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UT Health San Antonio Multispecialty and Research Hospital treats first clinical trial participant in novel cancer study - UT Health San Antonio

Milestone paves the way for advancements in cancer care, innovation and patient care in San Antonio and South Texas. UT Health San Antonio Multispecialty and Research Hospital has enrolled and treated its first clinical trial participant in a novel cancer study, marking a pivotal moment for science and patient-centered cancer care in San Antonio and […]

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Mar 24 • 1:40 PM EDT • Health • news.uthscsa.edu
Mouse study shows repeated cloning causes grave genetic mutations

1,206 cloned laboratory mice were generated by the scientists from a single female donor mouse from 2005 to 2025 in research conducted in Japan.

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Mar 24 • 12:22 PM EDT • Science • detroitnews.com
Claude Code can now take over your computer to complete tasks

But Anthropic urges caution as "research preview" safeguards "aren't absolute."

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Mar 24 • 11:45 AM EDT • Technology • arstechnica.com
Subtle health changes may signal progressive supranuclear palsy years in advance

Drawing from UK Biobank data, Mass General Brigham researchers have uncovered specific health factors linked to higher or lower risk of developing progressive supranuclear palsy (PSP), a rare but devastating ...

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Mar 24 • 11:00 AM EDT • Health • medicalxpress.com
Brookdale Student Leana Vitale Turns Passion for Science into Research Success

Leana Vitale is proving that curiosity, determination, and hard work can open remarkable doors. A Brookdale student graduating this spring with two associate degrees in biology and chemistry, she has already distinguished herself as an

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Mar 24 • 10:47 AM EDT • Science • brookdalecc.edu
Anthropic’s Claude Code and Cowork can control your computer

Its only a research preview for now.

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Mar 24 • 9:32 AM EDT • Technology • theverge.com
Optical Vortex Phase Masks for the Detection of Habitable Worlds

A team of NASA researchers is developing new types of optical masks that could help enable the many orders of magnitude of starlight suppression needed for future space observatories to pick out very faint habitable exoplanets from the far brighter glare of their stellar hosts.

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Mar 24 • 9:00 AM EDT • Science • science.nasa.gov
Health care is reshaping the labor market

These days, health care is about more than caring for patients. In the past two years, this service industry has become the economy’s biggest creator of U.S. jobs.

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Mar 24 • 8:13 AM EDT • Health • adpresearch.com
Salamander Migration Has New Citizen Science Component

Each spring, blue-spotted salamanders emerge from their underground burrows at Presque Isle Park in Marquette and venture across the road to lay their eggs. Northern Michigan University students have been involved in conservation, data collection and public education efforts for this annual event, but this year, the general public is invited to play a more active role in salamander migration research. Northern Michigan University Biology Department Head Jill Leonard encourages community members to participate in the Marquette Citizen Science Project.

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Mar 24 • 8:00 AM EDT • Science • news.nmu.edu
Carbonsphere launches for carbon science and net-zero solutions

Tsinghua University Press is pleased to announce the launch of Carbonsphere, a new open-access, peer-reviewed journal dedicated to carbon science, technology, and policy. Sponsored by Qinghai University and Tsinghua University and published by Tsinghua University Press, the journal creates a new interdisciplinary platform for research spanning natural systems, engineered systems, and human systems.

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Mar 24 • 8:00 AM EDT • Science • eurekalert.org
US democracy has settled into diminished state, experts find

Bright Line Watch researchers see stabilization in democratic health but at lower levels after sharp decline

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Mar 24 • 7:00 AM EDT • Politics • theguardian.com
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We’ve Been Underestimating Flying Foxes

Australia used to incinerate the large fruit bats, but research suggests they bring hundreds of millions of dollars in benefits to the country’s economy.

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Mar 24 • 6:00 AM EDT • Science • nytimes.com
We’ve Been Underestimating Flying Foxes

Australia used to incinerate the large fruit bats, but research suggests they bring hundreds of millions of dollars in benefits to the country’s economy.

