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Infantino’s FIFA: Ten years of power, politics, and so-called ethics

Gianni Infantino promised reform, transparency, accountability, and a “new FIFA.” Ten years on, Infantino’s FIFA is instead defined by political proximity, weakened scrutiny, and an increasing alignment with state power at the highest levels.

Apr 12 • 8:00 PM EDT • Politics • playthegame.org

RFK Jr. Once Touted Raw Milk. Now He’s Stopped Talking About It.

The health secretary has instead promoted whole milk, a politically safer choice, as he seeks to avoid “weird stuff.”

Apr 11 • 7:00 PM EDT • Health • wsj.com

“AI polls” are fake polls

A few weeks after Donald Trump’s second presidential win, I took the train up from London (where I was living at the time) to Oxford to attend a conference on polls and forecasts of the 2024 election. Most of the attendees were pollsters or academics, but I also watched presentations from Aaru and Electric Twin, two companies that do what is interchangeably called synthetic sampling, silicon sampling, or synthetic audiences. Stripped of startup jargon, that means they use large language models (LLMs) to simulate responses to public opinion polls by having AI agents take on the role of survey respondents. I had already heard of Aaru thanks to some articles with eye-catching headlines like “No people, no problem: AI chatbots predict elections better than humans” in the months leading up to Election Day. The founders were making some big, some might even say far-fetched claims, such as: “within two years, we will simulate the entire globe — from the way crops are grown in Ukraine to how that impacts production of oil in Iraq, trade through the strait of Malacca, and elections for the mayor of Baltimore.” When Semafor asked Aaru’s cofounders — Cameron Fink and Ned Koh — about my boss, they said “we respect all those who came before us.” Nate (as he so often does) shared his thoughts on Twitter: Fink and Koh were relatively good-natured about this back-and-forth when we spoke at Oxford. They even offered to mail me one of the t-shirts featuring Nate’s quote they apparently had made. I never took them up on the offer, which I now somewhat regret. These synthetic sampling companies fell off my radar for a while, but they do still exist. In fact, Aaru recently received a $1 billion valuation. Is what they’re doing anywhere close to the most important frontier in AI development? Not by a longshot, especially when Anthropic just developed a model so adept at exploiting software vulnerabilities that it’s only being released to 40 companies. Still, silicon sampling is increasingly finding its way into public polling. Axios reported in March that “a majority of people trust their own doctors and nurses” based on findings from Aaru — without mentioning that the “people” in that sentence were actually LLMs. Around the same time, the Public Sentiment Institute “boosted” their online sample of 373 real survey respondents with 114 AI agents.1 (Spoiler alert: even the co-founder of Electric Twin doesn’t think that’s a particularly defensible approach.) Polling companies like Qualtrics and Ipsos are also developing synthetic data panels. So, what should we make of these … “polls”? Let’s get one thing out of the way: whatever they are, they’re not polls in the way that term is usually defined. Subscribe You can’t replace polls with AI On one hand, using LLMs to essentially make up fake survey respondents sort of sounds like the dumbest idea ever, one that will at best imperfectly replicate real polls while introducing all sorts of biases. On the other hand, with LLMs improving at a remarkable, perhaps even alarming rate, maybe that means I’m a dinosaur at the ripe old age of 24 because I still want to rely on polls that talk to actual people. I’m not going to argue that synthetic samples are completely useless. In fact, as I’ll return to later, there is evidence that some techniques can replicate topline survey results quickly and cheaply. But the marketing from certain companies can be slightly optimistic. “No traditional poll will exist by the time the next general election occurs,” said Fink in 2024. We’re just 206 days away from the midterms, and based on the fact that I still have to collect a bunch of polls every day, I’d say he should have run that prediction by a sample of AI agents before the interview.2 To see why synthetic samples can’t replace polls, here’s a quick primer on how they work. The simplest version of these models involves taking a LLM (like ChatGPT or Claude), giving it a demographic profile (e.g., a white, college-educated woman who lives in Utah and makes $70k a year), and then asking it to respond to a survey question. You repeat that process a few thousand times using different demographic profiles and end up with a sample of synthetic survey responses. The actual models used by private companies are more sophisticated than this, usually because they incorporate more hypothesized demographic characteristics for each agent and provide them with extra information. Aaru, for example, feeds agents a diet of news and information they’d be likely to consume, while Electric Twin incorporates their customers’ proprietary data about the audience they’re trying to replicate. The way Ben Warner, the co-founder of Electric Twin, explained it to me was “we have a large amount of data on […] for instance, 5,000 people. Can we make an accurate prediction of how they would respond to another question?” Still, it should be obvious why synthetic samples can’t replace polls. Polling is fundamentally a data collection process. We might use surveys to make predictions by feeding them into election forecasts, but the main purpose of a poll isn’t prediction, it’s gathering new data about what people think and how they feel. Silicon sampling, on the other hand, produces no new data. It’s simply a model: you input LLM training data, demographic prompts, and a bunch of other information, and it spits out a prediction for what a poll would say. We love models here, but models aren’t polls. That difference is an important philosophical sticking point for most pollsters I talk to. “I think politics should stay away from [synthetic sampling], because we’re trying to […] represent the voice of the people,” said Natalie Jackson, a vice president at GQR Insights. Democratic pollster John Hagner told me: “I think I’m just incredibly skeptical of this idea. I don’t think it’s research. At that point, you’re asking the machine to tell you what you already believe.” Hagner has seen some presentations of early synthetic sampling experiments, but so far, “if it’s being used in a campaign, people are keeping it incredibly quiet.”3 But Eli, I hear you saying, aren’t polls themselves increasingly governed by modeling decisions? Indeed they are: pollsters’ choices on which sampling method to use, how to define their likely voter models, and how to weight their samples can and do lead to dramatic differences in the results they publish. Aaru even referenced these limitations in the methodology statement included with that maternal mortality “poll” — although I’m using the term “methodology statement” loosely here, because it doesn’t really explain how the model works at all. We can ignore the (frankly preposterous) implication that synthetic sampling isn’t subject to a separate set of biases. The important point is that there’s still a meaningful difference between using weighting and other statistical techniques on actual polling data and using a model to predict what a poll would say. The latter is far closer to election forecasts or techniques like MRP — potentially useful models, but not a replacement for polls.4 To be fair, other synthetic sampling companies are perfectly happy with the distinction between polls and models. Warner compared polling and synthetic sampling to different tools in a toolbox. “The mistake I think we make is we think that these new tools should either work in exactly the same way or somehow replace these old tools,” he said. “Rather than thinking of it as, okay, so we’ve always