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AFC Bournemouth vs Brentford: Is This A 'Must Win' Game?
Tomorrow, Cherries face an in form Brentford side that are yet to lose so far this season, and with European football soon to start, is this the first must win game of the season for Marco Rose's men?
Sweden's election could mark major milestone for Europe's populist right
Once shunned over its extremist roots, the Sweden Democrats could enter government for the first time as voters weigh immigration, crime and Sweden's political transformation.
‘The Europe she fought for will miss her’: Politicians pay tribute to Emma Bonino
The Italian civil rights activist and former European commissioner has died at the age of 78.
Are you smarter than a 15-year-old? Try these OECD Pisa tests
This week, the OECD's PISA report has revealed a global decline in 15-year-old's maths and reading skills — but how much better can the grown-up's fare?
Ochsner Lafayette General Welcomes New Physicians
Ochsner Lafayette General welcomes new physicians in infectious diseases, orthopedics, psychiatry, pediatrics and pediatric neurosurgery across Acadiana.
📸 This week’s viral Champions League images 🍿
The Champions League is wild! A look at the most bewildering moments from this European week, starting with Michael Olise’s hilarious — and now viral — interview on DAZN. Another surreal Olise ...
Emma Bonino, prominent humanist in Italian politics, dies at 78
A tireless defender of human rights, Emma Bonino served in the Italian and European parliaments, as foreign affairs minister, and as European commissioner. The historic figure of the Italian Radical Party died in Rome on Friday.
🗞️ Raphinha, Lamine Yamal and the Cesc effect: Friday's covers
The sports newspaper front pages this September 11 are packed with big names, continental surprises, and tensions handled in global boardrooms. Barcelona’s takeoff, Como’s European debut, and the ...
Major airline launches new business class suites with sliding doors
The new suites will be available on select flights to Europe and New York in 2027.
Taiwan vice president makes rare Europe visit for conference on democracy
European Parliament's Pina Picierno says Hsiao's visit 'was kept secret until her arrival to protect her participation'.
Wasps are disappearing this summer, and scientists are worried
Britain’s wasps have become mysteriously scarce this summer, and scientists suspect an unusual combination of temperature swings, heatwaves, and food shortages may be responsible. Even the wasps that remain appear unusually small, potentially offering a glimpse of how extreme heat could reshape insect populations.
Man Utd outclass Sabah on Champions League return
Manchester United cruised to a 4-0 win on their return to the Champions League for the first time in three seasons as Azerbaijani champions Sabah were taught a lesson on their debut among Europe's elite on Thursday.For coach Valdas Dambrauskas it was a return to Old Trafford after his fairytale rise to the Champions League began with a role at Manchester United Soccer Schools, while working several part-time jobs just to make ends meet.
How Caring for Grandkids Can Help with Brain Health
National Grandparents Day is this Sunday. A neurologist offers some insight on a study showing how caring for your grandkids can help with brain health as you age.
Sabah make crazy UCL history despite Man Utd humbling 🌍
Sabah's opening Champions League encounter was always set to be historic.The reigning Azerbaijani champions made their foray into Europe's elite club competition with a prestige meeting against Manche...
