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Neandertals may have hunted and eaten outsiders, chilling cannibalism study finds

A cave in Belgium has revealed unsettling evidence that Neandertals selectively cannibalized outsiders, focusing on women and children. The victims weren’t from the local group and appear to have been treated like prey, with bones butchered for meat and marrow. This suggests the behavior wasn’t ritual, but practical—or possibly linked to intergroup conflict. The discovery paints a darker, more complex picture of Neandertal life during their final millennia.

Apr 12 • 8:00 AM EDT • Science • sciencedaily.com

“AI polls” are fake polls

A few weeks after Donald Trump’s second presidential win, I took the train up from London (where I was living at the time) to Oxford to attend a conference on polls and forecasts of the 2024 election. Most of the attendees were pollsters or academics, but I also watched presentations from Aaru and Electric Twin, two companies that do what is interchangeably called synthetic sampling, silicon sampling, or synthetic audiences. Stripped of startup jargon, that means they use large language models (LLMs) to simulate responses to public opinion polls by having AI agents take on the role of survey respondents. I had already heard of Aaru thanks to some articles with eye-catching headlines like “No people, no problem: AI chatbots predict elections better than humans” in the months leading up to Election Day. The founders were making some big, some might even say far-fetched claims, such as: “within two years, we will simulate the entire globe — from the way crops are grown in Ukraine to how that impacts production of oil in Iraq, trade through the strait of Malacca, and elections for the mayor of Baltimore.” When Semafor asked Aaru’s cofounders — Cameron Fink and Ned Koh — about my boss, they said “we respect all those who came before us.” Nate (as he so often does) shared his thoughts on Twitter: Fink and Koh were relatively good-natured about this back-and-forth when we spoke at Oxford. They even offered to mail me one of the t-shirts featuring Nate’s quote they apparently had made. I never took them up on the offer, which I now somewhat regret. These synthetic sampling companies fell off my radar for a while, but they do still exist. In fact, Aaru recently received a $1 billion valuation. Is what they’re doing anywhere close to the most important frontier in AI development? Not by a longshot, especially when Anthropic just developed a model so adept at exploiting software vulnerabilities that it’s only being released to 40 companies. Still, silicon sampling is increasingly finding its way into public polling. Axios reported in March that “a majority of people trust their own doctors and nurses” based on findings from Aaru — without mentioning that the “people” in that sentence were actually LLMs. Around the same time, the Public Sentiment Institute “boosted” their online sample of 373 real survey respondents with 114 AI agents.1 (Spoiler alert: even the co-founder of Electric Twin doesn’t think that’s a particularly defensible approach.) Polling companies like Qualtrics and Ipsos are also developing synthetic data panels. So, what should we make of these … “polls”? Let’s get one thing out of the way: whatever they are, they’re not polls in the way that term is usually defined. Subscribe You can’t replace polls with AI On one hand, using LLMs to essentially make up fake survey respondents sort of sounds like the dumbest idea ever, one that will at best imperfectly replicate real polls while introducing all sorts of biases. On the other hand, with LLMs improving at a remarkable, perhaps even alarming rate, maybe that means I’m a dinosaur at the ripe old age of 24 because I still want to rely on polls that talk to actual people. I’m not going to argue that synthetic samples are completely useless. In fact, as I’ll return to later, there is evidence that some techniques can replicate topline survey results quickly and cheaply. But the marketing from certain companies can be slightly optimistic. “No traditional poll will exist by the time the next general election occurs,” said Fink in 2024. We’re just 206 days away from the midterms, and based on the fact that I still have to collect a bunch of polls every day, I’d say he should have run that prediction by a sample of AI agents before the interview.2 To see why synthetic samples can’t replace polls, here’s a quick primer on how they work. The simplest version of these models involves taking a LLM (like ChatGPT or Claude), giving it a demographic profile (e.g., a white, college-educated woman who lives in Utah and makes $70k a year), and then asking it to respond to a survey question. You repeat that process a few thousand times using different demographic profiles and end up with a sample of synthetic survey responses. The actual models used by private companies are more sophisticated than this, usually because they incorporate more hypothesized demographic characteristics for each agent and provide them with extra information. Aaru, for example, feeds agents a diet of news and information they’d be likely to consume, while Electric Twin incorporates their customers’ proprietary data about the audience they’re trying to replicate. The way Ben Warner, the co-founder of Electric Twin, explained it to me was “we have a large amount of data on […] for instance, 5,000 people. Can we make an accurate prediction of how they would respond to another question?” Still, it should be obvious why synthetic samples can’t replace polls. Polling is fundamentally a data collection process. We might use surveys to make predictions by feeding them into election forecasts, but the main purpose of a poll isn’t prediction, it’s gathering new data about what people think and how they feel. Silicon sampling, on the other hand, produces no new data. It’s simply a model: you input LLM training data, demographic prompts, and a bunch of other information, and it spits out a prediction for what a poll would say. We love models here, but models aren’t polls. That difference is an important philosophical sticking point for most pollsters I talk to. “I think politics should stay away from [synthetic sampling], because we’re trying to […] represent the voice of the people,” said Natalie Jackson, a vice president at GQR Insights. Democratic pollster John Hagner told me: “I think I’m just incredibly skeptical of this idea. I don’t think it’s research. At that point, you’re asking the machine to tell you what you already believe.” Hagner has seen some presentations of early synthetic sampling experiments, but so far, “if it’s being used in a campaign, people are keeping it incredibly quiet.”3 But Eli, I hear you saying, aren’t polls themselves increasingly governed by modeling decisions? Indeed they are: pollsters’ choices on which sampling method to use, how to define their likely voter models, and how to weight their samples can and do lead to dramatic differences in the results they publish. Aaru even referenced these limitations in the methodology statement included with that maternal mortality “poll” — although I’m using the term “methodology statement” loosely here, because it doesn’t really explain how the model works at all. We can ignore the (frankly preposterous) implication that synthetic sampling isn’t subject to a separate set of biases. The important point is that there’s still a meaningful difference between using weighting and other statistical techniques on actual polling data and using a model to predict what a poll would say. The latter is far closer to election forecasts or techniques like MRP — potentially useful models, but not a replacement for polls.4 To be fair, other synthetic sampling companies are perfectly happy with the distinction between polls and models. Warner compared polling and synthetic sampling to different tools in a toolbox. “The mistake I think we make is we think that these new tools should either work in exactly the same way or somehow replace these old tools,” he said. “Rather than thinking of it as, okay, so we’ve always