SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " tia " 11,046 found 🔀 AI-powered Shuffle
Jacobs Entertainment begins construction on downtown sports fields
Jacobs Entertainment has begun building the flat fields that will make up their youth sports initiative.
Age Comes for Us All—Even Politicians
Don’t look now, but the period from now through the 2028 presidential election will be a historic inflection point in our politics. We’ll see enormous generational change take place amid enormous uncertainty and volatility.
Apple Business Essentials goes free as Apple merges enterprise tools into Apple Business
Apple is offering Apple Business Essentials for free as it merges device management, branding tools, and support under the new Apple Business platform.
Paranovus Entertainment Technology (PAVS) surges 125.9% as low-float dynamics amplify trading volatility
Paranovus Entertainment Technology Ltd. (PAVS) is up 125.9% today. Here is some analysis on what might have caused this price movement.Analysis: The most likely driver looks technical rather than fundamental: PAVS has been prone to sharp, liquidity-driven swings after its recent reverse split reduced share count and tightened the tradable float. This could also be because traders are positioning around potential changes in the company’s at-the-ma
Meet the 2026 Influential Women in Business and see the Women’s Leadership Symposium lineup
They run hospitals, build companies, fight cancer and welcome visitors to the Capital Region. Now, nine of the area’s most accomplished women are being recognized as 2026 Influential Women in Business by Baton Rouge Business Report. The honorees will be recognized May 19 at the Influential Women in Business Luncheon, which follows the fourth annual […]
World TB Day: Scaling workplace healthcare interventions
Four lessons from the End Workplace TB initiative could help other private sector-led campaign coalitions to scale their workplace healthcare programmes.
G7 Entertainment Marketing Launches Wild by G7 to Help Destinations Turn Culture Into Travel Demand
New Venture Responds to Surging Demand for Experience-Driven Travel by Helping Destinations Create Cultural Moments that Drive Visitation, Economic Impact, and Brand Loyalty Wild by G7 is producing the Rendezvous Music Festival The Head and the Heart band performed at a past Rendezvous Music Festival in Jackson, Wyoming Wild by G7 Sizzle NASHVILLE, Tenn. and JACKSON, Wyo., March 24, 2026 (GLOBE NEWSWIRE) -- G7 Entertainment Marketing, the experiential and talent booking agency behind campaigns f
Stony Brook Southampton Educators Earn Suffolk County Recognition for Science, Sustainability and Service
Suffolk County Legislator Ann E. Welker recognized educators from Stony Brook Southampton during the March 10 general meeting of the Suffolk County Legislature and the Women of Distinction luncheon, both held in Riverhead, NY. Wendy Pearson, vice president for strategic initiatives at Stony Brook University and executive director for Stony Brook Southampton, received a 2026 Woman
Scientists Must Speak Clearly, Especially in Court: Five Tips for Clear Communication
As climate impacts intensify, so does the legal push to hold polluters accountable, protect vulnerable communities, and enforce environmental laws. And in these legal cases, science is key. Because science can’t present itself on the stand, scientists are essential to give scientific results a voice
‘Healthy Rounds’: Dealing With Dementia
Dr. Kristina Zdanys, geriatric psychiatrist in the UConn Center on Aging, joins Dr. Anthony Alessi’s podcast
The Best Time To Take Vitamin D for Brain Health and Mood
Vitamin D is essential for brain health and mood. Taking it in the afternoon with a large meal can help improve absorption and effectiveness.
Steven Corcelli named William K. Warren Foundation Dean of the College of Science
Steven A. Corcelli, professor of chemistry and biochemistry at the University of Notre Dame, has been appointed the William K. Warren Foundation Dean of the College of Science by University President Rev. Robert A. Dowd, C.S.C., effective April 1. Corcelli, who has served as interim science dean since July, was selected through a comprehensive national search launched after his predecessor, Santiago Schnell, was appointed as Dartmouth’s provost.
Timeline: A Milwaukee father's fight for his son's mental health treatment
Pete Christiansen spent eight months trying to get Milwaukee authorities to commit his son for mental health treatment, also known as Chapter 51.
Crowded Democratic Race for California Governor Could Open Door for Republicans
By Joseph Ax and Costas Pitas March 24 (Reuters) - By many measures, California is the center of the Democratic Party's political universe. The most populous U.S. state, it is home to both the party's last presidential nominee, Kamala Harris, and possibly its future one, Governor Gavin Newsom. But ...
What’s That Building? South portico of the Griffin Museum of Science and Industry
The structure’s south entrance will be put to use for the first time in more than a century, just in time for the Obama Presidential Center opening nearby this summer.
