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Draymond Green's Klay Thompson Defense Reveals Miami Heat's Promising Plan
Draymond Green's defense of Klay Thompson offers a useful blueprint for Miami Heat expectations. Thompson's role should center on shooting gravity, off-ball movement, and complementary offense-not recreating his 2017 Golden State Warriors production. Green's Ray Allen comparison reinforces that approach after Thompson's move to Miami. What Did Draymond Green Say About Klay Thompson and the […] The post Draymond Green's Klay Thompson Defense Reveals Miami Heat's Promising Plan appeared first on S
Revolut takes aim at business banking with FTSE 250 companies
Fintech’s business division has a target of 1mn customers globally by 2027
Actor Says Theatre Fired Him from “Bright Star” Over His Adult Entertainment Past
An actor says he was fired from an upcoming production of Bright Star just before rehearsals began after the theatre learned about his past work in adult entertainment.
Ram Getz & Michael Mortensen Launch i80 Entertainment (EXCLUSIVE)
Ram Getz and Michael Mortensen, partners at GM Management, have launched i80 Entertainment, a new independent production company.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
Tulsa Fire Department marks 10 years of mobile health care
The program helps Tulsans address health needs before they become 911 emergencies, with clients seeing major reductions in emergency calls.
Disney On Ice coming to Mohegan Arena next year
WILKES-BARRE TWP., LUZERNE COUNTY (WBRE/WYOU) — A new Disney On Ice production is skating into the Mohegan Arena in January 2027. Disney On Ice presents Spotlight Magic! Coming to the Mohegan Arena at...
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
BUSINESS Katie Scheuber showcases their unique storytelling with Stay Tuned Productions
Almost 12 years ago, nonbinary lesbian Chicago documentary filmmaker and photographer Katie Scheuber created Katie Makes Films video, a production company to showcasing their love of visual storytelling, while still working as a social worker. In 2022, Scheuber’s wife Noemi Heras encouraged them to do the video work full time. Last year Scheuber created Stay Tuned […]
Why Life’s Origin Can Only Be Explained by Design
The reagents of the feedstock are never produced by processes as on the early Earth. Production requires substantial energy and controlled industrial procedures
More Americans Are Losing Health Insurance—And Everyone Will Pay
As people lose health insurance coverage, experts warn of more crowded hospitals and higher costs for everyone.
Disney’s “Aladdin” reveals first woman to play Genie on Broadway — and she’s a famous former“ View” cohost
“Aladdin” in New York City will host the first woman to ever play the Genie in any of the 11 Disney-produced productions of the show around the world.
Tobacco use can undermine fertility, UN health agency warns
Smoking very likely makes it harder to have a baby, the UN World Health Organization (WHO) warned in a new publication issued on Tuesday, highlighting that women who smoke have a 40 per cent higher risk of infertility compared to non-smokers.
Eerily humanlike AI-powered robot enters mass production in China — its makers say it could soon be helping you out at home
Xpeng's engineers have designed a humanoid robot that they say is the first in the world that will walk itself off the production line.
Illinois’ efficient offense compensated for dodgy defense
The Illini offense will need consistent production while the defense adjusts to a new scheme.
Science Spotlight: AI could be 'pivotal' in eco-innovation for beauty
Artificial Intelligence (AI) technologies can help beauty companies accelerate eco-innovation from start to finish, aligning efforts to key United Nation sustainability goals. According to a review published in Cleaner Production Letters, however, use of AI to drive sustainable cosmetic innovation remains underexplored. Up until now, the integration of AI into the cosmetics industry has “predominantly focused on personalisation, marketing, and supply chain optimisation,” the researchers...
Kerry Yu Achieves Recognition for Expertise and Contributions to the Field of Fashion, Modeling, and Entertainment Production
September 8, 2026 -- Kerry Yu recognized for 30 years in fashion design and apparel management
David Andrew Goodman is Celebrated for Decades of Continued Success in the Entertainment Sector
September 8, 2026 -- David Andrew Goodman is lauded for his contributions in production lighting at Goodman Grip & Light
The AfD Is Rising. Germany’s Political Center Is Failing.
"The Alternative for Germany built its nationwide constituency through relentless opposition to immigration, nativist appeal, and efforts to relativize Germany’s Nazi past," write Sudha David Wilp and Jackson Janes.
Tim Schafer: "No one puts Double Fine out of business except me"
Studio boss discusses regaining independence after leaving Microsoft, and navigating the current industry landscape
‘Here There Are Blueberries’ heads to Broadway, Rupert Grint returns in ‘Cursed Child’ and more theater news
"Here There Are Blueberries" and other productions are headed to Broadway and theater in New York City.
Property tax cap hurts school district revenue, GFPS business manager says
The 3% cap could mean $300,000 less in local revenue.
Advancing manufacturing through a trusted partnership
Learn how a contractor and Cleveland-based manufacturer partnered to modernize the production, improve efficiency and support future growth.
CT beer maker pours $650K into new brewhouse, eyes further expansion amid wholesale growth
Nod Hill Brewery invested $650,000 in its Ridgefield operation as wholesale sales rise, with plans to boost production capacity by 2028.
Jayden Savoury Has Announced Himself as MSU’s Top Tight End
The Orchard Lake product transformed offseason hype into on-field production, emerging as Alessio Milivojevic’s vital security blanket while providing a new, physical dimension to the Spartans' passing attack.
