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Entertainment lineup announced for Red River Valley Fair

WEST FARGO (KFGO) - The Red River Valley Fair just announced the 2026 grandstand entertainment lineup, bringin...

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Mar 24 • 12:16 PM EDT • Entertainment • kfgo.com
Kari Nadeau named dean of the UCLA Fielding School of Public Health

Nadeau, currently chair of environmental health at Harvard’s T.H. Chan School of Public Health, will begin her new role in July.

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Mar 24 • 12:00 PM EDT • Health • newsroom.ucla.edu
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Jacobs Entertainment begins construction on downtown sports fields

Jacobs Entertainment has begun building the flat fields

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Mar 24 • 11:52 AM EDT • Entertainment • kolotv.com
Lowndes County leaders cut ribbon on medical, mental health jail expansion

The new facility includes 60 cells with a total of 90 beds, according to the county.

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Mar 24 • 11:51 AM EDT • Health • witn.com
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World Tuberculosis Day 2026: Primary health care key to a more accessible, people-centered response

In the Americas, an estimated 350,000 people fell ill with tuberculosis in 2024, and nearly 77,000 were not diagnosed, highlighting the need to bring diagnosis and treatment closer to communities.

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Mar 24 • 11:19 AM EDT • Health • paho.org
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ESPN to premiere ‘Sports Heaven: The Birth of ESPN’ on April 6

ESPN today announced that “Sports Heaven: The Birth of ESPN” will premiere on April 6 at 8:30 p.m. ET on ESPN.

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Mar 24 • 11:08 AM EDT • Sports • espnpressroom.com
Blog explains why context matters in discussions on health care spending

An AHA blog published March 24 responds to a recent KFF brief on the role of hospital care in recent health care spending growth.

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Mar 24 • 10:50 AM EDT • Health • aha.org
Service & Solidarity Spotlight: New Jersey Health Care Workers Vote to Join HPAE

New Jersey health care workers at Samaritan Healthcare & Hospice and Inspira Health have both voted to join the Health Professionals and Allied Employees (HPAE), an affiliate of the AFT.

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Mar 24 • 10:13 AM EDT • Health • aflcio.org
Lawmakers weighed Wyoming Health Department budget cuts. They never came.

by Maggie Mullen, WyoFile After the Wyoming Freedom Caucus told voters last year it aimed to “DOGE” the state’s next two-year budget by

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Mar 24 • 9:18 AM EDT • Health • oilcity.news
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Partnership Brings Nursing Students to Front Lines of Community Health in South DeKalb

A new partnership between nursing students at Georgia State University’s Perimeter College and New Life Community Alliance creates opportunities for students to gain hands-on experience.

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Mar 24 • 9:00 AM EDT • Health • news.gsu.edu
Tacoma Arts Live, longtime WA arts institution, files for receivership

Tacoma Arts Live, a longtime performing arts organization, has filed for receivership. The court process is similar to bankruptcy. Here's what we know.

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Mar 24 • 9:00 AM EDT • Entertainment • yakimaherald.com
Lessons from China—Questrom Class Took BU Students on Memorable Business Trip

Over spring break, 25 Boston University students joined Professor, Greg Stoller to see what Chinese companies could teach them

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Mar 24 • 8:47 AM EDT • Business • bu.edu
TODAY | City of Tampa hosts Bridges To Business Event

City of Tampa Hosts Networking, Information Event For Local BusinessesThe City of Tampa is hosting a Job Order Contracting Information Session & Networking event today at City Center at Hanna Avenue.

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Mar 24 • 8:46 AM EDT • Business • tampa.gov
What's for Lunch? 25 Years of Inspired Science in Schools

The Sisters in Science student organization has quietly shaped young learners in Kalamazoo by presenting hands-on experiences in schools.

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Mar 24 • 8:37 AM EDT • Science • kzoo.edu
Is it ‘Ih-ran’ or ‘E-ron’? Inside the politics of pronunciation

Both President Trump and Vice President Vance pronounce Iran as ‘Ih-RAN,’ not ‘Ih-RON.’ A linguist says that how the country’s name is pronounced may be a political choice.

