Vatican has announced, has meant some serious changes to the schedule, with the newly minted dean of the College of Cardinals, Cardinal Tagle, subbing in for the closing Mass on Wednesday, and the meeting’s organizers announcing that the final working document/summary of the meeting being delayed until Leo can read and feed into it. Those changes suggest that the timing of Leo’s surgery isn’t of his own choosing, and he is acting on the best medical advice he can get by moving urgently. Had this issue been discovered weeks ago, it seems reasonable to assume the pope would have seen it dealt with before the meeting began. And were it possible to delay it, even by a few days to allow the meeting to conclude as scheduled, the expectation would surely be he’d have opted for that. It cannot be excluded that Leo is simply having to fit in with the schedules of his medical team, but a man who occupies arguably the most important and prominent role in Italy, if not Western Europe, could generally be assumed to be the one whose calendar others work around. All this points to a very recent medical discovery leading to a “days matter” diagnosis, or at least suspected possible diagnosis. Of course, another factor weighing in the balance is Leo’s upcoming apostolic visit to three South American countries, including a return to Peru, where he spent many years as a priest and bishop. It is entirely possible that the doctors, and the pope himself, are more concerned about the potential knock-on effects of surgery, and the time needed for recovery, for a 71-year-old — even one as physically sound and actively sporty as Leo. The pope is due to depart Rome November 6 for his 10-day three-country trip, returning on Nov. 17. It may be that Leo has simply made the decision to allow maximum time for his own post-op recovery, and even allow for potentially unforeseen circumstances, so that he is at full strength for the landmark trip. While it might be an inconvenience, and clearly a last-minute wrench in the works for the Amoris meeting, it is possible that Leo simply weighs the importance of that conference more lightly in the balance than even the possibility of missing his homecoming trip to Peru, or even having to scale back his itinerary for the trip. If that is the case, it would suggest a real abundance of caution by the pope approaching his Latin American tour, and a sobering indication of where Leo ranks the non-synodal meeting currently underway in Rome. In any event, what can be said for certain is that the pope having to take this, of all weeks, out of his schedule for surgery and an extended hospital stay is extremely unfortunate timing. It is clear that this is a decision Leo has made on the advice of his doctors. Together, they clearly consider that the risks of delaying, even by a little as a few days, represents an unacceptable risk for the pope. Even expecting and allowing for Leo’s full and speedy recovery, that should be a very sobering thought for Catholics everywhere. Subscribe
Scientists discover vanilla’s hidden healing potential
Scientists have discovered that vanillin, the compound that gives vanilla its distinctive flavor, has powerful properties that could help fight infections, reduce inflammation, and promote wound healing. The inexpensive, widely available ingredient could one day become an important component of advanced wound treatments and regenerative medicine.
EA Producer Announces Wing Commander 3 Remaster
Using recently discovered master tapes of its live action sequences, one of the crown jewels of '90s PC gaming could make an unexpected comeback
New Apple TV 4K, HomeView, and HomePod Mini: 16 Details Just Leaked
Just two days before Apple's "Welcome home" experience in New York, Bloomberg's Mark Gurman has leaked several details about the new products set to be unveiled, including an all-new smart home hub, a HomePod mini 2, and a new Apple TV 4K. Here is an all-in-one summary of the details shared by Gurman:Apple's home hub with a touch-enabled display will be named HomeView, seemingly confirming a trademark filing discovered by MacRumors.
Pope Leo to have surgery to remove lung nodule
Speaking during his regular Sunday blessing, the American-born pope said doctors discovered the nodule in a localized, “very initial phase.”
Pope Leo XIV Announces Health Scare During Sunday Service
Pope Leo says he will undergo surgery after an early-stage nodule was discovered on his lung.
Scientists make stunning discovery that could help explain why life exists
Scientists have discovered that the universe's fundamental physical constants may be finely balanced to make life possible. Even tiny changes to these constants could make liquids too thick or too thin for essential biological processes, potentially preventing life as we know it. Surprisingly, these life-friendly conditions existed billions of years before living cells appeared. The findings raise intriguing questions about why the laws of physics seem so well suited to life.
