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iPhone 18 Pro Color Leak: Meet the New Burgundy Red (and Say Goodbye to Black)
iPhone 18 Pro color testing points to burgundy as the main theme, with black excluded for a second year; foldable models stay neutral.
Dollywood discounts are here for the park and resorts. See who qualifies
Dolly Parton’s theme park has discount tickets and special rates for resort stays for community heroes. But the offer is only for a limited time.
North Dakotans can learn about resources to grow healthy habits on April 18 at Gateway to Health event | Health and Human Services North Dakota
Individuals and families are invited to the fourth annual Gateway to Health community event, which includes activities for all ages on Saturday, April 18, 10 a.m.- 4 p.m. at North Dakota’s Gateway to Science in Bismarck. Participants will enjoy free access to the science center during their registered two-hour time slot, along with access to interactive booths and exhibits promoting health and wellbeing through hands-on activities, games and prizes.
When and why political leaders polarise rhetoric: Evidence from Twitter/X
Standard theories of electoral competition predict that politicians should converge toward the centre as elections approach. This column challenges this prediction, using 3.4 million tweets from 367 political leaders across 21 Western democracies. Rhetorical polarisation between populist and non-populist leaders rises sharply in the two quarters before an election and reverts to average levels once it is over. Both groups adopt a more emotionally direct communication style as elections near, but they increasingly talk about different topics. The findings suggest that social media turns electoral campaigns into an engine of political polarisation.
More women in politics does not always mean more gender equality
Evidence on the policy impact of female politicians is mixed. This column uses data on bills sponsored in the Italian House of Representatives between 1987 and 2022 to show how female politicians’ engagement with women’s issues is systematically related to the gender norms of the environments in which they were born. The findings suggest that while increasing the number of women in politics remains essential to broaden representation and diversify policy priorities, if social norms remain traditional, progress on gender equality may still be slow.
African American Health Symposium highlights support for those impacted by Alzheimer's
This year's theme: "It Takes a Village: Faith, Family and Community in Caregiving."
‘Shoutout’: Caleb Hearon talks comedy, queerness, politics, and more at latest SPB event
Life advice. Dream blunt rotations. An accidental 6-7 joke. Comedian Caleb Hearon brought it all to the Clark-Fox Forum in front of a packed crowd of WashU undergraduates last Wednesday, April 1. Student Union’s Social Programming Board (SPB) teased the event for weeks leading up to the show.
Which U.S. metros have the highest health spending? The answer might surprise you
There's not a consistent theme among the 10 highest and lowest spending metros, which highlights the “irrationality” of U.S. health care spending, experts say.
ENTERTAINMENT: Dogtown Throwdown in Argenta; UCA stages ‘Little Women’
Main Street between Fourth and Fifth streets in the Argenta Arts District in North Little Rock will shut down Friday and Saturday for Dogtown Throwdown, two days of outdoor dining, live music and “family-friendly activities” with a Cajun theme.
Washington State Ousted This Health Insurance Lookalike. In Oregon, It Carries On.
From one vantage, the story of Zion HealthShare shows Washington to be an overzealous nanny state. From another perspective, Oregon might stand to learn from its consumer-protection-minded neighbor to the north.
BetMGM, Borgata add NFL-themed virtual games in New Jersey
Borgata Online also launched V-Play Soccer and Basketball, widening Inspired's reach in New Jersey after BetMGM said Ontario saw positive player response.
Kalamazoo production to bridge exploitation and entertainment during piano fest
"Good Night, Oscar" examines the intersection of humor and heartbreak while exploring themes of mental illness, celebrity exploitation, and entertainment’s impact on society.
How a NISTer Watches ‘Project Hail Mary’
Measurement science shines in the new hit film Project Hail Mary.
Looks like Sony is Testing a New PlayStation 5 Dashboard Design, and Fans Hope Full Themes Are Next
A new PlayStation 5 update is testing a fresh design for the console's dashboard, fans say.