How geopolitical rifts cut scientific collaboration
Researchers have measured how worsening geopolitical relations hobble scientific collaboration, at last quantifying the impact of rifts between governments on cooperation between labs. Over the last decade, a tenser world has thrown up new barriers to cross-border science. Collaboration between the US and China has dimmed as the two countries have sunk into an ever-deeper rivalry. Links between Russia and Europe have collapsed following Moscow’s full-scale invasion of Ukraine. But while a concern, the magnitude of the damage is less than might be expected. For all the geopolitical turmoil of the last decade, international scientific collaborations are near a record high. “Some part of the story is positive,” said Shreyas Gadgin Matha, a social scientist at Harvard University and an author of the new study. “Research collaborations are largely resilient.” Matha and colleagues looked at data on cross-border research papers and patents in the period 2000-23, and analysed how they were impacted by countries’ political relations, as measured by how often states voted together in the United Nations. They found that when states drift apart at the UN by the median difference in votes between all countries, joint scientific papers decline by 3.1% over the next three-year period. To put that in context, over the last decade, the US and China have diverged by around a third of that difference in votes every three years. In other words, on average, it takes quite a significant diplomatic rift even to trigger a small single-digit percentage drop in joint papers. “In the short term, even something like a 3% reduction [in joint papers] is, in some ways, not that big of a number,” said Matha. Research remains more international than ever, according to an analysis extending to 2023 released by the Organisation for Economic Cooperation and Development (OECD) in 2025. We’re still living in an era of unprecedented scientific globalisation, the analysis says, with 27% of papers in OECD countries written across borders. In 1970, just 2% of articles had authors from different countries. Longer-term damage?However, this trend towards increasing international collaboration “has lost momentum and might be partly breaking down,” the OECD analysis says, largely due to a fall in the intensity of US-China joint papers since 2018. Matha and his colleagues stressed they are not complacent about the global science system. For now, “it's pretty resilient,” said co-author Muhammed Yildirim, director of academic research at Harvard’s Growth Lab. But if links are weakened, through the denial of study visas, for example, then this could have a much longer-term effect, cascading through generations of scientists, he added. Related articlesChina becomes Russia’s biggest collaborator after war decimates science ties with the west US scientists prefer German to Chinese collaborators, study finds Horizon Europe is now truly global. But what comes next? Another finding of the study, Burning bridges or bridging divides: Geopolitics and collaboration in research and innovation, is that trust appears easier to destroy than create.The hit to scientific collaboration when countries drift apart is around three times as big as the growth in joint papers when they move closer, the paper finds. “It's far easier to break these ties than to mend them, and that that also perhaps has some larger policy lesson,” said Matha.PatentsThe results around patents were less clear cut. Some methods of analysis found a statistically significant link between a diplomatic rift and a drop in co-patenting, but others did not. According to Yildirim, patents with cross-border inventors are often developed by multinational companies, which may have invested heavily in global R&D facilities, so are less likely to change how they operate simply due to a change in the geopolitical weather. “That's why we might not be seeing the effect immediately in technology,” he said.By contrast, researchers might be more sensitive to geopolitics, because visa policies can quickly affect who meets who at academic conferences, he went on. International collaboration on patents is much lower than for academic articles, the study shows. It peaked at around 10% in 2010, and has since fallen back to around 8%. This could be because China dramatically ramped up domestic patents in the 2010s, said Yildirim, squeezing the international share.
How geopolitical rifts cut scientific collaboration
Researchers have measured how worsening geopolitical relations hobble scientific collaboration, at last quantifying the impact of rifts between governments on cooperation between labs. Over the last decade, a tenser world has thrown up new barriers to cross-border science. Collaboration between the US and China has dimmed as the two countries have sunk into an ever-deeper rivalry. Links between Russia and Europe have collapsed following Moscow’s full-scale invasion of Ukraine. But while a concern, the magnitude of the damage is less than might be expected. For all the geopolitical turmoil of the last decade, international scientific collaborations are near a record high. “Some part of the story is positive,” said Shreyas Gadgin Matha, a social scientist at Harvard University and an author of the new study. “Research collaborations are largely resilient.” Matha and colleagues looked at data on cross-border research papers and patents in the period 2000-23, and analysed how they were impacted by countries’ political relations, as measured by how often states voted together in the United Nations. They found that when states drift apart at the UN by the median difference