ALDS Game 5, White Sox vs Guardians Chat and Discussion
Yay, more playoff baseball. Here is your Battery Power ALDS Game 5 Chat and Discussion. However, you’re not limited to this. It’s also for whatever. There are some football games going on as well. I’m losing weight to the tune of 10 pounds in 4 weeks. My kid just discovered Teenage Mutant Ninja Turtles. It’s […]
Skull Of An Extinct Crocodile Found In The Rocks Used To Build The Pyramids, Most Distant Fast Radio Burst Yet Discovered, And Much More This Week
All the biggest science news stories of the week.
Phantom Blade Zero's Fast-Paced Action Took 15 Years, Two RPG-Maker Games, And A Whole Lot Of Money To Bring To Life
S-Game is finally nearing the release of Phantom Blade Zero, and as part of previewing it one last time, I discovered this game has a whole lot of history
Bronze ring with Lighthouse of Alexandria engraving discovered at palace on submerged island in Egypt
A bronze ring that depicts the Lighthouse of Alexandria has been discovered underwater in the remains of an ancient palace.
José Ramírez, just in time to save the Guardians' season, has rediscovered his MVP form in ALDS vs. White Sox
Low-cost Android phones ship with residential proxy malware
A malware campaign dubbed 'Midnight Mimosa' has been discovered on low-cost Android smartphones that ship with malicious software embedded in their firmware, allowing attackers to silently install apps, perform ad fraud, and turn devices into residential proxies.
No More Missed Zygarde Cells! 5 Big Quality of Life Changes Are Coming to Pokémon GO
Scopely has announced a series of gameplay and quality-of-life updates that will be coming to Pokémon GO! They shared that they are intending to ‘make your adventures as fun, intuitive, and accessible as possible’, so let’s see what will be changing. Zygarde Cells discovered on a Route will now be received as a reward when […]
Webb Measures Distance to Farthest Fast Radio Burst, Suggesting Origin
First discovered in 2007, fast radio bursts are enigmatic, millisecond-long flashes of radio emission from the distant universe. Their origin remains
"That's not a real job": how one RCOB student turned soccer into a sports marketing career - Gary W. Rollins College of Business
Maia Pentecost is a marketing student at the Gary W. Rollins College of Business at the University of Tennessee at Chattanooga. Originally from Clarksville, Maia discovered her path into sports marketing in high school and has since turned that passion into a role as community relations coordinator for Chattanooga Red Wolves SC. In this student… Continue Reading
"That's not a real job": how one RCOB student turned soccer into a sports marketing career - Gary W. Rollins College of Business
Maia Pentecost is a marketing student at the Gary W. Rollins College of Business at the University of Tennessee at Chattanooga. Originally from Clarksville, Maia discovered her path into sports marketing in high school and has since turned that passion into a role as community relations coordinator for Chattanooga Red Wolves SC. In this student… Continue Reading
Did AI find a new gene-editing tool? Why Anthropic’s ‘autonomous discovery’ is sparking controversy
Anthropic’s claim its AI agents discovered an unusual pattern in viral DNA similar to what’s seen in the gene-editing tool CRISPR Cas-9 has set off a wave of skepticism and controversy. Here’s what to know.
Largest 2D map of the universe helps scientists discover new gravitational lenses
Using data from the DESI Legacy Imaging Surveys, with help from artificial intelligence, an international team of scientists has discovered 70 new gravitational lenses—rare cosmic alignments that act ...
Who Won August and September: Original Films or Franchises?
