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Santee business owner arrested for allegedly threatening deputies

A Santee business owner was arrested this weekend after allegedly threatening to shoot sheriff's deputies who had responded to reports of gunshots, officials said.

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Apr 12 • 6:11 PM EDT • Business • 10news.com
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A $1 million Picasso is due to be sold for just $116

For the price of a dinner in Paris, somebody will soon walk away with a Picasso valued at more than $1 million.

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Apr 12 • 11:43 AM EDT • Entertainment • scrippsnews.com
Black Maternal Health Week highlights disparities, solutions at Hampton Roads conference

Held as part of the national awareness week from April 11 to 17, the conference brought together doctors, nurses, social workers and midwife advocates to address inequities in maternal health care and outcomes.

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Apr 12 • 11:26 AM EDT • Health • wtkr.com
'It was a cry for help' | Family mourns father killed in police shooting, says he struggled with mental health

The man's family asked that his identity, as well as their own, not be disclosed because they have not yet notified all of his extended family about what happened.

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Apr 11 • 10:58 PM EDT • Health • wcpo.com
Plymouth Maple Fest sheds light on the maple syrup business

People from across the Plymouth community gathered on Saturday for the annual Maple Fest, which celebrates hand-made maple syrup across Sheboygan County.

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Apr 11 • 9:11 PM EDT • Business • nbc26.com
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U.S. Small Business Administration in Helena to hear local perspective

A leader with the U.S. Small Business Administration was in Helena this week, to hear what’s on the minds of local business owners.

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Apr 10 • 10:37 PM EDT • Business • ktvh.com
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Local business owner weighs in as Louisiana blocks state minimum wage bill

For the latest session in a years-long debate, the Louisiana House Labor Committee has voted to kill a bill that would have established a $12 state minimum wage.

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Apr 10 • 7:05 PM EDT • Business • katc.com
Women's professional sports leagues see big surge in popularity and profits

Throughout the U.S. there’s been a rise in interest in professional women’s sports leagues over the past few years. According to Nielsen, in 2025 Americans watched 46 billion minutes of women’s sports.

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Apr 10 • 6:03 PM EDT • Sports • denver7.com
Maricopa County health officials confirm first heat-related death of 2026

The person is identified as a man, and no additional details, including date, time or location, will be released "to protect patient privacy," according to the department.

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Apr 10 • 6:01 PM EDT • Health • abc15.com
Science with Stevie: Spring Allergies

Meteorologist Stevie Daniels gives us some tips on how to manage the pesky seasonal spring allergies in this Science with Stevie segment!

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Apr 10 • 6:05 AM EDT • Science • wmar2news.com
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As San Diego prepares for splashdown, scientists excited about Artemis II discoveries

But once the Orion has come and gone, interplanetary enthusiasts at Scripps and beyond will still have a place in San Diego — in fact, they've been here all along.

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Apr 10 • 1:28 AM EDT • Science • timesofsandiego.com
Crossroads District businesses react to Royals stadium proposal near their neighborhood

Local business owners in the Crossroads District reacted to the city's new Royals stadium proposal two years after voters denied a sales tax extension for a downtown baseball stadium.

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Apr 10 • 1:07 AM EDT • Business • kshb.com
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Drip Bros founders giving back to the community through growing business

At a Little League game in San Luis Obispo, two young entrepreneurs are stepping up to the plate, both on the field and in the business world.

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Apr 9 • 9:16 PM EDT • Business • ksby.com
WATCH: South Phoenix businesses are feeling the heat, and it's not helping business

As temperatures rise in Phoenix, some South Phoenix business owners say the heat is keeping customers away and driving up electric bills.

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Apr 9 • 9:12 PM EDT • Business • abc15.com
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Highway ad sign costs double, pricing out Montana business owners

Sponsorship of businesses on Montana highway exit signs have doubled in cost, pricing out some small business owners.

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Apr 9 • 8:46 PM EDT • Business • ktvq.com
Zeeland restaurant sees business boost after Sunday alcohol sales allowed

For decades, Zeeland prohibited alcohol sales on Sundays. That changed a few months ago, and one business, The Gritzmaker Social House, said the new ordinance is paying off.

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Apr 8 • 10:47 PM EDT • Business • fox17online.com
City of Independence bans synthetic 7-OH, regulates kratom sold in businesses

The City of Independence voted to ban synthetic 7-OH and regulate its parent product, kratom, at Wednesday night's city council meeting.