Why REI treats CX as a critical business function
The outdoor retailer is focused on doubling down on its differentiators, REI’s Clay Walton-House said. That means investing in its elevated services and member experience.
2026 ‘Dirty Dozen’ produce: Nearly 100% tested positive for pesticides, including ‘forever chemicals’
The 2026 “Dirty Dozen” list of most contaminated produce has a worrisome finding. Many of the most common pesticides are also potentially toxic “forever chemicals.”
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Corona Santiago hands Corona its first baseball defeat behind Troy Randall
Corona Santiago baseball takes the first game of three-game series over Corona with a 6-2 victory.
Hochul pushes environmental review reforms amid state budget negotiations
Hochul has touted the policy as a key element of her affordability agenda.
Scientists say NAD+ could slow aging and fight Alzheimer’s and Parkinson’s
A global team of leading scientists is zeroing in on a tiny but powerful molecule that could reshape how we age. Known as NAD⁺, it plays a crucial role in keeping our cells energized, repairing DNA, and maintaining overall health—but its levels steadily decline over time, potentially fueling diseases like Alzheimer’s and Parkinson’s. Researchers are now exploring ways to boost NAD⁺ using compounds like NR and NMN, with early studies hinting at improvements in memory, metabolism, and physical function.
Trump Delays Threat to Iran, but War Negotiations Are in Early Stage
President Trump postponed his threat to strike power plants in Iran, citing “productive conversations” with the Iranians. But officials said the talks were in an early stage and not substantive.
Astrophysicist Deborah Haarsma Connects Science with Christian Faith at Pepperdine Libraries' Frank Pack Lecture
Hosted by Pepperdine Libraries' Rushford Center, the University community was given the special honor of hearing Haarsma's insights on Christian faith and science at the 21st annual Frank Pack Distinguished Christian Scholar Lecture.
The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi
Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat
Two bills with the potential to increase healthcare competition in Tennessee make headway
Two bills making their way through the Tennessee General Assembly have the potential of shifting the healthcare landscape of our region.
Two bills with the potential to increase healthcare competition in region make headway
Two bills making their way through the Tennessee General Assembly have the potential of shifting the healthcare landscape of our region.
Marco Rubio's evolution. Hardliner becomes Trump’s top Cuba negotiator
From hardliner to dealmaker, Marco Rubio evolves on Cuba, taking charge of Trump’s talks with Havana.
Rahm Emanuel says federal workers shouldn't bet on politics
Former Obama chief of staff and possible 2028 presidential candidate Rahm Emanuel is calling for a federal employee ban on prediction markets betting.
Science Through Shadows: How Astronomical Alignments Reveal the Universe
When one celestial object passes in front of another, it can cast a shadow that travels across space – and sometimes across Earth. These moments of alignment, known as eclipses, occultations, and transits, allow scientists to study distant objects in remarkable ways. By observing how light changes when an object briefly blocks another, astronomers can measure sizes and shapes, detect atmospheres, and refine the orbits of asteroids and planets.
Nvidia CEO Says He Hates AI Slop Too After DLSS 5 Panic
Jensen Huang tried again to defend one of the company's most unpopular initiatives
Trump says talks are happening. Iran says they’re not. Why a former Trump Iran negotiator says both might be true
WATCH LIVE: Trump joins Memphis Safe Task Force roundtable, initiative aimed at combating crime
Intel Core Ultra 5 250K Plus Review - Disrupting AMD's Entry-Level
Intel is breathing new life into its Arrow Lake lineup with the Core Ultra 5 250K Plus. Priced at an attractive $200, this little powerhouse outperforms most AMD CPUs in applications and delivers competitive gaming performance, too. It's a strong contender for budget-friendly builds, and overclocking potential is good, too.
Trump was offered an off-ramp to the DHS shutdown but he didn’t take it
President Donald Trump was presented Sunday with a potential off-ramp to the more than month-long Department of Homeland Security shutdown: fund every part of the department except enforcement operations by Immigration and Customs Enforcement, two sources familiar with the conversations told CNN.
Kyle Shanahan shares his expectations for 49ers' Trent Williams contract impasse
San Francisco 49ers coach Kyle Shanahan told NBC Sports Bay Area that he's staying out of the team's contract negotiations with Trent Williams.
Why Kyle Shanahan believes Mike Evans, Christian Kirk picked 49ers over others
Veteran wide receivers Mike Evans and Christian Kirk could have made more money elsewhere, but there was a common reason why they picked the 49ers.