2026 North Carolina Science Festival in April
The North Carolina Science Festival (NCSciFest), a month-long, statewide celebration of science, returns in April 2026 with the theme “Science Matters.” Produced by Morehead Planetarium and Science Center, with presenting sponsor RTI International, NCSciFest features hundreds of interactive events designed... View Article
Affordability and Preventive Public Health Policy
Affordability pressures increasingly shape health risk in the United States, influencing both the upstream conditions that sustain health and the downstream ability to access health promoting resources. Financial stability is a key driver of health, affecting patterns of health, health care use, and the tradeoffs people must make among competing needs. The economic policy landscape aimed at improving financial security for Americans is expansive, complex, and often difficult to organize, making it challenging to discuss how different policies influence financial resilience and population health. We propose the Earn–Keep–Grow framework as a practical way to organize and guide discussion of these policies in population health research and policy decision-making.
Google just launched a special-edition Pixel, but you probably can't buy it
The phone celebrates a decade of Google Pixel and introduces exclusive wallpapers alongside custom-themed icons.
World Health Day 2026: Together for health. Stand with science
On World Health Day 2026, celebrated on 7 April, WHO unites and mobilizes the world under the theme “Together for health. Stand with science.” celebrating the power of scientific collaboration to protect the health of people, animals, plants, and the planet. The year‑long campaign spotlights both scientific achievements and the multilateral cooperation needed to turn evidence into action.
World Health Day 2026: PAHO/WHO calls for renewed commitment to science to drive better health for all
6 April 2026, Geneva / Washington, DC-- The World Health Organization (WHO) and the Pan American Health Organization (PAHO) call on people everywhere to renew their commitment to science as the foundation for better health, under the World Health Day 2026 theme: “Together for health. Stand with science.” The campaign marks the anniversary of WHO’s founding on 7 April, launching a year-long public health campaign.
Mario’s box office boom reveals a bigger trend in themed entertainment
Super Mario Galaxy movie drives a record Easter weekend as theaters see strong attendance, merchandise sales, and ties to theme parks.
WHO calls for action: “Together for health. Stand with science.” to mark World Health Day
The World Health Organization (WHO) today calls on people everywhere to renew their commitment to working together and supporting science as the twin engines driving better health, under the World Health Day 2026 theme: “Together for health. Stand with science.” The campaign marks the anniversary of WHO’s founding on 7 April 1948, launching a year-long public health campaign.
WHO calls for action: “Together for health. Stand with science.” to mark World Health Day
The World Health Organization (WHO) today calls on people everywhere to renew their commitment to working together and supporting science as the twin engines driving better health, under the World Health Day 2026 theme: “Together for health. Stand with science.” The campaign marks the anniversary of WHO’s founding on 7 April 1948, launching a year-long public health campaign.
Lebanon’s political elites are using displacement and humanitarian crisis to delay elections again
With the return of Israeli forces, the Lebanese parliament scrapped elections scheduled for May. The move is a recurring theme in the country’s fractured politics.
Super Mario Run Celebrates The Super Mario Galaxy Movie With A New Event
Unlock some themed statues
New Business: Slightly Crooked Pies opens on Manchester’s Elm Street, The Mallard lands in Londonderry
Entering Slightly Crooked Pies on Elm Street in Manchester, customers are taken back in time. The homey wallpaper features cherries in the design to fit the theme, and the space
Ranking Member Lofgren Blasts Trump Budget Request
The House Committee on Science, Space and Technology
National Public Health Week is ready, set for action
NPHW 2026 will take place next week, April 6-12. Its theme is “Ready. Set. Action!,” which supports a bold approach to improving health and wellness, meeting the moment with clarity and positivity, and engaging in collaboration and partnerships to make things happen.
2026 National Public Health Week
Each April, National Public Health Week shines a spotlight on the systems, people, and partnerships that keep our communities healthy. This year’s theme —Ready. Set. Action! — was chosen by the American Public Health Association (APHA) and calls on each of us to look back at the progress made and look forward to the steps needed for an even healthier future.