had the hammer, we’ve always had the screwdriver, now we’ve got a saw. But don’t use a saw to try [to] do the job of a hammer.” A quick comment from Nate Eli didn’t ask me for a comment — rather rude of him, don’t you think? But since I’m editing this story, I figured I’d add a few quick thoughts rather than putting words in his mouth. Beyond the frequently misleading marketing, what bothers me about the AI “poll” hype is that as AI tools make statistical inference cheaper and/or better (note that these are not synonyms) that actually increases the comparative value of collecting original data. You might be able to train a model to make a reasonable estimate of what some hard-to-reach poll respondent would say — say, a young Black man who voted for Trump. (Such a person checks a number of boxes for a voter who is usually hard to reach in surveys.) Indeed, this is closely related to what models like the Silver Bulletin forecast already do. They essentially smooth out the kinks in noisy survey data by making inferences based on past voting patterns or national polls or surveys of other states. But you don’t actually know what these voters think unless you’re reaching them directly. If there’s a shift in opinion among this subgroup, you’re not going to detect it. So if I were running a campaign, I’d invest more in going the extra mile to find a representative sample of those voters. And then I’d hire some smart quants — or Claude? — to figure out the implications for campaign strategy based on proprietary data that my competitors didn’t have access to. -Nate Silver Are these models any good? If synthetic surveys are just a new type of model, the next obvious question is whether the models are at least accurate. The answer very much depends on who you ask. On one end of the spectrum, you have the maximalist argument that synthetic sampling is more accurate than actual polls. “It’s an incredibly challenging problem to go to someone and say ‘hey, we’re going to be more accurate at predicting human behavior than you, even when you talk to your customers directly’,” Koh recently told CNBC. In his view, synthetic sampling isn’t a saw to polling’s hammer, it’s “magic.” There’s certainly evidence that synthetic samples can replicate certain survey toplines. But if Aaru does have any examples of their approach outperforming the polls, they’re keeping those to themselves.5 Aaru’s 2024 election model, for example, had Kamala Harris leading in Michigan, Nevada, Pennsylvania, and Wisconsin on November 4th. And although they’ve since taken down their forecast page, they gave Harris a 50.5 percent chance of winning the race on November 2nd.6 After the election, Fink told Semafor he was happy enough with those results because they were “within margin of error,” a term that is completely meaningless when applied to a “sample” of AI agents. And of course, Aaru says their models have improved since 2024, so supposedly now they’d be more accurate than the polls? Still, their stronger argument is on cost: “We are significantly faster and cheaper than traditional polling, and still more accurate,” said Fink. The first two claims are undeniably true, but the third brings us to the opposite end of the spectrum. Both Jackson and Hagner are skeptical that these models are reliable for anything beyond replicating common survey toplines. “I just […] don’t think the machines are what we want when we’re looking for nuanced views. My example on this is people in Arizona and Nevada in 2024 who voted for Trump and voted for expanding abortion in their states on ballot initiatives,” said Jackson. Hagner identified another issue. Maybe the synthetic respondents, like sycophantic LLMs, are inhuman in one important way: they’re too nice. “The reports that have come through at the meetings that I’ve been at are that the early experiments on this, they cannot get respondents to be as racist or sexist or, frankly, as negative as human respondents,” he said. Academic research mostly agrees on this point. While there are some papers that show promising results when using LLMs to replicate polling data, most show that LLMs suffer from various quirks like producing too few “don’t know” responses and can seriously overpredict the favorability of politicians like Donald Trump and Kamala Harris. They also seem to struggle with too little variation between demographic subgroups, so the difference in predicted opinion between Democrats and Republicans, for example, is too small. When I asked Warner about these studies, his response to these papers was that just because academics can’t get synthetic sampling to work doesn’t mean that the technique doesn’t work in general. “Actually, the argument is, okay, yours does not [work]. That does not mean […] for this complex set of machinery, which uses a lot of investment, a lot of time, a lot of money, you can’t get it to work.” Cards on the table, I’m somewhat sympathetic to this argument because academics aren’t exactly great at making election forecasts. Usually, the people with skin in the game are the most accurate. Warner’s argument is that the approach Electric Twin takes — which includes, for example, making multiple predictions for each synthetic respondent using different models and prompts and subsequently averaging those to get a final prediction in a sort of ensemble forecast — produces better results than the simpler academic models. Warner shared a comparison between his method and the method from a recent academic paper with me, and Electric Twin was indeed able to get more accurate replication. But even still, he acknowledged that synthetic sampling “is not a crystal ball.” “If you asked me, do I think using other data sources will be more accurate than asking somebody who they will vote for, I would probably say no. But if you asked me ‘would your system be useful for our turnout modeling today?’ I would say yes.” For better or worse, it looks like the method is already getting more popular in the market research world. Most of the clients Aaru touts these days are businesses like EY and McDonald’s. And AI will probably begin to pop up in other parts of the political polling process. Pollsters are already using it to code open-ended survey responses, and some firms, like YouGov, are testing using LLMs to ask survey respondents questions. More worryingly, one danger to actual polls is that AI agents can be used to infiltrate online surveys. Most online polls use various checks to prevent that from happening, but there’s conflicting evidence on how effective those filters are and how prevalent AI agents currently are in online panels. If those agents ever become impossible to detect, it might spell the end of online polling, but the solution isn’t to replace all of your respondents with ChatGPT. Silver Bulletin is a reader-supported publication. To receive new posts and support our work, consider becoming a subscriber. Subscribe 1 That particular poll obviously doesn’t meet Silver Bulletin standards for aggregation. But we exclude all Public Sentiment Institute polls from our averages because we classify them as an amateur polling firm. 2 You could argue that Fink meant the next presidential election, but (a) I’m also confident we’ll still have real polls in 2028 and (b) in that case he should have asked an LLM to define “general election.” 3 Quick caveat: that’s reporting from a Democratic pollster. It’s possible that Republicans are more willing to use AI in political campaigns. 4 Indeed, Silver Bulletin does not include “polls” produced by MRP in our forecasts or averages, and we think it’s extremely misleading when their practitioners describe them in a way that suggests original data had been collected among a large number of states or Congressional districts. 5 A recent report from Aaru and EY did show two examples of a synthetic estimate being closer than a survey to a real-world benchmark — but I’d take those findings with a grain of salt because the report reads more like an ad and didn’t involve any sort of prediction being made ahead of time. 6 For comparison, our odds for Harris on the same day were 48.2 percent.

