SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " certain " 100 found 🔀 AI-powered Shuffle
Sign in to save shuffle history.
Regional efforts are needed to address longstanding behavioral health challenges on the Western Slope, report shows
Over the years, Colorado’s Western Slope has developed a range of services to address the region’s behavioral health challenges. Longstanding challenges with funding uncertainty, provider shortages and gaps in care, however, have limited their ability...
Start-Up Claims to Treat a Patient With A.I.-Created Viruses
Certain viruses attack bacteria and can sometimes clear antibiotic-resistant infections. Researchers said they had tailored a virus to attack one patient’s illness.
Tracking tsunamis triggered by extreme weather
As much of Western Europe faced record-breaking temperatures and extended drought this summer, Croatia experienced another weather event that could also set a worrisome precedent.Over the course of two weeks, a series of meteorological tsunamis (meteotsunamis) struck Croatia’s Adriatic coast, alarming both residents and tourists. Social media posts showed flooded seaside promenades and people walking through knee-deep water. Fortunately, no deaths or major damage were reported.In a world where natural disasters seem to be increasing, meteotsunamis — tsunamis caused by rapid weather changes – rarely make headline news. But warming sea temperatures and changing atmospheric conditions may help explain why these phenomena could become more common, especially in shallower seas and inland lakes with wide coastal shelves.“We have definitely become more aware of them, and there have been a lot more reports of these events in the last 10 years,” says Jadranka Šepić, an associate professor of environmental physics at the University of Split whose research focuses on efforts to track meteotsunamis in real time. She is also one of Croatia’s ambassadors for Science Comes to Town (SCTT), a European Commission-funded programme aimed at making research more accessible to the public.Šepić sees two possible reasons for the apparent increase in meteotsunamis. One is that photos and videos shared on social media are providing more empirical evidence, while rising air and sea temperatures could also play a role. The geophysicist “cannot say with certainty” that warming is a contributing factor because research is still ongoing. “But I can say that previously in Croatia we might have had one exceptionally strong event every 10 or 15 years, and one strong event every five years, and within 15 days this summer we had five strong events,” Šepić notes. “This is not typical.”‘A fist against the sea surface’Unlike tsunamis that are triggered by underwater earthquakes or volcanoes, meteotsunamis are caused by sudden changes in atmospheric pressure combined with other rapidly developing weather events, such as thunderstorms. The effect “is like pushing a fist against the sea surface,” Šepić explains. The resulting oscillation intensifies as it reaches shallower water, and “can be far more destructive than a wind-driven wave because meteotsunamis are accompanied by very strong currents than can penetrate much deeper inland.” The meteotsunami, she continues, “then behaves the same as a tsunami — they slow down and grow as the sea shallows, and then grow further in places like harbours due to further shallowing and narrowing. When they come ashore, they can be very destructive — taking everything with them out to sea and then taking it back.”Croatian research institutions have tracked such sea oscillations since the 1930s because the relatively shallow Adriatic Sea is prone to meteotsunamis. The strongest recorded so far was in June 1978, according to the Adriatic Meteotsunami Catalogue, which is supported by the European Research Council (ERC), Croatian Science Foundation and the country’s leading research institutions. During that event, six-metre-high waves flooded the coastal town of Vela Luka on Korčula Island, causing major damage.Other meteotsunami “hotspots” in Europe include the Mediterranean Sea as well the Atlantic coastal shelves off France, Portugal and Spain. In June 2006, a meteotsunami with five-metre-high waves swept through the harbour of Ciutadella in Spain’s Balearic Islands, causing widespread damage to boats. Several less powerful events were reported in the Balearics and off the coast of Spain this summer, leading to some beach closures.Forecasting is challenging because of how quickly meteotsunamis can develop and their uncertain trajectory. Šepić is involved in two ERC-funded research projects — SHExtreme and MeD-Track — aimed in part at strengthening monitoring and real-time data collection. Access to accurate and immediate information is essential for early-warning systems.Early exposure to meteotsunamisŠepić first learned about meteotsunamis from her parents while growing up in Croatia. She later had the opportunity to investigate these events during her master and doctoral studies in geophysics at the University of Zagreb. The geophysicist has also conducted research at the Institute of Oceanography and Fisheries in Split, the University of the Balearic Islands in Palma de Mallorca and the Institute of Ocean Science in the Canadian province of British Columbia.Projects like SCTT are important to raise awareness about research and inspiring young people to pursue studies and careers in science, notes Šepić. She credits her colleagues at the University of Split and the Institute of Oceanography and Fisheries for their community outreach and engagement in the European project, which includes partner universities and institutions in Brest (France) and Kiel (Germany). As an example of town-gown collaboration, Šepić highlights her own university’s ‘Oceanographers on the Island’ programme. This initiative offers workshops and hands-on learning for children living on numerous Croatian islands.“It is a great privilege for Split to be involved in a project like Science Comes to Town, which is the first of its kind in the European Union," Šepić says. As for encouraging new generations of scientists, “This is a great effort, and I hope that we will see an effect in a few years.”Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Falcons’ Tua Tagovailoa Faces Uncertain Future After Andy Dalton Signing
The Atlanta Falcons made a pair of quarterback roster moves on Monday. No, neither of them directly involved Tua Tagovailoa, Atlanta’s current backup QB. The fact that the moves happened at all, though, raised questions about Tua’s future with the Falcons. Falcons QB Moves The Falcons chose to sign free agent QB Andy Dalton, the […] The post Falcons’ Tua Tagovailoa Faces Uncertain Future After Andy Dalton Signing appeared first on HEAVY.
NBA tells sportsbooks to ban certain bets and parlays: report
The NBA told sportsbook partners in a Friday memo to ban certain types of bets and parlays this season that gamblers used in recent wagering scandals, ESPN reported."There's a balance between ensuring that we are removing problematic bet types but also ensuring that we don't just move activity into the illegal market," NBA executive vice president Scott Kaufman-Ross told ESPN. "Where we landed right now, we think, is the right balance of those two objectives."
Liverpool Reportedly Out: Chelsea Target ‘Dead Set’ on Joining Blues
Despite it being October, the transfer mill never truly stops spinning with clubs seemingly already lining up their business for January and beyond. Liverpool have started their season under Andoni Iraola fairly well, new reports indicate they won't look to strengthen certain areas in the winter window, which could open the door for Chelsea to …
Connor Hellebuyck Traded By Winnipeg Jets in Blockbuster Deal
Connor Hellebuyck has reportedly been traded from the Winnipeg Jets to the New Jersey Devils, ending months of uncertainty surrounding the superstar goalie.
How well have past GOTY winners sold?
