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Call of Duty: Modern Warfare 4 Beta Struggles To Impress
With more competition than ever, the once immovable military shooter is going to have to earn its stripes, though some fans feel Infinity Ward's adjustments might be over-corrections
Epic Games Store overhaul might be "too little, too late", says Newzoo analyst
Newzoo's Emmanuel Rosier has weighed in on Epic's planned launcher overhaul, arguing Steam's dominance may already be too entrenched.
Letter: Apply science, aloha to solve cat problem
Hawaii must address the impact of free-roaming cats on native wildlife, but it must be done humanely and based on science. Simply restricting feeding is not a viable solution; it risks increasing predation on endangered species and ignores the root causes of the problem. Hungry cats do not disappear — they might hunt more, further threatening native wildlife (“Enact law to curb feral cat colonies,” Star-Advertiser, Our View, Aug. 19). That is not a responsible outcome.
Eye-watering price tag leaks for upcoming Asus Googlebook with 16 GB RAM and 8-core CPU
Courtesy of a leaked listing, we now have a fair idea of just how pricey the upcoming CX9406 Googlebook from Asus might be. Whether or not the new family of glorified Chromebooks live up to the hype remains to be seen.
Analysis: Does defeat foreshadow struggles this season?
When the Crystal Palace players trudged off the pitch, Pierre Sage cut a deflated figure. Saturday afternoon had provided the Frenchman with a brutal introduction to life as a Premier League manager and to the fine margins that can decide games. On another day, perhaps one where Ismaila Sarr was available for selection, it might have been Palace who were dancing and celebrating their way back to the dressing room.
What is the ‘Android Pulse’ app that just appeared in Google Play Store updates?
On Saturday morning, you might have noticed an app called “Android Pulse” appearing in the list of available Google Play updates.
Your Doctor’s Office Might Soon Start Charging an Unexpected Fee
Some physicians say it's a positive thing. Would you pony up?
Healthcare startup Devoted Health could be valued at $25 billion
Devoted Health, co-founded by Ed and Todd Park, is raising a round that might value it at $25B, spotlighting the booming Medicare Advantage sector.
Healthcare startup Devoted Health could be valued at $25 billion
Devoted Health, co-founded by Ed and Todd Park, is raising a round that might value it at $25B, spotlighting the booming Medicare Advantage sector.
Reimagining how scientists study the chemistry of the air
Professor Victoria Barber and doctoral student Cooper Crabtree are spearheading Keck Foundation-funded project charting a path toward better understanding atmospheric oxidation. by Álvaro Castillo, UCLA College of Letters and Science From the vantage point of Victoria Barber, a UCLA assistant professor of chemistry and biochemistry, understanding the chemical reactions that shape air quality and climate are among the most pressing scientific challenges of our time. And thanks to a recent grant from the W.M. Keck Foundation, she and doctoral student Cooper Crabtree will spearhead a new research project exploring exactly how pollutants form in the atmosphere. Specifically, the project will examine how volatile organic compounds transform through atmospheric oxidation and explore how pollutants, like smog, form in the atmosphere. VOCs are released by sources ranging from trees and wildfires to vehicle exhaust pipes and consumer products such as cologne and perfume. As they undergo atmospheric oxidation, they can transform into a wide range of other compounds. Anyone in Southern California can attest to the urgency of this area of research — for example, in late July of this year, Los Angeles County was under an active ozone pollution advisory for almost a full week. While many people associate ozone with the protective ozone layer high in the stratosphere, ground-level or tropospheric ozone is a harmful secondary pollutant formed through atmospheric oxidation. Understanding how VOCs transform into pollutants like ozone is therefore critical to improving air-quality forecasts and informing strategies to reduce exposure. “My group is focused on trying accelerate our understanding of these networks of reactions so that we can do a better job of predicting how those pollutants form,” Barber said. “When we make decisions about how we might alter emissions, we can understand how that’s going to influence the production of these downstream pollutants.” With support from the W. M. Keck Foundation, Barber and Crabtree are developing new experimental approaches that will combine — and improve — techniques to study hundreds of chemical systems more efficiently than traditional methods allow. Instead of spending years decoding a single VOC, the project seeks to dramatically expand the pace and scale of discovery. The grant comes at a particularly important moment for environmental research. Barber, who joined UCLA in 2023, says funding for climate and air-quality research, especially for early career scientists, has become increasingly difficult to secure, a challenge compounded for ambitious projects that require building entirely new research infrastructure. The Keck Foundation’s support, Barber said, provides the flexibility to pursue bold early-stage, high-risk ideas that may be more difficult to fund using conventional federal funding sources. “It’s really, really hard to do environmental research under the current federal paradigm,” Barber said. “By stepping in and providing stable and flexible funding to explore this new idea, the Keck Foundation is making a huge difference to my research program.” In addition to funding early-career faculty, the Keck Foundation’s support is also focused on empowering graduate students like Crabtree in their scientific growth. The project gives Crabtree the opportunity to help develop an entirely new experimental approach to studying atmospheric chemistry — an experience that will provide him with valuable technical skills, scientific training and preparation for the next stage of his career. Stable funding also allows doctoral students like Crabtree to devote themselves more fully to research rather than balancing their scientific work with additional teaching responsibilities needed to cover funding gaps. “Getting to devote more of my time to research this past school year has greatly improved the pace and quality of our experiments, data analysis and planning for our future work,” said Crabtree, who is pursuing a Ph.D. in chemistry. “I feel very lucky — especially amid the current uncertainty surrounding scientific funding — to be able to continue exploring exciting knowledge gaps in our field and growing as a scientific researcher.” For Barber, mentorship is among the most rewarding and important aspects of her role as a faculty member. “Our jobs as faculty are to do good science and make good scientists,” she said. “I believe the Keck Foundation shares this belief and sees the potential positive impact this project can have.”
