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Crypto billionaires donate millions to Reform UK, raising concerns about money in politics
Reform UK, the anti-immigration party led by Nigel Farage, received £72 million (around €83.9 million) from two cryptocurrency billionaires this weekend, prompting concerns about money’s influence in British politics. Ben Delo, co-founder of the BitMEX platform, donated £36 million, and crypto investor Christopher Harborne matched that amount. Harborne supports Reform UK’s policies, believing they will […]
Saranac Oktoberfest set for three weekends
Saranac Brewery will hold Oktoberfest over three weekends at its Utica biergarten, with food, games, competitions, keg taps and free admission.
Borderlands 4 DLC Character and Free-to-Play Weekend Attract Resurgence on Steam
Borderlands 4 is climbing Steam charts as players fall head over heels for its new DLC character – a Vault Hunter named Loveless the Hacker.
UNC vs. ETSU Live Discussion
The Tar Heels hope to sharpen their blade before taking on Clemson next weekend.
Vasilije Adzic hoping to beat Juventus for Sassuolo this weekend
Juventus sent Vasilije Adzic out on loan to Sassuolo this season, and he will have a chance to show them what they are missing when both clubs meet in Serie A this weekend.There is no doubt Adzic is o...
Crypto billionaires give $97 million to Reform UK, fueling concerns about money in politics
LONDON (AP) — Reform UK, the anti-immigration party led by Brexit campaigner Nigel Farage, received 72 million pounds ($97 million) from two cryptocurrency billionaires this weekend, fueling concerns about money in British politics.
Crypto billionaires give $97 million to Reform UK, fueling concerns about money in politics
Reform UK, the anti-immigration party led by Brexit campaigner Nigel Farage, received $97 million from two cryptocurrency billionaires this weekend.
Crypto billionaires make record donations to UK political party
Reform UK, the anti-immigration party led by Brexit campaigner Nigel Farage, received $97 million from two cryptocurrency billionaires this weekend.
Crypto billionaires give $97 million to Reform UK, fueling concerns about money in politics
LONDON (AP) — Reform UK, the anti-immigration party led by Brexit campaigner Nigel Farage, received 72 million pounds ($97 million) from two cryptocurrency billionaires this weekend, fueling concerns about money in British politics.
Crypto billionaires give $97 million to Reform UK, fueling concerns about money in politics
LONDON (AP) — Reform UK, the anti-immigration party led by Brexit campaigner Nigel Farage, received 72 million pounds ($97 million) from two cryptocurrency billionaires this weekend, fueling …
Crypto Billionaires Give $97 Million to Reform UK, Fueling Concerns About Money in Politics
LONDON (AP) — Reform UK, the anti-immigration party led by Brexit campaigner Nigel Farage, received 72 million pounds ($97 million) from two cryptocurrency billionaires this weekend, fueling concerns about money in British politics. After news broke that Ben Delo, a co-founder of the BitMEX ...
5 Small Business Ideas for People Who Want a 4 Day Workweek
These small business ideas allow for longer weekends by batching jobs, charging recurring fees, or concentrating work on a given four-day period.
The AfD's Dark Agenda for Germany
How the extreme far-right political party is reshaping Germany—and echoing Trump's MAGA movement in the process.
José Javier Rodríguez, Annette Taddeo to spend weekend courting South Florida labor, faith base
Both Democrats are running against incumbents appointed by Gov. DeSantis who hold hefty fundraising edges.
Bayern coach Kompany won't underestimate underdogs Elversberg
Bayern Munich coach Vincent Kompany won't underestimate Sunday's opponents Elversberg, who are making their Bundesliga debut this season and have been the surprise package so far. The underdogs are even two points ahead of the German giants in the standings, with two wins in as many games, while Bayern thrashed VfB Stuttgart in their league opener but were held to a goalless draw by Schalke last weekend.