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Apr 8 • 8:47 PM EDT • Business • kshb.com
New Virginia economic laws: Gov. Spanberger signs legislation addressing cost of living, health care

Gov. Abigail Spanberger has signed another batch of legislation into Virginia law, the most recent bills addressing cost of living and health care, according to a news release from her office.

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Apr 8 • 3:55 PM EDT • Health • wtvr.com
Preds, Scripps Sports Announce Game-Changing Broadcast Partnership

Agreement Begins Next Season; Scripps Will Broadcast Predators Games Over the Air for Free

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Apr 7 • 3:35 PM EDT • Sports • nhl.com
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Scripps Sports, Nashville Predators Partner on Multi-Year Agreement to Air National Hockey League Team’s Games

Nashville Predators, Scripps Sports Create Landmark Multi-Year Media Rights Agreement That Brings Free, Over-the-Air access to Predators Games

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Apr 7 • 3:30 PM EDT • Sports • nhl.com
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Scripps Sports, Nashville Predators Partner on Multi-Year Agreement to Air National Hockey League Team’s Games

The Nashville Predators have announced a multi-year media deal with Scripps Sports, beginning this fall at the start of the 2026-2027 season. Watching Preds games will be easier than ever, including over-the-air, cable, satellite and digital streaming. Check out the FAQs below and look for additional details to be announced this summer.

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Apr 7 • 3:30 PM EDT • Sports • nhl.com
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ASU research looks to help Valley small businesses adapt to AI

While businesses are struggling to keep up with large companies in the Artificial Intelligence boom, local researchers are working to give them an edge.

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Apr 7 • 12:31 AM EDT • Business • abc15.com
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Tariffs still challenge Brookside business one year later

Last week marked one year since President Trump's "Liberation Day" - the launch of his sweeping tariff policy. The tariffs have impacted many people across the KC metro, particularly local businesses.

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Apr 6 • 11:40 AM EDT • Business • kshb.com
Denver fans celebrate sports-filled Saturday at Stoney's with pair of thrilling victories

Colorado Avalanche and Denver Nuggets fans packed Stoney's Bar and Grill on Lincoln to celebrate a pair of thrilling victories on Saturday.

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Apr 5 • 1:03 PM EDT • Sports • denver7.com
Mulligan's restaurant in Jensen Beach is closing after 23 years in business due to high rent costs

Mulligan's in Jensen Beach is closing on Easter Sunday after 23 years. The owner cited exorbitant rent costs as the reason for the closure.

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Apr 5 • 12:29 PM EDT • Business • wptv.com
Blue-green algae sparks public health advisory at three Kansas Lakes

There is a public health advisory in place for harmful algal blooms (HABs) at three lakes in Kansas.

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Apr 4 • 1:25 PM EDT • Health • kshb.com
KU trade expert says 70% of regional businesses feel impact of higher tariffs, local flower shop is among them

A year after President Donald Trump's Liberation Day, which imposed tariffs on countries around the world, Kansas City flower shop Fiddly Fig is still navigating changing tariff rates.

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Apr 3 • 8:01 PM EDT • Business • kshb.com
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Northeast Kansas City residents push back against state-run mental health facility planned at Belvedere Park

Kansas City, Missouri, has announced plans to open a state-run mental health facility at Belvedere Park, and community members are saying it is not exactly the dream they were sold.

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Apr 3 • 6:08 PM EDT • Health • kshb.com
March job gains outshine forecasts amid inflation pressures

U.S. employers added 178,000 jobs in March, topping forecasts, as unemployment held at 4.3% and wages rose despite inflation pressures.

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Apr 3 • 8:54 AM EDT • Politics • scrippsnews.com
After more than 50 years, owners of Poor Richard's sell business

After more than 50 years of selling books, toys and pizza, the owners of Poor Richard's have sold their business.

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Apr 2 • 9:09 PM EDT • Business • koaa.com
Greektown businesses prepare for Detroit's Opening Day crowds despite ongoing construction

Detroit's Greektown businesses are gearing up for the Opening Day rush on Friday, even though the area remains a construction zone.

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Apr 2 • 5:53 PM EDT • Business • wxyz.com
'He got screwed': Former UVA Health CEO files defamation suit against lawyers over patient harm allegations

The former head of UVA Health is pushing back against allegations made by more than 30 doctors that his practices, policies, and procedures caused harm to patients.

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Apr 2 • 4:08 PM EDT • Health • wtvr.com
'We need to keep it going': Downtown Platte City sees rise in visitors as new businesses open their doors

Downtown Platte City is experiencing new momentum as a newly completed master plan aims to transform the area from a "drive-through" community into a true destination.