We’re less than two months away from 2026’s The Game Awards, and what a year it’s been for fantastic games, including Resident Evil Requiem, Forza Horizon 6, Slay the Spire II, the Blood of Dawnwalker, and Control Resonant – just to name a few. So as we approach the end of the year, we thought we’d look back on our estimates for the GOTY winners of the past four years. In terms of revenue, Elden Ring (2022 winner), Baldur’s Gate 3 (2023), Astro Bot (2024), and Expedition 33 (2025) have generated a combined $3.8B via 73M copies sold: Let’s have a look, then. Elden Ring has generated $2B in revenue Elden Ring is a phenomenon in every sense. It’s sold a whopping 36.4M copies across Steam (50%), PS5 (35%), and Xbox (15% across console and PC). Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring also just passed an astronomical milestone: $2B in revenue. While PlayStation and Xbox account for half of Elden Ring’s copies sold across these three platforms, they account for 57.5% of revenue. This – as ever – is due to regional pricing and the higher relative share of PC gamers in lower-priced markets. For example, around 17.4% of Elden Ring’s Steam copies sold were in China, where the game costs about 26% less than the price in the States. There’s an … interesting narrative going around these days that console gamers are only interested in ball-and-gun games and have the patience for little else. Well, Elden Ring’s impressive sales prove that is simply not true, and across all platforms. What’s more, over 9.8M people have played Elden Ring for over 100 hours, with nearly 3.5M people getting all of the achievements and trophies. For reference, 10.9% of Elden Ring’s PlayStation players have the platinum trophy, while 10.5% of players on Steam and 3.9% of Xbox players unlocked all the achievements. Git gud, Xbox players! Of the 1.5M people who played Elden Ring on PlayStation last month, 4% also played Dark Souls 3 last month, 4% played Bloodborne, and 3% played Sekiro. There’s those Soulsborne diehards for you. By many accounts, including my own, Elden Ring is one of the best games of all time. It’s an evergreen seller that will continue to be a cash cow for Bandai and FromSoftware for years to come. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring has sold another 2M copies across Steam, PlayStation, and Xbox this year, generating almost $110M. This means it’s outperforming many of this year’s high-profile releases. Even Elden Ring’s standalone run-based PvE spinoff, 2025’s Nightreign, has sold 7.8M copies and generated $282M in revenue. Baldur’s Gate 3 is another billion-dollar-plus banger Another cross-platform phenomenon is Baldur’s Gate 3, which has sold 23.2M copies and generated over $1.2B in revenue. About 18.7M of these copies (80.6%) are via Steam, 2.9M via PS5 (12.7%), and 1.6M (6.8%) via Xbox. Around 1.3M folks on Steam bought BG3 before it hit 1.0. The PlayStation version launched about a month after the PC 1.0 release, while the Xbox version came four months later due to technical issues around developing local co-op on the Series S. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Across platforms, Baldur’s Gate 3’s monthly active users have never dropped below 2M, including 2.2M MAUs last month (68.5% on Steam, 21.9% on PS5, and 9.6% on Xbox). And it still regularly brings in 280K to 400K players every day: About 1% of BG3’s Steam player base has played for over 500 hours! That’s a little under 200K people. Astro Bot is also an evergreen seller, albeit a more niche, family one Astro Bot, 2024’s winner, has now sold 4.7M copies and generated $291M in revenue. The budget, including marketing, is almost certainly under $100M, given the small Japan-based core team and three-year dev timeline. You can really see why the tides are changing toward less expensive hubs. Astro Bot is the only first-party winner on this list, but follows other first-party winners of The Last of Us Part II (2020’s winner), God of War (2018), and Breath of the Wild (2017). Around 46.6% of Astro Bot’s copies sold have been physical, which is far higher than the typical game. This makes sense for a couple of reasons: There’s a large family audience for this one, and physical boxes are an item to wrap when giving Astro as a gift. Astro has collector value for the PlayStation core (this is nostalgia-fueled platformer celebrating PlayStation’s history) Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Astro is another one of those games that continues selling over time, regularly selling more than 100K a month. It’s sold around 1M more copies this year ($60M in revenue) and is a popular title with families. We can see this using the Alinea platform’s MAU crossover tool: Astro Bot’s top #2, #3, and #4 games by crossover in any given month this year are Minecraft, Fortnite, and Roblox – without fail. The #1 title every month, though, is Astro’s Playroom, a pack-in with all PS5 consoles. For every month this year, between 20% and 30% of Astro Bot players also played Astro’s Playroom that month. So the free pack-in is a noice funnel for converting players to a full paid product. Expedition 33 sells 8.7M despite Game Pass cannibalisation Finally, we have last year’s winner – Expedition 33. The turn-based-RPG banger has generated $366M via 8.7M copies sold, with 58.8% on Steam, 35.7% on PS5, and 5.5% on Xbox. Xbox’s share of copies sold is this low due to Expedition 33 launching on Game Pass, where 4.3M people across console and PC accessed the game. A little under 700K Xbox players used their subscription to play Expedition 33 this year. That said, the game’s 1.5-year Game Pass deal ended last week on October 16, and we’re already beginning to see a positive trend on Expedition 33’s copies sold via Xbox (but the jury’s still out!). There’s understandably a lot of French pride behind this one, as France is the game’s #3 market on both Steam and PlayStation. Vive la France! One thing that stood out to me is that the GOTY winners aren’t $300M Hollywood productions made in the US. They’re mostly mid-budget studios outside the traditional AAA cost centres. Lots to think about there. Also, good games sell well; who’d have thunk it!? And there’s a whole load of them this year, with GTA 6 still to come, too. GTA just made the cutoff point for the VGAs this year. What a coincidence! Loading... Cool links and other stuff Our physical games newsletter from Tuesday was picked up by GameSpot, Eurogamer, TweakTown, and a bunch of others. We’re offering a free trial of our platform for games companies. Send us a message here, or reply right here on Substack/email, and we’ll set you up. Next week, we’ve got some exciting news regarding the future of our newsletter, so stay tuned! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. Want to see why these companies (and many others) are subscribed to Alinea? Get a free platform trial! [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Mad about Science: Doppelgängers and weird coincidences » Sandpoint Reader
By Brenden BobbyReader Staff History is full of weird coincidences. Enough people exist for a certain length of time and you are bound to have some expected, albeit unusual, occurrences. It’s just statistics at...
Donald Trump claims ‘Iran war will end very soon’ as midterm rallies heat up
The US president said that the war will end ‘as soon as I want it to end’ as the midterms take place under a cloud of economic uncertainty
Too much RNA can starve cells of energy, scientists discover
Scientists have uncovered an unexpected danger lurking inside cells: too much RNA can damage the structures responsible for producing energy. A new study found that excess RNA, including the normally essential messenger RNA (mRNA), can directly disrupt mitochondria without relying on the immune system. The discovery could help explain how viral infections and certain aging-related diseases damage cells.
NBA bans certain types of sports bets following high-profile gambling scandals involving players
The NBA is banning certain player prop parlays and other wagers while expanding measures to detect suspicious betting activity and protect players from harassment.
Peoria businesses face dilemma at plaza owned by healthcare giant
The sale of MidTown Shopping Plaza to OSF HealthCare has left local business owners on edge. It has led to uncertainty, stalled investments and tenants bracing to start over elsewhere.
I’m a vote for ‘none of them’
I have voted in every election since I turned 18. Except when a race was uncontested, I have always filled out the entire ballot. Not this year. For the first time, I’m leaving an office blank. Let me begin by congratulating Phil Weiser on becoming Colorado’s next governor. Yes, it’s a certainty. Even if they […]
Exclusive: Donors fear the worst for Kennedy Center’s art amid renovations uncertainty
At the height of legal and political tumult at the Kennedy Center last summer, board members discussed moving the iconic eight-foot, 3,000-pound bronze bust of President John F. Kennedy from the Grand Foyer while the main building closed for renovations.
Dignity Health nurse navigator, breast cancer survivor shares advice for women with cancer diagnoses
A breast cancer diagnosis can bring uncertainty and questions about what comes next, but patients don’t have to navigate that journey alone. Tana Toll, a breast cancer survivor and nurse navigator with Dignity Health, joined KCRA 3 to talk about resources that are available.
Forgotten record review: Painless jazz
Jazz is a niche market, and the folks who love jazz really love jazz. Their passion, and the cult-like nature of jazz, has given rise to a certain snobbery regarding jazz music. That snobbery is limited almost exclusively to the years 1947-1967.
Why this Glendale business owner is suing the U.S. government
Mario Ayala said he is trying to keep the business running, but the uncertainty and damage from the raid has taken a toll. Zach Prelutsky reports.
Baidu (BIDU) Expands Its AI Business, but the Core Revenue Recovery Remains Uncertain
Baidu, Inc. (NASDAQ:BIDU) is expanding autonomous driving and AI services while its traditional business stays under pressure. That raises a hard valuation question: can the new activities grow fast enough, and profitably enough, to replace what the established business is losing? At roughly 19 times forward earnings, investors pay for that transition to work. They […]
This week in health care policy: October 16–23, 2026
Medical innovation FDA approves several innovative treatments. Last week, the FDA granted accelerated approval to GSK’s Jemperli for certain untreated cancers with a specific DNA defect. The treatment will eliminate the need for costly alternative treatments such as surgery, radiation, or chemotherapy, which are known to cause lasting health problems. The FDA also approved GSK’s […]
Why this Glendale business owner is suing the U.S. government
Mario Ayala said he is trying to keep the business running, but the uncertainty and damage from the raid has taken a toll. Zach Prelutsky reports.
Likelihood Each Cubs Free Agent Starter Returns
From Shota Imanaga’s uncertain future to Clay Holmes’ defensive fit, we breakdown the odds of Chicago’s veteran rotation arms returning to the North Side for 2027.