The politics and possibilities of ‘AI could kill us all’
I found myself fielding a lot of questions from folks who don’t usually talk much about AI this week. They were mostly along the lines of “do you think AI is going to kill us all?” or “how worried should I be about this human extinction stuff?” Motivating this wave of existential anxiety was the highly dramatic resignation of now-former Anthropic employee Jacob Coxon, who quit his job while publicly sharing his concerns about safety practices at the leading AI companies. More specifically, he declared that almost everyone at OpenAI and Anthropic, the leading AI labs, believes that there’s a decent chance the AI systems they’re producing could “kill us all” by the end of the decade, and the companies aren’t “acting responsibly.” Other AI safety researchers, including those still employed at Anthropic and OpenAI, all confirmed that yes, Coxon is correct, they’re all worried that their company’s products might prove fatal for the entire human race as well. Two more AI employees quit and joined the chorus. Now, the warning shot has been covered everywhere from the Wall Street Journal to Fox News to WIRED to the Guardian. I understand why all this sounds scary, but my response to those who have asked, has generally been: No, you don’t need to worry that AI will kill go rogue and kill us all. But that does not mean we shouldn’t worry, period. Far from it. The companies building AI products are now among the wealthiest and most powerful entities in the world. And they very much are building enormous engines of mass surveillance, extraction, and automation. They can and have allowed their AI systems to carry out felony hacks of other companies, provided the government with autonomously generated kill lists, and sold enterprise technology to firms around the world that is explicitly intended to replace jobs. But “AI” has done these things not because they have all-powerful minds of their own but, ultimately, because people have programmed, calibrated, and directed them to. In other words, it’s not AI we need to worry the most about. It’s the people and corporations working to profit from and gain power by deploying it. The technology is sophisticated, sure, and, especially in cybersecurity contexts, potentially disruptive to plenty of existing systems. But if we want to stop this predatory, profiteering, and extractive form of AI—and it’s worth noting that at this point, most people do—we absolutely can. A quick note/plea: I can only do all of this with the support of readers like you, so if you find value in independent, critical tech journalism and analysis, please consider becoming a paid subscriber. I want to keep as much of this un-paywalled as absolutely possible, and I need your support to do so. Many thanks to all who continue to chip in, it’s very much appreciated. Onward. Subscribe First, some context: AI industry folks like Coxon have been discussing the prospect that AI will destroy humanity for years. Even before the beginning of the AI boom, many working in the industry, from the executive staff to the rank and file researchers, have obsessed over ‘x-risk’, or the possibility that AI will become sentient or semi-sentient and move one way or another to exterminate humanity. This is ostensibly why Elon Musk bankrolled OpenAI in the first place, and is the grounds for his lawsuit alleging OpenAI betrayed its charter by abandoning its nonprofit status to become a commercial enterprise. Many AI engineers and startup founders have calculated their own personal p(doom), or the probability that the tech product they are working on will initiate an actual humanity-extinguishing apocalypse. 10-25% p(doom)s are pretty common. (I wrote about a long weekend I spent among these folks at one of their top conferences here, to give you an idea of their ideas and belief systems.) Sam Altman himself drove the narrative of the imminent rise of a super-powerful AI, or artificial general intelligence, to prominence by declaring that the technology he was building posed an existential risk to humanity. This idea is in other words baked into the DNA of modern AI companies and into the products they engineer. It’s also why the industry is routinely accused, by myself and others, of “doom marketing,” ie, using such proclamations and framings to impart the sheer power of the technology behind your product onto investors, partners, consumers, and the state. Some ambient understanding of this tendency may have helped prevent the press from repeating the claim every time one of the x-risk folks made it over the years, including when they quit their jobs at AI companies while doing so. Yet Coxon’s AI x-risk alarm has broken containment, as they say, and has exposed the idea to the mainstream media once again. This has happened, I think, for a number of reasons. First, when AI CEOs were going around saying AI might kill everyone in 2023, their companies were well-capitalized, but not nearly to the extent they are today. They were more easily dismissed as eccentric geeks of the sort that Silicon Valley is supposed to produce. Now, not only do their products have much greater market saturation, but people are more aware of a) the often unethical ways the executives and companies comport themselves b) the other adverse impacts of AI that have already arrived, and c) the physical cost of building these systems, particularly when it comes to data centers. Finally, toss in the constant stream of headlines in 2026 about AI models going rogue or potentially upending the world’s infrastructure. [ ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) [ With the backlash to data centers, Flock and AI glasses, a mass opposition to big tech is underway. Silicon Valley is in denial. ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) Brian Merchant · Aug 27 [ Read full story ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) As a result, general sentiment was already overwhelmingly skeptical of AI and its overlords, so the table was pretty well set for someone to come along and say ‘just a reminder, the companies that are building the product that promises to take your job and leave a data center in your neighborhood also think that it might exterminate the human race’ and get a strong reaction from the media and the public. The question is: Should we understand this stuff as hype, strategically fanned to feed already swelling valuations? Is it doom marketing? Genuine cause for alarm that the infrastructure that undergirds modern life is facing a novel threat vector? Or reason to be sincerely worried that AI companies are amassing too much power, and that their products are genuinely dangerous? The answer, I’m afraid, is “yes.” Let me try to untangle all of this a bit, because arguments over how to navigate this moment are extremely heated right now, as they are essentially arguments over how to approach the politics of AI at a moment where there may be a unique opening for action. Those sympathetic to AI alignment concerns and x risk arguments—which increasingly includes a faction on the left who want to shut down AI over safety concerns—argue that people who dismiss AI as all hype have their heads in the sand. Meanwhile, critics of the x-risk narrative—which I might note includes a cadre of investors and tech folks on the right, too—argue that it is hype and can be used to further inflate valuations or for pursuing regulatory capture. The challenge is that many feel that dismissing AI as just hype or purely marketing also diminishes the urgency of taking on the AI industry as the novel and threat to labor, civil society, and the public sphere it is; others that by accepting the industry’s own terms, we imbue it with undue power and enable it. But let’s be clear: Declarations that AI is so powerful it might end the world are a kind of marketing, and anyone who says otherwise is just as off base as those who say that’s all that it is. If you don’t think that these sub-trillion dollar companies have higher-ups who noticed that when their founders talked about super-powerful dangerous AI they got spikes in media interest and phone calls from investors, or that those founders didn’t notice that themselves, and lean into certain narratives to advantage their products, then I don’t know what to tell you. Not all marketing is a Pepsi ad campaign with a celebrity spokesperson. Yet confronting the AI industry should certainly be considered an urgent project. Do I share the x-riskers’ fear that out-of-control, super-intelligent AI agents might end the world? I do not. I’ve read a good deal of AI extinction literature over the last couple of years and I have not come across a credible, step-by-step documentation of how exactly AI might move from self-recursively improving AI to killing every single human on the planet. Most of what I’ve read seems predicated on a sort of reverse Ian Malcolmian logic: Eventually, it becomes smart enough and AI, uh, finds a way (to exterminate humanity). Are the AI companies also overstating and dramatizing what their products can do? Yes, pretty much all the time. They’re in a knife fight for market share and are trying to win customers and government contracts before their investors come knocking. And yet. They have concentrated enormous amounts of compute, have extensive data collection and surveillance capacities, have inserted themselves into the state in numerous capacities, including military kill chains, and they are being run by egomaniacal billionaires who are rushing to monopolize an entire new market. The way I think about their most recent frightening-seeming exploits is not as a “swarm of rogue AI agents building a new civilization” or whatever, but as corporations with a hitherto-unimaginable amount of compute at their disposal recklessly experimenting with automation programs, completely unafraid of any repercussions because we have been unwilling or unable to impose any on them. So I think we should welcome any newfound imperative to hold them accountable. I also think that ultimately, the AI critics, Pause AI folks, leftists, doomers, effective altruists, and, honestly, most of the public, want a lot of the same things: legitimate checks and limits on AI companies’ power, actual transparency into what the companies are doing, and for more of AI to be under public control. (Ultimately, a lot of what animates the x-risk fears are rooted in just that: a fear of losing control.) How we move towards all this, exactly, is the question of the day, and while there’s much to