had the hammer, we’ve always had the screwdriver, now we’ve got a saw. But don’t use a saw to try [to] do the job of a hammer.” A quick comment from Nate Eli didn’t ask me for a comment — rather rude of him, don’t you think? But since I’m editing this story, I figured I’d add a few quick thoughts rather than putting words in his mouth. Beyond the frequently misleading marketing, what bothers me about the AI “poll” hype is that as AI tools make statistical inference cheaper and/or better (note that these are not synonyms) that actually increases the comparative value of collecting original data. You might be able to train a model to make a reasonable estimate of what some hard-to-reach poll respondent would say — say, a young Black man who voted for Trump. (Such a person checks a number of boxes for a voter who is usually hard to reach in surveys.) Indeed, this is closely related to what models like the Silver Bulletin forecast already do. They essentially smooth out the kinks in noisy survey data by making inferences based on past voting patterns or national polls or surveys of other states. But you don’t actually know what these voters think unless you’re reaching them directly. If there’s a shift in opinion among this subgroup, you’re not going to detect it. So if I were running a campaign, I’d invest more in going the extra mile to find a representative sample of those voters. And then I’d hire some smart quants — or Claude? — to figure out the implications for campaign strategy based on proprietary data that my competitors didn’t have access to. -Nate Silver Are these models any good? If synthetic surveys are just a new type of model, the next obvious question is whether the models are at least accurate. The answer very much depends on who you ask. On one end of the spectrum, you have the maximalist argument that synthetic sampling is more accurate than actual polls. “It’s an incredibly challenging problem to go to someone and say ‘hey, we’re going to be more accurate at predicting human behavior than you, even when you talk to your customers directly’,” Koh recently told CNBC. In his view, synthetic sampling isn’t a saw to polling’s hammer, it’s “magic.” There’s certainly evidence that synthetic samples can replicate certain survey toplines. But if Aaru does have any examples of their approach outperforming the polls, they’re keeping those to themselves.5 Aaru’s 2024 election model, for example, had Kamala Harris leading in Michigan, Nevada, Pennsylvania, and Wisconsin on November 4th. And although they’ve since taken down their forecast page, they gave Harris a 50.5 percent chance of winning the race on November 2nd.6 After the election, Fink told Semafor he was happy enough with those results because they were “within margin of error,” a term that is completely meaningless when applied to a “sample” of AI agents. And of course, Aaru says their models have improved since 2024, so supposedly now they’d be more accurate than the polls? Still, their stronger argument is on cost: “We are significantly faster and cheaper than traditional polling, and still more accurate,” said Fink. The first two claims are undeniably true, but the third brings us to the opposite end of the spectrum. Both Jackson and Hagner are skeptical that these models are reliable for anything beyond replicating common survey toplines. “I just […] don’t think the machines are what we want when we’re looking for nuanced views. My example on this is people in Arizona and Nevada in 2024 who voted for Trump and voted for expanding abortion in their states on ballot initiatives,” said Jackson. Hagner identified another issue. Maybe the synthetic respondents, like sycophantic LLMs, are inhuman in one important way: they’re too nice. “The reports that have come through at the meetings that I’ve been at are that the early experiments on this, they cannot get respondents to be as racist or sexist or, frankly, as negative as human respondents,” he said. Academic research mostly agrees on this point. While there are some papers that show promising results when using LLMs to replicate polling data, most show that LLMs suffer from various quirks like producing too few “don’t know” responses and can seriously overpredict the favorability of politicians like Donald Trump and Kamala Harris. They also seem to struggle with too little variation between demographic subgroups, so the difference in predicted opinion between Democrats and Republicans, for example, is too small. When I asked Warner about these studies, his response to these papers was that just because academics can’t get synthetic sampling to work doesn’t mean that the technique doesn’t work in general. “Actually, the argument is, okay, yours does not [work]. That does not mean […] for this complex set of machinery, which uses a lot of investment, a lot of time, a lot of money, you can’t get it to work.” Cards on the table, I’m somewhat sympathetic to this argument because academics aren’t exactly great at making election forecasts. Usually, the people with skin in the game are the most accurate. Warner’s argument is that the approach Electric Twin takes — which includes, for example, making multiple predictions for each synthetic respondent using different models and prompts and subsequently averaging those to get a final prediction in a sort of ensemble forecast — produces better results than the simpler academic models. Warner shared a comparison between his method and the method from a recent academic paper with me, and Electric Twin was indeed able to get more accurate replication. But even still, he acknowledged that synthetic sampling “is not a crystal ball.” “If you asked me, do I think using other data sources will be more accurate than asking somebody who they will vote for, I would probably say no. But if you asked me ‘would your system be useful for our turnout modeling today?’ I would say yes.” For better or worse, it looks like the method is already getting more popular in the market research world. Most of the clients Aaru touts these days are businesses like EY and McDonald’s. And AI will probably begin to pop up in other parts of the political polling process. Pollsters are already using it to code open-ended survey responses, and some firms, like YouGov, are testing using LLMs to ask survey respondents questions. More worryingly, one danger to actual polls is that AI agents can be used to infiltrate online surveys. Most online polls use various checks to prevent that from happening, but there’s conflicting evidence on how effective those filters are and how prevalent AI agents currently are in online panels. If those agents ever become impossible to detect, it might spell the end of online polling, but the solution isn’t to replace all of your respondents with ChatGPT. Silver Bulletin is a reader-supported publication. To receive new posts and support our work, consider becoming a subscriber. Subscribe 1 That particular poll obviously doesn’t meet Silver Bulletin standards for aggregation. But we exclude all Public Sentiment Institute polls from our averages because we classify them as an amateur polling firm. 2 You could argue that Fink meant the next presidential election, but (a) I’m also confident we’ll still have real polls in 2028 and (b) in that case he should have asked an LLM to define “general election.” 3 Quick caveat: that’s reporting from a Democratic pollster. It’s possible that Republicans are more willing to use AI in political campaigns. 4 Indeed, Silver Bulletin does not include “polls” produced by MRP in our forecasts or averages, and we think it’s extremely misleading when their practitioners describe them in a way that suggests original data had been collected among a large number of states or Congressional districts. 5 A recent report from Aaru and EY did show two examples of a synthetic estimate being closer than a survey to a real-world benchmark — but I’d take those findings with a grain of salt because the report reads more like an ad and didn’t involve any sort of prediction being made ahead of time. 6 For comparison, our odds for Harris on the same day were 48.2 percent.