Race cars, politics, and sports: ‘Freedom 250’ roars through DC
At Washington Freedom 250 events, like this weekend’s IndyCar race at the National Mall, fans ask how politics might be impacting their sports.
The government is digging into who’s really doing work under small-business contracts
They're looking for, what is the lived reality on the ground, not what the corporate structure might otherwise suggest," said William Hart.
I’m 27 Years Old With a Business Managing $500 Million in Deals. My Clients Might Already Be on Your Phone.
Evelin Herrera's meetings with high net worth individuals inspired her firm.
Scientists finally know why astronauts struggle to poop in space — and reveal a hidden risk of long-haul spaceflight
A new NASA-backed study has pinpointed why astronauts often experience constipation in space and how that might affect their health on long-haul missions to Mars and beyond.
John Mayer explains why algorithms can't replace great radio
Give John Mayer 12 minutes and you might find yourself hooked. A mere 720 seconds to experience “Life with John Mayer,” his distinctive SiriusXM channel heading toward its third anniversary.
49ers injury updates: Robert Jones might miss the preseason finale
Kyle Shanahan believes Austen Pleasants avoided an ACL injury
After 25 years
The kid in a sweet shop, or not being able to sleep on Christmas Eve, is genuinely how gnarly old me feels about the Sky Blues being back in the Premier League after 25 long years away! The landscape, particularly financially, has changed enormously in the intervening quarter of a century, which is why it's refreshing – and slightly surprising – to see the owner Doug King sanction spending of – by all accounts – more than £120m of their £200m-plus windfall on enhancing last season's Championship-winning squad. Frank Lampard was vibrant and positive at his pre-match media conference, while at the same time acknowledging that their front foot, attacking philosophy, which yielded 95 points and 97 goals last season, might have to be tempered, particularly at places like Arsenal.
Yankees' Forgotten Pitcher Might Be Done in Pinstripes
This forgotten New York Yankees pitcher may have played his last game in pinstripes.
Raton City Commission Double Up Meetings
By Marty Mayfield KRTN Multi-Media Raton City Commissioners started the first of their two special meetings Thursday afternoon with discussion on possible zoning and ordinance changes after receiving overwhelming public comment against a potential data center that might want to locate in Raton. While other communities have created moratoriums against…
University Of Kentucky Using Horses To Get College Students Interested In Science, Research
“These animals are already woven into Kentucky’s identity and might also be the ones that draw its next scientists, researchers and Extension professionals.”
The Deep Dive: Sun vs. Shade — The Surprising Science of Summer Workouts
When the mid-summer heat sets in, taking your run or walk outdoors can feel like stepping into a furnace. To escape the heat, you might find yourself weaving from one side of the street to the other, wanting to be in the shade at all times.
One concern about fantasy managers drafting Chase Brown
The fantasy market believes Chase Brown is a locked-in, top-10 RB. That might be the case. But there is one big reason to steer clear.
The $1 million sports card club: LeBron James leads, Macklin Celebrini enters before legends
Some of the 33 names in the club might be a surprise, but the all-time greats still waiting for a seven-figure sale could be a bigger shock.
Xavier Becerra gets to play it safe in the race for governor, and he isn't making promises
The Democratic frontrunner is exceedingly cautious, preferring to study policy and avoid making promises he might not be able to keep
The traditional respiratory virus season hasn’t started, but Covid is already climbing
Are you coughing, hacking or feeling feverish? It may not be just a summer cold; you might want to consider taking a Covid test.
US might look to Swiss for affordable universal health care
A local congressional candidate proposes a Swiss-inspired health care model to lower costs and improve access.
The Sun’s Magnetic Field is Behaving Oddly. Astronomers Still Don’t Know Why.
Scientists say our star might be in a midlife crisis of sorts. What does that mean for life?
Apple’s Camera-Equipped AI AirPods Remain on Track for 2027 Despite Video Leak
An Apple Inc. effort to sell camera-equipped AirPods remains on track for 2027, despite a leak from the company indicating that the product might arrive sooner.
Does giving a camera wings dodge the FCC’s drone ban?
The HoverAir Versa found a loophole in the FCC’s drone ban. But it might not stick.
Why Don't Insects Live in the Ocean? Scientists Just Ruled Out One Possible Explanation Thanks to Deep-Diving Fly Larvae
Researchers thought that insects might not live there because their respiratory systems would implode from water pressure. But certain fly larvae in East Africa make daily trips toward the bottom of Lake Malawi with the help of strong air sacs that contain a stretchy protein
Watch Valve set up the Steam Frame in its own leaked videos
The Steam Frame launch might be around the corner.
The week in politics (Aug. 19, 2026)
On Wednesday's show: We discuss the latest developments in politics in our weekly roundup. And we contemplate what Houston might've been like if Texas had been allowed to split into five separate states.
5 smartwatches you should buy instead of the Google Pixel Watch 5
The Pixel Watch 5 is Google's latest smartwatch, but it might not be the best choice for everyone. Here are five alternatives worth a look.
Why These Three Games are Important for Orlando Magic
The Orlando Magic have a lot of significant games on their 2026-27 schedule, and these three might be the most important.
