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Nobel Prize in physics awarded to Francis Halzen for groundbreaking neutrino research
The Royal Swedish Academy of Sciences has awarded the 2026 Nobel Prize in physics to Francis Halzen of the University of Wisconsin–Madison.
UNC Health building a new medical campus near Research Triangle Park
The campus will eventually have a 152-bed community hospital in Durham off N.C. 55, just outside Wake County, Cary and RTP.
Marquette professor collaborates on Antarctic research honored with 2026 Nobel Prize
Dr. Karen Andeen conducted neutrino research in a Nobel Prize-winning laboratory located at the South Pole.
UMaine study explores whether music can help older adults maintain brain health
University of Maine researchers are studying whether listening to music or learning to play an instrument could help older adults maintain cognitive function as they age. The three-year study, led by Rebecca MacAulay, an associate professor of psychology at UMaine, is funded by the National Institute on Aging and will…
Researchers find nearly $80 million in AI political ads, most don’t disclose AI
AI is reshaping political advertising landscape ahead of the midterms, but most campaigns aren’t disclosing AI use, making it harder for voters to do a fair assessment.
We studied American Jews’ mental health after Oct. 7. They’re not OK.
Research showed invalidation in ways that were painful, isolating and sometimes startling, writes a co-founder of The Jewish Community Mental Health Initiative.
Research suggests women living in states with abortion bans bear higher health insurance costs
New preliminary research from the University of Michigan shows women living in states with post-Dobbs abortion bans may be more likely to shoulder costs for employer-sponsored health insurance premiums, with federal data reflecting a 5.4% increase in annual premium expenditures for those women after 2022, when most abortion bans went into effect.
Former Texas Health Resources executive named to lead Blue Zones
Blue Zones, the global leader in longevity research and helping people live longer, healthier lives, announced today the appointment of Brett McClung as
Clarkson University Science Cafe series returns to Potsdam this fall
POTSDAM — Clarkson University’s Science Café series returns to downtown Potsdam this fall, bringing researchers and community members together for informal conversations on topics ranging from childhood development and virtual
UNC Health breaks ground on Research Triangle Park hospital
UNC Health views the hospital as critical to keeping up with the Triangle's growing population.
U of A to host hundreds of science writers
The university will host ScienceWriters2027, giving science journalists and communicators a firsthand look at the people, discoveries and facilities behind U of A research.
Patagonia’s CEO is worried about political apathy—so the company offered 112,000 people $100 to help 3 friends plan to vote
The $11.2 million incentive disappeared in four days. Researchers say a friend’s nudge could help turn environmental concern into votes.
Elanco, Purdue planning research institute at One Health Innovation District
The One Health Research Institute, just west of Elanco’s headquarters, is expected to open in 2030.
When Did Animals First Evolve? New Evidence From Mongolia Suggests It Could Be As Far Back As 800 Million Years Ago
New research pushes back what previously had been the early limit of animal evolution by 200 million years.
Two URI physics professors receive NSF awards to further study science behind black holes
KINGSTON, R.I. – Oct. 6, 2026 – Black holes and their complexity continue to fascinate astrophysics researchers around the world, including those at the University of Rhode Island. Researchers are drawn to how these massive, dense concentrations of energy affect their surroundings and want to learn more about how the universe as a whole was […]
Van Andel Institute’s Dr. Derek Janssens receives a New Innovator Award from the National Institutes of Health Common Fund
Read about Van Andel Institute’s Dr. Derek Janssens receives a New Innovator Award from the National Institutes of Health Common Fund on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
Northwell Health Launches the Institute for Healthy Aging, Integrating 28 Hospitals, Research and Community Programs to Promote Longevity and Support People as They Age
NEW HYDE PARK, N.Y.--(BUSINESS WIRE)--Oct 6, 2026--
Peng Gao receives NIH New Innovator Award for research measuring chemical exposure in blood and tissues | Harvard T.H. Chan School of Public Health
Peng Gao was awarded an NIH Director's New Innovator Award from the NIH's High-Risk, High-Reward Research program.
Old Dominion University Researchers Explore Connection Between Sinus Health and Voice Problems
A stuffy nose, facial pressure and a diminished sense of smell are familiar symptoms for people with chronic sinus problems. Changes to the voice may be less obvious. Researchers in Macon & Joan Brock Virginia Health Sciences at Old Dominion University are exploring a connection patients may not always recognize: the relationship between sinus conditions and voice problems.