Apr 11 • 11:38 AM EDT • Technology • natesilver.net

Microbial hockey: Scientists discover how bacteria rotate tiny pucks

At the Institute of Science and Technology Austria (ISTA), Jérémie Palacci's research group is venturing into metallurgy—albeit with a twist. Instead of traditional tools, the scientists use E. coli bacteria, ...

Apr 11 • 10:00 AM EDT • Science • phys.org

CPUID site hijacked to serve malware instead of HWMonitor downloads

: Six-hour breach turned trusted links into a coin toss between legit tools and credential stealers

Apr 10 • 8:53 AM EDT • Technology • theregister.com

Italy's UniCredit considers liquidating Russian banking business, Kommersant reports

Italian bank UniCredit has abandoned plans to sell its Russian unit and is ​considering liquidating the business and relinquishing its ‌banking license in Russia instead, the Kommersant daily reported on Friday, citing unnamed sources.

Apr 10 • 5:01 AM EDT • Business • reuters.com

5 Android phones you should buy instead of the Samsung Galaxy A57

The Galaxy A57 is a really solid Android deal at just $550. But for some people, these five other phones might be better options.

Apr 10 • 5:00 AM EDT • Technology • androidauthority.com

ASUS introduces ROG Equalizer 12V-2x6 cable, ASUS to offer discounted upgrade for existing ROG PSU users

Update: ASUS has clarified that the upgrade program will not include a free cable. Eligible users will instead receive a discount on the ROG Equalizer

Apr 10 • 3:59 AM EDT • Technology • videocardz.com

49ers land Steelers’ 16-sack edge rusher in trade proposal

The 49ers could use their draft capital to upgrade positions of need with veterans instead of rookies.

Apr 10 • 12:15 AM EDT • Sports • sports.yahoo.com

Scientists thought there was a black hole at the centre of our Galaxy. It turns out it may be something even stranger | BBC Sky at Night Magazine

Could Sagittarius A* at the centre of our Milky Way galaxy be not a black hole, but dark matter instead? A new study suggests so.

Apr 9 • 1:13 AM EDT • Science • skyatnightmagazine.com

As the cable business ebbs, AMC Networks takes a new name

The New York-based company wants to emphasize production instead of its traditional TV business.

Apr 8 • 5:48 PM EDT • Business • latimes.com

Scientists say we’ve been wrong about what makes sprinters fast

A new international study is shaking up how we think about elite sprinting, arguing there’s no single “perfect” running style behind the world’s fastest athletes. Instead, speed emerges from a complex mix of an individual’s body, coordination, strength, and training—meaning every top sprinter moves differently. Using examples like rising Australian star Gout Gout, researchers show that unique physical traits can produce world-class speed without copying anyone else’s technique.

Apr 8 • 8:00 AM EDT • Science • sciencedaily.com

'I'm Still Beyond Confused Why They Didn't Go the Cyberpunk Route' — Crimson Desert Female Character Creator Mod Lets Players Unshackle Themselves From Premade Kliff

One of the major criticisms of Crimson Desert I’ve seen since launch is that it does not let you create your own character. Instead, you’re locked into playing as Kliff, who himself has been criticized for a lack of personality, and two other even less fleshed out playable characters. Well, now, like so many other things with Pearl Abyss’ open world action adventure, there’s a mod for that.

Apr 8 • 6:47 AM EDT • Technology • ign.com

Antibacterial products may contribute to dangerous superbug crisis, study suggests

Antibacterial soaps and cleaning wipes may contribute to antimicrobial resistance, a new study suggests, with experts recommending plain soap and water instead.

Apr 7 • 10:43 PM EDT • Health • foxnews.com

Club Corner: Business Professionals of America

The Business Professionals of America on NW Campus is more than just a club. Students also have the opportunity to explore possible future careers through competitive events. The BPA doesn’t hold regular weekly meetings. Instead, students typically meet individually with their faculty mentors as they prepare for regional, state and national competitions. “It is a lot of work,” said BPA adviser Jaye Simpson, an associate professor of accounting and department chair. “They’re working a couple hours every week, usually meeting with their mentor....