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) I just heard someone say that if you’re reading a pundit or data analyst, and they don’t tell you that they got anything wrong, they’re not a pundit but an “influencer”. I agree with that. You have to tell your audience when you get things wrong, or they won’t (or shouldn’t) trust you as much. Today, we’ve got another edition of “What I Got Right, What I Got Wrong”. In general, I’m patting myself on the back (and patting very hard) about a few things like IP at the box office, LIV golf, horror films, crowdfunding movies, superheroes, and old people going to the theaters. That said, I also made a couple of data mistakes on the streaming bubble popping and HBO’s datecdotes, so I’m not perfect. But first, I need your feedback... Subscribe Follow-Ups: What Should We Call Mid-Budget Movies Which Aren’t Cinematic Enough for Theaters But Are Too Expensive to Make Money on Streaming? After I asked for feedback on what we should call straight-to-streaming films that are too big to pencil out on streaming but not really big enough to resonate in theaters, I got some great suggestions from you all, including... “Moldilocks” from John Aboud “Little Big Indie” from Travis Frick1 “Midflicks” from Jonathan Funke. “Extra-Medium” from Jona Nwuke. (Read the explanation in the footnote.) Between these and Brandon Katz—who suggested “Bermuda Budget Triangle”, “The Platform Gap” and “The Distribution Deadzone”—we’ve got some excellent suggestions. And they’re better than my suggestion, the “Streaming Budget Dead Zone”, so let’s take a poll! The winning entry becomes the new term. Loading... RIGHT: LIV Golf is Fully Bankrupt…Is Anyone Else Next? A few years ago, I was always a bit perplexed at all the articles I’d read praising LIV Golf and their strategy to disrupt the PGA. LIV Golf, a brand new professional golf league, offered PGA stars ten times what they made on the PGA Tour to join their new league. And folks praised this strategy for its initial “success” in that a lot of big names did indeed leave the PGA. Yeah, of course the players came over. LIV Golf paid them so, so, so much more! But LIV Golf hadn’t discovered a way to increase potential revenue. So think about this in basic business terms… They paid much more in costs… …but had no real way to increase revenue. That’s not a strategy! That’s deficit financing. It won’t work unless you bankrupt the competition (and then turn around and pay those same golfers much, much less). It’s not a sustainable strategy and only lasts as long as the company/person/nation backing it decides they’re cool with losing money. For LIV Golf, that meant Middle East oil wealth, in particular Saudi Arabian money. Clearly, the current Iran War has hurt Middle East finances, so they need to trim their more exorbitant spending. And LIV Golf was part of that trimming. This should be a major warning for others. TGL’s parent company, TMRW Sports, just got a $1 billion valuation, despite TGL’s (the indoor golf league) horrible TV viewership of less than half a million viewers per match. Unrivaled, the women’s basketball league, just secured a $650 valuation, despite its horrible TV viewership and a new rival (Project B) entering the scene next year. To relate this to streaming, Hollywood should ask which streamers may have wealthy patrons funding their losses. (Let’s be clear: Google, Amazon and Apple.) Could those patrons lose their appetite? For Amazon, probably not. But Apple has a new boss, so maybe! WRONG: My Analysis of the Streaming Bubble Was Missing a Week I’m going to be congratulating myself a lot today, but I make mistakes too, like this data goof. When I last compiled the data on the decline in TV shows, I was missing one week at the end of June. If you look at the first image, you can see that one week was mislabelled as “July”. Mainly, this image got updated to show a 27% decline, not 29%: This change doesn’t really impact the overall analysis, but it is two percent better. By the way, through the third quarter, the decline increased and it’s now a 30% decrease since 2022. (I’ll write/visualize this in an upcoming article.) But I want you to trust me and my data. Especially these days, when many people are using LLMs that I know are inserting faulty data into their charts, I want to keep earning my audience’s faith. So that’s the accurate data. RIGHT: IP Remains Very, Very Popular In July, I wrote a giant (and I mean giant) article on Backrooms, Obsession, and the box office, going over what we know, what we don’t know about what works in theaters, looking at YouTubers, IP, the horror genre, comic book movies, and a whole lot more. The month of August really tested a lot of my theses and, being honest, mostly supported my arguments. Let’s start with IP. Looking at 8-Aug (the weekend after Spider-Man: Brand New Day came out) to 18-Sep (the weekend that Resident Evil came out, which I think provides a nice bookend to this time period), there were seven films based on pre-existing IP: Resident Evil (2026) ($126 million) Practical Magic 2 ($65 million) _Insidious: Out of the Furthe_r ($65 million) Coyote Vs. Acme ($59 million) Paw Patrol: The Dino Movie ($53 million) Tony ($15 million) Super Troopers 3 ($7 million) Compare