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‘Plans to die in office': Bay Area congressman's ex-aides protest challenger's ads

Seven former staffers of Rep. Mike Thompson demand that challenger Eric Jones' campaign remove a commercial targeting the North Bay legislator.

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Oct 25 • 9:35 PM EDT • Politics • yahoo.com
Georgia lands son of music star in notable recruitment win

Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.

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Oct 25 • 9:26 PM EDT • Sports • sports.yahoo.com
🙂 Positive (65%)
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Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact

Los Angeles Lakers guard Luka Doncic recorded a 52-point double-double in the Lakers' 132-123 win over the Utah Jazz on Sunday. The post Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact appeared first on LA Sports Report.

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Oct 25 • 9:16 PM EDT • Sports • sports.yahoo.com
🙂 Positive (100%)
Dominant Doncic scores 52 as Lakers beat Jazz

Luka Doncic scored a monster 52 points as the Los Angeles Lakers maintained their perfect start to life after LeBron James with a 132-123 defeat of the Utah Jazz.From there Doncic and Reaves were relentless, outscoring the entire Jazz offense in the final quarter between them, as the new-look Lakers moved to a perfect 3-0 start.

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Oct 25 • 9:15 PM EDT • Sports • sports.yahoo.com
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Il Volo celebrates nearly 20 years of musical harmony

Longer than many marriages and most rock bands, the Italian singing trio Il Volo have been together for almost 20 years. They’ve gone from teenagers to 30-somethings while selling more

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Oct 25 • 9:00 PM EDT • Entertainment • floridaweekly.com
Iowa bishop says White House visit was 'exploited' for politics

Two Catholic bishops criticized how their White House visit was used after being told the gathering would be private.

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Oct 25 • 8:55 PM EDT • Politics • statesmanjournal.com
Iowa bishop says White House visit was 'exploited' for politics

Two Catholic bishops criticized how their White House visit was used after being told the gathering would be private.

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Oct 25 • 8:55 PM EDT • Politics • elpasotimes.com
Iowa bishop says White House visit was 'exploited' for politics

Two Catholic bishops criticized how their White House visit was used after being told the gathering would be private.

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Oct 25 • 8:55 PM EDT • Politics • usatoday.com
Corpus Christi Museum of Science and History turns Halloween into a hands-on learning experience for kids

The Corpus Christi Museum of Science and History made Halloween educational with hands-on activities, experts and a Mad Science Show.

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Oct 25 • 8:48 PM EDT • Science • kristv.com
Cubs Trade Of Edward Cabrera An Early Lose-Lose Deal

A high-stakes gamble for Edward Cabrera backfired in Chicago as the right-hander's metrics plummeted, leaving the North Siders searching for answers amidst a looming rotation crisis.

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Oct 25 • 8:39 PM EDT • Sports • sports.yahoo.com
How a movement of students brought down Serbia's Vučić

In just under two years the students have succeeded in tearing up 14 years of political dominance under Aleksandar Vučić.

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Oct 25 • 8:31 PM EDT • Politics • yahoo.com
Serbia's student movement: How and why students brought down Vučić

In just under two years the students have succeeded in tearing up 14 years of political dominance under Aleksandar Vučić.

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Oct 25 • 8:31 PM EDT • Politics • bbc.com
Simmons’ Behavior Shows Why Bieniemy Was Hired
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Oct 25 • 8:25 PM EDT • Sports • sports.yahoo.com
Four Positives From Frustrating Start To New Orleans Pelicans Season

These are some of the biggest positives to take away from the first few games of the New Orleans Pelicans' season.

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Oct 25 • 8:20 PM EDT • Sports • sports.yahoo.com
Wan'Dale Robinson held to seven yards in Week 7

Tennessee Titans wide receiver Wan'Dale Robinson posted four receptions for just seven yards in Week 7

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Oct 25 • 8:06 PM EDT • Sports • sports.yahoo.com
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo

BUTEMBO, Congo (AP) — A nurse was killed and a health worker severely injured after being attacked while responding to an Ebola alert in Congo, according to the World Health Organization.