Funding the Future: What Gives CFOs the Confidence to Grow
PYMNTS Intelligence explores how business uncertainty affects CFO spending plans and what could give companies the confidence to invest.
Sun Prairie considers new massage business regulations after police receive complaints
Sun Prairie leaders are considering new regulations for massage establishments following complaints to police about activity at certain businesses.
An Uncertain Landscape for Science Funding (opinion)
New obstacles for early-career researchers could undermine U.S. innovation and competitiveness in the long term.
Shohei Ohtani's health and possible lockout loom over uncertain offseason for Dodgers
After their earliest postseason exit in three years, the Los Angeles Dodgers head into the offseason facing uncertainty over next year.
Uncertainty Over Pope’s Health Fuels Familiar Debate Over Vatican’s Candor
By announcing his lung condition himself, Leo has been more forthcoming than many popes. But mysteries remain, prompting scrutiny of papal statements for hidden meaning.
SnakePit Post-season GDT, #19
The Brewers successfully held serve in the World Series opener, though it certainly got a bit tense there in the ninth inning, as Tampa had the tying run in scoring position with one out. It ended up as the 11th one-run game this post-season. That’s still a long way off the MLB postseason record for […]
Why this Glendale business owner is suing the U.S. government
Mario Ayala said he is trying to keep the business running, but the uncertainty and damage from the raid has taken a toll. Zach Prelutsky reports.
Bowl Games Face Uncertain Future With a 24-Team CFP
College football bowl game viewership rose 13% year-over-year in 2025.
Microsoft AI CEO says new model beats OpenAI using less compute
Microsoft AI CEO said its latest AI model outperforms an OpenAI base model on certain pre-training metrics using a quarter of the compute.
Raiders’ Ashton Jeanty Comments on Health Before Bills Matchup
Raiders running back Ashton Jeanty provided an update on how he's feeling amid uncertainty over his availability for the Bills matchup. The post Raiders’ Ashton Jeanty Comments on Health Before Bills Matchup appeared first on HEAVY.
When computer science meets the alpaca immune system
After earning bachelor's and Ph.D. degrees in bioengineering with a focus on molecular biology, Will White, a postdoctoral scholar in the Department of Computer Science at Tufts, was pretty certain his ...
NBA, sportsbooks reportedly agree to ban certain bets, including parlays involving the under on same player's stats
Catapult Books is being sold and its L.A. authors are mourning
Catapult Books has sold its assets to an undisclosed buyer, leaving the future of 16 scheduled titles uncertain as staff negotiate a severance package.
JD Vance is happy to tell you about his Machiavellian politics
Americans have become familiar with Machiavellian politics during the Donald Trump era. The president is certainly a practitioner. Vice President JD Vance is cut from the same cloth.
1 player Eagles must target at 2026 NFL trade deadline
If the Philadelphia Eagles make any more trades before the 2026 trade deadline , it should almost certainly be as sellers, not buyers. Now sure, could Roseman find a bargain on the margins and make a move, like if a team is willing to take a conditional seventh-round pick for a player at a position of need – safety, anyone? -instead of releasing […] The post 1 player Eagles must target at 2026 NFL trade deadline appeared first on ClutchPoints.
'World Class' - Celtic Player Solution to Martin O'Neill's Problems
The Celtic player has one 'world class' attribute that will remind fans of a certain Kyogo Furuhashi.
MLB Qualifying Offer Figure Rises Amid Labor Strife
An uncertain offseason for MLB is quickly approaching.
This mysterious mushroom makes people see hundreds of tiny humans
For nearly a century, people in distant parts of the world have reported a bizarre experience after eating certain wild mushrooms: seeing dozens or even hundreds of tiny, colorful humans moving through the real world. Now, scientists have identified a mushroom species, Lanmaoa asiatica, responsible for these extraordinary hallucinations in China and the Philippines.
New York Yankees’ Insider Unveils Latest Giancarlo Stanton Situation
The New York Yankees are facing uncertainty with Giancarlo Stanton.The 36-year-old slugger is a loyal veteran, but the Yankees’ crowded roster has been pushing him off the table.According to an MLB insider, here’s where things stand for both parties.Yankees’ Looming Giancarlo Stanton Decision Weighs HeavilyAs detailed by Brendan Kuty of The Athletic on Oct. 14, […] The post New York Yankees’ Insider Unveils Latest Giancarlo Stanton Situation appeared first on HEAVY.
USC women’s basketball ranked No. 3 in preseason AP Poll
Expectations are certainly very high for the Women of Troy this season, as evidenced by their preseason ranking
LeBron James Lands on 76ers' Injury Report Ahead of Bucks Game
LeBron James' status remains uncertain as the undefeated Philadelphia 76ers face a rebuilding Milwaukee squad. This could force Tyrese Maxey and a struggling bench to step up in his absence.
Former Oregon QB Bo Nix Faces Uncertain Future With Broncos
Lingering injuries and a mid-season offensive shift have stalled the former first-round pick's momentum, forcing Denver to weigh his long-term potential against a massive looming contract extension.
Study finds health care provider photos in waiting rooms can strengthen patient trust
A new Florida State University study finds that adding health care providers' photographs to clinic welcome signs can strengthen certain aspects of patient trust before patients even meet their providers.
STC Honors Inaugural Staff of the Year Recipient
Norine Bardo joined the South Texas College team in 2020, amid a global pandemic, when everyday life was uncertain. Over the years, the one thing that remained steadfast was her dedication and commitment to the college, earning her the inaugural 2026 Staff of the Year Award for Pecan campus.
Study shows link between Alzheimer’s disease and gut health
Researchers found that people with higher levels of imidazole propionate (ImP), a compound produced by certain gut microbes, were more likely to show signs of Alzheimer’s disease.
PFAS in Agriculture: Science, Uncertainty, and Risk Communication
Summary PFAS contamination raises legitimate health and environmental concerns, but this diverse family of thousands of chemicals should not be treated as
FSU study finds healthcare provider photos in waiting rooms can strengthen patient trust
A new Florida State University study finds that adding healthcare providers' photographs to clinic welcome signs can strengthen certain aspects of patient
How the brain handles uncertainty, and why resilience matters
The science of handling uncertainty, anxiety and stress
Marlins Could Target Veteran Free Agent Due to New CBA
With a salary floor almost certain for next season, Miami should make an offer to Ian Happ
Austin Hedges’ Future With the Guardians Appears Uncertain
Austin Hedges has been an important piece of the Cleveland Guardians roster for the last half-decade, but there's no guarantee he's back in 2027.
Cardinals’ Jeremiyah Love Faces Uncertainty After Latest Injury Update
The Arizona Cardinals may be shorthanded once again at the running back position, with rookie Jeremiyah Love battling an injury. The post Cardinals’ Jeremiyah Love Faces Uncertainty After Latest Injury Update appeared first on HEAVY.
“There certainly is a capacity that you need to have …
“There certainly is a capacity that you need to have …
Ashwagandha Promises Calm. The Science Is More Complicated
The popular supplement may help ease stress, but evidence for anxiety remains uncertain–and rare side effects complicate its soothing reputation.
Lisandro Martínez's future at Manchester United uncertain after board criticism
Manchester United currently occupies 13th place in the Premier League with six points from six matches, having won only two of nine games this season.This decline in form, which includes a five-game ...
