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Mental health grant cancellations at issue in new lawsuit from 15 states
The attorneys general say the department plans to terminate the grants despite a prior injunction protecting them.
The Independent Retailer Built on Prioritising Black Buying Power
James Whitner’s multibrand business, which includes stores like A Ma Maniére and Social Status, is manoeuvring through a tough retail environment by serving Black communities that fashion has traditionally overlooked.
AMC Entertainment (AMC) Registers a Bigger Fall Than the Market: Important Facts to Note
AMC Entertainment (AMC) closed at $1.87 in the latest trading session, marking a -1.06% move from the prior day.
Luka Dončić Pushed for Lakers’ Move to Acquire Walker Kessler
The superstar point guard prioritized Kessler’s elite rim protection, leading Los Angeles to sacrifice massive future draft capital and $130 million to secure his ideal pick-and-roll partner.
Microsoft announces major Windows 11 search overhaul that prioritizes clearer, local results, and removes ads: Huge effort to fix search on Windows is finally happening
Windows 11's search user experience is getting a big update, with Microsoft moving to prioritize local results, remove promotional content, and much more.
Delaware expands payer and provider HIE access under RHTP
With an eye toward prior auth and insurance verification, the First State is using some of its Rural Health Transformation funding to broaden access to the health information exchange, reduce administrative workloads and enhance data usability.
NJBIA Op-Ed: NJ’s Low CNBC State Business Rankings Are a Call to Action
NJBIA President and CEO Michele Siekerka, in an op-ed published Monday in BINJE, is urging state leaders to make predictability a top priority for
The ‘Palworld’ Stats To Level First, Those To Ignore And How To Respec
Here are which stats should be a priority to upgrade in Palworld, which ones to avoid for a while, and how to respec the skill points.
Decadal Survey for Earth Science and Applications From Space Seeks Input
The newly launched decadal survey for Earth Science and Applications from Space (ESAS) is seeking input on future priorities and…
AB Science ends three studies in multiple sclerosis, other immune conditions
The trials, which were testing the tyrosine kinase inhibitor masitinib, had previously been paused. AB Science’s decision not to resume them was a matter of prioritization, not safety, the biotech said.
These Knoxville programs lift up Black business owners. You can too
The Knoxville Area Urban League president and CEO has prioritized growing resources for Black entrepreneurs.
Handover of Health Commodities
Joint Handover of Health Commodities Speech of Chargé d’Affaires Steve Bremner (…) Thank you for joining us. I am here today to demonstrate how U.S. foreign assistance under President Trump’s America First Global Health Strategy and our bilateral health MOU makes America safer and stronger while helping Madagascar build a more self-reliant health system. Through our bilateral Global Health Memorandum of Understanding (MOU) signed in December 2025 with the Ministry of Public Health, our two governments outlined shared priorities and responsibilities, including a strong focus on infectious disease threats and Madagascar’s increasing ownership and co-investment in its own health system. The MOU outlines the structure and terms of U.S. support to Madagascar’s health sector from 2026 through 2030, with a total commitment of $134,305,000 from the U.S. government and $41,216,252 from the Government of Madagascar to work jointly to address malaria, maternal and child health, polio and global health security issues. Stronger health systems help prevent instability and reduce the risk that infectious diseases reach the United States, making both our countries safer. America First foreign assistance is clear and disciplined: It is a tool of strategic engagement, not global charity. Every U.S. taxpayer dollar must show measurable results, reduce long-term dependence on U.S. taxpayer resources, and support greater self-reliance in recipient countries. Support must be efficient and targeted, with zero tolerance for fraud, waste, or abuse. This year, through the U.S.-funded Global Health Supply Chain Program – Procurement and Supply Management project, we are distributing: 989,250 long-lasting insecticide-treated nets, worth $2,000,000 to 63 districts and 1,661 Community Health Centers across Madagascar, with the third and final delivery of these nets having arrived in late June. Through the U.S.-funded Momentum Country and Global Leadership (MCGL) project, we are funding: The full cost of Starlink internet connectivity equipment procurement, installation, and one-year subscription for 31 priority District and Regional Health Offices. Through the U.S.-funded Strengthening Infectious Disease Detection Systems project, we are supplying: 908,523 pieces of critical medical equipment and a modernized digital surveillance system to the Ministry of Public Health. These materials will strengthen health systems, improve response capabilities, and help those most in need of protection from mosquito-borne diseases — particularly malaria, which continues to claim the lives of children and women at an unacceptable rate. Deployed effectively, they will contribute to reducing maternal and newborn mortality in rural and hard-to-reach communities where the need is greatest. In these same underserved areas, Starlink connectivity will play a critical role in enabling the rapid transmission of health data and information to central levels, ensuring that decision-makers receive timely, actionable intelligence and can mount swift, coordinated responses to protect populations. For Americans, this support delivers concrete benefits. Stronger health systems in Madagascar help detect and contain infectious diseases before they spread across borders, protecting American and Malagasy families. More stable, healthier countries can expand trade and economic cooperation with the United States. Our goal is not permanent support; it is temporary, targeted assistance that helps Madagascar save lives while achieving greater self-reliance and independence from foreign assistance. To the health workers and community health agents here that will use the products we’re delivering today: your dedication and skills save lives. Your work exemplifies the kind of local ownership that will enable Madagascar to reduce dependence on foreign assistance and manage the country’s health challenges. This targeted support delivers results today while helping Madagascar build toward a future where it can sustain and expand those health gains independently, ensuring that today’s U.S. support leads to Madagascar’s self-sufficiency. Thank you, Misaotra.