in votes between all countries, joint scientific papers decline by 3.1% over the next three-year period. To put that in context, over the last decade, the US and China have diverged by around a third of that difference in votes every three years. In other words, on average, it takes quite a significant diplomatic rift even to trigger a small single-digit percentage drop in joint papers. “In the short term, even something like a 3% reduction [in joint papers] is, in some ways, not that big of a number,” said Matha. Research remains more international than ever, according to an analysis extending to 2023 released by the Organisation for Economic Cooperation and Development (OECD) in 2025. We’re still living in an era of unprecedented scientific globalisation, the analysis says, with 27% of papers in OECD countries written across borders. In 1970, just 2% of articles had authors from different countries. Longer-term damage?However, this trend towards increasing international collaboration “has lost momentum and might be partly breaking down,” the OECD analysis says, largely due to a fall in the intensity of US-China joint papers since 2018. Matha and his colleagues stressed they are not complacent about the global science system. For now, “it's pretty resilient,” said co-author Muhammed Yildirim, director of academic research at Harvard’s Growth Lab. But if links are weakened, through the denial of study visas, for example, then this could have a much longer-term effect, cascading through generations of scientists, he added. Related articlesChina becomes Russia’s biggest collaborator after war decimates science ties with the west US scientists prefer German to Chinese collaborators, study finds Horizon Europe is now truly global. But what comes next? Another finding of the study, Burning bridges or bridging divides: Geopolitics and collaboration in research and innovation, is that trust appears easier to destroy than create.The hit to scientific collaboration when countries drift apart is around three times as big as the growth in joint papers when they move closer, the paper finds. “It's far easier to break these ties than to mend them, and that that also perhaps has some larger policy lesson,” said Matha.PatentsThe results around patents were less clear cut. Some methods of analysis found a statistically significant link between a diplomatic rift and a drop in co-patenting, but others did not. According to Yildirim, patents with cross-border inventors are often developed by multinational companies, which may have invested heavily in global R&D facilities, so are less likely to change how they operate simply due to a change in the geopolitical weather. “That's why we might not be seeing the effect immediately in technology,” he said.By contrast, researchers might be more sensitive to geopolitics, because visa policies can quickly affect who meets who at academic conferences, he went on. International collaboration on patents is much lower than for academic articles, the study shows. It peaked at around 10% in 2010, and has since fallen back to around 8%. This could be because China dramatically ramped up domestic patents in the 2010s, said Yildirim, squeezing the international share.
Kentucky crafters build business space for disabled, neurodivergent artists
Mystic Zebra Crafts is working toward a storefront where disabled and neurodivergent crafters can sell work and build community.
Kentucky crafters build business space for disabled, neurodivergent artists
Mystic Zebra Crafts is working toward a storefront where disabled and neurodivergent crafters can sell work and build community.
Kentucky crafters build business space for disabled, neurodivergent artists
Mystic Zebra Crafts is working toward a storefront where disabled and neurodivergent crafters can sell work and build community.
Scientists say August was Earth's hottest month they've measured
The European climate service Copernicus said the Earth just sweltered through its hottest month on record in August. Scientists said the heat surge is mostly due to human-caused climate change.
The Sidemen Rep Arcade Signs Max Fosh, Friends From Work & More Ahead Of Europe’s First Creator Upfront
EXCLUSIVE: Arcade, the management company of The Sidemen, has signed a host of creators, as it relaunches as an entertainment business ahead of its first European upfront. Comedian Max Fosh, creator c...
Spanish Grand Prix 2026: Can football-obsessed Madrid embrace F1?
After F1’s explosion in popularity away from its European heartland the sport is coming home. Why Madrid? Because it is beautiful… and has a very big expo centre on the outskirts.
Yourgene Health Insight DPYD assay achieves IVDR accreditation
Yourgene Health (part of the Novacyt Group), an international molecular diagnostics company with a broad portfolio of integrated technologies and services, announces the commercial launch of its In Vitro Diagnostic Regulation (IVDR)-certified Yourgene® Insight DPYD assay, expanding the Company's clinical genetics portfolio across regulated European markets.
Yourgene Health launches Insight DPYD assay (IVDR)
Yourgene Health (part of the Novacyt Group), an international molecular diagnostics company with a broad portfolio of integrated technologies and services, announces the commercial launch of its In Vitro Diagnostic Regulation (IVDR)-certified Yourgene® Insight DPYD assay, expanding the Company's clinical genetics portfolio across regulated European markets.
Global heat stuck on high. Scientists say August was Earth’s hottest month they’ve measured.
The European climate service Copernicus said the Earth just sweltered through its hottest month on record in August.
