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Results for " pixel " 1,067 found 🔀 AI-powered Shuffle

Google Releases Android 17 QPR1 Beta 1 for Pixel

Google surprised us a bit this afternoon with the release of Android 17 QPR1 Beta 1 for its Pixel line-up. This update will come after the first stable build of Android 17 is released, which...

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Apr 22 • 8:28 PM EDT • Technology • droid-life.com
Angry Android users gripe about 'severe' battery drain after latest Google update
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Apr 22 • 2:41 PM EDT • Technology • nypost.com
Google Pixel's battery problems are unforgivable after 10 years

After 10 Pixel generations, five of which have shipped with Google's own Tensor processor, it's unacceptable to see this many battery issues still.

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Apr 22 • 5:30 AM EDT • Technology • androidauthority.com
I was happy with my Pixel camera until I tried the Oppo Find X9 Ultra [Gallery]

While there are a ton of different things I care about on my smartphone, the camera is a huge deciding...

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Apr 21 • 1:25 PM EDT • Technology • 9to5google.com
Oppo announces the Find X9 Ultra with a 50MP 10x optical zoom telephoto camera

The Find X9 Ultra’s main camera is a 200-megapixel sensor. At 1/1.12 inches, Oppo says it’s the largest 200MP sensor in a phone yet, but the 10x optical zoom telephoto may be the star.

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Apr 21 • 1:00 PM EDT • Technology • engadget.com
Pixel phones are seeing unusual battery drain after the latest update — and Google is looking into it

Google has acknowledged the issue and is investigating a fix.

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Apr 21 • 12:11 PM EDT • Technology • androidcentral.com
Vampire Crawlers sees Poncle strike gold again with latest Xbox Game Pass hit

Vampire Crawlers launches into Game Pass today, and after struggling to put down the pixelated dungeon crawler, I'm happy to say it's an big win for Poncle.

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Apr 21 • 10:36 AM EDT • Technology • trueachievements.com
Pixel phones hit with battery drain issue, Google investigating

Following the rollout of the April 2026 update on Google Pixel phones, a widespread battery drain issue has hit, but...

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Apr 21 • 9:40 AM EDT • Technology • 9to5google.com
Pixel 11 is about to get a major glow down

The Pixel 11 may be a spitting image of the Pixel 10, but at least it will glow in the dark.

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Apr 19 • 12:01 PM EDT • Technology • phonearena.com
What do you want Google’s ‘Pixel Glow’ lights to do?

We reported earlier this week that Google is working on a laptop revival, as well as new “Pixel Glow” lights...

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Apr 19 • 12:00 PM EDT • Technology • 9to5google.com
Google is quietly building something that could transform the lineup beyond the Pixel 11

Two words: Pixel Glow.

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Apr 18 • 3:45 PM EDT • Technology • phonearena.com
Pixel Laptop: Return of Google Pixelbook laptops spotted in new OS release

Google continues to add features to Android 17 through its beta program. While many relate to the company's high-end smartphones, Android 17 Beta 4 also contains references to a mysterious new Pixel laptop.

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Apr 18 • 6:07 AM EDT • Technology • notebookcheck.net
A new Android 17 beta reveals plans for “Pixel Glow” light animations.

Google just released the fourth beta for Android 17 today, and now, 9to5Google and Android Authority point out that it contains mentions of a new lighting feature that we might see on the next round of Pixel phones. The Pixel Glow details say it “uses subtle light and color on the back of your device to inform you of important activity when it’s face down,” when interacting with Gemini, or when favorite contacts are calling. [Link: Pixel Glow 'visual feedback' tool might just hint at big Pixel 11 hardware changes | https://www.androidauthority.com/pixel-glow-3658443/ | Android Authority]

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Apr 16 • 7:55 PM EDT • Technology • theverge.com
Google working on Pixel ‘laptop’ and ‘Pixel Glow’ lights that are also coming to phones

Based on the latest Android Canary and Android 17 Beta releases, Google is working on a Pixel “laptop” of some...

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Apr 16 • 6:52 PM EDT • Technology • 9to5google.com
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Pixel Glow 'visual feedback' tool might just hint at big Pixel 11 hardware changes

Is Google bringing rear RGB lights to the Pixel 11 series? References to a "Pixel Glow" tool in Android 17 Beta 4 raise the possibility.