be argued over in terms of building a viable political platform to challenge the AI industry’s power, I do want to cast a vote against one particular approach. Not to pick on Chris here, as there are a lot of folks out there proposing stuff like this, and the policy ideas actually stem from AI safety groups. But not only would this be challenging to land politically (I can already hear the ‘China will beat us to AGI’ calls) and all but unworkable in practice, this approach is a) far too limiting, b) fails to address the current harms caused by AI and c) would likely only wind up serving Anthropic and OpenAI; it’s what regulatory capture looks like in action. Full model transparency is the floor for what should be on offer here. If these companies believe their products will kill us, the very least we deserve is to know how. It’s in the public interest. I would also argue we might get a lot of the way to stopping any currently envisioned robot apocalypse simply by forcing AI companies to assume liability, and to submit to the full brunt of the law. If Sam Altman were liable to be charged with a felony for approving the hack on Hugging Face1, if Google was forced to pay defamation fines each time it published a false and injurious AI Overviews, these companies might suddenly find cause to restrain their models’ output, and we might hear less about rogue AI. We would need to introduce new frameworks and available tools for tracking automated lawbreaking, to be sure, but I’d wager that little would frighten the AI companies more than actually being held accountable for what their products enable. To that end, Illinois has passed an AI liability law, which the industry fought tooth and nail, and Florida is considering one. The next steps would be towards moving AI under public control; again, it’s only reasonable, since everyone, not just AI insiders, should get a say over how a technology whose developers say might kill us is developed and deployed. Dismantling the whole industrial project as currently structured should be on the table, too, pending democratic input. But that’s for another post. For now, suffice to say that while I won’t be losing any sleep about an AI-enabled extinction event, Mr. Coxon and co. have given us an opportunity to underscore the urgency of the clear and present damage AI companies are doing, the extreme power they wield and the extent to which they hold themselves unaccountable, and the abundance of political capital there is out there for taking them on. Subscribe 1 Purely speculative! I do not know if he did or not.
Chelsea vs Hull City – Predicted lineup and team news
Chelsea host Hull City at Stamford Bridge on Saturday looking to respond to their first Premier League defeat under Xabi Alonso, a 2-1 loss at Arsenal last weekend. The Blues needed a dramatic second-...
After GOP convention, Trump heads to his Irish resort
President Donald Trump was heading to Ireland on Friday for a weekend at his golf resort, after two days spent trying to energize Republicans for the midterms.
GALLERY: Ball State College of Health hosts Block Party
Ball State College of Health hosts Block Party, an event that serves as the kickoff for Family Weekend, starting Saturday, September 12th. The event went from 5:00 pm to 7:30 pm on the courtyard between the Health Professions and Foundational Sciences buildings. Block Party featured free popcorn, shaved ice, pins, games, and music. Attendees were also able to take photos at a selfie station and as well as listen and watch the Ball State Studio Band perform throughout the event.
St. Louis Cardinals vs Chicago White Sox Game Discussion Friday
The St. Louis Cardinals begin a weekend homestand against the Chicago White Sox Friday night as Matthew Liberatore will get the start for St. Louis while the White Sox will send Anthony Kay to the mound. First pitch is scheduled for 7:15pm with the game broadcast available via Cardinals.tv.
Dodgers on Deck: Saturday, September 12 at Marlins
The Dodgers and Miami Marlins continue their weekend series with an afternoon game on Saturday at loanDepot Park, a 4:10 p.m. start time locally and 1:10 p.m. back in Los Angeles. Tyler Glasnow takes the ball for Los Angeles, making his fourth start since returning from the injured list. Right-hander Tyler Phillips starts for the […]
Forest as kinship system: science Educator Peter Kindfield at the Nature Center this weekend
Science educator Peter Kindfield will be conducting a special nature walk this Sunday, Sept. 13, at the Idyllwild Nature Center.
“Hope”, “Colin From Accounts”, and “Project Runway” top this week’s Must List
“The Calamities” and the “Chess” 2025 Broadway cast recording round out our picks for the weekend of Sept. 11.
Youth sides have five matches in Cotia this weekend
The Under-20, Under-17, and Under-15 teams will play this Saturday at CFA Laudo Natel, in Cotia, in the Paulista Championship. On Sunday, it will be the turn of the Under-13 and Under-14 sides to play...
Mystery Science Redux at the Majestic This Weekend
The noble art of cracking wise at bad movies is one of the last of our culture's great oral traditions to be co-opted by professionals. But co-opted it was, in the late ’80s, by Mystery Science Theatre 3000, which at its best was humblingly brilliant TV.