Exit polls suggest Italy's Meloni has narrowly lost justice referendum vote
Exit polls on Monday suggested Italian Prime Minister Giorgia Meloni had narrowly lost a referendum on her flagship reform of the judicial system, dealing a potential blow to the ruling coalition ahead of next year's general election.
Welcome, American scientists: Europe, a haven for researchers struggling under Trump
Initiatives are multiplying in EU countries including France, Germany and Austria to attract the talent being driven away by the US president’s policies
The problem with Trump promoting "gold standard science"
This simplistic branding is confusing, misleading, and potentially harmful to scientific literacy.
The New Party Politics of Abortion
Some Republicans remain consistently pro-life. But under Trump’s lead, the GOP has become an anti-Roe yet pro-choice coalition.
As mayoral election looms, D.C.’s business class worries about what’s next
A potential leftward shift in the wake of the pandemic and the Trump administration’s cutting of thousands of federal jobs has sparked unease in the city’s business community.
Costco Expands Member Offerings With Fertility Care And In Store Events
Costco Wholesale has partnered with Sesame and IVI RMA North America to offer U.S. members access to advanced fertility care with exclusive pricing and coordinated services. The retailer is also rolling out a national outdoor cooking roadshow in warehouses, featuring multiple brands and on site experiences for members. These moves extend Costco’s reach further into healthcare services and experiential retail beyond its traditional bulk merchandise model. For investors tracking...
The Christian Science Monitor Daily for March 23, 2026
Rethink the news: Reducing news to hard lines and side-taking leaves a lot of the story untold. Progress comes from challenging what we hear and considering different views.
Executive Council seeks greater role in half-billion-dollar rural health initiative
New Hampshire executive councilors are seeking a greater role in a $640 million rural health initiative after initially delaying approval and securing more oversight.
Scientists Trap Light in a Layer 1,000x Thinner Than a Hair
Scientists have found a way to trap light in an extremely thin layer, potentially reshaping how future photonic devices are built.
Extendend interview: Dr Roham Alvandi on Iran, Britain, and the futures that might have been
From Cold War power games to the cultural aspirations of the Pahlavi era, this extended conversation pulls back the curtain on the global forces that continue to shape - and be shaped by - Iran today. Dr Roham Alvandi is Director of the Iranian History Initiative at the London School of Economics and Political Science.
Apple already has the perfect platform for deploying conversational AI
When Apple initially rolled out Apple Intelligence, the company was pretty openly against the idea of creating a Siri chatbot....
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.
France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.
The FBI Just Issued A Warning About A Hidden Threat In Your Home Wi-Fi Network
The FBI is warning that criminals may hijack your home Wi-Fi through residential proxies, using your IP address to hide illegal online activity.
Educational Service Center awarded Teach Computer Science 2.0 Grant
The Educational Service Center of the Western Reserve has been awarded $584,614 through the Ohio Teach Computer Science 2.0 State Grant, a competitive initiative funded by the Ohio Department of Higher Education. As part of an $8 million…
Nasal swab may catch Alzheimer's disease earlier — here's how it works
Michael McCarthy Considering Three Races As Options For Journalism's Return
After Journalism worked five furlongs in company Sunday at Santa Anita, trainer Michael McCarthy said he is looking at three potential races to kick off the colt’s 4-year-old campaign. Journalism could return in either the Oaklawn Handicap (G2) or Ben Ali (G3) at Keeneland, both on April 18, or ...
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Sebastian Kehl exits role as Borussia Dortmund sporting director
Borussia Dortmund sporting director Sebastian Kehl is leaving the team with immediate effect as the club undergoes a major shakeup after what will be a trophyless season.
'Everybody Loses' author discusses the meteoric rise of sports gambling
Two years ago, Americans bet $120 billion on sports, a 27% increase from the previous year. That figure grew to $150 billion in 2024. Journalist Danny Funt investigates what's considered one of the most consequential — and least scrutinized — shifts in modern American sports in his new book, "Everybody Loses: The Tumultuous Rise of American Sports Gambling."
German club Borussia Dortmund parts ways with sports director Kehl
German football club Borussia Dortmund said on Sunday it is ending its collaboration with sports director Sebastian Kehl with immediate effect.
Girls' basketball coach of the year: Alicia Komaki of Sierra Canyon
She came up with a winning formula to defeat Etiwanda and No. 1 Ontario Christian in the Southern Section Open Division championship.
Southland girls' basketball final rankings for 2025-26 seaosn
A look at the top 20 high school girls' basketball teams in the Southland, led by Open Division state champion Ontario Christian.
Umberto Bossi, the League's populist founder and a pivotal figure in Italian politics, dies at 84
ROME — Umberto Bossi, the founder of Italy’s populist Northern League and one of the most influential — and polarizing — figures...