United States Delivers Life-Saving Health Supplies and equipment to Madagascar
United States Delivers Life-Saving Health Supplies and equipment to Madagascar U.S. Chargé d’Affaires Steve Bremner presided over a handover ceremony to the Government of Madagascar, represented by President of the Refoundation Col. Michaël Randrianirina, marking the delivery of nearly one million mosquito nets, over 900,000 pieces of critical laboratory equipment, and 33 internet connectivity systems. The assistance – valued at more than $2.2 million – is part of a broader U.S.-Madagascar health partnership, outlined in our bilateral Global Health Memorandum of Understanding (MOU) signed in December 2025, totaling $134 million from the U.S. government from 2026 through 2030. “This assistance is clear and disciplined – it is a tool of strategic engagement, not global charity,” said Chargé d’Affaires Steve Bremner. “Every U.S. taxpayer dollar must show measurable results, reduce long-term dependence on U.S. resources, and support greater self-reliance. Stronger health systems in Madagascar help detect and contain infectious diseases before they spread across borders, protecting American and Malagasy families alike.” The assistance includes: 989,250 long-lasting insecticide-treated mosquito nets - worth $2 million – will be distributed to 63 districts and 1,661 community health centers across Madagascar. Malaria remains one of the leading causes of death in the country, claiming the lives of children and women at an unacceptable rate. The third and final delivery of these nets arrived in late June and will be distributed starting this July until mid-October, ensuring that those most at risk of mosquito-borne disease now have access to this basic but life-saving protection. U.S.-funded Global Health Supply Chain Program – Procurement and Supply Management (GHSC-PSM) project will ensure the distribution. 908,523 pieces of critical medical and laboratory equipment – valued at $180,000 – including personal protective equipment, laboratory supplies, diagnostic tools, and cold chain equipment – along with a modernized digital surveillance system to Madagascar’s Ministry of Public Health. This support through the STRIDES (Strengthening Infectious Disease Detection Systems) program bolsters Madagascar’s ability to detect and respond to outbreaks of diseases such as monkeypox, plague, rabies, polio, and Ebola before they become regional or global threats. Over $30,000 of funding for the full procurement, installation, and first year of service for 33 Starlink satellite internet systems at priority districts and regional health offices across the country. These systems will allow health workers in remote and underserved communities to transmit health data quickly to central decision-makers – enabling faster, better-coordinated responses when disease outbreaks occur. U.S.-funded Momentum Country and Global Leadership (MCGL) will implement this project. As the country’s largest bilateral health donor, the United States remains committed to the principle that a stronger, healthier Madagascar makes for a stronger, safer world – and a stronger, safer America.
Lindsey Graham remembered for a vision of American foreign policy that’s fading in Washington
Graham was a rare bridge between President Donald Trump’s “America First” foreign policy and the traditional Washington consensus prioritizing alliances with Europe and Israel, one falling out of favor with many in both political parties.