Wake Up, It Looks Like Terranigma Might Finally Be Getting A Re-Release
"All the living things in this world await your awakening"
Smithsonian Brings Sandy Beach Scientists to Texas A&M Galveston
Scientists from the U.S. and South America are workshopping at Texas A&M University at Galveston (TAMUG) this week to expand sandy beach research and broaden collegiate learning opportunities.The Tides of Opportunity Project, co-led by the Smithsonian’s Marine Global Earth Observatory (MarineGEO) Program, TAMUG, the Smithsonian Marine Station, the Smithsonian National Zoo and Conservation Biology Institute, and the University of Miami, is a collaborative monitoring project with marine science professors and their students.Tuesday, Aug. 18, through Friday, Aug. 21, 15 professors and marine science professionals from the United States, Brazil, Peru, and Urugay will co-design a sandy beaches monitoring protocol and associated course modules and test the protocol in the field.The goal is to incorporate sandy beach monitoring protocols into marine science courses, which college faculty and students can use to achieve learning goals while providing essential data can help researchers diagnose the health of an understudied critical coastal habitat.Dr. Guilherme Corte, an assistant professor of marine biology in the College of Marine Sciences and Maritime Studies at TAMUG, is a principal investigator for MarineGEO. Texas A&M University at Galveston students and faculty package samples collected on the beach to take to campus for study in the Benthic Ecology Lab. Credit: TAMUG Division of Marketing and Communications“One third of the world’s ice-free coastlines are made of sandy beaches, and they go from pole to pole,” Corte said.However, despite their abundance and place as one of the most accessible coastal ecosystems for college-level education and research, they remain critically understudied.The Tides of Opportunity Project recognized that accessibility makes sandy beaches uniquely suited for engaging professors and students, including those with limited resources.“Any students can do sandy beach research,” Corte said, encouraging instructors to help students take a break from typing questions into artificial intelligence tools and embrace opportunities to do real science. “Providing this hands-on experience is something unique.”Tides of Opportunity Project goals include:Training a cohort of professors from across the Americas in standardized sandy beach monitoring methods; Equipping participating faculty with classroom modules, field tools, and multilingual teaching materials; Expanding MarineGEO with new monitoring sites focused on the implementation of long-term sandy beach monitoring; Strengthening hands-on, college-level learning experiences; And cultivating interest, learning, and efficacy in science among college-level students.By the end of this week, workshop participants plan to have a final version of the protocol and associated course modules that we can share with professors shortly after the workshop ends to then test with their students in courses that take place between September 2026 and February 2027.The scheduleDay 1: Tuesday, Aug. 18Location: Aggie Special Events Center (ASEC), Rooms 102 B and C, Texas A&M University at Galveston 8:30 – 9 a.m. Breakfast9 – 9:30 am Welcome and brief group introductions9:30 – 10 a.m. Introduction to Tides of Opportunity Project, Design Workshop, MarineGEO, and the Connecting Coastlines to Campuses Program (presentation)10 a.m. – 1 p.m. Introduction to workshop participants and project coordination team (presentations by each participant)• Brief lunch break from 12-12:30 p.m.1 – 3 p.m. Discussion about why collaborative science matters (presentation and interactive group discussion)3 – 4:15 p.m. Introduction to sandy beaches (presentation and group discussion)Day 2: Wednesday, Aug.19Location:• Morning sessions: ASEC Rooms 102 B and C, Texas A&M University at Galveston • Afternoon sessions: Corte’s field site (location available upon request)8:30 – 9 a.m. Breakfast9 a.m. – noon Prep for fieldwork (presentation and interactive group discussion)• Finish conversation about importance of studying sandy beaches• Go through sandy beaches monitoring protocol and field sheetsNoon – 12:45 p.m. Lunch12:45 – 1:30 p.m Prep for field (including driving to the field site)1:30 – 5:30 p.m. Fieldwork & bring samples back to TAMUGDay 3: Thursday, Aug. 20Location:• Breakfast: ASEC Rooms 102 B and C, Texas A&M University at Galveston • Fieldwork: Guilherme’s field site (location available upon request)• Lab/afternoon sessions: TAMUG lab (location available upon request) and ASEC Rooms 102 B and C8:30 – 9 a.m . Breakfast9 – 11 a.m. Return to field• Shorter field trip – recovering samples left out overnight11 a.m. – noon Lab work12 – 12:45 p.m. Lunch12:45 – 2:45 p.m. Continue lab work3 – 5 p.m. Discuss with professors the feasibility of implementing protocol in their courses and where might need to make changes (discussion)Day 4: Friday, Aug. 21Location: ASEC Rooms 102 B and C, Texas A&M University at Galveston 8:30 – 9 a.m. Breakfast9 a.m. – noon Group Discussion• How to evaluate student learning and engagement• Course modules• Next steps
Why Apple's camera-equipped AirPods may not be the 'pervert pods' consumers fear
Apple’s leaked camera-equipped AirPods might avoid the privacy pitfalls of other AI wearables by preventing users from recording photos and videos.
James Fishback Is Probably About to Lose. His Politics Might Be Winning.
He’ll likely lose the Republican gubernatorial primary in Florida. But is he winning a larger war?
Cam Neely Makes Surprising Admission About Bruins Captain Decision
David Pastrnak and Charlie McAvoy appear to be obvious candidates,, but Cam Neely revealed why the Bruins might leave their captaincy vacant again.
Why Should We Keep Trying to Talk Across Political Differences?
john a. powell makes the case for trying to bridge our differences even when it’s hard, while acknowledging when we might step away.
A popular sleeping pill stuns scientists with unexpected Alzheimer’s breakthrough - Futura-Sciences
An Unlikely Ally Hidden in the Medicine Cabinet Alzheimer’s disease, the bane of an aging brain, might just have found itself an unexpected friend right in our own pharmacies. Researchers from Washington University in St. Louis have shed new light on the connection between sleep and brain health. They found...
Waist Size Is Accurate Way To Gauge Unhealthy Excess Weight, Study Says
By Dennis Thompson HealthDay ReporterTUESDAY, Aug. 18, 2026 (HealthDay News) — Are you worried that extra pounds might be harming your health? Check the notches on your belt, a new study suggests. Waist size might be one of the simplest and most effective measures to detect health risks associated ...
Our Survival Might One Day Rely on Nuking a 'City Killer' Asteroid. Scientists Just Tested Whether It'll Work
Things got weird.