Sundar Pichai: Google’s Frontier Imperative, Compute Scarcity Dilemmas, Future AI Products and Businesses
Alphabet CEO Sundar Pichai has little patience for doubts about Google’s willingness or capacity to compete at the frontier of AI. His company’s latest Gemini 4 Argon model — long-promised and recently delivered — beats OpenAI and Anthropic’s latest public models on coding, math, science, and knowledge-work benchmarks and has placed Google’s AI back among the world’s best. Amid chatter that Google was fine with good-enough lightweight ‘Flash’ models, Pichai pushed back hard against any suggestion that company is limiting its research ambitions. “We won’t do it any other way,” he told me in a Big Technology Podcast interview recorded this week at Google’s Mountain View headquarters. Pursuing cutting-edge research is costly for Google, requiring compute and chips that otherwise could be sold at a high markup by its cloud business. But Pichai said allocating resources to frontier AI development is “ground zero” for Google. “Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development,” Pichai told me. In our conversation, we discussed Argon (which Pichai says processed three times as many tokens as Gemini 3 in the 72 hours after launch), AI’s role in developing better models, the AI interface of the future, competition with OpenAI, Google’s partnerships with Anthropic and Apple, data centers in space, and the nature of his optimism. You can read the full conversation, lightly edited for length and clarity, below, or listen to it on Apple Podcasts, Spotify, YouTube, or your podcast app of choice. Alex Kantrowitz: Google is back at the frontier with Gemini 4 Argon, which beats OpenAI’s and Anthropic’s public models on benchmarks spanning coding, math, science, and knowledge work. The conventional wisdom was that Google had given up on the frontier to focus on fast, good-enough models for its products. That was wrong? Sundar Pichai: Very wrong. Look, we are so committed to being at the frontier. It’s in our DNA. We won’t do it any other way. We’ve been thinking about the AI frontier for well over a decade now. The frontier is very dynamic. It’s very competitive. It’s very exciting. I couldn’t be more pleased with how Argon has come together. We took our time with it. We made sure we tested it safely and deployed it carefully. We took a bit longer than our other models, given its capabilities. Across the board, be it for agentic work, knowledge work, coding, creative tasks, Argon is one of the really good frontier models. The first 72 hours since we launched, it’s almost up to 25 trillion tokens used, which is about three times what Gemini 3.0 had in the first 72 hours. And we are capacity constrained as we are serving it. Excited, but there are always areas….. You know, the frontier is very dynamic, and you have to keep evolving the models. There are areas which we can see we need to improve as well. We’ll be at work on all of that as well. Which areas? On any given model, Argon would be across the board better at everything if you just look even two months back. But the space is so evolving. Even on coding, for example, there are pockets where we know we need to do better, and there’s clear feedback. We’ll make it better. The argument for standard models is that they’re already good enough to build great products, with the frontier valuable only for certain tasks. Meta built Muse with good models rather than the best, and Google could put standard models into Maps, Gmail, and Search. Why isn’t that sufficient? It’s definitely not how I have thought about it at all. We are deeply committed to driving the state of the art and actually pushing where this technology can go, all the way from transformers. That’s a journey we’ve been on. You will see us continue to do that. When you’re at the frontier, you get an earlier look into the emerging capabilities, earlier than others, which helps you better prepare for the future. We are fortunate to have a wide set of opportunities across consumer and enterprise. Some of our cloud customers, for sure, want the model at the frontier. The frontier models will be better at developing the next set of models in an era of recursive self-improvement. I would argue it matters there. Internally, we have definitely seen a steep point of inflection by deploying Argon to our developers. It definitely tackles problems which our previous models could not do. Being at the frontier puts you at the innovation frontier and helps you drive that as well. There is room for models of all sizes and capabilities. That’s why we did Flash, Flash-Lite, etc. I agree with you that you can develop very good product experiences with not necessarily the most frontier model, because they tend to be slower and more expensive too. But we care about the Pareto frontier, and we’re committed to doing all of that. You said developing frontier models gives you a look at what’s coming. What do you see on the horizon? What makes this moment so exciting is you build something which you think is a culmination of months of work, and you put it out. You already see clear headroom ahead. We’ve all been working on these agentic, long-horizon capabilities, but clearly the frontier is going to have multiple of these agents working together to do things. That’s an example of an exciting paradigm underway. It’s also clear to me that users, both in consumer and enterprise, will have access to some multi-agent framework for them, working all the time doing things. It feels like a moment of infinite possibilities. Sergey Brin said one of Argon’s core innovations was relying more on the model to help develop the model. Yet incidents involving OpenAI’s bots breaking containment and Google’s bots accessing a site they shouldn’t have suggest these systems still aren’t perfectly aligned. Isn’t there reasonable cause for concern about accelerating toward recursive self-improvement? There are three parts to your question. Let’s first talk about RSI itself. You’re right, Sergey mentioned RSI being a critical contributor as we are developing Argon. But to be very clear, today, in a continuum, we are pretty far from the end state of RSI or something like that. The right way to describe it is you have RSI loops along with AI researchers in various aspects of model development. You almost have agents helping AI researchers in some automated way work together to build these models. It’s good to at least understand where we are today, and it’s super exciting. I expect that continuum to keep making progress as we go into next year. The second question is around safety. Security comes from defense in depth. You’re talking about alignment, obviously. We all are doing a lot of work to make sure the models are as aligned as possible. But it’s an active area of research, and there are clear gaps. That’s not the only thing we rely on. You have the work you do on alignment, but beyond that, we put a lot of effort into real-time monitoring as these models are working. Making sure you have good telemetry into what’s happening so that you can intervene in real time if you see unexpected behaviors. How you do that, the architecture with which you do that, how you make sure it’s all sandboxed and isolated in a way that it can continue doing its job during real-time monitoring — these are all areas of investment. Obviously, when we deploy these models, giving customers, enterprises, control, both with real-time monitoring, but their ability to decide where they deploy, what type of data which models ever have access to, etc. All that work is very, very important, and we are doing a lot of that. As an industry, we need to constantly up our game and take the time to do all this stuff, including dedicating the compute required to make sure you can safely deploy these models. The third part is: Is it all enough? This is why there are a lot of conversations in the industry, and I think it’s reasonable to be worried. The right way to approach something you worry about is early on thinking about what more we can do. As an industry, you’re definitely seeing increased levels of work on alignment, testing for safety, etc., as we deploy these models. The next step would be developing better standards so there are cross-industry standards of how we do these things, including the ability to evaluate using independent evaluators. If you look at areas like financial controls, we have accounting standards, we have independent auditors. Those are all the next natural steps for us as an industry to work toward, and regulation will end up playing a role as we go through all of that as well. Google pursues both language models and world models, while some other AI companies like OpenAI have focused more heavily on LLMs as the path to AGI. Why is world-model research important to you? As humans, you obviously perceive the world around you, and you’re taking all those inputs. Making sure these models are able to understand the laws of physics, simulate the world in high fidelity. All that, I think, are key enabling blocks for intelligence. We are working across all possible applications of this. Take an area like robotics. It’s not an accident: If you look at embodied reasoning benchmarks, Argon is state of the art. That all comes from our experience building world models. Inherently, I would expect there will be architectures which will converge all of this in the future. But for us, we view this as, today, this jagged frontier that is intelligence. We want to be at the frontier of all the possible approaches, and that will help us both drive better research, better insights, and develop a much better AGI model, is how we think about it. Some people argue Google should focus on selling its computing resources rather than using them for AI research. Cloud wants to sell compute at a high markup, while researchers need a very big computer to build the best models. How do you balance those demands? Ground zero for us is making sure we are investing in the compute that’s needed to be at the AI frontier. In 2015, I set the company to be AI-first. AI is that key horizontal ingredient across everything we do, all the way from Search to Cloud to Waymo. That is ground zero for us, making sure both for research and developing the models that we have enough compute needed. Beyond that, we have these independent businesses which each have their own long-range plans. They’re using those long-range plans to project forward, and we plan for compute for all of them. The cloud team, they have a business and they have a projection and they have demand signals. They have committed contracts. With that help, we can plan on a long-term compute trajectory for them. We’re fortunate to have this wide set of opportunities. There’s no company in the world which isn’t making trade-offs at any given moment in time. But the first principles we operate on is making sure we have enough compute to invest in the frontier, and that’s non-negotiable, and everything else works on top. Remember, we are building our own compute, our own data centers. There are long lead times. The compute we have today is a function of decisions I made in 2024. Even if you think back