those to the notable original films from the past month—I actually could have included more movies, but here are just thirteen, bringing us to an even twenty films—including.... The End of Oak Street ($54 million) Buddy ($26 million) Mutiny ($15 million) By Any Means ($15 million) The Dog Stars ($14 million) Runner ($14 million) One Night Only ($11 million) Hope ($8 million) Spa Weekend ($7 million) The Uprising ($6 million) Teenage Sex and Death at Camp Miasma ($6 million) Onslaught ($3 million) Eli Roth’s Ice Cream Man ($2.8 million) Here’s that in chart form: Five of the top six films in this time period were all based on IP. I made a big chart of films that grossed over $200 million at the box office before Spider-Man: Brand New Day and The Odyssey hit theaters. Let’s update that chart! By the way, if you want to see how I categorized each film—so another bar chart—here it is: I know that many of my fellow critics/pundits/analysts dislike films based on IP and how Hollywood is making so many of them. And I’m sympathetic to this point of view. As I’ve written many, many times before, you need a balance between existing franchises, new IP, and original films. And Hollywood clearly needs to make more films like Resident Evil (a well-made film from a visionary director) and fewer Practical Magic 2’s (which didn’t get critical or customer buzz). But at some point, critics and pundits need to contend with what audiences are telling them: Movie-goers aren’t showing up to original films. Audiences are speaking with their dollars, telling you they want more IP and franchises. You can try to convince studio heads to make fewer IP-based films and franchises, but the data and numbers aren’t there. Instead, critics need to work harder to convince audiences to show up for original films. Aim your ire/concern at the average person, not studio heads.2 Because they’re just making the films that audiences are telling them to make. WRONG: Original Horror Films Didn’t Break Out I’ll be honest, even though I wrote an article casting some skepticism on the horror genre in July, if you asked me to make a prediction, I would have predicted that, in August, a new, original horror film would have blown up. No, seriously, I just assumed that Obsession and Backrooms presaged a change in audience behavior. But none of the buzzy new original horror films from August—Teenage Sex and Death at Camp Miasma, Onslaught (not an action film in spite of the ads), The End of Oak Street, Eli Roth’s Ice Cream Man, or _Buddy—_broke out. To be clear, exactly one of those films (Buddy) had good “ROI”, but again—I try to be specific in my language—none were “popular” in any broad sense of the word. None of them will be “saving” movies theaters like Backrooms or _Obsession_helped save the summer. The new Insidious film and Resident Evil, both based on IP, were far and away the biggest horror films since July. (We’ll see if this changes in October/Halloween season.) RIGHT: Stay Skeptical about Crowdfunding... I’ve long been skeptical about crowd-investing platforms as one of Hollywood’s saviors, mainly because there’s so much hype/buzz. People need to stay more skeptical about more things, explaining both the potential upside but also the downsides. In particular, the media often hypes crowdfunding at the start and never checks in on the actual results after they’ve come in later. And August gave us our first update! _Ice Cream Man—_directed by Eli Roth—grossed $6 million off of a $5.5 million budget. This is a production of The Horror Section, which was one of the first “crowd investing” studios with 2,400 investors, which means that 2,400 investors probably lost money. They certainly aren’t getting as great of returns as if they had just invested their dollars in the stock market. Hopefully Stiletto (Tagline: “Someone’s Going to Make it Rain Blood!”) does better next month. WRONG: Another Data Goof Here’s another data error. When the first episode of House of the Dragon came out, HBO put out that it had 21.5 million viewers in the first three days, and I read that to mean in the US…but no, it was global. So my US-only datecdotes charts shouldn’t have included it. We never got US-only numbers for the first episode, but for the final episode, HBO put out that it had 11 million US viewers. (And that global dropped to 21 million viewers.) Here’s the updated chart (which I’ve since used in the Streaming Ratings Report): Still, this show is absolutely huge. RIGHT: Superhero Films Remain Very, Very Popular After Supergirl flopped, I read a few takes that “comic book movies are going the way of the Western”. Post-Spider-Man: Brand New Day, that take didn’t age well. To be fair, I have a very nuanced take on the superhero genre right now; it’s down right now, for a lot of reasons. But it’s not “dead”. Maybe _Spider-_Man is just a really popular character? I saw that take, and it’s a fair counter-argument. (But pundits arguing that superhero movies were dead should have mentioned this $1.5 billion counter-argument…) But is it just Spider-Man? The next Avengers film already has $50 million in pre-sales (and I was skeptical that that film would do well) and the Avengers: End Game re-release topped the box office two weekends ago (over three