Our Survival Might One Day Rely on Nuking a 'City Killer' Asteroid. Scientists Just Tested Whether It'll Work
Things got weird.
Focusing on healthy aging might encourage older adults to get vaccinated
A French study finds that heart or cognitive health benefits might be the biggest motivators.
Vikings Get Telling Insider Outlook on J.J. McCarthy, Carson Wentz
The Minnesota Vikings have their starting QB in Kyler Murray, but their QB2 situation might be up for grabs in these final two preseason games. For now, QB2 is J.J. McCarthy after losing the QB battle to Murray, but now he might need to fend off veteran Carson Wentz for the backup job.During McCarthy’s time […] The post Vikings Get Telling Insider Outlook on J.J. McCarthy, Carson Wentz appeared first on HEAVY.
Australia needs more people who think like scientists—here's what that means
How we think and feel about science develops from an early age—and we never know where that early interest might take us.
Nashville's statement, Houston's surge & more from Matchday 20
By Charles BoehmThe days are growing shorter, and the kids are going back to school. The FIFA World Cup is in the rearview mirror, and so is Phase One of Leagues Cup.You might not have heard a starter...
J.J. McCarthy Gets Concerning Take Before Vikings-Ravens Preseason Game
The Minnesota Vikings have already determined their starting QB to be Kyler Murray. After making that decision, it appeared that J.J. McCarthy would be QB2; however, that might not be set in stone with two preseason games left. Minnesota will host the Baltimore Ravens on Aug. 22 at U.S. Bank Stadium, and Judd Zulgad of […] The post J.J. McCarthy Gets Concerning Take Before Vikings-Ravens Preseason Game appeared first on HEAVY.
St. Louis Cardinals vs Cincinnati Reds Series Preview
The St. Louis Cardinals begin a brutal week where they’ll play 5 games in 4 days against the Cincinnati Reds beginning with a day/night doubleheader on Monday. What we know about pitching matchups already shows this might be one of the most interesting and possibly pivotal weeks of the season so far. Here are the […]
Why Are Tech Companies Buying Creator Businesses?
OpenAI and HubSpot are spending millions on creator businesses. What are they really buying and why might an audience be worth more than the actual media company itself?
The Scientists Who Want to Steer Hurricanes
Over the weekend, Hawaii was lashed by Hurricane Lala, which has washed away homes, left more than 125,000 people without power, shut down two of the state’s busiest airports, threatened dangerous flash flooding and, at time of writing, has killed one person. What if we could’ve steered the storm away from Hawaii, into the vast expanse of the empty Pacific Ocean that lies all around the islands—where no one could get hurt? This scenario might sound like the stuff of science fiction. But earlier this year, a peer-reviewed study published by the Public Library of Science found that it might be possible, and sooner than we think. The study was titled: “Weather Jiu-Jitsu: Prospects for atmospheric nudging to defuse the impact of catastrophic weather extremes.” According to the paper, the controversial practice of cloud seeding could enable human beings to make hurricanes change direction. The potential results could be astounding: The authors suggested that Hurricane Sandy, which in New York City alone killed 44 people and caused $19 billion of damage in 2012, could’ve been diverted by 200 miles, missing the metropolis entirely. Cloud seeding, which first succeeded in the U.S. in 1946, is a practice whereby small particles—for example, dry ice, silver iodide, or salt—are dropped into clouds, causing moisture to condense into precipitation. In the 1960s, the U.S. government launched Project Stormfury, an experiment that saw Navy pilots flying into the heart of a hurricane, dodging winds over a hundred miles per hour, to cloud-seed inside it, in the hope of reducing the storm’s power. “The seeding,” the theory went, “would stimulate the formation of a new eyewall that would surround the existing eyewall. The new eyewall would contract, strangling the old eyewall and reducing the intensity of the hurricane.”
Dante Miller injury: ‘Might be a situation’ with Giants’ RB
Missing time could end ‘Turbo’s’ chance of making the 53-man roster.
Gen Z is eyeing up ‘secure’ healthcare jobs to AI-proof their careers, but be warned: Chiropractors, doctors and paramedics are the unhappiest workers
Health care workers report burnout and lower job satisfaction. So Gen Z's safest bet might just be behind a counter, not a stethoscope, research suggests.
Why Scientists Fear This Everyday Food Could Soon Be Poisoning Millions - Futura-Sciences
Why Might Rice Become Dangerous? The hotter it gets and the more carbon dioxide (CO2) there is in the air, the more rice absorbs inorganic arsenic, according to a new study. In short, as the climate heats up and CO2 concentrations increase, rice becomes more toxic—and could even cause deadly...
Big Pivots: Ambition, affordability and the nexus of climate change politics
In Crested Butte, Republican voter registration barely breaks 5%. Given this political makeup, Crested Butte might seem like a strange venue for dissecting American polarization over climate change. The national pace of climate action, however,...
Elandon Roberts Reveals What Drove Him to Return to Steelers
UNITY TWP, Pa. — Elandon Roberts might tell you to appreciate your surroundings more. Having re-joined the Pittsburgh Steelers on […] The post Elandon Roberts Reveals What Drove Him to Return to Steelers appeared first on Steelers Now.
Seahawks corner Devon Witherspoon signs. Will Christian Gonzalez be next?
Per reports, Devon Witherspoon agreed to a deal that makes him the NFL's highest paid corner. Might that set the stage for Christian Gonzalez?
Pixel 11 ads show a mysterious screen-equipped tracker that’s not Pixel Watch 5 or Fitbit Air [Gallery]
Google might have another fitness tracker in the works, as a pair of new ads online show off a mysterious...
Buccaneers' undrafted rookie QB Jalon Daniels impresses in preseason debut
Buccaneers undrafted rookie quarterback Jalon Daniels is fourth on the depth chart, but he looked in his preseason debut like he might have an NFL future.