Dana White offers bizarre defense of Conor McGregor’s health status by citing social media views
UFC CEO Dana White got a bit defensive after accusations surfaced on Saturday night that star fighter Conor McGregor, who was making his return to the octagon after a five-year absence, had been injured prior to his fight with Max Holloway to headline UFC 329 in Las Vegas. McGregor lost to Holloway via TKO 69…
Sac County sheriff criticizes CA crime policies, calls for victim-focused reforms
With about a month left for California lawmakers and the governor to pass new laws for the year, Sacramento County Sheriff Jim Cooper voiced frustration over the state's crime policies, citing issues with mental health diversion, domestic violence laws, and funding for Proposition 36, while urging lawmakers to prioritize victims' rights.
Prioritizing Women’s Brain Health Can Save Lives and Global Economies
Prioritizing Women’s Brain Health Can Save Lives and Global Economies
Assassin's Creed Black Flag Resynced opens to 2 million sales on launch day
Ubisoft tends not to share sales figures publicly – which means we can't even compare it to the sales of prior Assassin's Creed games, let alone its peers.
The EPA promised a MAHA agenda. It has yet to materialize, frustrating activists
After Make America Healthy Again activists drew up a petition to get him fired, EPA administrator Lee Zeldin pledged to release a formal agenda of MAHA priorities his agency would pursue. But eight months after its first mention, the so-called MAHA agenda is nowhere to be found.
Alaska governor vetoes new limits on political donations
Alaska Gov. Mike Dunleavy on Thursday vetoed a bill that would have reimposed limits on the amount of money that individual people can donate to political candidates. The 9th U.S. Circuit Court of Appeals overturned Alaska’s prior limits in 2021, and the Dunleavy administration declined to appeal the decision. Alaska has been without limits on […]
EPA promised a Make America Healthy Again agenda. It has yet to materialize, frustrating activists
After Make America Healthy Again activists drew up a petition to get him fired, Environmental Protection Agency administrator Lee Zeldin pledged to release a formal agenda of MAHA priorities his agency would pursue.
The best recent science fiction, fantasy and horror
Sublimation by Isabel J Kim; Last Day of a Prior Life by Andrés Barba; Dead But Dreaming of Electric Sheep by Paul Tremblay; The Carrier by Ruth Newton; Time to Burn by Ellery Lloyd
Scientific Merit, Not Political Priorities, Should Guide Research Stewardship
The proposed OMB changes to research funding threaten US science. Researchers must stand up for and share the value of science to society.
Penguins sign second-rounder Tomas Galvas
In two prior NHL drafts, all 32 teams passed on Czech defenseman
Warriors Top Backup Plan For LeBron James Falling Apart
The Golden State Warriors are running out of options with difficult paths towards acquiring their ideal names. LeBron James remains the dream scenario to join them in free agency and unite with rival Stephen Curry for the first time in their NBA careers. Unfortunately for Golden State, it appears that LeBron is prioritizing the Cleveland […] The post Warriors Top Backup Plan For LeBron James Falling Apart appeared first on HEAVY.
Cardinal Health to Announce Fourth-Quarter and Year-End Results for Fiscal Year 2026 on August 11
Cardinal Health (NYSE: CAH) plans to release fourth-quarter and year-end financial results for its fiscal year 2026 on August 11, prior to the opening of trading on the New York Stock Exchange....
World Cup betting surge fuels renewed push to legalize sports wagering in Texas
With the Texas Legislature set to return in January for their regular session, sports betting advocates are hoping lawmakers prioritize the topic.
World Cup betting surge fuels renewed push to legalize sports wagering in Texas
With the Texas Legislature set to return in January for their regular session, sports betting advocates are hoping lawmakers prioritize the topic.