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Apr 16 • 6:32 PM EDT • Technology • androidauthority.com
Android 17 brings a bit of Pixel Watch whimsy to your notification shade

Google is porting over a tidbit from its Pixel Watch to the notification shade on Pixel phones with its Android...

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Apr 16 • 5:10 PM EDT • Technology • 9to5google.com
Here’s everything new in Android 17 Beta 4 [Gallery]

Google today rolled out Android 17 Beta 4 for Pixel devices to continue the preview cycle. This is the last...

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Apr 16 • 4:35 PM EDT • Technology • 9to5google.com
Android 17 Beta 4 rolling out for Pixel as last scheduled release

Google is rolling out Android 17 Beta 4 for Pixel devices three weeks after the last release. This update...

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Apr 16 • 4:10 PM EDT • Technology • 9to5google.com
Google rolls out April Android Canary build with experimental features for Pixel devices

Google has just released the April Android Canary build with new experimental features for Pixel 8 and above.

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Apr 14 • 11:14 PM EDT • Technology • androidauthority.com
Gorgeous Pixel Art Indie Game Arrives Busted On Xbox Series S

Replaced is scoring very well on PC, but the lower-tier Xbox has a game-breaking crash and incomplete ending

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Apr 14 • 10:58 AM EDT • Technology • kotaku.com
GoPro Mission 1 Pro: 8Kp60 Video, 50MP Photos, 10-Bit Log, 5+ Hour Battery

The GoPro Mission 1 Pro features a Type 1 sensor, up to 8Kp60 video capture (along with 8K Open Gate), and 50 megapixel photo capability.

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Apr 14 • 9:00 AM EDT • Technology • petapixel.com
Pixel battery drain issues persist for some, but one user may have cracked the problem

Now we just need Google to fix it

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Apr 14 • 6:29 AM EDT • Technology • androidpolice.com
The Pixel 10 is getting a major security boost you'll never actually see

Google is bringing memory-safe Rust code to the Pixel 10 modem to protect users from remote hacking and memory-safety vulnerabilities.

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Apr 14 • 5:07 AM EDT • Technology • androidauthority.com
Google shoehorned Rust into Pixel 10 modem to make legacy code safer

Cellular modems are complex black boxes of legacy code, but Google is making them safer with Rust.

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Apr 13 • 5:12 PM EDT • Technology • arstechnica.com
New ultra-premium foldable released internationally with big launch discounts

Motorola has now started selling its first book-style foldable. Available internationally, the Razr Fold undercuts the Galaxy Z Fold7 and the Pixel 10 Pro Fold with a massive launch discount and several wearable accessories thrown in for good measure.

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Apr 13 • 12:26 PM EDT • Technology • notebookcheck.net
How to make a high-deductible health plan work for you

An elementary school teacher chose a low-price health insurance plan but soon realized she wasn't clear about what it would mean for her family's finances.

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Apr 13 • 6:36 AM EDT • Health • news-medical.net
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Google’s Latest Pixel Update Is Bad News For Android

Android has a serious problem — and it's now getting worse.

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Apr 13 • 1:48 AM EDT • Technology • forbes.com
Android has a Secret Update Menu You Likely Didn’t Know About

Keeping your Android phone up-to-date should be a straight-forward task. You have updates for apps in the Google Play store and system updates that show up at some point in most... #Apps #Google

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Apr 11 • 1:56 PM EDT • Technology • droid-life.com
Some Google Pixel phones hit with bootloop issues following recent updates, fix in the works

Following some of their latest updates, a number of Google Pixel owners are reporting bootloop issues, with Google “working to...

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Apr 10 • 7:30 AM EDT • Technology • 9to5google.com
Pixel 11 Series to See Big Display Upgrade

Industry sources have confirmed that Google’s upcoming Pixel 11 series will utilize Samsung’s new M16 OLED panels. These are the same panels expected to be used by Apple for its... #Google #Pixel11

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Apr 9 • 5:59 PM EDT • Technology • droid-life.com
Pixel At a Glance preps showing nearby Google Wallet passes, ‘Restaurant insights’

Google is working on two location-based features for the Pixel At a Glance widget with "Passes nearby" and "Restaurant insights."

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Apr 9 • 12:30 PM EDT • Technology • 9to5google.com
Pixel Phone app starts rolling out custom Take a Message greetings

The Pixel’s Take a Message feature that answers calls on your behalf and lets you view live transcripts is now adding custom greetings.

