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The dangers behind health 'maxxing'
"Maxxing" is a way of promoting extreme ways to optimize physical and mental health.
Scientists finally explain what turns a storm into a super typhoon - Futura-Sciences
That kind of runaway strengthening looks almost supernatural, but it follows clear physical rules. So what actually turns an ordinary storm into a super typhoon, and why does it seem to happen faster than it used to? An engine fueled by warm water A typhoon, which is simply what a...
Do data centers impact our physical health? Studies are few and far between.
There research into physical health impacts related to data centers is still in its early stages, but seems comparable to other industries.
Fast walkers in their 80s cut their risk of cognitive decline by half, study finds
A new study of people 80 and older with exceptional gaits finds fast walkers have about a 50% lower risk of cognitive decline, showing the connection between physical health and brain health.
Halo: Campaign Evolved’s boxed version will come with physical discs so that players can ‘have tangible items to add to your collection’
The news comes after two major blows to physical game collectors…
Autographed Sports Memorabilia Trends 2026: The Players and Items Worth Chasing This Summer
Today in this blog on Athlon Sports, we will discuss autographed sports memorabilia trends 2026 and the top assets this summer. Dedicated hobbyists are driving immense liquidity into physical assets right now. Tracking major roster shifts yields great results.
Real Madrid forward Rodrygo delivers hopeful recovery update
Physical issues and injuries suffered by their players has been one of the most significant problems that Real Madrid have faced in the last few years, and this problem has undoubtedly played a role i...
Metal Gear Creator Responds To Sony Killing PlayStation Discs
The Death Stranding 2 director warns about a world without physical media
PS5 Bug Removes Playtime Tracker from Physical Games Only
Likely a glitch that will be fixed
Gamers push back: 71% say they’re not ready to let physical games die as PlayStation and Xbox move toward a digital-only future”
Our community has spoken, and 71% say physical games still matter. Here's why ownership and consumer choice remain major concerns.
A career of flying for science (and the occasional sled dog)
Martin Stuefer, the director of the Hyperspectral Imaging Lab at the University of Alaska Fairbanks Geophysical Institute, is both a pilot and researcher.
After Sony Kills PS5 Discs and GTA 6 is Just a Code in a Box, Xbox Is Using Halo: Campaign Evolved's Physical Disc as a Selling Point
Microsoft is using the fact that Halo: Campaign Evolved will offer a physical game disc in its box as a selling point.
"We are profoundly disappointed by Sony's decision" – Game companies express dismay at the end of PlayStation disc production
Atari, Iam8bit, Lost in Cult, and Silver Linings Interactive are among the firms lamenting the loss of physical games
Sony has already started repurposing its lone PlayStation disc factory, and the body of physical gaming isn't even cold
The Sony disc-making operation is already planning to retrain its 300 employees to make microlenses.
Patient Care Center structure changing for physical medicine and rehabilitation
The changes align with Vanderbilt Health’s strategic vision for growth, including regional expansion and the development of innovative rehabilitation and pain medicine services.
Dune: Awakening ‘Deep Dive: September 2026 Preview’ video, PS5 physical edition announced
Funcom has released a new “Deep Dive” video for open-world survival game Dune: Awakening ahead of its upcoming consoles launch, as well as announced that a physical edition will be avai…
How Xbox's 'Disc-2-Digital' plan is going to work, according to tester reports
Xbox is currently testing a new 'Disc-2-Digital' feature that will add your physical Xbox games to your digital library, and we now know how it's going to work.
"PS5 Will Be My Last Console": After 45K Votes, 86% of DF Viewers Say Sony Should Reconsider Killing Physical Games
That's just under 40,000 people writing in to oppose Sony's plans.
The new presidential fitness test is a positive step, not the solution, experts say
Physical activity needs to be fun to keep kids engaged. And the test risks embarrassing them, instead.
Bowles Extremely Impressed With 1 Quality of Rueben Bain Jr.
Defying concerns over his physical reach, the rookie edge rusher is wielding veteran-level intelligence to ignite Tampa Bay’s pass rush and solve a long-standing defensive drought.
