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Linden Entertainment Signs ‘Your Friends & Neighbors’, ‘Tow’ Director Stephanie Laing
EXCLUSIVE: Linden Entertainment has signed Emmy-winning director, writer, and producer Stephanie Laing for management. Laing is coming off the theatrical release of her new film, Tow, a comedy-drama s...
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Neighbors say Indian Springs revival could do KCK ‘more good than that stadium’
Area businesses said they want to see the project revitalize the State Avenue business corridor near I-635.
Something extremely weird is happening to our galactic neighbor. Scientists think they know why
The stars in the Small Magellanic Cloud aren’t behaving the way they should. A cataclysmic collision with another nearby galaxy may be the culprit
Nextdoor Promotes Tony Castellanos to Executive Vice President, People as AI-Driven People Strategy Becomes Core to Business Growth
SAN FRANCISCO, March 19, 2026--Nextdoor Holdings, Inc. (NYSE: NXDR), the essential neighborhood network, today announced the promotion of Tony Castellanos to Executive Vice President, People. Castellanos will lead Nextdoor's People organization — including talent acquisition, compensation, HR business partnering, and benefits — as the company deepens its investment in AI-enabled People operations and continues to scale its workforce strategy.
Dickens calls on business community to help tackle neighborhood disparities
In his State of the City address, the mayor urged businesses to "say yes" and help invest in underserved areas.
Cleveland business owner pushes back on illegal burning concerns after years of complaints
A Cleveland business owner is defending himself after neighbors raised concerns about suspected illegal burning on his property.The concerns first surfaced afte
5 Portland sports bars where you can watch every wild March Madness moment this year
From an early-bird option near the Moda Center to a neighborhood spot devoted to women's sports, these Portland bars offer full menus and multiple TVs for tournament viewing.
Koreatown rideshare driver arrested for allegedly using $2M in COVID business loans for crypto investment
A rideshare driver from Los Angeles’ Koreatown neighborhood has been arrested for allegedly using more than $2 million in fraudulently obtained COVID-19 pandemic business loans to buy cryptocurrenc…
After a decade in Titusville, this neighborhood restaurant now closed
Ice House Grill, a longtime restaurant along U.S. 1 in Titusville, has closed after 10 years in business at 2850 S. Washington Ave.
Paul Questions Mullin’s Character Over Response to Attack by Neighbor
Senator Rand Paul was assaulted in 2017. Markwayne Mullin acknowledged that he once said he understood the reason for the attack, but did not apologize.
At least 9 Sacramento businesses hit by overnight burglaries
Sacramento police are investigating at least nine overnight burglaries across Curtis Park and Lemon Hill neighborhoods, with surveillance footage capturing thieves in action.
Geffen Playhouse 2026-27 season: world and L.A. premieres
Geffen Playhouse Artistic Director Tarell Alvin McCraney aims to deliver 'world-class theater at your friendly neighborhood playhouse.'
Deadline Hollywood
CBS and Entertainment Tonight are saying goodbye to The Neighborhood with a farewell special. Read more below.
What's being built on Route 13 south of Smyrna, near Garrisons Lake?
A 9,100-square-foot building is under construction between Economy Inn and the Spring Meadow neighborhood.
U.S. completes historic hockey sweep in Olympics, Paralympics
Three weeks after the United States beat Canada in the Olympic hockey finals, the Americans overcame their neighbors again to win Paralympic gold and complete the three-peat at Milan Cortina.
Iran wages economic war in hopes of outlasting U.S. and Israel
Tehran warns of strikes on banks after hitting data centers, hotels, airports and seaports, threatening the global finance hub of its more prosperous neighbors.
As the risk of measles grows, why are parents so divided on vaccines?
In South Carolina, some parents embrace vaccines, others opt out. Why do people make such different choices? A mix of politics, distrust and misinformation is pushing neighbors apart.
Chapel Hill's South Creek Neighborhood Celebrates Construction Milestone, Announces First Business Tenant
The South Creek neighborhood's development team gathered for a ceremony recognizing the completion of its first full building structure.