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Oct 25 • 8:03 PM EDT • Health • wral.com
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Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo

The World Health Organization reports that a nurse has been killed and a health worker severely injured in an attack while responding to an Ebola alert in Congo. This attack,

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Oct 25 • 8:01 PM EDT • Health • oskaloosa.com
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Women Appear to Experience Psychedelic Drugs More Intensely, And We Don't Know Why

Same dose, different experience.

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Oct 25 • 8:00 PM EDT • Science • yahoo.com
Betting odds released for Michigan vs Rutgers

Can Michigan cover the spread versus Rutgers?

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Oct 25 • 7:56 PM EDT • Sports • sports.yahoo.com
Wizards rule out AJ Dybantsa for fourth-straight match

The NBA world will have to wait another night to see AJ Dybantsa's NBA debut.

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Oct 25 • 7:39 PM EDT • Sports • sports.yahoo.com
Zelenskyy says Putin’s statements on readiness for peace talks could be a ‘political trick’

Ukrainian president argues Russian intentions would become clear through its actions, readiness to reach agreements | Anadolu

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Oct 25 • 7:38 PM EDT • Politics • aa.com.tr
Marlins Could Adjust Their Attitude Toward Free Agency

The Fish can finance some free agent deals in 2026 with a few interesting names

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Oct 25 • 7:31 PM EDT • Sports • sports.yahoo.com
Vucic Concedes Electoral Defeat, Setting Stage For New Era Of Serbian Politics, Relations With West

Aleksandar Vucic, Serbia's former president and dominant political figure for more than a decade, conceded defeat to the student-led protest movement in the country's parliamentary elections, potentially ushering in a new era of politics more closely aligned with Europe and away from the Kremlin.

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Oct 25 • 7:15 PM EDT • Politics • rferl.org
😐 Neutral (17%)
Health network adding helicopter in rapid Pennsylvania expansion

WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System recently...

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Oct 25 • 7:15 PM EDT • Health • yahoo.com
Denzel Boston quiet in Week 7 road win vs. Titans

Cleveland Browns wide receiver Denzel Boston registered three receptions for 27 yards on eight targets in Week 7

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Oct 25 • 7:07 PM EDT • Sports • sports.yahoo.com
🙂 Positive (40%)
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Iowa family finds strength beyond the gym after cancer diagnosis

URBANDALE, Iowa (KCCI) -- Azariah Townsend can barely reach the pull-up bar in his family’s home gym in Urbandale, but he already knows strength is not measured by height.

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Oct 25 • 7:00 PM EDT • Health • wqow.com
Isaiah Likely disappoints in Week 7 vs. Texans

New York Giants tight end Isaiah Likely limited to two receptions for 12 yards on four targets in Week 7

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Oct 25 • 6:32 PM EDT • Sports • sports.yahoo.com
Matthew Stafford breaks Rams franchise record for touchdown passes

LAS VEGAS (AP) — Matthew Stafford added another milestone to his NFL career on Sunday, throwing his 155th touchdown pass for the Los Angeles Rams to break the franchise record.Stafford surpassed Roman Gabriel, who threw 154 TD passes for the Rams from 1962-72.

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Oct 25 • 6:11 PM EDT • Sports • sports.yahoo.com
MedStar Health expert warns parents about illnesses affecting teens and college students

CBS News Baltimore spoke with an expert at MedStar Health about common illnesses among teens and college students, including mononucleosis, strep throat and skin infections.

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Oct 25 • 6:08 PM EDT • Health • cbsnews.com
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The Next FRIDAY THE 13TH Movie Can Finally Fix An Infamous Mistake

We don’t know precisely when, but a new Friday the 13th movie is coming. After a 17-year drought, the franchise has come back to life, most recently with the release of Crystal Lake on Peacock, a show...