Packers, Network Health partner for Operation Fan Mail in 2026
Program recognizes military families and veterans at Lambeau Field prior to kickoff
Northern Virginia business optimism rebounds in Q2 as layoff fears hit lowest point in survey's history
18% of respondents are based in Alexandria; tax reduction and right-to-work top policy priorities for Spanberger and General Assembly
Hungary moves to overhaul university models banned from Horizon Europe
Hungary’s new government is aiming to overhaul the governance model of the institutions and universities that lost access to Horizon Europe and Erasmus+ funds “in a short timeframe,” according to Péter Horváth, the new state secretary for science policy and innovation. “As of today, the two non-university foundation-controlled institutions under my remit have been transformed,” he told Science|Business. “We hope the universities will follow and that this will be enough to satisfy the EU’s demands.”Under the previous government, led by Viktor Orbán and his Fidesz party, many academic and scientific institutions were restructured and made into special public trust foundations, with members strongly linked to the government given lifelong mandates and significant decision-making powers with little oversight. The European Commission deemed that this undermined academic freedom and transparency in the country, leading to a ban on 34 institutions in 2022, including 21 universities, which saw academics in Hungary lose access to Horizon Europe grants. The new Hungarian government, elected in May and led by Péter Magyar and his Tisza Party, has promised to dismantle this governance model and restore the institutions to EU programmes. As a result, the European Commission has promised to return access to the Erasmus+ education mobility programme, but so far no concrete agreement has been made on the Horizon Europe programme for research and innovation. Hungary has already made legislative changes in June to allow the institutions to be reformed and set a timeline for the implementation.The non-university foundations, which are mainly cultural centres such as the Foundation for Hungarian Culture or the Makovecz Campus Foundation, will all be dissolved by August 31 this year, a date tied to EU-set milestones that Hungary must meet to unlock frozen funds, with control transferred to relevant ministries. Meanwhile, the universities will have until 31 August 2027. For each university foundation, the government will set the dissolution date and the body to take over operations. There is no final decision on a permanent new model for the universities, according to Hungarian MEP Eszter Lakos, who is shadow rapporteur for the Horizon Europe specific programme, a separate piece of legislation detailing implementation rules for the EU’s next research programme, due to start in 2028. “The aim of the transition year is to settle this with [the universities], not to impose a model, and not to put them under state control,” she told Science|Business. “The goal is to give academic independence back to universities.”There are three models that are most likely to be implemented. One would be a return to a traditional, state-run model. Another could be a newer, more self-standing public institution. A third option would be a reformed version of the foundation models that meet EU standards. According to Lakos, the dismantling of the system put in place by the Orbán government is well underway and if all goes according to plan, Hungary could regain access to EU research money by the start of the next academic year in 2027. “I believe that the Hungarian government is doing the necessary changes so the universities could return as beneficiaries to Horizon from the next school year,” she said. In the meantime, “the universities, institutes and cultural assets carry on under proper public stewardship rather than a handful of unaccountable trustees,” said Lakos. The laws passed in June impose new safeguards: board terms are capped at four years and renewable only once, appointments are made through open competitions and sitting politicians cannot join joining these boards.It remains unclear whether a domestic science funding programme set up as a back-up scheme by the former government following the EU funding ban, called HU-rizon, could be continued. “This programme should never have had to have been established in the first place, but it has proven to be quite popular,” he said. “I am considering continuing this programme with a refined focus on helping international collaborations.”Re-organising the research network One of the first priorities for Horváth and his cabinet is to resolve questions over the future of the Hungarian Research Network, Hun-Ren. The network of academic institutes was taken away from the Hungarian Academy of Sciences in 2019 and turned into a quasi-private organisation, with similarities in its governance to the public trust foundations.Horváth and his team have consulted over 5,000 representatives from the network and the conclusion is broad unhappiness with the directors of all the institutes involved. “We have presented the results to the president and the chief executive of the network and this is currently being discussed,” Horváth said. The plan is to re-integrate the network back into the Academy of Sciences but in an improved way, “learning from mistakes of the past,” he added. The government also wants to reintegrate four humanities and social science research centres into the network that the previous government had transferred to Eötvös Loránd University. The transfer brought sharp criticism from the academic community, with a group of Hungarian research heads, including European Research Council grant recipients, sending an open letter to Orbán warning that the transfer would “cause historically significant harm to the entirety of Hungarian scientific life.” The transfer was “one of the biggest shames in Hungarian research in the past 20 years,” Horváth said. “We want to immediately re-integrate them back into the research network and to regain the trust of these institutions, because the way they were treated was really unfair.”Another pressing issue is the Élvonal Excellence Research and Talent Development Foundation, led by Nobel laureate Ferenc Krausz. The foundation