Bucksport grocer who expanded business to neighboring counties dies at 73
Grocer Dale Tozier Sr., who expanded his family's grocery business in Maine, remembered as a community-focused family man.
The Neighborhood Politics of a Massive Home Addition
As municipalities encourage more housing density, neighbors debate what kind of construction should be allowed.
Business owners helping shape Hertel Avenue during Women’s History Month
BUFFALO, N.Y. (WIVB) — March is Women’s History Month, a time to recognize the contributions women have made in communities across the country. On Hertel Avenue in Buffalo, many of the neighborhood…
Cancer Haunts Neighbors of Canada’s Oil Sands Wastelands
Though high rates of the disease persist among the nearby Indigenous communities, the Canadian government is weighing rules that may allow energy giants to release treated mining waste into the river system.
Community chips in to help business damaged by building collapse
The building has sat empty since the 1980's, but over the weekend, part of the for 5 and 10 in Wellsville collapsed onto a neighboring business in the 400 block
Clermont’s plan to protect local businesses as Winter Garden loses them
Winter Garden's future is uncertain as several downtown buildings are being sold. Neighboring Clermont has a mission to stay local.
Reckoning With State and Federal Cuts, L.A. Safety-Net Clinics Push for a New Tax
By Bernard J. Wolfson | KFF Health News LOS ANGELES — Mia Angulo, who is pregnant and due in May, is living in a tent with her boyfriend in the predominantly Latino neighborhood of Boyle Heights. Lingering pain from a car crash two months ago, on top of an already hardscrabble life, has Angulo ...
As Obama Center nears debut, neighborhood poised for change
In the decade since plans for the Obama Center center were announced, here's how the area around it has changed — and how it hasn't.
Dulio: If faith calls for reflection, politics should too
There are often calls to “lower the temperature.” Real change is impossible until both our leaders and our neighbors accept that their side is part of the problem.
What's the big idea? If you've got it, World Business Chicago wants to know
The organization is calling for architects, designers, neighborhood groups, artists, innovators and interdisciplinary teams to submit visionary ideas that explore what Chicago could look like in 2050.
Sinkhole in Old City causing frustrating for neighbors and businesses
Massive sinkhole in Philadelphia's Old City neighborhood disrupts life for neighbors, businesses
Social Determinants of Health and Access to Orthopedic Care Among Seniors in Little Havana
Introduction: Little Havana, Miami, Florida, is a predominantly Hispanic neighborhood with many adults and seniors aged 65 and older at risk for osteoarthritis, osteoporosis, and associated frac...
A perfectly balanced atom just broke one of nuclear physics’ biggest rules
Physicists have discovered a surprising new “Island of Inversion” in a place no one expected: among nuclei where the number of protons equals the number of neutrons. For decades, these strange regions—where atomic nuclei abandon their usual orderly structure and become strongly deformed—were thought to exist only in highly neutron-rich isotopes far from stability. But experiments on molybdenum isotopes revealed that molybdenum-84 behaves dramatically differently from its close neighbor molybdenum-86, even though they differ by just two neutrons.
Astronomers discover giant cosmic sheet around the Milky Way
For decades, astronomers wondered why most nearby galaxies are speeding away from the Milky Way instead of being pulled in by its gravity. New simulations reveal the answer: our galaxy sits in a gigantic, flat sheet of matter surrounded by huge empty voids. This hidden structure—dominated by dark matter—balances gravitational forces and lets neighboring galaxies drift outward. The discovery finally explains the puzzling motions of galaxies just beyond our Local Group.
Overnight burglary spree hits six Chicago businesses
Chicago police are warning business owners after a string of overnight burglaries targeted six businesses across several South and Southwest Side neighborhoods.
Restaurant in 29 Palms says war in Iran has impacted its business
TWENTYNINE PALMS, Calif. (KESQ) – As the potential for an American ground invasion of Iran remains in question, uncertainty looms in the High Desert. The City of Twentynine Palms is closely intertwined with their Marine neighbors to the north, just five miles away from downtown. Among the people who live and work in the area,
USC student accused of Shandon stabbing released, receiving mental health care, attorney says
An 18-year-old University of South Carolina student accused of stabbing a man walking his dog in Columbia’s Shandon neighborhood has been released from jail and is receiving care at a mental health facility, according to his attorney.
