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Big Pharma trade group joins legal fight against Illinois drug discount law
PhRMA's lawsuit is the latest challenge to state-based laws designed to protect hospitals, clinics and pharmacies from unfettered access to 340B discounts.
Newsom Promotes Affordable Insulin, But California's Generic Label Off To A Slow Start
By Angela Hart and KFF Health News HealthDay ReportersTUESDAY, Aug. 18, 2026 (HealthDay News) — At a Walgreens in San Francisco’s bustling Japantown neighborhood, pharmacist Margaret On stocks two boxes of long-acting insulin pens from California’s new prescription drug label, CalRx, emblazoned ...
Doctors Worry Grant Changes Will Derail Biomedical Science
Proposed OMB grant review changes could shift science funding from peer-reviewed to subject to political whims, impacting drug development and patient care.
Kratom poison center cases have surged 6,500% in the U.S.
Kratom use and serious health problems linked to it have risen dramatically across the United States over the past decade. Poison center reports jumped from just 19 cases in 2010 to more than 1,200 in 2023, while severe outcomes—including life-threatening complications, disability, and death—also climbed sharply. Researchers warn that kratom can trigger seizures, abnormal heart rhythms, liver damage, and breathing problems, with risks potentially increasing when it is combined with other drugs.
Justice Department watchdog to review DEA tactic that permitted deadly fentanyl to hit streets
The review will examine government policies and wiretap investigations in which the U.S. Drug Enforcement Administration may have learned of fentanyl deliveries before they happened but stood down to avoid jeopardizing larger prosecutions.
Hayden Panettiere’s Health Struggles in Her Own Words, From Depression to Drug Use
From alcohol and drug use to postpartum depression, Panettiere spoke openly about her health challenges in an effort to encourage others to seek help.
The national focus on politicians' health is making its way into the Oklahoma GOP race for governor
Mike Mazzei’s performance in recent debates have created a conundrum for him and our state’s pool of undecided Republican voters who are still trying to suss out their best nominee for governor.
The national focus on politicians' health is making its way into the Oklahoma GOP race for governor
Mike Mazzei’s performance in recent debates have created a conundrum for him and our state’s pool of undecided Republican voters who are still trying to suss out their best nominee for governor.
RFK Jr.’s dangerous love affair with peptides
The health secretary takes a 19th-century approach to U.S. drug safety standards.
Could a drug designed for weight loss help athletes perform better?
GLP-1 weight-loss drugs can reduce weight and improve health, but could they also boost athletic performance?
Cialis is an erectile dysfunction drug. Could it also help you live longer?
In some wellness circles, tadalafil is promoted as a longevity drug. There is evidence showing a link between it and a lower risk of death in men, but there are no well-controlled trials in humans.
Health records in GOP race for Oklahoma governor could help sway voters, experts say
Gentner Drummond’s push to pressure his opponent into taking a drug test taps into voter concerns over candidates’ health and could tip the outcome of the contentious runoff election for Oklahoma’s Republican nominee for governor, some political observers said.
What is Medetomidine? The latest threat in the street drug supply
Medetomidine is a veterinary tranquilizer increasingly found in the illicit drug supply, where it is often mixed with fentanyl and can cause dangerous sedation and withdrawal.
GLP-1 weight loss drugs may boost results but raise oral health risks, dentist warns
This 10-cent heart drug cuts hospitalizations by 25%
A centuries-old heart drug costing less than ten cents a day could help keep heart-failure patients out of the hospital. New research suggests low-dose digoxin can reduce heart-failure hospitalizations by about 25%, potentially paving the way for its return as a major treatment.
Science & Medicine: San Antonio's fungus lab is on the front line of a growing drug-resistance crisis
When doctors can't identify a fungal infection, they often turn to UT Health San Antonio's Fungus Testing Laboratory, which has discovered more than 60 new species since 2013. The lab is now racing to fight drug-resistant fungi while helping bring new antifungal treatments to market.
Bernalillo County's Behavioral Health Unit rapidly grows, diverting 911 calls
Officials say the three-unit teams have become more effective since paramedics were authorized to administer the antipsychotic drug olanzapine.
Super Mario 64 is now playable on YouTube
Super Mario 64 is now playable in-browser thanks to a YouTube video that combines the site’s 360°-view spherical video player with closed captions.
Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways
Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.