original films). And I wouldn’t bet against Batman or Superman. So maybe it’s just Spider-Man, Batman, Superman and the Avengers. Oh, and Deadpool, of course. And Black Panther. And Wolverine. And probably the X-Men. Plus a well-made Wonder Woman or the Hulk film could break out. But that’s it! It’s just those ten characters/teams. Oh, what’s that? Lanterns is also doing well on HBO? (See previous section…) To be fair, I’m actually pretty sympathetic to the argument that more popular characters—like Spider-Man and Batman—anchor more popular films. In fact, I made that exact argument three years ago when I first wrote about the “Marvel-cession”. In many ways, you can blame The Guardians of the Galaxy for fooling Marvel Studios (and the rest of us) into believing that any character could pop. It turns out, the list of iconic characters is probably smaller than most people think. But it’s probably too early to say that superhero films and comic book movies are dead unless “death” means a slight decline over a longtime. RIGHT: Who Killed Theaters? Old People I get frustrated whenever I see headlines or analysis about how young people are “returning” to theaters. As I’ve detailed(for years), young people have always powered the US box office, despite narratives about “kids these days” and their “phones”. Really, what’s changed post-2020/pandemic is that old people aren’t going to the movies nearly as much. This summer, I saw a movie (from an older director) in a theater near a retirement community, and multiple older people at the theater were talking about how this was their first time seeing a movie in years. I dislike personal anecdotes, so YouGov can fill in the data, best summarized by this headline: “Who killed movie theaters? Not the youths”. According to them, 64% of people aged 18-29 have seen a movie in the last year, but only 30% of 65-and-older. 20% of 18-29 have seen a movie in theaters in the last week and 42% in the last month. Here’s the polling data: Most concerning? Many Americans (17%) think theaters are a worse or much worse experience than watching films at home. Slight WRONG: Hadestown Opens Big A live theater capture of the Broadway musical, Hadestown, made $20 million at the US box office, which begs the question: was I wrong to be skeptical about musicals a few years ago? Yes and no. On the one hand, $20 million is a far cry from being “popular”, so yeah, the genre isn’t that popular overall and Hadestown is one of the more popular musicals from recent years (i.e. the “Taylor Swift Data Fallacy” in action). On the other, I doubt filming this cost all that much, and I don’t think that they spent much on marketing, so this is a good source of ancillary revenue. Smaller Updates WRONG: As I mentioned in a Streaming Ratings Report, I underestimated the budget for Enola Holmes 3. It probably cost more like $50 million, if not more. But... I’m not sure that it really matters? At sub-10 million hours, prices have to come down to make this work. WRONG: Netflix is giving Ink a 27-day in theaters! To quote the kids/YouTubers these days, let’s go! Now I might actually have a chance to see Danny Boyle’s latest in theaters. I’d complained about this in a “Coming Soon” section, but I was heartened to read that Netflix is giving multiple films longer theatrical windows this year. RIGHT: Netflix is sending 4-5 films per year to theaters. Netflix is slowly but surely sending more and more films to theaters, as I cautiously predicted earlier this year. For now, it’s just three big films and a number of awards contenders, but still, this is great news. And they’ll be releasing box office grosses! Just this week, Ted Sarandos confirmed that KPop Demon Hunters 2 will come to theaters (and my guess is it performs in the box office top ten at a minimum). WRONG: Angel has 3 million subscribers! How do I know this? Well, they told Deadline, who reported it. I marked this as “wrong”, since they’ve doubled their subscribers in one year but, you know, they don’t really have a hit film to speak of and they’re still losing money. WRONG: Furious was only renewed for one more season. I accidentally wrote “two more seasons” in my latest “Renewals, Cancellations, Un-Orders and Removals Update”. RIGHT: House of David is ending with its third season. In July, Prime Video renewed House of David for a third season, as I just wrote in my latest “Renewals and Cancellations” report. Well, now it’s ending after that third season. Why? As I’ve been writing, its viewership wasn’t great. I got feedback that this show didn’t cost very much, but it cost enough that its limited viewership didn’t save it. WRONG: Adults was a Hulu original! So I missed Adults when it first came out last year; I saw that it aired on FX and just assumed that it was a linear-first program. Turns out, it aired three episodes on FX, but binge-released the rest of its episodes the next day on Hulu. Huh. So I should have covered it last year! But I just wrote about it. 1 “When I was a kid in the 90s, if you wore a t-shirt to school that wasn’t too big and also wasn’t too small, but somehow didn’t quite fit, we’d say you were wearing an “extra-medium” shirt.” 2 As always, a huge exception is Disney, which barely makes anything original anymore.