signed a financing agreement with the former government earlier this year for a budget of over €730 million over the next five years. The goal is to create a world-class centre to attract top talent from abroad and to develop local researchers. But there was little transparency about this foundation, and news of its huge budget, which is nearly as much as Hungary’s entire research budget, caused a stir in the media following the recent elections. Another issue is that, as with the foundation boards of the institutes banned from Horizon Europe, there was little-to-no oversight of decisions led by Krausz. “It was an excellent idea but an unacceptable execution,” Horváth said of the foundation. “The fact that this is out of the Hungarian funding scheme, mostly concentrating on one person who decides on the budget is unacceptable for us.”The government plans to merge the centre with the National Research, Development and Innovation Office, the country’s R&D funding agency, with a reduced budget. Horváth is hopeful that Krausz will still be involved. The new government’s R&D goalsA phrase that crops up regularly during the discussion with Horváth is “democratic process.” The new state secretary is determined to involve Hungary’s research community in shaping future policies. This marks a departure from the previous government’s approach, and several people in Hungary’s research community have commented on the openness of the new government. In terms of concrete goals, Horváth and his team already have plans. He wants to create a new science fund in Hungary, based on the best practices of other European countries. The fund would not be tied to annual government budgets and would provide long-term, stable financing. “If we were to succeed in creating this fund, then I think it would be one of the biggest achievements for me in this period of government,” Horváth said. On the innovation side, he is looking into how best to bring in the private sector. “We want to make sure that we are working with the private sector to support innovation,” Horváth said. One of his big aims is to introduce entrepreneurship teaching into high schools. Hungary already has a reputable national academy offering research and innovation training in the field of natural sciences, and Horváth wants to expand this to all disciplines and across the whole country. “One of the main ways to elevate our innovative businesses is to teach our children to be innovative,” he said. “This will probably need ten years to pay off, but this is what we should do. Our aim is to make Hungary strong in our region, and this is what is needed.” Related articlesHungary’s Horizon Europe performance in numbersCommission unlocks Erasmus+ cash for Hungary, Horizon could be next‘Academic Huxit.’ Hungarian researchers speak out on impact of EU ban A more difficult task will be funding. The new government is aiming to increase research spending to 2% of the GDP by 2030, and then increase it to 3% in line with EU objectives. Currently, spending sits around 1.3%. But according to Horváth, the current budget, inherited from the previous government, is “heavily in the negative,” so any plans to increase research spending will have to start next year. Achieving 2% by 2030 already needs a big push, almost doubling the research budget. “This is something we’d definitely like to reach, and something I can see us achieving,” he said. “From the 2030s, I’d like to see an innovative generation growing up that can help us reach the 3% target.” Positivity in the new governmentDespite the many challenges facing Horváth and his team, the mood is positive. “It feels a bit like a start-up right now. Everyone is working 24/7, day and night, trying to do as much as they can. There is a lot of energy,” he said. It is a big change for the state secretary who, like many in his cabinet, is coming from a background in research or business, and not in politics. “Six weeks ago, I was sitting with my microscope and my research PhDs, so it’s been a big change for me,” said the computer scientist, who was previously the director of the Institute of Biochemistry at the Hun-Ren Biological Research Centre in Hungary and worked at the Institute for AI for Health at Helmholtz Munich. But he is relishing the task to transform the country’s R&D landscape. “We feel enormous support from the Hungarian people, but also from Europe,” he said. “We’ve received a lot of letters of support from around Europe. There is big trust there, and huge responsibility on our side. We want to get everything back on track, and there’s a lot to do.”
Trump weighed in on Cabinet squabble over ride for July Fourth flyover
The president encouraged acting attorney general Todd Blanche to fly on one of NASA Administrator Jared Isaacman’s jets despite the FAA’s prior objection to the planes.
Titan OS adds 30 Radial Entertainment FAST channels in Europe
Titan OS is adding and expanding reach of 30 free ad-supported streaming TV channels from Radial Entertainment’s FilmRise to its smart TV OS-powered device footprint across Europe. | Expansion of FilmRise channels internationally is currently a top priority for Radial, the company said.
As Israel becomes Democratic litmus test, Jewish progressives warn about a tilt into antisemitism
For many liberals, longtime policy priorities like universal healthcare or stopping climate change are now intertwined with opposing Israel. An ascendant faction of the left argues there’s no such thing anymore as “progressive except for Palestine” — a phrase that took off in the years following Hamas’ October 7, 2023, attack and the ensuing war in Gaza — and sees opposition to Israel as a Democratic litmus test.
Indiana Fever End Nine Years of Frustration With First-Ever Las Vegas Win
Prior to Sunday's game, the Indiana Fever were 0-11 against the Aces in Las Vegas in the regular season.
Everything New in iOS 27 Beta 3
Apple is continuing to refine iOS 27 ahead of its planned September launch, and the third beta includes several new features. Siri is more customizable, there's a fun new wallpaper action, and some useful improvements to Photos and Shortcuts. Siri Voice Beta 3 adds support for Siri voice customization on compatible devices. The customization option existed in prior betas, but it was not active.