Apr 11 • 11:38 AM EDT • Technology • natesilver.net

WesternU College of Pharmacy’s Ray Symposium examines keys to regain trust in science

Dr. Aaron E. Carroll, President & CEO of AcademyHealth, presented “Science You Can Trust: Leading with Evidence in a Distrustful Time” at the 20th annual Ray Symposium at WesternU.

Apr 10 • 12:16 PM EDT • Science • news.westernu.edu

Student-Led Fresh Check Day Promotes Importance of Student Mental Health - University of New Haven

A public health capstone course empowers students to design and lead an evidence-based mental health initiative, building peer-to-peer support and enriching campus awareness and suicide prevention readiness.

Apr 10 • 8:00 AM EDT • Health • newhaven.edu

When and why political leaders polarise rhetoric: Evidence from Twitter/X

Standard theories of electoral competition predict that politicians should converge toward the centre as elections approach. This column challenges this prediction, using 3.4 million tweets from 367 political leaders across 21 Western democracies. Rhetorical polarisation between populist and non-populist leaders rises sharply in the two quarters before an election and reverts to average levels once it is over. Both groups adopt a more emotionally direct communication style as elections near, but they increasingly talk about different topics. The findings suggest that social media turns electoral campaigns into an engine of political polarisation.

Apr 9 • 7:39 PM EDT • Politics • cepr.org

More women in politics does not always mean more gender equality

Evidence on the policy impact of female politicians is mixed. This column uses data on bills sponsored in the Italian House of Representatives between 1987 and 2022 to show how female politicians’ engagement with women’s issues is systematically related to the gender norms of the environments in which they were born. The findings suggest that while increasing the number of women in politics remains essential to broaden representation and diversify policy priorities, if social norms remain traditional, progress on gender equality may still be slow.

Apr 9 • 7:39 PM EDT • Politics • cepr.org

Scientists Announce The First Clear Evidence of a Chimpanzee 'Civil War'

It's exceedingly rare.

Apr 9 • 2:00 PM EDT • Science • sciencealert.com

3L Rachel Sadler Charts Path in Brain Health, Technology, and Policy Through UC Law SF’s Health Law Concentration   - UC Law San Francisco (Formerly UC Hastings)

3L Rachel Sadler studies health law and policy at UC Law SF while researching the legal implications of neurotechnology and other emerging tools that may affect human cognition. 3L student Rachel Sadler shares how UC Law SF’s Health Law Concentration prepared her for a career focused on the intersection of brain health, government policy, and technology. Gained a detailed understanding of how U.S. health care is regulated and where policy reform is needed through coursework and research. Interned with state and federal agencies that regulate health care services and worked with a major health care provider’s bioethics department. Plans to pursue a career focused on protecting cognitive liberty and mental privacy as new technologies reshape healthcare. 3L Rachel Sadler: The Health Law Concentration has given me fluency in one of the most complex regulated industries and the tools to become an effective advocate for better health policy. Before coming to law school, I spent a decade teaching and working with teachers and administrators on high school programming for multilingual learners. Healthcare kept emerging as the most powerful driver of student outcomes. I wanted to understand how to make effective policy change in this area and how to use existing law to defend people’s health rights in California. Through the concentration’s coursework, I gained a sophisticated understanding of how U.S. healthcare is regulated. I also learned where the pressure points for reform exist. The courses gave me space to develop what became my central research interest: how law and policy can be built to protect human cognition and healthy brain development, particularly regarding new technologies such as generative AI and neurotechnology. The health law faculty were instrumental in that process, genuinely invested in helping me and other students define and pursue our own intellectual vision. During law school, I interned at the General Counsel’s Office for Region IX of the U.S. Department of Health and Human Services. I also externed at the California Department of Justice’s Health, Education and Welfare Division. Additionally, I externed at Kaiser Permanente Northern California’s Bioethics Department. Alongside those placements, I conducted extensive independent research on mental privacy and emerging neurotechnology, working closely with Professors Emily Murphy and George Horvath. That research became the throughline of my law school experience and the foundation of my current policy focus. I must also credit Nicole Ozer of the Center for Constitutional Democracy (CCD), whose deep knowledge of California privacy law and the public-interest privacy landscape deeply informed my work. I currently serve a research assistant with the CCD, where I spearhead the development of K-12 educational resources in partnership with law faculty and students. I’ve found UC Law SF to be an ideal place for second-career, nontraditional students. There is a tremendous diversity of life and career experience here, and I felt fully welcomed into the community, despite returning as a student at a different stage of life. I came to law school wanting to promote equity in California’s healthcare system. I am leaving with a sharper and more specific ambition: to build a policy career focused on protecting cognitive liberty and mental privacy from technological intrusion. This is both an urgent and underserved area of law, and I want to be part of defining this landscape going forward. Whether as a practicing attorney or a policy advisor, I plan to work on these issues after law school. I strongly recommend UC Law SF and the Health Law Concentration. When I arrived in law school, I worried the concentration would be narrow and that my non-clinical background would be a disadvantage. The opposite was true. The health law faculty thinks about health expansively, encompassing social determinants of health, structural inequity, and emerging technologies alongside the regulatory mechanics of the industry. The faculty are accessible, intellectually generous, and genuinely invested in students’ development. I found my research vision here, and I deeply appreciate the concentration’s role in this. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.

Apr 9 • 11:00 AM EDT • Health • uclawsf.edu

Why colluding with King Donald’s insanity is the only game in town

The madness is contagious – and nowhere has this been more in evidence than in the two-week ceasefire with Iran

Apr 9 • 10:38 AM EDT • Politics • theguardian.com

Abortion Pill’s Safety Called into Question in Congressional Actions Based on Misleading Data — The Monitor

False claims about the safety of mifepristone are driving legislative and investigative action in Congress, even as major medical organizations and decades of clinical evidence support the drug’s safety. And competing interpretations of what censorship and free speech mean are impacting how health misinformation is moderated.

Apr 9 • 8:00 AM EDT • Health • kff.org

No Charges for Wisconsin Mayor Who Removed Ballot Drop Box in 2024

A special prosecutor said a review of the incident found there was not sufficient evidence to charge Doug Diny, the mayor of Wausau.