John Ternus’s first test at Apple: selling a $2,000 foldable iPhone
Smartphone maker needs to raise prices across its device range to make up for rising costs
3 Steps to Support Mental Health for Rural Youth
(Feature Impact) Young people face a growing number of pressures, including academic expectations, social responsibilities, complex family situations and uncertainty about their own futures. Mental health support is important for all - but in many rural areas, those pressures are even greater. If the rural mental health crisis affects you or a loved one, consider these ways to help.
From masters in management to mental health start-up
Study story: Healthcare entrepreneur Julia Néel Biz applied lessons and connections to build a business
Doubts damp demand for business courses in the ‘Anglosphere’
Immigration policies, inflation and uncertain job markets have reduced appetite for study in the UK, US and Canada
White Voters Are Twice as Likely as Black Voters to Follow Politics Closely
We asked voters how closely they follow government and current affairs, and we have the answers, visualised just for you.
Europe wants to build with Ukraine. Can its defence industry keep up?
As Kyiv pushes Europe to move faster, its defence industry is showing just how far behind the bloc still is
Robert Pattinson Is Disturbing and Alluring in Primetime, a Sordid Movie About a Sordid TV Show
Pattinson plays 'To Catch a Predator' host Chris Hansen in Lance Oppenheim's first narrative feature film.
Letter: How de Gaulle doesn’t fit modern political templates
From Smith Rothchild, Seattle, WA, US
Letter: Science Museum is wrong to ‘capitulate’ to activists
From Sir John Rose, Former Chief Executive, Rolls-Royce PLC, London SW11, UK
The science behind the beauty business
Some of Europe’s industrial champions may be in retreat, but its cosmetics sector remains a global leader, buoyed by healthy demand, recognised brands and a reputation for innovation."The fact is, the science in cosmetics is better here in Europe than anywhere else in the world,” says Pierre Morvan, CEO of Technature, a private label cosmetics manufacturer located near Brest in France’s northwestern Brittany region. “You have to have good science in order to make the difference, and that is why we invest so much in research and innovation.”Across Europe, the beauty and skincare products sector supports an estimated 3.6 million jobs, including 265,000 employed directly in the industry, according to the Cosmetics Europe trade group.. Cosmetics production contributes an estimated €11 billion to the EU economy, and generated €30 billion in export revenue last year, a €400 million rise from 2024.Technature itself has a global footprint, supplying products for 1,500 brands in 65 countries. Its range of skin gels, facial masks, nail treatments and other products include natural ingredients and extracts derived from plants, such as seaweed, that are developed and refined through science-based analysis and testing.While industry projections point to sustained growth for the foreseeable future, driven by emerging economies and wider availability of exclusive brands that were once chiefly sold by high street retailers, the sector is not immune to the impact of geopolitics and trade wars. The Trump Administration’s tariff threats have dented cosmetics exports to the EU industry's largest overseas market. After the European Parliament approved the EU-US Turnberry Agreement in June, setting a 15% levy on many EU goods, the French Federation of Beauty Companies warned that “exports are falling sharply” and urged the EU to negotiate an opt-out for cosmetics.Technature’s CEO flags South Korea as an emerging competitor, partly due to its assertive marketing efforts. “I would have to say I am a little bit scared,” Morvan says, regarding the growth potential of the South Korean cosmetics industry. “This is why science and innovation are so important if Europe is to remain the leader.”With a workforce of 200, including biologists, chemists and other scientists, around 15% of Technature’s staff work in three research and development (R&D) labs. A similar number work in four quality control and assurance facilities, where science plays a crucial in ensuring product safety in a sector that is subject to the European Cosmetics Regulation.Educational exchange between industry and academiaIn recognition of Technature’s research and innovation, Morvan was selected as one of Brest’s ambassadors to Science Comes to Town (SCTT), a European initiative to strengthen communications and understanding between science and society. Brest is one of three coastal cities in the EU-funded programme, alongside Split (in Croatia) and Kiel (in Germany). From 7-11 September, Brest will host the EU TalentOn contest featuring 100 early-career researchers from across Europe.Morvan appreciates the value of engagement with educational and scientific institutions as well as the home community. For instance, Technature collaborates closely with university partners to enhance its in-house R&D. In addition, it invites students to its labs and sends its own researchers to local institutions. "We absolutely want the students to know what the industry is all about,” Morvan says, noting that seeing science in action can help young people “understand that they can do something real with science, to create something with what they are learning.” He says another important benefit: encouraging new generations of young people to consider a career in cosmetics.Community involvement also raises awareness about Technature and the skincare industry as a whole. “The public gains recognition of the innovative company that we are, and this is important for getting new customers,” Morvan says. One of its recent innovations — tiny, colourful cosmetic pearls that release skin moisturisers on application — was showcased at this year’s VivaTech event in Paris.Morvan holds a master's degree from the Brest Business School and studied animal production and biology in Brest at the University of Western Brittany (UBO), an SCTT partner, and at the University of Tours. He got his start in business in 2002, initially working on using seaweed as a raw material in the food industry before transitioning to cosmetics. Morvan has always been interested in connecting science and business, reflecting one the goals of SCTT to enhance public-private collaboration.The invitation to participate in SCTT was unexpected. “It was a surprise to get a call from the city of Brest saying that they wanted me on this programme,” Morvan recalls, adding that officials were drawn by his company’s R&D. “It's not only theory and science fundamentals. Our science is something that is applicable to the global market — and important for the community.”Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Report: New Killzone Project in Very Early Stages of Production
Guerrilla Games alongside an external studio is working on a new Killzone project that's either a remaster/remake.