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Apr 9 • 11:24 AM EDT • Technology • 9to5google.com
Google Pixel 11 reportedly gets Samsung’s new flagship display ahead of iPhone

According to a new report, Google’s upcoming Pixel 11 series will be among the first – perhaps even the first...

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Apr 9 • 9:20 AM EDT • Technology • 9to5google.com
Insta360's Nifty New Selfie Screen for Phones Is Now Available Everywhere

Front-facing camera? No thanks!

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Apr 8 • 2:02 PM EDT • Technology • petapixel.com
Google Pixel bests iPhone and Samsung in repairability name-and-shame report

A new report calls out the top smartphone makers in the US for their poor device repairability scores, but Google...

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Apr 8 • 12:45 PM EDT • Technology • 9to5google.com
New Google Photos trick lets you save time while sharing images

Google Photos now supports a new feature that lets you share images more quickly, without downloading the originial first.

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Apr 8 • 6:44 AM EDT • Technology • androidauthority.com
Google’s April 2026 Pixel update tackles some annoying bugs

Fixes game crashes and Quick Share issues

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Apr 8 • 1:07 AM EDT • Technology • androidpolice.com
Android 16 April update rolling out: Pixel UI, app crash fixes

Google is rolling out the April 2026 security patch for Android 16 QPR3 on the Pixel 6, 6 Pro, 6a,...

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Apr 7 • 2:06 PM EDT • Technology • 9to5google.com
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The Best Endorsements Are The Ones You Can't Pay For

We'll probably never know which cameras failed NASA certification and why, but we sure will remember the ones that succeeded.

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Apr 7 • 1:50 PM EDT • Technology • petapixel.com
The MacBook Neo is proof that Google’s Pixel plan was right all along

Apple's MacBook Neo validates the Google Pixel strategy by emphasizing user experience and ecosystem growth over raw hardware benchmarks.

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Apr 7 • 5:00 AM EDT • Technology • androidauthority.com
Google just launched a special-edition Pixel, but you probably can't buy it

The phone celebrates a decade of Google Pixel and introduces exclusive wallpapers alongside custom-themed icons.

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Apr 6 • 10:35 PM EDT • Technology • androidauthority.com
Google Pixel 10a finally launches in Japan with exclusive ‘Isai Blue’ color [Video]

The Pixel 10a launched about a month ago in most of the world, but has been absent in Japan despite...

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Apr 6 • 8:55 PM EDT • Technology • 9to5google.com
The 10-Year-Old Nikon D5 DSLR Really Is the Best Camera for Artemis II

The Nikon D5 may be relatively old, but it's also uniquely powerful in low light.

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Apr 6 • 5:48 PM EDT • Technology • petapixel.com
Pixel 10a after one month: More than the sum of its parts [Video]

The Pixel 10a is a month old, but it's just the Pixel 9a again, right? While that's a fair assumption, but there's more to this phone.

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Apr 6 • 12:00 PM EDT • Technology • 9to5google.com
Google Pixel teases ‘exclusive’ new model, and we might already know what it is

We’re not due for any new Google Pixel phones in the near future, but a surprise teaser has just dropped...

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Apr 6 • 8:55 AM EDT • Technology • 9to5google.com
Google Pixel 10a disassembly nets it a very good repairability score

You can see the whole process in this video. Google launched the Pixel 10a in February and released it in early March, and today a video showing its...

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Apr 6 • 7:44 AM EDT • Technology • gsmarena.com
Samsung Galaxy S26 vs. Google Pixel 10: The Big Differences Between Each Flagship

The most affordable Samsung and Google flagship models are closer than ever, but the $100 price difference does make for a few key differences. Here's how they stack up.

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Apr 5 • 8:00 AM EDT • Technology • cnet.com
The Evolving Role of Technology vs Skill in Wildlife Photography

I increasingly find myself reflecting on the balance between technological advancement and genuine photographic skill.

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Apr 5 • 7:01 AM EDT • Technology • petapixel.com
Is Brain Health the Next Healthcare Frontier?

Arianna Huffington breaks down the impact of daily behaviors on brain health.