How “Feeling Over Facts” Reshaped American Politics—from Gingrich to Trump
There was a moment in the 2016 presidential campaign that, in retrospect, sounds less like campaign chatter than something a post-modern French philosopher might have slipped into American politics.
Are pretzels a healthy snack? Here's what dietitians say
Pretzels are a classic snack food, but are they good for you? Dietitians break down the nutrition content of pretzels and share the healthiest types.
Elon Musk uveils moonshot Terafab project. Here are 4 takeaways.
Elon Musk said his Terafab project, a joint Tesla and SpaceX chip manufacturing initiative, will be needed to unlock a terawatt of AI computing power.
Tottenham Hotspur have chance to turn relegation narrative around against Nottingham Forest
Both sides are barely hovering above the relegation zone, Spurs boasting one point over 18th-place West Ham while Nottingham are only above the drop zone on goal differential
Beshear Criticizes Vance in Ohio, Stoking 2028 Presidential Tensions
Mr. Beshear, the Democratic governor of Kentucky, sharply criticized Mr. Vance as both angle for potential presidential runs.
Business investment in the era of digital transformation
The weak performance of business investment across the OECD since the Global Financial Crisis holds back potential growth. However, it masks a strong investment dynamic in digital assets such as hardware, software, and databases. This column describes how this divergence between digital and non-digital assets has intensified from the mid-2010s. The strong investment performance of the US relative to the rest of the OECD is almost exclusively a digital phenomenon. A ‘digital divide’ is emerging, where laggard countries are accumulating digital capital per worker more slowly than those with higher initial starting levels.
Uber's Advertising Business May Be Bigger Than Investors Think
Uber is best known for moving people and delivering food. However, something small but potentially profitable is growing at the company.
Senate blocks amendment on transgender athletes during weekend session
The amendment that was blocked by a 49-41 vote would create potential penalties for educational institutions that receive federal funding
Trump threatens to deploy ICE agents to airports Monday if funding deal isn’t reached
President Donald Trump said Saturday he will deploy Immigration and Customs Enforcement agents to US airports on Monday if an agreement isn’t reached to fund the Department of Homeland Security amid a partial government shutdown.
Meet Delaware's 2025 Most Influential People in Arts and Entertainment
Meet Delaware's 2025 Most Influential People in Arts and Entertainment
iPhone 18 Pro camera may come with pro software, Apple considered buying Halide
Two months ago, Halide cofounder and designer Sebastiaan de With made a surprise announcement that he was joining Apple’s design...
Apple TV Is Now Almost 20 Years Old
The Apple TV is now almost two decades old amid rumors of the announcement of a new model. Today marks 19 years Apple launched the original Apple TV. Apple CEO Steve Jobs unveiled the Apple TV at Macworld Expo in January 2007 alongside the original iPhone, but it didn't launch until March. The Apple TV was initially previewed as the "iTV". The device allowed users to wirelessly stream movies, TV shows, music, and photos from their Mac or PC directly to their TV.
MAGA says the SAVE America Act is crucial. A new poll shows Americans don’t agree
To hear some prominent MAGA voices tell it, the marathon Senate debate over the “SAVE America Act” is an existential one for the Republican Party. But the urgency to pass the legislation is not felt by Americans more widely.
Why are humans the only species with a chin?
Potential explanations abound, yet recent research has shed new light on the question.
With casino empire gone, Trump family bets on prediction markets
With his Atlantic City casinos in duress in the 1990s, Donald Trump saw a potential lifeline in sports betting and aggressively campaigned to legalize it in New Jersey. But when state powerbrokers shut him down, Trump vowed that he’d eventually find a way to win.
Is Britain ready for US-style religious politics?
Fuelled by new funding and transatlantic links, Christian groups are playing an increasingly prominent role on the UK right
Kaiser Health Care unions ratify new contracts
LOS ANGELES, Cali. (KESQ) — After months of negations, including multiple strikes, UNAC/UHCP health care professionals have voted to ratify new contracts with Kaiser Permanente. During this negotiation period, union members walked off the job in January in what became the longest open-ended strike by nurses and health care professionals in U.S. history, lasting nearly
Exclusive | Growing Frustration With Chuck Schumer Spurs Talk of Replacing Him
Some Democrats on Capitol Hill are discussing how to get New York’s senior senator to step aside as minority leader amid concerns about his negotiating style and midterms strategy.
There Aren't a Lot of Reasons to Get Excited About a New Amazon Smartphone
The company is reportedly building a new AI-powered mobile device. If Amazon follows through on the plan, experts warn it would be next to impossible to break into a crowded market.