What’s filming now in Georgia: ‘Will Trent,’ new Dennis Quaid show, more
Georgia film and TV production activity remains in relatively modest gear.
Can Arvell Reese win DROY without traditional edge rush production?
New York Giants LB Arvell Reese is an early DROY candidate, but can he win the award without traditional edge rush production?
Presidio’s Resonate uses agentic AI to turn sports archives into searchable inventory
Presidio is pairing Captivate and Resonate to automate tagging, retrieval, and clip creation on AWS Media Lake, aiming to speed monetization and production work
California moves to protect 35,000 film and TV jobs with new legislation
California lawmakers introduce AB/SB 186 to protect film and television production jobs in the state. The bill addresses unintended impacts of SB 122 tax legislation on the Film & TV Tax Credit Program.
‘Unfinished business’: Travis Kalanick revisits robotaxis with new start-up
Atoms gears up for hiring spree and could link with Uber, the company he was ousted from almost a decade ago
Sony clarifies PlayStation disc production is dropping by 10 percent in 2028, not to 10 percent
Sony has clarified that PlayStation disc production is dropping 10 percent in 2028, not to 10 percent, after reports misread comments from a Sony DADC exec.
Essentia Health-St. Mary's Medical Center welcomes emergency medicine specialist Dr. Jordan Ensz
Dr. Jordan Ensz, an emergency medicine specialist, is thrilled to join Essentia Health-St. Mary’s Medical Center.
Essentia Health-St. Mary's Medical Center welcomes hospitalist Dr. Samuel Boderman
Dr. Samuel Boderman, a hospitalist, is thrilled to join Essentia Health-St. Mary’s Medical Center.
Essentia Health-Duluth Clinic welcomes nephrologist Dr. Hannah Kruger
Dr. Hannah Kruger, a nephrologist, is thrilled to join the Essentia Health-Duluth Clinic.
Essentia Health-St. Mary's Medical Center welcomes emergency medicine specialist Dr. Jordan Stipek
Dr. Jordan Stipek, an emergency medicine specialist, is thrilled to join Essentia Health-St. Mary’s Medical Center.
Essentia Health-Lakewalk Clinic welcomes Chris Senger to practice sleep medicine
Chris Senger, a certified physician assistant practicing sleep medicine, is thrilled to join the Essentia Health-Lakewalk Clinic. He has spent more than three years working in family medicine at Essentia, and is excited about this new role.
Essentia Health-Duluth Clinic welcomes physiatry specialist Dr. Christine Tenhoff
Dr. Christine Tenhoff, a doctor of osteopathic medicine specializing in physiatry, is thrilled to join the Essentia Health-Duluth Clinic.
Patriots Add Intriguing Defensive Back In Latest Practice-Squad Change
Elliott Davison’s ball production and special-teams potential make him an intriguing developmental addition to New England’s practice squad.
Movie studio, amusement park planned for huge site near Phoenix
A prominent local real estate investor has unveiled a plan for a development an hour west of Phoenix that could include a movie production studio.
We Need a Cure for AI Health Hype
AI evangelists’ bold predictions about the technology’s ability to cure all diseases are overblown and oversimplified, writes Arianna Huffington.
Will a Turnaround Plan Revive Volkswagen or Merely Delay Its Demise?
The beleaguered auto giant reached a deal with unions to cut tens of thousands of jobs and slash production. Is it enough to revive an iconic German company?
From ‘slop’ to prime time: how AI dramas are shaking up China’s TV industry
Fully AI-generated, 30-episode Journey to the West series debuts, as shifting production economics transform the industry.
Lack of Center Depth Could Lead to Disaster for 76ers
Joel Embiid will be healthy to start the season. If he doesn't make it through the season, the 76ers will have a hard time replacing his production.
Should the Miami Heat Have Aggressively Pursued Ben Simmons?
As Sacramento gambles on the former All-Star, the Miami Heat's championship-caliber roster avoids the risk, prioritizing established veterans over a reclamation project with declining production and immense pressure.
‘There’s a desire to see steadiness’: Healey sounds pro-business note as he talks up growth
UK chancellor refuses to rule out higher taxes on banks in his first Budget, but tells FT he will press ahead with City deregulation drive
New pancreatic cancer drug could add to employers’ health bills
Rasonque’s approval is an exciting development in the fight to cure cancer, but could further challenge employers to carefully manage use.
Pelosi, Omar join Trump and Schiff as unlikely alliance pushes to onshore key industry
Adam Schiff, Nancy Pelosi and Ilhan Omar back Donald Trump's federal film tax incentive to bring movie production back to California and America.
Arizona Land Consulting Eyeing W. Phoenix for Massive Entertainment-Themed Development
Arizona Land Consulting revealed plans for a development west of Phoenix that could include a movie production studio, amusement park, hotels, retail and a data center campus. The Phoenix Business Journal reports roughly 900 acres off Interstate 10 and 411th Avenue have been set aside for the development, with costs estimated between $6 billion and ...