to a year from today, last year the agentic coding takeoff hadn’t happened. Today, obviously, when you sit and look at anything, everyone is short—not just us, other companies—and everyone wishes you had two times what you had planned for. That comes with the territory. At any given moment in time, we are planning for what we would need two to three years out in the future. You’re going to find some decisions you make may look suboptimal two years out, depending on where the state of the art is. I don’t spend too much time thinking about it. The way I think about compute allocation is making sure Google DeepMind, both for research and frontier model development, is cutting edge in terms of compute access. After that, we plan for all our businesses. It’s great we can provide our compute to other people too, like we have done. It allows us to scale that up, get real tests for it in the widest application set possible, test it in the real world, and make sure we are at the cutting edge of technology at every layer of our AI stack as well. Ben Horowitz relayed on a podcast that Andy Jassy had said compute was sold out until 2028. Are you seeing the same thing? If today a customer is coming out and asking us for compute in ’27, that is incredibly difficult to do. Even last year we went out and leased some short-term compute to accommodate some customers and help them out. But yes, we are all dealing with similar timelines. Every major technology shift seems to involve overbuilding, from railroads to fiber. Do you think that’s happening here? It depends on the time frames you’re looking at. This level of build, if I take a long enough time frame, it makes complete sense to me. We are at early stages of the most consequential technology ever, and this is not like fiber. It’s not dark. We are using it. We are capacity constrained on a daily basis. The applications, the underlying technology is improving rapidly. But running a company, the way I work through the moment is you look at your demand signals. You look at your committed revenue opportunities that you’re getting in the form of contracts. You balance that with the underlying technical capability, or internally you balance how we are using it internally, the model trajectories. Based on all that, you take a disciplined approach—a confident, aggressive, but disciplined approach—to plan out compute. But when you talk about the broader economy as a whole, you’re having people operate with various levels of risk. I focus on what I can control as a company and plan through it. If your question is, can there be an overbuild? Yes, because you can have some constrained components. Remember, what matters is a set of everything you need to build out that compute. Memory, electricity, electricians…. Land. Like 2,000 components or more. You could get constrained at some point. There could be things which cause bottlenecks, and then you could have overbuilds. There could be external shocks to the economy. There are macro risks. All that is possible at any given time. But am I confident that the compute we are planning for, we will have uses for it given enough time? Absolutely, yes. I was in the room when you said AI would be as profound as fire and electricity. If you believe that, shouldn’t you give researchers the biggest possible computer, even at the expense of today’s cloud profits? We’re all doing some form of that. Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development. What you’re seeing is true already. But you want to be thoughtful. Even our AI researchers have some constraints, which are also good. That’s what inspires creativity. That’s what helps you come up with a more efficient algorithmic breakthrough, maybe to use less memory. What we are committed to is to invest what’s needed to stay at the frontier. OpenAI President Greg Brockman told me a few months ago that the ideal AI product might have no interface at all—just as natural as conversation. What do you think the interface looks like in the age of AI? Computing historically has been humans adapting to computing. With AI, it’ll be the other way around. The technology will adapt seamlessly to how humans live and go about their day-to-day life. You want to be able to speak to that AI when you want to. It has context. It can be persistently running somewhere, give you continuity. You’re not dealing with a lot of complexity. It’s natural. All that makes sense to me. That doesn’t mean it won’t have any interface, however. Nowadays, even on my phone, Gemini voice models are so good. I can just press the microphone button. I can just ramble. That’s why we call it Rambler. I can ramble. It intelligently corrects with my personal context. Even my friends’ names, weird names, it gets it right, even if it first guesses it wrong. It’s amazing. I’m not going in, backspacing, editing once I finish saying it. It’s remarkable how good it’s gotten. But there are going to be moments you will need an interface. You may want to entertain yourself. You may want to watch a video. You may ask your AI to create something, and you want to watch it, consume it. The way I think about it is, you want it to be as seamless and as natural as possible, and that you are not doing the hard work adapting to whatever the interface is. The technology is adapting to how you’re working at any given moment in time. When I asked Sam Altman about competition from Google, he argued that OpenAI was building AI-native products and implied Google was bolting AI onto existing ones. Do you accept that framing, and can a “bolt-on” compete with an AI-native product? First of all, it’s a very dynamic moment. We are all pushing each other. OpenAI has pushed us as a company too. This is not just we are doing something to them. Far from it. Yes, Google went into its own version of a code red too. In the AI moment, all of us have to respond with varying levels of urgency at any given moment in time. We are constantly building new products as well. Gemini was built from the ground up as a product—the Gemini app I’m talking about. Or tomorrow, as all of us are adapting to agents, are you bolting agents onto ChatGPT, or are they building it natively? How would you think about that? You can always put these questions back. I don’t think of it that way. I think of it as you want to build world-class product experiences that are AI-native and they are winning. Some of it is adapting products, some of it is rethinking new experiences. They will all be part of how you approach this moment. How do you expect to make money from these AI interfaces? If an agent recommends a product and I buy it, should it take a cut of the sale, even if that’s disclosed? I’m going to put enterprise aside. Consumers are going to increasingly value this technology. Take software developers today. Developers are willing to pay for these coding models because it really helps make them more productive. Nobody would want to code the way they were coding three years ago, or even the same time last year. When you’re delivering value, there’s value to be had. I’ve never seen examples where consumer products really scale to billions of users, where people are using it intensely, and haven’t had monetization to go along with it. If you’re providing value to people, there is inherent value to be had. The nature of it may change. You’re asking a scenario in which agents are doing stuff for you. At the end of the day, you will have commercial needs. The agents need to fulfill those commercial needs. The providers on the other side are going to see value in that. There’s going to be some mechanism by which it gets fleshed out. That’s what an efficient system does. But what matters is that you’re building those world-class consumer experiences. I promised myself one product feature request: Can you make Gemini-powered search in Gmail as good as searching Gmail through ChatGPT? What’s going on here? One of the exciting things we announced recently is the unified Gemini agent for enterprise, and we’re bringing that to consumers. These are persistent agents which run 24/7 in the cloud. We’re spinning up a micro VM effectively for every query, and from the runtime, the harness, the model—it’s all a headless service. It’ll work everywhere, and it has your context with you. You can address this agent whether you’re in Workspace, in Search, in Gemini. Agents are going to drive this unification from a customer experience, which people are looking for. When you have a broad product portfolio and you’re moving forward fast, there are always areas where you’re moving forward faster than some other areas. That’s valid feedback. But we are putting a lot of time and effort into making sure, as we build out our agentic experience, that unification and that capability works well across all these services. People have asked where Google’s equivalent of Muse or Dots is. Do you anticipate creating a new product to compete with them? Our goal with Gemini is to be a personal, proactive, and powerful assistant. That’s what we are working toward. You saw us describe the early versions of it at Google I/O this year with Spark. Effectively, already, if you open the Gemini app as a Pro or an Ultra user, you see Chat and Task, and they start giving you that agentic experience. With Argon now, that capability is dramatically accelerated. What we announced recently in our enterprise event, we are bringing that to consumers as well. Soon in Gemini, you will be able to ask something, and it’s a continuum. You don’t need to think about whether you’re asking a chat or an agentic task. It’ll just automatically do the right thing, and it can work persistently in the background securely and get things done for you. Already, empirically, when I look at what’s coming into Gemini in our app, last year you would have tagged them and most of them would have been chats. But a steadily growing percentage is already agentic tasks in Gemini. Yes, we are going to bring personal agents to our consumers. It’ll work in the Gemini app. It’ll work in Google Search. It’ll work in Gmail. You can address it, call it, etc. We want to make sure we’re getting it right. It’ll be powered by Argon, and we are very excited to bring it to our users. Google has invested and committed tens of billions of dollars to Anthropic. What do you see in Dario Amodei that makes you want such a deep investment and partnership? Very early on, when we looked at the founding team of Anthropic, it was very clear to us this was a world-class team which was involved in some of the earliest GPT models. We were quickly able to assess that they would be at the frontier. We’ve always tried to identify and partner with companies which would be at the cutting edge of technology. We’ve done that with SpaceX. We’ve done that with Anthropic. That’s what we saw, and we had a chance to partner. Is your partnership with Apple to license Gemini for Siri expanding, contracting, or standing still? For both us and Apple, that partnership was about translating the capabilities of AI into better experiences for users. I thought Apple has done a phenomenal job of incorporating—they customize these models and build it into Siri—and it’s been