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Roblox's Peter Yang says AI is coming for corporate life
Roblox product lead and content creator Peter Yang spoke on a16z's podcast about AI's potential impact on corporate work and entrepreneurship.
‘Healthy Rounds’: Inquiring About Quality, Patient Safety
Dr. Scott Allen, UConn Health’s chief medical officer, joins Dr. Anthony Alessi’s podcast
NFL mock draft: Arizona Cardinals take Rueben Bain 3rd overall
Sam Monson dropped his mock draft on his podcast. See who the Arizona Cardinals' pick is at third overall.
Spotify's prompted playlist feature will now work for podcasts, too
Spotify will now allow users to input natural language prompts to create podcast playlist.
Brewing Better Health highlights the power of public health partnerships and celebrates National Public Health Week
A Brewing Better Health podcast conversation with Chad Kingsley, M.D., MBA, and Dean Muge Akpinar-Elci, M.D., MPH, on prevention, community health and what public health is.
Supreme Court sides with Steve Bannon in bid to dismiss Jan. 6 conviction
The influential right-wing podcaster spent four months in prison for defying a subpoena from the House panel investigating the 2021 assault on the U.S. Capitol.
Supreme Court clears way for Trump DOJ to wipe out Steve Bannon's conviction
Bannon, now a host of a popular MAGA podcast, was convicted in 2022 for defying a subpoena from the House committee that investigated the Jan. 6, 2021 attack .
Supreme Court paves way for Steve Bannon contempt case to be dismissed
Bannon, a Trump ally and podcaster, already served a four-month prison sentence for defying congressional subpoenas to testify about the Jan. 6 attack on the Capitol.
Science Will Win season finale explores AI in cancer care with Pfizer Chief Oncology Officer Jeff Legos
In February, Pfizer launched the sixth season of Science Will Win, our flagship podcast which recently reached 3 million downloads. The season finale focuses on the future of technology and artificial intelligence (AI) —and what they could mean for cancer research and care.
Vox Launches America, Actually, a New Video-First Podcast Hosted by Astead W. Herndon
The show offers a sharp, on-the-ground look at American politics, built for how audiences watch and engage today.
Vox Launches America, Actually, a New Video-First Podcast Hosted by Astead W. Herndon
The show offers a sharp, on-the-ground look at American politics, built for how audiences watch and engage today.
East Lansing Insider Podcast: A Conversation with Acorn Health
On this week's podcast, ELi Deputy Editor Anna Liz Nichols talks about autism awareness and acceptance with Paul Doher, national director of clinical quality for Acorn Health.
This Week in Politics: Early voting starts this week in New Jersey's special congressional election | WNYC | New York Public Radio, Podcasts, Live Streaming Radio, News
The political world is paying close attention to a race to fill Governor Sherrill's vacated congressional seat.
The brutal truth about NBA health and how it can end playoff dreams
The Wine and Gold Talk podcast breaks down why availability — not talent — determines championship runs, and the Cavs are walking a dangerous tightrope heading into the playoffs.
OpenAI isn’t just buying a podcast
OpenAI’s out-of-the-blue acquisition of TBPN, the buzzy online talk show, stunned the worlds of media and technology. But it’s a continuation of a pattern that dates back a hundred years, to 1926, when RCA created NBC in part to sell radios.
Election conspiracy, new voter law and rebuilding Cuba: IFP podcast
Arrested election worker sparks conspiracies, why a new voter law could prove disruptive and Gov. Ron DeSantis tells exiles to go rebuild Cuba.
Mount Sinai to integrate OpenEvidence AI enterprise-wide
By embedding OpenEvidence directly into its Epic electronic health records, the New York health system aims to change how its clinicians access health data at the point of care to improve patient outcomes.
Brandon Lake on Religion, Politics, and Jelly Roll
Christian music star Brandon Lake says he worries about Christianity being exploited by politics in a new interview on Nashville Now podcast.
Top Sports Podcasts in the United States
Edison Podcast Metrics captures the top Sports podcasts among U.S. weekly podcast listeners 13+ for 2025.
How to poop better, according to a gastroenterologist | Science Friday
For many of us, what happens in the bathroom stays in the bathroom: According to a recent survey, 1 in 3 Americans are too embarrassed to talk about their poop or gut issues with thei...
Cardi B and Steph Curry earn Webby Award nominations, along with Sydney Sweeney's bathwater
f s e media-and-entertainment-industry software podcasts sports technology language celebrity politics internet business entertainment | KMBZ
Jenny McCarthy endures 'living hell' as hidden dental infection leads to shocking health crisis
Jenny McCarthy says mycotoxin poisoning caused her jawbone infections, missing teeth and eyelid growths, calling the ordeal a "living hell" on the "Heal Squad" podcast.