AHA podcast: Advancing Community Health
Doug Brown, partner with Manatt Health and current chair of the AHA’s Foster G. McGaw Prize Committee, discusses how hospitals are tackling food insecurity, workforce development, safe neighborhoods and other social drivers of health through authentic community partnerships. Discover what it takes for hospitals to truly serve as cornerstones of their communities, and how the Foster G.
Buchanan Street residents split over business restrictions from zoning
Buchanan Street neighbors and business owners are weighing the pros and cons of applying a new zoning tool that limits certain types of businesses.
Duluth crews fight fire at Hillside neighborhood business
Duluth firefighters responded to a fire at Palisade Primary Care around 7 p.m. Tuesday evening.
See the entertainment lineup along the 2026 Los Angeles Marathon course
More than 26,000 participants will compete in the sold-out 2026 ASICS Los Angeles Marathon this Sunday along a course lined with lively entertainment. The marathon starts at 7 a.m. from Dodger Stadium. The finish line is at Santa Monica Boulevard and Avenue of the Stars in Century City. The 26.2-mile course goes through some of LA’s most recognizable neighborhoods and landmarks, including Elysian…
Black Political Caucus to file lawsuit to stop I-77 toll lanes
Residents in some historically Black communities say the I-77 widening will hurt their neighborhoods.
The First Fascist Was French, Antisemitic, and … Neighbors With Teddy Roosevelt?
Marquis de Morès had a wild life—and a short one. That’s probably for the best.
March in the Neighborhood: Timepieces and the science of time; Welcoming spring with cleanups and dance | Forest Hills Connection | News and Life in Our DC Neighborhood
Time, as we experience it, is a forward-moving phenomenon. For most of the past century, physicists have also understood time in that way, positing that “the first arrow of time” only increases disorder, or entropy, and there is no backtracking. That, however, does not explain how the complex systems of the universe are able to […]
Where billionaires are moving in Miami: Indian Creek, Coconut Grove
With Larry Page leading what one Miami broker called a "gold rush," these neighborhoods may soon be home to some of the world's richest.
Republican responds: neighbors before politics
To the editor, I read with great interest and compassion the recent letter from a neighbor, Emily Shapiro, who submitted “Is it too late to know thy neighbor?” in the Riverdale Press’s …
Old Town Albuquerque property owners weigh forming a Business Improvement District
Historic Old Town Association president J.J. Mancini says a BID — a mechanism through which property owners pool resources to fund services such as cleaning, maintenance, security and marketing — could take the historic neighborhood's goals and visions 'to the next level.'
Strikes on Iran upend some of the world's busiest airspace
Following US and Israeli strikes, Iran and neighbor nations closed airspace, impacting airlines like Qatar Airways and Emirates.
Vanderbilt Health Pets of the Day: Momo and Smokey
Today’s first Dog of the Day is Momo, submitted by Ginger DeBellis of the Vanderbilt Vaccine Center. “Momo is a sweet and super smart blue merle Australian shepard who loves learning new tricks, neighbor watching and snuggles.“ Today’s second Dog of the Day is Smokey, submitted by Haley Villacorta of Population Health. “Smokey is a Pomsky (Pomeranian and Siberian husky mix).” Pets of the Day — what you need to know The Vanderbilt Health Pets of the Day are included in regular editions of the MyVUMC News newsletter, which is posted twice a week by Vanderbilt Health News and Communications. The pets are selected from the hundreds of entries sent to the Voice Pet Photo Contest. For those who submitted a photo to that contest, watch MyVUMC News for Pets of the Day, and in addition, regular collections of pet photos are posted to the Voice site. You can see them all here: https://news.vumc.org/section/voice/pets-vumc/. If you have a pet you would like to nominate for Pet of the Day, the next Pet Photo Contest submission period is coming up later this year, and will be announced in MyVUMC News. Momo and Smokey were featured in the March 3, 2026, edition of MyVUMC News.