great to see the reception. We are committed to doing more. You’re going to do more with them? There’s nothing specific to comment, but it’s a partnership. It’s working well. What have you learned so far about the feasibility of data centers in space? It’s a very exciting project. Projects like this remind me—I still recall that moment in the desert for the DARPA Grand Challenge, watching the Stanley car compete in it, which ended up being the basis for Waymo. With all these technologies, you’re at a moment in time where it looks a bit like sci-fi, but 10 to 20 years down the line, it’s actually working in a meaningful way. I feel the same in space. We’ve always believed in betting big on these technologies. Quantum has been a great example of it. We’re probably 10 years into the journey. Waymo, we are almost 20 years into the journey. Space, we are two to three years into the journey. It’s clear to me that it’s an approach which will make a lot of sense in the future. Being in sub-synchronous orbits with 24/7 access to the most abundant form of energy we have access to will make a lot of sense for this exponential increase in compute that we are going to need. Having said that, this is a challenging project. The team has disciplined milestones. It was a super exciting milestone to send the TPUs up to space. Sometime, as we are speaking, we are expecting a “hello world” moment from them. I look forward to seeing that happen, and we’ll continue investing here too. You previously said 25% of the code written within Google was written by AI. What’s the number today? That number in our world today is meaningless in the sense that every part of what we now touch is influenced by AI deeply. What we are tracking with Argon, for example, it’s been a point of inflection. People are using Argon to really go tackle complex projects, including projects which affect millions of lines of code. In the four weeks since we have launched Argon, we have seen a 30% increase in CLs, and more importantly, almost a similar increase—a one-third decrease in rollbacks. People are writing code more productively and better code with it. We are tracking it with newer metrics now. How are you dealing with opposition to data centers? If you can’t build in the U.S. the way you want to, where else do you go? We’re very committed to building our data centers very responsibly. When I look at our largest data centers in some of the communities where we have been the longest, I visit them, I talk to people. There are people who come and tell us their kids have gone to college because of our investments in these communities, and we’ve grown in those communities. To me, this is about doing it right. Engaging with the communities early, doing it transparently. We are committed to making sure we are bringing incremental power, and we cover 100% of the cost of our power needs for these projects. It’s understanding the impact on neighborhoods and making sure you’re working thoroughly to address them. Done rightly, you can continue making progress. But we are constantly taking feedback into account. I do worry not everyone operates the same way. People have been surprised by data centers showing up in their backyard. Those are all important. As an industry, we should continue to do better. But part of the reason, in a 20-year time frame, we are thinking about things like data centers in space is making sure we are able to put these data centers where maybe the trade-offs will be different. What unproven area of AI is Google working hardest to crack? Is it continual learning—getting models to keep updating after release—or something else? There are multiple parallel paths. You saw with Argon we have a million output tokens. With our Gemini models early on, we had a one-million context window on the input side. These are all examples of breakthroughs we are constantly working on. How do you think about synthetic data? How do you think about continual learning? How do you think about more efficient architectures? We do dedicate a meaningful percentage of our compute to these research bets too. It always goes hand in hand, including our world models. Those are all bets we are placing. Sometimes, as part of these bets, there are ideas that emerge which just make their way into the mainline models. Maybe we don’t fully talk about it, but we have multiple steps in these areas. Working in technology requires optimism that building something will improve the world, but those bets can leave real consequences when they fail. I recently returned to a town in El Salvador where enthusiasm for Bitcoin had given way to unfinished construction and something resembling a ghost town. How do you maintain the optimism you spoke about in your Stanford commencement address while accounting for those risks? I genuinely have a deep conviction that improving technology and improving access to technology makes people’s lives better. It’s been my personal experience in my life, out of which comes that deep conviction, optimism. But with that, I’ve always felt humanity’s journey is always about working hard to harness that technology to make it work well for society. The optimism is not an optimism that you just build whatever you want, whenever. You work hard to make sure you’re building technology in the service of humanity, to make the human condition better. That’s got to be the defining goal as we are approaching it. With that framework, I’m very, very optimistic. We are in very early stages of the kind of progress that we are going to see on many areas. We’re all talking about areas like healthcare. A lot of the progress is ahead. The ability to make things in a fundamentally cheaper way on many things where things have been getting expensive for a long, long time, discovering new materials, etc., which really bend the curve—it’s tough to step today and understand the impact of all that, but they’re going to be very profound. I’m very optimistic, but we have to be rightfully concerned about all the ways this technology can go wrong. Sundar, I know you don’t do many of these. Thank you. Thanks, Alex. Appreciate it.
Birth centers are linked to better health outcomes, research shows, but 10 states have none
Birth centers are an option for those with low-risk pregnancies and are correlated with more positive health outcomes, but 10 states do not have any birth centers at all, and more could be built with certain state policy solutions and different models of care, a new report suggests.
Eagles: Jalen Hurts' Future in Philadelphia Questioned
Mounting frustrations over inconsistent play and a season-ending injury have the Eagles weighing a post-2026 split with their Super Bowl-winning passer as roster uncertainty looms.
Nebraska-Oregon Preview: Why the Huskers Must Win Early
Oregon’s quarterback uncertainty and vulnerable early-down defense give Nebraska a path to bowl eligibility and a defining win under Matt Rhule.
Return of Josh Jacobs should help Packers boost rushing attack
But how much the three-time Pro Bowl running back will contribute right away remains uncertain.
DOJ Revives Business Review Letters, Then Withdraws One
The DOJ relaunched its business review letter program, letting companies seek advance views on proposed conduct. The guidance is narrow, public, nonbinding, and can become outdated as facts or markets change. Companies must disclose substantial information, and the DOJ may decline to respond—so the program offers some guidance, but not immunity or certainty.
Regional Science Consortium Researching Harmful Algal Blooms
If you've noticed large buoys or boats out on the bayfront and wondered what they were, you're not alone. The Regional Science Consortium is collaborating with Princeton Hydro on a research project funded by the U.S. Army Corps of Engineers to study ways to control harmful algal blooms. Dr. Jeanette Schnars, the Executive Director of the Regional Science Consortium, explained the goal of the research."We are researching different ways to control blue-green algae, which creates harmful algal blooms and releases toxins," Dr. Schnars said.The project aims to identify potential techniques for controlling harmful algal blooms in Presque Isle Bay.Schnars explained that people may notice circular floats in the water near Perry's Landing and Liberty Park. Those floats are part of the testing process."You might see a circular float, almost like a hula hoop, that is out in the bay, near Perry's Landing and Liberty Park area, and those limn corrals go all the way to the bottom. And what we will do are some treatments within the limn corral in the bottom," Schnars said.After samples are collected, they are brought back to the laboratory at the Tom Ridge Environmental Center for analysis."A lot of those samples are coming back here. We are going to test them for the harmful algal bloom toxins before, during, and after, and see how effective the testing was," Schnars said.Sarah Magyan, an aquatic biologist with the Regional Science Consortium, explained that the team also collects samples from locations throughout the region."We pull samples every week from 30 different sites, and then we bring those back here, we preserve them and run them through the ELISA test," Magyan said.Schnars said researchers hope the results will help them develop effective ways to reduce harmful algal blooms in the future."If we can do some treatments over space and time in upcoming seasons, we may be able to reduce the number of harmful algal blooms we have in this area," Schnars said.The research is also important for public and animal safety. Magyan explained that toxins produced by certain algae can affect the skin, nervous system or liver.While toxin levels may be low for people, she emphasized the importance of protecting pets that swim in local waterways."Toxins can either be skin toxins, nerve toxins, or liver toxins. While we have low levels for people, it is important that we are keeping our pets safe because we recreate with our animals in the water, and we see hundreds and hundreds of dogs on Presque Isle and the rest of the shoreline," Magyan said.Testing began in September, and Schnars said researchers expect to conduct at least another six to eight weeks of testing to better understand the effectiveness of the treatments.
S&P 500 closes lower to end rocky week
The S&P 500 closed lower as investors weighed AI trade uncertainties and awaited key earnings reports from Alphabet, Microsoft, and Amazon.
Campaigns already know a lot about voters. AI could change what they do with it.
Artificial intelligence is reshaping familiar campaign practices in Minnesota and beyond. Whether it can sway more votes is less certain.
Could Prediction Markets Be a New Hedge Against Business Risk?
Could prediction markets become a new tool for managing business risk? Event-based contracts may help firms hedge revenue uncertainty, but success depends on accurately measuring exposure, matching risks and avoiding conflicts of interest.
France’s Avoids a Debt Downgrade From Moody’s, but Is Given a Warning
Moody’s held the country’s credit rating steady amid political uncertainty and a rise in borrowing costs that have worsened France’s debt situation.