Sony is first console giant to stop making physical games
Move sparks angry response from some gamers
Bethesda Shows Off Oblivion Remastered Switch 2 Physical Release
"I knew I could count on you"
Bethesda Makes Clever Oblivion 'Physical' Post As Sony Scraps Discs
Bethesda Game Studios has made a post on social media that seems to be poking some kind of fun at Sony's recent PlayStation disc news.
Xbox is reportedly considering dropping disc drives as it tests new feature that lets players digitize physical games
A new report now claims Xbox, like PlayStation, is set to "drop the disc drive."
Sony will stop making physical copies of PlayStation games in 2028
“We will own nothing, it's truly sad.”...
Sony to end physical PlayStation game discs for new releases starting in 2028
Sony says all new PlayStation games released after January 2028 will be sold digitally, reflecting changing consumer demand and the gaming industry's broader move away from physical media.
Xbox testing disc-to-digital feature that digitizes a physical game collection
Microsoft’s disc-to-digital feature could be essential for next-gen Xbox consoles.
You won’t be able to buy new PlayStation games on discs starting in 2028
It's is a massive step toward the dissolution of physical media in games, since PlayStation holds the biggest share of the console market.
Apple’s iPhone 18 Pro Max eSIM Model To Pack A Mammoth 5,425mAh Battery, While Physical SIM Buyers Get Predictably Shortchanged On Battery Capacity
In keeping with the prevailing divulgatory trend, the latest tidbit has detailed the battery capacity within Apple's iPhone 18 Pro Max.
Sony says goodbye to discs for new PlayStation games in 2028
Sony said it will stop production of physical discs for PlayStation games in response to industry and consumer shifts.
Sony PlayStation Phasing Out Physical Video Game Discs
Sony PlayStation said it plans to end production of physical video game discs by January 2028.
The Supreme Court’s trans sports ban ruling is about exclusion, not safety, advocates say
The Supreme Court can't stop using biological arguments to advance bigotry. In a 6-3 ruling, the justices sided in favor of state laws that ban transgender athletes from women's sports teams, citing unfair competition and physical danger.
Sony is killing all physical PlayStation game discs
New games released after January 2028 will be digital-only.
Sony will cease production of discs for new PlayStation games in 2028
New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?
Scientists recreated a dinosaur nest and solved a 70-million-year-old mystery
A team of researchers recreated a life-size oviraptor nest to investigate how these bird-like dinosaurs incubated their eggs millions of years ago. By combining physical experiments with heat transfer simulations, they discovered that oviraptors likely relied on both their own body heat and warmth from the sun.
Physical disc production ending in January 2028 for new games releasing on PlayStation consoles
In response to shifting trends in consumer preference, new games will be released on PlayStation Store and at retailers in digital formats only.
North Dakota opens wellness equipment funding opportunity for rural hospitals | Health and Human Services North Dakota
From fitness and recovery equipment to mindfulness tools and wellness spaces that help reduce burnout, North Dakota Health and Human Services (HHS) is investing in the health and well-being of rural healthcare workers through a new funding opportunity for rural hospitals.Applications are now open for the Hospital Wellness Equipment funding opportunity through the North Dakota Rural Health Transformation Program (RHTP), providing resources to help rural North Dakota hospitals create healthier workplaces and support the physical, mental and emotional well-being of their workforce.
America's national parks could add years to your life — here's how they boost health
National parks offer more than scenic views. Research shows trails and greenways boost physical activity, reduce stress and improve mental health.
The Elder Scrolls IV: Oblivion Remastered for Switch 2 launches August 11
The Switch 2 version of The Elder Scrolls IV: Oblivion Remastered will launch on August 11, publisher Bethesda Softworks and developer Bethesda Game Studios announced. Pre-orders for the physical e…
VA Primary Care adds virtual reality to Veterans’ Mental Health Toolkit
Virtual reality devices help Veterans by offering additional ways to manage issues affecting their physical and mental health.