U.S. 63 and Business U.S. 30 Roundabout Construction in Toledo Begins April 6
U.S. 63 and Business U.S. 30 Roundabout Construction in Toledo Begins April 6
TEA to bring themed entertainment industry together at Liseberg
BURBANK, Calif. — The Themed Entertainment Association (TEA) is excited to announce the reschedule of the 2026 TEA SATE EME conference which will now take place 6-9 July in Gothenburg, Sweden. The …
Sullivan Legislation to Increase Mental Health Awareness and Resources on Social Media Passes Senate
The Official U.S. Senate website of Senator Dan Sullivan of Alaska
The Crossword, March 30: Feeling Good (Themeless)
It’s time to wrap up the month with a challenging themeless. Keep an eye out for tricky clues and fun wordplay. This week’s puzzle was constructed by Rafael Musa and Owen Bergstein, and edited by Hoang-Kim Vu. Defector crosswords, launched in partnership with our friends at AVCX, run every Monday. If you’re interested in submitting a puzzle to us,…
Availability of Care for Older Adults in Outpatient Behavioral Health Facilities
Behavioral health (BH) conditions are rising among older adults, who are less likely to receive mental health (MH) or substance use disorder (SUD) treatment compared to younger adults. This study examined the availability of care for older adults in outpatient BH facilities across the United States both quantitatively and qualitatively.
Zendaya teases bridal-themed fashion with something old, new, borrowed ... and soon, blue?
l e weddings fashion entertainment lifestyle | 104.1 FM KMOX
Zendaya teases bridal-themed fashion with something old, new, borrowed ... and soon, blue?
l e weddings fashion entertainment lifestyle | KNSS Radio
A leaker claims Nintendo is set to release Zelda-themed limited edition Switch 2 to tie in with release
A leaker with an unproven track record, Shpeshal Nick, has stated that Nintendo is planning to release a limited edition The Legend of Zelda: Ocarina of Time Nintendo Switch 2 console to tie in with…
Fort Worth Chamber Debuts Centennial Club
At the 2026 Annual Meeting: The Modern Chamber, the theme highlighted how legacy institutions build upon long-standing foundations while continuing to evolve fo
Annual Sugar Sand Festival brings massive hand-sculpted art and entertainment to Clearwater Beach
The annual event's theme this year features sports and American 250 sculptures, running through April 12, with the help of over 400 volunteers.
World of Frozen Opens at Disneyland Paris’ New Disney Adventure World
New Frozen-themed land headlines major expansion at Europe’s iconic Disney resort.
Riverhounds unveil USL championship banner, top Sporting Club Jacksonville in home opener
AMO, the mascot for Riverhounds SC, has a new look. For one, the furry fellow has adopted black, Riverhounds-themed high-top sneakers. When AMO —...
The geography of science
Scientific activity has historically been concentrated in a small number of advanced economies, but the global landscape of research is undergoing rapid transformation. Using data on 44 million publications from 1980 to 2022, this column examines how the geography of science has evolved along three dimensions: where research is produced, what topics it studies, and where it is consumed through citations. It documents a substantial shift in scientific production from traditional Western leaders s emerging economies. Yet scientific attention and knowledge diffusion remain uneven, revealing a tension between the global expansion of scientific capacity and the continued fragmentation of the knowledge system.
Inside Gainesville’s Most Immersive Escape Room: How Movie-Set Experiences Are Changing Entertainment
HCA North Florida OB/GYN doctors solving puzzles inside a wizard-themed escape room in Gainesville, Florida
Old Forge library offers daily craft sessions during spring break
Old Forge Library will host free daily spring break craft sessions March 30 to April 10, featuring themed projects for all ages.
Sights from SBJ’s Business of Soccer Day 2
Business of Soccer wrapped up at Mercedes-Benz Stadium in Atlanta on Thursday, with speakers like Arthur Blank discussing the state of the sport.
Dollywood adds another race weekend for runners. When, how to sign up
Dolly Parton's theme park will host a second race weekend later this year after the inaugural spring event nearly sells out.