Did you know Uranus has rings? The story of how scientists made a huge discovery by accident – and triggered an emergency response in the process | BBC Sky at Night Magazine
The story of how astronomers discovered rings around the planet Uranus, as told by one of the team on a long-haul flight that day.
What If You Perfectly Remembered Every Day of Your Life? Turns Out, It’s Not So Nice.
One teenager’s mind replays the past 5 to 7 hours a day. Scientists just discovered what that costs him.
Scientists discovered a crocodile they never knew existed
CT scans helped determine that the fossil unearthed in Egypt came from a distinctly different ancient species.
New crocodile species found in rocks of Egypt's Great Sphinx
A skull from the now extinct ‘Herugavialis cairensis’ was discovered in the 1920s—and is also missing part of its nose.
Earth is in the firing line of a strange new type of cosmic object: a 'microblazar'
Astronomers may have discovered the first known microblazar, a long-theorized object firing a powerful beam of particles directly at Earth.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
57 new species discovered in deep-sea canyon near Argentina
Including ‘Loki the Sea Cucumber.’
Extinct ice age bovine discovered in Siberian cave
Bone fragments show this yak-like animal likely went extinct about 27,000 years ago.
Can we harness the brain's deep-cleaning system to prevent Alzheimer's?
The glymphatic system is the brain's recently discovered network for flushing out toxins. Now, we're uncovering surprising ways to boost it to protect brain health
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Google Pixels could get an all-new way to customize lock screens, for better or for worse
We've dug into the Wallpaper & Style app in the latest Android 17 beta, and discovered a brand-new way to customize your lock screen.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
What scientists discovered about dogs and human emotions
Brain scans show dogs process human facial expressions differently, suggesting they can distinguish between emotions like fear, sadness, and anger.
OPINION | OTHERS SAY: Put an end to resentment politics
American politics is being hijacked not by one ideology, one party or one faith but by influential voices who have discovered that resentment attracts attention, outrage builds audiences and division produces political power.
Chang’e-6 lunar soil contains a surprising magnetic time capsule
Scientists studying Chang’e-6 lunar soil have discovered a previously unknown magnetic mineral in natural Moon samples: a form of metallic iron called γ-Fe. Found inside tiny impact-glass particles, the nanoscale iron can preserve a stable magnetic signal, potentially acting like a microscopic fossil of the Moon’s long-lost magnetic field.
Editorial: Both parties must reject the politics of resentment
American politics is being hijacked not by one ideology, one party or one faith but by influential voices who have discovered that resentment attracts attention, outrage builds audiences and division produces political power.
Rare two-headed turtle hatchling discovered on Cape Cod
A two-headed turtle hatchling is one of three bicephalic terrapins that have been found on Cape Cod over the past five years.
Do dying people know the end is near? This is what science has discovered
People who work around death often describe an unsettling phenomenon: some dying patients seem to know the end is approaching before anyone explicitly tells them. They may start saying goodbye, giving instructions, withdrawing from ordinary routines or talking about deceased relatives. Research suggests that awareness of approaching death does occur in many patients—but it is far from universal, and scientists still cannot explain every way that awareness appears. Some people remain mentally cle
Citizen science project recruits volunteers to search for undiscovered black holes
Cosmic detectives are being called on for an interstellar mission to hunt down thousands of invisible black holes lurking in our own backyard. Space scientists from the University of Southampton need ...
Sapphire discovery could reshape future brain-inspired electronics
Using X-ray beams from Argonne’s Advanced Photon Source, researchers discovered that a substrate beneath a vanadium dioxide film is not just a passive host. Data reveal mutual interactions that could shape future low-power, brain-inspired computing.
Human remains from nearly 80 burials found at UC Davis Health Sacramento campus
Human remains from unidentified burials were discovered by construction crews at UC Davis Health's Sacramento campus in February, officials said.