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Apr 2 • 7:59 AM EDT • Business • kshb.com
Historic Rock Island Bridge opens in Kansas City as new entertainment option

Historic Rock Island Bridge opens in Kansas City as new entertainment option

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Apr 1 • 12:00 AM EDT • Entertainment • kshb.com
Historic Rock Island Bridge opens in Kansas City as new entertainment district over Kansas River.

After almost a decade of planning and work, the Rock Island Bridge opens to the public at 11 a.m. Wednesday, transforming a 1905 railroad bridge into an entertainment district over the Kansas River.

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Mar 31 • 11:47 PM EDT • Entertainment • kshb.com
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New in Home Entertainment: A nature documentary, a parental comedy and an updated reality series

Screen Chatter Film Critic Tony Toscano reviews "Secrets of the Bees", "Preschool" and "Duck Dynasty: The Revival".

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Mar 31 • 3:54 PM EDT • Entertainment • fox13now.com
Why Scripps Is All In On Women’s Sports

Scripps CRO Brian Norris on why the broadcaster is leaning into women’s and local sports – and how that shift is reshaping the media plan.

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Mar 31 • 6:00 AM EDT • Sports • adexchanger.com
Shawnee proposes TIF district to help businesses near Midland Drive, I-435 impacted by construction

City Manager Paul Kramer said a TIF would help with investments in development in the district using revenue generated by it, without creating additional sales taxes on businesses.

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Mar 30 • 6:41 PM EDT • Business • kshb.com
Lextran launches new $1 LexRide seasonal bus route connecting Lexington entertainment spots

A night out in Lexington is getting easier with the launch of LexRide, a new seasonal downtown circulator from Lextran that connects popular entertainment districts for $1 each way.

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Mar 30 • 5:49 PM EDT • Entertainment • lex18.com
Lomo Meats: A local shop built on science and family roots

Samuel Garcia spent more than a decade building his expertise in meat science, working and teaching at the University of Arizona.

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Mar 30 • 8:45 AM EDT • Science • kgun9.com
Franciscan Health to host Produce Prescription Program

Franciscan Health and Indy Hunger Network have teamed up to offer the Produce Prescription Program, a six-week program focused on healthy eating options, nutrition education and support.

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Mar 29 • 9:03 PM EDT • Health • wrtv.com
Better Business Bureau program connects Marion family with trusted businesses to help finish dream home

A Marion family's dream home project hit a major setback after a contractor dispute left the build unfinished, but the Better Business Bureau is now stepping in to help them finish what they started.

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Mar 29 • 8:10 PM EDT • Business • kpax.com
Fuel price surge hits Colorado small businesses hard

Rising oil and gas prices are driving up costs for many small Colorado businesses, not just for drivers at the pump.

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Mar 29 • 5:45 PM EDT • Business • denver7.com
Annual Sugar Sand Festival brings massive hand-sculpted art and entertainment to Clearwater Beach

The annual event's theme this year features sports and American 250 sculptures, running through April 12, with the help of over 400 volunteers.

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Mar 29 • 3:39 PM EDT • Entertainment • tampabay28.com
MT AG: Ronan High School teacher brings traditional practices to science classes

A science teacher at Ronan High School is introducing traditional ecological knowledge to teach students about sustainable agriculture and land stewardship.

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Mar 29 • 9:00 AM EDT • Science • kpax.com
Cincinnati father, business owner detained by ICE; family pleads for release

A Cincinnati family is pleading for the release of a local business owner and father of two who has been held in ICE custody for nearly six weeks.

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Mar 28 • 11:22 PM EDT • Business • wcpo.com
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Homeowners petition to end the Northgate Business Owners Association

Colorado Springs homeowners petition to end the Northgate Business Owners Association, required annual fees.

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Mar 28 • 8:00 PM EDT • Business • koaa.com
The Tallahassee Arts, Science, and Theater Experience brings the community together at Railroad Square

The donation-based Taste Festival brings arts, science, theater, and local entertainment to Railroad Square to unite the Tallahassee community

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Mar 28 • 6:36 PM EDT • Science • wtxl.com
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Women's professional sports see massive growth as fans pack stadiums and viewership hits record highs

Professional women's sports are experiencing hypergrowth, expanding 4.5 times faster than men's sports.

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Mar 28 • 11:00 AM EDT • Sports • denver7.com
Source within Banks business community speaks out about impact of chaos on 'best sales day of the year'

One source with The Banks business community, who wished to not be identified, told us that the early shutdown due to massive crowds and violence greatly impacted the businesses along The Banks.