The cost to jobs and public health from the EPA rollbacks (Episode 30)
The US Environmental Protection Agency has announced a major deregulation of greenhouse gas emissions, effectively repealing 25-year-old emission standards for all light, medium, and heavy vehicles and engines of model years 2012 to 2027 and beyond.
Cardi B and Steph Curry earn Webby Award nominations, along with Sydney Sweeney's bathwater
f s e media-and-entertainment-industry software podcasts sports technology language celebrity politics internet business entertainment | KNX News 97.1 FM
PODCAST: Houston Texans Mock Draft 2.0
Who could the Texans select in the 2026 NFL Draft?
Coatue Projected $1.995 Trillion Valuation for Anthropic in 2030
In a presentation to prospective investors in January, Coatue offered a rare look at how it justifies Anthropic’s heady valuations. An anonymous source sent me the slides, which give a unique look at how a top investment firm values Anthropic’s business. This is a moment in time when some of America’s most valuable, growing technology companies remain private. In the January presentation, Coatue estimated that Anthropic would lose $14 billion in EBITDA on $18 billion in revenue in 2026, ending the year with $30 billion in annualized run-rate revenue. Most recently, it’s been reported that Anthropic is at $19 billion in ARR, which could suggest Anthropic is already running ahead of Coatue’s expectations. By 2031, Coatue projected that Anthropic would be generating $48 billion in EBITDA profits on $200 billion in revenue, with $224 billion of ARR. That would give Anthropic a 41x forward EBITDA multiple at a projected $1.995 trillion valuation in 2030. Coatue told the investors it was pitching that Anthropic could be worth $2.413 trillion in 2031. In February, Coatue co-led a $30 billion Series G investment in Anthropic that valued it at $380 billion. Coatue declined to comment on this story. I first shared this slide and talked about the presentation on my new podcast, the Cerebral Valley Show, which I host with my CVAI co-hosts Max Child and James Wilsterman. I’ve got a few other slides from the Coatue presentation for Newcomer subscribers.
East Lansing Insider Podcast: Mental Health in College and East Lansing
Reporter Dustin DuFort Petty speaks with Michigan State University student Andelina Storm Grossi who recently published her first book, Sanity in the Storm: Faith, Healing, and Hope for the Anxious Soul.
3 Insights Into the Future of Business From “The Diary of a CEO” Podcaster Steven Bartlett
What you need to know about agent maxxers and paper walls.
Tudor exit 'inevitable' after Forest loss
Former Tottenham Hotspur goalkeeper Brad Friedel, speaking to BBC Radio 5 Live's Football Daily podcast about Igor Tudor's departure: "After the Nottingham Forest game [which Spurs lost 3-0 on 22 March] - although I hate seeing this merry-go-round of managers - I thought it was inevitable." The long-term solution and building can't take place until you know whether you're building from the Championship or the Premier League.
JD Vance warns that extraterrestrials are demons: 'I'm going to get to the bottom of this'
JD Vance does not believe that 'celestial beings' who 'fly around and do things to people' are aliens. 'I think they're demons,' the vice president said on a recent podcast appearance, vowing to 'get to the bottom of this.'
Las Vegas Raiders GM John Spytek speaks on Crosby trade
Las Vegas Raiders general manager John Spytek spoke on the Maxx Crosby trade for the first time on a recent podcast
Jeff Bezos Says 'I Would Love To See A Trillion Humans Living In The Solar System' — Then We Could Have '1,000 Mozarts And 1,000 Einsteins'
Amazon founder Jeff Bezos isn't thinking small. He's thinking a trillion people big. On the "Lex Fridman Podcast" in 2023, Bezos laid out a vision that sounds more like science fiction than a business...
Politics Unplugged Podcast: Jeremy Duda on ICE restrictions
Axios reporter Jeremy Duda talks about the ICE restrictions in Phoenix and his new book on the murder of journalist Don Bolles. Then Dennis and Colin share their dislike for “old school” coaches.
Versant, Owner of MS NOW, in Talks to Acquire Vox Media’s Podcast Division
Versant, the parent company of CNBC and MS NOW, is looking to continue expanding its business beyond cable TV.
Rumor: Zelda: Ocarina of Time remake and new Star Fox game coming this year, no 3D Mario until 2027
Insider NateTheHate has provided an update on a variety of Nintendo projects, including rumors about Zelda remake, a new Star Fox game, and the lack of a 3D Mario in 2026. This comes from a new podcast published today. It’s claimed that Star Fox will be making a return on Nintendo Switch 2 this summer. Apparently it’ll be a classic...