New AirSnitch attack breaks Wi-Fi encryption in homes, offices, and enterprises
That guest network you set up for your neighbors may not be as secure as you think.
Beyond Politics: A Haitian Immigrant’s Call To See People
Cedarville music professor Dr. Lou Lilite, a Haitian immigrant and U.S. citizen, urges neighbors to see immigrants as people, not labels. Visiting Springfield...
Boulder’s bleak oil-and-gas legal entanglements
Good neighbor policy in the fossil-fuel-energy industry stops at Boulder’s door. If any other county or municipality decides to rumble with Exxon Mobil and Suncor Energy over their legal exposure to climate lawsuits, those entities will no doubt face “Bleak House” type legal entanglements also. Charles Dickens’ Bleak House records the estate case of Jarndyce […]
Boutique hotel catering to gay travelers proposed for Northalsted
The proposal highlights the North Side neighborhood's profile as a key tourism magnet for the city.
From campus to community: UCSC brings science to the neighborhood to spark local dialogue
UC Santa Cruz has launched a lecture series that takes researchers out of the lab and into neighborhoods to provide the public with a clearer understanding of cutting-edge science.
How a land dispute between Gov. Josh Shapiro and his neighbor is shaking up a sleepy Abington neighborhood — and why he says it’s a ‘political stunt’
The neighborhood has became the battleground for dueling lawsuits between Josh Shapiro and his neighbors, bringing tension to a tranquil community.
Sound science should drive Colorado’s pesticide policy
By Paul Schlagel As a Coloradan and fourth-generation sugar beet farmer, my relationship with the land and my livelihood depend on balancing healthy soil, vibrant crops, and clean water. Achieving this balance — and providing food to my neighbors here in Longmont — requires essential tools such as scientifically researched and tested pesticides. That’s why […]
Seaport Entertainment Group Announces Lease With Balloon Museum to Transform Historic Tin Building Into a New Cultural Destination
NEW YORK, February 23, 2026--Seaport Entertainment Group Inc. (NYSE: SEG) ("Seaport Entertainment Group" or "SEG") and Lux Entertainment today announced that Balloon Museum, the award-winning contemporary art format, will open at the Tin Building in Summer 2026. The Tin Building will serve as the Balloon Museum’s U.S. flagship, enriching the cultural landscape in the Seaport neighborhood by offering a community-oriented, experiential art destination designed to attract visitors of all ages.
Unequal Access to Nature Fuels America’s Health Crisis
Communities of color and low-income neighborhoods face the worst impacts as the U.S. loses forests, wetlands and other green spaces.
Josh Shapiro to neighbors: Get off my lawn
The Pennsylvania governor and Democratic star is embroiled in a dispute with his neighbor that has escalated into an unlikely political saga.
Black-owned financial business plans Historic Southside relocation
A Fort Worth financial management company is moving from the Woodhaven neighborhood to the 1100 block of East Rosedale Street.
Chicago Bears take key step in proposed Indiana stadium move
The Chicago Bears on Thursday hailed the "most meaningful step" yet toward building a new stadium in Indiana, as the neighboring state passed a key measure to entice the NFL franchise to make a divisive cross-border move.Bears president and chief executive Kevin Warren warned in December that Indiana had become a serious option, and on Thursday the state unanimously passed a bill allowing it to issue bonds for the financing and construction of a new stadium.
Bangladesh's new sports minister wants to 'resolve issue' with India quickly
"We want to maintain friendly relations with all our neighboring countries," new sports minister Aminul Haque says | ESPN.com
Bangladesh's new sports minister wants to 'resolve issue' with India quickly
"We want to maintain friendly relations with all our neighboring countries," new sports minister Aminul Haque says | ESPN.com
GUEST COMMENTARY: When rhetoric replaces reality — the decline of American politics
Since 2015, our nation has drifted further apart. Friends, families and neighbors often stop communicating because of politics. What was once an afterthought for many Americans — especially younger ones — now dominates everyday life. The actions of elected and unelected officials at every level of government are constantly at the center of public attention.