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Mar 27 • 4:38 PM EDT • Business • wcpo.com
INVESTIGATION: Jewelry business under fire after customers say they paid thousands for unfinished rings

A Cedarburg jewelry business is facing backlash from customers who say they paid thousands of dollars upfront for custom rings and never received the finished products.

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Mar 27 • 7:00 AM EDT • Business • tmj4.com
Preserving Detroit History: City awards grants to 30 long-standing local businesses

On Thursday evening, 30 Detroit legacy businesses were awarded a grant by the Detroit Economic Growth Corporation and the mayor's office.

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Mar 26 • 11:29 PM EDT • Business • wxyz.com
Colorado Springs business groups launch new networking initiative to help local business owners succeed

Local organizations are teaming up to host "4-Business After Hours," a series of events designed to connect business owners and provide resources for success in the Pikes Peak region.

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Mar 26 • 9:03 PM EDT • Business • koaa.com
Jackson County executive to announce future plans for Truman Sports Complex

Jackson County Executive Phil LeVota has called an 11 a.m. news conference Thursday to discuss the future of the Truman Sports Complex.

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Mar 26 • 9:51 AM EDT • Sports • kshb.com
As women’s sports grow, Kansas City-based group empowers women to take leadership roles

Women Leaders in Sports is a professional-development organization based in Kansas City that helps empower and connect women in or seeking leadership across the sports landscape.

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Mar 26 • 7:48 AM EDT • Sports • kshb.com
Denver’s forgotten trailblazers: The Colorado Xplosion’s lasting impact on women’s sports

The first professional women’s sports team in the Mile High City, the Colorado Xplosion, was short-lived but not forgotten.

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Mar 25 • 6:49 PM EDT • Sports • denver7.com
Belton approves development plan for Uptown Entertainment District, completion expected in 2032

The city of Belton approved a rezoning application and preliminary development plan for the Uptown Entertainment District, expected to bring 600 new homes and residents.

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Mar 24 • 8:24 PM EDT • Entertainment • kshb.com
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Billings' Daylis Stadium reconstruction 'slightly ahead of schedule'

Driving by Daylis Stadium recently, it's easy to notice a lot of dirt and all sorts of construction rigs. So, where does the renovation progress stand?

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Mar 24 • 7:36 PM EDT • Sports • montanasports.com
City says closing nuisance businesses cuts crime. Some residents question the approach

Some city leaders say shutting down nuisance businesses reduces crime, but some residents argue the closures just shift problems elsewhere.

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Mar 24 • 5:16 PM EDT • Business • wcpo.com
‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM, and the year

Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales — the second biggest ever for a non-franchise film.

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Mar 22 • 4:55 PM EDT • Entertainment • scrippsnews.com
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Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
PWHL reaches TV deal with Scripps Sports to air Walter Cup Finals to national U.S. audience in May

“Fans shouldn’t have to wait another four years to experience this level of passion, skill and drama. So we’re keeping the momentum going.”

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Mar 18 • 8:00 AM EDT • Sports • boston.com
PWHL reaches TV deal with Scripps Sports to air Walter Cup Finals to national U.S. audience in May

“Fans shouldn’t have to wait another four years to experience this level of passion, skill and drama. So we’re keeping the momentum going.”

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Mar 18 • 8:00 AM EDT • Sports • boston.com
DETROIT PISTONS PARTNERING WITH SCRIPPS SPORTS, TV-20 DETROIT TO BROADCAST FIVE GAMES OVER REMAINDER OF SEASON

The Detroit Pistons announced today that the organization will partner with Scripps Sports and FanDuel Sports Network Detroit for a third consecutive season

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Mar 17 • 9:00 AM EDT • Sports • nba.com
'Sinners' and 'One Battle After Another' poised for an all-Warner Bros. showdown at Academy Awards

The Academy Awards promises a thrilling showdown between Paul Thomas Anderson’s “One Battle After Another” and Ryan Coogler’s “Sinners,” with both directors vying for their first Oscar.

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Mar 15 • 2:02 PM EDT • Entertainment • scrippsnews.com
Boulder businesses braced for Xcel Energy's power shutoffs on Saturday

The affect of Saturday's Xcel Public Safety Power Shutoff (PSPS) is being felt in different ways by people across Boulder. Some good, others not as much.