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Mar 24 • 6:00 AM EDT • Science • nytimes.com
Is social media addictive? The science reveals what’s at stake

The research into whether social media is addictive is nuanced and complex, with many unanswered questions

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Mar 24 • 6:00 AM EDT • Science • scientificamerican.com
How Bans on Corporate Political Donations Influence Campaign Platforms

Julia Cagé, Caroline Le Pennec, and Elisa Mougin discuss their recent research on France’s 1995 ban on corporate contributions to political campaigns. The ban pushed candidates to de-emphasize local politics in favor of national issues and, in many cases, adopt more extreme rhetoric.

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Mar 24 • 6:00 AM EDT • Politics • promarket.org
Special Battleground Report on Food and Health Part II: Messages

This Navigator Research report covers messaging guidance to effectively communicate on food and health-related issues to Americans in the battleground.

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Mar 24 • 4:45 AM EDT • Health • navigatorresearch.org
Old Wisdom, New Science, and the Tools of Tomorrow

How can firefighters navigate between the hard-earned practical wisdom of the past and modern technological developments? Scott Guillerault says fire research may point the way.

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Mar 24 • 4:02 AM EDT • Science • firefighternation.com
Scientists say NAD+ could slow aging and fight Alzheimer’s and Parkinson’s

A global team of leading scientists is zeroing in on a tiny but powerful molecule that could reshape how we age. Known as NAD⁺, it plays a crucial role in keeping our cells energized, repairing DNA, and maintaining overall health—but its levels steadily decline over time, potentially fueling diseases like Alzheimer’s and Parkinson’s. Researchers are now exploring ways to boost NAD⁺ using compounds like NR and NMN, with early studies hinting at improvements in memory, metabolism, and physical function.

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Mar 23 • 8:00 PM EDT • Science • sciencedaily.com
How Pixar Got the Science Right in Hoppers

Meet the researcher who informed the writers about beaver behavior and threats to their habitat

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Mar 23 • 8:00 PM EDT • Science • sierraclub.org
Supercomputers just solved a 50-year-old mystery about giant stars

Astronomers have finally cracked a decades-old mystery about red giant stars—how material from their deep interiors makes its way to the surface. Using cutting-edge supercomputer simulations, researchers discovered that stellar rotation plays a powerful role in mixing elements across a previously unexplained barrier inside the star.

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Mar 23 • 8:00 PM EDT • Science • sciencedaily.com
Insulin pills may soon replace daily injections

For over a century, scientists have chased the dream of insulin pills, but the digestive system kept destroying the drug before it could work—forcing millions of patients to rely on daily injections. Now, researchers at Kumamoto University have developed a clever workaround using a tiny peptide that helps insulin slip through the intestinal wall.

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Mar 23 • 8:00 PM EDT • Science • sciencedaily.com
Mediterranean diet may boost mitochondrial signals linked to heart and brain health

A study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondria, ...

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Mar 23 • 7:40 PM EDT • Health • medicalxpress.com
Can pesticide exposure before pregnancy affect babies’ health?

A study co-authored by UCLA researchers suggests certain chemical compounds correlated with lower newborn health scores.

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Mar 23 • 7:33 PM EDT • Health • newsroom.ucla.edu
The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi

Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat

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Mar 23 • 6:35 PM EDT • Science • newswise.com
Microsoft hires former Ai2 CEO Ali Farhadi and key researchers for Suleyman’s AI team

Microsoft is hiring former Ai2 CEO Ali Farhadi, along with Hanna Hajishirzi and Ranjay Krishna from the Allen Institute for AI to join Mustafa Suleyman's Superintelligence team, GeekWire has learned.

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Mar 23 • 6:32 PM EDT • Technology • geekwire.com
NASA Data Hackathon Inspires Community Action

On Jan. 31, students, library staff, researchers, and community members gathered at the University of Florida’s (UF) Marston Science Library for the

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Mar 23 • 5:30 PM EDT • Science • science.nasa.gov
Someone has publicly leaked an exploit kit that can hack millions of iPhones

Leaked "DarkSword" exploits published to GitHub allow hackers and cybercriminals to target iPhone users running old versions of iOS with spyware, according to cybersecurity researchers.