In ‘Neighbors,’ America’s Problem Isn’t Politics. It’s Personal
'Neighbors' directors Dylan Redford and Harrison Fishman discuss their HBO docuseries about fights between neighbors all over America.
A Better Way to Respond to Mental Health Crises
Two men experiencing mental health crises were both wielding knives. One was shot four times by police; the other got a snack and a ride back to his neighborhood. Why?
Property owners launch Rivertown improvement zone
The new zone will fund cleaning, landscaping and security in the neighborhood.
Norway is a Winter Olympic giant. Why isn’t it better at ice hockey?
While Norway rules the 2026 medal table, its hockey teams are at home — a stark difference from its Nordic neighbors Sweden and Finland.
Philly business owners could save thousands with this little-known resource
PIDC provides financing to businesses to create jobs and revitalize neighborhoods.
Immigration raids driving steep business declines in LA immigrant neighborhoods, report finds
According to the report, the 10 ZIP codes most affected by ICE activity span from the San Fernando Valley to Pico Rivera and Huntington Park.
Business on Harry Hines shut down in multi-agency enforcement operation
This comes roughly 10 days after officials announced the expansion of Project Safe Neighborhoods to battle violent crime, drug trafficking and human...
As East Colfax BRT construction approaches Aurora, city leaders look to Denver for lessons on business impact
As construction on the East Colfax Bus Rapid Transit project moves closer to Aurora, business owners and neighbors along the corridor say they are bracing for short-term disruption while holding onto hope for long-term revival.
WEST SEATTLE CRIME WATCH: Business break-in attempt
The report is from Jen, who says two people tried to break into The Void and Little Shop of Hairdos just south of The Junction early today, and sent images: 5:10 this morning, these two tried to break into The Void and the back door to Little Shop, met with too much resistance and interrupted by a neighbor. Appears to be the same MO and two ...
How business students learn to make ethical decisions by studying a soup kitchen in one of America’s toughest neighborhoods
For 50 years, St. Francis Inn in Philadelphia has served the poorest and most vulnerable people in Kensington.
How business students learn to make ethical decisions by studying a soup kitchen in one of America’s toughest neighborhoods
For 50 years, St. Francis Inn in Philadelphia has served the poorest and most vulnerable people in Kensington.
Neighborhood comeback with business incubator | FOX 13 Tampa Bay
A once economically-thriving North Clearwater community could be on the brink of a comeback, as local leaders launch a business incubator designed to create opportunity and support entrepreneurs. FOX 13's Jennifer Kveglis reports.
Clearwater business incubator aims to spark revival in once thriving North Greenwood neighborhood
A once economically-thriving North Clearwater community could be on the brink of a comeback, as local leaders launch a business incubator designed to create opportunity and support entrepreneurs.
Seahawks parade brings business to multiple Seattle neighborhoods
After the Seahawks took their victory lap through the heart of downtown as champions, a sea of navy and green flooded Seattle as fans continued to celebrate.