Apr 7 • 8:00 PM EDT • Business • collegian.tccd.edu

Viewpoint: FP10 should remain open, excellent and secure

Europe is right to worry about research security. Foreign interference is real. So is the misuse of sensitive knowledge. Universities working in sensitive areas such as AI, quantum, semiconductors and advanced materials cannot afford to ignore the geopolitical environment around them.But Europe is in danger of drawing the wrong conclusion, one that would increase, not reduce, its strategic vulnerabilities.If the EU applies an “EU preference” logic to the next Framework Programme for research and innovation (FP10), it will weaken one of its greatest strategic assets: a research system built on openness, excellence and international collaboration. In the name of security, Europe could end up advancing science more slowly, innovating less effectively and making itself less attractive to global talent and partners in advanced science and technology.That would be a serious mistake.The EU preference included in Article 10 of the proposed European Competitiveness Fund may make sense in some industrial or deployment contexts, but is far harder to justify when applied to collaborative research in advanced science and technology, where excellence and global connectivity are crucial. Research is not procurement. It does not thrive when isolated. It advances through access to the best ideas, the best people, the best facilities and the best data, wherever they are found. This is why FP10 should not simply absorb industrial policy logic by default. Doing so would risk importing instruments that are ill-suited to research and that ultimately increase vulnerability rather than resilience.For universities of science and technology, the issue is especially acute. These institutions sit at the frontier of knowledge and technology creation in the very fields Europe sees as critical for its future competitiveness and resilience. They know better than most that security risks are real. But they also know that openness and security are not opposites. In practice, they have to be made to work together. Research security is not about closing doors. It is about building resilience through collective responsibility, trust, proportionate safeguards and better governance. That is a fundamentally different approach from default restriction.The risks of non-collaborationThe real danger in the current debate is that Europe talks too much about the risks of collaboration and not enough about the risks of non-collaboration. Those risks are strategic too. Cut researchers off from international networks and Europe loses access to knowledge, data, infrastructures and talent. Slow down global collaboration in critical technologies and Europe slows down its own progress on cutting-edge science. Make participation rules unpredictable and Europe weakens its attractiveness to researchers and investors alike.In other words, over-restricting collaboration will create strategic vulnerabilities, particularly in advanced science and technologies.This point is often underestimated in policy discussions that frame openness mainly as a value to be defended. Europe’s scientific strength, technological development and long-term competitiveness depend on remaining connected to the best research ecosystems in the world. For a continent that wants to accelerate deep tech, strengthen industrial capacity and reduce strategic dependencies, weakening the excellence base would be self-defeating. That does not mean ignoring risk. Quite the opposite. Universities are already strengthening due diligence, internal governance, awareness-raising, screening procedures and compliance support. Across Europe, institutions are working to manage risks linked to foreign interference, sanctions, export controls and the misuse of research. The right response is not complacency. It is better risk management. But that means targeted, evidence-based and proportionate measures, not blunt top-down restrictions with wide spillover effects. In the daily reality of universities, openness and restriction often coexist. The real challenge is how to apply safeguards without sliding into securitisation that damages academic freedom, open science and international cooperation. Restrict partners, not nationsMore restrictive treatment of collaborators from European Economic Area members Iceland, Liechtenstein and Norway, or from Switzerland and the UK, is strategically very difficult to justify. These are deeply embedded partners in Europe’s research and innovation ecosystem. Beyond that, Europe should still resist default exclusion and instead rely on case-by-case assessment. The relevant question is not nationality in the abstract. It is the actual risk profile of a collaboration: the institution, the affiliations, the field, the knowledge involved, the intended use and the safeguards available. Screening should focus on institutions and affiliations rather than nationality alone. Related articlesParliament ‘misreads’ link between Horizon Europe and ECF, Commission official saysFrustration grows at governance gap in next Horizon EuropeIf EU preference logic is imported into research without careful calibration, the likely result is a chilling effect. Researchers may step back from legitimate and beneficial collaboration, even where risks are manageable. International partners may see Europe as less predictable. And Europe may end up undermining the very excellence base it needs to compete, scale up and lead in strategic technologies, thereby increasing its dependence on others.FP10 should do the opposite. It should remain open by default, with restrictions used only exceptionally, and then on the basis of clear evidence. It should integrate research security into open science and research integrity frameworks, not set them against each other. And it should recognise that academic freedom, scientific excellence and responsible international collaboration are not obstacles to Europe’s security, they are part of it. Europe needs stronger tools to protect itself. But it also needs the discipline to avoid measures that would weaken it and increase its strategic vulnerabilities in the process. In FP10, that means staying open, excellent and secure.Louise Drogoul is senior advisor for innovation and sustainability at the Cesaer university association.

Apr 7 • 8:00 PM EDT • Science • sciencebusiness.net

Google Brings Vertical Tabs and Improved Reading Mode to Chrome

Google today updated its Chrome browser with support for vertical tabs, which are displayed in a sidebar instead of at the top of the browser. The tab layout can be changed by right clicking on any Chrome window and choosing the "Show Tabs Vertically" option. Sidebar tabs feature full page titles and make it simple to organize tab groups. Google has also added a new full-page interface for reading mode.

Apr 7 • 4:27 PM EDT • Technology • macrumors.com

"The Lakers are a sports car and their answer for everything is more power" - Colin Cowherd says the Lakers prioritized star power over balance and paid for it

Colin Cowherd says the Los Angeles Lakers leaned too heavily on star power instead of building a balanced roster.

Apr 7 • 3:16 AM EDT • Sports • sports.yahoo.com

iPhone Fold Enters Trial Production Phase Ahead of 2026 Launch

Apple partner Foxconn has started trial production on the iPhone Fold, according to Chinese leaker Instant Digital. Trial production comes before mass production, which Apple plans to start in July as long as no issues come up during the earlier testing stage. So far, Apple remains on track to launch the iPhone Fold in 2026, though the latest rumors suggest that it's not going to come out in September. Instead, it could launch sometime after the iPhone 18 Pro, debuting as late as December.

Apr 6 • 5:28 PM EDT • Technology • macrumors.com

When Algorithms Decide: Are Business Schools Preparing Leaders Or Training Managers To Obey Machines?

B-schools are racing to teach AI skills – but they risk producing grads who defer to algorithms instead of leading through them.