The Elder Scrolls 4: Oblivion reveals Nintendo Switch 2 physical release with full game on cartridge
There’s finally some news about the upcoming Nintendo Switch 2 version of The Elder Scrolls 4: Oblivion, as a physical release has now been revealed. To clarify, this is a true physical version with the game on the cartridge. It will not be a game-key card, which has drawn ire from collectors. The news about the physical version of The...
Disastrous GTA 6 Pre-Order Numbers Revealed By Store Staff
GTA 6 pre-orders opened last Thursday and it is speculated millions, potentially tens of millions of people, have already parted ways with $70 to $100 ahead of launch. However, physical sales of t…
'I used to feel physically sick
Former road racer Keith Amor admits he misses the thrill of competing at the Isle of Man TT, he tells the BBC Bikes podcast.
'Staying away from the middle will be hardest': Sachin Tendulkar's emotional message to Ben Stokes after retirement
Sachin Tendulkar led heartfelt tributes to Ben Stokes following his retirement from international cricket. Tendulkar lauded Stokes' fearless approach, match-winning ability, and inspirational leadership, calling him one of England's finest all-rounders and captains. Stokes, who bowed out after a Test series loss, expressed contentment with his decision, citing years of physical and mental demands as the primary reason for stepping away.
Sword Health contracted to provide AI-supported physical therapy for an entire country
Portugal's National Health Service signed a deal with digital health company Sword for its AI-assisted virtual physical therapy care.
Multiple sclerosis affects social life and work beyond physical health
Multiple sclerosis (MS) can have a substantial impact on many aspects of life beyond physical health, with 51% of people reporting that the disease affects their social life and 48% reporting that it affects their work, according to new research presented at the European Academy of Neurology (EAN) Congress 2026.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Jimmie Williams could be Ohio State’s most important transfer addition
After averaging more than 15 points per game at Duquesne, Jimmie Williams brings physical scoring, positional versatility, and the dependable bench offense Ohio State has lacked in recent seasons.
Sony’s New Blu-ray & DVD Player Upscales DVDs to Near-HD Quality - Bring Your Old DVDs To Life Again
In a time when streaming services continue to raise prices, fragment content libraries, remove content, and push intrusive ads, many households are rediscovering the reliability and ownership of physical DVDs and Blu-rays. Sony has answered this shift with the release of its latest affordable disc player: the Sony BDP-S1700U. Priced at just $114.99, this sleek […]
Important Penn State prospect makes notable physical transformation
Penn State star Max Granville’s career has been stunted by injuries so far, but his body transformation is sure to excite fans.
How ‘exercise snacks’ can improve your health
Doctors say short bursts of physical activity can improve your health. Here’s how to make these “exercise snacks” count.
Habs Daily: Canadiens Draft Picks, Focus On Physicality, Trades
Here are the Montreal Canadiens and NHL news items you may have missed on a very busy NHL Draft weekend. […]
GTA 6 could be the final death knell for physical media
But you can always collect empty boxes.
Former NFL star Warrick Dunn hosts wellness day with health screenings, financial education
Saturday’s event was centered around improving physical health, financial stability, and mental well-being.
GTA 6 has no plans for a post-launch physical release, "not at launch, and not months later", insists new report
A new report has cast doubt on news that a physical version of Grand Theft Auto 6 will follow the digital release later this year after all.
Dear Abby | Mom's rekindling with abusive father feels like a betrayal
Dear Abby: I am estranged from my father and have been since I was 12. (I'm currently 26.) He was emotionally, psychologically and physically abusive to me, and cutting ties
ON Semi tanks 20% following Synaptics deal as CEO defends core business
The pivot into physical AI grows On Semi's addressable market by an additional $30 billion, the company said.
Notre Dame 2026 Player Profile: Wide Receiver Devin Fitzgerald
As the son of an NFL legend, this physical Arizona standout is already flashing elite route-running and contested-catch skills after a dominant spring debut in South Bend.