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Mar 23 • 4:42 PM EDT • Technology • techcrunch.com
Shorebird science and conservation collective shows big data can protect birds

New research from the Shorebird Science and Conservation Collective at the Smithsonian's National Zoo and Conservation Biology Institute (NZCBI), published in the journal Conservation Biology, provides ...

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Mar 23 • 4:40 PM EDT • Science • phys.org
Chemistry student develops clear polish that turns your fingernail into a touch-screen stylus

Researchers have developed a prototype nail polish to help more people access electrically-charged touch screens.

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Mar 23 • 4:25 PM EDT • Technology • livescience.com
A geneticist is studying pythons for clues about human health and longevity

A team of researchers believes that pythons may contain clues to help treat a range of human ailments — from heart disease to muscle atrophy, and more.

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Mar 23 • 4:03 PM EDT • Health • npr.org
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Formulating a Future: Finding a Calling in Pharmaceutical Science | Oberlin College and Conservatory

Chemistry major Alex Xie ’26 utilizes CELA’s research fellowships and scholarship advising to transition from campus labs to a future in pharmaceutical research.

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Mar 23 • 1:19 PM EDT • Science • oberlin.edu
Finishing a video game can trigger “post-game depression,” study finds

Post-game depression is now being studied as a measurable phenomenon, with researchers identifying how finishing a video game can leave players feeling empty, reflective, and emotionally drained.

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Mar 23 • 10:38 AM EDT • Technology • dexerto.com
Shorebird Science and Conservation Collective Shows Big Data Can Protect Birds

New research published in the journal Conservation Biology provides a model for big data to inform conservation.

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Mar 23 • 10:00 AM EDT • Science • nationalzoo.si.edu
Watch sperm whale headbutt another for no apparent reason

Researchers have captured extraordinary footage of sperm whales randomly headbutting each other, confirming anecdotal reports from mariners and whalers in the 18th and 19th centuries.

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Mar 23 • 9:56 AM EDT • Science • livescience.com
Welcome, American scientists: Europe, a haven for researchers struggling under Trump

Initiatives are multiplying in EU countries including France, Germany and Austria to attract the talent being driven away by the US president’s policies

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Mar 23 • 9:12 AM EDT • Science • english.elpais.com
WSU launches bilingual video series to help beekeepers improve colony health

Researchers with WSU's Honey Bee and Pollinators Program have produced a new video series giving novice keepers a strong introduction to best practices and the science of apiculture, in both Spanish and English.

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Mar 23 • 9:00 AM EDT • Health • news.wsu.edu
A surprising foam discovery could change everyday products

Foams have long baffled scientists because liquid drains from them far sooner than theory predicts. New research shows the reason: the bubbles don’t stay put—they rearrange, opening pathways for liquid to escape. The key factor is the pressure needed to shift bubbles, not just push liquid through them. This insight reshapes how we understand foams and could improve everyday products.

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Mar 23 • 8:00 AM EDT • Science • sciencedaily.com
Inaugural Health Care by Food research award honors excellence in food is medicine science

DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...

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Mar 23 • 8:00 AM EDT • Science • newsroom.heart.org
Funny business: Humor scholars on whether jokes help or hurt at work

Leeds researchers Tony Kong and Peter McGraw agree humor has real workplace benefits, but pulling it off can be tricky.

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Mar 23 • 8:00 AM EDT • Business • colorado.edu
Inaugural Health Care by Food research award honors excellence in food is medicine science

DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...

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Mar 23 • 8:00 AM EDT • Health • newsroom.heart.org
10 Surprising Perimenopause Symptoms That Are More Common Than Hot Flashes, According to New Research

Think perimenopause is just about hot flashes? Check out these very common other menopause symptoms.

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Mar 23 • 8:00 AM EDT • Health • health.com
Stealth BioTherapeutics Announces MRC Business Engagement Fund Grant to Advance Mitochondrial Disease Research

/PRNewswire/ -- Stealth BioTherapeutics (the "Company"), a commercial-stage biotechnology company focused on the discovery, development, and commercialization...