Reagan’s PATCO Showdown ignited Colorado labor backlash
Forty-five years ago this week: “It’s the old Nixon reaction as far as I’m concerned. He thinks he’s the Great God Almighty and can do no wrong … in the eyes of the public,” said Zelda Bransted, spokesman of the Colorado AFL-CIO. “I sincerely hope it backfires.” Bransted made the comment in response to President […]
Montenegro Wants To Be Europe’s Next Crypto Hub, But Weak Regulation Might Be Costing It Big Business
Montenegro’s crypto market is growing despite regulatory gaps that could deter investors and leave billions in digital-asset transactions beyond effective oversight.
Shavon Revel Jr. Made Bold Claim After Cowboys-Rams Practice
The Dallas Cowboys and Los Angeles Rams had a joint practice that gave the teams a chance to face different competition for the first time.That might have exposed something within the Cowboys that might become public knowledge. First, George Pickens and CeeDee Lamb are as good as many believe.One other thing, though, is how good […] The post Shavon Revel Jr. Made Bold Claim After Cowboys-Rams Practice appeared first on HEAVY.
The Science Behind Why a Banana at Night Might Help You Sleep
Eating a banana may help you relax and improve your sleep hormones thanks to nutrients like tryptophan, vitamin B6, magnesium, and potassium.
Trump Team’s Use of Arcane Budget Rule Threatens Medicaid Coverage
Coverage for hundreds of thousands of Arkansas Medicaid enrollees next year is in question after the Trump administration refused to renew a key state waiver. The state might not be the last to have to adjust to an arcane rule change under the One Big Beautiful Bill Act.
Cowboys players who might be losing their roster battles
Which Cowboys players do you think need to turn things around right now?
Google's new Pixel 11 chip might not be 2nm, after all
Rumors seemed almost certain that the Tensor G6 would be a 2nm chip, but a new interview claims Google went with 3nm again.
There Is No Reason Not To Play South Of Midnight Anymore
With Compulsion Games now newly independent, their BAFTA-winning game is now free from Xbox and anything else that might have kept you from trying it
The mindblowing invertebrates you have never heard of
Each year the Guardian runs a competition to find the invertebrate of the year. To find out more about the 2026 nominees science editor Ian Sample hears from climate reporter Petra Stock, environment reporter Oliver Milman and Science Weekly co-host Madeleine Finlay. They each nominate an incredible invertebrate that you might never have heard of, and argue why their choice should come top. Vote for your favourite now and the winner will be unveiled on 17 August
AI needs science’s search history
“Actually, that’s where the gold is,” said Alasdair Russell, my graduate school friend who leads a pre-clinical genome editing group at Cambridge. He was talking about the winding road of science that is omitted from published papers. “When you’re discussing how to do the experiment, and why this way is better than another way, and what does the data really mean? I know what it shows, but what does it mean?” At RAAIS 2026, he described how his group has begun logging the twisting path of discovery as it happens, recording the verbal and written exchanges that normally disappear. Ideas become nodes in a living graph: they branch when a meeting produces two plausible experiments, merge when separate lines of evidence converge, and go dark when someone quietly stops pursuing them. In his implementation, one agent scores novelty, while another tries to learn “how scientists think and how they navigate through a complex world of data,” so that high-potential nodes can trigger deeper investigation. As frontier AI labs deploy agents toward scientific discovery, giving AI authentic scientific taste remains a trillion-dollar dilemma. The bottleneck is that the record we have kept for centuries of science might be insufficient to get us there. The experiments that never make the paper Peter Medawar, 1960 Nobel laureate and “father of transplantation,” asked in 1963 whether the scientific paper was a fraud, and answered yes: the form of the paper misrepresents the thinking that produced it. Sixty years on, the diagnosis is unchanged. A paper presents a clean progression from hypothesis to result to conclusion. Lost along the way are the unconventional theories, the abandoned or unaffordable methods, and the underwhelming and inconclusive data. It reads like a browser history with every dead end deleted: the ten open tabs, the four rephrased queries, the wrong turn down a subforum. All scrubbed, leaving one clean path from question to answer as the canonical path. What has changed since then is that the discarded material is now worth something. No high-impact journal wants these artifacts, but raw trial and error is the most likely source of the training data required to develop scientific intuition, or what researchers call taste. Earlier attempts to capture the discards were motivated by scientific integrity. The Journal of Negative Results in Biomedicine launched in 2002 to publish rigorous studies that disputed established models or exposed ineffective treatments. Its archive preserved negative conclusions after they had become papers, rather than the live alternatives and arguments that produced them. BioMed Central closed it in 2017, saying the mission had been served now that other journals publish null results. A less generous reading is that in fifteen years it published around 200 papers because almost nobody wants to read a negative result, let alone write one up when it will not count toward academic tenure. AI models are different. Even an uninteresting negative result can be useful, provided it is labeled. Earlier this year, Anthropic put a version of this to the test. The company pulled 129 decision points from real Claude Code sessions between January and March 2026, showed models the work up to a human detour, and asked what should happen next. Claude Mythos Preview beat the human choice 64% of the time, while Opus 4.5 managed 51%. The comparison was tilted toward the models because Anthropic deliberately chose moments where the human decision had room for improvement. On 127 further scenarios where the human action was already strong, the models improved on it only about 20% of the time. The study was possible because Anthropic’s researchers work inside a tool that logs by default. The reasoning, detours and outcome are produced in the same working environment. Biology has no equivalent. Its reasoning happens in hallways, at benches, in Slack threads and on whiteboards, while the outcome arrives weeks later somewhere else. The record has to emerge from the work itself. Ask scientists to reconstruct it afterwards and we’ll create another polished account. Subscribe A log is not a label Before any of this becomes training data, a negative result has to say what failed. The first paper published in the Journal of Negative Results in Biomedicine examined 234 negative studies across five leading medical journals. Only 30% discussed statistical power, and half clearly defined a primary outcome. Tell a model an experiment