Sunderland v Arsenal: Key stats and talking points
Arsenal will look to extend their perfect start to the new season when they face Sunderland at the Stadium of Light on Saturday (20:00 BST) in the Premier League. Arsenal have also won all three of their league games so far this campaign, making a strong start to the defence of the title they won last season. Sunderland have bounced back well after an opening-weekend loss to Ipswich Town, taking four points from games against Fulham at home and Brentford away in their subsequent fixtures.
Enjoy Illinois 300 and Confluence Music Festival return
The Enjoy Illinois 300 returns to World Wide Technology Raceway Sept. 11–13, bringing NASCAR’s top drivers back to Madison for the fifth year. But the weekend has grown into more than a race. The Confluence Music Festival has become a cultural staple alongside the event, drawing thousands with a lineup that blends national acts and […]
Banana Ball brings 3 days of baseball, entertainment to Lexington
Baseball meets entertainment this weekend in Lexington. Banana Ball is taking over CommonSpirit Ballpark with three sold-out games.
How Brewers Can Clinch Division Title, Playoff Spot vs. Reds
The Milwaukee Brewers enter a critical weekend series needing just one victory to punch a postseason ticket while eyeing a fourth straight division crown.
Tulane Looks to Not Define Season With Uncertainty at Quarterback
The Tulane Green Wave are still searching for their successor at quarterback and hope that they're right this weekend.
The biggest fall concerts coming to the Seattle area
From classic rock legends to new-school hitmakers, these are the biggest fall concerts coming to the Seattle area through Thanksgiving weekend.
Eyewitness Sports Scoreboard for Friday, September 11
The first week of school is nearing its end, but high school and college soccer pitches are running full speed into the weekend and beyond! We had a full night on local pitches and football fields all over the Mohawk Valley, and you can catch up with all of it on the Friday edition of the Eyewitness Sports Scoreboard!
Defining His Race: How a Charlotte Motorsports Leader Found a New Heart and a Second Chance
After experiencing subtle symptoms one Easter weekend, Charlotte Motor Speedway President and General Manager Greg Walter suffered a massive heart attack that led to cardiac arrest, advanced life support, and a heart transplant at Atrium Health Sanger Heart & Vascular Institute. Today, Greg is back at the track with a renewed perspective on life, leadership and recovery.
Mid-Michigan entertainment for the weekend of Sept. 4-6 and beyond
Check out what’s going on around the region.
Pierre Sage Calls For Togetherness Ahead Of Ipswich
Pierre Sage has spoken to the media ahead of Palace vs Ipswich this weekend, and shed light on his squad fitness and their approach to the game.
Addressing security concerns for political candidates
Conversations on how to prevent safety issues are continuing after authorities say an armed man lunged at Dr. Amy Acton during an appearance over the weekend.
Sept. 11 - Panda Fest to make its Savannah debut in October
September 11, 2026 - Panda Fest, one of the largest outdoor Asian food and culture festivals in the United States, will make its Savannah debut during the weekend of Oct.
How concerned should big-spending Tottenham be after winless and goalless start to Premier League season?
Spurs are yet to win or score in the Premier League this season despite a big summer of spending; Roberto De Zerbis side also failed to have a shot on target last weekend; watch Tottenham vs Everton on Saturday, live on Sky Sports Premier League from 5pm; kick-off 5.30pm
Place Your Bets: Michigan vs. Oklahoma
Michigan lost to Oklahoma last year in Norman so the Wolverines are out for revenge this weekend in The Big House.
Marietta businesses prepare for 50th anniversary Sternwheel Festival
Marietta’s 50th anniversary Ohio River Sternwheel Festival kicks off Friday, and local business owners are preparing for the big weekend.
HOMETOWN ENTERTAINMENT: Concert, festival and a creepy speakeasy highlight weekend hometown events
Festival returns to downtown Salem Saturday with free admission
Gorilla Heavy Hitters hosts Night of Champions in Midland
ODESSA, Texas (KMID/KPEJ) – This weekend, local boxing promotion Gorilla Heavy Hitters will be hosting its “Night of Champions” event. Multiple local boxers will be featured, showcasing West Texas talent, as Big Belt Champion and featherweight contender Conrad Martinez headlines the main event, facing off against the undefeated (15-0 13 KO) Victor “Jalapeno” Hernandez. Night […]
11 things to do around the Seattle area this weekend
From late summer soft-serve to a multicultural celebration with a focus on Muslim culture, here are the latest local things to do around the Seattle area.