Digital-Only 'Grand Theft Auto VI' Is a Car Crash for Physical Media
Not all progress is progress.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Cheshire orchard closes after 75 years in business
A longtime Cheshire orchard has announced its closing for good. In a message shared with customers, the family that owns Drazen Orchards said it is now permanently closed and will not reopen for the foreseeable future. The orchard has been open since 1951. The Drazen family said the decision was difficult, citing rising operating costs, the physical demands of running…
Grand Theft Auto VI pre-orders open, but don’t expect a physical copy
The blockbuster launch is expected to dwarf the box office takings of the year’s biggest movies with one industry analyst predicting it could make $1bn within an hour
Moody Center announces exhibition exploring math, science and tech rooted in Indigenous knowledge systems
Through a framing of North, Central and South America as interconnected regions, “Radiant Geometries: Vectors of Knowledge from the Indigenous Americas” brings together contemporary Indigenous and Latin American artists whose practices illuminate knowledge as a living technology, through which the mathematical, metaphysical and artistic realms converge.
Imaging-related burdens may be keeping some from completing cancer screenings
Targeted interventions could help reduce pre-test anxiety, improve the physical screening experience, and address structural barriers in underserved settings.
Grand Theft Auto VI will cost $80 without a physical disc
GTA6 might be an outlier, though—at least for now.
GTA VI is a worrying sign for the future of physical games
Your GTA VI box will have a download code, but not a disc.
SouthCoast offering sports physical clinic
Physicals required for all student-athletes in Georgia
Men’s Health: Caring for the Body, Mind and Spirit
FORT POLK, La. — Seeking help is often viewed as a vulnerability in military culture, but healthcare providers at Bayne-Jones Army Community Hospital are reframing it as a tactical strength. In observance of Men's Health Month, a BJACH family physician, a mental health provider and the hospital chaplain have partnered to deliver a unified message: peak military readiness requires actively maintaining the body, mind and spirit. From utilizing routine screenings to leveraging physical discipline to build mental resilience and cultivating a strong spiritual community, the team outlines actionable steps to overcome the physical, emotional and isolation barriers that uniquely impact men.
GTA 6 price of $80 revealed and 'physical' edition will contain no disc
Rockstar has said physical copies of the game will contain a code for a digital download for the game.
iOS 27 Wallet App Gets 7 New Features
Apple is making more of an effort to turn the iPhone into a physical wallet replacement in iOS 27, and there are several upgrades to the Wallet app. Pass Upgrades Apple upgraded airline boarding passes in the Wallet app with iOS 26, and in iOS 27, upgrades are coming to additional types of passes.
Kaiser doctor talks about importance of routine check-ups for men’s health
June is Men's Health Month, which is aimed at encouraging men to focus on their physical and mental well-being. Kaiser Permanente’s Dr. Angel Mendoza-Gonzalez joined KCRA 3 on Tuesday to talk about men’s health issues.
Sonic Frontiers: Definitive Edition now available for Switch 2
SEGA has released Sonic Frontiers: Definitive Edition for Switch 2 for $49.99. It is available digitally, as well as physically as a game-key card.
Bed Bath & Beyond reopens in Washington
After filing for bankruptcy and closing all its physical stores in 2023, Bed Bath & Beyond will return to Bellevue as part of a partnership with The Container Store.
STRIKE FIGHTER LEAGUE ENTERS THE SPORTS ENTERTAINMENT ARENA AS WORLD'S FIRST PROFESSIONAL AIR COMBAT SPORT
/PRNewswire/ -- Strike Fighter League (SFL) is the world's first professional air combat digital sport that combines elite human performance and physical...
No. 1 Mistake People Make When Buying Walking Shoes That Harms Foot Health
In TODAY.com’s Expert Tip of the Day, a physical therapist reveals a common mistake people make when choosing walking shoes and how to fix it for better foot health.
Finnish scientist Wickström awarded Körber Prize for cell research
Finnish researcher Sara Wickström has been awarded the Körber European Science Prize for discovering that cells sense physical forces, a finding that might open new possibilities for the treatment of ...
Princeton joins powerhouse network for theoretical physics with major gift from the Leinweber Foundation
With this gift, Princeton will become the ninth member of the Leinweber network for theoretical physics, which is focused on advancing curiosity-driven research on the theoretical principles underlying the physical universe.