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Mar 14 • 8:34 PM EDT • Business • denver7.com
Intermountain Health employee pleads guilty after stealing 100+ prescriptions from Colorado patients

A former employee of Intermountain Health in Colorado has pleaded guilty after she stole more than 100 prescriptions from patients being treated for significant pain.

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Mar 14 • 3:47 PM EDT • Health • denver7.com
From circles to spacecraft: How pi powers science

Math lovers and pie fans unite on March 14 to celebrate Pi, the infinite constant driving everything from space exploration to medical breakthroughs.

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Mar 14 • 12:24 PM EDT • Science • scrippsnews.com
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Cinemark bringing new Gamescape entertainment center to Corpus Christi

Cinemark is building a stand-alone Gamescape FEC in Corpus Christi with bowling, laser tag, arcade games, and dining. Opening targeted for December 2026.

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Mar 12 • 4:06 PM EDT • Entertainment • kristv.com
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PWHL to reach national U.S. TV audience with Scripps Sports to broadcast neutral site game in Detroit

The Professional Women’s Hockey League is coming to a TV set near you in the United States. The league announced its neutral-site game at Detroit on March 28 between the New York Sirens and Montreal Victoire will be the first accessible to a national U.S. television audience.

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Mar 12 • 10:25 AM EDT • Sports • mprnews.org
PWHL to reach national U.S. TV audience with Scripps Sports

The Professional Women's Hockey League is coming to a TV set near you in the United States.

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Mar 12 • 9:08 AM EDT • Sports • espn.com
ALLY AND SCRIPPS SPORTS PARTNER WITH PWHL TO DELIVER FIRST-EVER NATIONALLY TELEVISED GAME IN U.S.

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Mar 12 • 8:00 AM EDT • Sports • media.ally.com
Class B: 2026 boys and girls state basketball scores and pairings

Updated scores and pairings from the 2026 Class B boys and girls state basketball tournaments in Billings.

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Mar 8 • 12:46 PM EDT • Sports • montanasports.com
San Diego Festival of Science and Engineering draws thousands of kids amid federal funding concerns

The free event in its 18th year comes as the Trump administration proposes deep cuts to federal science agencies, including a 40% reduction for the NIH and a 47% cut for NASA.

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Mar 7 • 9:23 PM EST • Science • 10news.com
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Four more measles cases identified, Colorado Department of Public Health and Environment says

Four more measles cases were identified in the Denver metro area, the Colorado Department of Public Health and Environment announced Friday morning.

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Mar 6 • 12:12 PM EST • Health • denver7.com
A little butter and a lot of passion: Black Box Bakery perfects the recipe for a successful small business

Black Box Bakery opened in the Edgewater Public Market and has quickly become known as one of the top bakeries in the Denver area. How did they do it? With professionals who take pride in their work.

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Mar 6 • 12:29 AM EST • Business • denver7.com
Clinton County teen dies from flu, health district announces

In a release, the Clinton County Health District provided no immediate details, only saying that 'our thoughts are with the family during this incredibly difficult time.'

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Mar 4 • 5:43 PM EST • Health • wcpo.com
Riley Children's Health families concerned about parking prices

The standard daily rate for Riley's outpatient garages is $18, and as of March 1, all outpatient parking is available at the discounted rate of $5 per day.

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Mar 3 • 10:33 PM EST • Health • wrtv.com
Scripps Oceanography at UCSD granted $15M for deep sea, glacier science

The Fund for Science and Technology, a new private foundation, granted Scripps Institution of Oceanography at UC San Diego $15 million for ocean science Tuesday.

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Mar 3 • 5:55 PM EST • Science • nbcsandiego.com
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UL Lafayette political science professor weighs in on Iran conflict

A local political science professor says the escalating tensions in the Middle East could carry international and domestic implications, but warns that talk of a wider global conflict is premature.

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Mar 2 • 7:01 PM EST • Science • katc.com
Fund for Science and Technology Awards $15 Million to Scripps Oceanography

Scripps Institution of Oceanography at the University of California San Diego has received a $15 million grant from the Fund for Science and Technology. This support will expand observational capabilities into parts of the ocean where data has historically been sparse or nonexistent.

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Mar 2 • 7:00 PM EST • Science • today.ucsd.edu
Ilitch launches Detroit SportsNet for Red Wings & Tigers broadcasts; here's how much it will cost

A new Detroit sports channel will broadcast Detroit Tigers games for 2026, and next season's Detroit Red Wings games.