Apr 8 • 10:14 PM EDT • Politics • nytimes.com

Viewpoint: FP10 should remain open, excellent and secure

Europe is right to worry about research security. Foreign interference is real. So is the misuse of sensitive knowledge. Universities working in sensitive areas such as AI, quantum, semiconductors and advanced materials cannot afford to ignore the geopolitical environment around them.But Europe is in danger of drawing the wrong conclusion, one that would increase, not reduce, its strategic vulnerabilities.If the EU applies an “EU preference” logic to the next Framework Programme for research and innovation (FP10), it will weaken one of its greatest strategic assets: a research system built on openness, excellence and international collaboration. In the name of security, Europe could end up advancing science more slowly, innovating less effectively and making itself less attractive to global talent and partners in advanced science and technology.That would be a serious mistake.The EU preference included in Article 10 of the proposed European Competitiveness Fund may make sense in some industrial or deployment contexts, but is far harder to justify when applied to collaborative research in advanced science and technology, where excellence and global connectivity are crucial. Research is not procurement. It does not thrive when isolated. It advances through access to the best ideas, the best people, the best facilities and the best data, wherever they are found. This is why FP10 should not simply absorb industrial policy logic by default. Doing so would risk importing instruments that are ill-suited to research and that ultimately increase vulnerability rather than resilience.For universities of science and technology, the issue is especially acute. These institutions sit at the frontier of knowledge and technology creation in the very fields Europe sees as critical for its future competitiveness and resilience. They know better than most that security risks are real. But they also know that openness and security are not opposites. In practice, they have to be made to work together. Research security is not about closing doors. It is about building resilience through collective responsibility, trust, proportionate safeguards and better governance. That is a fundamentally different approach from default restriction.The risks of non-collaborationThe real danger in the current debate is that Europe talks too much about the risks of collaboration and not enough about the risks of non-collaboration. Those risks are strategic too. Cut researchers off from international networks and Europe loses access to knowledge, data, infrastructures and talent. Slow down global collaboration in critical technologies and Europe slows down its own progress on cutting-edge science. Make participation rules unpredictable and Europe weakens its attractiveness to researchers and investors alike.In other words, over-restricting collaboration will create strategic vulnerabilities, particularly in advanced science and technologies.This point is often underestimated in policy discussions that frame openness mainly as a value to be defended. Europe’s scientific strength, technological development and long-term competitiveness depend on remaining connected to the best research ecosystems in the world. For a continent that wants to accelerate deep tech, strengthen industrial capacity and reduce strategic dependencies, weakening the excellence base would be self-defeating. That does not mean ignoring risk. Quite the opposite. Universities are already strengthening due diligence, internal governance, awareness-raising, screening procedures and compliance support. Across Europe, institutions are working to manage risks linked to foreign interference, sanctions, export controls and the misuse of research. The right response is not complacency. It is better risk management. But that means targeted, evidence-based and proportionate measures, not blunt top-down restrictions with wide spillover effects. In the daily reality of universities, openness and restriction often coexist. The real challenge is how to apply safeguards without sliding into securitisation that damages academic freedom, open science and international cooperation. Restrict partners, not nationsMore restrictive treatment of collaborators from European Economic Area members Iceland, Liechtenstein and Norway, or from Switzerland and the UK, is strategically very difficult to justify. These are deeply embedded partners in Europe’s research and innovation ecosystem. Beyond that, Europe should still resist default exclusion and instead rely on case-by-case assessment. The relevant question is not nationality in the abstract. It is the actual risk profile of a collaboration: the institution, the affiliations, the field, the knowledge involved, the intended use and the safeguards available. Screening should focus on institutions and affiliations rather than nationality alone. Related articlesParliament ‘misreads’ link between Horizon Europe and ECF, Commission official saysFrustration grows at governance gap in next Horizon EuropeIf EU preference logic is imported into research without careful calibration, the likely result is a chilling effect. Researchers may step back from legitimate and beneficial collaboration, even where risks are manageable. International partners may see Europe as less predictable. And Europe may end up undermining the very excellence base it needs to compete, scale up and lead in strategic technologies, thereby increasing its dependence on others.FP10 should do the opposite. It should remain open by default, with restrictions used only exceptionally, and then on the basis of clear evidence. It should integrate research security into open science and research integrity frameworks, not set them against each other. And it should recognise that academic freedom, scientific excellence and responsible international collaboration are not obstacles to Europe’s security, they are part of it. Europe needs stronger tools to protect itself. But it also needs the discipline to avoid measures that would weaken it and increase its strategic vulnerabilities in the process. In FP10, that means staying open, excellent and secure.Louise Drogoul is senior advisor for innovation and sustainability at the Cesaer university association.

Apr 7 • 8:00 PM EDT • Science • sciencebusiness.net

Executive Summary: A Patients’ Bill of Rights To Lower Health Care Costs

CAP’s plan would limit unjustified premium increases; reduce deductibles by reining in outlier hospital prices; and replace prior authorization with independent, evidence-based clinical review to lower health care costs and increase access to timely care.

Apr 7 • 6:45 PM EDT • Health • americanprogress.org

The Artemis II mission reveals glory of God

Discoveries in physics, astronomy and biology — from the Big Bang to DNA code — challenge science-based atheism and point to evidence of a cosmic plan.

Apr 7 • 4:23 PM EDT • Science • foxnews.com

Why Do Deliberative Discussions Reduce Affective Polarization? Evidence from a Deliberation Experiment in Honduras - April 7, 2026

Deliberative democracy advocates argue that deliberation can strengthen democracy in part by reducing partisan hostility and affective polarization. Yet - Why Do Deliberative Discussions Reduce Affective Polarization? Evidence from a Deliberation Experiment in Honduras April 7, 2026

Apr 7 • 1:56 PM EDT • Politics • schaeffer.usc.edu

The Boundless Deep: Young Tennyson, Science, and the Crisis of Belief by Richard Holmes

Pantheon Review by Walter Cummins The image of Alfred Tennyson I’ve carried for decades goes back to the childhood card game of Authors that depicts him with a stately continence sharpened by a jutting black beard. He’s formidable, his aura superior. Holmes opens his biography of the youthful Tennyson by describing the similar formality of the imposing Tennyson statue at Trinty College Cambridge, sharing the honor with other Trinity greats, including Isaac Newton, Francis Bacon, and Thomas Babington Macaulay. Holmes doesn’t want to chip away at that statue but rather reveal its inner youthful core of the man—tall, handsome, and talented but unformed, emerging from a disturbed family of addicted or insane male siblings and four unusual sisters struggling under a violent alcoholic clergyman father. Alfred was certainly statuesque, but would he end up a block of unformed stone like his equally promising brothers? He was youngest of three equally regarded Tennyson brothers at Cambridge, all bright, handsome, and talented, in fact Alfred regarded by some as less promising than his elders who also wrote poetry. Yet Alfred wrote one of his major poems, “The Kraken,” at twenty, revealing both his talent, his interest in geological forces, and the haunting creature that embodied his anxieties. While Holmes focuses on Tennyson of the 1830s and 1840s, he can’t tell his story without exploring his involvement with the Victorian intellectual upheaval. Tennyson was fascinated by new scientific perspectives, following the latest findings as soon as books and articles were published. He was especially taken with Charles Lyell’s deep studies of geology and the discovery of fossils and a timeline of the planet’s development that did much to question fundamental religious assumptions. The impact of these discoveries is reflected in Tennyson’s poetry and led to the crisis in belief he shared with so many contemporaries. He was especially taken by the cycles of destruction and renewal that informed the struggles he confronted in In Memoriam, Maud, and Idylls of the King. Tennyson was only one of the eventual major figures at Cambridge at the same time, young men just beginning to realize their potential. Charles Darwin was at Christ College, although there is no evidence that he and Tennyson even met as students or later in life. Yet evolution became significant in Tennyson’s thinking and the issues of his poetry. One of Tennyson’s best and most important Cambridge friends was Edward FitzGerald, who became the translator of The Rubáiyát of Omar Khayyám and in their on and off relationship served as Tennyson’s harshest critic. FitzGerald was also a friend of the novelist William Makepeace Thackeray, the two of them partying in Paris as undergraduates. That connection led to a friendship between Thackeray and Tennyson. Others who came to play significant roles in Tennyson’s life were Thomas Carlyle, the Brownings, and the Pre-Raphaelites. Tennyson’s deepest friend at college was Arthur Hallam, who at twenty wrote a glowing review of Tennyson’s first poetry collection, travelled on European adventures with him, and fell in love with his sister Emily. Hallam was also regarded as one more very promising Cambridge student. His sudden death at twenty-two in Vienna from a stroke while travelling with his father devastated many friends, but perhaps Tennyson most of all. He did not write immediate poems of grief but took years to compile those collected in In Memoriam A.H.H., published in 1850, almost twenty years after Hallam’s death For all of Tennyson’s early poetic successes and successes, Holmes reveals him as an often troubled young man suffering periods of depression, fearing planetary upheaval, concerned about supporting himself, disappointed in romances, and worried that he would inherit the family’s mental illness tendencies. Yet despite his seeming withdrawals, he was always writing poetry that he kept private and would not let go, constantly revising. 1850 became a transformative year for Tennyson. He finally consented to publishing In Memoriam with a last-minute prologue that acknowledged God and perhaps convinced the religious Emily Sellwood to marry him after years of pursuit.. He opened up to Emily, revealing his struggles with fears of depression and “weird seizures.” The devastating event of that time was the stillborn death of his unnamed first son. It shook him, but Emily’s faith brought them closer and convinced him to believe in an afterlife. Two later sons survived. With the death of William Wordworth in April of 1950, Tennyson was named poet laureate at age forty-one, reluctantly accepting. It’s as if Tennyson’s life split in half in that year. He lived another forty years, now a recognized success, with the prestige of being an official poet writing patriotic verse, wealthy and revered, no longer the insecure young man seeking an outlet for his immense talent. He earned a place in the Authors deck, now dignified and in 1884 elevated to the peerage as Arthur, Lord Tennyson. Richard Holmes is the author of twenty previous books on the Romantics and Victorians, several of which received awards. The Boundless Deep was shortlisted for the 2025 Baillie Gifford Prize for Non-Fiction. He captures the complex vicissitudes of Tennyson’s youth, illustrated by frequent excerpts from the poetry, placing that life in the full context of the shattering discoveries that led to an upheaval of thought in the Victorian age.