failed, without telling it whether the assay was underpowered, a reagent had degraded, or the hypothesis was simply wrong, and it will learn noise with confidence. Decision histories have a second missing label too. When a lab considers five experiments and runs one, only the chosen branch returns an outcome. The other four are experimental counterfactuals. Researchers call this the selective labels problem: the data reveal results only for the actions someone chose to take. Such a record can teach a model to imitate a lab’s taste, but it cannot establish that the taste was good. It also smuggles local constraints into general lessons. A lab that never ran cryo-EM because it did not own a microscope teaches a model that cryo-EM is rarely the right call. Alasdair’s nodes preserve the candidate set, which is the necessary first step. To be useful, each decision record needs six fields: The evidence available at that moment, and nothing that arrived later. The candidates considered, including the ones dismissed in a sentence. For each candidate: the expected result, the confidence attached to it, and the cost in time and money. The route chosen, and the reason. What happened next. How the evidence changed the scientist’s view. These must be timestamped before the outcome, because hindsight turns uncertainty into inevitability. Disagreement also has to survive. Averaging three scientists into one clean rationale reproduces exactly the information loss we are trying to fix. But there is an obvious failure mode here. Once decisions are logged and scored, people log for the record post-facto. Anyone who has watched an electronic lab notebook fill up with retrospective tidying knows how quickly a research tool becomes a compliance exercise. A record that costs a scientist ten minutes of honest reflection per decision is worth far more than one that costs an hour of performance. A publication initiative called Registered Reports offers a useful starting point. Here, researchers submit their rationale, methods and analysis plan for peer review before the data exist, and the journal commits in principle to publish if they follow the approved plan. Nature has now expanded the format across every field it covers. This approach to paper writing timestamps intent before the outcome, but it freezes one plan. A useful search history must also preserve how the plan changed, which alternatives were rejected, when, and on what evidence. Subscribe Run the runner-up Autonomous labs show what happens when decisions and outcomes are connected in a loop. Liverpool’s mobile robotic chemist ran 688 experiments over eight days in a ten-variable formulation space. A batched Bayesian search used each result to choose the next experiments and found photocatalyst mixtures six times more active than the starting formulations. Every completed experiment changed what the system did next. The robot optimized within a goal and search space that humans had already chosen. It did not decide which scientific question mattered. So what this work demonstrates is narrower, but still useful: a search history pays off when the options return standardized outcomes quickly. Open-ended biology is harder because branches can take weeks and the discarded alternatives may never be run. Some exploration therefore has to be bought. Where two branches are plausible and the stakes justify the cost, a lab should sometimes run the runner-up. Otherwise the record captures what today’s scientists usually chose and stays silent on what they systematically overlooked. A funder could ring-fence a small fraction of a grant for the branch not taken, provided that the decision record and the outcome are both deposited. That costs money, but so does having every lab rediscover the same abandoned path. Test whether taste transfers When it comes time to evaluate if our new AI system exhibits taste, the comparison should run across laboratories and fields. At selected decision points in a live research campaign, we should freeze the six fields: the evidence, the candidates, expected results, confidence, costs and the choice made. Experts then rank the options before the outcomes are known, and those outcomes are checked independently later. We could give models one of two diets - papers alone, or papers plus decision histories - and ask them to rank the next experiment on unfamiliar projects. Then, we score information gained per dollar and week, calibration, and how quickly weak branches are abandoned. If histories improve choices only inside the lab that produced them, they amount to useful organizational memory. If they improve choices on unfamiliar problems elsewhere, Alasdair’s group will have captured something science has never managed to write down: a transferable record of taste. Until that happens, a scientific search history is a promising record, not yet a training set.
iPhone 18 Pro and iPhone Ultra: When is the Next Apple Event?
It is now mid-August, meaning that Apple's annual iPhone event is just around the corner. Below, we take a look at when the event might be held this year. This September, Apple is expected to unveil the iPhone 18 Pro, iPhone 18 Pro Max, and an all-new foldable iPhone that will reportedly be named the iPhone Ultra. The regular iPhone 18, a lower-end iPhone 18e, and the iPhone Air 2 are not expected to be announced until around March 2027, as part of a new launch strategy.
The drug lenacapavir is a mighty weapon against HIV. Its rollout gets mixed reviews
It's a twice-a-year injection that is remarkably effective in preventing an HIV infection. Distribution is starting. But questions are being raised about getting it to the areas that need it most.
A fantastic hyperlocal restaurant hides on this Calif. college campus
It might be one of California's most special farm-to-table experiences.
Why Karoline Leavitt might be impossible for Trump to replace
Donald Trump hardly needs anyone else to serve as his mouthpiece.
A Surprise Credit After an Overseas Purchase: the Tariff Refunds Now Flowing Through Shippers
NEW YORK (AP) — If you bought something from an overseas vendor last year, it might be time to check your bank account. Shippers including FedEx and UPS that acted as customs brokers for imported packages and received tariff refunds from the U.S. government have started to pass on those refunds to ...
49ers insider shares growing concern over key position battle
The 49ers might have a tough decision to make at left guard between two underwhelming players.
5 TV Shows To Watch If You Like Sheriff Country
If you're already hooked on Sheriff Country after just one season, here are five other shows that might scratch your crime drama itch.
Panthers Might Be Without WR Xavier Legette For Preseason Opener
Carolina Panthers wide receiver Xavier Legette might not be playing in Saturday’s preseason game at the Buffalo Bills after suffering a stinger early in training camp.
iPhone Ultra’s cameras might get very unorthodox placement, per leak
iPhone Ultra will be unveiled next month, and a new leak indicates the device’s front cameras could be positioned in unusual spots.
Small Business Spotlight: Specialty dental practice takes root on Market St.
