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Atlassian Data Center Flaw Draws Exploitation Attempts Within Two Hours of Public Details
Attackers are exploiting an Atlassian Data Center flaw that enables unauthenticated access to specific webroot files.
NLR Chamber CEO to exit for Florida post
The North Little Rock Chamber of Commerce announced Tuesday (Oct. 6) that President and CEO Derrell Hartwick will depart the organization effective October 9, 2026. Hartwick has served more than...
ICE reviewed tens of millions of voter records looking for noncitizen voters, records show
The Department of Homeland Security’s sweeping election-fraud operation has drawn on tens of millions of records, scrutinized dozens of nonprofit voter-registration groups and considered deploying undercover agents to investigate organizations suspected of helping noncitizens register to vote, according to newly obtained internal documents.
Big Brothers Big Sisters of Broward County and Henderson Behavioral Health Win Community Catalyst Award - Florida Hospital News and Healthcare Report
Ty Richardson, Interim President & CEO of the Greater Fort Lauderdale Chamber of Commerce; Vivian Demille, COO of Henderson Behavioral Health; Shari Thomas, Director of Youth & Family at Henderson […]
Weekly Stat Review: Post Week 4 edition
Offense continues putting on a show while the defense figures out how to overcome significant injuries.
Arctic Wolf CEO: AI Has Changed Cybersecurity Forever
Arctic Wolf CEO Nick Schneider joins the Twin Cities Business Show to talk about how artificial intelligence has fundamentally changed cybersecurity. According to Schneider, we are already past the point where humans can defend against agents, and need agents of their own to keep themselves safe. Schneider explains how AI is giving cybercriminals new capabilities,
India's 2036 Games bid fuels sporting superpower dreams but hurdles, heavyweight rivals remain
India's bid for the 2036 Olympics sits at the heart of a wider effort to transform the country into a sporting superpower and the Indian Olympic Association is convinced it can come out on top in a fiercely competitive process, its chief executive officer Raghuram Iyer told Reuters on Wednesday.
New global guidelines warn against obesity drugs for children under 10
Care should focus on healthy eating and exercise, not medicines such as weight-loss injections, says the World Health Organization
Ohio reading scores rise. Is the science of reading working?
This story was originally published by The 74. Ohio students’ reading scores rose slightly last school year, the first the science of reading was mandated, but it’s too soon to say whether the phonics-based lessons are making a difference. About 63 percent of Ohio third graders — the grade educators have long considered the most […]
WHO endorses lifestyle changes over GLP-1 drugs in child obesity fight
The World Health Organization on Wednesday recommended diet, exercise and counseling over popular weight-loss drugs in its first global guidelines addressing rising obesity among younger children.
North Bend Mayoral Candidates address the business community at recent forum
Candidate forums continued at the Bay Area Chamber of Commerce’s (BACC) Business Connection Luncheons on Wednesday September 30, 2026. This week, the chamber hosted current North Bend Mayor Jessica Engelke,
Tom Cruise digs into uncharted territory in ‘Digger’
Don’t look now, but Tom Cruise’s latest movie, Alejandro G. Iñárritu’s Digger, is not your typical Tom Cruise film. The charming, boyish-looking star of Mission: Impossible fame is shedding his familiar action-superstar image. Wearing a fat suit, cowboy boots and disheveled hair, and at one point carrying a dying cat, Cruise portrays Digger Rockwell, an egocentric, fast-talking octogenarian oil billionaire whose irresponsible drilling…
ANF Investigates: Allegiance Health plans to sell 2 struggling Acadiana hospitals
Allegiance Health Management plans to sell four financially struggling rural hospitals in Louisiana, including two in Acadiana, at the directive of the Louisiana Department of Health. The two Acadiana hospitals involved are Mercy Regional Medical Center in Ville Platte and Acadian Medical Center in Eunice. Both facilities have dealt with a number of problems, including unpaid payroll taxes, broken equipment, overdue bills, the loss of doctors and staff, and a shortage of critical supplies.
ANF Investigates: Allegiance Health plans to sell 2 struggling Acadiana hospitals
Allegiance Health Management plans to sell four financially struggling rural hospitals in Louisiana, including two in Acadiana, at the directive of the Louisiana Department of Health. The two Acadiana hospitals involved are Mercy Regional Medical Center in Ville Platte and Acadian Medical Center in Eunice. Both facilities have dealt with a number of problems, including unpaid payroll taxes, broken equipment, overdue bills, the loss of doctors and staff, and a shortage of critical supplies.