Apr 7 • 12:35 PM EDT • Science • calirb.com

If you cap insulin at $35 a month, people with type 2 diabetes stick to treatment, study finds

$35 insulin, more evidence abortion meds are safe OTC, and other health news from Morning Rounds

Apr 7 • 8:43 AM EDT • Health • statnews.com

Leading with Science and Evidence in a Time of Retreat

As global resources become more constrained, evidence-based tools that guide investments toward maximum impact are more important than ever. This World Health Day, the WHO urges the world to embrace evidence, support science-led solutions, and advance global cooperation to turn evidence into action.

Apr 7 • 7:40 AM EDT • Science • nti.org

The Blogs: The Difference Between Ideological “Research” and Evidence-Based Science

From the blog of Monique Dietvorst at The Times of Israel

Apr 7 • 12:11 AM EDT • Science • blogs.timesofisrael.com

World Health Day 2026: Together for health. Stand with science

On World Health Day 2026, celebrated on 7 April, WHO unites and mobilizes the world under the theme “Together for health. Stand with science.” celebrating the power of scientific collaboration to protect the health of people, animals, plants, and the planet. The year‑long campaign spotlights both scientific achievements and the multilateral cooperation needed to turn evidence into action.

Apr 6 • 8:00 PM EDT • Health • who.int

Dem ADMITS party 'lost the plot' amid woke politics push

2028 Democratic contenders are distancing themselves from 'woke' rhetoric, with Gov. Gavin Newsom claiming his office never used the term 'Latinx' despite video evidence as Rahm Emanuel admits the party is on the 'losing side' of the culture war.

Apr 6 • 1:56 PM EDT • Politics • foxnews.com

Bridging Gaps in Mental Health Care: A Multi-country Research Initiative

By combining cutting-edge digital technologies with rigorous evidence across countries, BRIDGE-MH aims to transform how mental health needs are identified and addressed in humanitarian settings.

Apr 6 • 11:22 AM EDT • Health • worldbank.org

Public Health Education in an Uncertain World: Training Leaders Guided by Evidence and Empathy

Public health education trains professionals to prevent crises and advance community health, all while emphasizing humanity.

Apr 6 • 11:12 AM EDT • Health • news.med.miami.edu

Standing with Science in a Post-Truth World

Scientific progress against emerging threats will matter only if societies can defend trust in evidence from the distortions of the post-truth age

Apr 6 • 9:05 AM EDT • Science • orfonline.org

RFK Jr, EPA chief 'declare war' on microplastics amid growing evidence of health risks

Health and Human Services Secretary RFK Jr. and EPA Administrator Lee Zeldin are declaring a war on microplastics.

Apr 5 • 4:03 PM EDT • Health • fox5atlanta.com

RFK Jr, EPA chief 'declare war' on microplastics amid growing evidence of health risks

Health and Human Services Secretary RFK Jr. and EPA Administrator Lee Zeldin are declaring a war on microplastics.

Apr 5 • 4:03 PM EDT • Health • ktvu.com

RFK Jr, EPA chief 'declare war' on microplastics amid growing evidence of health risks

RFK Jr. and the EPA head "declare war" on microplastics, adding them to the drinking water contaminants list and launching new health studies.

Apr 5 • 12:33 AM EDT • Health • foxnews.com

This exploding star was spotted doing something weird. Now scientists think it might have solved a key cosmic theory | BBC Sky at Night Magazine

New evidence proves these magnetic monsters are the secret engines behind the Universe’s biggest explosions

Apr 4 • 7:21 AM EDT • Science • skyatnightmagazine.com

Scientists find evidence for theorized gargantuan star explosions

A supernova is always violent, but some supernovas may be so immensely powerful they leave absolutely nothing behind.

Apr 3 • 6:33 PM EDT • Science • ksl.com

We all need to become better science storytellers. Here’s why and how.

Last week, in a lovely New Haven bar, six people gathered in front of a crowd to tell stories that were somehow related to science and public health. It was magical. One person talked about learning how social determinants of health helped them forgive their mother’s alcoholism. Another shared what it’s been like navigating a dementia diagnosis. Another described their last dinner with their mother before they left Nigeria to come to the U.S. and how that moment, plus the diagnosis that followed, shapes their career goals today. As the Executive Director of The Evidence Collective at Your Local Epidemiologist, I was ecstatic to bring this event, “Science and Storytelling,” to the community surrounding the Yale School of Public Health. Stories are not the default way most people communicate about science and public health. In fact, we are taught to take all the emotion out of data, but that makes it pretty darn boring to everyone else. And if people can’t see themselves in it, feel themselves in it, or influence it, how can we ask them to support it? Why do stories stick? How can we all—from community members to public health scientists—do better? And what are some examples?

Apr 3 • 7:02 AM EDT • Science • yourlocalepidemiologist.substack.com

How Many Minutes of Cycling a Week Improve Heart Health?

Evidence suggests even modest riding helps, but there’s a clear target if you want the biggest payoff.

Apr 2 • 3:32 PM EDT • Health • bicycling.com

RFK Jr. To Finally Face The Music For Failed Anti-Science Agenda: Public Health Project Newsletter

Over the last year plus, Trump Health Secretary RFK Jr. has seemingly been everywhere promoting his personal brand and greatest hits of evidence-free anti-science conspiracy theories – everywhere but communities...

Apr 2 • 2:42 PM EDT • Science • protectourcare.org

Mount Sinai to integrate OpenEvidence AI enterprise-wide

By embedding OpenEvidence directly into its Epic electronic health records, the New York health system aims to change how its clinicians access health data at the point of care to improve patient outcomes.

Apr 2 • 12:32 PM EDT • Health • healthcareitnews.com

CTSI TSS Webinar: 'Designing Research for the Real World: Human-Centered Design in Translational Science'

Despite strong evidence and well-designed studies, many interventions fail to translate into real-world practice. This April 15 session introduces human-centered design (HCD) as a practical, complementary approach to translational research that helps bridge this gap.

Apr 2 • 8:00 AM EDT • Science • psu.edu

From evidence to action: WHO consultation advances public health and social measures for public health emergencies

For its third global technical consultation on Public Health and Social Measures (PHSM) during health emergencies, held on 24–26 March, WHO brought together over 120 experts from 44 Member States representing ministries of health, national institutes of public health and academia as well as civil society and international organizations.