Newly Launched Initiative Strengthens Delaware’s Health Information Technology Infrastructure
The Delaware Department of Health and Social Services (DHSS) and the Delaware Health Care Commission today announced a new Rural Health Transformation Program (RHTP) initiative that will support real-time insurance verification and prior authorization across the state.
Trump-Republican infighting hands the Democrats a chance
Republican senators increasingly spar with a president who they see as too focused on his own priorities at the expense of their reelection prospects.
Apple Silicon Exec Explains Mac Mini AI Demand and On-Device Future
Apple's Mac mini and Mac Studio have become the machines of choice for running AI agents, according to Doug Brooks, Apple's senior product manager of Apple silicon. Brooks made the claim while discussing Apple's chip strategy in a newly published interview with The Deep View conducted just prior to WWDC 2026 in June. Brooks says that the company has seen "incredible demand" for the two desktop Macs.
David Coulthard calls for FIA entertainment focus after British GP ending
David Coulthard has urged the FIA to prioritise entertainment after the British Grand Prix ended anticlimactically behind the safety car
Exclusive: Rural health funds to fix prior authorization
Delaware plans to streamline the insurer pre-treatment claims reviews, widely criticized for delaying timely health care.
Could Santos help solve Man Utd's midfield malaise?
Chelsea's Andrey Santos is the latest player Manchester United have taken an interest in as they look to address their problem midfield position. With Casemiro leaving after his contract expired on 30 June and Manuel Ugarte expected to be sold, United went into the summer with England's Kobbie Mainoo as their only recognised central midfielder and with the stated aim of addressing the situation as a matter of priority. In the transfer market, United have encountered more issues.
Next 48 hours to be decisive for Greenwood’s future
Gian Piero Gasperini has circled Mason Greenwood’s name in red. The English winger is a top priority for raising the level of attack ahead of next season. The 2001-born player already has an agreeme...
Three Under-the-Radar Trade Targets for Philadelphia 76ers
To optimize a star-studded core, the Philadelphia 76ers must prioritize low-usage role players. These three players offer the chemistry and financial flexibility necessary for a deep postseason run.
Orlando Magic's Most Confusing Move in Free Agency
Orlando’s decision to re-sign Jonathan Isaac despite plummeting production and injury history sparks criticism, as analysts question prioritizing loyalty over finding a reliable veteran presence.
Political rivals, Lapid, Edelstein, surprisngly align on national priorities
Both men are defining Israeli politics not through the traditional categories of Left and Right, but through questions of national responsibility, military service, and national consensus.
Oversharing Can Be Dangerous: How Digital Nomads Can Build an Audience While Staying Safe
Use social media intentionally to grow your business by sharing your digital nomad lifestyle authentically while prioritizing safety.
Mavs Should Make Bennedict Mathurin a Priority in Free Agency
The Mavericks want to build around Cooper Flagg for years to come and Bennedict Mathurin’s age and scoring ability align with that timeline.
Dragon Quest 11 S details Nintendo Switch 2 frame rate and resolution
Following up on the recent announcement of Dragon Quest 11 S on Nintendo Switch 2, Square Enix provided more information including frame rate and resolution details. The company previously confirmed that two graphical options will be included. Players can choose between different optimization modes, allowing them to prioritize graphics or performance. When going with Performance Priority Mode, Dragon Quest 11...
Freedom 250 Independence Day Entertainment
Freedom 250 presents events from the National Mall prior to the evening "Salute to America" program.
#PostPulpit mailbag: What are the Patriots’ remaining offseason priorities?
The latest edition of our Patriots mailbag answers questions about the offseason to do list, defensive changes, and more.
Platner will prioritize public health, which Collins helped to dismantle
A new television ad (paid for by “America First International Assistance”) portrays Sen. Susan Collins as protecting Maine from the Ebola virus by funding millions in scientific research. While the ad may have historical truth concerning her record (the footage appears to be several years old), Sen. Collins is a member of the Republican Senate […]
FBI directs hundreds of analysts to probe of Georgia 2020 presidential election
The FBI describes it as a "priority investigation"
FBI directs hundreds of analysts to probe of Georgia 2020 presidential election
The FBI describes it as a "priority investigation"
Why Kotek is directing Oregon to prioritize small business contracts
Oregon small businesses will get preference in state contracting, Gov. Tina Kotek announced. Here's why.