ANF Investigates: Allegiance Health plans to sell 2 struggling Acadiana hospitals
Allegiance Health Management plans to sell four financially struggling rural hospitals in Louisiana, including two in Acadiana, at the directive of the Louisiana Department of Health. The two Acadiana hospitals involved are Mercy Regional Medical Center in Ville Platte and Acadian Medical Center in Eunice. Both facilities have dealt with a number of problems, including unpaid payroll taxes, broken equipment, overdue bills, the loss of doctors and staff, and a shortage of critical supplies.
Diocese introduces Mental Health Ministry, invites all to special Mass
Earlier this month Pope Leo shared his October prayer intention for mental health ministry to be established throughout the Church, helping to overcome the stigma and discrimination of people with mental illnesses. In the Columbus diocese, the Vicariate of Catholic Social Doctrine has worked since January to animate Mental Health Ministry and support families, clergy, […]
Kristaps Porzingis still not around Warriors as he deals with “concerning” health condition
Kristaps Porzingis did not travel with the Warriors to Hawaii for training camp, was not at Tuesday’s preseason game at Chase Center
Plessinger Signs With Triumph For Supercross And Motocross
Photos by Triumph Racing. Aaron Plessinger is heading to Triumph, inking a two-year agreement to campaign the TF 450-X for 5.11 Triumph Factory Racing in AMA Supercross and Pro Motocross. He takes on an important role in Triumph's 450 development program for the 2027 SuperMotocross World Championship. [cuttext][/cuttext] The move ends Plessinger's five-season run with Red Bull KTM Factory Racing. For Triumph, the signing adds a proven race-winner to a program still establishing itself at the spo
Islamic Development Bank and Global Fund Strengthen Partnership to Advance Sustainable Health Financing
GENEVA/JEDDAH – The Islamic Development Bank (IsDB) and the Global Fund to Fight AIDS, Tuberculosis and Malaria (the Global Fund) signed on 6 October a new Partnership Agreement to strengthen collaboration and accelerate investments in health across low- and middle-income countries. The agreement, which marks a new chapter in a long-standing relationship, establishes a framework for aligning investments and coordinating financing, mobilizing additional resources, and supporting country-led efforts to build…
Seahawks’ win over Chargers in Week 4 spawned rare occurrence
The Seahawks’ Week 4 matchup against the Chargers was the first time that interceptions were thrown on the first two plays of a game in decades.
Sinclair Community College opens new Fire Science Academy
DAYTON, Ohio (WDTN) – Sinclair Community College is celebrating the grand opening of its new Fire Science Academy. The new Fire Science Academy training facility, which is located on Commerce Park …
What did people who went to Trump’s Nebraska rally have to say?
While the perception of Republicans seems gloomy ahead of the midterms, thousands came to see and support President Donald Trump at his rally.
Three Years of 80% Charge Limits on iPhone: The Results
Since 2023, Apple's newer iPhones have had an 80 percent charge limit for those who want to extend battery lifespan. Charging to 80 percent instead of 100 percent is supposed to put less stress on the battery, improving longevity. For the last three years, I've used that setting on my iPhone. I started with the iPhone 15 Pro Max, then did the iPhone 16 Pro Max, and most recently, the iPhone 17 Pro Max.
Option Care Health (OPCH) Rockets as CD&R, McKesson Table 37% Premium Bid
Option Care Health Inc. (NASDAQ:OPCH) soared by as much as 33 percent on Tuesday to $31.11 apiece following news that it is merging with Clayson, Dubilier, & Rice LLC (CD&R) and McKesson Corp. for $5.8 billion. In a joint statement, the firms said that they entered into a definitive agreement under which they will acquire […]
Ohio State Given Almost 100 Percent Chance to Defeat Maryland
The Ohio State Buckeyes have been given an almost perfect chance to win this weekend.
NFL Drops Hammer With Punishment Over Denver Broncos Game
The NFL has stepped in with costly discipline over an in-game altercation involving Denver Broncos head coach Sean Payton. The post NFL Drops Hammer With Punishment Over Denver Broncos Game appeared first on HEAVY.
Dr. Brett Bruininks New Department Chair of Health and Exercise Science - Newsroom
Brett Bruininks has been named chair of the Health and Exercise Science Department at the University of St. Thomas.
