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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
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They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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Google is ramping up development of a dedicated Gemini AI app for Apple Inc.’s Mac computer lineup, looking to step up competition with OpenAI and Anthropic PBC.
Even humans love a good mating call
Volunteers listened to animal mating calls and played a computer game—for science.
'In Good Health': Why Is Colorectal Cancer Affecting Generations Differently?
Cases of colorectal cancer in young people have risen nearly 60 percent since the early 2000s. That’s according to data from the Centers for Disease Control and the National Cancer Institute. And a new study out this month by the American Cancer Society found that colorectal cancer is now the deadliest kind for those younger than 50.But this rise isn’t being felt across all generations in the same way. People born around 1990 are four times more likely to develop rectal cancer than those born around 1950. And for those 65 and older, colorectal cancer rates have actually decreased.So, what’s going on? And what can you do to protect yourself and your gut health? For those answers and more, we turn to a panel of experts.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
I’ve been using the Nothing Phone (4a) Pro for a week, and it’s absolutely brilliant
Since its announcement earlier this month, I’ve been pretty excited for the Nothing Phone (4a) Pro’s debut and, after using...
German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
Labor unions' influence in LA mayor's race is harder to predict this year
As Mayor Karen Bass vies to keep her seat, she has a liberal opponent and a more complicated relationship with some labor leaders.
UK health official says too soon to declare Kent meningitis outbreak contained
A British health official said on Thursday it was too soon to declare that a meningitis outbreak in southeast England has been contained, as authorities reported seven new cases of the disease that has killed two people so far.
Watch: Affordability Plagues Health Care in Its Shift From Nonprofit to Profit Machine
On “What the Health? From KFF Health News,” distributed by WAMU, chief Washington correspondent and host Julie Rovner sat down with Drew Altman, president and CEO of KFF, to talk about the likelihood of a national health care debate.
This Google Maps update could change how you share your location
The new method is simpler and more obvious.
HSBC mulls job cuts that could impact around 20,000 roles, Bloomberg News reports
HSBC Holdings Plc is weighing a wave of deep job cuts over the coming years that could ultimately impact around 20,000 roles, or about 10% of its total workforce, Bloomberg News reported on Wednesday, citing people familiar with the matter.
Integrating health equity into energy transitions and climate governance
Nature Medicine - The health benefits of clean energy transitions are unevenly distributed, even when emissions targets are met. A health-centered global governance framework is urgently needed to...
Pre-litigation meeting fails to resolve dispute between businesses and Black Mountain
An update now on a story we’ve been following for you, the ongoing dispute between Black Mountain Brewing and the Town of Black Mountain.
Georgia was going to dump voting machines that Trump hates. But then things got complicated
A Georgia effort to dump voting machines that Donald Trump hates may get derailed by fear of a chaotic last-minute shift in election methods.
Unilever, Kraft Heinz held talks to merge food business and condiments division, FT reports
Unilever and Kraft Heinz held talks to merge Unilever's food business and Kraft Heinz's condiments division, the Financial Times reported on Wednesday, citing people familiar with the talks.
Unilever shares fall on investor concerns about food business spin-off
Unilever shares fell 3.5% on Wednesday with investors concerned that the maker of Hellmann's sauces would get "distracted" by the potential spin-off of its food business, questioning the benefits so soon after its protracted ice cream unit split.
Federal investment fuels new labs for coastal science and restoration
The two are part of the Institute of Environment’s efforts to expand research on the Everglades, Biscayne Bay and other South Florida’s coastal ecosystems. The project received $11.5 million in funds.
Researchers uncover iPhone spyware capable of penetrating millions of devices
A powerful software exploit capable of penetrating and stealing information from potentially hundreds of millions of Apple iPhones was planted on dozens of websites in Ukraine in recent weeks, researchers said on Wednesday.
GOP candidate cites ‘failure’ of Newsom, Dems as new poll shows Republicans leading crowded California field
Steve Hilton, a Republican running for governor, said that the “absolute failure" by California Gov. Gavin Newsom and Democrats means that the GOP has a real shot at victory this year.
EU Inc proposal seeks to rival US in innovation by easing startup creation
The European Commission proposed on Wednesday allowing firms to set up in as little as 48 hours and operate according to a single set of rules across the 27-nation EU in a bid to narrow the gap with the United States in innovative startups.
Does Tencent Music Entertainment (TME)ʼs New Dividend Signal Evolving Capital Priorities or Strategic Caution?