Apr 2 • 8:00 AM EDT • Health • who.int

Selwyn Rogers: Bearing Witness to Violence

Howie and Harlan are joined by trauma surgeon Selwyn Rogers, who reflects on caring for victims of gun violence and speaking with families in their darkest moments—and explains why the problem must be understood as a shared societal responsibility. Harlan examines new evidence suggesting U.S. healthcare spending has grown more slowly than expected; Howie discusses a retracted Lancet article that highlights the risks of undisclosed conflicts of interest.

Apr 1 • 8:00 PM EDT • Health • insights.som.yale.edu

Scientists Think Our Ancestors Ate Toxic Plants—And Lived to Tell The Tale

A new study from a 7,000-year-old settlement in North Macedonia reveals evidence that ancient peoples near the Mediterranean processed toxic plants for safe consumption.

Apr 1 • 2:00 PM EDT • Science • popularmechanics.com

Roger Goodell: NFL sees "no evidence" of tanking

Apr 1 • 9:34 AM EDT • Sports • sports.yahoo.com

Why Health Taxes Alone Won't Fix Malnutrition in Poor Countries

Health taxes on sugar seem to have captured the zeitgeist: Mexico's soda tax, the UK's sugar levy, South Africa's Health Promotion Levy, a sugar tax in the Philippines, and so on. The evidence on these policies suggests real benefits: (1) reduced consumption of sugary drinks, (2) measurable revenue for governments, and, (3) in theory, a nudge toward healthier choices. But the conversation is increasingly moving past sugar with increasing calls for health taxes on so-called ultra-processed foods.

Apr 1 • 8:00 AM EDT • Health • cgdev.org

'Explore, Create, Lead': The Science of a World-Class Honors Education

UConn’s Honors program is unique in the nation for its evidence-based curriculum and programming

Apr 1 • 7:30 AM EDT • Science • today.uconn.edu

Medical marijuana should not be recommended for PTSD, anxiety, or depression

“Rigorously derived evidence for the medical efficacy of marijuana is thin,” writes Kevin Sabet.

Apr 1 • 4:30 AM EDT • Science • statnews.com

New MindsEye Mission Will Reveal 'Evidence' the Game Was 'Sabotaged', Claims CEO

Build a Rocket Boy CEO Mark Gerhard says that the studio is preparing to add a new mission to its game, MindsEye, which will include "evidence" supporting his repeated claims that the game was sabotaged by bad actors.

Mar 31 • 2:48 PM EDT • Technology • ign.com

When Did the Earth's Crust Start to Shift? Scientists Uncover Evidence of Plate Tectonics Happening 3.48 Billion Years Ago

A new study provides the oldest direct evidence of tectonic plate movement ever recorded

Mar 31 • 12:48 PM EDT • Science • smithsonianmag.com

Airbnb Externship Shows 3L Isabel Samayoa How Legal Strategy Drives Business Growth  - UC Law San Francisco (Formerly UC Hastings)

An externship at Airbnb provided 3L Isabel Samayoa exposure to areas such as contracts, licensing, risk management, and growth strategy, helping her develop the skills and experience to thrive in her future career as a corporate transactions attorney. 3L student Isabel Samayoa reflects on her work with Airbnb’s in-house legal team through UC Law SF’s Corporate Counsel Externship Program. Supported Airbnb’s legal team on commercial contracts, open-source licensing, external partnerships, product counseling, and legal research. Observed how legal advice aligns with business strategy and risk management. Gained exposure to strategic decision-making while preparing for a career in corporate transactions. Q: What did you do in this corporate externship? A: I supported the Airbnb legal team across several functions, including commercial contracts, open-source licensing matters, strategic external partnerships, legal research, real estate matters, internal AI integration, and product counseling. I also gained exposure to corporate structure counseling, litigation, patent counseling, and the company’s broader business strategy. Q: What did you take away from this experience? A: One of the most valuable parts of this experience was learning how a business actually operates. I had never worked on such a large team in the private sector, so I had little exposure to how companies run internally. I learned how lawyers can provide valuable advice to support business goals, seeing how leadership evaluates risk and develops growth strategies. Understanding those priorities allows me to calibrate my legal advice to clients, balancing the client’s goals against the level of risk they are willing to take. Q: How does this experience support your career goals? A: Exploring the anatomy of a successful company was incredibly valuable because I plan to pursue a career as a corporate transactions lawyer. Being in the room with the teams discussing important decisions allowed me to see firsthand the factors that contribute to that success and how lawyers help guide those decisions. Q: Would you recommend UC Law SF and this externship? Why? A: I would absolutely recommend this opportunity. While the team worked on high-stakes matters at a highly successful company, they still created an environment where I felt welcomed. They trusted me with meaningful work and supported me every step of the way. This helped me build confidence in my analytical abilities. Q: What’s your favorite UC Law SF memory so far? A: Some of my favorite UC Law SF memories, aside from my time at Airbnb, involve mentorship. I have benefited from mentorship and have also had the chance to mentor other law students. Watching the students I mentored go on to mentor others has been particularly rewarding. I think mentorship is integral to the legal profession, and it has been inspiring to see that culture thrive at UC Law SF and continue beyond the classroom. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.

Mar 31 • 11:00 AM EDT • Business • uclawsf.edu

OpenEvidence inks deal with major health system

In this edition of STAT Health Tech: New OpenEvidence's partnership, pressure on HHS over health record sharing, and K health has a bot.

Mar 31 • 10:19 AM EDT • Health • statnews.com

Mount Sinai Health System Collaborates with OpenEvidence to Provide Evidence-Based Knowledge Within Electronic Medical Record

Collaboration extends access to all clinical users, including nurses and pharmacists

Mar 30 • 8:00 PM EDT • Health • mountsinai.org

A New Compact for Health Financing: From Principle to Practice

Centred on evidence-informed priority setting, domestic-first financing of core services, and consolidated supplementary aid, the New Compact offers a framework to guide health financing reform. This paper examines how the New Compact for health financing can be taken from principle to practice, both as a strategic guide for global reform and as a technical framework at the country-level.

Mar 30 • 8:00 PM EDT • Health • cgdev.org

Clear link discovered between chronic kidney disease and periodontal disease

Emerging evidence supports a relationship between chronic kidney disease and oral diseases, according to a recent review from University of Cincinnati College of Medicine researchers published in BMC Nephrology.

Mar 30 • 8:00 PM EDT • Health • uc.edu

Decapodiform evolutionary tree

The researchers employed multiple decapodiformes genomes along with a robust model of evolution and fossil evidence. Their evolutionary tree branches into 4 sections in the Cretaceous period, then sees no further branching until after the K-Pg extinction event, when rapid diversification occurred. Each final line end marks a different species. Of the major orders of decapodiformes, just oegopsida and spirulida remain in the deep ocean habitats of their ancestors.

Mar 30 • 5:22 AM EDT • Science • eurekalert.org

Navigating the social media minefield

Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.

Mar 29 • 8:00 PM EDT • Science • sciencebusiness.net

Navigating the social media minefield

Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.