Earth, Wind & Fire drummer John Paris placed into 'induced coma'
Singer Shelly Clark White, wife of Earth, Wind & Fire bassist Verdine White, has an update on the band's drummer John Paris after he was hospitalized ahead of a recent
Trump takes credit for prescription drug prices falling in July
The Bureau of Labor Statistics reported this week that medicinal drug prices fell 3.1% in July — the steepest decline in over 60 years
Spanberger touts progress keeping insulin, prescriptions affordable during tour of Northern Va. health clinic
Virginia Gov. Abigail Spanberger is touting the progress the state has made in capping insulin costs and keeping prescription drugs affordable.
AHA responds to FDA RFI on health and safety benefits regarding non-device software
The AHA Aug. 13 responded to a Food and Drug Administration request for input on the risks and benefits to health and safety associated with non-device software.
The drug lenacapavir is a mighty weapon against HIV. Its rollout gets mixed reviews
It's a twice-a-year injection that is remarkably effective in preventing an HIV infection. Distribution is starting. But questions are being raised about getting it to the areas that need it most.
Mock Crash Kicks off Drive Sober or Get Pulled Over Campaign on Health Science Campus
UToledo Health joined local law enforcement and health agencies to stage a realistic drunk driving crash simulation outside the Lloyd A. Jacobs Interprofessional Immersive Simulation Center.
Xdinary Heroes' Gunil leaves band and JYP Entertainment after fan insult allegations
The drummer is terminating his contract with JYP Entertainment over the controversy, with the band set to continue as a quintet.
Seven Virginia Tech faculty elected to 2026 Virginia Academy of Science, Engineering, and Medicine
The new members represent the university's research breadth in wireless communications, cybersecurity, cancer biology, medical education, AI, drug delivery, and comparative oncology.
INOVIO Reports Second Quarter 2026 Financial Results and Recent Business Highlights
U.S. Food and Drug Administration (FDA) review of Biologics License Application (BLA) for INO-3107 as a treatment for Recurrent Respiratory Papillomatosis...
Cerebras Systems Fast Inference Cloud Business Nearly Quadruples in Second Quarter 2026
GAAP cloud revenue grew 281%, core cloud revenue grew 287% from a year ago600 MW of data center capacity now under contractManufacturing capacity to scale more than 10x in 2026OpenAI launch partner for frontier model GPT-5.6 SolPartnerships with AMD and AWS establish Cerebras as the leader in disaggregated inference SUNNYVALE, Calif., Aug. 12, 2026 (GLOBE NEWSWIRE) -- Cerebras Systems (NASDAQ: CBRS), maker of the world’s fastest AI infrastructure, today announced financial results for the second
Popular blood pressure drug recalled
Novartis recalled a single lot of valsartan, a blood pressure/heart failure drug the company sells under the brand name Diovan. According to the FDA, this is a Class II recall.
Hendersonville hospital celebrates opening of Adolescent Behavioral Health Center
WLOS News 13 provides local news, weather forecasts, traffic updates, notices of events and items of interest in the community, sports and entertainment programming for Asheville, NC and nearby towns and communities in Western North Carolina and the Upstate of South Carolina, including the counties of Buncombe, Henderson, Rutherford, Haywood, Polk, Transylvania, McDowell, Mitchell, Madison, Yancey, Jackson, Swain, Macon, Graham, Spartanburg, Greenville, Anderson, Union, Pickens, Oconee, Laurens, Greenwood, Abbeville and also Biltmore Forest, Woodfin, Leicester, Black Mountain, Montreat, Arden, Weaverville, Hendersonville, Etowah, Flat Rock, Mills River, Waynesville, Maggie Valley, Canton, Clyde, Franklin, Cullowhee, Sylva, Cherokee, Marion, Old Fort, Forest City, Lake Lure, Bat Cave, Spindale, Spruce Pine, Bakersville, Burnsville, Tryon, Columbus, Marshall, Mars Hill, Brevard, Bryson City, Cashiers, Greer, Landrum, Clemson, Gaffney, and Easley.
Ozempic may have revealed the brain’s hidden “craving center”
Ozempic-like drugs appear to weaken more than hunger—they may also reduce cravings for alcohol and other addictive substances. Scientists are increasingly tracing this effect to the lateral septum, a brain region that helps connect memories and surroundings with rewarding experiences. Packed with GLP-1 receptors, it may act as a crucial control point between thinking about a reward and feeling compelled to pursue it. The discovery could open new approaches to treating addiction as well as obesity.
‘A mouse can’t tell us what works’: UK scientists to grow miniature human organs for drug testing
Organoids and tissues grown from human cells promise more accurate results, with £20m Cambridge project to create standardised models
Tony Romo’s CBS future remains uncertain as network says it’s still ‘assessing’ his fate
Romo has been placed on indefinite leave after a drunk driving arrest.