Tencent Music Entertainment Group has reported fourth-quarter 2025 revenue of CNY 8,641 million and net income of CNY 2,203 million, and for the full year 2025 revenue of CNY 32,902 million and net income of CNY 11,056 million, alongside declaring an ordinary annual cash dividend of US$0.12 per share or US$0.24 per ADS totaling about US$368 million. Beyond the headline growth in revenue and earnings, the decision to distribute a sizeable cash dividend highlights Tencent Music Entertainment’s...
Child vaccination rate drops sharply in Michigan under RFK Jr's influence
Vaccination rates among young children in Michigan dropped sharply during the first year of the Trump administration, a Reuters analysis of state data shows, providing an early indication of how vaccine-skeptic Health Secretary Robert F. Kennedy Jr. is influencing immunization practices in the United States.
Mental health staff accept pay offer to end strikes
Workers will get a one-off payment but no extra pay rise after the months-long dispute.
Inside JB Pritzker’s power play in Illinois’ Senate primary – and what it means for a 2028 run
Many assume JB Pritzker’s run for president is just a year away. His effort to engineer a victory for his lieutenant governor, Juliana Stratton, in Illinois’ Senate primary was also a victory for him and a political operation with national ambitions.
Deputy AG Blanche defends DOJ’s work on Epstein case ahead of closed-door Hill briefing
Deputy Attorney General Todd Blanche, ahead of his appearance on Capitol Hill Wednesday, defended the Justice Department’s handling of the Epstein files and asserted it does not have new evidence to prosecute anyone for crimes related to Jeffrey Epstein, in an interview released Tuesday that forced him to face theories plaguing the department.
Gilgeous-Alexander scores 40 as Thunder clinch playoff berth
Shai Gilgeous-Alexander delivered a 40-point scoring performance as the Oklahoma City Thunder became the first team to punch their ticket to the NBA playoffs with a 113-108 defeat of the Orlando Magic on Tuesday.Reigning NBA Most Valuable Player Gilgeous-Alexander saluted the Thunder's resilience after a mixed first-half performance.
Stratton Wins Illinois Senate Race, Saving Pritzker From Political Embarrassment
The billionaire Democratic governor spent at least $5 million helping his lieutenant governor win the primary.
Watch: Episode 4 of Patriots’ ‘Forged in Foxborough’ documentary
The Patriots released a 90-minute episode to recap their 2025 season.
Scientists create a new state of matter at room temperature using light and nanostructures
Researchers at Rensselaer Polytechnic Institute (RPI) have created a new and unusual state of matter—known as a supersolid—by engineering how light and matter interact inside a nanoscale device. The ...
iPhone 17e Teardown Shows How Apple Made It An Effortless Process To Add MagSafe Charging To The iPhone 16e In A Few Minutes
A teardown performed by iFixit shows that the iPhone 17e is easy to get into and how you can added MagSafe charging to the iPhone 16e
BHP names Brandon Craig as CEO, succeeding Mike Henry
Mining giant BHP Group on Wednesday named Brandon Craig as CEO to succeed Mike Henry, who will step down after more than six years at the helm.
Flickering Pixel 10 Pro display glitch is driving users absolutely crazy, and it's hard to unsee
A very annoying screen glitch is causing a flickering rectangle to appear on some Pixel 10 Pro displays.
Unilever considers separation of its food assets, Bloomberg News reports
Unilever is in the early stages of weighing a separation of its food assets as the consumer goods maker plans to streamline its business, Bloomberg News reported on Tuesday, citing people familiar with the matter.
Is a computer science degree still worth it?
A computer science degree used to be a golden ticket to a well-paying career. Is it still worth it in the age of AI?
UBS faced brief incident that impacted trading business, source says
UBS Group's global technology systems have been nearly restored on Tuesday after a brief incident that impacted some of its trading business, a person familiar with the matter told Reuters.
UBS faced technology outage that impacted trading business, Bloomberg News reports
UBS Group has been working to fix a global technology outage that impacted some of its trading business, Bloomberg News reported on Tuesday. Some trading has been halted during the outage, the report said, citing people familiar with the matter. (Reporting by Akanksha Khushi in Bengaluru; Editing by Maju Samuel)
Kalshi charged criminally in Arizona for operating illegal gambling business
Arizona's attorney general on Tuesday filed criminal charges against Kalshi, accusing the prediction markets platform of operating an illegal gambling business in the state and unlawfully allowing people to place bets on elections.