Apr 6 • 4:58 PM EDT • Business • poetsandquants.com

“Malcolm in the Middle” star Erik Per Sullivan rejected 'buckets of money' for revival to do this instead

Caleb Ellsworth-Clark will portray Dewey for the revival.

Apr 6 • 1:43 PM EDT • Entertainment • yahoo.com

AI breakthrough cuts energy use by 100x while boosting accuracy

AI is consuming staggering amounts of energy—already over 10% of U.S. electricity—and the demand is only accelerating. Now, researchers have unveiled a radically more efficient approach that could slash AI energy use by up to 100× while actually improving accuracy. By combining neural networks with human-like symbolic reasoning, their system helps robots think more logically instead of relying on brute-force trial and error.

Apr 5 • 8:54 PM EDT • Science • sciencedaily.com

North Shore businesses suffer in aftermath of Kona-low storms

Spring break is typically busy at Sharlyn Foo’s budget accommodations in Haleiwa. But last month, instead of welcoming surfers and families, Foo spent her days canceling reservations, refunding payments and responding to repeated calls from travelers asking whether Oahu’s North Shore was even open.

Apr 5 • 6:04 AM EDT • Business • staradvertiser.com

Commentary: When stars’ plastic surgery is played for your entertainment

Often when I’m scrolling through Instagram, hypnotized by the stream of videos, an actress’ face will cut through the noise. This isn’t a typical clip from a press junket or red carpet. Instead, it will feature side-by-side images of the star, one younger and one more recent. Then a content creator – perhaps a doctor or an aesthetician, sometimes wearing scrubs – will walk me through what cosmetic procedures they think the actress has had. (It’s much rarer that men get this kind of analysis.)

Apr 4 • 9:00 PM EDT • Entertainment • spokesman.com

Gabe Lazo to be UCF head coach instead of assistant under Kim Mulkey

Gabe Lazo will be the next coach of the women's basketball team at UCF. The former Tennessee assistant had initially agreed to work for Kim Mulkey.

Apr 4 • 12:42 PM EDT • Sports • usatoday.com

Scientists built a quantum battery that breaks the rules of charging

Scientists have taken a major step toward futuristic energy tech by building a working prototype of a quantum battery—one that can charge, store, and release energy using the strange rules of quantum physics instead of chemistry. This tiny, laser-powered device hints at a future where energy storage is not only faster but actually improves as systems get larger, flipping the rules of conventional batteries.

Apr 4 • 8:00 AM EDT • Science • sciencedaily.com

Companies are replacing workers instead of hiring more

Recruiters say companies are swapping out employees for more skilled or lower-cost talent as hiring slows and budgets tighten.

Apr 4 • 6:45 AM EDT • Business • businessinsider.com

50-year-old expired salmon found: the shocking discovery that baffles scientists - Futura-Sciences

Unexpected Treasures in Forgotten Cans Decades-old cans tucked away on a shelf might sound like the start of a food safety nightmare, but recently, they’ve become a scientific goldmine instead. In April 2024, the journal Ecology and Evolution published a study that lifted the lid—literally—on an astonishing scientific resource: canned...

Apr 3 • 1:30 PM EDT • Science • futura-sciences.com

White House proposes 12% cut to federal health agencies in 2027 budget request

Congress largely ignored President Trump's previous budget proposal, instead boosting federal health spending.

Apr 3 • 11:35 AM EDT • Health • statnews.com

Far from the Final Four, a protest in track spells out NCAA’s drug-fighting issues across all sports

It was supposed to be a time to celebrate as the top finishers in the NCAA Division III 5,000-meter title race lined up on the eight-tiered podium to receive their trophies. Instead…

Apr 3 • 6:13 AM EDT • Sports • wtop.com

Maui Mental Health Providers Face Stress And Uncertainty About State Jobs

Staff at a state-run clinic serving wildfire survivors in Hawai‘i have waited months for permanent jobs. Instead, they got another temporary contract.

Apr 3 • 6:01 AM EDT • Health • civilbeat.org

Maui Mental Health Providers Face Stress and Uncertainty About State Jobs

Staff at a state-run clinic serving wildfire survivors in Hawaii have waited months for permanent jobs. Instead, they got another temporary contract.

Apr 3 • 4:55 AM EDT • Health • insideclimatenews.org

Scientists Discover Why Flu and COVID Hit Older Adults So Hard

A new study reveals that aging lungs may play a major role in why flu and COVID can become so dangerous for older adults. Researchers found that certain lung cells can trigger an exaggerated immune response, creating clusters of inflammatory cells that end up damaging lung tissue instead of protecting it. In experiments, activating this aging-related signal in young mice caused their lungs to behave like older ones, leading to severe illness.

Apr 2 • 8:00 PM EDT • Science • sciencedaily.com

Strange “elephant skin” rocks reveal ancient life in the dark ocean

A puzzling wrinkled rock formation in Morocco has led scientists to rethink where ancient microbes could live. Instead of shallow, sunlit waters, these microbes may have thrived deep in the ocean, fueled by chemicals delivered by underwater landslides. The discovery suggests that dark, nutrient-rich environments hosted thriving ecosystems much earlier than expected. It also raises the possibility that many similar fossils have been overlooked or misinterpreted.

Apr 2 • 8:00 PM EDT • Science • sciencedaily.com

You can’t really “train” your brain. Here’s what you can do instead.

The best ways to protect your cognitive health might surprise you.

Apr 2 • 4:00 PM EDT • Health • vox.com

Earth’s magnetic field went wild 600 million years ago and scientists finally know why

Hundreds of millions of years ago, Earth’s magnetic field behaved in a way that has long baffled scientists, showing wild and seemingly chaotic shifts unlike anything seen before or since. A new study suggests this chaos may actually hide a deeper pattern: instead of random fluctuations, the magnetic field may have followed a global, organized structure.

