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Former Wallabies hooker Nathan Charles diagnosed with MND after health decline
Former Australia rugby international Nathan Charles, who overcame cystic fibrosis to play a contact sport professionally, has been diagnosed with motor neurone disease (MND). The 37-year-old Charles, who made his test debut in 2014 and earned four caps for the Wallabies, including a 12-12 draw against New Zealand, revealed he has been diagnosed with the same illness as recently retired National Rugby League star Jai Arrow. MND is an umbrella term for a group of progressive neurological conditions where the motor neurones degenerate.
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Study Reveals Complex, Nonlinear Process of Health Behavior Change Among Women With Polycystic Ovary Syndrome
A recent study in the Journal of Nutrition Education and Behavior (JNEB), published by Elsevier, provides new insight into how women with polycystic ovary syndrome (PCOS) adopt and maintain healthy eating and physical activity behaviors. Researchers found that behavior change is a nonlinear process shaped by factors that can either support progress or lead to disengagement.
Parasites, often seen as villains, may help shape gut and metabolic health
Blastocystis has long been viewed mainly as a marker of parasitic infection. Emerging research suggests that its presence is not necessarily linked to disease, but may instead reflect greater microbial diversity and metabolic health in certain contexts.
The Rockefeller University » Why high levels of the amino acid cysteine are toxic to cells
The findings explain why the cell prefers glutathione, and may lead to new therapies for certain types of neurodegeneration and cancers.
Leading With Light: How Lyla Stays True to Herself While Navigating Cystic Fibrosis
Sixteen-year-old Lyla Faverio is known for her kindness, confidence and determination. She also has cystic fibrosis, but she doesn’t let it take the lead. With coordinated care from pediatric pulmonology and liver specialists at Atrium Health Levine Children’s Hospital, Lyla is taking ownership of her health while holding space for the things she loves.
September brings new name for PCOS
Polycystic ovary syndrome has been renamed polyendocrine metabolic ovarian syndrome to emphasize metabolic health and improve diagnosis and treatment.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
Weight loss surgery can improve reproductive health of women living with obesity
Metabolic bariatric surgery improves menstrual cycle frequency and symptoms of polycystic ovaries in women living with obesity, a new study from the University of Surrey reports.
Western New York lawmakers propose 'Hands Off Our Great Lakes' Act
The proposed legislation seeks to block the president and other federal officials from renaming any of the Great Lakes.
Caregiver Mental Health Tied to Mental and Behavioral Health in Youth With Cystic Fibrosis
Clinically significant mental and behavioral health symptoms remain common among youth with cystic fibrosis and their caregivers despite highly effective modulator therapy, a study finds.
BRINSUPRI® (brensocatib) Approved by Japan's Ministry of Health, Labour and Welfare for the Treatment of Patients With Non-Cystic Fibrosis Bronchiectasis, a Serious, Chronic Lung Disease
—First-in-Disease and First-in-Class Therapy Approved in Japan for Patients With Non-Cystic Fibrosis Bronchiectasis (NCFB), a Progressive Disease That Can Lead to Permanent Lung Damage—...
Pain, stigma and barriers to care: The burden of cysts and fibroids in Africa
As a teenager in Kenya, long before Evelyn Okinyi Owala became a professional bodybuilder, she attended school, spent time with friends and helped her parents around the house. But during her period each month, she said, she experienced excruciating pain, vomiting, fever, lightheadedness, heavy bleeding, pelvic pain and acne.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
PMOS vs. PCOS
The name change of a hormonal condition - from Polycystic Ovary Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS), could improve diagnosis and treatment.
Doctors thought man had brain cancer — they found live tapeworms instead
Doctors suspected metastatic brain cancer in a 60-year-old man, but scans revealed pork tapeworm larvae causing neurocysticercosis.
A surprising discovery reveals the kidney has a secret backup system
Scientists at Mayo Clinic have uncovered a surprising new way the kidneys conserve water, revealing a hidden backup system that works independently of the hormone long believed to control the process. The discovery emerged when researchers testing an old drug called probenecid expected it to worsen polycystic kidney disease (PKD) but found it actually slowed cyst growth instead.