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Mar 23 • 8:00 AM EDT • Business • prnewswire.com
What’s the science behind ice thickness and when it’s safe to drive on a lake?

A Canadian ice researcher came up with a formula in 1971 for ice roads. It’s still the foundation for safety guidelines.

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Mar 23 • 7:00 AM EDT • Science • startribune.com
Closing the women’s health gap: 5 key focus areas and why they need more research

Only 6% of private investment targets women's health, a World Economic Forum report says. 5 examples show how strategic investments could change this.

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Mar 23 • 6:44 AM EDT • Health • weforum.org
Women’s health innovation is a huge opportunity Philadelphia is in danger of missing

A booming medical market is creating jobs, research and startup funding, and the region has the talent and institutions to become a national leader, a local entrepreneur writes.

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Mar 23 • 6:00 AM EDT • Health • technical.ly
Where There’s Wildfire Smoke, There’s Poor Mental Health

Research has increasingly connected wildfire and smoke with worsening mental health, partly due to damage in the brain.

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Mar 23 • 3:46 AM EDT • Health • undark.org
Funding for populist-right ‘media-political complex’ exceeded £170m in five years, research finds

Handful of billionaires gave huge sums in particular to media organisations that boosted rightwing politicians, says Liam Byrne MP

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Mar 23 • 1:00 AM EDT • Politics • theguardian.com
A promising fatty liver treatment may raise cancer risk

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.

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Mar 22 • 8:00 PM EDT • Science • sciencedaily.com
Science diplomacy, research and global health

Nature Microbiology - As a young scientist from the global south, engaging in science diplomacy has brought greater purpose and meaning to my career, writes Delfina Fernandes Hlashwayo.

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Mar 22 • 8:00 PM EDT • Science • nature.com
Science diplomacy, research and global health

Nature Microbiology - As a young scientist from the global south, engaging in science diplomacy has brought greater purpose and meaning to my career, writes Delfina Fernandes Hlashwayo.

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Mar 22 • 8:00 PM EDT • Health • nature.com
Cockroaches with smart backpacks? Scientists turn insects into cyborgs to detect hidden pipeline leaks

Science News: Although the concept seems like something from science fiction, science is rapidly adopting it. Researchers have started creating ‘cyborg cockroaches,.

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Mar 22 • 4:30 PM EDT • Science • timesofindia.indiatimes.com
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Student researchers bring Kentucky State University science to Posters-at-the-Capitol

With lawmakers just steps away, three Kentucky State University undergraduates presented research on cattle health, soil amendments and food safety at the Capitol Annex on March 5, bringing student-led agricultural […]

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Mar 22 • 3:00 PM EDT • Science • state-journal.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Rising toll: Are NC sports betting protections enough?

With two years of legalized sports betting in the books, public health advocates, researchers and counselors suggest changes.

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Mar 22 • 9:55 AM EDT • Sports • wunc.org
Scientists discover surprising brain trigger behind high blood pressure

Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Scientists twisted a mysterious superconductor and got a shocking result

A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
'Education and communication key to voter turnout' in Jersey

Researcher says more work is needed to increase Jersey's low voter numbers.

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Mar 22 • 3:26 AM EDT • Politics • bbc.com
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New Research Shows the 6 Skills You Need to Master Anything

Scientists explain why some of us benefit more than others from expert guidance.

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Mar 21 • 11:32 PM EDT • Science • outsideonline.com
Friction without contact discovered as magnetic forces break a 300-year-old law

Researchers have uncovered friction without contact—driven entirely by magnetic interactions. As two magnetic layers slide, their internal forces compete, causing constant rearrangements that dramatically increase resistance at certain distances. This creates a surprising peak in friction instead of a steady rise, breaking a long-standing physics law.