Scientists finally understand why Antarctica froze long before the Arctic - Futura-Sciences
The research shows that the creation of an escarpment, plateau, and mountain region in East Antarctica produced the high terrain needed for snow and ice to build up. The process began when Antarctica and Africa started pulling apart during the Jurassic Period, between 201 and 143 million years ago. Powerful...
WHO: No further signs of infections at Russian plague lab
The World Health Organization (WHO) said Monday there were no further signs of infections at the Irkutsk Research Anti-Plague Institute of Siberia, following one researcher at the facility reported…
AMN Healthcare Research Links Hospital Digital Investment to Better Patient Experience
/PRNewswire/ -- New proprietary research from AMN Healthcare, the leader and innovator in total talent solutions for healthcare organizations, examines the...
Is it possible to preserve your memories before dying? The science is moving beyond science fiction
For most of history, preserving someone’s memories after death meant relying on photographs, letters, stories and the recollections of other people. Technology is now pushing that idea much further. Scientists can record parts of brain activity linked to memory, researchers are mapping the neural networks that store experiences, and digital systems can preserve enormous amounts of a person’s voice, writing, images and personal history. That still falls far short of copying a mind. No technology
Going International: How Global South Journalists Can Elevate Local Science Stories
For journalists in the Global South, access to local science presents an opportunity to bring this knowledge to a wider audience via international outlets. Regional studies and perspectives can inform broader conversations about science, highlight multinational patterns, and elevate research conducted outside of traditional scientific centers. This story offers strategies to find stories, connect with international editors, and meet the needs of audiences that may know little about the place where a story is unfolding.
AIAS+ 2026 Brings Leading Scientists to San Francisco to Explore How AI Is Changing Scientific Discovery
The Tianqiao and Chrissy Chen Institute will bring leading scientists, AI researchers, engineers and innovators to San Francisco November 5–7 for AIAS+ 2026: AI Advancing Science & Society, a three-day symposium focused on one of the most consequential questions facing research today: How can artificial intelligence help scientists move beyond analyzing what is already known and accelerate new discovery?
Industry Insights: Q&A with Estée Lauder’s SVP of Global Clinical, Consumer Sciences on One-of-a-Kind Complexion Research
“A shade can be technically close to a person’s skin tone and still not look completely natural in every situation.”
Catalytic confessions and a quest for Matt Damon: PodCAT puts science on mic
PodCAT, hosted by researchers from Rice, the University of Rochester and Penn State University, is a podcast devoted to the science of catalysis, academic careers and the surprisingly personal stories of the researchers themselves.
Mizzou expands support for NSF Graduate Research Fellowship applicants
Oct. 6, 2026Photo by Sam Cox The University of Missouri Office of Global and National […]
Sun Life research reveals the ripple effect behind small business success
As Canada's small businesses navigate a rapidly changing business environment, new research from Sun Life shows that success is about more than growing revenue. It's about building resilience. When owners feel confident in their ability to weather challenges and plan for the future, they're more likely to invest in their employees, strengthen their businesses and create lasting impact for the people who depend on them. The findings align closely with how Sun Life supports small business owners,
What if death from aging becomes preventable? The science is no longer purely theoretical
Most medicine waits for aging to produce a recognizable disease and then tries to treat that disease. A growing field of researchers is pursuing a more ambitious idea: intervene earlier in the biologi...
The 2026 Oscarsborg Symposium Strengthens Nordic Business-State Networks in Defence and Preparedness
The 2026 Oscarsborg Symposium gathered leaders and experts from business, government, and research to examine the critical roles and conditions of busi ...
PRIO awarded funding for new research on the future of peaceful politics
PRIO Research Professor Håvard Hegre has been awarded a prestigious Hernes-CAS Mobility Grant to develop a new research project exploring whether the l ...
Francis Halzen wins Nobel Prize in physics for work on high-energy neutrinos from space
The 82-year-old scientist, originally from Belgium, is affiliated with the University of Wisconsin–Madison. His research into capturing neutrinos at the South Pole dates back to the 1980s.
Fitter Kids May Grow Into Less Depressed Adults
By Dennis Thompson HealthDay ReporterTUESDAY, Oct. 6, 2026 (HealthDay News) — Kids who run and play will reap mental health benefits into middle age, a new study says. Active, fit children appear to have a lower risk of developing depression in their late 30s and 40s, researchers reported recently ...