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Apr 3 • 6:00 AM EDT • Health • time.com
This Android feature could put your notifications on autopilot

Create rules to filter alerts

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Apr 3 • 12:55 AM EDT • Technology • androidpolice.com
Pixlel 11 Pro XL renders show Google going all-in with new camera bar

Pixel 11 Pro XL renders complete our preview of this year's non-foldable models.

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Apr 2 • 10:13 AM EDT • Technology • androidauthority.com
Exclusive: Google Pixel 11 Pro XL Official CAD Renders & Rumors

After showing off the Pixel 11 and Pixel 11 Pro earlier this week, let's end the week on a high note with the Pixel 11 Pro XL. As expected, the Pixel 11

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Apr 2 • 10:02 AM EDT • Technology • androidheadlines.com
Google creates confusion with a "new" Wear OS 6.1 update

Google's developer docs list "new" Wear OS 6.1 features, including time zone detection, despite the update launching in late 2025.

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Apr 2 • 5:24 AM EDT • Technology • androidauthority.com
Google Hints at a New Fitness Health Wearable, Hidden in a Steph Curry Video

Looks like Google's Fitbit and Pixel smartwatches might be getting a new sibling.

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Mar 31 • 6:51 PM EDT • Health • cnet.com
Google may put another annoying limitation on Pixel 10 users with an upcoming update

Tinkering with your Pixel 10 could become more difficult with a Google software update.

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Mar 31 • 3:12 PM EDT • Technology • phonearena.com
Google Photos is losing some of its editing shortcuts to ‘reduce accidental triggers’

Google Photos is dropping some of its editing shortcuts in order to streamline the app experience for those looking for simpler edits.

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Mar 31 • 2:45 PM EDT • Technology • 9to5google.com
Pixel 11 Pro leaks with the all-glass camera bar and thinner body, but same design [Gallery]

Right on schedule following yesterday’s Pixel 11 leak, the Pixel 11 Pro has shown up in leaked renders that show...

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Mar 31 • 11:05 AM EDT • Technology • 9to5google.com
Exclusive: Google Pixel 11 Pro Official CAD Renders & Rumors

The Google Pixel 11 Pro is set to debut later this summer, alongside the Google Pixel 11 which we leaked yesterday. The design is staying basically the

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Mar 31 • 10:00 AM EDT • Technology • androidheadlines.com
Android's new developer verification rollout begins, sideloading changes are next

Google says the new advanced sideloading flow will launch in August, followed by a wider global rollout.

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Mar 30 • 11:37 PM EDT • Technology • androidauthority.com
Early Pixel 11 renders highlight a big camera island change

Goodbye, table wobble

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Mar 30 • 12:23 PM EDT • Technology • androidpolice.com
Google Pixel rolls out ‘Transit mode’ and real-time At a Glance commute

Google is now rolling out Pixel Transit mode to “turn on helpful settings while you’re on the train” and commute updates in At a Glance.

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Mar 30 • 11:57 AM EDT • Technology • 9to5google.com
The latest Pixel 11 leak shows slimmer bezels and an all-black camera bar

The Pixel 11 may have a couple of design tweaks in store.

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Mar 30 • 11:52 AM EDT • Technology • theverge.com
Report: Series Entertainment subsidiary Pixelberry lays off staff

Series Entertainment-owned mobile dev Pixelberry Studios, known for Choices, has reportedly laid off staff for the second time in two years.

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Mar 30 • 11:21 AM EDT • Entertainment • gamedeveloper.com
Google Pixel 11 looks like another minor evolution in leak, slightly thinner [Gallery]

If you were expecting a big redesign for Google's Pixel anniversary this year, these Pixel 11 leaks might disappoint.

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Mar 30 • 11:01 AM EDT • Technology • 9to5google.com
Exclusive: Google Pixel 11 Official CAD Renders & Rumors

The Google Pixel 11 is set to be released later this Summer, a bit later than the Galaxy Z Fold 8 and Galaxy Z Fold 8 Wide, which we leaked last week.

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Mar 30 • 10:00 AM EDT • Technology • androidheadlines.com
One of March's best Pixel features is finally reaching more users

Transit mode and commute notifications are finally rolling out widely.

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Mar 30 • 5:33 AM EDT • Technology • androidauthority.com
The Pixel 10a doesn't have a camera bump, and it's great

The Google Pixel 10a can lay flat on a table, but otherwise the company hasn't brought a ton of upgrades to its newest budget smartphone.