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
Webb Telescope spots “impossible” atmosphere on ancient super Earth

Astronomers have uncovered surprising evidence of a thick atmosphere surrounding TOI-561 b, a scorching, fast-orbiting rocky planet once thought too extreme to hold onto any gas. Using NASA’s James Webb Space Telescope, researchers found the planet is far cooler than expected for a bare rock, hinting at a heat-distributing atmosphere above a churning magma ocean. This strange world—where a year lasts just over 10 hours and one side is locked in eternal daylight—may even be rich in volatile materials, behaving like a “wet lava ball.”

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
More school-based health clinics fill growing needs

An increase in school-based health clinics is sweeping the states of Ohio and Michigan, following research that grounds positive health outcomes for ...

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Mar 21 • 8:00 PM EDT • Health • toledoblade.com
Sanford Sports launches in Black Hills region

Sanford Sports is expanding into the Black Hills, bringing its research-backed training programs and services to athletes across the region.

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Mar 21 • 7:00 PM EDT • Sports • kotatv.com
Scientists Recruit Undergrad to Step Into Room Filled With Ravenous Mosquitoes for “Full-Body Massacre”

Researchers at Georgia Tech used undergraduate student Chris Zuo as bait in trials to study mosquito flight behaviors.

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Mar 21 • 2:00 PM EDT • Science • futurism.com
NCDHHS launches new program looking to expand number of mental health providers in state

In North Carolina, the demand for social workers in the state is growing as substance use and mental health service needs increase. The North Carolina Department of Health and Human Services launched the Public Service Leadership Program, a collaboration between the NCDHHS and 25 higher education institutions in the Social Work Coalition on NC Work Development, to help with that demand.Alongside the announcement of the new program on March 2, the NCDHHS released its first “State of North Carolina’s Mental Health and Substance Use Services Workforce Report” supported by UNC’s Behavior Health Workforce Research Center and Sheps Health Workforce NC.

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Mar 21 • 12:53 PM EDT • Health • elonnewsnetwork.com
Particle Breakthrough: South Dakota scientists help unlock new neutrino mystery

Scientists at South Dakota Mines help achieve the first-ever measurement of a rare neutrino interaction, advancing physics and supporting future research at SURF.

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Mar 21 • 12:00 PM EDT • Science • kotatv.com
A massive freshwater reservoir is hiding under the Great Salt Lake

A hidden freshwater system deep beneath the Great Salt Lake has been revealed using airborne electromagnetic surveys. Scientists found that freshwater extends much farther under the lake than expected, reaching depths of up to 4 kilometers. The discovery began with mysterious reed-covered mounds formed by pressurized groundwater pushing upward. Researchers are now investigating whether this underground water could help control hazardous dust from the drying lakebed.

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Mar 21 • 8:00 AM EDT • Science • sciencedaily.com
NASA’s Hubble accidentally caught a comet breaking apart in real time

In an incredibly lucky cosmic accident, NASA’s Hubble Space Telescope captured a comet breaking apart in real time—something astronomers have long tried and failed to observe. The comet, C/2025 K1 (ATLAS), wasn’t even the original target, but when researchers pivoted to it, they unknowingly caught it mid-disintegration into multiple pieces.

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Mar 21 • 8:00 AM EDT • Science • sciencedaily.com
Ancient DNA reveals a farming shift that pushed a society to the brink

A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.

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Mar 21 • 8:00 AM EDT • Science • sciencedaily.com
Why are humans the only species with a chin?

Potential explanations abound, yet recent research has shed new light on the question.

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Mar 21 • 5:00 AM EDT • Science • livescience.com
How the US Is Squandering Its Science and Technology Advantage

The Trump administration’s cuts to research and development (R&D) and opposition to international student visas will have disastrous effects on US technological competition with China.

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Mar 21 • 3:05 AM EDT • Science • nationalinterest.org
Scientists just found a hidden 48-dimensional world in quantum light

A routine quantum optics technique just revealed an extraordinary secret: entangled light can carry incredibly complex topological structures. Researchers found these hidden patterns reach up to 48 dimensions, offering a vast new “alphabet” for encoding quantum information. Unlike previous assumptions, this topology can emerge from a single property of light—orbital angular momentum.