2025 US ACT on Health Equity Community Investments Recipients
Author: Kennesha VanBurch, Director, Health Equity and Community Investment Partnerships 2025 marks the fifth year of the US Accelerate Change Together (ACT) on Health Equity: Community Solutions Challenge (CSC) and National Strategic Collaborations (NSC). This year, we received more than 250 applications from organizations across the country dedicated to prioritizing the social, cultural and linguistic needs of communities that have experienced barriers to care and opportunity. The overwhelming response underscores the vital role these organizations play in advancing health equity at the local level and across the nation. Since the launch of ACT on Health Equity in 2021, the initiative has invested more than $18 million in nonprofit organizations and their health equity programming through CSC and NSC. This year, $3.4 million in funding has been provided to 47 nonprofit organizations that focus on healthcare access, nutrition and lung health. Together, we are making meaningful progress toward health equity across the US. Supporting Organizations Advancing Community Well-being and Health Equity The awarded organizations address critical needs across health, education, and social support through initiatives aligned with AstraZeneca’s areas of expertise, including lung disease, lung and breast cancer, and cardiology. Their work spans across culturally competent senior care, equitable healthcare access, cancer and chronic disease support, and preventive health education, as well as hunger relief, community gardening, dental and transportation services, and resources for underserved families. Together, they are working to remove barriers to care, reduce preventable conditions, and empower individuals and communities of all ages and backgrounds to achieve better health outcomes. Photo courtesy of Medical Motor Service of Rochester and Monroe County, Inc. Description: MMS driver speaking to a Wegmans shopper. GGWNY staff; Lincoln Memorial Church Community Garden and lead gardener Diane Learn more about our recipients and the impact they make within their communities below. Community Solutions Challenge Advocates for Women’s Health, Inc. Advocates for Women's Health exists to provide access to high quality prenatal care and gynecology care to lower-income communities in and around Fresno, CA. They operate a nonprofit OB/GYN clinic located in Fresno. American Rescue Workers (ARW) ARW is a faith-based, non-profit organization providing homelessness and hunger prevention services in Central PA since 1934. ARW cares holistically for men, women, and children who find themselves facing food insecurity, and emergency situations that may lead to homelessness, or an actual homeless crisis, by providing shelter and social services. ARW serves people no matter their faith, regardless of faith. Asian Americans Advancing Justice Southern California (AJSOCAL) AJSOCAL is a social justice organization that protects and strengthens the rights and dignity of AAPI communities, especially those that are most disadvantaged. Byrd Cancer Education and Advocacy (BCEA) BCEA’s mission is to effectively assist individuals battling cancer by connecting them to vital support and resources. BCEA ensures that all relevant information reaches those in need, guiding them towards the resources necessary to fight their battle against cancer. Catholic Charities of the Diocese of Santa Rosa Catholic Charities of the Diocese of Santa Rosa creates access to opportunities for self-sufficiency by providing innovative and compassionate services to people of all backgrounds, beliefs and cultures. Chosen Hearts Chosen Hearts’ mission is to rebuild lives and restore hope by fostering a sense of community and creating lasting, positive change. Columbia Student Medical Outreach The Columbia Student Medical Outreach Program (CoSMO) Clinic is the oldest and largest student-run free clinic at the Vagelos College of Physicians and Surgeons at Columbia University. At its core, CoSMO is guided by the belief that all people—regardless of immigration or insurance status—deserve access to high-quality, equitable medical care. Eagle’s Nest Community Kitchen and Resource Center and Mobile Pantry Eagle’s Nest Community Kitchen, Resource Center and Mobile Pantry’s mission is to empower underserved and rural communities through hands-on STEM education grounded in sustainable agriculture. By combining mobile workshops, community gardens, and mentorship, they deliver accessible training in science, technology, engineering, and math that builds practical skills, advances food security, and fosters environmental stewardship. Through collaborative partnerships and by honoring local knowledge, they cultivate resilient communities and inspire the next generation of agricultural innovators. eClose Institute eClose Institute’s mission is to make medically relevant scientific discoveries using an education platform that embraces equality and empowers participants to contribute ideas, life experience and experimental data to improve disease treatment. Equal Hope Equal Hope is an organization dedicated to saving lives and improving quality of life by eliminating health inequities. This organization challenges the status quo in striving to understand the context of people’s lives and the barriers they experience to help them achieve better health outcomes for their lives. Through