New Dems Hear from Small Businesses on the Harmful Impacts of Tariffs
The Official Site For The New Democrat Coalition
The United States Senate Committee on Finance
Republican Cuts Are Wrecking Health Care for American Families
Billy Goat Hole Ramp at Dauphin Island Back in Business
Official Web Site of Alabama Department of Conservation and Natural Resources
Sights from SBJ’s Business of Soccer Day 1
SBJ’s Business of Soccer conference began Wednesday at Mercedes-Benz Stadium in Atlanta, starting with a panel featuring MLS Commissioner Don Garber, FIFA VP Victor Montagliani and U.S. Soccer President Cindy Parlow Cone.
Zac Brown Band Stars in NBC Sports’ New Sunday Night Baseball Theme (DETAILS)
The Zac Brown Band is bringing some country rock vibes to NBC and Peacock's Sunday Night Baseball.
Decoding the Visual World
Learn how NSF's long-standing investments helped computers learn to identify and interpret images, advancing technologies now integral to people's daily lives.
Kali Linux 2026.1 released with 8 new tools, new BackTrack mode
Kali Linux 2026.1, the first release of the year, is now available for download, featuring 8 new tools, a theme refresh, and a new BackTrack mode for Kali-Undercover.
Accelerating Innovative and Effective Pediatric Health Care Delivery Systems: Interventions and Value-Based Care Models for Children with Chronic Health Conditions and Complex Social Needs
Children, youth, and families have unique health needs, which set the foundation for health across the life course; chronic conditions now affect nearly one in three U.S. children, with disproportionate prevalence in those enrolled in Medicaid and CHIP.
Age Comes for Us All—Even Politicians
Don’t look now, but the period from now through the 2028 presidential election will be a historic inflection point in our politics. We’ll see enormous generational change take place amid enormous uncertainty and volatility.
Mojang partners with Merlin Entertainments for the world's first Minecraft theme park, Minecraft World
Mojang has partnered with Merlin Entertainments to build the world's first Minecraft theme park in the UK.
Uplifting and Not Ceding Ground on Health Equity Practice Is Critical to Strengthening Public Health and the Health of the Nation
Public health science gains in the last quarter century in the United States have been formidable due to a focus on structural and social determinants of health, thereby enhancing understanding of the role of inequitable policies in shaping health inequities and inequitable access to ameliorative resources.
US soccer legend Landon Donovan details mental health struggles in new book
American soccer great Landon Donovan talks to Fox News Digital about the themes in his new book, "Landon: A Memoir."
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Margaret Cho on comedy, politics, and life in Hollywood
Comedian and actress Margaret Cho discusses her penchant for tackling political themes in her performances, evident in her upcoming tour, "Choligarchy,” coming to the Englert Theatre Friday, March 27.
Business investment in the era of digital transformation
The weak performance of business investment across the OECD since the Global Financial Crisis holds back potential growth. However, it masks a strong investment dynamic in digital assets such as hardware, software, and databases. This column describes how this divergence between digital and non-digital assets has intensified from the mid-2010s. The strong investment performance of the US relative to the rest of the OECD is almost exclusively a digital phenomenon. A ‘digital divide’ is emerging, where laggard countries are accumulating digital capital per worker more slowly than those with higher initial starting levels.
Minecraft World Opening 2027, First Look at $70 Million Project
Theme park lovers who yearn for the mines will have their wish granted in 2027 with the debut of Minecraft World, based on the popular building video game.
Minecraft World Is Coming To Chessington World Of Adventures In 2027
The land will include new attractions including a world-first Minecraft coaster, themed retail and dining, plus a host of fan favourites and ridiculous fun from the Minecraft universe.
"Mega Shine" Set Announced for "Pocket!"
The next Pokemon TCG Pocket set will be named Mega Shine (B2b) and will release on March 26th! As its name implies, it will feature shiny
HHS announces first Rural Health Transformation Program funding opportunity to strengthen rural health care workforce | Health and Human Services North Dakota
North Dakota Health and Human Services (HHS) today announced the first Rural Health Transformation Program funding opportunity is now available to support the retention of health care professionals in North Dakota’s 37 critical access hospitals and their owned and operated clinics. The deadline to apply is 5 p.m. CT April 30.