This common women’s health issue is getting a new name. It’s about time.
Polycystic ovary syndrome was always a misnomer. Its new name will help women get proper treatment.
From PCOS to PMOS: New name reflects women’s metabolic health
Global multidisciplinary health professionals and organizations have updated the name polycystic ovary syndrome (PCOS) to polyendocrine metabolic ovarian syndrome (PMOS), arguing that the former is “inaccurate.” They critique that the old name implied greater focus on pathological ovarian cysts, contributing to slower diagnosis, stigma, and limited research and policy framing for the 170 million women living with the condition.
Colorado health startup helping people with cystic fibrosis stay active
The deadly tapeworm spreading across America has reached the Pacific Northwest
A potentially dangerous tapeworm linked to severe, cancer-like disease has now been found in the Pacific Northwest, marking its first detection in wild animals along the U.S. West Coast. Researchers discovered the parasite, Echinococcus multilocularis, in 37% of coyotes tested around Puget Sound—a surprisingly high rate for a region where it had never been reported until recently.
What’s in a name? When it comes to women’s health, sometimes a lot
Polycystic ovary syndrome has been renamed polyendocrine metabolic ovarian syndrome. The change reflects the biological reality of this complex, whole-body disorder.
Ebola, chemical plants and health, hantavirus, common colds, heat and more
As they say, bugs have ears. Public health has had a relentless May. Chemical plant (near) explosions, Ebola, hantavirus, and that's before you even get to the usual suspects: common colds, heat, and ticks. Here’s an attempt to keep you up to speed and, more importantly, what it means for you and your community. But first, an announcement: World Cup The World Cup starts in 15 days (not like anyone is counting down), and we are hanging TVs in the Health Security Operations Center. It’s going to be a gorgeous, chaotic celebration of basically every culture on earth. And it’s going to take a team effort—from communities to individuals, from public health to health care—to keep people healthy. That’s where you come in. If you’re going to the games or live within 30 miles of a stadium, we would love to hear from you. Sign up for a weekly survey here. Thanks to the more than 1,280 people who have already signed up…you will be hearing from us soon!! Global disease “weather report” Hantavirus: Two more cases The global count of cruise ship passengers with hantavirus has now increased to 13 cases (11 confirmed), with three deaths. The two new cases are overseas and among people who were already quarantining: A crew member in the Netherlands. A Spanish national passenger who was quarantining at home tested positive through daily monitoring. They are now in a biocontainment unit. In the U.S., everyone remains negative. There may be more cases, given that the incubation period of hantavirus (the time from exposure to infection) is 45 days. But this week, we will reach a major milestone: the median incubation window is 18 days, and that will pass on May 29. What this means for you: Your risk from this cruise ship outbreak remains essentially nil at this point. Ebola rages on in Central Africa Big thanks to Dr. Craig Spencer, a humanitarian physician who has treated and survived Ebola, for jumping in to provide the YLE community with an update. Craig, take it from here… The combined confirmed and suspected Ebola cases in DRC are now more than 1,000. All signs are pointing to a very long and catastrophic outbreak in Central Africa: This is a vast undercount. We know this because the test positivity rate is hovering around 50%, only 20% of contacts are being traced (and in some areas, no contacts at all), and more cases keep popping up with no known connection. This all points to widespread and undetected community transmission. This is in only a week of detection. Compared to previous outbreaks, the growth is very fast, as the huge West Africa outbreak in 2016 was first detected at 49 cases and rose to 208 cases a month later. It took four months for that outbreak to reach the size of the current one in the DR Congo. The cases are spread out across 16 health zones. There are now multiple epicenters, making containment very difficult. Next door in Uganda, the case count is seven. While this number is low compared to DRC, a concerning development is that two health care workers recently tested positive with uncertain exposure histories. If they weren’t treating known Ebola cases, this means it’s spreading undetected in Uganda as well. On the ground, backlash, including the burning of health centers, has emerged, a pattern seen in nearly every outbreak and rooted in deep community distrust. It often stems from outside actors working in communities without fully understanding or addressing local priorities. Affected populations may recognize the severity of Ebola while still holding other concerns as