research, quality assessment and improvements, advocacy, education, and patient navigation, they approach health holistically to achieve sustainable outcomes and true health equity. Food For Free Committee Food For Free improves access to healthy food through establishing innovative programming and partnerships to overcome barriers and strengthen the community food system. They believe that access to healthy food is a fundamental right. Grassroots Gardens of Western New York (GGRWNY) The missions of GGRWNY is to share knowledge, powers, and resources to grow health food, heal systemic harm, and strengthen neighborhood connections through community gardens. Greater Providence YMCA (GPYMCA) GPYMCA builds healthy spirit, mind, and body for all, through inclusive programs and relationships grounded in core values of caring, honesty, respect, and responsibility. Programs are intentionally designed to close equity gaps in health, education, and wellness. GPYMCA serves individuals and families across all life stages and income levels, including medically vulnerable and underserved populations. Hearts of Valor INC Hearts of Valor’s missions it to keep the heart pumping through advocacy, collaboration, education, and support. Ibn Sina Foundation Ibn Sina Foundation ensures the health of the community by providing integrated, preventive, and primary care in a clinical setting through the dissemination and application of health-related knowledge, thereby enhancing the quality of life for future generations. India Home India Home is a non-profit organization dedicated to addressing the needs of and empowering the South Asian and Indo-Caribbean senior immigrant community in New York City through culturally competent services. At India Home’s centers, seniors find community and resources through a diverse range of programs and activities. Programs include congregate meals, creative aging programs, case management programs, and educational talks on health, nutrition, financial safeguards and elder law. La Colaborativa La Colaborativa empowers the Latinx community, enhancing social and economic health, and holding institutional decision-makers accountable. Lancaster County Food Hub At the heart of the Lancaster County Food Hub’s (LCFH) work is a strong commitment to meeting basic human needs, fostering respectful relationships, and connecting neighbors with supportive services in a nurturing and welcoming environment. Guided by their vision of a Lancaster County where every individual is supported and empowered to live with dignity and stability, they strive to not only provide immediate relief but also to create pathways to lasting self-sufficiency. Maryland Foundation of Dentistry (MFD) MFD is dedicated to improving oral health outcomes and preserving dental function for one of the state’s most vulnerable populations: adults with intellectual, physical, and/or developmental disabilities who are unable to afford the cost of dental care. Maternity Care Coalition (MCC) The missions of MCC is to improve the health and well-being of pregnant women and parenting families and enhance school readiness for children 0-3. MCC achieves this through direct service, advocacy, and research, in collaboration with individuals, families, providers, and communities. Medical Motor Service of Rochester and Monroe County, Inc. Medical Motor Service of Rochester and Monroe County’s mission is to provide specialized transportation for community organizations, as well as individuals with disabilities and special needs to improve their independence and quality of life. Milwaukee Consortium for Hmong Health (MCHH) MCHH’s mission is to create a thriving and healthy Southeast Asian and Hispanic community by empowering families through education and screenings. MCHH utilizes established community health workers and focuses on addressing health disparities related to cancer and chronic disease among the Hmong, Bumese, Karen, Karenni, Lao, and Hispanic populations living in Milwaukee, WI and other areas if needed. Mission Hospice and Home Care Mission Hospice and Home Care is delivering compassionate support and exceptional care in the home for individuals and communities, guiding them with choice and dignity to navigate significant care decisions. North Alabama AHEC (NAAHEC) The mission of the NAAHEC is to improve healthcare access, quality, and equity in rural and underserved communities across North Alabama. They strengthen the health workforce - particularly through the development of community health workers by providing comprehensive training, resources, and advocacy. By fostering strong community partnerships and promoting healthcare literacy, NAAHEC aims to address disparities, improve outcomes, and cultivate a healthier future for North Alabama. Our Neighbors’ Table Hunger comes in many forms. Our Neighbors’ Table is committed to establishing a community that provides for the whole person with nourishing food, kindness and dignity. Panhandle Breast Health Panhandle Breast Health works to decrease breast cancer deaths by providing education and reducing financial barriers to increase screening rates. Pitney Meadows Community Farm Founded in 2026, Pitney Meadows Community Farm’s mission is to celebrate and explore agricultural education, healthy food production, and recreation. Located on 166 acres in the heart of the city of Saratoga Springs and preserved in perpetuity as a working farm, Pitney