Butterfly that barely ages could help unlock longevity secrets
Scientists discovered that Heliconius butterflies have evolved an extraordinary lifespan, living several times longer than closely related species. Even more surprising, some show little sign of physical decline as they age. Their unusual pollen-feeding lifestyle may play a role, but the research suggests deeper evolutionary changes are also helping them stay healthy for longer.
MASTER CLASS: Tap in to the power within to make healthy choices
Intention is a very powerful psychological attribute contributing toward any behavior change. Without an intent to change, there's almost zero chance it will occur – especially with respect to health behaviors. This week, I'll present some tips for maximizing intention in an effort to make good behaviors "stick." Plus, I'll introduce an exercise that fits perfectly into physical activity program.
Scientists discover neurons must break their DNA to build the brain
As newborn neurons make their way through the developing brain, they must squeeze through incredibly tight spaces to reach their final destinations. Researchers discovered that this physical journey routinely causes some of the most severe forms of DNA damage—double-strand breaks—yet the young brain has evolved an impressive ability to repair the damage almost immediately.
Move with the mayor: Buffalo kicks off community health walk at Delaware Park
Mayor Sean Ryan joined residents Saturday morning for the "Move with the Mayor" event at Delaware Park, which is aimed at encouraging physical activity and breaking down barriers to good health.
Sumter Men’s Health Fair aims to connect men with physical, mental, and social wellness resources
A free community health fair in Sumter is taking a holistic approach to men’s wellness by bringing physical health, mental health, and social well-being resources together in one place.
Reframing exercise: How simple physical activity boosts health | Harvard T.H. Chan School of Public Health
For many people, consistent exercise feels daunting — an all-or-nothing proposition in which setbacks signal failure and advice overwhelms. This discussion reframes physical activity as something accessible and sustainable by challenging common myths about exercise.
The unwanted return of tetanus; why soccer makes people so happy; breast cancer in men; plus other stories with Vanderbilt Health sources
Women’s Health interviewed Kathryn Edwards, MD, Sarah H. Sell and Cornelius Vanderbilt Professor of Pediatrics, for a story about her JAMA Viewpoint article on tetanus making a comeback. Women’s Health interviewed Colin Armstrong, PhD, Assistant Professor of Clinical Psychiatry and Behavioral Sciences and Assistant Professor of Physical Medicine and Rehabilitation, for a story tied to the World Cup about why soccer makes people so happy. An NBC News story about the announcement by “X-Men” actor and former wrestler Tyler Mane that he has breast cancer quotes Ben Ho Park, MD, director of the Vanderbilt-Ingram Cancer Center. The story focuses on how a prominent man with breast cancer may help remove some stigma from a cancer that is rare in males. Prevention magazine interviewed Caitlyn Mooney, MD, Assistant Professor, Department of Orthopaedic Surgery, for a story about a BMJ study that suggests 90 to 120 minutes per week of strength training may lower the risk of death. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (norovirus is more common this summer); SFGate (measles in San Francisco just before the World Cup crowds); Travel + Leisure (how to avoid getting sick on a cruise); and Fox News (mosquito-borne diseases). Reporter Liz DeSantis from WKRN News 2 aired a story on the rehab unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt. Kat Hedden, PT, DPT, PCS, CBIS, Acute Pediatric Physical Therapy Clinical Team Lead and Mary McLanahan, MD, Assistant Professor of Physical Medicine and Rehabilitation were interviewed, as well as the family of patient Will Terry. Reporter Nikki Hauser from WTVF News Channel 5 interviewed Graden Knapp, Gaming and Technology Specialist at Monroe Carell Jr. Children’s Hospital at Vanderbilt about his 3-D wheelchair project. Tennesseanreporter Sandy Mazza covered the announcement of the latest Leadership Nashville class, which includes Jane Freedman, MD, Deputy CEO, and Chief Health Systems Office for Vanderbilt Health; and also the announcement of the latest Leadership Tennessee cohort, which includes Jeff Upperman, MD, Surgeon in Chief at Monroe Carroll Jr Children’s Hospital at Vanderbilt.