Nobel Prize in Physics awarded to Francis Halzen for ice research
Scientist Francis Halzen won the 2026 Nobel Prize in Physics, the Royal Swedish Academy of Sciences in Stockholm announced on Tuesday.
Dave McCormick dreams of strengthening science, but Trump is researchers’ worst nightmare
The Pennsylvania senator’s gentle advocacy for NIH funding has had little apparent impact on the president he wholeheartedly supports.
In Race With U.S., China Struggles to Recruit Foreign A.I. Researchers
China’s booming artificial intelligence sector has given local researchers good reason to remain in the country, but it has yet to lure overseas scientists despite a government push.
3 science-backed ways to help your brain clear out waste
If the brain’s plumbing doesn’t work properly, research shows, cellular garbage accumulates, and a cleaner brain may be a healthier one.
41st Great Sports Legends Dinner Supports Neuroscience Research at The Miami Project to Cure Paralysis
The 2026 Legends Dinner honored 11 athletes and announced a $1 million gift supporting drug discovery and The Miami Project’s research.
In this hospital, pulse oximeters went from overestimating to underestimating blood oxygen. Why?
Researchers found pulse oximeters went from overestimating blood oxygen levels to underestimating them; inaccuracies were worse in patients of color.
Science Just Revealed the Worst Way to Eat a Meal (And You Probably Do It Every Day)
Eating the exact same meal alone is less healthy than eating it with other people, new research warns.
Nobel Prize in Physics to Be Awarded in Stockholm
STOCKHOLM (AP) — The Nobel Prize in physics will be announced Tuesday by the Royal Swedish Academy of Sciences in Stockholm. Last year, three scientists won the Nobel Prize in physics for research on the strange behavior of subatomic particles called quantum tunneling that enabled the ...
As federal grant cuts hit social sciences, McInnis ‘worried’ about funds
Yale’s federal funding declined by 1.5 percent in the last fiscal year, with cuts affecting social science fields — which the Trump administration has targeted. Yale President Maurie McInnis said last month that the government had been slow to disburse awards.
Salsa classes seek to spread Hispanic culture, boost campus life
The free weekly dance classes are at 1 p.m. Thursday in the Science and Engineering Innovation and Research Building.
Nature recognized as key component of lifestyle medicine and health
The American College of Lifestyle Medicine (ACLM) today welcomed a resolution adopted by the Association of Fish and Wildlife Agencies (AFWA) that recognizes nature's role in supporting human health and calls for greater collaboration among the conservation, healthcare and research communities.
CREO Brings AI, Health, National Defense Into Focus for Cybersecurity Awareness Month
The Center of Excellence in Cybersecurity Research, Education and Outreach is marking Cybersecurity Awareness Month with a speaker series that runs through Oct. 29.
Political orientation and institutional trust emerge as key factors in local wind energy support
Why does the expansion of wind energy sometimes meet with local resistance, even though renewable energy generally enjoys broad support? RIFS researcher Jörg Radtke used a representative survey of 6,284 ...
Science starts at the dinner table: Building STEM connections with families
By inviting children, parents and grandparents to explore science together, a Hartford outreach program is helping families see research as part of everyday life.
Scientists finally see how nature moves energy so efficiently
Researchers have captured key steps in a chemical reaction that helps nature transfer energy with remarkable efficiency. Ultrafast X-rays revealed how changes involving electrons and protons are closely linked to the rearrangement of surrounding water molecules. Because similar reactions drive photosynthesis and other energy-conversion processes, the technique could help scientists develop better catalysts, fuel cells, and flow batteries.
New Editorial Calls for Investing in Hospital Nursing Workforce to Address Health Impacts of Extreme Heat
Hospitals should make nurse staffing and supportive nurse work environments a core part of extreme heat emergency preparedness, according to a new editorial from Penn Nursing’s Center for Health Outcomes and Policy Research (CHOPR), as record-breaking temperatures and heat-related emergency department visits continue to rise across the United States. The editorial appears in Public Health Nursing.
UW-led optoelectronic center receives second round of funding from the US National Science Foundation
A University of Washington-led center for optoelectronics — technologies that combine light and electronics — brings researchers from 14 universities across the U.S. together with the mission to develop new materials to transform information technology with light. Founded in 2021, NSF IMOD has received a second round of funding from the NSF to continue its work for the next five years.