Apr 2 • 8:00 AM EDT • Science • sciencedaily.com

Don't Buy the Galaxy S26 Ultra. Get This Phone Seriously Cheap Instead

If you want a Galaxy S26 Ultra but can't quite afford it, shopping the older model is the way to go.

Apr 2 • 6:18 AM EDT • Technology • cnet.com

A 200-year-old light trick just transformed quantum encryption

Scientists have unveiled a new approach to ultra-secure communication that could make quantum encryption simpler and more efficient than ever before. By harnessing a 19th-century optics phenomenon called the Talbot effect, researchers developed a system that sends information using multiple states of single photons instead of just two, dramatically boosting data capacity. Even more impressive, the setup works with standard components and requires only a single detector, reducing cost and complexity.

Apr 1 • 8:00 AM EDT • Science • sciencedaily.com

Apple Adjusts Studio Display XDR Pricing Weeks After Launch

Apple has quietly reduced the price of the Studio Display XDR when configured with the VESA mount adapter, dropping it from $3,299 to $2,899 – a $400 cut. The nano-texture VESA version has also dropped from $3,599 to $3,199. Apple has also reworked the purchasing pattern on its website, making the stand choice the first step in the configuration process instead of the glass selection. When the Studio Display XDR launched last month, both stand options cost the same $3,299.

Apr 1 • 6:40 AM EDT • Technology • macrumors.com

Knoxville City Council rejects alternative response teams

A task force has worked for more than a year on a plan to send mental health experts on low-risk 911 calls instead of police to help those in crisis.

Apr 1 • 5:07 AM EDT • Health • knoxnews.com

Surprising study shows Alzheimer's may start in the body instead of the brain, a discovery that turns medical science upside down

Alzheimer’s disease may begin outside the brain, with inflammation in organs like the skin, lungs, and gut decades before symptoms appear.

Mar 31 • 7:13 PM EDT • Science • earth.com

20-hour Amtrak trip from Chicago to New York: What it's really like

Amid the long TSA wait lines, I took a 20-hour Amtrak trip instead of flying. Perks like easier boarding and comfortable seats made the trip better.

Mar 31 • 2:58 PM EDT • Business • businessinsider.com

Keith White on Reframing Medical Device Marketing for the Modern Healthcare Economy

“Medical device marketing can be regulated and still be exciting,” he explains. “People think the goal here is to sell products, but instead, it’s about proving system-level value.”

Mar 31 • 1:20 PM EDT • Health • usatoday.com

San Marcos arson killing suspect got mental health diversion plan instead of jail

Luis Alvarado, 33, was arrested on charges of murder and arson after the midnight fire in the 900 block of Lacebark Street.

Mar 30 • 4:23 PM EDT • Health • nbcsandiego.com

Navigating the social media minefield

Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.

Mar 29 • 8:00 PM EDT • Science • sciencebusiness.net

Navigating the social media minefield

Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.

Mar 29 • 8:00 PM EDT • Science • sciencebusiness.net

This quantum computing breakthrough may not be what it seemed

A team of physicists set out to test some of the most exciting claims in quantum computing—and found a very different story. Instead of confirming breakthroughs, their careful replication studies revealed that signals once hailed as major advances could actually be explained in simpler ways. Despite the importance of these findings, their work initially struggled to get published, highlighting a deeper issue in science.

Mar 29 • 8:00 AM EDT • Science • sciencedaily.com

The science behind why you can’t lose weight

When you understand what is making you hungry, you can start working with physiology instead of against it.

Mar 28 • 11:00 PM EDT • Science • bigissue.com

Local Newspaper Erodes Community Civic Fabric

The Hawk Eye, Burlington, Iowa's local newspaper, recounts its decline from a community-rooted newsroom that covered a major 1987 grain-elevator explosion to a diminished operation today. Now owned by Gannett after GateHouse consolidation, the paper prints six days a week with only three reporters, outsources layout and printing, and runs syndicated content instead of local reporting. The loss of routine local coverage has eroded civic engagement and community ties.

Mar 28 • 8:58 PM EDT • Science • letsdatascience.com

This new carbon material could make carbon capture far more affordable

Scientists have created a new kind of carbon material that could make carbon capture much cheaper and more efficient. By carefully controlling how nitrogen atoms are arranged, they found certain structures capture CO2 better and release it using far less heat. One version works at temperatures below 60 °C, meaning it could run on waste heat instead of costly energy. The discovery offers a powerful new blueprint for next-generation climate technology.

Mar 28 • 8:00 AM EDT • Science • sciencedaily.com

The Elite 8 begins, plus Tiger’s arrest

Good morning! Make every 0.4 seconds count today. Inside: 📚 Elite 8 storylines 🔢 Hannah Hidalgo did what? Woods arrested after crash Elite Company: Madness, condensed Today, the men’s Elite Eight begins. We considered assembling a matching number of storylines, but the Elite Eight is all about reaching the Final Four, so let’s go with four instead. That might not make total sense, but March is for Madness. Bracket status: The No. 1 seeds: Arizona is the slight favorite per BetMGM. Duke entered t

Mar 28 • 7:31 AM EDT • Sports • sports.yahoo.com

Kim Kardashian's New Energy Drink Promises No Jitters. Does It Live Up to the Hype?

Kim Kardashian has released a new "healthy" energy drink called Update, which contains paraxanthine instead of caffeine. We asked experts about paraxanthine vs. caffeine in Update and how it stacks up against traditional energy drinks.

Mar 28 • 2:46 AM EDT • Health • healthline.com

Scientists discover a hidden system that turns brown fat into a calorie burner

Scientists have identified a key biological system that helps brown fat burn energy by building the networks it needs to function. A protein called SLIT3 splits into two parts, with each piece guiding the growth of blood vessels and nerves inside brown fat. These structures allow the tissue to pull in nutrients and rapidly convert them into heat instead of storing them as fat.