Global heat stuck on high. Scientists say August was Earth's hottest month they've measured.
The European climate service Copernicus said the Earth just sweltered through its hottest month on record in August
Global heat stuck on high. Scientists say August was Earth's hottest month they've measured.
The European climate service Copernicus said the Earth just sweltered through its hottest month on record in August.
Viewpoint: Unlocking Europe’s wildfire data
Europe is already investing in the science, technology and infrastructure needed to understand, prevent and fight wildfires. Copernicus provides satellite-based Earth observation and environmental information, while the European Forest Fire Information System provides information on fire danger and forest fires across Europe. Weather and climate systems add forecasts of heat, drought, wind and humidity; historical fire databases show where fires have occurred; and researchers generate increasingly detailed knowledge about fuels, fire behaviour, forecasting, modelling and risk management. Meanwhile, new European research projects are adding digital twins and other tools to this growing ecosystem.However, these data do not necessarily sit together, nor are they necessarily described, structured or governed in ways that allow them to be used together. Much of the information is public, but some is commercially held. Some is sensitive. Some is subject to legal, security or operational restrictions. Even when data can be legally accessed, different systems may use different formats, terminology and rules.Europe therefore faces an unusual paradox: we have vast amounts of relevant information to respond to the wildfire challenge, but not the means to bring it together. For example, a wildfire researcher or emergency service might need to ask whether a particular combination of vegetation, drought, wind and topography has historically been associated with rapid fire spread. The relevant information may exist in several institutions, using different systems and subject to different conditions of access.The challenge is to conduct an authorised analysis that interacts with these sources, combines the results and respects the rules imposed by each data custodian.An important part of the answer can be found in the Fair principles, the idea that data should be findable, accessible, interoperable and reusable. Developed more than a decade ago, these principles have become a central reference point for modern data stewardship, making it easier for people and machines to find data, understand what it means and determine whether it can be reused.Readability by machines is essential, since AI systems will be key to meeting the data challenge. Bring analysis to the dataThe proposition is not to give an AI system unrestricted access to sensitive databases. Quite the opposite. The goal is to make it possible for approved algorithms to go to the data, rather than requiring sensitive data or large datasets to be copied to wherever the analysis happens.Imagine an analysis asking a series of questions of different data stations. At one station it might examine weather and climate data; at another, historical fire records; at another, experimental measurements of fire behaviour. The algorithm does not need to download everything. It can operate within the environment permitted by each data custodian and return only the results that the rules allow to leave.This is sometimes described as data visiting, and related approaches already exist in areas such as federated analysis and federated learning.Sensitive data should therefore not be treated as a free-for-all for machines. This requires appropriate governance at multiple levels. Access needs to be authenticated and authorised. The purpose of an analysis should be defined. The code or model being run should be controlled. Data custodians should be able to specify what can be queried and what results can leave their environment. Activities should be auditable and human oversight should remain where the consequences require it.In other words, the objective is not to trust AI with the data. It is to design systems in which AI never has more access than it needs.As open as possible, as closed as necessaryFair data should also not be confused with open data. Some wildfire data should be openly available. Other information may legitimately need to remain restricted because it concerns critical infrastructure, security, commercial interests, privacy or operational capabilities. The principle should be: as open as possible, as closed as necessary.The important point is that restricted data should not automatically become unusable data. If machines can discover what information exists, understand its meaning, establish where it came from and determine the conditions under which it can be used, authorised analyses can potentially be carried out without the underlying data ever leaving the environment in which it is protected.Restricted data can still be Fair and machine-actionable.This is also an important question of data sovereignty. European institutions should not have to surrender control of their data to a handful of technology platforms in order to benefit from AI. Nor does Europe need to start again by building one giant repository for every piece of wildfire information. The better approach is