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Mar 24 • 8:28 AM EDT • Politics • theconversation.com
Alliant Private Client Strengthens Entertainment Practice with Addition of Michelle Quintero

IRVINE, Calif., March 24, 2026--Michelle Quintero has joined Alliant Insurance Services as Executive Vice President with Alliant Private Client. Based on the West Coast and recognized by Risk & Insurance® as a 2026 Entertainment, Hospitality & Gaming Power Broker®, Quintero brings more than 25 years of technical acumen and delivers tailored solutions to high-profile and celebrated individuals in music, film, and live events.

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Mar 24 • 8:05 AM EDT • Entertainment • finance.yahoo.com
Salamander Migration Has New Citizen Science Component

Each spring, blue-spotted salamanders emerge from their underground burrows at Presque Isle Park in Marquette and venture across the road to lay their eggs. Northern Michigan University students have been involved in conservation, data collection and public education efforts for this annual event, but this year, the general public is invited to play a more active role in salamander migration research. Northern Michigan University Biology Department Head Jill Leonard encourages community members to participate in the Marquette Citizen Science Project.

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Mar 24 • 8:00 AM EDT • Science • news.nmu.edu
Registration opens for hands-on ocean science program for teachers this summer

Registration has officially opened for BLOOM Educators, Bigelow Laboratory for Ocean Sciences' professional development program offering hands-on training for middle and high school teachers.

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Mar 24 • 8:00 AM EDT • Science • penbaypilot.com
Cone Health Cardiologist Named 2026 RISE Health Care Hero

Dr. Kardie Tobb wins National Award

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Mar 24 • 8:00 AM EDT • Health • conehealth.com
UCLA Health podcast shines a light on colorectal cancer prevention, early detection and rising risks

UCLA Health's podcast episode on colorectal cancer, featuring Dr. Eve Glazier, Katie Couric and Dr. Fola May, highlights the critical need for prevention and early detection amid rising risks, particularly among younger adults. The discussion focuses on cancer screening, lifestyle modifications and advocacy to reduce the incidence of this disease.

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Mar 24 • 8:00 AM EDT • Health • uclahealth.org
Football Hall of Fame to Honor St. John’s Alumnus Who Led Landmark Sports Statistics Firm

A St.

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Mar 24 • 8:00 AM EDT • Sports • stjohns.edu
4 Pitt people were named Pittsburgh Business Times 2026 Women of Influence

The awards recognize the region’s businesswomen, including one Pitt dean and three alumnae, who make impactful change by leading organizations.

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Mar 24 • 8:00 AM EDT • Business • pittwire.pitt.edu
Helping seniors thrive through connection

ETSU is one of three universities nationwide selected to develop senior nutrition programs.

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Mar 24 • 8:00 AM EDT • Health • news.etsu.edu
Mad Mercs are back: AMG confirms Black Series GT is officially coming

And it’ll be a homologation car for the next-gen GT3 car

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Mar 24 • 7:14 AM EDT • Technology • topgear.com
Context Matters: The Truth about Hospital Spending and Health Care Costs

Recent analyses of national health spending have again placed hospitals at the center of the affordability debate.

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Mar 24 • 6:49 AM EDT • Health • aha.org
From data to culture: Baptist Health’s well-being journey

A defining moment became a catalyst as Baptist Health strengthened leadership engagement, secured local champions to expand physician support across Kentucky.

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Mar 24 • 3:00 AM EDT • Health • ama-assn.org
High school sports results for Monday, March 23, 2026

MONDAY’S RESULTS Baseball WPIAL CLASS 5A Section 1 Latrobe 13, Penn-Trafford 12 Plum 9, Armstrong 3 WPIAL CLASS 3A Section 3 Deer Lakes 10, Southmoreland...