Are You Tracking These 5 Warehouse Metrics? If Not, Here's Why You Should Be.
Many leaders prioritize marketing, customer acquisition and sales channels to scale, but what they really need is hiding in plain sight.
FBI assigns 260 staff members to Georgia 2020 election probe
The FBI has ramped up its investigation into the 2020 election in Georgia by dedicating more personnel to what an internal memo refers to as a “priority,” a person familiar with the matter told CNN.
Oregon’s top public health official resigns
Oregon’s top public health official is stepping down from her role after two and a half years. Dr. Sejal Hathi, who joined the Oregon Health Authority in January 2024, will leave Aug. 1 to focus on family and personal priorities, the governor’s office announced Thursday. Hathi, who earns $265,488 per year, joined the Oregon Health […]
EMA steps up efforts on medicines for women’s health
Initiatives to map gaps, challenges and prioritise further actions
NJ lawmakers approve extra mental health support for schools
New Jersey lawmakers approved a plan to expand school-based mental health services over the coming years, a priority for Gov. Mikie Sherrill, who is expected to sign the bill.
Southern California’s total tobacco bans aren’t helping public health
Instead of pursuing tobacco bans, state health officials should prioritize proven harm reduction policies.
Marion County warns Oregon behavioral health rules put staff, residents at greater risk
KATU ABC 2 offers coverage of news, weather, sports and community events for Portland, Oregon and surrounding towns, including Beaverton, Lake Oswego, Milwaukie, Happy Valley, Gresham, Vancouver, Hillsboro, Oregon City, Tualatin, West Linn, Woodburn, Tigard, Tualatin and Garden Home.
How the Iran War Ignited a Clash Between Trump and the Saudi Crown Prince
Crown Prince Mohammed bin Salman pressed President Trump earlier to cripple Iran. But as Iran asserted its power, the prince urged a cease-fire, and is now pursuing his security priorities.
Private sector added 98,000 jobs in June, below expectations, ADP says
The figure reported on Wednesday is below economists’ estimates of an increase of 118,000 jobs. The prior month's reading was unrevised at 122,000.
Sony will cease production of discs for new PlayStation games in 2028
New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?
Marketers pivot to TikTok, YouTube to target Gen Z shoppers
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Xbox ends deal to fund and publish IO Interactive's Project Fantasy; redundancies expected
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Affordable Healthcare Emerges as a Voter Priority in Purple Nevada
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How a new super PAC formed to counter AIPAC is fueling democratic socialists’ wins
American Priorities, which started just six months ago, has quickly emerged as an influential force in House Democratic primaries, spending at least $5.6 million to boost Democrats who are fiercely critical of Israel. It helped democratic socialist Melat Kiros defeat Colorado Rep. Diana DeGette on Tuesday.
WATCH: Angel mom turns tables on sanctuary politicians with basic question about their priorities
Jessica Gorman told lawmakers her daughter Sheridan “was not a talking point" as she accused sanctuary city leaders of failing to protect American citizens.
Records show prior mental health petition for man accused of killing grandmother in Farmington Hills
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Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Longtime Clinton aide walks back claim former president visited Epstein island, sources say
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Decrying 'egos in politics,' Wu sharpens attacks on Beacon Hill foes
Mayor Michelle Wu's deteriorating relationships in the Senate have led her to drop the veil and endorse first-time candidates running against those whom she views as thwarting her priorities.
‘Grateful and humbled’
MARSHALL — Two individuals who played important roles in building the Marshall baseball program into one of the state’s best were honored Sunday evening with induction into the Marshall Baseball Hall of Fame. Steve Fleck and Blaine Schnaible became the 20th and 21st members of this select group during a pre-game ceremony prior to the […]
Chiefs Honor Former Running Back Joe Delaney on Death Anniversary
Kansas City missed the playoffs for the first time in the Patrick Mahomes era last season, finishing 6-11. Before last season, Mahomes had led the Chiefs to at least the AFC championship game every year prior.
Gov. Laura Kelly surveys landscape as she exits government service, points to unfinished business
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Cornell Yang Center for Wildlife Health awards seed funding to five conservation efforts around the globe
The CCF provides catalytic seed funding to spark pioneering applied research to advance wildlife conservation solutions. The fund prioritizes initiatives that improve the health of free-ranging wildlife and/or solve environmental problems via a One Health lens.