Sony Factory Will Still Have Significant PS5 Disc Manufacturing Capacity After Physical Media Deadline
Production will decline by 10%, not to 10%
Minister MacDonald announces support to advance swine health surveillance in Canada
Canada's pork industry is an economic powerhouse. Recognizing that infectious disease is one of the major risks to swine production, the Government of Canada is helping industry further develop the tools needed to safeguard animal health, strengthen sector resilience, and support future growth.
Executive Liquidates 2,900 Shares of Entertainment Stock, Valued at More Than $525,000
Capo's $534,000 liquidity event reduces his direct stake by 25%, leaving him with $1.6 million in remaining holdings as the stock maintains momentum.
Markey, Massachusetts and the limits of generational politics
Might age and incumbency matter less than a candidate’s policy platform?
Celebrating the 2026 Prairie Business 50 Best Places to Work
Nearly 1,400 nominations were submitted for more than 75 companies
Sony's PlayStation disc plant is losing 10 percent of its volume in 2028, not 90
Sony’s PlayStation disc plant is losing 10 percent of its volume in 2028, not 90 Sony won’t license disc pressing to anyone else, Microsoft does, and a former PlayStation boss thinks that’s the whole problem. When Sony DADC chief Dietmar Tanzer spoke with an Austrian broadcaster in July about PlayStation disc production at the Thalgau plant, a number of press outlets misunderstood the report, writing that production would fall to a tenth of current levels. It won’t. Sony DADC confirmed to Game this week that the figure is a 10 percent decline, not a decline to 10 percent. “To clarify and avoid any misleading information: in that statement Dietmar anticipated an overall product volume decline by 10 percent, not a decline down to 10 percent,” a spokesperson with Sony DADC told Game. That figure covers 2028. Tanzer didn’t put a number on the years after, and the spokesperson declined to comment further. What we do know is that on July 1, PlayStation announced that physical game disc production for all new games releasing on PlayStation consoles will be discontinued starting January 2028 and that the transition has no impact on games that have already released in disc format or will be releasing in disc format prior to that month. “So, there will be reorders going to the market after January 2028,” the Sony DADC spokesperson said. “For details around that I would ask you to liaise with the PR team from PlayStation, as we can’t speak or comment on their behalf.” PlayStation officials did not respond to questions about reorders or other disc-related matters. But I did recently speak with Shawn Layden, Game Industry Strategic Advisor and former chairman of SIE Worldwide Studios, who called a future without physical PlayStation discs “depressing, but solvable.” then added, “I think.” The chief hurdle to third-party manufacturing of collector’s editions or any other version of a PlayStation game disc is that Sony owns the proprietary process to press those discs, Layden said. “And unless they decide or determine a way to license that to some of these bespoke disc manufacturers, there’s no way to make it happen,” he said. Layden was careful to add that he understands the concept but doesn’t have “line of sight on the particulars.” “Depressing but solvable, I think.” — Shawn Layden Microsoft already licenses replication to outside plants. Xbox discs are pressed by manufacturers Microsoft certifies as Authorized Replicators, a term defined in its publisher agreements, with the approved list set at the company’s sole discretion and Microsoft retaining the right to halt manufacture. The structure is still in place today: publishers select an Authorized Replicator in Partner Center and submit a bill of materials created with a Microsoft representative. Sony, by contrast, presses PlayStation discs through Sony DADC, its own manufacturing subsidiary. No one I spoke with said they were in discussions with Sony about doing that, and PlayStation hasn’t responded to questions about whether it would be open to a licensing deal. There is an obvious reason Sony might not want to. Niko Partners analyst Daniel Ahmad pointed it out on the day of the announcement: it’s a platform-led decision, he wrote, designed to cut costs, eliminate the resale market, and drive all revenue through the PlayStation Store. The math is not subtle. On a $70 third-party game sold through the PlayStation Store, Sony keeps $21. Sold at retail, Ahmad says, it earns about half that. Licensing disc replication to an outside manufacturer might not be worth it. And even if it were, it seems unlikely that such a deal would come from boutique companies like iam8bit, which sells collector’s editions of video games. “We would absolutely love to find a way forward to continue making physical PlayStation games,” said Jon Gibson, co-owner and co-creative director of the company. “We are big believers in giving humans the option to truly own media. If we can play a role in helping make that a reality for the future of PlayStation games, count iam8bit in!” If it were to happen, it would most likely be with a company like Conectiv Supply Chain Solutions, a Memphis-based manufacturer of optical discs and vinyl records that also runs third-party logistics, fulfillment and distribution for packaged media. The company, which was formed in 2025 when Los Angeles private equity firm Variant Equity Advisors purchased Vantiva’s Supply Chain Solutions division, traces its lineage back to Technicolor. When it sold the division, Vantiva described the business as having served video game creators for more than 25 years. Conectiv is also buying, not shrinking. Last month it acquired SDS, the distributor for Universal and Warner Bros. home entertainment, consolidating those studios’ packaged-media pipeline from pressing plant to retail shelf. I reached out to Conectiv and its CEO, but haven’t heard back. Layden pointed to music and books in our discussion about the ongoing value of physical media. “No one ever saw the comeback of cassette tape,” he said. “And vinyl didn’t so much come back. The flame went down, the fire’s dying, but the ember was always there, and it just kind of came back. Much like the book business. We thought we’d all be on Kindles right now. “I believe that physical media is crucial and important. One of the things that makes us gamers, one of the core game mechanics, going back to the beginning of time, is collecting stuff. “Did you get all the diamonds in Crash Bandicoot? Did you get all the stars in Mario? And we like to collect our