Meadows is a unique resource. Prince William County Community Foundation (PWCCF) PWCCF’s mission is to create a stronger, healthier, and more connected community by addressing critical needs in food insecurity, health & wellness, scholarship, and philanthropy. PWCCF is committed to empowering individuals and families through equitable access to nutritious food, comprehensive healthcare, educational opportunities, and community-driven support. By fostering partnerships and promoting sustainable solutions, PWCCF aims to enhance the quality of life for all, ensuring a brighter future for every member of their community. Raytown Christian Church (Raytown Summer Lunch Ministry) Raytown Summer Lunch Ministry’s mission is to provide nutritious and kid-friendly meals to children during the summer months when they are not in school and receiving school meals. Regents of the University of California, Davis UC Davis Health is improving lives and transforming health care by providing excellent patient care, conducting groundbreaking research, fostering innovative, interprofessional education, and creating dynamic, productive partnerships with the community. RSVP Volunteers RSVP Volunteers creates and runs unique community programs powered by skilled volunteers to advance education and wellness for all ages and strengthen nonprofits through capacity-building and volunteer services. Second Harvest Food Bank of Orange County Second Harvest Food Bank of Orange County, in collaboration with partners, provides dignified, equitable and consistent access to nutritious food, creating a foundation for community health. The Icla da Silva Foundation The mission of the Icla da Silva Foundation is to save the lives of patients whose only cure is a bone marrow transplant by providing financial, emotional, and logistical support to remove barriers to treatment. There With Care of the Bay Area Founded in 2012, the mission of There With Care of the Bay Area is to provide a wide range of meaningful and fundamental services to children and families during the critical phase of a medical crisis. Universal Community Health Center Universal Community Health Center’s mission is to provide quality and accessible healthcare to under-served communities and to provide a patient centered model of care to empower communities towards wellness. West Cancer Foundation West Cancer Foundation breaks through barriers to cancer care and improves patient outcomes by providing accessible patient resources, early detection and education, and community-based research. Westside Family Healthcare Westside Family Healthcare’s mission is to improve the health of communities by providing equal access to quality healthcare, regardless of ability to pay. National Strategic Collaborations Foundation of Asthma and Allergy Impact Rescue (AAIR) The mission of The Foundation for Asthma and Allergy Impact and Rescue (AAIR) is to make sure that every child is rescued at school, healthy at home, and connected to care. Family Reach Foundation Family Reach is a nonprofit that provides non-medical financial support to families facing cancer. Cancer treatment requires more than medicine — families need a roof over their heads and food on their tables to survive. If a family can’t meet these basic needs, cancer treatment takes a back seat. They work with patients, providers, and community organizations to challenge the systems that force families to choose between their health and their home. LUNGevity Foundation LUNGevity Foundation is transforming what it means to be diagnosed and live with lung cancer through research, advocacy, and community. This mission brings them closer to their vision: a world where no one dies of lung cancer. Association of Black Cardiologists The Association of Black Cardiologists is dedicated to preventing and treating cardiovascular disease, including stroke, through education, research, advocacy, and community engagement, striving for optimal health for all by eliminating disparities. Cholangiocarcinoma Foundation (CCF) The Cholangiocarcinoma Foundation’s (CCF) mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma (bile duct cancer). Founded in 2006, in Salt Lake City, UT, by a family who lost a loved one to cholangiocarcinoma, CCF has grown to become the leading global resource in research, education, and public awareness. ZERO Prostate Cancer Zero Prostate Cancer’s mission is to improve and save lives from prostate cancer through advocacy, awareness, education, and support. GO2 for Lung Cancer GO2 for Lung Cancer relentlessly confronts lung cancer on every front, every day, for everyone. As the nation’s leading lung cancer advocacy organization that was founded by patients and survivors, they are dedicated to increasing survival and quality of life for those at risk, diagnosed, and living with lung cancer. National Minority Quality Forum The National Minority Quality Forum (NMQF) is a national 501(c)(3) with a mission to reduce patient risk for all. Young Survival Coalition (Breast) Young Survival Coalition supports the young breast cancer community and ignites global collaboration to improve quality of life worldwide. Black Women’s Health Imperative Black Women’s Health Imperative’s mission is to solve the most critical health issues that Black women and girls face through innovative programs, transformative research, and lifesaving policies.
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