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Mar 2 • 12:11 PM EST • Sports • wxyz.com
Impression 5 Science Center's LEGO Palooza fundraiser supports hands-on learning for kids

Thousands of LEGO bricks came together over the weekend at Impression 5 Science Center in Lansing for the annual LEGO Palooza fundraiser.

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Mar 2 • 6:23 AM EST • Science • fox47news.com
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Political Science professor warns of long-term economic fallout from US attack on Iran

A Park University political science professor says Americans likely won't feel the full consequences of the recent U.S. military attack for months down the road.

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Feb 28 • 5:30 PM EST • Science • kshb.com
WATCH: Rocky Point businesses prepare for spring break and other vacations

After what was a chaotic weekend in Jalisco and parts of Mexico, businesses in Rocky Point say they remain relatively unaffected even as customers call to make sure they are still safe to travel.

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Feb 27 • 12:05 AM EST • Business • abc15.com
Company accused Virginia health inspector of 'bias' as nursing homes received serious violations

Internal communications obtained by CBS 6 revealed allegations that a Virginia healthcare facility inspector was biased against a particular group of nursing homes.

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Feb 25 • 2:43 PM EST • Health • wtvr.com
Historic Berkley Theatre building to become live entertainment venue

The building that once housed the Berkley Theatre is being transformed into a $4 million live entertainment venue.

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Feb 24 • 8:20 PM EST • Entertainment • wxyz.com
The University of Kentucky provides Updates to proposed entertainment district

The University of Kentucky has released four options for a proposed entertainment district that would surround Kroger Field.

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Feb 24 • 5:20 PM EST • Entertainment • lex18.com
Chris Powell aims to transform the health of the country and beyond with 'TransformNation'

Appropriately titled, "TransformNation," the free YouTube series debuted a few weeks ago and has already seen huge success.

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Feb 24 • 7:04 AM EST • Health • abc15.com
Colorado lawmakers consider a bill to boost small businesses through a loan program

State lawmakers are considering a new bill (HB26-1003) aimed at helping more small businesses across Colorado.

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Feb 23 • 8:11 PM EST • Business • koaa.com
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Colorado Springs man discovers business using his home address without permission

A Colorado Springs man is sharing his story after he discovered someone registered a business to his home address without his permission.

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Feb 21 • 11:01 PM EST • Business • koaa.com
Woodland Park business forced to close after mold contamination discovery

Hunt & Homestead Marketplace in Woodland Park closes due to mold contamination as owner proposes new landlord safety requirements to city council.

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Feb 21 • 9:30 PM EST • Business • koaa.com
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Colorado small business owner reacts to Supreme Court tariff ruling

Denver7 followed up with the owner of Outdoor Element, a business to help campers and hikers explore with confidence, after Friday's Supreme Court tariff ruling.

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Feb 21 • 12:12 AM EST • Business • denver7.com
Minority business owners highlight community and culture in Great Falls

Minority groups often have unique experiences when moving somewhere new and for Black History Month this year we’re talking to some of our community members on their experiences in Montana.

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Feb 19 • 5:38 PM EST • Business • krtv.com
Johnson County small businesses shared tariff concerns with Rep. Sharice Davids

Small business owners in Johnson County are facing mounting financial pressures as tariffs drive up costs for essential supplies, forcing them to make difficult business decisions.

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Feb 18 • 10:42 PM EST • Business • kshb.com
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Here's how the new Portage Crisis Center hopes to bridge the mental health care gap

Where should someone go if they're dealing with a mental health crisis, needing the security of a jail but the care of a hospital?

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Feb 17 • 5:07 PM EST • Health • news5cleveland.com
Two Armed Men Rob Billings Business, Investigation Ongoing

Billings police are actively investigating an armed robbery that occurred overnight in the city's west end.

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Feb 17 • 2:59 AM EST • Business • ktvq.com
Lakewood expands safety and security grants to all businesses in the city

Reimbursements for safety upgrades between $2,500-$5,000 are available for eligible businesses and projects

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Feb 16 • 7:45 PM EST • Business • denver7.com
Survey: Small business owners show cautious optimism about economic health in 2026

Small business owners are expressing cautious optimism about 2026, with new survey data revealing companies are increasingly investing in equipment and facilities at levels not seen since late 2023.

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Feb 16 • 2:55 PM EST • Business • kshb.com
Daygo Eatz celebrates Black-owned businesses during Black History Month

This Black History Month, San Diego is highlighting community events including Daygo Eatz, an annual celebration that brings taste, sound and fun to Imperial Avenue.

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Feb 15 • 10:12 PM EST • Business • 10news.com
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