My Hero Academia: All’s Justice coming to Switch 2 on September 3 in Japan, September 4 worldwide
Publisher Bandai Namco and developer Byking will release My Hero Academia: All’s Justice for Switch 2 on September 3 in Japan and September 4 worldwide, the companies announced. The physical …
Essentia Health-Casselton Clinic to offer sports physical and immunization blitzes
Essentia Health will offer sports physical and immunization blitzes to area students in preparation for the 2026-27 school year.
Essentia Health-Casselton Clinic to offer sports physical and immunization blitzes
Essentia Health will offer sports physical and immunization blitzes to area students in preparation for the 2026-27 school year.
Ozempic users may be making a major weight-loss mistake, new study suggests
New research finds GLP-1 users significantly reduced physical activity, with daily steps and exercise declining after starting a weight loss medication.
Burke High School hosts second annual free sports physical clinic
For the second year in a row, many student athletes got an extensive sports physical exam for free at Burke High School.
Chautauqua County Announces Funding Opportunity for Youth Sports Programs
MAYVILLE, N.Y. — The Chautauqua County Youth Bureau is looking to expand opportunities for young people to experience the many benefits of youth sports, including teamwork, leadership, physical activity and personal growth.
WNBA power rankings: Who’s struggling most with the league’s new whistle
The league has placed an emphasis on freedom of movement to address growing physicality and some teams have adapted better than others.
'Sopranos' star Joe Pantoliano shares his unconventional recipe for optimal mental health
Joe Pantoliano revealed his three secret weapons for mental and physical health while discussing addiction: masturbation, medication and meditation.
This $60 Retro Gaming Device Saved My Childhood Final Fantasy III Endgame Save From The Slow Demise of Cartridge Battery Death
Preserve your physical Super Nintendo library and save files forever. We tested the Epilogue SN Operator to see if this $60 device is a must-have for SNES collectors.
👀 Spain wait on Lamine, can he play this afternoon?
The Spanish national team begins its World Cup campaign this afternoon (18:00 CET) against Cape Verde. The big question surrounding the starting eleven is the physical condition of La Roja’s young s...
Mind, Body, Soul: Self-Care Is Health care Community Health Day
Ethan Temple Seventh-day Adventist Church invites residents throughout the Miami Valley and surrounding communities to attend its “Mind, Body, Soul: Self-Care Is Healthcare: Community Health Day” on Saturday, July 25, 2026, at Ethan Temple SDA Church, 4000 Shiloh Springs Road, Clayton, Ohio 45315.The free community event is designed to promote holistic wellness by addressing physical, mental, emotional, and spiritual health while connecting individuals and families with valuable healthcare and community resources.The day opens with Morning Worship at 11:00 a.m., featuring guest speaker Alberta Scruggs, a licensed registered dietitian and nutritionist, who will share practical guidance on nutrition, self-care, and healthy living. Following the service, attendees will enjoy refreshments and a light lunch before taking part in the afternoon's health screenings, community resource fair, and wellness-focused activities.From 2:00 p.m. to 5:00 p.m., attendees will have access to free health screenings provided through a partnership with Premier Health, along with information and resources from local health and human service organizations.A Community Health Fair from 2:00 p.m. to 3:30 p.m. will feature representatives from several organizations such as Black Women’s Health Initiative, CareSource, and many more.Recognizing the growing importance of emotional wellness, the event will also feature a Mental Health Panel Discussion from 3:30 p.m. to 5:30 p.m. led by respected professionals in behavioral health and counseling. The panel will provide an opportunity for open conversation, education, and community engagement around mental health awareness, treatment, and support.In addition to health services and educational opportunities, attendees will receive complimentary lunch bags while supplies last, and school supplies will be distributed to students and families while supplies last.The Community Health Day is open to the public and free of charge. No registration is required.
Community wellbeing programme launches in Truro for residents
Sessions will focus on areas including physical health, emotional wellbeing and stress management.