WATCH: Johnson refutes outgoing counterterrorism official's claim that Iran posed no imminent threat
We Saw Starfield's Big Overhaul and DLC - Is It Enough to Revive Bethesda's Space RPG?
Starfield is getting new DLC, Terran Armada, along with some major quality-of-life updates. And a PS5 version! We got an extended first look at everything on its way to Bethesda's big outer-space RPG.
Scientists Use AI And Simulated Natural Selection To Evolve Real-World Robots
“These are the first robots to set foot outdoors after evolving inside of a computer,” said one of the researchers.
Xbox 360, PS3 And Nintendo Wii U Are "Officially Retro", Says GameStop
"They are still very cool, and anyone who owned one at launch is absolutely not old"
Scientists used 7,000 GPUs to simulate a tiny quantum chip in extreme detail
Researchers have pushed quantum chip design into a new era by simulating every physical detail before fabrication. Using a supercomputer with nearly 7,000 GPUs, they modeled how signals travel and interact inside an ultra-tiny chip. Unlike earlier “black box” approaches, this method captures real materials, layouts, and qubit behavior. The result is a powerful new way to spot problems early and build better quantum hardware faster.
National Eye Institute director speaks during Vision Science Research Center retreat
National Eye Institute director speaks during Vision Science Research Center retreat
Japan's Idemitsu to invest $500 million in Australian Midocean to enter LNG business
Idemitsu Kosan , Japan's second-biggest oil refiner, said on Tuesday it will invest $500 million in Australia's MidOcean Energy as part of a move towards a full-scale entry into the LNG business.
German infrastructure fund failed to spur extra investment, IW says
Germany's special fund for infrastructure has largely failed to generate additional investment one year after its approval, the German Economic Institute (IW) said in a study seen by Reuters on Tuesday.
Alibaba shakeup hints at an AI business model
The $325 bln group is separating its AI initiatives from its cloud computing unit. It’s a nod to a craze for digital agents like OpenClaw and willingness of consumers to pay for these standalone services. Monetising AI will remain daunting but the rejig makes sense.
Identity of Banksy, Oscar-nominated graffiti artist, proven 'beyond dispute'
The identity of Banksy, the notoriously elusive graffiti artist whose work now sells for millions and was the subject of an Oscar-nominated documentary, has finally been proven 'beyond dispute.'
Trump Claims an Ex-President Confided His Regrets on Iran. But Who?
The New York Times reached out to people close to President Trump’s predecessors. They disputed Mr. Trump’s claims.
OpenAI to cut back on side projects to focus on core business, WSJ reports
ChatGPT-maker OpenAI's top executives are finalizing plans for a major strategy shift to refocus the company around coding and business users, the Wall Street Journal reported on Monday.
Primary care consultation modality and acute mental health service use in adults
Nature Mental Health - Using retrospective health-record analyses, Hidalgo-Padilla et al. evaluated whether differences in remote versus in-person primary care consultations were associated with...
Disney names Debra OConnell as chairman of Disney Entertainment Television
Disney on Monday named Debra OConnell as the chairman of Disney Entertainment Television, adding that she will oversee brands including ABC Entertainment, Disney Branded Television, Hulu Originals and National Geographic Content.
Factbox-Lawsuits Against Trump Administration's Health Policy Changes
March 16 (Reuters) - A federal judge on Monday blocked key parts of Health Secretary Robert F. Kennedy Jr.'s effort to reshape U.S. vaccine policy, including a move to reduce the number of shots routinely recommended for children. U.S. District Judge Brian Murphy in Boston sided with medical ...
Politics no stranger to World Cup, Men in Blazers' Bennett says
Politics at the World Cup is "nothing new," Men in Blazers Media Network founder and CEO Roger Bennett said, arguing that the tournament has long been a stage where national history, culture and conflict travel with the teams onto the field.
Iran’s attacks have collapsed, and the trend is ‘overwhelmingly positive,’ analysts say. But the military side is separate from politics and markets
Iranian drone attacks on the United Arab Emirates collapsed from 332 on the second day of the war to just six on Sunday, according to the Institute for the Study of War.
Trump threatens to ‘knock the hell out of’ Iran's Kharg Island in impromptu phone call with PBS News
The comments came during a three-minute phone call Monday morning with PBS News' Liz Landers, while the president was attending what he described as a “very important meeting” on the Iran war.
Exclusive: OpenAI courts private equity to join enterprise AI venture, sources say
OpenAI is in advanced talks with private equity firms including TPG , Advent International, Bain Capital and Brookfield Asset Management to form a joint venture that would distribute its enterprise products across the firms' portfolio companies and beyond, four people familiar with the matter said.
