Search headlines

Ocasio-Cortez and Sanders push bill to impose AI data center moratorium

A bill introduced by two high-profile progressive lawmakers would pause new data centers in the United States until national safeguards are in place to protect workers and consumers and ensure the technologies don’t harm the environment.

Mar 25 • 5:33 PM EDT • Politics • pbs.org

Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com

In politics, common decency still matters

I am a conservative. He was a progressive. Still, we had many productive conversations and worked together on a few important issues where our views converged.

Mar 25 • 1:01 AM EDT • Politics • carolinajournal.com

Sherrill flexes political muscle in midterm battle between moderate Democrats and progressives

New Jersey Gov. Mikie Sherrill launches Mission to Deliver PAC, aiming to boost moderate Democrats in key federal and statewide 2026 midterm races.

Mar 24 • 2:45 PM EDT • Politics • foxnews.com

Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com

Subtle health changes may signal progressive supranuclear palsy years in advance

Drawing from UK Biobank data, Mass General Brigham researchers have uncovered specific health factors linked to higher or lower risk of developing progressive supranuclear palsy (PSP), a rare but devastating ...

Mar 24 • 11:00 AM EDT • Health • medicalxpress.com

Opinion | Climate Science Is Creeping Into Courtrooms

Judges are fed biased information from progressive activists and a flawed scientific reference manual.

Mar 24 • 10:55 AM EDT • Science • wsj.com

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com

Maine progressive Senate candidate Graham Platner responds to Gov. Janet Mills’ attack on his online past

Mar 22 • 9:50 AM EDT • Politics • cnn.com

Politics Unplugged (Full Episode) March 22, 2026

This week on Politics Unplugged, Progressive activist Kai Newkirk explains why he is running to unseat Democratic incumbent Greg Stanton in the congressional race in CD4. Then, consultants Marcus Dell’Artino and Matt Grodsky discuss the fallout from the Cesar Chavez allegations and the political importance of high gas prices.

Mar 21 • 6:29 PM EDT • Politics • azfamily.com

Not all business owners: How Business for Good is building a new voice in San Diego

Business for Good, a network of San Diego business leaders, advocates for progressive causes in the region.

Mar 21 • 12:00 PM EDT • Business • timesofsandiego.com

3 Democratic pastors in Iowa are running for Congress, a snapshot of a national trend

More Democrats are openly running on faith, as progressive clergy and other religious candidates push back on the idea that Christianity belongs to the right

Mar 20 • 7:06 AM EDT • Politics • washingtonpost.com

“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp

Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.

Mar 20 • 6:43 AM EDT • Entertainment • kevinmlevin.substack.com

Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment

Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share

Mar 19 • 6:34 PM EDT • Entertainment • theankler.com

New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

Mar 19 • 5:28 PM EDT • Technology • gamefile.news

Cornyn clashes with progressive Rep Greg Casar in heated airport face-off over DHS shutdown

Texas Sen. John Cornyn and Rep. Greg Casar clashed over the DHS shutdown as TSA workers missed their first paycheck and airport delays continue to mount.

Mar 16 • 3:41 PM EDT • Politics • foxnews.com

In Illinois, Clashes Over AIPAC Erupt As House Campaign Closes

In a Democratic primary, accusations are flying that allies of a hard-line pro-Israel group are trying to divide progressives, exploiting a broader rift in the party.

Mar 15 • 7:41 PM EDT • Politics • nytimes.com

Slow downtown recovery testing Seattle’s pragmatic progressives

At Wednesday’s annual Downtown Seattle Association gala, local progressive politicians tried to demonstrate their practical, pro-business side.

Mar 13 • 9:00 AM EDT • Business • seattletimes.com

How Pope Leo's Catholic Church is Influencing U.S. Politics

Pope Leo is changing how the American Catholic Church operates, energizing progressive Catholics.

Mar 10 • 7:05 PM EDT • Politics • kqed.org

How Much of Science Is Fake?

For decades, scientists were above reproach. Not any more. Joe Nocera investigates the murky world of fraudulent research, and the sleuths exposing dishonest science.

Mar 10 • 1:54 PM EDT • Science • thefp.com

Longtime State College business owner prepares to retire, close final store

The Barefoot shoe store will run a progressive markdown sale to liquidate its inventory of shoes, clothes and more.