to connect what already exists.This is the principle behind emerging approaches such as Tryangle, developed through the Leiden Initiative for Fair and Equitable Science. Rather than creating another centralised data warehouse, the approach seeks to provide an interoperable layer through which approved algorithms can visit distributed data sources while respecting the rules of their custodians.In this way, a data station can remain where it is. Its custodians can retain control. Existing databases and applications do not have to be abandoned. What changes is their ability to communicate with other systems through common, machine-readable descriptions, access rules and interoperability mechanisms.But approaches like this need data that meets the Fair principles. Only then can an interoperable ecosystem safely begin to turn fragmented information into collective intelligence.Data infrastructure is wildfire infrastructureThe implications of this approach are entirely practical. Firefighters could gain better intelligence about local and evolving risks. Land managers could test prevention strategies using more comprehensive information about fuels, weather and past fires. Researchers could compare evidence across ecosystems without repeatedly moving huge datasets between institutions. Smaller regions and resource-constrained teams could access analytical capabilities without having to build large data infrastructures themselves.Europe is already investing heavily in satellites, databases, research programmes, forecasting systems and scientific expertise. The question is whether we will connect those investments well enough to turn them into actionable intelligence.That requires policymakers and funders to treat data infrastructure as seriously as physical infrastructure. Data generated or supported through European public funding should be Fair, verifiable and machine actionable by design, wherever legally and ethically possible.Related articlesData Corner: Europe’s burning need for wildfire mitigation researchClimate monitoring must remain a global enterprise, experts sayIn practice, that means funding not only the production of data, but also the infrastructure that makes data usable across systems: metadata, provenance, interoperability, access mechanisms and governance. Where data must remain restricted, we should ensure that it can still be securely discovered, verified and used for authorised analysis.Initiatives such as the European Open Science Cloud offer an existing framework through which these principles can be put into practice. What is needed now is to accelerate implementation and make them a standard part of how Europe funds and builds research and innovation systems.We do not need another generation of disconnected databases. The data is already there. The opportunity is to make it work together, securely, responsibly and quickly enough to help prevent the next fire, rather than simply document the last one.Jean-Claude Burgelman is professor emeritus at the Free University of Brussels (VUB) and editor-in-chief at Frontiers Policy Lab. For more than 20 years he held leading roles in research and innovation policy at the European Commission.
Flying Car With (Tiny) NH Angle Gets the OK in Europe: Business NH Magazine
PAL-V, the Dutch firm that has been working for decades on a flying car held aloft by a helicopter-like rotor, has gotten a production license from the European aviation safety agency.
World Alzheimer’s Month: How far has science come?
The following expert commentary can be used by journalists and media organizations in their own publications and news coverage. Please attribute all quotes to David Hunter, MD, associate professor at UTHealth Houston and behavioral neurologist and neuropsychiatrist with UT Physicians. Alzheimer’s disease, named for the German pathologist Dr. Alois Alzheimer, is a progressive brain disorder that affects a person’s memory and ability to carry out daily tasks. The number of Americans
Boston Dynamics spinoff looks to build robots for entertainment
Dynamic Creatures is building theme park robots on Chinese hardware. Europe's own social robotics champion was sold to a Shenzhen buyer last year.
Nine Years Since Brighton's First Ever Premier League Win
Relive the historic afternoon a Pascal Groß masterclass dismantled West Brom, sparking a transformative journey from top-flight newcomers to European contenders under the lights of the Amex.
Yourgene Health Releases IVDR-Certified DPYD Assay for Chemotherapy Toxicity Detection
Yourgene Health launches IVDR-certified DPYD assay in Europe to detect 19 variants linked to fluoropyrimidine chemotherapy toxicity.
OneSkies Makes Business Class More Accessible
TAMPA, Fla., Sept. 09, 2026 (GLOBE NEWSWIRE) -- OneSkies, a travel service focused on premium international airfare, is helping U.S. travelers explore competitive business class flight options for long-haul trips to destinations across Europe, Asia, the Middle East and beyond. As travelers increasingly prioritize comfort on international journeys, business class is attracting interest beyond traditional corporate travel. Vacationers, entrepreneurs, couples, families and experienced travelers are
Barcelona vs Feyenoord, Champions League: TV & Streaming, Live Thread
Join us for the first Barcelona European adventure of the season!