Mar 27 • 8:00 PM EDT • Science • sciencedaily.com

House GOP Leaders Reject Bill to Fund DHS, Likely Extending Standoff

Republicans instead plan to propose an eight-week bill to fund the entire department, including back pay for TSA workers.

Mar 27 • 1:03 PM EDT • Politics • wsj.com

I canceled my flight for a 20-hour Amtrak ride amid TSA airport chaos

TSA chaos and long airport lines pushed me to cancel my flight and take a 20-hour Amtrak ride instead. Here's why I'd do it again.

Mar 27 • 9:00 AM EDT • Business • businessinsider.com

San Francisco's new law could put street food vendors out of business: 'This is our job'

The new law requires San Francisco street vendors to use carts instead of tables that have a handwashing station and fridge - something that can cost $8,000 to $10,000 - money that many vendors say they don't have.

Mar 27 • 1:07 AM EDT • Business • abc7news.com

Google Translate Gets Gemini AI for Smarter Translations and Real-Time Headphone Translation

Google is improving its translation features with Gemini integration, adding AI in search and the Google Translate app. Users can expect smarter and more natural text translations, with improvements to phrases with nuanced meanings. Idioms, local expressions, and slang will be translated with Gemini for improved accuracy, and Gemini will parse context instead of giving a literal word-for-word translation.

Mar 26 • 7:47 PM EDT • Technology • macrumors.com

More concussions equal worse brain health 5 years after college sports

New concussion study deviates from the norm; most research in this space examines people in their 50s or 60s — decades after sport participation. Instead, this U-M study looks at college athletes in their 20s, and researchers already see the impact of concussion, which enables early intervention.

Mar 26 • 4:19 PM EDT • Sports • michigantoday.umich.edu

She taught backyard swim lessons. A single complaint shut them down.

Local governments should encourage home businesses instead of making them illegal.

Mar 25 • 7:00 AM EDT • Business • washingtonpost.com

Russia turned cheap 'Molniya' strike drones into advanced recon tools

The modifications allow Russia to use these drones for battlefield reconnaissance instead of relying on more expensive platforms.

Mar 24 • 11:21 AM EDT • Business • businessinsider.com

Trump administration to pay French company $1B to walk away from US offshore wind leases

The Department of Interior says a French energy company has agreed to give up two U.S. offshore wind leases and invest in fossil fuel projects instead.

Mar 23 • 1:22 PM EDT • Business • click2houston.com

My husband and I were laid off at the same time. Instead of panicking, we started our own business that now has 600 employees.

Mar 23 • 7:21 AM EDT • Business • yahoo.com

Companies Aren’t Ripping Out Business Software for AI. Here’s What They’re Doing Instead.

Tech leaders at large corporations say that, for now, they’re vibe-coding their own small, custom apps, and putting pressure on their software vendors.

Mar 23 • 7:00 AM EDT • Business • wsj.com

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com

The Boston Celtics are terrifying to their opponents again

Instead of mailing it in for a season, the Celtics have rebuilt themselves into a contender again against all odds.

Mar 22 • 2:00 PM EDT • Sports • sports.yahoo.com

Friction without contact discovered as magnetic forces break a 300-year-old law

Researchers have uncovered friction without contact—driven entirely by magnetic interactions. As two magnetic layers slide, their internal forces compete, causing constant rearrangements that dramatically increase resistance at certain distances. This creates a surprising peak in friction instead of a steady rise, breaking a long-standing physics law.

Mar 21 • 8:00 PM EDT • Science • sciencedaily.com

The Joe Kent saga lays bare the real Trump derangement syndrome

Washington's Kent resigning from the nation's security team seemed like an accountability moment. Instead, it demonstrated how President Trump isn't held responsible for anything.

Mar 21 • 9:00 AM EDT • Politics • seattletimes.com

Ancient DNA reveals a farming shift that pushed a society to the brink

A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.

Mar 21 • 8:00 AM EDT • Science • sciencedaily.com

At age 41, a Westmoreland mom of 3 is diagnosed with a cancer that's rising in younger populations

When Misty Ament felt sharp pain in her right side last August, the 41-year-old assumed she was dealing with appendicitis. Instead, doctors discovered...

Mar 21 • 4:00 AM EDT • Health • post-gazette.com

Tectonic shift: Earth was already moving 3.5 billion years ago

Scientists have uncovered the oldest direct evidence yet that Earth’s tectonic plates were on the move 3.5 billion years ago. By analyzing magnetic fingerprints in ancient rocks, they reconstructed how parts of the planet slowly drifted and even rotated over time. This challenges long-standing ideas that early Earth may have had a rigid, unmoving surface. Instead, it suggests the planet was already dynamic—and possibly setting the stage for life—much earlier than expected.

Mar 20 • 8:00 PM EDT • Science • sciencedaily.com

Exclusive: Amazon plans smartphone comeback more than a decade after Fire Phone flop

In 2014, Amazon introduced its first smartphone, hoping to take on Apple and Samsung. Instead, the Fire Phone - overseen directly by founder Jeff Bezos - was scrapped in barely over a year, one of Amazon’s highest-profile flops.

Mar 20 • 6:01 AM EDT • Technology • reuters.com

Scientists turn CO2 into fuel using breakthrough single-atom catalyst

Researchers have created a cutting-edge catalyst that turns CO2 into methanol more efficiently than ever before. Instead of using clumps of metal atoms, they engineered a system where each single indium atom actively drives the reaction. This dramatically reduces energy needs while making the process easier to study and optimize. The result could accelerate the shift toward cleaner fuels and sustainable chemical production.

Mar 19 • 8:00 PM EDT • Science • sciencedaily.com

Justice Department probe of Powell could backfire on Trump and keep Fed chair in office

President Donald Trump has for months wanted to remove Jerome Powell as chair of the Federal Reserve. But instead, an investigation by one of his own officials could end up extending Powell's time at the top of the central bank even after his term formally ends May 15.