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Mar 23 • 11:15 PM EDT • Sports • post-gazette.com
Anthropic's Claude gets computer use capabilities in preview
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Mar 23 • 8:49 PM EDT • Technology • siliconangle.com
How Pixar Got the Science Right in Hoppers

Meet the researcher who informed the writers about beaver behavior and threats to their habitat

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Mar 23 • 8:00 PM EDT • Science • sierraclub.org
Can pesticide exposure before pregnancy affect babies’ health?

A study co-authored by UCLA researchers suggests certain chemical compounds correlated with lower newborn health scores.

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Mar 23 • 7:33 PM EDT • Health • newsroom.ucla.edu
'Sled head': Lawsuits against USA Bobsled/Skeleton allege brain injury

Three personal injury lawsuits have been filed on behalf of elite bobsledders who claim officials intentionally concealed evidence that the sport causes brain injuries.

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Mar 23 • 4:31 PM EDT • Sports • latimes.com
Meet Three Sagehens Playing Spring Sports in 2026 | Pomona College in Claremont, California

The spring sports season offers a smorgasbord of options for Sagehens fans, with teams taking to the diamond, track, pool, field and golf course to test their mettle against Division III athletes from across the country.

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Mar 23 • 3:30 PM EDT • Sports • pomona.edu
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Two of my favorite color e-book readers are the cheapest they’ve been in months

They’re the cheapest they’ve been since Black Friday.

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Mar 23 • 3:30 PM EDT • Technology • theverge.com
Design Files: Mirrodin, Part 4

Mark finishes his trip through Mirrodin's design handoff file with a look at the set's rare artifacts and lands.

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Mar 23 • 12:00 PM EDT • Technology • magic.wizards.com
Ewing to announce entertainment for Omaha’s Memorial Park concert

The event is happening on Friday, June 26.

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Mar 23 • 11:55 AM EDT • Entertainment • 1011now.com
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Ewing to announce entertainment for Omaha’s Memorial Park concert

The event is happening on Friday, June 26.

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Mar 23 • 11:55 AM EDT • Entertainment • wowt.com
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Trump sued by historic preservation groups to block Kennedy Center changes

A coalition of preservation groups is suing to stop major physical changes at the Kennedy Center under President Donald Trump’s renovation plans. On Monday, the groups filed a lawsuit against

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Mar 23 • 11:41 AM EDT • Entertainment • lancasteronline.com
Firefox 149 Now Available With XDG Portal File Picker, Rust-Based JPEG-XL Decoder

Firefox 149.0 release binaries are now available with a wide assortment of improvements for this month's update to the cross-platform Mozilla web browser solution.

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Mar 23 • 10:06 AM EDT • Technology • phoronix.com
Shorebird Science and Conservation Collective Shows Big Data Can Protect Birds

New research published in the journal Conservation Biology provides a model for big data to inform conservation.

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Mar 23 • 10:00 AM EDT • Science • nationalzoo.si.edu
Register for 25Live trainings at Health Sciences Center

The Facilities Planning and Scheduling team will provide a 25Live training session from 2-3 p.m. April 8 at the Health Sciences Center, Room 2912.

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Mar 23 • 8:06 AM EDT • Health • enews.wvu.edu
Small Business Promotion Week: Hey Honey Marketplace

Jennifer Reeves, nurse turned boutique owner, came up with the idea for Hey Honey Marketplace, a boutique on Abram Street that aims to not just be a store but a community gathering place for women.

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Mar 23 • 8:00 AM EDT • Business • arlingtontx.gov
Inaugural Health Care by Food research award honors excellence in food is medicine science

DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...

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Mar 23 • 8:00 AM EDT • Science • newsroom.heart.org
Funny business: Humor scholars on whether jokes help or hurt at work

Leeds researchers Tony Kong and Peter McGraw agree humor has real workplace benefits, but pulling it off can be tricky.

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Mar 23 • 8:00 AM EDT • Business • colorado.edu
UNH Paul College Top Public Business School in New England for Academic Experience and Career Outcomes

UNH’s Paul College ranks No. 63 nationally in 2026 Poets&Quants rankings, leading New England public schools in academic experience and career outcomes.