Sun Belt Week 7 Biggest Matchups
Another fun week of Sun Belt football is approaching, and there are certain matchups that can have big implications down the road. Georgia State has been the biggest surprise in the Sun Belt, and a victory over James Madison could do wonders for its confidence. Troy and Louisiana is a marquee matchup for the West …
Scientists discover a plastic-eating “Pac-Man” enzyme with a surprising secret
Scientists have discovered a remarkable “Pac-Man enzyme” that helps bacteria devour certain types of plastic and may offer new hope in the fight against plastic pollution. Researchers found that several biodegradable plastics completely broke down in soil within about a year, while conventional plastic remained largely unchanged.
Shohei Ohtani’s health and a possible lockout loom over an uncertain offseason for the Dodgers
Social determinants of health may increase kidney failure risk after critical illness
New research indicates that certain individual- and neighborhood-level social determinants of health may increase the risk of developing post-discharge kidney failure in patients who developed acute kidney injury while in intensive care.
Bills defense not better, but certainly different, in 2026
Pinpointing how this Bills defense is defense through six games
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
Chris Ilitch Sends Message About Dylan Larkin’s Future
Chris Ilitch addresses Dylan Larkin's uncertain Red Wings future and delivers a message of support amid the former captain's trade request.
Minors account for half of complaints against 'academy-style' entertainment agencies
A total of 366 dispute resolution requests involving 'academy-type' entertainment agencies, those that train their clients, provide auditions or even guarantee certain opportunities for a cost, were filed between 2023 and June this year.
P2 Physio Founder Luis Ferrer Joins Vanessa Certain for Pinecrest Business Spotlight
Getting your Trinity Audio player ready... Luis Ferrer, MPT, CSCS, Founder & CEO of P2 Physio, is the featured guest in this Pinecrest Business Association interview hosted by Vanessa Certain, Owner of VEC Development. Ferrer’s professional background spans physical therapy, strength and conditioning, and healthcare leadership. He earned his master’s degree in physical therapy from […]
Uncertainty grows on Main Street as labor quality, inflation top small business concerns in September: NFIB survey
The NFIB Small Business Optimism Index declined 0.8 points in September to 97.9, one-tenth of a point below the 52-year average of 98.0.
US political uncertainty complicates long-term Artemis commitments, Polish minister says
Polish minister warns that US political and budgetary uncertainty complicates the country's ability to make long-term commitments to NASA's Artemis programme.
Welcome, World Travelers! Dreamfinder and Figment Return to EPCOT — Entertainment & Lifestyle
Welcome, World Travelers! Dreamfinder and Figment Return to EPCOTby James Coulter "One little spark of inspiration is at the heart of all creation." For decades, that spark has been kept alive by a certain purple dragon, and now, after nearly thirty years, the dreamer who created him is finally returning to EPCOT. Earlier this year at the — Local reporting from Polk County, Florida.
Regional efforts are needed to address longstanding behavioral health challenges on the Western Slope, report shows
Over the years, Colorado’s Western Slope has developed a range of services to address the region’s behavioral health challenges. Longstanding challenges with funding uncertainty, provider shortages and gaps in care, however, have limited their ability...
Shohei Ohtani's Health and a Possible Lockout Loom Over an Uncertain Offseason for the Dodgers
LOS ANGELES (AP) — After their earliest postseason exit in three years, the Los Angeles Dodgers head into the offseason facing uncertainty over next year. Shohei Ohtani was dogged by injuries to his left knee and right biceps over the second half and into the playoffs that rendered him ineffective ...
Lamont-Doherty Earth Observatory open house returns with record turnout as it navigates rocky funding future
Columbia’s Lamont-Doherty Earth Observatory held its annual open house on Saturday, opening its doors in Palisades, New York, to more than 2,500 visitors for a day of lab tours, lectures, and hands-on science exhibits amid an uncertain time for science funding.
Fair Value Cut Raises Fresh Questions For Flutter Entertainment Stock (FLUT)
Flutter Entertainment has recently seen analyst fair value estimates marked lower following repeated guidance resets and ongoing regulatory pressures across key betting markets. The split between confidence in FanDuel’s customer momentum and concern over heavier promotions and regulation highlights growing uncertainty around Flutter Entertainment’s near term profitability profile. We will now look at how this more cautious tone on regulation and costs could reshape Flutter Entertainment’s...
Business aviation rides the turbulence in USA
Market continues to thrive, in spite of economic uncertainty.
Stony Brook Researchers David Miloschewsky and Supartha Podder Resolve a Decades-Old Puzzle About the Limits of Quantum Computing
Finding a path through a maze is hard, even for quantum algorithms. A quantum computer can find the exit of a certain kind of maze far faster than a classical computer. But can it also give you directions? David Miloschewsky and Supartha Podder of Stony Brook University’s Department of Computer Science have proven that finding
Michiganders to vote on limiting political donations by utility companies, government contractors
Michigan voters will have a chance to decide whether to limit certain campaign finances through a citizen-led initiative.
Glendale business owner sues federal government over 2025 raid
Mario Ayala said he is trying to keep the business running, but the uncertainty and damage from the raid has taken a toll.
Is the EU research budget actually increasing?
Is a Horizon Europe budget of €158 billion a 10% cut or a significant increase to the EU’s support for research and innovation? What would seem like a question of fact has divided opinion in Brussels since the Irish presidency of the EU Council presented its negotiation box on October 10. The answer depends on factors such as how you adjust for inflation, whether you account for increases in overall EU wealth and if you care about absolute or proportional figures. The €158 billion budget in current prices, proposed by the Irish presidency of the EU Council, was quickly criticised by university lobbies and rejected by the high-level expert group led by former Portuguese science minister Manuel Heitor. It was also decried by the four pro-European political groups in the European Parliament. “How can Europe close its competitiveness gap while cutting the European Competitiveness Fund by 13% and Horizon Europe by nearly 10%?” asked a joint statement by the European People’s Party (EPP), Renew Europe, the Socialists and Democrats and the Greens/European Free Alliance. Together, these parties hold 63% of seats in the Parliament.In stark contrast, Irish foreign affairs minister Helen McEntee said that the proposal “significantly increases investment in competitiveness, research and innovation,” Meanwhile, a presidency press release said that, compared to the current Multiannual Financial Framework (MFF), the proposal would “double the volume of competitiveness related programmes.” So, who is right? That depends on how you make the calculation.Compared to the Commission figure or the previous budget?The first thing to notice is the difference in baselines. When the MEPs say the Irish presidency will cut Horizon Europe by “nearly 10%” they are using the European Commission proposal for the MFF from July 2025, which allocated €175 billion in current prices to Horizon Europe. However, when the Irish foreign affairs minister said the research and competitiveness budget is increasing significantly, she is comparing it to the 2021-27 MFF, which had a Horizon Europe budget of €84.9 billion in 2018 prices.Her point holds when accounting for inflation. Applying a 2% annual inflation rate, the calculation method used by the Commission, the 2021-27 Horizon Europe would have a budget of €97.5 billion in 2025 prices. In comparison, the Irish presidency’s €158 billion figure in current prices translates to €140 billion in 2025 prices. Does the ECF count?But there is more to the dispute. In its statements, the Irish presidency lumped the research budget in with the overall budget for competitiveness. The Parliament statement, however, kept the two separate. This matters because the next MFF includes plans to add a new European Competitiveness Fund (ECF) to fund programmes meant to boost the continent's competitiveness. The Irish negotiating box allocated €245 billion in current prices to this programme.When this is added to the €158 billion for Horizon Europe, as well as programmes such as the EU education programme Erasmus+, the total for “competitiveness, prosperity and security” in the Irish proposal becomes €514 billion in current prices. But it is still uncertain how big a share of this competitiveness budget would go to research. The Commission proposal of July 2025 for the MFF included clear links between the ECF and Horizon Europe, indicating some ECF money will go to research. At the same time, the structure of the ECF is still being negotiated, and a substantial part of its budget is expected to support non-research activities such as defence manufacturing, decarbonisation and digital infrastructure. Related articlesCouncil floats 9.6% budget cut to next Horizon EuropeResearch community to appeal to national governments over planned EU budget cutEU own resources ‘essential’ for future research budget, says leading MEPSo, it is by looking at competitiveness rather than research, or combining the two, that the Irish presidency can claim that its proposed budget will significantly increase investment in competitiveness, research and innovation.According to the Irish presidency proposal, Horizon Europe and other competitiveness-related programmes in the current multiannual budget received €221 billion in current prices. However, since this money is being distributed from 2021 to 2027, it is not directly comparable to the €514 billion in current prices which will be distributed from 2028 to 2034.Research as a proportion of the MFFBut the relative rise in competitiveness-related programmes points to another important distinction: whether you look at the research budget in absolute terms or as a share of the overall MFF. Here, too, the size of the research budget has risen, although only slightly. In the 2021-27 MFF, Horizon Europe accounted for 7% of the total budget. In the Irish presidency’s proposal, it amounts to 8.7%. The share for the total competitiveness envelope went from 17.7% in the current MFF to 28.1% in the Irish presidency proposal.This proportional share may seem irrelevant to universities looking for research funding, but it is becoming significant as budget negotiations between the Parliament, the Commission and the Council begin. On October 2, a group of 17 southern and eastern European countries sent out a statement calling for the EU agriculture and cohesion budgets to be protected. The Parliament’s co-rapporteur on the budget, Siegfried Mureșan of the EPP, has also said that the research envelope is likely to be cut disproportionately as the budget is slimmed down during negotiations.