As Candida auris spreads, UT Health San Antonio scientist highlights growing threat of antifungal resistance
Life-threatening fungus now in 27 states; Texas with second-most clinical cases Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, Aug. 11, 2026 – As cases of the potentially deadly drug-resistant fungal infection Candida auris have spread to 27 states, including Texas with the second-highest number, a scientist at UT Health […]
Cleveland Cavaliers seek members for dance, drumming teams
The Cavs are holding auditions for three on-court entertainment groups for home games at Rocket Arena.
ZZ Top drummer Frank Beard reportedly exits tour after health issues
ZZ Top drummer Frank Beard is reportedly stepping away from the band's current tour due to health concerns.
Super Mario Bros Speedrunners Are 0.1 Seconds From Perfection
Just six frames stand between these savants and the perfect Mario run
Campbell unites pharmaceutical science, clinical research in future-focused degree
The reimagined bachelor’s program prepares students for careers across the entire drug development lifecycle, with an emphasis on hands-on experience… More on this post
Hollywood Bowl Show Canceled Due to ’80s Rock Legend’s Serious Health Issue
The drummer was forced to sit out a tour last year for the same reason.
Cardinal Health forecasts full-year profit above estimates on specialty drug strength
U.S. drug distributor Cardinal Health on Tuesday forecast fiscal 2027 profit well above Wall Street expectations after topping fourth-quarter profit estimates, driven by sustained demand for specialty drugs.
ZZ Top Drummer Frank Beard Was Behind Show Cancellation
Billy Gibbons and Elwood Francis will continue The Big One tour with a fill-in for drummer Frank Beard.
After 41 Years, Super Mario Bros. Players Are Close to Achieving a Perfect Playthrough
Speedrunners have nearly pulled off the impossible
Q&A: Could better gut health help fight breast cancer?
UVA researchers discovered how an unhealthy gut may help breast cancer spread – and how an existing drug could potentially stop it.
Trump officials propose new requirements for food additives and ingredients
U.S. health officials want food manufacturers to provide more information about new additives and ingredients. Under a proposal announced Monday, food companies would have to notify the Food and Drug
Funding Science for the Long Term: The Role of Private Philanthropy
A drug that reaches a pharmacy shelf today often rests on discoveries made decades earlier. Yet the institutions financing scientific research do not
US health agency moves to increase oversight of food additives
The U.S. Food and Drug Administration on Monday took steps to increase oversight of food additives as part of the Trump administration's "Make America Healthy Again" initiative.
Chrissy Metz Talks '& Juliet' and New Music, Shares Health Update
Chrissy Metz, “This is Us” and “The Hunting Wives” star, joins TODAY to open up for the first time about her decision to use GLP-1 medication and announce her new partnership with health care company Ro. Metz details why she was originally skeptical around weight loss drugs, shares how the medication has improved her life, dishes on performing in “& Juliet” and teases new music in the works.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
Chrissy Metz Reveals She’s Taking a GLP-1 Drug: EXCLUSIVE
The actor discussed the mental and physical changes she’s noticed since partnering with Ro.
Kylo Peptides Expands Research Catalog to 36 Compounds as Peptide Science Enters a Record Growth Cycle
US research-peptide supplier scales its catalog against a market that analysts value between $47 billion and $141 billion, as peptides hold near 10% of new FDA drug approvals and GLP-1 use among American adults doubles in 18 months.Sheridan, Wyoming, Aug. 10, 2026 (GLOBE NEWSWIRE) -- Kylo Peptides, a US supplier of research-grade peptides, has expanded its catalog to around 36 peptides and research blends, the company announced today. The milestone lands during the most active growth period in t
Morning Mail: inside the political ‘meme factories’; China questions detainee’s death; Netanyahu rejects Trump’s Gaza plan
‘Buzzer’ economy drumming up outrage online; China’s ‘grave concern’ over death in detention; Trump’s Gaza peace plan in doubt
The Lancet Regional Health – Europe: Europe’s failure to deliver on drug-resistant TB
The Europe's TB paradox: some of the world's wealthiest and most advanced health systems are failing to implement known tools to tackle drug-resistant TB.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Public health alert issued for meat and poultry products containing recalled jalapeños
The U.S. Department of Agriculture’s Food Safety and Inspection Service is issuing a public health alert for meat and poultry products containing Food and Drug Administration-regulated jalapeños that may be contaminated with Salmonella.
Thunder Entertainment announces auditions for drummers and Storm Chasers in OKC
Thunder Entertainment is giving fans the chance to join Oklahoma City’s "Loud City" atmosphere by hosting auditions for the Thunder Drummers and Storm Chasers later this month.
What are Zyn nicotine pouches and are they safe?