LA Artisteada podcast’s live ‘Take the Stage’ celebrates female artists
This Sunday, March 29, LA Artisteada, a podcast dedicated to spotlighting a wide range of artistic voices, will host “Take the Stage”, a live event creating space for women of
Engadget Podcast: Can Microsoft fix Windows 11 by dumping AI?
We chat with PCWorld's Mark Hachman about where Windows is headed.
As Kennedy Takes on Food Policy, Companies Push Back
Though the health secretary falsely claimed a victory in a recent podcast, a federal proposal to review all new food ingredients is still in the early stages and drawing fierce opposition.
‘Science Friday’ Host Ira Flatow to Share Health and Wellness Discoveries on April 23
Are ultramarathoners built differently from the rest of us? What can Greenland sharks teach us about aging eyes? As the longtime host of the popular public radio program and podcast Science Friday, Ira Flatow explores questions like these during engaging discussions on topics ranging from science and technology to health, space and the environment.
Award-winning podcasts bring Susquehanna’s stories — and science — to life
Stay up to date with the latest news, stories, and achievements from the Susquehanna University community.
Bloomfield hungry for continued improvement
Oxford United head coach Matt Bloomfield joins the BBC's 72+ EFL podcast to discuss their upturn in Championship form and prospects for the final seven games.
Why Vince Vaughn thinks late-night TV 'stopped being funny'
Vince Vaughn shared his hot take on the state of late-night television during an appearance on Theo Von's "This Past Weekend" podcast.
Ron DeSantis says Sean Hannity helped mend 2018 tiff between Donald Trump, top Florida Republicans over Hurricane Maria
It could have gone very differently had the conservative media icon not persuaded the President to drop a grudge.
Democrats’ long-shot bid to flip Alaska’s Senate seat
Democrats are hoping for an upset in Alaska’s Senate race. U.S. Rep. Mary Peltola, a Democrat, is trying to unseat Republican incumbent Sen. Dan Sullivan. We discuss the major issues at play, plus why Republicans are backing an effort to repeal Alaska’s ranked-choice voting system.This episode: voting correspondent Miles Parks, senior political editor and correspondent Domenico Montanaro, and Alaska Public Media Washington correspondent Liz Ruskin.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye.Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.
Episode 68, Science for Success, Tissue testing and Potassium
By Dusty Sonnenberg, CCA, Field Leader, a project of the Ohio Soybean Council and Soybean Check-off In Episode 68, Dusty visits with soybean researchers involved in the Science for Success program. Science for Success provides timely, cutting-edge best management practices by coordinating the uni
TDN Business Hour: The Global Thoroughbred Market
Mark Taylor, Marshall Gramm, Anthony Trimarchi and Case Clay join the TDN Business Hour podcast hosted by Najja Thompson.
‘Healthy Rounds’: Dealing With Dementia
Dr. Kristina Zdanys, geriatric psychiatrist in the UConn Center on Aging, joins Dr. Anthony Alessi’s podcast
UCLA Health podcast shines a light on colorectal cancer prevention, early detection and rising risks
UCLA Health's podcast episode on colorectal cancer, featuring Dr. Eve Glazier, Katie Couric and Dr. Fola May, highlights the critical need for prevention and early detection amid rising risks, particularly among younger adults. The discussion focuses on cancer screening, lifestyle modifications and advocacy to reduce the incidence of this disease.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Khloé Kardashian Recalls How Her Divorce from Lamar Odom Made Her ‘Obsessed’ with Leading a Healthy Lifestyle
Khloé Kardashian opened up about her relationship with diet and exercise on the March 18 episode of her podcast, ‘Khloé in Wonder Land.’ She said she became ‘obsessed’ with exercise after examining how her food choices were affecting her quality of life.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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No healthcare premiums? In this economy?! Here's how.
It turns out healthcare in America CAN be cheaper. If your employer wants it to be. Today on the show, we speak with a Canadian-founded startup that has unusually generous benefits for their employees. Come see Planet Money live on stage in April! 12 cities. Details and tix here: https://tix.to/pm-book-tour. Related episodes: Health insurance premiums are going up next year — unless you work at these companiesHealth care costs are soaring. Blame insurers, drug companies — and your employerThe hidden costs of healthcare churnFor sponsor-free episodes of The Indicator from Planet Money, subscribe to Planet Money+ via Apple Podcasts or at plus.npr.org. Fact-checking by Sierra Juarez. Music by Drop Electric. Find us: TikTok, Instagram, Facebook, Newsletter.
Global Tensions and Domestic Debates - Inside Politics with Dana Bash and Manu Raju - Podcast on CNN Podcasts
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