Dr. Brett Bruininks New Department Chair of Health and Exercise Science - Newsroom
Brett Bruininks has been named chair of the Health and Exercise Science Department at the University of St. Thomas.
EU launches network to harness health data and AI for cardiovascular care
A new EU-funded flagship initiative to harness the power of health data and artificial intelligence (AI) across the continuum of cardiovascular care has been launched, with funding from the EU4Health Program.
Ronald Waterreus Defends Matej Kovar Amid 'Unfair' PSV Criticism
Former PSV player Waterreus tackles the harsh scrutiny surrounding the Czech keeper, highlighting a crucial Harry Kane save while questioning if tactical demands lead to his perceived errors.
‘Business for Democracy’ Sees Friends Rising and Keep Showing Up Rally in Downtown Plaza
On a scorching 100-degree Saturday midday on October 3, 2026, local volunteers from Culver City and Friends Rising, joined by Keep Showing Up Culver City, led a march and rally. The demonstration f…
Laredo Chamber sets January date for VISION 2027 business event
The Laredo Chamber of Commerce has set the date for VISION 2027: State of the Business Community.
ConnectOne Bank joins program for lower-rate business loans in NY
ConnectOne Bank is participating in New York's Linked Deposit Program, which provides small and middle-market businesses access to lower-interest commercial loans. This initiative supports business expansion and innovation by reducing borrowing costs and improving cash flow for eligible companies across Long Island and New York State.
What Nathan Gallagher said in final 'Below Deck' episode before arrest
"Below Deck Mediterranean" cast member Nathan Gallagher talked about his young family's future and overcoming challenges in his final episode before he was arrested and convicted on domestic violence-
DeKalb hosts small business summit Oct. 14
Join the DeKalb County Chamber of Commerce Small Business Summit on Oct. 14 at the Emory Conference Center for expert panels.
Fayetteville mixed-use neighborhood Drake Farms announces first business
The new mixed-use neighborhood under construction in North Fayetteville, Drake Farms, has announced its first commercial tenant.
Students Use Forensic Science Skills in Escape Room
Hundreds of students from across the region put their problem-solving skills to the test this week during the Regional Science Consortium’s annual Forensic Science Escape Room. Elementary school students had just a few hours to figure out how someone died as part of a forensic science escape room activity. The Regional Science Consortium partnered with Mercyhurst University for the 10th year of the event, which is taking place at the Tom Ridge Environmental Center. It began Monday and runs through Thursday.Throughout the week, more than 250 students are working to solve murder mysteries using real forensic science techniques. Students must analyze the evidence, piece together clues and solve the crime before time runs out.Organizers said the event gives students interested in pursuing forensic science in college a firsthand look at what a career in the field could entail.Sarah Skelton, Special Gifts Coordinator at Iroquois, said the activity provides students with an opportunity to develop skills that can sometimes be difficult to practice in a traditional classroom. "It really helps them to work in teams and on critical thinking skills. Which, not that they don't get these opportunities, but it's hard sometimes in the classroom to develop those higher-level thinking skills”, said Skelton.Students also get a chance to learn how forensic science is used in real-life investigations. As Skelton explained, "What are the real-life applications? What would you actually see in a crime scene? How would you handle these types of forensic investigations? So it's really cool our kids get to see what opportunities are out there and possibly a career field one day."The popular event has grown over the years, with some students returning year after year. Organizers said watching those students grow and develop their interests is one of the highlights of the program.Jeanette Schnars, the Executive Director of the Regional Science Consortium said it's rewarding to see how students' interests evolve as they get older. According to Schnars, "How they have grown and matured and where their interests are going and maybe they aren't going into forensics, but if they are going into sciences or different disciplines, so it's really fulfilling to see how they have matured."One student who continues to enjoy the event is sixth-grader Mia Harvey of Iroquois. Harvey hopes to pursue a career in medicine and says the forensic science activities are helping her explore her interests, "One day I want to become a neurologist, and learning about the bones is probably going to help me."Harvey said her favorite part of the event is the real-life application of what she's learning. "While you are trying to find the clues, they teach real stuff that you would need to know”, said Harvey.Event organizers said if students are learning while having fun, then the program is accomplishing its goal. "Not only are they learning the science, but they are having fun with it too”, said Schnars.Adults will also have a chance to take part in the experience this Saturday during an adult version of the escape room, which will feature food, drinks and entertainment. For more information, click here.The Forensic Science Escape Room has become one of the Regional Science Consortium’s most popular events, with teachers signing up their students as soon as registration opens in August.