Mar 29 • 8:00 PM EDT • Science • sciencebusiness.net

RFK Jr. makes food sound like a miracle drug, but researchers say he often overstates the science

Robert F. Kennedy Jr. has claimed diet can "cure" schizophrenia and diabetes and allow people to rid themselves of bipolar disorder. Researchers say the comments overstate current evidence.

Mar 29 • 2:26 AM EDT • Science • tucson.com

Release Engineer Completes Data Science Online Courses

This spring a release engineer completed three Coursera Data Science courses from Johns Hopkins and the Software Carpentry instructor training, each roughly four weeks long. The courses covered The Data Scientist's Toolbox, R Programming, and Getting and Cleaning Data, and required substantial external reading to finish programming assignments. The training emphasized R, GitHub, reproducible research, and evidence-based teaching methods applicable to managing distributed systems.

Mar 28 • 9:01 PM EDT • Science • letsdatascience.com

Scientists say the evidence is clear: E-cigarettes beat patches and gum in helping smokers quit

Nicotine e-cigarettes may be one of the most effective tools yet for quitting smoking, according to a sweeping review of global research. By analyzing findings from 14 major reviews spanning nearly a decade, researchers found consistent, high-quality evidence showing that nicotine vapes outperform traditional methods like patches, gum, and even behavioral support. While some lower-quality studies produced mixed results, the strongest data clearly favored nicotine e-cigarettes.

Mar 28 • 8:00 PM EDT • Science • sciencedaily.com

Scientists Found Evidence of Ice Age Humans Where It Shouldn’t Have Been

Early humans may have survived a brutal ice age by hiding out in mountain caves located in what’s now Serbia.

Mar 27 • 2:00 PM EDT • Science • popularmechanics.com

Vanderbilt Lung Transplant Program sets new record

The Vanderbilt Transplant Center is now the second largest lung transplant center in the United States by volume, with 149 lung transplants in 2025, the most ever in one year at Vanderbilt Health. The Vanderbilt Lung Transplant Program leads the nation in organ preservation and regeneration and is among the best in long-term outcomes, demonstrating the success of the interdisciplinary team in caring for these complex patients. Several features make the program unique in the United States, said Konrad Hoetzenecker, MD, PhD, professor of Thoracic Surgery and surgical director of the Vanderbilt Lung Transplant Program. Vanderbilt serves as a “second opinion center” and accepts most complex candidates that are turned down by other centers due to increased perioperative risk. This includes patients over 70 years old, patients requiring combined procedures with their transplant, multiorgan transplantations and sensitized patients (individuals who have pre-formed anti-HLA antibodies who are at higher risk for complications). The expertise and excellent outcomes have attracted patients far beyond the borders of Tennessee; almost half of Vanderbilt Health’s lung transplant recipients come from out of state. “Another unique feature is our minimally invasive transplant program,” Hoetzenecker said. “By using distinct surgical instruments and techniques, the incisions can be kept as small as 7 to 8 centimeters, which results in better healing, less pain and faster recovery. “This minimally invasive approach is embedded in an Enhanced Recovery After Surgery (ERAS) protocol, a multimodal, evidence-based perioperative care pathway designed to reduce surgical stress, minimize complications and speed up recovery. Our unique ERAS protocol, by a dedicated interdisciplinary approach, aims to improve recovery after lung transplant and reduce ICU and hospital stay.” The lung transplant program recently celebrated a milestone — 1,000 lung transplants since the program began in 1990. “This significant achievement reflects the concerted effort of a multidisciplinary collaboration by the Departments of Thoracic Surgery, Medicine, Anesthesiology and Critical Care,” said David Erasmus, MD, associate professor of Medicine and medical director of Vanderbilt Lung Transplant. Lung transplants have been attempted since the 1960s, but they were largely unsuccessful until the 1980s, when surgical techniques were refined and new antirejection drugs proved effective. Patient outcomes steadily improved from the 1990s to the present. Vanderbilt’s fourth lung transplant recipient in 1990, Pam Everett, is the longest-living, single-lung transplant known in the world, recently celebrating 35 years since her transplant. The Vanderbilt Lung Transplant surgical team is led by Hoetzenecker and Caitlin Demarest, MD, PhD, the surgical director and associate surgical director of the Vanderbilt Lung Transplant program. Erasmus is the medical director of Vanderbilt Lung Transplant along with Anil Trindade, MD, associate medical director and associate professor of Medicine.

Mar 27 • 10:12 AM EDT • Health • news.vumc.org

No One UI 8.5 in April? Galaxy S25 update roadmap takes unexpected turn

It turns out that Samsung has no plans to roll out the Galaxy S25 family’s One UI 8.5 update in April. This isn’t an official confirmation or a leak, but a fact supported by evidence, suggesting a delay in the major update rollout. Samsung enthusiast Alfaturk discovered a potential April 2026 security update for the […]

Mar 27 • 8:28 AM EDT • Technology • sammyfans.com

Scientists stunned as Mars dust storms blast water into space

Mars may look like a frozen desert today, but new evidence suggests its watery past didn’t simply fade away quietly—it may have been blasted into space by powerful dust storms. Scientists have discovered that even relatively small, localized storms can hurl water vapor high into the atmosphere, where it breaks apart and escapes.

Mar 26 • 8:00 PM EDT • Science • sciencedaily.com

Scientists Filmed a Whale Birth. The Surprise: Mom Had Many Helpers.

The episode, involving a group of sperm whales, adds to evidence that humans aren’t the only species that gets some form of assistance during and after delivery.

Mar 26 • 2:00 PM EDT • Science • nytimes.com

NASA’s Hubble Detects First-Ever Spin Reversal of Tiny Comet

Astronomers using Hubble found evidence that the spinning of a comet 41P slowed and then reversed its direction of rotation.

Mar 26 • 10:00 AM EDT • Science • science.nasa.gov

New studies of old dogs help scientists understand where they came from

Using the oldest dog genes studied so far, scientists are finding more evidence that our furry friends have been our companions for thousands of years. Scientists think dogs descended from an ancient...

Mar 25 • 12:00 PM EDT • Science • yahoo.com

Humans Had Dogs Before They Had Farming, Ancient DNA Confirms

New research pushes the first genetic evidence of dogs back by 5,000 years and suggests that hunter-gatherer groups may have acquired dogs from one another.

Mar 25 • 12:00 PM EDT • Science • nytimes.com

Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com

Crystal Etienne: Florida’s school choice debate isn’t ignoring evidence, it’s asking for it

Critics argue school choice expansion lacks full data and accountability

Mar 24 • 6:31 PM EDT • Politics • floridapolitics.com

Scientists found a rhino in the Arctic and it changes everything

Scientists have uncovered a new species of rhinoceros in the Canadian High Arctic, revealing that rhinos once lived far farther north than expected. The fossil, dating back 23 million years, is unusually complete and has helped reshape ideas about how these animals migrated between continents. Evidence suggests rhinos crossed from Europe to North America more recently than scientists once thought.

Mar 23 • 8:00 PM EDT • Science • sciencedaily.com

'Sled head': Lawsuits against USA Bobsled/Skeleton allege brain injury

Three personal injury lawsuits have been filed on behalf of elite bobsledders who claim officials intentionally concealed evidence that the sport causes brain injuries.