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Mar 29 • 5:30 PM EDT • Technology • techcrunch.com
Sony Shuts Down Nearly Its Entire Memory Card Business Due to SSD Shortage

Sony has announced that it is suspending fulfillment of all orders for nearly its entire SD and CFexpress memory card product lines.

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Mar 27 • 12:41 PM EDT • Technology • petapixel.com
Sony Shuts Down Nearly Its Entire Memory Card Business Due to SSD Shortage

Sony has announced that it is suspending fulfillment of all orders for nearly its entire SD and CFexpress memory card product lines.

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Mar 27 • 12:41 PM EDT • Business • petapixel.com
Finally! Single-tap Wi-Fi control returns to Quick Settings in Android 17 Beta 3

Android 17 Beta 3 just made managing your Wi-Fi connection one tap simpler.

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Mar 27 • 11:45 AM EDT • Technology • androidauthority.com
Android 17 Beta 3 reveals Google may be testing a smarter charging feature (APK teardown)

Called 'Priority Charging,' the feature pauses background activity to speed up charging.

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Mar 26 • 11:34 PM EDT • Technology • androidauthority.com
Google rolling out Android 17 Beta 3 for Pixel

Just under three weeks after the last release, Google is rolling out Android 17 Beta 3 for Pixel devices. This update features...

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Mar 26 • 4:00 PM EDT • Technology • 9to5google.com
The DJI Avata 360 Aims to Ground Insta360's Drone Dreams

With a better camera, more advanced sensors, and more versatility, DJI is clearly aiming to take down Insta360’s Antigravity.

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Mar 26 • 8:00 AM EDT • Technology • petapixel.com
Apple Testing 200MP iPhone Camera That Could Ship Next Year

Apple is evaluating a 200-megapixel telephoto camera sensor that could potentially ship in an iPhone as soon as next year, according to Digital Chat Station, a leaker on Chinese social media platform Weibo with a decent track record. In a post shared today, the leaker said Apple is actively testing a 200-megapixel 1/1.2" sensor similar to the one rumored for Oppo's upcoming Find X9 Ultra.

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Mar 26 • 7:04 AM EDT • Technology • macrumors.com
Samsung price hikes on Galaxy A37, A57 start at $449, make Pixel 10a worth a look

Samsung just announced its new mid-range Galaxy A37 and Galaxy A57 phones and they’re coming to the US, but with...

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Mar 25 • 2:05 PM EDT • Technology • 9to5google.com
Google confirms Android Auto fixes for Pixel, Galaxy users facing connection problems

Some Google Pixel and Samsung Galaxy users have been running into problems with Android Auto as of late, but fixes...

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Mar 25 • 10:15 AM EDT • Technology • 9to5google.com
Google says Pixel Watch step counts and other stats are fixed, but your data won’t be

Following a few days where Pixel Watch owners would run into wonky step counts and other stats, Google says the...

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Mar 24 • 11:40 AM EDT • Technology • 9to5google.com
'Claude, Resize These Photos' - Anthropic's Agentic AI Will Run Photoshop For You

It can perform boring tasks.

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Mar 24 • 5:46 AM EDT • Technology • petapixel.com
Android Auto is breaking for Pixel and Samsung users, and no one knows why

Users are reporting connection issues associated with a recent update and an Android 16 security feature.

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Mar 23 • 11:36 PM EDT • Technology • androidauthority.com
Google’s new Pixel 10 ads made me go ‘wait, WHAT are they trying to sell?’

Confusing and a bit creepy.

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Mar 23 • 3:49 PM EDT • Technology • theverge.com
Samsung's Galaxy S26 will get Apple AirDrop support starting today

The feature was first launched on Pixel 10 phones last year.

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Mar 23 • 7:04 AM EDT • Technology • engadget.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
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Android's new desktop windowing mode has changed how I use my tablet

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Deals: Galaxy S26 series now available, S25 and Pixel 10 models on sale

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NATIONAL WOMEN’S SOCCER LEAGUE AND FRONT OFFICE SPORTS ANNOUNCE CONTENT PARTNERSHIP | News

FOS to showcase NWSL's signature events and moments, including 2026 NWSL Championship, presented Google Pixel, through business focused storytelling

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Mar 12 • 8:01 AM EDT • Sports • nwslsoccer.com
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Built around your commute

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