more pressing, such as where their loved ones are buried. Community trust is essential to an effective response, but difficult to build during an active emergency. It is best established long before a crisis begins. U.S. priorities are made clear, and may backfire. The U.S. Administration has shown that its first priority is keeping Ebola out, with helping end the outbreak in the DRC a secondary concern. That's meant travel restrictions broader than anything we've imposed before — covering travelers from across the region, and reportedly some green card holders and permanent residents as well. For example, just these past two days, news broke that high-risk American travelers will be subject to a mandatory quarantine in Kenya before they are allowed to return. If an American is infected, the U.S. government plans to send them to a hospital it is standing up from scratch in Kenya. (Currently, Americans who were in the area are allowed to return but are diverted to three airports—Houston, Atlanta, and DC—for further screening.) Past administrations have used travel notices and stepped-up screening; this goes much further. At first blush, these strict precautions may sound prudent. But this approach could backfire in three ways: Restrictions this blunt give people every reason to hide where they’ve been and whom they’ve been near — making the people we most need to find harder to track, not easier. They also breed a false sense that this is someone else’s problem. But diseases are humbling. They find the small cracks in even the most impenetrable-seeming defenses. Lives lost. There is no treatment for this Ebola strain, which means survival depends heavily on the quality of the health system. We have that system in the States, but we are choosing not to use it for infected Americans. This is unbelievable and infuriating. (See a deeper dive from me here.) The only real way to lower the risk to Americans — and everyone else — is to end the outbreak in the DRC and across the region. What this means for you: If you have travel plans to this region, it’s time to cancel them. This is a high-risk situation in Central Africa, and CDC released a Level 4 Travel Advisory. There is also great uncertainty if and when the Administration will let you back in. To the general public in the U.S., your risk remains very, very low right now. U.S. disease “weather report” Ticks: past peak season? Good news, especially for people in the Northeast and Midwest: tick numbers continue to decline. Though we are at the peak of the season, this unusually early year is trending favorably. Heat-related illnesses in the North Heat risk is certainly not blanketing the entire country yet, but this week it will be moderate in the Midwest and the Southeast. What this means for you: Be sure to check the CDC HeatRisk tool. A red day isn’t the best day for that soccer game for a kid with asthma, and a stretch of orange days is a great time to check on your elderly neighbor. Common colds surging As far as respiratory viruses go, the only thing really going around right now is the common cold. It is higher this year than last year, but should peak very soon before returning this fall. Spotlight: Chemical plants Over the weekend, YLE California covered the serious situation that unfolded around a chemical plant in Orange County, California. Thankfully, the worst-case scenario (a chemical explosion) was mitigated, but only through luck. The health implications in a densely populated area could have been catastrophic. As the situation was winding down, another chemical explosion struck Washington State. This one was fatal. Health officials say the risk to surrounding residents from chemicals in the air and ground remains low, though the community deserves far greater clarity. Clean air and clean water consistently rank as Americans’ top public health concerns — yet when chemical disasters strike, communities are too often met with reassurances rather than transparency and accountability. Residents near the 2023 East Palestine, Ohio train derailment, for example, are still waiting to understand the long-term impact on their health, with few clear answers. What this means for you: Many are wondering if facilities processing potentially dangerous materials are in their neighborhoods. This interactive map allows you to enter your ZIP code and see all facilities monitored by the EPA, including any violations. Good news Ebola vaccines and treatment for the Bundibugyo species are in development. Two vaccine platforms are being explored, at least one of which may be deployable in as little as 2 months. One vaccine is being developed by Oxford, and the other uses the same biotechnology as the FDA-approved Zaire species of Ebola. (It may provide cross-protection, but it’s unclear at this point.) On the treatment side, two promising monoclonal antibody cocktails are likely to be deployed, though doses are limited and logistical hurdles remain significant challenges. Anni over at The Biotech Tea had a great explainer