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Mar 23 • 8:00 AM EDT • Business • unh.edu
Inaugural Health Care by Food research award honors excellence in food is medicine science

DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...

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Mar 23 • 8:00 AM EDT • Health • newsroom.heart.org
Free sports physicals return for public school students in Flagler and Volusia counties

Thousands of middle and high school students in public schools across Volusia and Flagler counties can receive free sports physicals this spring as AdventHealth helps young athletes prepare safely for the upcoming season.

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Mar 23 • 8:00 AM EDT • Sports • adventhealth.com
PATLABOR the Case Files announced for PS5, PC

Publisher Good Smile Company and developer Chime Corporation have announced 3D action game PATLABOR the Case Files

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Mar 23 • 7:00 AM EDT • Technology • gematsu.com
Samsung adds native AirDrop support to Galaxy S26 devices

Share files with Apple-using friends

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Mar 23 • 5:47 AM EDT • Technology • theverge.com
Ambani's Reliance Jio: businesses and investors of the IPO-bound firm

Indian billionaire Mukesh Ambani's Reliance Jio Platforms is gearing up to file papers seeking regulatory approvals for a Mumbai listing, in what is likely to be the biggest-ever stock offering in the country.

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Mar 23 • 5:39 AM EDT • Business • reuters.com
Turning coal to medicines: Chinese scientists bring a 160-year-old dream to life

Study cracks a puzzle that has baffled scientists and will reshape modern medicine production as the world reels from a global oil shortage.

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Mar 23 • 2:23 AM EDT • Science • scmp.com
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A DNA test ruled him out. He was convicted of murder anyway.

Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.

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Mar 22 • 9:57 PM EDT • Science • bostonglobe.com
Eye of Terror – New rules for Defilers, Mutilators, and Kravek Morne

See the new datasheets now.

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Mar 22 • 8:00 PM EDT • Technology • warhammer-community.com
Art and science collide in alumna’s artwork

Juliet Fiss, an RIT imaging science alumna, uses algorithms and formulas to create artwork, including a piece at RIT’s Carlson Center.

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Mar 22 • 8:00 PM EDT • Science • rit.edu
‘We’ve got some unfinished business’: Corey Gipson reflects on historic Austin Peay season

Austin Peay men's basketball head coach Corey Gipson recently reflected on his 2025-26 season and revealed what makes Clarksville special.

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Mar 22 • 3:29 PM EDT • Business • clarksvillenow.com
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Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Drew Barrymore says talk show audience member once criticized her dating profile

Drew Barrymore is remembering the time an audience member on her talk show gave his honest thoughts about her dating profile: 'I would probably run away.'

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Mar 22 • 9:30 AM EDT • Entertainment • ew.com
'Completely lawless': Why this congresswoman wants Pam Bondi impeached

From the Epstein files to the integrity of prosecutions, Democratic Congresswoman Summer Lee says Attorney General Pam Bondi is damaging the DOJ.

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Mar 22 • 5:05 AM EDT • Politics • usatoday.com
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Flexitarian and the MIND included in top diets for a healthy brain, according to U.S. News

Discover four top diets that may support sharper focus, steadier mood, and long-term brain resilience

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Mar 22 • 5:00 AM EDT • Health • qz.com
The Antidote to Our Growing Crises Must Transcend Politics

Each day, the challenges in our nation pile up. In just recent weeks, there has been the ongoing war in Iran and the Middle East, and ongoing debates about the growing negative impact of the Internet, looming AI challenges, and the Epstein files. The anticipation of divisive, even ugly, midterm elec...

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Mar 22 • 1:40 AM EDT • Politics • thefulcrum.us
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Bridging medical realities in the study of technology and health

Anthropologist and MIT Associate Professor Amy Moran-Thomas studies medical technologies and how they fail to reach some communities. “What anthropology has to offer the world, and other knowledge systems, is the insights of people that might be missing from many accounts,” she says.