Nuclear reactor developer X‑energy files for US IPO
X-energy has filed for an initial public offering in the United States, it said on Friday, as the reactor developer aims to tap growing investor enthusiasm for nuclear power.
Exclusive: Dimer Health raises $13.5M for patient discharge
The round gives Dimer approximately three years of runway, though it will begin having initial conversations about its next round soon.
Swalwell plays up athletic credentials in effort to blunt DHS sweeps at World Cup
Rep. Eric Swalwell, citing his Division I soccer past, introduced a bill to ban ICE enforcement on public transit near World Cup sites this summer.
Are Pretzels Healthy? Dietitians Explain the Pros and Cons
Pretzels are a classic snack food, but are they good for you? Dietitians break down the nutrition content of pretzels and share the healthiest types.
Hegseth Invokes Divine Purpose to Justify Military Might
Defense Secretary Pete Hegseth has imbued U.S. military actions with a Christian moral underpinning that suggests they are divinely sanctioned.
Why Wall Street is scouting college sports stars
Banks have realised the potential from tapping in to tomorrow’s elite - and by definition wealthy - athletes
US furiously seeks to avert potential months-long closure of Strait of Hormuz
US officials are furiously trying to avert a potential months-long closure of the Strait of Hormuz, privately acknowledging that reopening the key waterway is a problem without a clear solution and dependent at least in part on what lengths President Donald Trump is willing to go to force the Iranian regime’s hand, multiple administration and intelligence officials tell CNN.
NVIDIA DLSS 5 Takes 2D Frame and Motion Vectors as Input
The public is still learning more about DLSS 5 technology, and NVIDIA is gradually revealing additional details. In a conversation between YouTuber Daniel Owen and NVIDIA's GeForce Evangelist Jacob Freeman, we discover that DLSS 5 essentially takes 2D frames and motion vectors as input, applying its...
Cristiano Ronaldo misses out on Portugal friendly vs. USMNT and Mexico due to injury
The matches are in the last internatinoal window before this summer's World Cup
Chuck Norris, 'Walker, Texas Ranger' star and martial artist, dies at 86
The "Walker, Texas Ranger" star reportedly had an undisclosed medical emergency on the island of Kauai.
Pete Hegseth's Christian rhetoric reignites scrutiny after the U.S. goes to war with Iran
Hegseth has pushed policy changes that reflect his Christian views, including a revamp of the military chaplain corps.
Long lines persist at area airports as partial government shutdown continues
350 TSA agents have quit since the current shutdown began, according to DHS.
Chuck Norris, martial arts master and actor, dies at 86
His family announced his death Friday
Chuck Norris, action hero and ‘Walker, Texas Ranger’ star, has died
Chuck Norris, veteran, martial arts world champion, action hero and early 2000s Internet meme inspiration, whose rugged demeanor was immortalized on hit show “Walker, Texas Ranger,” has died.
Chuck Norris, martial arts master and actor, dies at 86
His family announced his death Friday
Tilman Fertitta Bid Puts Caesars Entertainment Value And Future In Focus
Tilman Fertitta is reportedly in advanced talks to acquire Caesars Entertainment, ahead of a rival bid from investor Carl Icahn. The potential deal would combine Fertitta's Golden Nugget casino interests and sports assets with Caesars Entertainment's Las Vegas Strip footprint. This development is attracting attention from shareholders as a possible turning point for NasdaqGS:CZR. Caesars Entertainment, trading as NasdaqGS:CZR, last closed at $27.44. The share price return is up 44.8% over...
Michigan confirms measles outbreak in Washtenaw County: What to know
An initial case was identified in an unvaccinated adult who visited sites in Ypsilanti and Canton earlier this month. Since then, two more related cases have been reported.
Regularly Playing This 1 Online Game May Reduce Dementia Risk by 25%
In TODAY.com's Expert Tip of The Day, a neurologist explains how playing games that build cognitive speed can protect against dementia for decades.
SAP CEO Says Defense Industry Sales Are Fastest Growing Business
SAP SE Chief Executive Officer Christian Klein said the defense industry has become the company’s fastest growing business line as military budgets soar around the world.
3 Democratic pastors in Iowa are running for Congress, a snapshot of a national trend
More Democrats are openly running on faith, as progressive clergy and other religious candidates push back on the idea that Christianity belongs to the right
Umberto Bossi, the League's populist founder and a pivotal figure in Italian politics, dies aged 84
Umberto Bossi, the firebrand founder of Italy’s populist Northern League and one of the most influential — and polarizing — figures of Italian politics, has died, his party said