Festivals of Aloha brings Aloha Friday to Queen Kaʻahumanu Center on Sept. 11
Festivals of Aloha continues its 2026 season with Aloha Friday at Queen Kaʻahumanu Center on Friday, Sept. 11, from 5 to 8 p.m. The free, family-friendly evening invites the community to kick off the weekend with live Hawaiian entertainment, cultural demonstrations and activities for the entire ʻohana.
James Franklin Looks to Continue Virginia Tech’s Strong Start
Virginia Tech is back at Lane Stadium this weekend, and the Hokies will be looking to build on one of the most dominant performances of the opening week. The Hokies will host Old Dominion on Saturday at noon ET in a matchup that carries plenty of intrigue. Virginia Tech opened the 2026 season with a…
Must Watch Sun Belt Games in Week 2
Several Sun Belt teams will have an incredible opportunity this weekend to test themselves against major Power Four opponents. From Louisiana’s trip to Southern California to Louisiana Tech's in-state battle against LSU, there are a number of games that are worthy of tuning into. These Sun Belt teams can potentially prove themselves to the world …
Best of Santa Cruz County entertainment, arts & food events this weekend, Sept. 10-13
With the weekend nearly here, check out things to do around Santa Cruz County, with a recommendation from Lily Belli and a specially curated list from Lookout's BOLO events calendar.
Will Cambiaso and McKennie play Juventus’ next match?
Andrea Cambiaso and Weston McKennie are two Juventus players facing minor injury concerns ahead of their match against Sassuolo this weekend.Cambiaso missed their last match against AC Milan, while Mc...
Boston Red Sox Announce Probable Starters Against Kansas City Royals
Just when it looked like the Boston Red Sox were closing the gap on the New York Yankees in the race for the first American League wild-card spot, a bump in the road hit. New York took three out of four from Boston two weekends ago in the Bronx to go four games clear for […] The post Boston Red Sox Announce Probable Starters Against Kansas City Royals appeared first on HEAVY.
The Central American Voices Film Festival is coming to Los Angeles
The Central American Voices Film Festival (CAVFF) is a Los Angeles–based film festival taking place this weekend and is dedicated to amplifying the stories, cultures, and creative voices of filmmakers
Weekend Entertainment | Nelly, Elvis Costello and a Lot More
A spree of big-name concerts that will hit town in the next few days should have fans of every music genre smiling.
MusiCares to honor U2 as 2027 Persons of the Year at a star-studded Grammy-weekend gala
MusiCares will honor Irish band U2 as its Persons of the Year at a gala in February.
MusiCares to honor U2 as 2027 Persons of the Year at a star-studded Grammy-weekend gala
MusiCares will honor Irish band U2 as its Persons of the Year at a gala in February | KNX News 1070 AM
MusiCares to honor U2 as 2027 Persons of the Year at a star-studded Grammy-weekend gala
MusiCares will honor Irish band U2 as its Persons of the Year at a gala in February | KCBS All News 106.9FM and 740AM
MusiCares to honor U2 as 2027 Persons of the Year at a star-studded Grammy-weekend gala
MusiCares will honor Irish band U2 as its Persons of the Year at a gala in February | WWL
4 The Weekend: Fall for some great entertainment in Tucson
TUCSON, Ariz. (KVOA) — Feel a different kind of heat, talk a walk to fight hunger and get the blues from two iconic jazz masters. All part of the fun
A new album from Wilmington's musical royals, plus your weekend
If Wilmington has musical royalty, then Fuzz Jackson and McClain Sullivan should wear crowns. Their lush new album, "Heide Drive," dropped Sept. 8.
Sage on Doucoure, team spirit and Ipswich
Crystal Palace boss Pierre Sage has been speaking to the media before Saturday's Premier League game against Ipswich Town at Selhurst Park (kick-off 15:00 BST). Midfielder Cheick Doucoure is in contention to be part of this weekend's squad. Sage also confirmed that Jean-Philippe Mateta remains unavailable to face Ipswich.