The Food and Drug Administration is allowing the company Zyn to advertise some of its nicotine pouches as safer in some ways than smoking cigarettes.
Overcrowding, drugs and health crisis behind Mecklenburg jail deaths, sheriff says
Recent deaths spark state investigations as leaders remain split on reopening Jail North
On Sugar Ray, Pavement and \'90s music nostalgia in 2026 [Unscripted]
Nostalgia, and our relationship with it, is a funny thing. It’s a potent drug that makes the hazy feel distinct and something clear seem warped. I recently saw two bands
Drug-resistant fungas on the radar in Michigan as health experts monitor spread
The fungus can live on surfaces, move from person to person and, in some cases, resist the drugs used to treat it. For people who are already sick, the fungus can become life-threatening and, in some cases, fatal.
Vitamin C may fight cancer — but not the way scientists once thought
Linus Pauling was widely mocked for claiming that vitamin C could fight cancer, especially after trials using vitamin C pills showed no benefit. Researchers now know that intravenous vitamin C reaches vastly higher concentrations and can behave more like an experimental cancer drug than an ordinary supplement. Early studies suggest it may damage vulnerable cancer cells, reduce treatment side effects, and possibly improve outcomes for some patients.
Everyone's talking about hormone therapy for menopause. Should I be on it?
For years doctors advised women against hormone therapy for women in the menopausal transition. Now everyone's talking about how great it is. Is it really a wonder drug that women should all be on?
Giants news: Dru Phillips’ injury, training camp updates
New York Giants headlines for Friday.
New Orleans Saints Rookie Wide Receiver and Son of WWE Star Suspended 6 Games
New Orleans Saints rookie wide receiver Brock Rechsteiner catches a six game suspension from the NFL league office. While the current reason for the suspension in unknown, suspensions for performance enhancing drugs start at four games. They increase to six games when there is an attempted manipulation. Brock Rechsteiner has been suspended by the Commissioner […] The post New Orleans Saints Rookie Wide Receiver and Son of WWE Star Suspended 6 Games appeared first on HEAVY.
Wearable ultrasound patch boosts REM sleep without drugs or surgery
A new wearable patch may help people reach REM sleep faster and remain there longer without medication or surgery. In a study of 28 participants, the device shortened the time to REM by 43 minutes and extended it by about 16 minutes. Researchers also observed signs of improved stress regulation and changes in brain circuits tied to emotion.
Cornerback Dru Phillips has ‘mild’ knee sprain
Cornerback Dru Phillips has “mild” knee sprain.
Talented Giants’ 14-Game Starter Suffers Injury Setback
New York Giants head coach John Harbaugh said an injury to 14-game starter Dru Phillips could result in signing another cornerback. The post Talented Giants’ 14-Game Starter Suffers Injury Setback appeared first on HEAVY.
New heart drug targeting inflammation falls short in clinical trial
The ZEUS trial fell short, but Novo Nordisk still has high hopes for HERMES and ARTEMIS.
Xeris raises outlook despite posting $31.1 million loss
Executives argue the loss reflects a one-time accounting charge to clear outstanding debt rather than the drugmaker's performance.
A Promising Heart Drug Fails, Challenging a Long-Held Theory of Disease
The drug targeted inflammation, and its shocking failure has experts questioning whether inflammation really does cause heart disease.
Drunk driver crashes into business
According to WFFD Assistant Fire Marshal Eddie Mawson, the driver was drunk.
Merck KGaA raises profit guidance on momentum in Life Science, Electronics units
Germany's Merck KGaA lifted its earnings guidance range for 2026 on Thursday, citing a further gain in demand for its drug manufacturing supplies and semiconductor materials, while posting better-than-expected quarterly results.
FDA approves first mRNA-based flu vaccine
The US Food and Drug Administration on Wednesday approved the United States’ first mRNA-based flu vaccine for adults 50 and older, drugmaker Moderna said.
Wisconsin pharmacist says Trump’s tariffs could end his business
The owner of Fitchburg Family Pharmacy says his pharmacy could close due to Trump’s tariffs on generic drugs.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Why AI Still Hasn't Had Its Einstein Moment
AI is having a remarkable run in science. It’s helping researchers predict protein structures, improve weather forecasts, discover new materials, and speed up drug discovery. Researchers are getting results far […]
NSF Presents Highest Award to H-SC Professor
The National Science Foundation (NSF) has awarded its most prestigious grant to Elliott Professor of Chemistry Timothy M. Reichart for his work in drug discovery, chemical protein synthesis, and educational methods that advance the sciences.
AI finds previously undetected health risks during sleep studies
We also report on another promising experimental non-opioid pain drug for use following surgery.