Mar 9 • 5:42 AM EDT • Business • centredaily.com

Ask Secretary of State candidates if they’re in favor of independent election audits

This part will disappoint angry people on Twitter: Relax. Put the pitchforks down. I am not relitigating the 2020 election or mail ballots or even Tina Peters. But I am saying people don’t trust elections like they used to. And here in Colorado we can do a rather simple thing to reverse that. And progressives […]

Mar 8 • 7:00 AM EDT • Politics • coloradopolitics.com

Capcom delivered a marketing masterclass with Resident Evil Requiem

Mar 5 • 9:30 AM EST • Technology • thegamebusiness.com

Why progressives' single-payer health care dream would bankrupt California

Mar 4 • 9:01 PM EST • Health • nypost.com

James Talarico wins the Texas Democratic Senate race. The real challenge lies ahead.

After the state representative won the Senate primary, he joined a list of other promising progressives who have captured the left’s fancy.

Mar 4 • 5:24 PM EST • Politics • nytimes.com

‘STRAIGHT OUTTA CONGRESS’: Top progressive concedes race after viral mockery for ‘embarrassing’ defeat

Progressive star Rep. Jasmine Crockett, D-Texas, conceded her race for U.S. Senate after suffering an “embarrassing" defeat to a much lesser-known Democrat, state Rep. James Talarico.

Mar 4 • 11:11 AM EST • Politics • foxnews.com

Progressive lawmakers Bernie Sanders, Ro Khanna unveil $4.4T wealth tax targeting billionaires

Progressive lawmakers Bernie Sanders and Ro Khanna unveil a 5% annual wealth tax on billionaires' assets exceeding $1 billion to fundamentally reshape America's current tax system.

Mar 3 • 10:43 AM EST • Business • foxbusiness.com

Crockett vs. Talarico. Progressive vs. Moderate. Right?

The Texas Democratic Senate primary is more about persona than policy, and the same is true for many other races.

Mar 3 • 5:06 AM EST • Politics • nytimes.com

North Carolina House Primary Includes Divisions on Iran War, Israel and A.I.

A new ad from a progressive challenger, Nida Allam, attacks Representative Valerie Foushee over financial backing she has received from defense contractors and the A.I. industry.

Mar 2 • 3:44 PM EST • Politics • nytimes.com

UX Roundup: AI is the Computer | Disrupting Filmed Entertainment | UX Trends | GOMS | Nano Banana 2

Summary: The AI is the computer | AI is disrupting the filmed entertainment industry | UX trends for 2026 | AI can use the GOMS UI analysis method | New image model: Nano Banana 2 | New music model: Lyria 3

Mar 2 • 7:21 AM EST • Entertainment • jakobnielsenphd.substack.com

MAGA Calling Newsom Racist? That’s Rich

Gavin Newsom has been reveling in the attention that comes with being the early frontrunner for the 2028 Democratic presidential nomination. But the California governor also seems to understand that he has work to do to convince voters that he’s more than just a slick-talking, coastal elite with progressive politics and a pretty face. To that end, he spent much of last week in the South promoting his new memoir, “Young Man in a Hurry.”

Mar 1 • 8:00 AM EST • Politics • bloomberg.com

Measles and echo chambers, fresh science, and more

Behind the Curtain (Feb 27)

Feb 27 • 8:31 AM EST • Science • yourlocalepidemiologist.substack.com

Buried by Snow—and by Shaky Science

It feels like snowstorms are becoming more intense, but science tells us that we don’t really know, writes Roger Pielke Jr.

Feb 24 • 10:48 PM EST • Science • thefp.com

Upstate pols question $1.5B NYC boost vs. $150m upstate

The additional funding came as Hochul has steadfastly resisted calls from Mamdani and other progressives to raise taxes on the wealthy

Feb 23 • 9:23 PM EST • Politics • spectrumlocalnews.com

Business Organizations React To SCOTUS Ruling On Tariffs

Business organizations across the political spectrum from conservative to progressive are in general agreement with the Supreme Court ruling on Friday on tariffs.

Feb 23 • 2:30 PM EST • Business • forbes.com

Roper: Stakes are too high for City Council’s performative politics over hotel liquor licenses

Progressives seem intent on kneecapping one of downtown’s most important event venues, the Depot, just when the city most needs visitors.

Feb 18 • 3:05 PM EST • Politics • startribune.com

Ocasio-Cortez took her populism global. Will she take her politics national?

Speculation is — once again — stirring about a potential Oval Office bid after the progressive star made her first visit to the Munich Security Conference.