Jeremy Farrar Joins Global Health Non-Profit PATH Following Unexpected Departure From WHO
Outgoing WHO Assistant Director-General Dr Jeremy Farrar will lead PATH’s regional division for Asia, the Middle East, and Europe starting 1 October. Based in Geneva, he joins the executive leadership team to accelerate the delivery of health technologies across these regions, the organisation announced in a press release on Wednesday, 9 September.
Germany must relearn the language of power-politics
To protect Europe from Russian aggression, Germans must resolve a tension that lies the heart of their modern national identity: a clash between the ideals of ‘Never Again Fascism’ and ‘Never Again Germany’.
Slime mould has no brain, no neurons and no central control, yet when scientists placed food at 36 locations matching cities around Tokyo, it grew a network strikingly similar to the rail system — with comparable efficiency, cost and resilience
A single-celled organism with no brain solved a transportation puzzle that took human engineers decades to perfect.
JPMorgan expands corporate banking business to Greece
JPMorgan has expanded its corporate banking business to Greece, the U.S. bank said on Wednesday, as part of a broader plan to grow its services for companies across Europe.
Europeans struggle to imagine 'credible' future, study finds
New research identifies an 'imagination gap' as where political choices can still matter
Europeans struggle to imagine 'credible' future, finds study
New research identifies an 'imagination gap' as where political choices can still matter
Ticket sales for our Europa League match in Sofia
UEFA Europa League's league phase startsTo kick off the 2026/27 UEFA Europa League league phase, our team will visit Levski Sofia at the Vasil Levski National Stadium on Thursday 17 September at 18:45...
Belgium battle could be a blessing
It is a new chapter for Aston Villa and, against Club Brugge, they turned the page. A first win of the season, albeit more nervy than anticipated, lit the spark for Unai Emery's side. The visitors were in a commanding and deserved position at half-time, John McGinn's opener making him the club's all-time record European goalscorer with 12.
Seagulls must learn from slow start
It's been a busy start to the 2026-27 campaign for Brighton and Fabian Hurzeler must now begin to prepare for a packed schedule of domestic and European football. Although the Seagulls will wait until October for their Conference League league phase to start, Hurzeler's side has endured a flurry of mixed results in their opening five games of the season. After a bruising 4-3 loss at Stamford Bridge to transfer-foes Chelsea, Brighton were lucky to escape with a 1-1 draw at home to Leeds.
Champions League
A new edition of the UEFA Champions League is under way, with Inter opening their 2026/27 European campaign with a defeat away to Real Madrid. Europe’s premier club competition will now take a break...
Real Madrid, PSG, Liverpool: Ranking Europe's greatest dynasties
Paris St-Germain are eyeing a third successive Champions League crown, but where do they rank against Europe's most dominant clubs?
Arsenal XI vs Napoli – Predicted lineup and team news
Arsenal open their Champions League campaign at Napoli on Wednesday, returning to the Stadio Diego Armando Maradona for the first time since their 2019 Europa League quarter-final win there. Mikel Art...
A Marine Science Michelangelo?
Angelique Allen merges ocean art and octopus neuroscience at Santa Barbara Sea Glass & Ocean Arts Festival.
UNC Charlotte's Truman Lab awarded new $2.1 million grant from the National Institutes of Health
UNC Charlotte’s Truman Lab has secured a new $2.1 million grant from the National Institutes of Health to advance fundamental research on how cells maintain protein health, a process central to diseases ranging from cancer to neurodegenerative disorders. The five-year Maximizing Investigators’ Research Award from the National Institute of General Medical Sciences will support the […]
UNC Charlotte's Truman Lab awarded new $2.1 million grant from the National Institutes of Health
UNC Charlotte’s Truman Lab has secured a new $2.1 million grant from the National Institutes of Health to advance fundamental research on how cells maintain protein health, a process central to diseases ranging from cancer to neurodegenerative disorders. The five-year Maximizing Investigators’ Research Award from the National Institute of General Medical Sciences will support the […]
Porto vs Manchester City Match: Champions League Live Updates
Porto hosts Manchester City at the Estádio do Dragão on Tuesday, September 8, in the opening round of the 2026-27 UEFA Champions League phase. Both teams enter the European opener in strong domestic form and will be looking to start their Champions League campaigns with a positive result. Kickoff is scheduled for 8 p.m. BST, […] The post Porto vs Manchester City Match: Champions League Live Updates appeared first on HEAVY.