Mar 19 • 5:31 PM EDT • Politics • pbs.org

The Science Is in: No One Likes Your Cockapoo

The Science Is in: No One Likes Your Cockapoo: Why not get a cocker spaniel or poodle instead?

Mar 18 • 8:03 PM EDT • Science • nautil.us

Drug smoking can lead to severe burns, complicating harm reduction efforts

Smoking instead of injecting drugs can reduce harm, but a new study shows opioid smokers are four times as likely to suffer severe burns.

Mar 18 • 4:30 AM EDT • Health • statnews.com

Wagoner Community Hospital delays March 13 paychecks, cites soft business deposits

Employees at Wagoner Community Hospital were expecting their March 13th paycheck but instead were notified via email their payroll would be delayed.News Channel

Mar 16 • 10:27 PM EDT • Business • ktul.com

Richard Grenell: From Trump Cabinet Hopeful to Ex-Kennedy Center Manager

Richard Grenell once hoped to be President Trump’s secretary of state. Instead, Mr. Trump just replaced him as Kennedy Center president.

Mar 16 • 8:47 PM EDT • Politics • nytimes.com

Sports gambling was supposed to create new revenue. Instead it's damaging college scholarships

Tennessee's sports gambling tax revenue exceeds $100 million but the state's Lottery-funded scholarship program faces an $80 million deficit.

Mar 16 • 6:02 AM EDT • Sports • tennesseelookout.com

Jane Fonda Questions Why Barbra Streisand Paid Tribute to Robert Redford at Oscars Instead of Her!

Mar 16 • 12:08 AM EDT • Entertainment • etonline.com

Conan O'Brien's Oscars monologue targets TK TK

The comedian kept his opening monologue light and avoided politics, instead acknowledging the devastating wildfires that struck Los Angeles before the ceremony.

Mar 15 • 7:40 PM EDT • Entertainment • latimes.com

CNN liberal panelist argues billions spent on defense should go to health insurance instead

CNN panelists debate U.S. priorities as Leigh McGowan questions whether spending on the Iran conflict should instead go toward addressing healthcare challenges at home.

Mar 15 • 5:25 PM EDT • Health • foxnews.com

Americans are now diagnosing their political opponents instead of understanding them

Psychological interpretation of political disagreement is replacing reasoned debate, leading to a culture of avoidance and echo chambers, and ultimately hindering democracy.

Mar 15 • 12:00 PM EDT • Politics • thehill.com

AMD unveils OpenClaw to run AI agents locally on Ryzen and Radeon hardware

The effort is part of AMD's broader Agent Computer initiative, which argues that the future of AI isn't limited to remote infrastructure. Instead, it envisions a world...

Mar 15 • 10:40 AM EDT • Technology • techspot.com

Denver’s STAR program reduces police contacts and arrests, but can’t meet demand

Denver’s pioneering effort to send mental health clinicians and paramedics to answer some 911 calls instead of police officers now has a proven result.

Mar 15 • 8:00 AM EDT • Health • denverpost.com

THOR AI solves a 100-year-old physics problem in seconds

A new AI framework called THOR is transforming how scientists calculate the behavior of atoms inside materials. Instead of relying on slow simulations that take weeks of supercomputer time, the system uses tensor network mathematics and machine-learning models to solve the problem directly. The approach can compute key thermodynamic properties hundreds of times faster while preserving accuracy. Researchers say this could accelerate discoveries in materials science, physics, and chemistry.

Mar 15 • 8:00 AM EDT • Science • sciencedaily.com

The rise of the daycap: Gen Z prefers intentional, daytime sips

Brands from Absolut to Malibu are reorienting around Gen Z's preference for earlier social drinking occasions instead of late-night bar crawls.

Mar 15 • 4:11 AM EDT • Business • businessinsider.com

Microsoft releases Windows 11 OOB hotpatch to fix RRAS RCE flaw

Microsoft has released an out-of-band (OOB) update to fix a security vulnerabilities affecting Windows 11 Enterprise devices that receive hotpatch updates instead of the regular Patch Tuesday cumulative updates.

Mar 14 • 5:48 PM EDT • Technology • bleepingcomputer.com

Pilates Instructor, 72, Thought She Had the Flu. Then, a 'Shock' Diagnosis from Doctors Changed Everything

Pilates teacher Debi Weiss thought she had flu symptoms, but instead received a 'shock' diagnosis.

Mar 14 • 8:08 AM EDT • Health • people.com

Textbooks were wrong: Scientists reveal the surprising way human hair really grows

Hair may grow in a completely different way than scientists once believed. Instead of being pushed out from the root, new research shows that moving cells inside the follicle actually pull the hair upward like a microscopic motor. Advanced 3D imaging revealed a spiral movement of cells that generates this force. The finding could change how scientists study hair loss and design future treatments.

Mar 14 • 8:00 AM EDT • Science • sciencedaily.com

Small Business Technology News: Musk: X Money Launching In April

Will your customers pay with X? Also, new scams announced by the FBI and Microsoft wants you to hire its agents instead to do tasks.

Mar 14 • 7:00 AM EDT • Business • forbes.com

Islanders vs. Kings Gameday: Line adjustments

The Islanders are back home for a back-to-back, starting with what will hopefully be a vengeance match against the Los Angeles Kings. Coach Patrick Roy has made some line adjustments, putting newcomer Brayden Schenn with Mathew Barzal instead of with Calum Ritchie, the center who his arrival bumped to the wing. Personally, it’s the Palat-Schenn […]

Mar 13 • 6:00 AM EDT • Sports • sports.yahoo.com

A large fossil leg bone hints at T. rex’s origins, but scientists disagree

A new analysis of a large fossil shinbone suggests T. rex ancestors came from North America instead of Asia. Not everyone agrees.

Mar 12 • 12:00 PM EDT • Science • sciencenews.org