Feb 18 • 5:00 AM EST • Politics • ms.now

Sources: Tencent secretly funded struggling shooter Highguard

Wildlight Entertainment has said for years it was "fully-funded" but not shared details.

Feb 17 • 3:18 PM EST • Entertainment • gamefile.news

Obama’s Reminder About the Futility of Purity Politics

The late, great journalist Mark Shields often propounded the idea that politics should be about looking for converts rather than punishing heretics.

Feb 17 • 7:15 AM EST • Politics • liberalpatriot.com

Apple's next event is set for March 4

Rumors had suggested the company would reveal new iPads and MacBooks that week.

Feb 16 • 9:59 AM EST • Technology • engadget.com

Tom Steyer, billionaire populist? Full interview with Inside California Politics

(Inside California Politics) — Tom Steyer is running in a unique lane in the race to be California’s next governor: a billionaire populist, a progressive businessman. “We don’t normally see candida…

Feb 15 • 2:30 AM EST • Politics • fox40.com

Labour factions vie for influence over Starmer’s reset after McSweeney exit

Groups sensing chance to redefine party’s direction push for progressive pivot, cabinet reshuffle and new economic tack

Feb 13 • 8:00 AM EST • Politics • theguardian.com

Ocasio-Cortez’s political clout grows after recent progressive wins

Rep. Alexandria Ocasio-Cortez (D-N.Y.) is seeing her political influence grow among Democrats as chatter builds about her future. Ocasio-Cortez had her latest win over the last week when her endors…

Feb 11 • 6:00 AM EST • Politics • thehill.com

Opinion | The Left Needs a Sharper A.I. Politics

The future may put progressive theories of work and human nature to the test.

Feb 10 • 5:40 PM EST • Politics • nytimes.com

Salt & Stone's Nima Jalali Approaches Brand Collaborations as 'Fun,' Not Business

Watch as the body-care brand's founder and CEO discusses his pro-snowboarding background, opening an NYC store and more, on The Fashionista Network.

Feb 9 • 10:00 AM EST • Business • fashionista.com

Kamala Harris relaunches 'Kamala HQ' social media account for political engagement

Fox News contributor Joe Concha weighs in after former VP Kamala Harris relaunched her 'Kamala HQ' social media account, now rebranded as 'Headquarters,' aimed at progressive youth and discusses TPUSA's alternate halftime show.

Feb 6 • 7:17 AM EST • Politics • foxnews.com

Alexandria Ocasio-Cortez Steps Onto a Wider Stage

The progressive lawmaker is taking a larger role in Democratic politics, supporting moderate candidates and helping drive the party’s economic message. Now she is planning a major trip abroad.

Feb 6 • 5:02 AM EST • Politics • nytimes.com

Thailand's popular progressives are leading the polls - but winning is only the first hurdle

The country votes again this weekend after three years of political turmoil.

Feb 5 • 6:36 PM EST • Politics • bbc.com

Mamdani endorses Hochul for reelection as New York governor

New York City Mayor Zohran Mamdani has endorsed Gov. Kathy Hochul for reelection, offering the moderate governor some progressive heft in her campaign for a second full term

Feb 5 • 10:12 AM EST • Politics • washingtonpost.com

Shaky political science: academics holding each other accountable

A rare occurrence: two academics call out two others for their sloppy and misleading research

Feb 4 • 9:32 AM EST • Science • democracysos.substack.com

Politics Chat, February 3, 2026

A newsletter about the history behind today's politics.

Feb 3 • 7:28 PM EST • Politics • heathercoxrichardson.substack.com

Amy Klobuchar navigates thorny politics of immigration as first test in run for governor

The moment will test Klobuchar’s record of bipartisan work in Washington and relationships with Minnesota progressives, who want a fighter against the Trump administration.

Feb 1 • 7:00 AM EST • Politics • startribune.com

How the left can win back the internet – and rise again

In the final part of this series, we look at how infighting has ripped the left apart online while the right has flourished – and how some progressives are turning the tide, says digital media academic Robert Topinka

Feb 1 • 3:00 AM EST • Politics • theguardian.com

Book Review: “Do Aliens Speak Physics?” asks whether science is truly universal or shaped by the limits of human experience

Andy Warner and Daniel Whiteson have created a witty, illustrated inquiry into what the search …

Jan 31 • 12:30 PM EST • Science • nwprogressive.org

Guardians News and Notes

The equipment truck departs from Progressive Field today.