What's cooking at the Manship, rocking out at LASM and more: 3 things to do this weekend
Our top three picks for your weekend
2026 Heisman Week One Poll
Welcome to the 2026 Heisman Week One poll. We had a very full and long weekend of football games. There has been some movement in our weekly Heisman Poll. Arch Manning and CJ Carr both dropped out of the poll. They both received minimal votes and were barely a blip on our radar. Miami made …
Snapchat takes aim at Partiful with new event-planning features
Snapchat says the new features can be used to organize everything from birthday celebrations and sporting events to study sessions and weekend hangouts.
Things to do this weekend and beyond in Gainesville and Alachua County
Looking for that perfect Halloween costume? Check out Dance Alive National Ballet and Next Generation's Great Halloween Costume Sale.
Dortmund's Karetsas out of weekend game but Schlotterbeck may return
Borussia Dortmund's Konstantinos Karetsas will miss Saturday's Bundesliga home game with Paderborn but is not expected to be out long-term. The 18-year-old Greek, who has made a strong start to his Dortmund career after moving in the transfer window from Genk, was substituted in the first half of Dortmund's 3-2 Champions League win against Villarreal on Tuesday due to circulatory problems.
Walla Walla Fair parade brings crowd to Main Street
Attractions abounded for the weekend crowd of Walla Walla Fair and Frontier Days on Saturday, Sept. 5, both at the fairgrounds and in downtown Walla Walla.
Michigan Football injury updates ahead of Oklahoma game
Michigan Football 5-star freshman edge rusher Carter Meadows is “hoping to play” against Oklahoma this weekend. Here’s the latest on that and other injuries:
Weekly Entertainment Report: Live music and lively arts, Sept. 10-13
Go out and find yourself some good live entertainment this weekend.
What a Labor Day weekend show
I moved to Miami in 1969 and have called it my home town ever since. I had a girlfriend that attended the University of Miami so I spent a good
2027 Infield Landscape Ever Changing
At one time, Leo De Vries was on such a fast track that it seemed inevitable that he would be a big factor by the 2027 season. One torn labrum later (shoulder surgery scheduled this weekend) and he won’t even be back on a minor league field until mid-May. So the presumptive starters along side […]
Coon Valley Dairy Supply celebrates 80 years in business
Coon Valley Dairy Supply will celebrate 80 years in business this weekend.
Before construction on Commanders stadium begins, roster of small business contractors needs to be filled
While the Commanders will be kicking off their first game of the season this weekend against the Philadelphia Eagles, the team behind the new stadium at the old RFK site is looking to fill out their rosters with subcontractors and small businesses.
Here's the Complete Hardly Strictly Bluegrass Day-By-Day Lineup for 2026
The full lineup for San Francisco's favorite free music festival is now out, and we now know who's playing on which day the first weekend in October.
Comedy headliners jam the metro area this weekend
This weekend is loaded with headliners in larger theater settings, making for a particularly busy time for comedy fans.
Crooked Letter Sports: First football weekend, first takes.
By and large, Mississippi’s college football teams had a successful first weekend and the Clevelands break it down game by game, with some high school
PFT's Week 1 2026 NFL picks
My not-for-betting purposes look at all 16 opening-weekend games.
What’s new in theaters this weekend?
The return of witchy sisters, a church group hunted by spiders, CIA operators in Tehran, a new rock doc and more hit theaters this weekend.
Week 1 NFL Schedule 2026: How To Watch Kickoff Weekend
As the 2026 NFL season gets started, this is your guide around where and what to watch from Wednedsday's kickoff all the way through Monday Night Football.
Prayers flooding in for country music star after medical emergency. Here’s what we know
The singer's team shared the news during the weekend.
These are the best things to do in Brevard this weekend, Sept. 11-17
Find your weekend adventure! Zoo days, live music and theater auditions top our list of Brevard's best things to do.
8 events in Lancaster County this weekend, from a whoopie pie festival to an herb fest
There's a lively weekend on tap for Lancaster County.
Folarin Balogun almost fit to make AS Monaco return
Folarin Balogun (25) could be included in AS Monaco’s squad for the game against RC Lens next weekend, as per a report from L’Équipe.Monaco manager Filipe Luís revealed that Balogun had been pla...