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Oct 25 • 6:00 PM EDT • Entertainment • yahoo.com
Ollie Gordon II surpasses 100-yard mark in Week 7

Dolphins RB Ollie Gordon II finishes with 103 rushing yards in Week 7 win

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Oct 25 • 5:55 PM EDT • Sports • sports.yahoo.com
Nico Collins disappoints in Week 7 vs. Giants

Houston Texans wide receiver Nico Collins posted two receptions for six yards on five targets in Week 7

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Oct 25 • 5:50 PM EDT • Sports • sports.yahoo.com
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift

The long-serving strongman leader of Serbia, Aleksandar Vucic, conceded defeat on Sunday in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government.

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Oct 25 • 5:50 PM EDT • Politics • cnn.com
Peoria business leader accused of DUI in deadly UTV crash

A business executive well known in the local sport community has been arrested on drunk driving accusations for a crash that killed a woman late Saturday night in rural Peoria County.

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Oct 25 • 5:48 PM EDT • Business • 25newsnow.com
Orlando Magic's Sean Sweeney Message to Paolo Banchero After Injury

As a grueling road trip looms, assistant coach Sean Sweeney challenges his squad to maintain their identity and intensity while navigating Paolo Banchero’s absence against elite competition.

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Oct 25 • 5:37 PM EDT • Sports • sports.yahoo.com
A Remarkable Place to Die: Trailer
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Oct 25 • 5:35 PM EDT • Entertainment • yahoo.com
'The Furious': Best-Reviewed Action Movie of 2026 Now Available to Stream
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Oct 25 • 5:32 PM EDT • Entertainment • yahoo.com
Bethenny Frankel reacts to Bravo ‘b----‘ Andy Cohen’s shady comments about her TikTok

Bethenny Frankel didn’t hesitate to clap back at ‘bitter’ Bravo boss Andy Cohen for his shady comment about her TikTok page.

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Oct 25 • 5:26 PM EDT • Entertainment • ew.com
Cam Skattebo confirms injury after Giants beat Texans in overtime

Cam Skattebo confirmed he did suffer an injury on his 42-yard overtime run.

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Oct 25 • 5:23 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Novant Health hosting Hilton Head hiring event Oct. 28

Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.

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Oct 25 • 5:22 PM EDT • Health • wtoc.com
😐 Neutral (2%)
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Everton’s five-game winning home run ended by Aston Villa

Everton’s five-match winning run at Goodison Park has come to an end with Aston Villa running out 3-2 winners on Merseyside this afternoon.Brian Sørensen enjoyed a successful return to his former c...

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Oct 25 • 5:10 PM EDT • Sports • sports.yahoo.com
🙂 Positive (50%)
Scott Walker’s The Drift will get under your skin

Walker’s 2006 album is unsettling, bizarre, and the perfect way to kill a party.

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Oct 25 • 5:08 PM EDT • Entertainment • theverge.com
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam

Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.

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Oct 25 • 4:42 PM EDT • Sports • sports.yahoo.com
Justin Jefferson limited to 44 yards in Week 7

Minnesota Vikings wide receiver Justin Jefferson had four receptions for a team-high 44 yards on seven targets in Week 7

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Oct 25 • 4:38 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-7%)
Four receptions for Chris Godwin Jr.

Buccaneers WR Chris Godwin Jr. leads team with four receptions in Week 7 win

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Oct 25 • 4:31 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office

You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.

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Oct 25 • 4:17 PM EDT • Entertainment • yahoo.com
Kyler Murray throws for 150 yards, TD in Week 7

Minnesota Vikings quarterback Kyler Murray completed 14 of 24 passes for 150 yards, one touchdown and no interceptions in Week 7

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Oct 25 • 4:16 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Kurt Warner Addresses Major Gaffe During Steelers Win vs. Saints

Kurt Warner knows Jaylen Warren’s name even better now. The former St. Louis Rams and Arizona Cardinals quarterback, who offered […]

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Oct 25 • 4:14 PM EDT • Sports • sports.yahoo.com
🙂 Positive (43%)
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Liverpool working towards deal for star; could reach €90m

Liverpool are reportedly in the mix for a very in-demand France star. They’re working towards a deal and it’s one that could cost €90m.Liverpool are weighing up their transfer targets for the up...