Mar 23 • 4:31 PM EDT • Sports • latimes.com

New York approves cannabis for anxiety. Science says it may not help

A Lancet Psychiatry study found no evidence cannabinoids treat anxiety, PTSD. In NY, any practitioner can certify a patient for medical cannabis for any condition they deem appropriate.

Mar 23 • 6:00 AM EDT • Science • timesunion.com

Scientists See Converging Evidence of Antarctic Ice Retreat

A sediment core spanning millions of years and new modeling studies point to significant ice retreat under temperatures similar to today.

Mar 23 • 4:50 AM EDT • Science • insideclimatenews.org

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com

Webb Telescope spots “impossible” atmosphere on ancient super Earth

Astronomers have uncovered surprising evidence of a thick atmosphere surrounding TOI-561 b, a scorching, fast-orbiting rocky planet once thought too extreme to hold onto any gas. Using NASA’s James Webb Space Telescope, researchers found the planet is far cooler than expected for a bare rock, hinting at a heat-distributing atmosphere above a churning magma ocean. This strange world—where a year lasts just over 10 hours and one side is locked in eternal daylight—may even be rich in volatile materials, behaving like a “wet lava ball.”

Mar 21 • 8:00 PM EDT • Science • sciencedaily.com

Tectonic shift: Earth was already moving 3.5 billion years ago

Scientists have uncovered the oldest direct evidence yet that Earth’s tectonic plates were on the move 3.5 billion years ago. By analyzing magnetic fingerprints in ancient rocks, they reconstructed how parts of the planet slowly drifted and even rotated over time. This challenges long-standing ideas that early Earth may have had a rigid, unmoving surface. Instead, it suggests the planet was already dynamic—and possibly setting the stage for life—much earlier than expected.

Mar 20 • 8:00 PM EDT • Science • sciencedaily.com

Opinion | There’s No Judicial Climate Science Scandal

My co-writer and I didn’t commit academic misconduct in our chapter for a federal evidence manual.

Mar 20 • 11:42 AM EDT • Science • wsj.com

Evaluating the science behind nutrition

Evidence Center director touts multidisciplinary focus for new discoveries at national food policy conference.

Mar 20 • 9:05 AM EDT • Science • agrilifetoday.tamu.edu

Healthcare employee health plan bridges the gap between data and action

Integrating UpToDate evidence-based clinical decision support helps health plan optimize costs and member-centered care.

Mar 19 • 8:00 PM EDT • Health • wolterskluwer.com

A new study questions when people first reached South America

Data suggest people lived at Chile’s Monte Verde site thousands of years later than thought, challenging key “pre-Clovis” evidence. Not all agree.

Mar 19 • 2:00 PM EDT • Science • sciencenews.org

Earth’s continental plates were moving 3.48 billion years ago

Magnetic crystals provide the earliest evidence yet of the plate tectonics that likely made Earth habitable, pushing its start back by 140 million years.

Mar 19 • 2:00 PM EDT • Science • sciencenews.org

Lebanon: Israel must halt attacks on healthcare workers, medical facilities and first responders

Responding to the killings and injuries of dozens of healthcare workers and first responders in Lebanon since 2 March 2026, amid escalating attacks by the Israeli military and its allegations – without providing evidence – that ambulances and healthcare sites are being used for military activities and may be targeted, Kristine Beckerle, Deputy Regional Director for the Middle East and North Africa at Amnesty International, said: “Israel is deploying the same deadly playbook it used in 2024 in Lebanon to kill dozens […]

Mar 19 • 7:09 AM EDT • Health • amnesty.org

How worried should you be about ultra-processed foods?

We are constantly told to watch out for the health risks of eating ultra-processed food, but should you be worried every time you sit down for a meal? Sam Wong takes a look at the evidence

Mar 19 • 4:00 AM EDT • Health • newscientist.com

Study Finds Little Proof Cannabis Helps Most Mental Health Conditions

By HealthDay Staff HealthDay ReporterWEDNESDAY, March 18, 2026 (HealthDay News) — Cannabis-based medications are often used to treat mental health problems, but a new review suggests they may not work as well as many people hope. Researchers looked at decades of studies and found little evidence ...

Mar 18 • 9:05 AM EDT • Health • usnews.com

Earth Is Missing a Billion Years of History. We Finally Know Why

We thought global ice erased a billion years of history but new evidence points to ancient supercontinents.

Mar 18 • 7:15 AM EDT • Science • zmescience.com

Large Medical Cannabis Review Finds Scarce Evidence It Treats Mental Health Disorders

We know so very little.

Mar 18 • 7:00 AM EDT • Health • sciencealert.com

Why Some Birds Seem to Be Developing a Cigarette Habit

Research from Poland adds to evidence from Latin American countries that compounds in used cigarette butts ward off parasites in bird nests.

Mar 18 • 5:03 AM EDT • Science • nytimes.com

Deputy AG Blanche defends DOJ’s work on Epstein case ahead of closed-door Hill briefing

Deputy Attorney General Todd Blanche, ahead of his appearance on Capitol Hill Wednesday, defended the Justice Department’s handling of the Epstein files and asserted it does not have new evidence to prosecute anyone for crimes related to Jeffrey Epstein, in an interview released Tuesday that forced him to face theories plaguing the department.

Mar 18 • 12:56 AM EDT • Politics • cnn.com

Using marijuana to ease anxiety or depression? Science shows the evidence isn’t there

Marijuana doesn’t help with anxiety, PTSD, depression or other mental health conditions, according to two large, new studies.

Mar 16 • 7:30 PM EDT • Health • cnn.com

Cannabis is not an effective treatment for common mental health conditions, says review

International researchers find ‘very little evidence’ medical form of the drug can treat anxiety, anorexia and other disorders

Mar 16 • 7:30 PM EDT • Health • theguardian.com

Scientists Find First Evidence of "Evolutionary Rescue" In The Wild

Meet the wildflower that evolved its way out of a historic drought.

Mar 16 • 7:04 AM EDT • Science • iflscience.com

Report: The Wolf Among Us Current-Gen Port Is in the Works

New evidence suggests a remaster or port of the original The Wolf Among Us could be in development, as we tie it to a recent report.

Mar 15 • 4:19 PM EDT • Technology • mp1st.com

Dozens of Medical Workers Killed as Israel Hits Lebanon

Lebanese health officials say that 31 health workers have been killed by Israeli strikes. Israel claimed, without evidence, that Hezbollah has been using ambulances and medical facilities.

Mar 14 • 2:14 PM EDT • Health • nytimes.com

Is the ACA driving up healthcare costs? The evidence is mixed

What to know in the debate surrounding the role of the Affordable Care Act in driving up medical costs.

Mar 14 • 6:00 AM EDT • Health • latimes.com

Judge quashes Justice Department subpoena of Federal Reserve

Judge James Boasberg said that a "mountain of evidence suggests" that the purpose of the subpoenas was simply to pressure the Fed to cut its key interest rate

Mar 13 • 3:41 PM EDT • Politics • spectrumlocalnews.com