games. And we have a game shelf. And we put all our boxes up there. And if you’re super hardcore, when you buy a game, you buy two copies, right? One stays in the shrink wrap, and you play the other one. What happens to that important cultural part of the gaming world? You know, we buy the steelbook and the three-disc Final Fantasy set and the figurine and, you know, you can’t download any of that. “What happens to that?” And Layden believes it shouldn’t have been a revenue question for PlayStation. “This was a core thing to the experience of our most devoted fans,” he said. “Yeah, it’s fan service. Why would we take that away? Well, we can’t afford to. It’s already 120 bucks, you know, limited edition special purchase onyx box version of whatever, and those sell at a higher rate than the box selling at $69.99 does. So yeah, the market has said they will continue to buy them. You’re just saying you just don’t want to make them anymore.” Layden said he was recently talking with someone about these sorts of business decisions and how they’re made. Too often, he said, it’s all about the financials and nothing else. “OK, we can do this and save this much money, or we can invest this to look at that outcome, or we can do this and have this happen over there, or move this team to Sri Lanka,” he said. “But each one of those, someone also has to have a ledger there saying, ‘OK, what is the brand impact from that move?’ “Iif you can’t resell it, do you really own it?” — Shawn Layden “If we do that, dollars and cents work out. I get it. That’s just math. But what’s the brand impact? Are people going to say, ‘Good move, you guys?’ Or are they going to say, ‘We hate you guys. Quit doing that.’ And sometimes they say, ‘We hate you.’ Then you take a note and say, OK, how much of that can we live with? How much ‘we hate you’ is OK. And when does it go over the line? “I see a lot of companies making decisions which, objectively speaking, I don’t know what the dollar end of that was for you, Mr. Company, but your brand value just dropped 30 percent. So I hope it was worth it.” Of course, shifting to a digital-only model for games raises other issues beyond simply wanting to collect. The biggest is ownership. Layden pointed out that once you go to a streaming-only or download-only model, it’s just a digital footprint on a hard drive. “What does ownership mean anymore?” he said. “It’s a genuine question. Well, in fact, it’s not even a question anymore. It’s like you are shifting the model from ownership to accessibility. “And what’s always been true, which people forget, is you’ve never been able to sell your iTunes library. And you can’t sell your PlayStation download library. So if you can’t resell it, do you really own it?” The touching tribute found in the credits for Star Wars Zero Company. Resonance: A Plague Tale Legacy Interview and Hands-On with a Minoan Masterpiece Star Wars Zero Company hands-on: Attack Astromechs, permadeath, and delightfully fatal Rube Goldberg tactics Control Resonant opens up as you get stronger — and as characters start trusting you
iPhone Ultra Production Hitting Just 'a Few Hundred' a Day, Says Nikkei
Apple last month only managed to produce "a few hundred units a day" of its upcoming foldable iPhone because of the company's extremely high quality control standards, according to Nikkei Asia ($), citing supply chain sources. From today's report: "Production is ramping up slowly, with output currently at only a few hundred units a day in late August.
KFile: Swing-seat Democrat deleted posts envisioning ‘a world without police and prisons’
William Lawrence, the Democratic nominee in one of the country’s most competitive House races in Michigan, deleted hundreds of old social media posts in which he embraced police and prison abolition, called for nationalizing fossil-fuel companies to end their production, attacked moderate Democrats and argued for a “fundamental overhaul” of the Constitution.
End of the world: Scientists reveal 7 countries most likely to survive a global collapse by maintaining society and food production
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Philadelphia Reporter Doesn't Believe Eagles' Makai Lemon is Ready
As the Philadelphia Eagles prepare for the first game of the season, the biggest question remains: what will they do to replace AJ Brown's production? I think one thing that people are forgetting is that the Eagles not only have to replace Brown's production with DeVonta Smith, but they also need to replace Smith's production. Smith is going to be the WR1, and rightfully so.
Olmsted County public health advisors hear from tobacco industry rep
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Bears need health, production from WR Rome Odunze to form dynamic duo
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Hammer Realty celebrates 50 years of family-owned business in Wahpeton
Third-generation owner Jessie Hammer carries on her family’s legacy while looking toward the future of the local real estate company.
'Soiled' undies and vicious friends research honoured at Ig Nobels
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Weekend Entertainment | ‘The YO’ Film Puts City at Center of the Extreme Sports World
A good question to ask when watching a locally made movie is, would anybody outside of Youngstown want to watch this? Of course, the story or narrative, the cast, and the production quality also have to be of the highest quality. The latest offering from a Mahoning Valley filmmaker easily checked all of those boxes […]
Carencro oil & gas business plans to tap into SpaceX development
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Anthony Richardson is the Colts' No. 2 quarterback
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The Athletic finally publishes its internal review of Dianna Russini
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Cherokee Film brings music to life via cutting edge technology
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Entertainment platform aTwist launches with microseries as Hollywood chases mobile viewers
Microseries platform and studio aTwist launched on Thursday with 10 original series and curated library content, as shifting entertainment preferences drive a wave of demand for mobile-first short-form storytelling.Microdramas are gaining popularity as Hollywood production shrinks and streaming com…
Look out, Hollywood. Influencers are taking over Burbank
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Former NFL CB Alphonso Smith Jr. dies at 40
Alphonso Smith Jr., a former NFL cornerback and the 37th overall pick in the 2009 draft, has died.