Costco shakes things up by offering new diaper brand for certain shoppers
Costco has expanded its online diaper selection with Kudos, a premium brand featuring cotton liners and leak protection, but shoppers won't find it in warehouses.
TWICE’s Jihyo Departs JYP Entertainment After 21 Years + Launches New Agency EMITHAUS
Jihyo is beginning a journey with a new company! On October 21, the TWICE member took to her Instagram to share the following handwritten letter: Hello, this is Jihyo. I’m writing today because there’s something I’d like to share with you. After 21 years, my journey with JYP Entertainment, which began when I was just a child, has come to an end. Trying to put 21 years into just a few words is harder than I thought it would be.From childhood through my teenage years and into adulthood, I’ve spent most of my life at JYP.There were good days and difficult ones, but one thing I know for certain is that every one of those moments has shaped who I am today.I want to express my sincere gratitude to everyone at JYP who has been by my side and helped me grow over the years.I will always cherish the time we shared and the memories we made together. To me, independence is not so much a conclusion about the time that has passed, but a choice about how I want to live going forward.As the first step in this new chapter, I have established my own company, EMITHAUS.Just as “EMIT” means to “express or release,” I hope this will be a place where I can freely explore and bring to life even the possibilities within me that I have yet to discover.As I step away from a familiar environment and begin working in new ways, I will approach every decision and every endeavor with even greater thoughtfulness and responsibility. I also want to make it clear that this decision does not mean saying goodbye to the team I’ve been part of for so long.TWICE is an irreplaceable part of my life.Just as I cherish all the years we’ve shared, I look forward to all the moments still ahead of us.I will continue to stand on stage with my members and keep building more memories together for many years to come. Above all, I want to thank ONCE for believing in me and standing by my side for the past 11 years.I know that watching someone grow and change through so many stages of life and continuing to support them along the way is never something to be taken for granted.Thank you for giving me the courage to keep moving forward through your unwavering trust, love, and support.I will continue to fill the years ahead with choices and efforts that stay true to who I am and keep growing as an artist who lives up to all the love and support you’ve given me. Thank you. https://www.instagram.com/p/DevZGTkmTD2/ Jihyo is the third TWICE member to officially leave JYP Entertainment following Jeongyeon and Chaeyoung. Wishing Jihyo all the best on her new start!
Michigan Proposal 2 aims to limit corporate money in politics
Michigan voters will decide in November whether to overhaul the state’s campaign finance laws through a citizen-led ballot initiative that would ban utility companies and certain government contractors from donating to state candidates.
Tulane Defense More Poised for Challenge Memphsi Presents
The Tulane Green Wave have a daunting offense to face this weekend, but it's one they're certainly more used to.
Pens Points: Back Home
Coming off a difficult Western Conference road trip, the Pittsburgh Penguins return home this evening for a matchup with the Florida Panthers at PPG Paints Arena. Sitting on a four game losing skid, the Penguins could certainly use some home cooking to get back on track and right the ship a bit after a tough […]
A note to readers: Science, accountability and elections
Dear readers, As early voting begins, I wanted to share some news — and why it connects to the decisions we make at the ballot box. I’ve been selected for the inaugural cohort of the South Atlantic Climate Journalism Hub mentorship program, hosted by Covering Climate Now. I’m excited to join this group, learn from scientists and fellow journalists, and expand my science reporting. Science directly ties to governance. Local officials make decisions about where development goes, how infrastructure is maintained, what emergency preparations receive funding, and how communities rebuild after disasters. Understanding the evidence behind those decisions helps us evaluate whether our government is serving us well. Here in western North Carolina, those connections are all around us, in Lake Lure and beyond. Flood maps inform decisions about property and development. Engineering assessments help identify risks at dams and bridges. Rainfall forecasts guide emergency preparations. Geological information helps explain landslide hazards. Water testing gives communities information they need to assess conditions. Meteorologists’ knowledge and public perception of weather events shape public safety. Each involves scientific or technical knowledge. Each also raises questions about public responsibility: What did officials know? How did they use that information? What did they tell the public? What did taxpayers receive for their money? A study can identify a problem. Elected officials still have to decide what to do about it, how to pay for it, and how to explain their choices. Reporting should examine both the evidence and the response. That is where I want to strengthen my work. My reporting on Helene recovery, infrastructure, flooding, public safety, and public spending has repeatedly brought me to questions that require scientific expertise alongside public records. This mentorship may help me better understand the research, ask more precise questions, and explain the answers clearly. I also bring the perspective of someone living with these concerns. I live downstream of Lake Lure Dam, and landslides affected my property during Helene. Those experiences bring urgency to my questions. Careful reporting helps establish the answers. Readers deserve to know what the evidence shows, where uncertainty remains, and whether officials accurately describe the information guiding their decisions. You also deserve scrutiny of proposed solutions: what they cost, what they are expected to accomplish, and what risks remain. Access to that information matters. As a mostly deaf journalist who relies on written communication, I will continue pressing for written public warnings, records, and explanations that people can read and use in real time. As you consider the candidates seeking your vote, consider how they approach evidence, preparedness, and transparency. Do they support local journalism, even when it’s not parroting a press release? Do they explain weather events clearly in plain English and explain their decisions after them? Make supporting records available? Acknowledge uncertainty? Follow through when a report identifies a risk? Those are practical questions about governing. Thank you for supporting Cops & Congress and the work that makes these questions part of the public conversation. I’m grateful to David Dickson and the CC Now team for this opportunity, and I look forward to bringing what I learn back to you. Annie DanceEditor & Publisher, Cops & Congress — Learn more about this newsletter, ethics policy, how you can help shape this work, and support it. Follow on X and Facebook. Send constructive criticism, fan mail, and tips with public documents for future stories: CopsandCongress@gmail.com ICYMI: View the Cops & Congress archive — Annie Dance is the publisher of Cops & Congress, a newsletter that analyzes what happens when crime, courts, disaster, democracy, and small-town policies collide. Views expressed here are covered by the First Amendment. Dance has a Bachelor of Arts from Manhattan University in Communication with a focus in Journalism and Government. She has been a journalist for over 20 years. Share Upgrade now or give a gift subscription
Va. lawmakers, Spanberger grapple with loss of federal healthcare funds for trans youth
Federal Medicaid and Children’s Health Insurance Program money can no longer be used for certain gender-affirming care to young people in Virginia and other states, after a new U.S. Department of Health and Human Services rule took effect on Oct. 13.
Have scientists finally found a way to save the banana from disaster?
With the climate crisis and diseases threatening one of the world’s most popular fruits, researchers are hoping a breakthrough in breeding techniques could give the Cavendish banana a certain future
Joe Burrow has never hidden his political beliefs
Cincinnati Bengals quarterback Joe Burrow didn’t have much to say about Vice President JD Vance’s surprise visit to practice on Wednesday. But for a player who has rarely been shy about speaking his mind, his short response certainly caught some attention. Burrow said that he didn’t get a chance to meet Vance, noting that the…
Why this Glendale business owner is suing the U.S. government
Mario Ayala said he is trying to keep the business running, but the uncertainty and damage from the raid has taken a toll. Zach Prelutsky reports.