Partisanship and science
I recently participated in a symposium of the Denver-based Institute for Science & Policy, during which I had a “fireside chat” with Tony Mills of the American Enterprise Institute. Mills has written extensively on the politicization of science, and the two of us had a very enjoyable hour-long conversation on the topic. You can watch it below. The main questions we dealt with are why there is such a vast partisan gap in trust of science, and to what extent this is a unique moment. Mills helpfully brings a good deal of data to the discussion, as he did in this useful piece at Issues in Science & Technology. Tusk depends on reader support. To support this work, please become a paid subscriber. Subscribe Note this graph, drawing on a range of survey data to demonstrate partisan attitudes toward science since 1970s. As it demonstrates, there’s been a very sharp partisan divergence in confidence in science during the Trump Era, starting prior to the Covid pandemic. At least in part, we can attribute this to a rise in populist anti-science rhetoric embraced by Trump, his appointees, and those in his media orbit. But as the graph also shows, the partisan divide has existed in the past, and it’s not always in the same direction. The largest divergence in party views toward science prior to 2016 was in the 1970s, when liberals equated scientific achievement with the military-industrial complex and thus trusted it less. That era of scientific mistrust is often overlooked. Indeed, as Mills notes, the Moon landings (1969-72), which today are considered one of the last great moments of national unity, were experienced nothing like that at the time. There was sharp debate back then over whether the Apollo missions were worth the vast expenditures when the country had so much else to deal with. It’s outside the dataset, and we don’t have the partisanship lens for it, but the 1950s was another deeply anti-science decade, with critics of intellectuals and college professors alleging their ties to communism and their lack of commitment to basic American moral beliefs. This was the subject of Richard Hofstadter’s 1962 book Anti-Intellectualism in American Life, in which he quotes religious leaders like Franklin Graham: [In place of the Bible] we substituted reason, rationalism, mind culture, science worship, the working power of government, Freudianism, naturalism, humanism, behaviorism, positivism, materialism, and idealism. [This is the work of] so-called intellectuals. Thousands of these “intellectuals” have publicly stated that morality is relative—that there is no norm or absolute standard.… This fervor was heavily whipped up by Sen. Joe McCarthy (R-Wisconsin), although it’s clear that not all his fellow Republicans were on board with his red-baiting. What ended that era? The simple answer is the 1957 launch of Sputnik. Americans became afraid that they were losing to Soviet scientists, and suddenly university researchers and government projects were awash with funding. In our conversation, I asked Mills about the possibility of us having a Sputnik moment again that would rally the American public in favor of science today. Mills argued that the COVID-19 pandemic was essentially a Sputnik moment — a terrifying threat to all Americans that required scientific advances to address. But thanks in part to political polarization and the populist and conspiratorial leanings of Donald Trump, we got the opposite of a unifying moment. Many Americans turned against science, despite science actually stepping up in that moment. As we discussed in the chat, it’s not clear what scientists could or should be doing in this moment to increase faith in their work. As Mills notes, one of the chief complaints against scientists and professors is that they’ve become too political; scholars becoming even more political might not help them achieve their goals. This (mainly Republican-driven) anti-science era will end, of course, but it’s not clear what event will bring that about. Share
Donald Trump attacks supreme court over tariffs again in late-night social media post
President accuses court of having ‘unnecessarily RANSACKED’ the US and claims he has ‘absolute right’ to impose new tariffs
Large rapamycin clinical trial launches at UT Health San Antonio - UT Health San Antonio
A drug once known almost exclusively for preventing organ transplant rejection is now at the center of a National Institute on Aging-funded clinical study at UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), to determine how rapamycin should be used in older adults to […]
Alibaba CEO takes helm of new AI-focused business group
Alibaba Group CEO Eddie Wu will head its newly formed Alibaba Token Hub business group, which will focus on building artificial intelligence work platforms for enterprises, the firm said in a statement on Monday.
Alibaba CEO takes helm of new AI-focused business group
Alibaba Group Chief Executive Eddie Wu will head the newly formed Alibaba Token Hub (ATH) Business Group, the firm said in a statement on Monday. The new group will comprise existing Alibaba units Tongyi Laboratory, MaaS Business Line, Qwen Business Unit, Wukong Business Unit, and AI Innovation Business Unit. Alibaba said its mission would be to "create, deliver, and apply tokens," and it would focus on building AI-native work platforms for enterprises.