Charm Security Appoints Dr. Elizabeth Huppert as Behavioral Science Director
Former JPMorgan Chase Vice President and Behavioral Scientist joins to advance behavioral science in agentic AI for fraud, scams, and cybercrime.NEW YORK, NY / ACCESS Newswire / October 6, 2026 / Security today announced the appointment of Dr.
Brazil: Lessons from a Disaster
By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.
Federal Employees Face 10.9% Increase in Health Premiums as Open Season Dates Announced
Federal employees will pay higher prices for health insurance in 2027. On average, federal employees enrolled in the Federal Employees Health Benefits Program (FEHB) will pay 10.9 percent more toward their premiums in 2027, marking the third straight year of double-digit increases in the employe
Bluevine and Coverdash Partner to Embed Business Insurance for Small Businesses - ProgramBusiness
Bluevine and Coverdash have partnered to bring commercial insurance directly into Bluevine’s small business banking platform.
As U.S. Cybercrime Losses Top $20 Billion, Bank of America Expands Fraud Education for Small Business Owners
New Educational Tools, Fraud-Prevention Resources and Webinars Aim to Help Entrepreneurs Protect Their Businesses From Increasingly Sophisticated Scams Key...
Northwestern Linebacker Named Big Ten Defensive Player of the Week
Northwestern captain Braydon Brus earned Big Ten Defensive Player of the Week honors after recording nine tackles, a sack and his first career interception in the Wildcats’ 34-13 win over Penn State.
Hidden Risks and Costs of Maternal/Infant Health that Health Plans Miss
A new report from ProgenyHealth offers a window into how the business works with commercial and Medicaid plans to close gaps in maternity and NICU care management that traditional programs overlook.
American Journal Of Public Health Study Examines Political Differences In Perceptions Of Vaccine Safety And Effectiveness
Vaccine perceptions can influence acceptance and uptake. Dr. Dror Walter, with the Department of Communication at Georgia State University in Atlanta, and colleagues examined these perceptions using data from a national probability sample of 1,763 US adults surveyed in November 2024.
How do Rockford-area businesses feel about the economy? Here’s what surveys say
By Kevin Haas Rock River Current Get our free e-newsletter ROCKFORD — Businesses in the greater Rockford region say their companies are in good health, despite waning confidence in the local economy. That's according to the latest results of the Greater Rockford Chamber of Commerce's quarterly business sentiment survey, which drew responses from 125 companies
Masterclass Launches Podcast With Martha Stewart as First Guest
Masterclass has launched its first-ever podcast "Other People's Business," with Martha Stewart and Jeffrey Pfeffer set as first guests.
Bluevine adds Coverdash business insurance to banking platform
Jersey City-based Bluevine has added Coverdash-powered commercial insurance options to its digital banking platform for small businesses.
DITP Promotes Thailand's Entertainment Industry on the Global Stage with "Thai Night Busan 2026& ...
BUSAN, SOUTH KOREA - Media OutReach Newswire - 6 October 2026 - The Department of International Trade Promotion (DITP), Ministry of Commerce, has announced its readiness to bring Thai companies in the film and content industry to the Asian Contents & Film Market (ACFM) 2026, a major marketplace
Short bursts of exercise may improve fitness and blood sugar in sedentary adults
A systematic review and meta-analysis of 22 studies involving 994 sedentary or inactive adults found that brief “exercise snacks” were associated with improvements in VO₂peak, blood glucose, and triglycerides.
Trump says he will stop using taxpayer funds for self-promoting ads after backlash
President claims commercials were ‘positive promotion for our Great USA’ but says he will now cover their cost
Ndour on Juventus radar after firing Azzurrini to Euros
Juventus are among several clubs keeping tabs on Cher Ndour after the Fiorentina midfielder fired Italy’s Under-21s to the European Championship.According to Tuttomercatoweb, the Bianconeri see the ...