about the Ebola vaccine gap, if you want to read more. [ The Biotech Tea The Ebola vaccine gap, reading vessel damage, & the Makary exit 🗝️ Paid subscribers get the Biotech Term of the Week at $30/year (~$2.50/month). I try to keep it intentionally accessible, but if cost is ever a barrier, send me a message. A few people asked about expensing your subscription, so I put together a short email template… Read more 6 days ago · 10 likes · Annicka Evans, PhD ](https://www.thebiotechtea.com/p/the-ebola-vaccine-gap-reading-vessel?utm_source=substack&utm_campaign=post_embed&utm_medium=web) Polycystic ovary syndrome (PCOS) has been officially renamed polyendocrine metabolic ovarian syndrome (PMOS), following more than a decade of debate and input from roughly 22,000 clinicians, researchers, and patients worldwide. This is good because the old name was medically misleading, leading to patients without visible cysts being dismissed or overlooked entirely. The WHO estimates that 70% of people with the condition remain undiagnosed. A more accurate name should improve recognition, reduce stigma, and ultimately help the millions of people living with this condition get diagnosed and treated sooner. Poll Loading... Bottom line Public health situations are everywhere right now. Staying healthy takes public health professionals and systems working tirelessly behind the scenes and each of us showing up for our neighbors and communities. Love, YLE Big thanks to Ed Nirenberg for staying on top of the Ebola vaccines, Hannah Totte for all the figures, Dr. Craig Spencer for the Ebola insight, and Dr. Matt Willis for covering the chemical situation in CA. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “Translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
MIT scientists discover amino acid that helps the gut heal itself
MIT scientists have identified cysteine — an amino acid found in foods like meat, dairy, beans, and nuts — as a potent trigger for intestinal repair. In mice, a cysteine-rich diet activated immune cells that released healing signals, helping stem cells rebuild damaged intestinal tissue after radiation exposure. Researchers say the discovery could eventually lead to new dietary therapies for cancer patients suffering from treatment-related gut damage.
Why renaming this common hormonal disorder is a huge deal
You probably know someone who has a condition that, until last week, was known as PCOS, or polycystic ovary syndrome. It affects one in eight reproductive-aged women. But despite it being such a common disorder, patients are often misdiagnosed and have delayed treatment. Now, medical professionals are trying to change that. After 15 years of work, the condition has been renamed to PMOS, or polyendocrine metabolic ovarian syndrome. The new name reflects the real driver of the condition: disruptions in hormones. But how much can changing a name really do? Click here to access resources about PMOS in multiple languages. Interested in more science? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Global consortium renames polycystic ovary syndrome to reflect science
First, it was named after two men. Then, it was named for a false premise. Now, after more than a century, one of the most common hormone disorders affecting women worldwide has a name that reflects the science.
PCOS Gets a New Name in Landmark Women's Health Shift
By HealthDay Staff HealthDay ReporterFRIDAY, May 15, 2026 (HealthDay News) — A major women’s health condition is getting a new name—and experts say it could change how millions are diagnosed and treated worldwide. Polycystic ovary syndrome, or PCOS, will now be known as polyendocrine metabolic ...
PCOS, a condition impacting 1 in 10 women worldwide, gets a new name
Polycystic ovarian syndrome, PCOS, is a common condition impacting women’s health and fertility that often gets underserved. A new name — polyendocrine metabolic ovarian syndrome — may help.
'The name was inaccurate': PCOS gets a new name after years-long effort
Polycystic ovary syndrome, or PCOS, has just been given a new name that experts say better reflects the nature of the condition.
PCOS postpones perimenopause and allows pregnancies at older ages
Only 3 per cent of those with polycystic ovary syndrome reach perimenopause by the age of 46, which may allow them to conceive when older
Scientists discover diet that tricks the body into burning fat without exercise
Researchers found that cutting two amino acids common in animal protein—methionine and cysteine—made mice burn significantly more energy. The boost in heat production was nearly as powerful as constant exposure to cold temperatures. The mice didn’t eat less or exercise more; they simply generated more heat in their beige fat. The discovery hints that diet alone might activate the body’s calorie-burning machinery.
California woman delivers healthy baby after ‘essentially unheard of’ ectopic pregnancy
Suze Lopez found out she was pregnant only days before giving birth, due to fetus hiding behind 22lb ovarian cyst