Business school teaching case study: Can you put a price on impact?
Brazilian cosmetic company Natura attempts to put a monetary value on the social, human and environmental effects of its activities
Graduates weigh business study now against a later MBA in tough job market
People who might have worked before business school are increasingly looking to an immediate masters in management
Police make arrest in attempted break-in at Saquon Barkley's home
In July, someone attempted to break in to Eagles running back Saquon Barkley's Philadelphia-area home.
Republican Senator Calls On Trump to Replace Defense Secretary Pete Hegseth
Sen. Thom Tillis is urging the President to oust Hegseth because of what he described as “inept management.”
Repression of political opposition surges in post-election Zambia
Following Zambia’s contested presidential and parliamentary elections almost three weeks ago, the crackdown on political opposition has intensified, raising concerns about the future of democracy in the country, according to a UN Human Rights Council-appointed expert.
Inside Camelback Productions’ Plans for an AI-Powered Production Space
Anita Verma-Lallian wants to build a sprawling 1,400-acre complex off the I-10 in Arizona.
Inside Camelback Productions’ Plans for a New 1,400-Acre, AI-Powered Production and Entertainment Complex
Anita Verma-Lallian, founder of Camelback Productions, doesn’t see the future of film production in Los Angeles. Instead, in her vision, it is on a complex one hour’s drive west of Phoenix, complete w...
SPIRITED AWAY: LIVE ON STAGE Joins Fathom Entertainment’s Studio Ghibli Fest 2026
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NOAA Fisheries Outlines Science-Based Reforms to Boost American Seafood Production
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Raiders officially name Kirk Cousins their starting quarterback
Cousins will officially begin the season as Las Vegas' QB1 over rookie Fernando Mendoza.
New literacy law brings science-of-reading training to hundreds of…
Oklahoma is beginning to implement a major overhaul of its approach to reading instruction after years of dismal literacy outcomes, with hundreds of…
Chevron expands Venezuela position, to invest $7 billion in next five years
Chevron said on Wednesday it had agreed with Venezuela on updated terms for its joint ventures in the country and plans to invest more than $7 billion over the next five years, targeting production of about 600,000 bpd.
August Monthly Review: ChatGPT In Epic
Death, taxes, another frontier lab healthcare launch inspiring truly insane LinkedIn takes. As much as I want to stay away, I repeatedly am the crewman unplugging his ears whenever we pass these sirens. So it’s not the first and probably not the last time we dial up the typewriter rather than tie ourselves to the mast. The full blow-by-blow timeline: Health API Guy is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe The End of the Standalone PHR (Jan 8): ChatGPT Health arrives for consumers, at the time powered by b.well. I was bullish on the approach in that the best way for the PHR to finally solve distribution was to meet consumers were they already are (i.e. When Horizontal Meets Healthcare (Jan 9): OpenAI for Healthcare puts out the shingle for enterprises, with SharePoint ingestion standing in for the EHR integration the product actually needed. Another One: Anthropic’s Healthcare Debut (Jan 16): Claude's version, on HealthEx rails instead of b.well, with Agent Skills for FHIR development as the one true vertical-specific investment. ChatGPT for Clinicians: The Trap Sprung (Apr 24): OpenAI filled in the missing GTM middle with a free product for verified clinicians, effectively peeling the enterprise wrapper off ChatGPT for Healthcare and taking the PLG fight directly to OpenEvidence. OpenAI’s Second Attempt at Health (Jul 31): a relaunch of their patient specific app, now branded Health in ChatGPT, where the privacy partition came out, the connectors thinned, and b.well disappeared in favor of first-party FHIR work against a smaller network Beyond a Shingle So what was announced now? Today, we’re introducing a new electronic health record integration that brings authorized patient context from Epic into ChatGPT for Healthcare, along with the Healthcare Public Data plugin for direct, structured access to official healthcare datasets like PubMed, DailyMed, and CMS Coverage. Together, these capabilities bring ChatGPT closer to the systems and sources healthcare teams trust, while supporting the controls and compliance healthcare work requires. The core portfolio is unchanged from prior announcements we delineated and discussed (aside from the relaunch of patient-facing). Since trade publications still seem to be confusing them by using the wrong names: Enterprise sales motion: ChatGPT for Healthcare Protecting their core product / PLG: ChatGPT for Clinicians Consumer/patient-facing product: Health in ChatGPT So really, this is a feature release (specifically for ChatGPT for Healthcare when it comes to EHR integration). What’s cool about it, though, is that we are moving beyond just putting out a shingle. Everything in the January enterprise launch was horizontalizable: Horizontal tech companies thus generally start verticalization with their “putting out a shingle phase”. Telling the world you’re open for business as a horizontal tech company reliably attracts early inbound interest from buyers who are already trying to force-fit horizontal tools into domain-specific workflows and are eager for any signal that the vendor intends to support their use case more directly. Nothing was really vertical specific, which is exactly what you'd expect from the ultimate hypergrowth horizontal company dipping their toes into specific industries. But eventually you have to stop changing the sign on the door and start changing the product. Can you guess where the horizontal product was going to run out of road? This