WHAT MADE YOU WANT TO OPEN BLUE HERON ROOT CANAL SPECIALISTS? OWNER SARAH ERMOSHKIN: “I’ve always been an entrepreneur at heart. When I was 23 years old, I owned a cafe in Seattle, where I even fought to oppose oppressive sales taxes on espresso drinks. After selling that business, I got married and started a family. Once my children were in school, I attended dental school through the Navy Health Professions Scholarship Program (HPSP), which covered my tuition and provided a stipend. From the beginning, my goal was to eventually own my own practice after completing my military service. The work I do is incredibly rewarding and being able to create an environment that puts patients first while helping employees grow professionally makes every day as a business owner meaningful.” WHAT DOES YOUR BUSINESS PROVIDE? ERMOSHKIN: “Endodontists are often called ‘pain doctors’ because our primary mission is to relieve pain and save natural teeth. We specialize in root canal therapy, retreatment of nonhealing root canals, treatment of root resorption, apicoectomies – microsurgical root-end procedures – and vital pulp therapy for children. Our goal is to preserve teeth that might otherwise need to be extracted and replaced with implants. Saving a patient’s natural tooth is almost always the best long-term solution for their oral health.” HOW DOES YOUR MILITARY TRAINING HELP YOUR BUSINESS? ERMOSHKIN: “My military service taught me how to lead, collaborate and make decisions under pressure. I worked closely with senior leadership while treating a large patient population and collaborating with specialists across multiple disciplines. During the COVID-19 pandemic, (I) served a dual role as Navy dentist and as the public affairs officer for Naval Health Clinic Annapolis, where I helped develop medical and dental communications for the midshipmen and support staff, while coordinating with the broader Navy Capital Region. We worked closely with other military treatment facilities to share best practices and deliver consistent public health messaging. Those leadership experiences continue to shape how I lead my team and serve our patients today.” WHAT CHALLENGES ARE YOU FACING RIGHT NOW IN YOUR BUSINESS? ERMOSHKIN: “One of our biggest challenges is overcoming the misinformation surrounding root canal treatment. Root canals are safe, effective and often the best way to relieve pain while preserving a natural tooth. Unfortunately, many people choose extraction because they believe it’s less expensive or because they’ve seen misleading information online. What they may not realize is that losing a tooth can lead to shifting teeth, changes in the way they bite and chew and significantly higher costs to restore their smile later.”
Yankees' Upcoming Pitching Decision Might Surprise You
The New York Yankees have a big pitching decision to make, and their strategy may surprise you.
How to watch the Made by Google event stream and Pixel 11 announcement
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Khvicha Kvaratskhelia is back for PSG in the UEFA Super Cup: Georgian missed the World Cup but might just be Europe's best
Ahead of the UEFA Super Cup between Paris Saint-Germain and Aston Villa, Adam Bate reports from Salzburg on why this is a chance for Khvicha Kvaratskhelia to remind everyone that this World Cup absentee was the outstanding player in European football last season...
The Hollywood Merger Won’t Kill Entertainment Jobs. Blocking It Might
Something besides industry consolidation is clearly to blame for Hollywood’s current contraction.
Even Trump Voters Might Not Be Able to Resist Voting for This Candidate Instead
I’ve never had any use for U.K. political tradition. Until now.
It’s Kyler Murray’s Team Now, for Better or Worse
The Vikings have finally announced the results of the team’s contentious quarterback competition, and according to ESPN’s Adam Schefter, Kyler Murray has been named the Week 1 starting quarterback for the 2026 season, putting an end to the much-talked-about position battle and handing the keys to the Vikings offense to the former Cardinals veteran. After an open battle to start camp got going, Murray put distance between himself and now-backup quarterback J.J. McCarthy over the past few weeks, and while there were some recent struggles that might have put into question Murray’s lead in the QB race, it ultimately didn’t matter to the Vikings brass, who felt they needed to make a decision before the Vikings’ preseason opener against the Giants this Saturday.
2026 Fall Preview: Willow Springs Volleyball
Share on Facebook Share on Twitter By Michael Cignoli (For OzarksSportsZone.com) When Dawn Gastineau’s volleyball career ended, she never considered the possibility that life might one day lead her back to the sidelines. But that’s exactly where
GTA 6 might not cost $100, but most of the people pre-ordering it are buying it at that price, Take-Two reveals
Rockstar put a lot of effort into enticing people into pre-ordering the more expensive Ultimate edition.
Trump loves data centers. Americans hate them
If there’s a true populist issue built for our time, it might be opposition to AI data centers. Lawmakers and candidates from both parties across states are increasingly positioning themselves as critics of data center proliferation. And recent primary results suggest it’s a pretty potent issue.
The Weeknd says he’s not changing his stage name as planned: ‘Imma be here forever with you’
The Weeknd has talked about changing his stage name for years. Now he might not change it at all.
Jeff Bezos might finally get his hands on a sports team
Jeff Bezos is reportedly close to buying his first stake in a sports team: the U.K.'s famed Liverpool Football Club.
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
Future Apple Watches Might Ditch the Screen
The company is reportedly exploring new form factors and, shockingly, round displays.