Years before Nepal floods, scientists pitched a seismic warning system
The scientists, who are based in Europe, say the system could have triggered lifesaving alerts before floodwaters hit in Nepal. But the concept is unproven in the field.
Eutelsat Wins Further Connectivity Business in Greenland
Eutelsat is going to help to bring better connectivity to Greenland. Alongside the European Union, the government of Greenland and the government of
Cannibalism returned to the menu multiple times in Neolithic Europe
Bones collected from three caves in Spain reveal how cannibalism came back over thousands of years.
Scientists Keep Finding the Same Mysterious Beat Across the Animal Kingdom, From Fireflies to Sea Lions
From fireflies to mammals, evolution may have tuned communication to the rhythm of neurons.
Israel to mandate Iodine in table salt amid widespread deficiency
Studies have found widespread iodine deficiency in Israel, particularly among pregnant women and children. The condition can cause thyroid problems and, in severe cases, developmental and neurological damage
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
The best gadgets and gear that debuted at IFA 2026
Why wait for the future of technology to arrive when you can see it now? Here are the most exciting gadgets from Europe's biggest tech expo.
🚨XIs ready: City visit Porto in their European opener
Estádio do Dragão is getting ready to host an electrifying UEFA Champions League opener. Francesco Farioli’s FC Porto come into it on fire after putting together seven straight wins and opening th...
🚨Confirmed XIs: Dortmund host Villarreal in their European opener
The 2026/27 UEFA Champions League kicks off in style at the mystical Signal Iduna Park. Borussia Dortmund come in as favorites, backed by three straight wins and Serhou Guirassy’s firepower up front...
'Turning blind eye' to AfD win further angers voters, analyst warns
Chancellor Merz's government must recognise the far-right AfD's victory in Saxony-Anhalt and voter discontent that led to the win, or further cement its downfall, an expert on East German politics warned.
Current events: Scientists keep close eye on Atlantic Ocean changes
The year is 2060. London shudders through months of Nordic winter freezes. Across northern Europe, oak and beech forests wither under severe frost and drought, while cereal yields collapse from temperatures ...
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Apple Acquires Startup Working on 'Breakthrough Sensing Technology'
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Legal complaint against FIFA to cover impact on women’s schedule
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Legal action against Fifa to include women's schedule
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Qualitas Energy buys Cero Generation’s 5.8GW European renewables business
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Healthcare leader urges aspiring radiologists to focus on interventional side, for fear of AI
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French A.I. Start-Up Mistral Raises $3.5 Billion as Part of Strategy Shift
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Where Is the UEFA Champions League 2026?
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Thriston Lawrence rallies from 6 behind and beats Paul Casey in a playoff in Switzerland
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EU seeks to reassure a Trump-rattled Greenland with promise of a new partnership and investment
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Champions League Is Back! TV Channels, Live Stream, Kickoff Times
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Business Rules Management System Market to Reach $4.20 Billion by 2035 as AI-Driven Decision Automation Accelerates
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Business Rules Management System Market to Reach $4.20 Billion by 2035 as AI-Driven Decision Automation Accelerates
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Dealroom.co | Jialiang Brain Science lands Series D for neurosurgery tech
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Scientists covered 200 square metres of a Swiss glacier with sheep’s wool; early tests found it protected the ice about as well as plastic sheets, but only 0.02% of Swiss glacier ice is covered
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Barcelona youngster could be handed minutes vs Feyenoord
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Ratko Mladić funeral exposes gap between Serbia’s EU ambitions and political reality
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I thought I'd regret moving to Europe, but I'm happier than ever
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EU chief unveils $232 million Greenland package
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