is the core dilemma writ large: verticalization requires differentiation, while scale economics of consumer and horizontal push toward unification. I’ve buried the lede so deep here it will be painful to some readers, but what should be shocking to no one is that my perspective is that EHR integration is the only path that meaningfully resolves this tension for ChatGPT for Healthcare. Integration with Microsoft Sharepoint is fine, but it is categorically insufficient for any product that hopes to influence clinical decision-making. SMART Money Well here we are, eight months later! Real vertical investment has begun, which surprised a few people. One friend in the industry messaged me: “Absolutely no way Epic gave ChatGPT API access.” Looking forensically at the announcements, the integration is notably read-only across appointment notes, laboratory results, medications, and specialist documentation. So while I’m not a betting man, I'd wager the house this is a SMART on FHIR launch: That sounds a lot like USCDI! The recommended path for the workflow they outline would be SMART on FHIR Their Health AI lead’s post is evocative of both standalone and EHR launch SMART, which another termed “ChartGPT” and “EHR Plugin” The implementation burden for SMART on FHIR is the lowest of the available integrative paths This is the team who literally did patient-facing SMART on FHIR with Epic last month Most importantly, if you’re a horizontal company, you generally still haven’t taken the full plunge and thus (overly) value reusability. SMART on FHIR is the logical compromise: healthcare-specific enough to matter, but standardized enough to reuse. Nobody Asked Judy Another friend asked “I thought they had to go to each health system, or did they go direct to Epic and now health systems opt in?” Given the trust paradigms in healthcare, this functionally cannot be Epic hoovering up all the data for OpenAI and shoving ChatGPT in their customers’ faces (or they would revolt). However, I do believe the aforementioned terrible coverage by TechCrunch and other outlets is probably responsible for that question, given the 325 million reference. When using FHIR as a business associate to an Epic customer, there is no EHR gatekeeping to speak of, as that isn’t how fhir.epic.com works: You register an app You pick your APIs You test against the sandbox APIs You list as “Ready for Production” Hospitals pick your app You test and go live with them Bluntly, nobody had to say yes or no in Verona (nor were they given the chance). Vendor Services (their next developer tier up that I doubt OpenAI is using quite yet in this initial release) certainly has contractual paperwork that some resent, but even there, the twin pressures of mounting antitrust and information blocking make outright gatekeeping increasingly fraught. My friend’s sentiment is, to me, representative of a broader industry neurosis, perhaps a sort of scar tissue of prior eras: people assume the gate is still there and never actually try the door. There are certainly other ways Epic (and any EHR) can put its thumb on the scale, but they are not so dumb as to stand in front of a federally mandated API and play bouncer at this exact moment in time. So I think they can and probably should go deeper, as this release is at best parity and at worst behind vertical-specific competition. OpenEvidence did a basic SMART launch with Sutter Health in February, allowing for more convenient evidence search by providers. They then add patient-context (the equivalent SMART on FHIR flow to what we see here) when Cedars-Sinai went enterprise-wide in May. UpToDate has four distinct applications across deeper workflows like patient engagement listed in Epic Showroom and announced a partnership with Epic to power Art at UGM Abridge and other ambient scribes have invested deeply into the deepest bidirectional clinical copilot workflow with integrations well beyond SMART on FHIR. In that light, the “Who is OpenAI primarily targeting here?” is clear. This release brings them into striking distance of OpenEvidence, but not the others quite yet. They are the only one of the three you can reach without building something truly Epic-specific. When will they go further? Competition is a great motivator to overcome the horizontal demons and start building things that can’t be reused: not across industries, not across EHRs, maybe not past the customer you built them for. That’s the price of actually verticalizing. The question is if and when OpenAI will be willing to pay it. Month in Review Here is the monthly review. As a reminder, this is a regular round-up of the month’s posts and other content to surface things you may have missed across regulation, litigation, interoperability, and beyond. AI assistance is used in these bullet summaries so I can focus on articles. Articles Published: None this month Video Content: The Information Exchange: Standards-based Thruple Edition (Aug 14): Back to school for us too, with Brad reporting in from the CMS Health Tech Ecosystem’s one year anniversary in DC. We get into the January CMS-0057 deadline, the fall rulemaking reading list, and why enrollment still keeps most apps off FHIR. The Information Exchange: Epic Dúnadan Edition (Aug 25): A UGM roundup with Ryan Brickner joining for the first time to check our takes against what the building actually thinks. Rangers, Ergo sitting on top of EHI, and a down-market lineup that needs some cuts. Regulatory: Stacked Deck, Bad Hand (Aug 05): ONC’s website refresh took the entire HIT Policy Committee record with it, so I rebuilt the archive and went looking for the regulatory capture story everyone assumes is buried in there. Stacking the deck and winning the hand turn out to be very different things. The Sixth Generation of Patient Access (Aug 19): A quick catalog of the five generations of patient access we’ve layered on since HIPAA, and the two candidates now competing to be the sixth. One is planned. The