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Mar 20 • 8:00 PM EDT • Science • sciencedaily.com
New AI tool predicts cancer spread with surprising accuracy

Researchers have discovered that cancer spread isn’t random—it follows a kind of biological “program.” By studying colon tumor cells, they identified gene patterns that signal whether a cancer is likely to metastasize. Their AI model, MangroveGS, can predict this risk with about 80% accuracy and even works across multiple cancer types. This could transform how doctors decide who needs aggressive treatment and who doesn’t.

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Mar 20 • 8:00 PM EDT • Science • sciencedaily.com
Scientists turn probiotic bacteria into tumor-hunting cancer killers

Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.

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Mar 20 • 8:00 PM EDT • Science • sciencedaily.com
David Botstein, Gene-Mapping Pioneer, Dies at 83

His method of locating genes in human DNA allowed researchers to find disease-causing genes, and later to map the entire, sprawling human genome.

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Mar 20 • 5:25 PM EDT • Science • nytimes.com
New study links more immigrants with lower elderly mortality

Researchers say among newcomers are medical, long-term care workers who are arriving amid critical U.S. shortage.

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Mar 20 • 3:15 PM EDT • Health • news.harvard.edu
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Charleston Waterkeeper opens Community Science Lab for researching water quality, monitoring microplastics

CHARLESTON, S.C. (WBCD) — Charleston Waterkeeper has opened a first-of-its-kind Community Science Lab, inviting residents, students, and volunteers to take a hands-on role in monitoring Lowcountry wat...

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Mar 20 • 2:13 PM EDT • Science • yahoo.com
Seattle’s biotech scene is world-class — Life Science Washington is teaching it how to brag

Despite world-class AI-biotech research, a Nobel Prize-winning protein design lab and proximity to global AI expertise, Washington's life sciences sector is still learning to tell its story.

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Mar 20 • 12:49 PM EDT • Science • geekwire.com
Rival ‘shadow’ group to RFK, Jr.’s autism science committee meets in D.C.

Autism researchers are working to counter a federal autism advisory panel that has vaccine skeptic members and, they say, a “striking absence of scientific expertise”

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Mar 20 • 12:45 PM EDT • Science • scientificamerican.com
New controls can stretch, blur and even reverse quantum time flow

In new research published in Physical Review X, scientists have designed quantum control protocols that generate processes more consistent with time flowing backward than forward. The protocols—techniques ...

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Mar 20 • 12:40 PM EDT • Technology • phys.org
Week Wraps with Health Research and Spacewalk Closeout Procedures

Health research and final spacewalk closeouts wrapped up the week for the Expedition 74 crew members aboard the International Space Station as they gear up to

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Mar 20 • 11:50 AM EDT • Health • nasa.gov
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AI is running rampant in health care. They want to fix that.

Researchers at Northeastern are creating a universal guide for how to ethically implement AI in health care.

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Mar 20 • 11:22 AM EDT • Health • news.northeastern.edu
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Men are losing a key chromosome with age and it may be deadly

Aging men often lose the Y chromosome in a growing number of their cells—and it may be far more dangerous than once believed. This loss has been linked to heart disease, cancer, Alzheimer’s, and shorter lifespans. Researchers suspect Y-less cells may grow faster and disrupt normal body functions. What seemed like a minor genetic quirk could actually be a major driver of age-related disease.

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Mar 20 • 8:00 AM EDT • Science • sciencedaily.com
Abramson advancing research at intersection of health, inequality and AI

Corey Abramson's research earns him a year in residence at the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University.

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Mar 20 • 8:00 AM EDT • Health • news.rice.edu
The Problem With Promoting ‘Gold Standard Science’

Opinion | Branding scientific research with a simplified label risks misleading the public and harming scientific literacy.

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Mar 20 • 5:00 AM EDT • Science • undark.org
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Rising toll: Are NC sports betting protections enough?

With two years of legalized sports betting in the books, public health advocates, researchers and counselors suggest changes.