Devolver Digital and doinksoft announce fantasy action platformer Dark Scrolls for Switch, PC
Publisher Devolver Digital and developer doinksoft have announced Dark Scrolls, a fantasy-themed side-scrolling action platformer that “fuses shoot ’em up-style chaos with roguelite pro…
Madison influence adds to 'Our Town' universal themes
University Opera's production of Thornton Wilder's story links his Madison roots with a new generation of UW students.
A Massive Midterm Wave Isn’t Forming Yet. Here’s Why.
This is an era not just of hyperpartisanship, but of negative partisanship, in which partisans often hate the other side even more than they love their own. Many voters thus tend to see everything on a binary basis. Any given election outcome is seen as either a landslide victory or an unmitigated disaster. There is little appreciation, or even tolerance, for gradations between those outcomes.
House Committees on Science, Space, and Technology and Small Business Celebrate Passage of SBIR/STTR Reauthorization Bill on the House Floor
The House Committee on Science, Space and Technology
House Committees on Science, Space, and Technology and Small Business Celebrate Passage of SBIR/STTR Reauthorization Bill on the House Floor
The House Committee on Science, Space and Technology
Contributor: War abroad, injustices at home and a theme running through it all
For a template to connect the public’s wariness about war with concerns about affordability and xenophobic immigration policies, look to the late Rev. Jesse Jackson.
YouTuber upgrades MacBook Neo to 1TB in new ASMR video
YouTube creator DirectorFeng is back with another ASMR-themed video in which they attempt to upgrade the storage on a new Apple device.
Dolly Parton Shares Health Update After Postponing Vegas Shows
Dolly Parton paid a visit to her theme park in Pigeon Forge, Tennessee, and shared an uplifting update on her health after canceling some recent appearances and postponing her Vegas residency.
Jurassic Park River Adventure Replaces Old Track, Aerial Photos Show
Refurbishment work is moving along at a steady pace on the Jurassic Park-themed water ride at Universal Studios Florida.
Dolly Parton shares health update, squashes dating rumors – 'Carl Dean is waiting for me'
The country music legend, 80, offered fans a health update at the opening day of her Dollywood theme park. She also said she won't marry again.
Jodi's Journal: Business anniversary meets AI arrival
As we mark nine years in business, we thank you so much for supporting us! In today's column, Jodi details the theme that appears ready to define the next nine years.
Centennial Students Earn 3rd Place at Iowa Regional Science Bowl
Michael Stevens, Ian Anderson, Anna Bruns, Jared Bond, Alice Baghdasaryan and teacher Madison Greif. (Not pictured: Team Manager Vivian Zhang.) Congratulations to our outstanding team for earning 3rd place at the 2026 Iowa Regional High School Science Bowl, held on the campus of Iowa State University on March 7! We’re proud of these students for representing our school with excellence in this challenging academic competition that tests knowledge in science, mathematics, and teamwork.
Pittsburgh businesses ready for 2026 NFL Draft
Jim Coen expects his football-themed merchandise to fly off the shelves when the 2026 NFL Draft comes to town April 23. “I’m projecting this NFL Draft to be like two Super Bowls combined,” said Coen, who owns Yinzers in the Burgh, a Strip District store dedicated to all things Pittsburgh
"Perfect Order" Set Guide: Full Set List, Product Lineup, Store...
We now have the full English set list for Perfect Order starring Mega Zygarde ex! It will release on March 27th. Prereleases will take place from
Manalapan couple's découpage business creates music for your eyes
Stuck on Découpage in Manalapan crafts custom découpage turntables, guitars and music-themed gifts as well as wooden boxes, frames, trays and more.
CSU Spur hosts Girls & Science themed 2nd Saturday
March is Problem Gambling Awareness Month: free, confidential support available statewide | Health and Human Services North Dakota
Gov. Kelly Armstrong has officially proclaimed March 2026 as Problem Gambling Awareness Month in North Dakota. March is also recognized nationally as a time dedicated to raising awareness about gambling-related harm and connecting individuals and families with support. North Dakota Health and Human Services (HHS) encourages everyone to learn the warning signs of problem gambling and to reach out for help when needed.