Workforce training program earns another No.1 ranking for Virginia
Virginia’s workforce training program has earned another No. 1 national ranking as the commonwealth competes for companies looking for workers trained for specialized jobs.Area Development, a major national trade publication, ranked Virginia first for workforce training programs in its 2026 Top States for Doing Business report. The recognition highlights the Virginia Talent Accelerator Program, which provides customized recruitment and training at no cost to qualifying companies opening or expanding operations in the commonwealth. a
Kamala Harris has a 2028 opening
The former Democratic standard bearer retains considerable respect in the party, but there’s an undercurrent of anxiety about her return to the political conversation.
Gas stoves put restaurant cooks’ health at risk, new study finds
Dangerous amounts of heat and air pollution swirl in most commercial kitchens — even when the stoves are off. Switching to electric appliances helps…
Global Heat Forum seeks to galvanize action and investment
BANGKOK – The first Global Heat Forum opened today to unlock finance and supercharge solutions on extreme heat, amid record-breaking temperatures and an intensifying El Niño. The four-day event in Bangkok takes place as the Thai capital recovers from devastating rainfall and deadly floods.
Deshaun Watson's Rollercoaster Performances for the Cleveland Browns
I'm going to focus on EPA for this piece. EPA stands for Expected Points Added, which measures the value of individual plays based on how much they increase or decrease a team's likelihood of scoring.Here is a fantastic video explaining what EPA is and why it is a measure that looks at years on NFL history rather than one person's subjective opinion on a certain play.Deshaun Watson's Current...
Critical Atlassian Flaw Lets Unauthenticated Attackers Read Known Files Across 8 Products
Atlassian fixes a critical path traversal in 8 Data Center products that lets unauthenticated attackers read files if exact paths are known.
As federal grant cuts hit social sciences, McInnis ‘worried’ about funds
Yale’s federal funding declined by 1.5 percent in the last fiscal year, with cuts affecting social science fields — which the Trump administration has targeted. Yale President Maurie McInnis said last month that the government had been slow to disburse awards.
Vasseur Admits Ferrari’s Mistake and Praised His Drivers
The Italian team chose slicks at the start, a wrong decision that cost them positions. Hamilton and Leclerc knew how to come back with great tire management to finish third and fourth.
ClickFix Smuggles Payloads Through Browser Cache to Bypass Windows Run Limits
Microsoft observed ClickFix attacks using browser cache smuggling to execute cached VBScript and launch a credential-targeting malware chain.
“The Designs Are Way Cuter”: The Big Business of Bootleg Merch
It’s been a busy season for bootleggers in New York, with the Knicks’s championship and the World Cup leading right into Harry Styles’s MSG residency. How did this gray market get so big?
Pistons Newcomer Sets Tone Early After Altercation With Suns Enforcer
A Pistons newcomer set the tone early after a heated altercation with Dillon Brooks led to a lengthy review and two penalties. The post Pistons Newcomer Sets Tone Early After Altercation With Suns Enforcer appeared first on HEAVY.
Selma Blair breaks silence on fallout after Islamophobic comment apology
More than two years after Selma Blair posted a comment widely criticized as Islamophobic, for which she later apologized, the actress has revealed the alleged repercussions she experienced in her
Swedish regulator temporarily revokes Charm Entertainment’s casino license
The Swedish Gambling Authority (Spelinspektionen) has issued a temporary revocation of Charm Entertainment AB’s license to operate commercial land-based casino
Selma Blair breaks silence on being 'erased' after Islamophobic comment
More than two years after Selma Blair posted a comment widely criticized as Islamophobic, for which she later apologized, the actress has revealed the alleged repercussions she experienced in her
Kingman Launches New Effort to Clean Up Business Signs
Kingman launches a community effort to improve sign compliance in commercial areas, enhancing business districts and safety. Kingman Launches New Effort to Clean Up Business Signs
Cincinnati nuisance business rules for late-night bars face fierce opposition
A proposed crackdown on Cincinnati’s so-called nuisance businesses has put City Hall at odds with some late-night bar and nightclub owners.
UK author and politician Jeffrey Archer dies aged 86
Jeffrey Archer, the best-selling British novelist and former politician who was jailed for lying in a high-profile libel case, has died aged 86, his publisher HarperCollins said on Monday.
Executive MBA Grad Garners Industry Honors
The Daily Journal of Commerce has recognized Caitlin Powell, MBA '24, as one of its Women of Vision for 2026.
We issued a Water Advisory for Thea Foss Waterway - Tacoma-Pierce County Health Department
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Trump’s midterm messaging undercuts GOP candidates
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Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
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Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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