other is the market routing around the plan entirely. Court cases: Three Cases Walk Into a Docket (Aug 06): Two surprise settlements cleared the board in a single week, and then Judge Maddox dropped ninety-four pages on Vyne v. Henry Schein. The sleeper is a DMCA holding that makes direct-to-database a considerably riskier business model. Epic v. Health Gorilla: Into the MDL (Aug 10): Nine class actions are headed to Miami, and the Panel signaled it wants to bring the case that spawned them along too. That would leave Epic arguing the requests were obviously fraudulent in one courtroom and unknowable in the other. Amazon v. Perplexity: Agents Are Legalized! (Aug 11): The Ninth Circuit vacated the injunction against Comet, holding that the user is the one accessing the servers rather than the company that built the agent. A real win for agentic access, and a much narrower one than the headline suggests. Veeva v. Epic: Come At Me, Bro (Aug 26): Epic’s response brief wants the dismissal affirmed and, unusually, wants the opinion published as precedent. Buried in it is Epic’s own description of what its non-competes actually prohibit, which current and former employees should read closely. EHRs: The Contract Epic Would Never Sign Today (Aug 04): A 1999 SEC exhibit catches Epic licensing nearly its entire product line, Tapestry included, to the company that became TriZetto. The marketing services menu attached to it is the part that will make you blink. Forecast from Verona (Aug 07): The Epic Almanac makes one argument six different ways: the AI is only as good as the networks behind it. Emmie headlines, Art’s context stack is the most ambitious part, and Penny finally gets an autonomous coding date on the calendar. Works With Epic MyChart (Aug 17): Epic’s first new Showroom category since the death of Workshop certifies hardware instead of software, badge on the box and all. Made for iPhone, but for blood pressure cuffs, and rough news for anyone selling the RPM stack sitting in between. UGM Hot Takes 2026 (Aug 20): Everyone else covered the AI announcements, so I went after Savvy deleting the payment gateway, Rangers as Boost with the timer removed, and a down-market lineup with too many entries. Plus the Health Grid tidbits I cannot help myself on. MyChart Central Grows Up (Aug 24): Device data and Emmie turn Epic’s identity hub into a full consumer platform, which is both a logical answer to ChatGPT and a bit of a mistake. It also happens to be the best scraping target Epic has ever shipped. Industry Analysis: The Wrong Yardstick (Aug 12): Vertical software keeps getting judged against Superhuman and Notion, which is the wrong bar entirely. Your user is comparing your product to a whiteboard and forty phone calls before lunch. Primitives vs. Abstractions (Aug 27): Developers want building blocks, systems of record prefer to hand out business logic, and both sides have a real case. There’s no test from the outside that separates the engineering reason from the competitive one, which is why this keeps ending up in court. Cross-industry Comparisons: The Two Kinds of Platform Power (Aug 18): Attention power and record power are different problems that keep getting handed the same regulatory toolkit. Congress’s latest swing at Big Tech shows both what’s possible and where it falls apart. The Dogs of (Platform) War (Aug 21): A CourtListener alert turned up a property management fight with healthcare’s exact shape and none of the Cures Act. Shell prospects, ghost accounts, a notetaker bot that came back to haunt someone, and a lawyer arguing both sides of the same theory in two states. Fractals All the Way Down (Aug 31): Yardi dominates property management right up until you zoom into one segment, where AppFolio owns it outright and Yardi doesn’t appear at all. Where you draw the line around a B2B software market is about to decide an awful lot of cases. Other News: If Judy Had the Courage (Aug 13): A short eulogy for the era when software was allowed to look insane: WinAMP, bold colors, and everything the grey chatbot era has taken from us. External Media: Portland Monthly Health Tech Meetup: Erin O’Brien channeled my own feelings - maybe it’s just because it’s August and beautiful, but the monthly edition of the PDX Health community meetup was a ripper. Make sure to reach out if interested to join for the next one. STAT’s Coverage of Epic This Month: Brittany Trang of STAT did a fantastic job of breaking the FTC investigation that’s been lurking, as well as UGM related coverage, so I had to give her her wish of a meme. Fall Conferences: I’m pumped to be kicking off my fall conference season in NYC at Nabla Accelerate next month, which Chrissy provided the link to apply for. Here’s the rest of my schedule in case you want to meet up: Commonwell (Redwood Shores, CA): Oct 13-14 Open@Epic (Madison, WI): Oct 21-22 eHealthExchange (Austin, TX): Oct 27 Sequoia Project (Austin, TX): Oct 28-29 HLTH (Vegas): Nov 15-18 RSNA (Chicago): Nov 29-Dec 3 Posts I Liked: HTI-6 Should Unbundle API Certification: Josh Mandel makes the case that HTI-6 should split (g)(10) into separate authorization and data certifications, so a PACS or a genomics platform can certify only the role it actually performs. Imaging is the urgent example, but the structure solves a much bigger problem. On implementing ePrior Auth with Epic: Scott Rossignol’s field notes from a live ePrior Auth build on Epic, including the two app registrations nobody warns you about and the CPT mapping problem waiting at the end. CMS-0057 implementations are going to be such a beast. Healthcare point solutions are starting to look a lot like streaming services: Spencer Dorn runs the cable-to-streaming arc against health IT and lands squarely on the bundling half of the cycle. Bundling can be good! It can also be bad! Life is nuanced. Health API Guy is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
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