AFSCME Sues to Stop Politically Motivated Termination of Public Health Grants
The American Federation of State, County and Municipal Employees (AFSCME) and its Illinois affiliate, AFSCME Council 31, have filed a federal lawsuit challenging the Trump-Vance administration’s directive.
How generational turnover and party switching reshape the US political map
Political polarisation has increased dramatically in the US in recent decades and is often linked to partisan geographic segregation. This column presents new evidence from 2008 to 2020 that reveals an increase in partisan segregation even at very local levels. However, while most studies focus on one explanatory factor, residential mobility, we find that generational change (in Democratic-trending areas) and Democrats leaving their party (in Republican-trending areas) explain a much larger share of the rise in partisan segregation.
West Family set to open duck-themed entertainment venue 'Buffleheads' in South Knoxville
Celebrity sighting: Actress among first to ride LEGOLAND’s new space-themed coaster
Mandy Moore and her family were among the first to experience the new LEGO Galaxy attraction at LEGOLAND California Resort, which features an indoor family coaster and other cosmic rides.
Sakurai reveals that he wrote the lyrics for Kirby Air Riders' main theme song, explains why he kept it under wraps
Director Masahiro Sakurai reveals that he was behind the lyrics for Kirby Air Riders' main theme song and explains why he kept it a secret.
Celebrity sighting: Actress among first to ride LEGOLAND’s new space-themed coaster
Mandy Moore and her family were among the first to experience the new LEGO Galaxy attraction at LEGOLAND California Resort, which features an indoor family coaster and other cosmic rides.
Advancing Climate Action Together is theme of MI Healthy Climate Conference
The MHCC is expected to draw more than 900 attendees from across the state and nation.
Manchester City v Nottingham Forest: Key stats and talking points
Manchester City go in search of a seventh consecutive win in all competitions, hosting relegation-threatened Nottingham Forest. BBC Sport examines some of the key themes before Wednesday's match (19:30 GMT). Manchester City were without their top scorer for the visit to Leeds – the city where the Norwegian was born – but nonetheless recorded another important victory to keep the pressure on leaders Arsenal.
What to know before asking an AI chatbot for health advice
Tech companies are pushing new health chatbots, but experts say you still need to talk to your doctor.
Tribute rock and DJ nights lead two weeks of casino entertainment
Live entertainment including tribute rock, DJs and themed events is scheduled across Northern California tribal casinos March 2–15.
Tribute rock and DJ nights lead two weeks of casino entertainment
Live entertainment including tribute rock, DJs and themed events is scheduled across Northern California tribal casinos March 2–15.
Franklin Park hosts adult-only 'Cocktails at the Conservatory' nights
Franklin Park's "Cocktails at the Conservatory" series offers themed adult-only nights with drinks, food and live music. See the full 2026 schedule.
Weekend Pulse: 2/27-3/1
Concerts, classic film, live game shows and a maple-themed dinner highlight a full weekend of entertainment across the region.
120-unit Bay City apartment complex closer to construction, medieval-themed brewery and more local business n
Looking to stay caught up on Bay City-area business news? Check out these recent headlines.
2026 San Francisco Worlds Key Art Revealed; PokemonXP and Worlds...
The key art for this year's World Championships was just revealed during today's Pokemon Presents! TPCi also announced that starting April 2nd at 6 PM
Pokémon-Themed Mini Game Boy Announced, Though It's Not What You Think
Music to your ears?
NVIDIA to give away GeForce RTX 5090 Resident Evil Requiem edition GPU
NVIDIA launches Resident Evil Requiem GeForce RTX 5090 sweepstake NVIDIA has published official rules for a Resident Evil Requiem themed GeForce RTX 5090
The Pokémon Center’s Game Boy Jukebox Hits All the Right Notes
Game Boy Jukebox features 45 cartridges bumping classics like “Pallet Town Theme.”
Partnership Leads to New Model for Building the Future of Themed Entertainment
UCF and AOA are launching a new scholars program to provide hands-on professional practice to themed experience graduate students.