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Mar 22 • 12:00 AM EDT • Health • news.mit.edu
Healthy Kids Day collaboration with PTO Science Night, April 17

FROM FACEBOOK__Get ready for an action-packed evening! This year, the Bluffton YMCA Healthy Kids Day is joining forces with the Bluffton Schools PTO Science Night for one massive community event!

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Mar 21 • 8:00 PM EDT • Science • blufftonicon.com
Dana Walden unveils leaders of expanded Disney Entertainment

Dana Walden, the incoming President and Chief Creative Officer of The Walt Disney Company, has unveiled the new leadership structure for Disney Entertainment, bringing together the company’s streaming, film, and television businesses along with its games and digital entertainment division.

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Mar 21 • 8:00 PM EDT • Entertainment • ibc.org
Politics Unplugged (Full Episode) March 22, 2026

This week on Politics Unplugged, Progressive activist Kai Newkirk explains why he is running to unseat Democratic incumbent Greg Stanton in the congressional race in CD4. Then, consultants Marcus Dell’Artino and Matt Grodsky discuss the fallout from the Cesar Chavez allegations and the political importance of high gas prices.

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Mar 21 • 6:29 PM EDT • Politics • azfamily.com
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Robert Mueller, former special counsel who led Trump-Russia probe, dies

A decorated Marine and longtime law enforcement leader, Mueller served as FBI director before taking on the high-profile investigation in 2017.

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Mar 21 • 2:19 PM EDT • Politics • nbcnews.com
High-Signal Publisher
Flood-prone Kīhei Crossroads for sale as its popular businesses remain closed from latest storm

In June of 2025, the popular strip shopping center near the Kīhei Canoe Club and the surrounding vacant land went on the market for $15.85 million.

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Mar 21 • 12:01 PM EDT • Business • mauinow.com
The reality of death and the Trinitarian “science” of salvation

Readings: • Ez. 37:12-14 • Psa. 130:1-2, 3-4, 5-6, 7-8 • Rom. 8:8-11 • Jn. 11:1-45 We live in a time of astounding scientific breakthroughs and unprecedented medical marvels. In my lifetime alone, we’ve witnessed men landing and […]

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Mar 21 • 12:00 PM EDT • Science • catholicworldreport.com
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Data Science Use Cases: 15 Real-World Applications Transforming Enterprise Operations

Explore 15 enterprise data science applications across manufacturing, healthcare, retail, and finance — with case studies, code examples, and proven outcomes.

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Mar 20 • 7:02 PM EDT • Science • databricks.com
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Nuclear reactor developer X‑energy files for US IPO

X-energy ​has filed for ‌an initial public offering in ​the United States, ​it said on ⁠Friday, as the ​reactor developer aims ​to tap growing investor enthusiasm for nuclear ​power.

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Mar 20 • 5:32 PM EDT • Business • reuters.com
Political Science study reveals how Americans decide who counts as a

The term “person of color” has grown increasingly common in American public life. A new Berkeley Political Science paper, “Who Counts as a ‘Person of Color’? The Roles of Ancestry, Phenotype,

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Mar 20 • 5:09 PM EDT • Science • ls.berkeley.edu
Mark Robinson admits ‘I lied’ about CNN story

Former North Carolina Lt. Gov. Mark Robinson admitted he lied about a bombshell CNN KFile investigation during the final months of his 2024 gubernatorial campaign, uncovering his extensive history of posting inflammatory and racist comments on a pornography website.

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Mar 20 • 5:03 PM EDT • Politics • cnn.com
Shelby’s Trio hosts Chamber of Commerce Business After Hours

Shelby's Trio hosted the Clarksville Area Chamber of Commerce Business After Hours event on Thursday.

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Mar 20 • 3:46 PM EDT • Business • clarksvillenow.com
Building scientists in Charlottesville: Inside the UVA Innovation Hub

The award-winning partnership between the city schools and UVA’s School of Education expands learning into the community.