The Hunt for Consciousness Is Moving Deeper Into the Brain
A research team is using ultrasound to map the deep-brain circuits that may give rise to conscious experience.
Marfan Foundation Convenes Global Scientists in Barcelona to Advance Research on Marfan, Loeys-Dietz, VEDS and Related Conditions
The Marfan Foundation brings scientists from 23 countries to Barcelona to share research that may lead to new treatments and better quality of life for people with Marfan, Loeys-Dietz and VEDS.
Kyoto Vision Rallies 17 Nations for AI-Powered Science: No Budget, No Binding Vows
Kyoto Vision for a Golden Age of Science: 17 nations including the US, Germany, Japan, and South Korea endorsed an AI-driven research declaration at the STS Forum in Kyoto, committing to closed-loop AI labs, reformed science funding, and talent cultivation -- but only to endeavor, not to spend or
Physicians Committee Applauds New Guidance on Animal Use From the National Cancer Institute
In August, the National Cancer Institute (NCI) at the National Institutes of Health (NIH) published new guidance on grant applications for studies involving animal experiments. This guidance requires researchers to justify their use of animals in the publicly available abstract section of applications and encourages them to use human-based methods.
Did New Science Board Just Shift BioCryst's (BCRX) Investment Narrative?
BioCryst Pharmaceuticals recently formed a seven-member Scientific Advisory Board made up of experienced rare disease and drug development leaders to guide its research, clinical plans and regulatory approach. The depth of this board, spanning big pharma R&D, AI driven drug discovery and rare disease commercialization, directly targets BioCryst’s execution risk as it builds a broader pipeline beyond its current portfolio. We will now examine how BioCryst Pharmaceuticals’ investment narrative...
Childhood Housing Assistance Linked to Better Health Decades Later, Children's Mercy Study Finds
A child’s home may shape their health well into adulthood. New research led by Dr. Jeffrey D. Colvin, pediatrician, health services researcher and principal investigator at Children’s Mercy found that children who receive housing assistance are significantly less likely to develop diabetes and high blood pressure, also known as hypertension,...
Blue Turf Thinkers: Biomedical Research Institute investigates harmful diseases
At each Boise State home football game, the “Blue Turf Thinkers” series honors outstanding groups...
University of New Haven Researchers Advance Health Equity and Health-S
Research focused on health equity and health-system transformation has grown from a 2023 faculty-student project into a broad, collaborative body of scholarship involving students, faculty, health sys
Health services may be missing the link between alcohol problems and eating disorders, study suggests
A review led by Bournemouth University researchers has highlighted the extent to which people seeking help for alcohol problems may also be struggling with a second, hidden problem with food and eating. ...
Lightsaber-like plasma antenna uses laser-ionized air to transmit radio waves
Researchers have demonstrated a technique that uses a laser to produce a plasma beam antenna capable of transmitting radio waves. The article, "Laser-Induced-Plasma-Filament Antenna Transmitting 30 MHz ...
Inaugural Delbert E. Day Lecture to be held Oct. 15
The first Delbert E. Day Lecture on Glass Science and Technology will be presented by Dr. Claudio Mazzali, vice president of global research at Corning, Inc. The title of his lecture will be “Precision at Scale: Navigating the Science-to-Factory Continuum that Reshapes Industries for Glass Manufacturing and Beyond.” The lecture will be held at 3:30...Continue Reading Inaugural Delbert E. Day Lecture to be held Oct. 15
1.2K views · 22 reactions | Nobel Prize 2026 explained: the...
Nobel Prize 2026 explained: the breakthrough that lets scientists switch brain cells on and off with light. Known as optogenetics, this technology helps researchers map the brain and uncover the...
Astronomers discover possible planet born from a dead star’s ashes
A second-generation planet might be orbiting a white dwarf, in an astronomy first, according to new research.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine has been awarded to three scientists whose work led to a tool that uses light to help unravel how the brain works
The Science Enabling a Steady Supply of Critical Minerals
Researchers are collaborating across disciplines to unlock domestic sources of valuable materials and lower costs.
Scientists seek new ways to protect Sierra Nevada meadows
Sierra Nevada meadows may cover a relatively small portion of the landscape, but scientists say they play an important role in supporting wildlife, storing water and maintaining biodiversity. Researchers and conservationists recently gathered at the...