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Oct 25 • 4:10 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Is the Big 12 a two-bid CFP league? + 2-loss SEC playoff hopes + Lincoln Riley’s future at USC
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Oct 25 • 4:05 PM EDT • Sports • sports.yahoo.com
Michigan basketball gets reality check in exhibition loss vs Houston

Michigan writer Tony Garcia offers three observations from the Wolverines' 83-66 loss to Houston in its final exhibition.

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Oct 25 • 3:42 PM EDT • Sports • sports.yahoo.com
The Politics of Heaven ~ The Imaginative Conservative

The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans

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Oct 25 • 3:20 PM EDT • Politics • theimaginativeconservative.org
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again

Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.

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Oct 25 • 3:07 PM EDT • Sports • sports.yahoo.com
Puka Nacua active for Week 7 vs. Raiders

Los Angeles Rams wide receiver Puka Nacua is active for the Week 7 game

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Oct 25 • 3:05 PM EDT • Sports • sports.yahoo.com
Halloween evolved as a Frankenstein of cultural celebrations

The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.

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Oct 25 • 3:00 PM EDT • Entertainment • theshorthorn.com
Ravens lose standout rookie to injury against Bengals

The Baltimore Ravens have lost a key rookie to injury, forcing another change up front against the Cincinnati Bengals.

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Oct 25 • 2:59 PM EDT • Sports • sports.yahoo.com
How to watch the 2026 WNBA Finals: Golden State Valkyries vs. Atlanta Dream Game 5 time, schedule, where to stream and more
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Oct 25 • 2:46 PM EDT • Sports • sports.yahoo.com
😐 Neutral (13%)
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids

Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...

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Oct 25 • 2:28 PM EDT • Entertainment • yahoo.com
Top Japanese Prospect Has His Eyes on the Dodgers

The Los Angeles Dodgers are the industry favorite to sign the best prospect in Japan, 18-year old pitcher Shoki Oda.

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Oct 25 • 2:26 PM EDT • Sports • sports.yahoo.com
Opening Odds: Separating the real from the fake

Mizzou returns to action this week, and we’ll learn more if they’re real or fake.

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Oct 25 • 2:23 PM EDT • Sports • sports.yahoo.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Blanche told CNN's “State of the Union” that President Donald Trump, who said Friday that he was "the one that said do it,” is not trying to overturn state election results “in any way, shape or form” on the cusp of the Nov. 3 election.

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Oct 25 • 2:19 PM EDT • Politics • pbs.org
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

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Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.

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Oct 25 • 1:45 PM EDT • Health • seattletimes.com
Steelers stock report after Week 7 win over Saints

Stock up, stock down, after the Steelers Week 7 win in Paris over the New Orleans Saints.

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Oct 25 • 1:35 PM EDT • Sports • sports.yahoo.com
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina

Penalties, brain blips and a hangover conspire to doom Volunteers.

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Oct 25 • 1:33 PM EDT • Sports • sports.yahoo.com
Schefter: Seahawks among teams ‘expected to consider’ Jonathan Taylor trade

The Seahawks are “pondering” adding Taylor in hopes of saving their run game.

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Oct 25 • 1:32 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-10%)
BCM hosting special Nov. 13 show for America 250

BRISTOL — In partnership with The Crooked Road: Virginia’s Heritage Music Trail, Mountain Empire Children’s Choral Academy, and Theatre Bristol, the Birthplace of Country Music Museum is bringing together an

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Oct 25 • 1:30 PM EDT • Entertainment • therogersvillereview.com
😐 Neutral (0%)
J.J. McCarthy, Giants take 7-3 lead on Texans
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Oct 25 • 1:29 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Steelers Now Postgame: Steelers 16, Saints 10

Pittsburgh Steelers Postgame: Join Alan Saunders and Jobe Morrison after the Steelers’ Week 7 win over the Saints on YouTube, […]

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Oct 25 • 1:18 PM EDT • Sports • sports.yahoo.com
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'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
Carrick ‘not expecting’ Man United crisis talks despite Bournemouth defeat

Michael Carrick said he is ‘not expecting’ imminent talks about his future despite Manchester United’s latest defeat.Carrick’s position as head coach looks under threat after Manchester United...