Jan 29 • 8:00 AM EST • Sports • coveringthecorner.com

Politics Chat, January 27, 2026

A newsletter about the history behind today's politics.

Jan 27 • 7:35 PM EST • Politics • heathercoxrichardson.substack.com

McKee finally endorsed a millionaire’s tax. Progressives and business groups aren’t happy.

Gov. Dan McKee's endorsement of a millionaire's tax in his fiscal 2027 proposal has reignited a longstanding policy debate, with progressive lawmakers saying McKee's proposal does not go far enough, and business groups slamming any income tax hikes.

Jan 23 • 5:30 AM EST • Business • rhodeislandcurrent.com

Sphere Entertainment’s New Playbook: Smaller Venues, Less Risk, Bigger Returns

The $2.3 billion Las Vegas Sphere looked like a financial disaster at first glance, but a deeper look reveals why smaller venues may be the key to making the entire model work.

Jan 22 • 11:33 AM EST • Entertainment • huddleup.substack.com

Politics Chat, January 20, 2026

A newsletter about the history behind today's politics.

Jan 20 • 7:19 PM EST • Politics • heathercoxrichardson.substack.com

Big Business Should End Its Faustian Bargain With Trump

He’s out of control – and if you don’t hang together to counter him, you’ll hang separately

Jan 19 • 6:27 AM EST • Business • paulkrugman.substack.com

Push for ICE reforms could impact government funding effort

The Congressional Progressive Caucus announced it would oppose any proposed funding for immigration enforcement in the DHS spending bill until reforms are enacted.

Jan 13 • 6:06 PM EST • Politics • spectrumlocalnews.com

Tamika Catchings back with Pacers Sports & Entertainment in newly created role

The Hall of Famer, former Indiana Fever star, and community leader is returning to Pacers Sports & Entertainment as organization ambassador.

Jan 13 • 3:03 PM EST • Entertainment • fieldhousefiles.com

Review & Giveaway: Designer Science

Experiencing a crisis of faith from encountering the teachings of modern science is a rite of passage for many Christians.

Jan 13 • 12:49 PM EST • Science • publicwitness.wordandway.org

Nourish + Bloom Market Wins AT&T Small Business Contest

24/7 autonomous grocery store chain receives $50K and more

Jan 13 • 10:43 AM EST • Business • progressivegrocer.com

Kontigo: Y Combinator's Venezuelan Sanctions Evasion Startup

JPMorgan Served as On-Ramp For Users of Maduro Regime-Linked Crypto Company

Jan 11 • 8:59 AM EST • Business • fintechbusinessweekly.substack.com

Nintendo Switch 2 sales stumble over Christmas

Jan 8 • 9:04 AM EST • Business • thegamebusiness.com

Trump suddenly sounds a lot like a progressive Democrat when it comes to business

President Donald Trump made two extraordinarily unusual policy statements in rapid succession Wednesday that sent stocks sinking and raised serious questions about the limits of presidential power in a free-market economy.

Jan 8 • 12:01 AM EST • Business • cnn.com

Portland City Council fails to elect next president amid fractious political fight

The 12-member council will resume deliberations Thursday as progressive caucus member Sameer Kanal vies with incumbent Elana Pirtle-Guiney for leadership position.

Jan 7 • 11:18 PM EST • Politics • oregonlive.com

California Tech Executives Plot Against Rep. Ro Khanna Over Support of Wealth Tax

It’s hard right now to be a progressive Democrat in the heart of America’s tech industry.

Jan 7 • 12:44 PM EST • Politics • nytimes.com

Is There a Science to Finding Love?

An evolutionary anthropologist separates fact from fiction on love, attachment, dating apps, pheromones, and why so much modern relationship advice gets human nature wrong.

Jan 5 • 5:02 AM EST • Science • thefp.com

Zohran Mamdani Supporters Celebrate “Politics of Optimism” at His Inauguration

Tens of thousands of New Yorkers braved freezing temperatures and police barricades to be part of Zohran Mamdani’s inauguration as mayor on New Year’s Day. Democracy Now! spoke with many Mamdani supporters, including a high school student and Palestinian activist Mahmoud Khalil, about what the day represented to them, their hopes for the new administration and how it could set a model for progressives across the country. “Organized people will always be more powerful than organized money,” said Diana Moreno, a fellow democratic socialist who is running for Mamdani’s vacant seat in the New York State Assembly.

Jan 2 • 8:00 AM EST • Politics • democracynow.org