3 scientists share Nobel Prize in Physiology and Medicine for work in optogenetics
The Nobel Foundation awarded its prize in physiology and medicine Monday to three scientists who researched how nerve cells affect the brain.
Livelong Women’s Health Summit Builds Momentum for 2027 Expansion
The Livelong Women's Health Summit brought together consumers, clinicians, researchers, and health experts for conversations spanning menopause, strength and performance, brain health, nutrition, hormones, and the science of aging. The Health & Fitness Association (HFA) served as a sponsor for the event.
Science in French? Bien sûr!
As English dominates the publication landscape, support for French-language research is a strategic investment in the quality, equity and the future of knowledge.
Should Aging Be Called a Disease? Scientists Are Rethinking What It Means to Grow Older
What if the next big target in medicine is getting older itself? Researchers are taking that possibility seriously, with new tools, new clinics, and growing FDA attention. Instead of waiting for diabe...
Windows malware uses Grok AI to help stay hidden, researchers say
x47.c Windows malware uses xAI's Grok to maintain persistence on infected PCs while stealing passwords, browser cookies and API keys from victims.
Do More Steps Mean Better Mental Health For Teens?
By HealthDay Staff HealthDay ReporterMONDAY, Oct. 5, 2026 (HealthDay News) — A teenager's daily step count may improve more than their physical health — it may also help protect their mental health. Researchers tracked more than 5,500 adolescents (average age: 12), using Fitbits, brain scans and ...
Sphere Entertainment (NYSE:SPHR) Downgraded by Craig Hallum to "Hold"
Craig Hallum lowered Sphere Entertainment from a "buy" rating to a "hold" rating and set a $132.00 price objective for the company. in a research report on Monday.
Chimpanzees steal less pineapple from their friends
The new research sheds more light on the evolutionary origins of friendship.
The Science Behind Female-Specific Firefighting PPE
Camilla Callesen, chief designer at VIKING Fire & Rescue, and retired firefighter Kendall Taylor discuss the research, engineering, and field testing behind the VIKING VALKYRIE.
Tracking health misinformation helps pediatricians provide targeted patient education
Pediatric clinicians can learn useful information by tracking the health misinformation that their patients encounter, according to research presented during the American Academy of Pediatrics 2026 National Conference & Exhibition Oct. 2-6, 2026, at the San Diego Convention Center.
Digital Science appoints Charlesworth as strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector
Digital Science has appointed Charlesworth as its strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector. This collaboration aims to support the growing demand for research data and information across this rapidly developing market.
Scientists generate identical photons at the push of a button
Researchers from different universities have teamed to generate photon pairs that are 90 percent identical, helping advance quantum communications.
ACSH in the Media: Yahoo News, RealClear, Science & Culture, and More
From cancer and cannabis to perverse research incentives, we’ve been busy confronting nonsense. Here’s a roundup of recent media appearances and pickups featuring ACSH experts across the web, including coverage in Yahoo News, RealClearHealth, RealClearScience, and Science and Culture.
Collaborating with Canadian Scientists on Marine Carbon Dioxide Removal Research
I first met Dr. Helen Gurney-Smith in fall 2024, when Dr. Shannon Meseck and I drove just beyond the U.S.-Canada border to the St. Andrews Biological Station in New Brunswick. We went there to study larval sea scallop respiration when exposed to near-future temperature and pH. This past winter, Dr.
Research Shows These 10 Diets Are Linked to Healthier Aging
A new study found that many different diets can slow biological aging.
Anthropic AI agent uses human scientists as tools, emails 1,500 without instructions
ColonistOne, built on Claude Opus, autonomously contacted researchers to troubleshoot bugs and seek methods, raising concerns over academic spam and AI autonomy
What Holding Eye Contact While Someone Speaks Really Reveals About Your Psychology, According to Science
You are mid-conversation with a friend, nodding along, and suddenly you wonder: am I looking at them too much? Or not enough? Most of us treat eye contact like an automatic reflex – something we either do or don’t, without thinking twice. But researchers say the way you hold someone’s gaze while they speak is...
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Assembly praised their method, noting its global use in revealing brain mysteries.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Assembly praised their method, noting its global use in revealing brain mysteries.
UConn Scientists’ Startup Seeks to Advance Women’s Reproductive Healthcare
'Historically, women’s health has received insufficient attention in medical research and testing'
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine was awarded Monday to three scientists working on the mechanisms the brain uses to switch on, or off, the activity of individual nerve cells.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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