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Oct 25 • 1:08 PM EDT • Sports • sports.yahoo.com
China Star Entertainment (SEHK:326) Stock Looks Richly Priced As Its 8.6x Run Continues

China Star Entertainment has logged very strong multi year share gains, so the key issue now is whether the current price can be supported by the value of assets on its balance sheet. For anyone looking at the stock today, the immediate question is how that share price lines up against its book value. Over the past 3 years the stock has returned about 8.6x. This puts a lot of weight on whether the underlying equity in the business justifies this kind of move when you compare it with the...

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Oct 25 • 1:06 PM EDT • Entertainment • finance.yahoo.com
Senate rivals seek support from Alaska Native voters

The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election

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Oct 25 • 1:03 PM EDT • Politics • latimes.com
3 Cubs Who Will Decline Their Options
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Oct 25 • 1:01 PM EDT • Sports • sports.yahoo.com
This Switch 2 sequel accessory was a few millimeters away from being good

The right stick gets in the way.

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Oct 25 • 1:00 PM EDT • Technology • theverge.com
NFL Week 7 Sunday afternoon open thread

Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia

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Oct 25 • 12:59 PM EDT • Sports • sports.yahoo.com
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois

Saturday's loss marked the third straight game in which Oregon scored under 20 points.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Broncos Place Linebacker, Running Back On Injured Reserve

The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Warren, Steelers stiff-arm Saints for 16-10 Paris win

Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.

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Oct 25 • 12:42 PM EDT • Sports • sports.yahoo.com
Saints Lose Defensive Battle in Paris Against Steelers

A very winnable game that a better team would have won.

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Oct 25 • 12:36 PM EDT • Sports • sports.yahoo.com
Orlando Science Center hosts Halloween party

Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.

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Oct 25 • 12:32 PM EDT • Science • wftv.com
Warriors honor Bay Area sports reporter Michael Wagaman

After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…

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Oct 25 • 12:30 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Browns injury update: Is Denzel Ward playing against the Titans?

The Browns will enjoy the presence of their top cornerback in Week 7.

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Oct 25 • 12:22 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Lakers’ Injury Report Rules Out Two Players for Jazz Game

Is Walker Kessler available in his return to Utah?

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Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
Week 7 inactives for Ravens

Baltimore declares five players inactive versus Cincinnati

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Oct 25 • 12:06 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Browns Week 7 inactives: Who's in, who's out?

The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.

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Oct 25 • 11:59 AM EDT • Sports • sports.yahoo.com
Astros should stay away from these 2 free agent outfielders

Astros shouldn't be interested in these two outfielders.

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Oct 25 • 11:58 AM EDT • Sports • sports.yahoo.com
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun

A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.

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Oct 25 • 11:55 AM EDT • Sports • sports.yahoo.com
Obama and Trump wage one last battle for even more urgent stakes

Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.

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Oct 25 • 11:45 AM EDT • Politics • cnn.com
Chivu: “The boys gave everything right to the end”

Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
Game Time Thread: Juventus vs. Lecce

MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens

The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.

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Oct 25 • 11:28 AM EDT • Sports • sports.yahoo.com
Robinson, Baker have tough talk about the offense

Robinson, Baker have tough talk about the offense

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Oct 25 • 11:15 AM EDT • Sports • sports.yahoo.com
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit

As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...

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Oct 25 • 11:08 AM EDT • Politics • yahoo.com
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.

Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.

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Oct 25 • 11:05 AM EDT • Health • cbc.ca
Jalen Duren out at least two weeks

Jalen Duren out at least two weeks

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Oct 25 • 11:04 AM EDT • Sports • sports.yahoo.com
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target

The M's certainly have a need for what Neto can provide.

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Oct 25 • 11:00 AM EDT • Sports • sports.yahoo.com