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Mar 20 • 3:09 PM EDT • Science • news.virginia.edu
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Windows 11 is finally getting a movable taskbar

Microsoft is also working on a smaller taskbar option

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Mar 20 • 3:00 PM EDT • Technology • theverge.com
Scientists Make a Major Breakthrough in Solving a Hair-Raising Mystery About Static Electricity

The findings can help explain the physics behind phenomena like volcanic lightning

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Mar 20 • 11:29 AM EDT • Science • smithsonianmag.com
Google Search is now using AI to replace headlines

Let us know if you see more.

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Mar 20 • 10:30 AM EDT • Technology • theverge.com
Federal judge in Oregon rules US government overreached with transgender health care declaration

The judge’s ruling Thursday in Oregon is part of multistate lawsuit filed against the U.S. Department of Health and Human Services, its secretary, Robert F. Kennedy Jr., and its inspector general.

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Mar 20 • 10:15 AM EDT • Health • opb.org
Abramson advancing research at intersection of health, inequality and AI

Corey Abramson's research earns him a year in residence at the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University.

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Mar 20 • 8:00 AM EDT • Health • news.rice.edu
Welcome 2 New Restaurants to East Carson Street Business District

Mayor O'Connor and South Side Chamber of Commerce Welcome 2 New Restaurants to East Carson Street Business District

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Mar 20 • 8:00 AM EDT • Business • pittsburghpa.gov
At UN, Holy See allies question reliance on hormonal treatments for women

The event was co-sponsored by the Fertility Education and Medical Management Foundation, a U.S.-based group that created an app that encourages women to track their cycles.

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Mar 20 • 8:00 AM EDT • Health • ncronline.org
Aditya Kaddu

My goal is that my career path always enables me to create real, positive impact on others.

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Mar 20 • 8:00 AM EDT • Business • gsb.stanford.edu
2026 NFL Draft Profile: Vanderbilt tight end Eli Stowers

The Denver Broncos need to add talent to their tight end group. Vanderbilt prospect Eli Stowers is one they should consider.

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Mar 20 • 8:00 AM EDT • Sports • sports.yahoo.com
Exclusive: Amazon plans smartphone comeback more than a decade after Fire Phone flop

In 2014, Amazon introduced its first smartphone, hoping to take on Apple and Samsung. Instead, the Fire Phone - overseen directly by founder Jeff Bezos - was scrapped in barely over a year, one of Amazon’s highest-profile flops.

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Mar 20 • 6:01 AM EDT • Technology • reuters.com
What doctors wish patients knew about social media’s health impact

From mere FOMO to anxiety and depression, social media platforms can pose harms and benefits. Three physicians discuss how to balance the positive and negative impacts.

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Mar 20 • 3:00 AM EDT • Health • ama-assn.org
Verdict on Chatbots in Mental Health Screenings? Too Judgmental

Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered a neutral option for sharing mental health concerns. In a recent test of these common assumptions, however, a University of Texas at Dallas researcher […]

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Mar 19 • 11:00 PM EDT • Health • news.utdallas.edu
Albuquerque The Magazine Recognizes 7 UNM Health ‘Top Docs’ for 2026

UNM Health recognizes over 1,000 dedicated physicians who create advancements in medical care as they educate and develop the next generation of health care professionals and scientists. This year, UNM Health honors seven physicians recognized as 2026...

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Mar 19 • 8:00 PM EDT • Health • hscnews.unm.edu
New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

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Mar 19 • 5:28 PM EDT • Technology • gamefile.news
Alien Life Could Look Nothing Like What We Expect. Here's How Microbes Beyond Earth Might Live Without Liquid Water

Like the lead character of “Project Hail Mary,” some scientists are proposing ways that life might exist beyond a star’s “habitable zone,” often considered the gold standard of potential livability

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Mar 19 • 5:11 PM EDT • Science • smithsonianmag.com
Temple Health Appoints Robert A. Winn, MD, as Cancer Center Director for Fox Chase Cancer Center

Temple Health today announced the appointment of Robert A. Winn, MD, as the next Cancer Center Director for Fox Chase Cancer Center, marking a defining moment that will shape the future of one of the nation’s leading National Cancer Institute-designated Comprehensive Cancer Centers.