Scientists Release Biggest 2D Map of the Universe
Key Takeaways The DESI Legacy Imaging Surveys combined more than 263,000 telescope exposures to make the largest 2D map of the universe in visible and near-infrared light. Astronomers can pair the Legacy Surveys map with their own observations to explore our universe and search for rare phenomena. The 2D map serves as the foundation for the Dark Energy Spectroscopic Instrument survey to measure the universe in 3D and investigate dark energy. Hold on to your telescopes: the DESI Legacy Imaging Surveys team has released the largest-ever 2D color map of the universe. The 5.6-trillion-pixel map contains nearly 4 billion celestial objects, primarily stars and galaxies. The data is available for all to use and publicly viewable through the Legacy Survey Sky Viewer. Astronomers and citizen scientists can explore the map or combine it with their own observations to better understand our universe. Researchers can search for rare phenomena like gravitational lenses, observe fleeting events like supernovae, and investigate two of physics’ biggest mysteries: dark matter, the invisible substance that accounts for most of the mass in our universe, and dark energy, the force driving our universe’s accelerating expansion. The new map builds on earlier versions from the DESI Legacy Imaging Surveys that have already proved invaluable. To date, more than 1,800 science papers that reference the Legacy Surveys data have been published. “It’s part of the fabric of astronomy research now,” said David Schlegel, a co-lead of the Legacy Surveys and scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). “When you’re working with astronomical objects today, you often start by pulling up the Legacy Imaging Viewer to see what you’re looking at.” Covering roughly 75% of the sky in visible and near-infrared light, the updated map provides a deep view of the extragalactic universe not blocked by the dust and stars of our own Milky Way. Researchers expect it will remain the most comprehensive 2D map of our universe for years to come. More than 160 scientists contributed to data collection for the project, and a team of 20 produced the final dataset released today. It was built by combining 263,407 telescope exposures from three ground-based sky surveys: the Dark Energy Camera Legacy Survey (DECaLS) at NSF Cerro Tololo Inter-American Observatory, the Mayall z-band Legacy Survey (MzLS) at NSF Kitt Peak National Observatory, and the Beijing-Arizona Sky Survey (BASS) at the University of Arizona’s Steward Observatory. That was supplemented by years of data from NASA’s Wide-field Infrared Survey Explorer (WISE) satellite mission and additional public data. “For our team, these data are fundamental to our investigation of the expansion history of the universe and the formation of our galaxy,” said Arjun Dey, co-lead of the Legacy Surveys and an astronomer at NSF NOIRLab. “But the skies belong to everyone, and this survey gives everyone the chance to explore the sky and marvel at its wonders.” Here be galaxies The DESI Legacy Imaging Surveys were originally conducted to prepare for the Dark Energy Spectroscopic Instrument (DESI) survey. The Legacy Surveys’ 2D map is essentially a deep photograph of the sky; it records where galaxies and stars appear and how bright they appear. This crucial step enables DESI to select objects and measure their light in different wavelengths to determine their distances, building the largest high-resolution 3D map ever made. Scientists study the way galaxies have clustered at different ages of the universe to track dark energy over time. In April 2026, DESI completed its original five-year survey ahead of schedule and with vastly more objects than expected. The early results have shown surprising hints that dark energy’s impact may be weakening over time — a paradigm shift that could potentially shape the predicted fate of our universe. DESI expects to publish improved results using their first five years of data in 2027 and is continuing observations into 2028. DESI was so efficient at observing galaxies, the Legacy Surveys map needed to expand. Early on, “it became clear we might run out of galaxies to look at and run out of sky, and we better start doing something about that,” said Schlegel, who also works on DESI. The new Legacy Surveys map has been used to select DESI targets since June 2026 and will guide the telescope’s operations over the coming years. Computing the cosmos Merging hundreds of thousands of images taken on 2,285 nights, each with unique atmospheric and telescope conditions, was a massive computational effort. It took about a year to develop the computer code and eight weeks to process all the images at the Perlmutter supercomputer at the National Energy Research Scientific Computing Center (NERSC) at Berkeley Lab. Beyond supporting DESI, the Legacy Surveys will be a foundational reference for the next generation of telescopes. As new observatories like the NSF-DOE Vera C. Rubin Observatory (jointly funded by NSF and DOE’s Office of Science) and NASA’s Nancy Grace Roman Space Telescope come online, researchers can compare their observations with one of the deepest and most comprehensive views of the sky ever assembled. The Legacy Surveys data will also help scientists train artificial intelligence tools to analyze petabytes of astronomical data and accelerate new discoveries. It will be among the datasets used in an astrophysics pilot project within the American Science Cloud, part of the DOE’s Genesis Mission. The DESI Legacy Imaging Surveys are supported by the U.S. Department of Energy’s Office of High Energy Physics; the National Energy Research Scientific Computing Center, a DOE Office of Science user facility; the U.S. National Science Foundation, Division of Astronomical Sciences; and the partner institutions. DESI is supported by the DOE Office of Science and NERSC. Additional support for DESI is provided by the NSF; the Science and Technology Facilities Council of the United Kingdom; the Gordon and Betty Moore Foundation; the Heising-Simons Foundation; the French Alternative Energies and Atomic Energy Commission (CEA); the Secretariat of Science, Humanities, Technology and Innovation (SECIHTI) of Mexico; the Ministry of Science and Innovation of Spain; and by the DESI member institutions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
VIDEO: Kilauea Volcano Update, Lava Fountain Science
HAWAIʻI VOLCANOES NATIONAL PARK – Scientists examine how lava chemistry correlates with higher lava fountains, and they are wondering if Kīlauea might be in a growth phase.
How Does Your Samsung Galaxy Watch Measure Antioxidant Levels?
You might not know this, but your Samsung Galaxy smartwatch has a function to measure your antioxidant levels, which it does with special LEDs.
The Giants might be on the verge of adding another defensive back
J.T. Woods tried out last week, and visited the Giants on Sunday.
Our Opinion: Don’t delay studies of health, environmental impact of data centers
In so many ways, it was the opposite of just about everything one might expect from a public meeting these days. An overflow crowd of residents jammed into the Lackawanna County Commissioners’ meeting room in Scranton on Wednesday,…
Frequent cannabis users wake up with their “stress hormone” already elevated
Frequent cannabis users may wake up with unusually high levels of the stress hormone cortisol, suggesting their daily stress rhythms could be disrupted. Researchers say the finding raises questions about whether using cannabis for stress relief might, over time, interfere with the very system that helps the body handle stress.