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Mar 20 • 4:22 AM EDT • Sports • northcarolinahealthnews.org
Researcher: Addressing runaway college sports spending in Virginia

This whole college sports enterprise is business development that is being financed by student subsidies, and frequently ever higher student loan debt. As a society, do we do this for any other fo…

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Mar 20 • 4:00 AM EDT • Sports • cardinalnews.org
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Verdict on Chatbots in Mental Health Screenings? Too Judgmental

Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered a neutral option for sharing mental health concerns. In a recent test of these common assumptions, however, a University of Texas at Dallas researcher […]

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Mar 19 • 11:00 PM EDT • Health • news.utdallas.edu
Scientists turn CO2 into fuel using breakthrough single-atom catalyst

Researchers have created a cutting-edge catalyst that turns CO2 into methanol more efficiently than ever before. Instead of using clumps of metal atoms, they engineered a system where each single indium atom actively drives the reaction. This dramatically reduces energy needs while making the process easier to study and optimize. The result could accelerate the shift toward cleaner fuels and sustainable chemical production.

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Mar 19 • 8:00 PM EDT • Science • sciencedaily.com
Sense of belonging predicts who stays in science

New research shows that feeling connected to a scientific community may be key to reducing attrition, with professional societies positioned to strengthen belonging across disciplines.

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Mar 19 • 7:01 PM EDT • Science • news.vt.edu
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Fusion scientists face challenges in effort to produce reliable energy source

‘Special Report’ anchor Bret Baier reports on scientific research attempting to create fusion as a source of reliable energy and how artificial intelligence could help.

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Mar 19 • 6:59 PM EDT • Science • foxnews.com
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Many Americans plan to cut food to afford ACA health insurance, new poll shows

About 8 in 10 Americans who re-enrolled in Affordable Care Act marketplace coverage say their health care costs are higher this year, according to a new survey from the health care research nonprofit KFF.

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Mar 19 • 6:58 PM EDT • Health • pbs.org
2026 March Madness: What Makes an NCAA Tournament Champion?

March Madness is here, and FOX Sports Research has done a historical deep-dive into the characteristics that make up a tournament champion.

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Mar 19 • 5:25 PM EDT • Sports • foxsports.com
Analyst: Foldable iPhone Likely to Ship in December, iPhone 18 Plus is Possible Next Year

In a research note for investment bank Barclays earlier this month, Apple analyst Tim Long said his supply chain sources mentioned the possibility of the iPhone 18 base model being announced in March next year, rather than in September this year. This split launch has been widely rumored by multiple sources in recent months. More interestingly, Long dropped two unique pieces of information.

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Mar 19 • 3:27 PM EDT • Technology • macrumors.com
An experimental AI agent broke out of its testing environment and mined crypto without permission

Researchers discovered that an AI agent roamed beyond its parameters, creating backdoors in IT infrastructure.

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Mar 19 • 11:00 AM EDT • Science • livescience.com
Varying your exercise routine could add years to your life

Switching up your exercise routine does more than fight boredom. Engaging in varied forms of movement may significantly boost your longevity, according to research.

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Mar 19 • 10:39 AM EDT • Health • cnn.com
Looking for Answers Before Birth: How 2 UT Health Sciences Researchers Are Re-examining Childhood Obesity

Childhood obesity is often framed as a problem of habits, including what children eat, how much they move, and the environments in which they grow up.

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Mar 19 • 10:00 AM EDT • Health • news.uthsc.edu
RFK Jr. makes food sound like a miracle drug. Researchers say he often overstates the science

In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and…

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Mar 19 • 9:02 AM EDT • Science • wtop.com
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RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science

In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...

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Mar 19 • 9:02 AM EDT • Science • usnews.com
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science

In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...

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Mar 19 • 9:02 AM EDT • Health • usnews.com
The best strength training plan might be simpler than you think

New strength training guidelines emphasize that doing any resistance training is what truly matters. Based on decades of research, experts say even simple routines can increase muscle, strength, and physical function. The key is not perfection but consistency. In fact, the best workout plan is the one you can maintain long term.

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Mar 19 • 8:00 AM EDT • Science • sciencedaily.com