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Mar 19 • 4:22 PM EDT • Health • foxchase.org
Trump admin. launches investigation of states mandating health insurance covers abortion

The Trump administration said Thursday that it has launched investigations into 13 states - including Oregon and Washington - that require state-regulated healt

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Mar 19 • 3:19 PM EDT • Health • katu.com
Lawsuit Accuses Justice Dept. Leadership of ‘Political Retribution’

The suit filed by two fired F.B.I. agents aimed to hold the Trump administration accountable for the purge of personnel who had worked on the investigations of Mr. Trump or his allies.

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Mar 19 • 12:50 PM EDT • Politics • nytimes.com
Babson Taps Multigenerational Business Leaders for 2026 Commencement Addresses

CEO and Executive Chairman of Metropoulos & Co. C. Dean Metropoulos '67, MBA'68, will give the undergraduate Commencement address, with Cisneros CEO Adriana Cisneros speaking at the graduate Commencement ceremony.Wellesley, Massachusetts--(Newsfile Corp. - March 19, 2026) - Babson College will honor the achievements of more than 740 undergraduate and 540 graduate members of the Class of 2026 before thousands of family members, faculty, friends, colleagues, and peers in separate on-campus...

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Mar 19 • 12:37 PM EDT • Business • finance.yahoo.com
Xiaomi releases new lightweight laptop with Intel Panther Lake and 120 Hz OLED display

Xiaomi has released a new 14-inch laptop featuring Intel's Panther Lake platform. Available with up to 32 GB of RAM, the Book Pro 14 combines a 120 Hz OLED display with 72 Wh battery inside a housing that tips the scales at barely over a kilo.

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Mar 19 • 10:20 AM EDT • Technology • notebookcheck.net
Science stars at special UChicago, Argonne screening of ‘Project Hail Mary’

Researchers and students marked the new film with a panel discussion, hands-on science demos and a shared love of discovery

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Mar 19 • 8:00 AM EDT • Science • news.uchicago.edu
Dan Nelms

I realized Stanford GSB could help round out my skill set and prepare me to be an executive for a growth startup.

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Mar 19 • 8:00 AM EDT • Business • gsb.stanford.edu
Cycle Nova: Villanova students unite to honor a legacy and advance heart health

Villanova, Pa., March 17, 2026 — Beat for Good, Villanova University’s student‑run organization dedicated to supporting individuals and families affected by cardiovascular disease, hosted its inaugural cycling fundraiser, Cycle Nova, on Saturday, March...

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Mar 19 • 8:00 AM EDT • Health • newsroom.heart.org
High School Students Present Ideas to St. John’s Experts in Tobin Business Plan Competition

Area high school students brought their business visions to St.

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Mar 19 • 8:00 AM EDT • Business • stjohns.edu
Interventional radiology breakthrough in portal vein thrombosis treatment

A UCLA Health interventional radiologist has successfully performed the first pediatric percutaneous spleno-renal shunt procedure to treat severe portal hypertension in a 6-year-old patient. This minimally invasive procedure aims to relieve complications associated with portal vein thrombosis, showing promising long-term outcomes.

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Mar 19 • 8:00 AM EDT • Health • uclahealth.org
What sports can teach us about Houston: Black Houston(s) Symposium returns to Rice

The fourth annual event will take place over March 26-27, bringing scholars, athletes, artists and community members together to examine sports as a social and cultural force.

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Mar 19 • 8:00 AM EDT • Sports • news.rice.edu
Cone Health to Cut Ribbon on Two New Mobile Health Units

Two New Mobile Units Launch To Meet The Needs of the Community

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Mar 19 • 8:00 AM EDT • Health • conehealth.com
A public health professor is bringing the National Bioethics Bowl to Pitt

The competition, organized this year by Cindy McCarthy, gives students a chance to consider challenging questions about health and technology.

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Mar 19 • 8:00 AM EDT • Health • pittwire.pitt.edu