Jacks look to continue playing ‘fresh’ in Week 3
SIOUX FALLS, S.D. (KELO) — SDSU fell to 1-1 on the season after a 34-18 loss at Northwestern over the weekend. The Jacks struggled to convert in the red zone but otherwise hung around with the Wildcats for the majority of the night, only trailing by two with eight minutes to go in the fourth. […]
Harrisburg Senators unveil 2027 schedule
HARRISBURG, Pa. (WHTM) — The Harrisburg Senators unveiled their 2027 season Tuesday. The Senators’ home opener is Friday, April 2, against the Chesapeake Baysox. The team will host 69 games at FNB Field. Other notable home games include Mother’s Day on May 9 vs. the Richmond Flying Squirrels, as well as Memorial Day weekend through […]
Monster Jam coming to Gwinnett this weekend
Long before she made a name for herself on the insanely popular Monster Jam circuit, Kayla Blood approached and cleared her share of hurdles.
From Backyard Ziplines to Self-Driving Cars: UCLA Computer Science Student Develops Tools to Help Autonomous Vehicles Safely Share Information
One of the fondest childhood memories of Alexandra Markova was a weekend spent running around Home Depot with her father and three siblings.
Everton's Has Selection Headache Heading Into Tottenham Clash
Selection headaches are something a manager can often dream of, and David Moyes could have them heading towards Everton's game against Tottenham in the Premier League this weekend.
Area high school girls flag football players join GN Sports to talk about event this weekend
Wisconsin alum, rapper Yung Gravy supports local business during Badgers vs Notre Dame game
GREEN BAY, Wis. (WFRV) – Matthew Hauri, better known by his stage and rapper name Yung Gravy, made an appearance in Green Bay over the weekend to support Wisconsin, his alma mater, in their g…
Penguins unveil roster for upcoming prospect tournament in Detroit
The Penguins have announced the roster for the team’s upcoming prospect tournament that’s being held in Detroit, starting this weekend. Pittsburgh, along with Columbus, Dallas and Detroit will be participating in a prospect tournament in Detroit with games on Saturday, Sunday and Tuesday. All of the games will be streamed on the Penguins’ website. 27 […]
Honda Postpones Big Upgrades to 2027
The Japanese brand's trackside boss confirms no significant evolution this year. The AMR26's lack of top speed showed at Monza, with Alonso and Stroll posting the weekend's worst times.
Russia launches massive, deadly, and ‘complex’ attack against Ukraine
Fighting between Ukraine and Russia commenced after a 72-hour pause for diplomatic visits to both countries by U.S. officials. Russia launched a massive attack on Ukraine on Tuesday, firing dozens of cruise missiles and over 140 drones as the war raged on after this weekend’s peace talks brokered by U.S. envoys Jared Kushner and Steve […]
The debate on whether WEC prioritised 'entertainment' over 'sport' in Austin
WEC hosted its Austin round last weekend, but did the series go too far in its pursuit of an entertaining race?
Oil prices surge back toward $100: What market pros are saying
Oil is creeping back toward $100 a barrel, fueling a Labor Day record for US gas prices over the long weekend.
ON THE MARK: Acclaimed blues band Blueprints returns to Madison Hall
You don’t need an intricate plan to build a fun time this weekend.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Cleveland Armenian Festival returns to Richmond Heights this weekend
St. Gregory of Narek Armenian Church hosts the annual event Friday evening and all day Saturday.
Juventus fans attack their team’s mindset over Federico Gatti’s celebration
Federico Gatti saved the day for Juventus when they faced AC Milan at the weekend, but his reaction after scoring has frustrated the club’s fans.The Bianconeri were the better team during the match,...
Oil prices keep rising and weigh on Wall Street
U.S. stocks are drifting lower in their return to trading following a three-day weekend. The S&P 500 dipped 0.2% Tuesday. The Dow Jones Industrial Average fell 477 points, and the
Harrison Smith Returns — And the Cap Gets Complicated
Harrison Smith's $12.25M return, cap concerns, bold predictions, and an NFL Rivalry Weekend pitch.