The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
Maryland’s youth turning over a new leaf? Survey shows positive trends.
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Google Is Teasing Some Kind of Notification Light on the Pixel 11’s Camera Bar
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UT San Antonio scientist highlights growing threat of antifungal resistance
For decades, scientists have studied antibiotic resistance, which is how bacteria evolve mechanisms to evade lifesaving drugs. Now, researchers are warning that a similar challenge is emerging among fungi, where resistance to frontline antifungal medications is making serious infections increasingly difficult to treat. Nathan Wiederhold, PharmD, director of the Fungus Testing Laboratory and professor […]
IDEAYA Biosciences Reports Second Quarter 2026 Financial Results and Provides Business Update
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Cuyahoga County Sheriff’s Department Narcotics Unit puts drug organization out of business
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Tommy Sullivan and John Ziegler to Perform at LI Music & Entertainment Hall of Fame on Aug 16th
As part of the Long Island Music and Entertainment Hall of Fame Soundtrack to Summer Series, Musician Tommy Sullivan (a member of the Brooklyn Bridge) will perform LIVE music and Comedian John Ziegler will open with comedy set at the Long Island Music and Entertainment Hall of Fame in Stony Brook Village (97 Main Street, Stony Brook, NY) on Aug. 16th from 3-4pm. The event is free for members or with general admission ticket purchase or $10 at the door concert ticket purchase. For details on this and upcoming events please visit https://www.limusichalloffame.... About Tommy Sullivan A life-long Long Islander and proud U.S. Army veteran, Tommy Sullivan enlisted in 1965 and was accepted to the United States Military Academy Band, where he created the first official rock group at West Point. Reentering civilian life in 1968, he helped create the Rhythm Method, a 7-piece Long Island band which was discovered by Johnny Maestro, then singing lead with the Del-Satins. The combined groups became the Brooklyn Bridge. As band leader and musical director, Tommy penned the group’s horn arrangements on every Bridge hit, including their gold record, Worst that could happen. Upon leaving the Bridge, Tommy co-founded Atlantic Records’ supergroup Ramatam, which was Jimi Hendrix Experience drummer Mitch Mitchell’s first group following Hendrix’ death. For the second Ramatam LP Tommy wrote and orchestrated original material which featured select members of the NY Philharmonic Orchestra. Together with Johnny Maestro, Tommy co-produced Johnny’s final CD, Peace on earth. The critically acclaimed album features Tommy’s arrangements & orchestrations, plus several of his original songs. A Charter Inductee to the LI Music Hall of Fame, Tommy Sullivan continues to write, record, arrange and produce records, serve as musical director/ arranger/conductor for projects across many musical genres plus donates dozens of performances annually for numerous charity events. Tommy Sullivan’s dynamic and unique one-man show, A thousand memories, featuring his vocals and performances on four instruments, has been packing concert auditoriums, nightclubs, private parties–even vineyards-for the past several years. John Zeigler Born and raised in New York, John has performed stand-up comedy for close to 20 years and was the winner of the 2016 "Funniest Comic on the East Coast" Contest at Mohegan Sun. John's opened for such comics as Sebastian Maniscalco, Gilbert Gottfried, Jim Breuer and Robert Klein. He currently headlines clubs across the country and regularly tours with legendary comedian Bobby Collins. John recently released his Dry Bar Comedy Special and Getting My Affairs in Order.
UT San Antonio scientist highlights growing threat of antifungal resistance
For decades, scientists have studied antibiotic resistance, which is how bacteria evolve mechanisms to evade lifesaving drugs. Now, researchers are warning that a similar challenge is emerging among fungi, where resistance to frontline antifungal medications is making serious infections increasingly difficult to treat. Nathan Wiederhold, PharmD, director of the Fungus Testing Laboratory and professor […]
Concert to benefit Everybody Eats
Flash in the Pans, a renowned Blue Hill community steel drum band, will hold a donation-based concert in Knowlton Park in Ellsworth on Monday, Aug. 10, from 7:30-9 p.m.
Intermountain Health introduces new pancreatic cancer drug in western Colorado
Cancer center offering first-in-class treatment shown to more than double patients' expected length of life
For GLP-1 users, the in-store clothes shopping trip is back
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Tim Steller’s column: Grant Road businesses fold as construction adds to woes
For Star subscribers: The reconstruction of Grant Road is helping kill off Tucson businesses already weakened by street drug addiction and the sumer doldrums.
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Editorial: Pennsylvania health insurance rates need triage
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Diabetes Drug Used For More Than 60 Years Found to Unexpectedly Affect The Brain
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