‘Our goal is compliance and safety’: Brownsville mayor on Midtown Entertainment District shutdowns
Editor’s note: The video above is from previous coverage. HARLINGEN, Texas (ValleyCentral) — In a statement on Sunday, Brownsville Mayor John Cowen said the city’s priority is safety fo…
NEA Nuclear Science Committee advances strategic priorities for the future of nuclear research
The NEA Nuclear Science Committee met on 8-10 June 2026 to advance international collaboration, strengthen scientific expertise, and shape the future of nuclear science through innovation, data and AI.
Doctors urge men to prioritize preventative care during Men’s Health Month
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House committee advances radiology-backed legislation to curb prior authorization
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Jose Mourinho eyes Chelsea mainstay as his ‘priority’ signing
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NI health: Resident doctors begin strike action over pay
The BMA said there will "undoubtedly be cancellation of operations, outpatient appointments and elective care" but "patient safety will still be prioritised".
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Assemblyman David Tangipa says California should spend more on veterans than undocumented immigrants
California Assemblyman David Tangipa shared his views on the state's budget negotiations, focusing on tax increases, spending priorities, and the implications of California's $350 billion budget.
3 Traps Health Systems Fall Into When Trying to Improve Their Culture
Cultivating a positive culture is a priority for hospital leaders, but many are making avoidable mistakes. Myra Gregorian, Seattle Children's chief people and transformation officer, outlined some of these common blunders — such as not involving frontline staff in decision making and assuming that simple communication methods are sufficient.
Again, Trump said nobody left his speech. Again, that wasn’t true
President Donald Trump posted on social media on Thursday about the speech he gave the day prior to kick off the Great American State Fair in Washington, DC: “Everybody stayed right until the end of my Speech because they loved hearing about a truly successful America.”
City of Palms new downtown parking program: How local business react to the change
The Fort Myers City Council recently approved a change impacting parking rates at all three of downtown Fort Myers' parking garages. As it stood, visitors would receive one hour of free parking followed by a hourly rate. Now, the change has made it so visitors are entitled to two free hours followed by a hourly rate. Local business owners and managers said it's a good idea giving visitors more time to bask under the royal palms and indulge in some shopping. But one general manager points out a problem that did not start yesterday, but years prior.
Audio: RFK Jr. urges Libertarian candidate to drop out race to help GOP keep House
OutFront obtains audio of US Health and Human Services Secretary Robert F. Kennedy Jr. urging a Libertarian congressional candidate in Iowa to drop out of the race to improve Republicans’ chances of winning - and keep control of the House. Rick Stewart, who had no prior relationship with RFK Jr., tells Erin Burnett it’s “ludicrous” a Trump cabinet official would make such an offer.
iPhone 18 Pro and Pro Max May See $200 Price Increase
Apple's iPhone 18 Pro models could be up to $200 more expensive, according to a prediction from analytics firm IDC. IDC expected Apple to raise iPhone 18 prices, but prior to yesterday's Mac and iPad price hike, the prediction was a $100 increase for the 18 Pro and Pro Max, and a $50 increase for the base models. IDC Senior Director of Data & Analytics Nabila Popal says the magnitude of the Mac and iPad price increase points to even higher iPhone 18 prices.
GOP senators seem increasingly game to buck some Trump priorities
Is growing pushback from conservative corners of the upper chamber a sign that Trump’s grip on his party may be slipping?
How Trump’s Political Agenda Is Shaped by His Own Obsessions
President Trump’s priorities seem increasingly detached from the concerns of voters and his party.
Commitment season looming as Ohio State staff awaits
The month of June has been a grind for Ohio State’s coaching staff. Position camps, recruiting visits, and still prioritizing their current roster, the Buckeyes have had zero time off… and that will soon change. Ryan Day and company set to be on vacation in the coming days for a well deserved break, that doesn’t […]
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Gillings-supported center helps public health teams prioritize infectious disease risks, from measles to the World Cup - UNC Gillings School of Global Public Health
June 25, 2026 When public health workers prepare for infectious disease threats, the question is rarely whether risk exists. It is where to focus first.
By Refusing to Sign a Bipartisan Housing Bill, Trump Made It Clear That He Doesn’t Care About Everyday Americans
What’s the president’s priority instead? Passing his voter-suppressing SAVE Act to keep his cronies in power.