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Formulating a Future: Finding a Calling in Pharmaceutical Science | Oberlin College and Conservatory
Chemistry major Alex Xie ’26 utilizes CELA’s research fellowships and scholarship advising to transition from campus labs to a future in pharmaceutical research.
Women's March Madness live updates, scores, results: Alabama leads Louisville in tightly contested first half; UConn, South Carolina, UCLA back in action Monday
Cargo Headed to Station, Week Begins with Science Prep and Maintenance
A cargo spacecraft is in orbit catching up to the International Space Station for a docking tomorrow to deliver food and supplies to the Expedition 74 crew. Aboard the orbital lab, the seven residents kicked off the week with science operations prep, routine maintenance, and getting systems ready for a future spacewalk.
Firefox 149 Now Available With XDG Portal File Picker, Rust-Based JPEG-XL Decoder
Firefox 149.0 release binaries are now available with a wide assortment of improvements for this month's update to the cross-platform Mozilla web browser solution.
Grub Lab: $6 Million Raised To Bring Sports And Entertainment IP To Independent Restaurants Nationwide
Grub Lab, an Australia-founded restaurant technology startup, announced it has raised $6 million in funding from Quantaco to accelerate its expansion across the United States and support a national rollout tied to major sports leagues and entertainment studios. The company is positioning itself as a modern solution to help independent restaurants compete for family dining traffic through interactive, branded experiences.
PATLABOR the Case Files announced for PS5, PC
Publisher Good Smile Company and developer Chime Corporation have announced 3D action game PATLABOR the Case Files
‘Anyone but Labour’ or ‘anyone but Reform’? Clash of animosities likely to define May local elections
While Labour braces for a rout that could see off Starmer, a rising drive to keep out Farage is complicating expectations
Simona Martin: Colorado’s data center boom needs public health guardrails
As AI infrastructure expands across the state, lawmakers face a choice about who bears the costs and risks.
A DNA test ruled him out. He was convicted of murder anyway.
Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.
Alabama vs. Texas Tech odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model
SportsLine's model has revealed its Texas Tech vs. Alabama picks for the NCAA Tournament 2026 second-round game on Sunday
UFL team signs former Alabama high school, Crimson Tide QB
The Thompson High School alumnus had been scheduled to play in the Indoor Football League on Sunday.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Inside a rare lab that's blazing a bold trail as it hunts for new drugs
A scientist from Zambia who loves — LOVES! — chemistry runs a lab in South Africa that is being hailed for "extraordinary" work.
Inside a rare lab that's blazing a bold trail as it hunts for new drugs
A scientist from Zambia who loves — LOVES! — chemistry runs a lab in South Africa that is being hailed for "extraordinary" work.
German club Borussia Dortmund parts ways with sports director Kehl
German football club Borussia Dortmund said on Sunday it is ending its collaboration with sports director Sebastian Kehl with immediate effect.
OU women's gymnastics senior Faith Torrez scores perfect 10, while Sooners lose in SEC championship
No. 1 OU women’s gymnastics (18-1-1) finished second in the Southeastern Conference Championship against No. 3 Florida (15-2-0), No. 2 LSU (12-5-1) and No. 4 Alabama (9-8-0) Saturday, with the
Healthy Kids Day collaboration with PTO Science Night, April 17
FROM FACEBOOK__Get ready for an action-packed evening! This year, the Bluffton YMCA Healthy Kids Day is joining forces with the Bluffton Schools PTO Science Night for one massive community event!
Fourth suspected measles case reported in Washtenaw County
Measles has not yet been confirmed with laboratory testing, according to a health department press release.
Robert Mueller, ex-FBI director at center of political tempest, dies at 81
After building a reputation for quiet rectitude, he became a political target as special counsel investigating Russian interference in the 2016 election.
City of Santa Barbara Seeks Nominations for 2026 Business in Art Award
Nominations are now open for the 2026 City of Santa Barbara Business in Art Award, for local businesses that support artists
NCDHHS launches new program looking to expand number of mental health providers in state
In North Carolina, the demand for social workers in the state is growing as substance use and mental health service needs increase. The North Carolina Department of Health and Human Services launched the Public Service Leadership Program, a collaboration between the NCDHHS and 25 higher education institutions in the Social Work Coalition on NC Work Development, to help with that demand.Alongside the announcement of the new program on March 2, the NCDHHS released its first “State of North Carolina’s Mental Health and Substance Use Services Workforce Report” supported by UNC’s Behavior Health Workforce Research Center and Sheps Health Workforce NC.
County Proposes Eliminating Preschool for All’s Early Childhood Mental Health Team
Unlike other cuts being made across the county in light of a budget shortfall, the decision to disband the team comes as Preschool for All sits on more than $600 million. The county says the proposed change is not driven by available funding.
Calculate Your VO2 Max at Home in Just 5 Minutes, No Complex Lab Tests Needed
It's one of endurance sport's most talked about yet elusive numbers, until now. A simple power test will spare you a costly trip to a performance lab for specialist VO2 Max testing.
GOP, Dems battle over Trump's SAVE Act. But who will it really help?
The president says the election security bill 'will guarantee the midterms' for Republicans. Available data is far less clear cut. Here's why.
Alabama's Tyler Fay pitches no-hitter against Florida
Tyler Fay pitched Alabama's first nine-inning, complete-game no-hitter in 84 years, striking out 13 in a 6-0 victory over Florida on Friday night.
Skagit adds dozens of voluntary inpatient beds for mental health and detox
The new 48-bed facility in Sedro-Woolley is a project of the cross-county North Star collaboration
Why the Trump administration is easing sanctions on certain Iranian oil stockpiles
Trump administration officials are making a desperate push to secure every available barrel of oil amid a worsening energy crisis — even if it means lifting sanctions on the very country that they’re fighting against.
Press Release - Girls in STEM Program from Keystone Science School
Delivered in an all-girl+ learning environment, Keystone Science School’s Girls in STEM programs encourage participation, collaboration, leadership, and confidence.
Reparations Committee opens up applications for Black Business grant program
The city’s Reparation Committee, in collaboration with Oakton College, is launching a grant and training program to support Black entrepreneurs at
Charleston Waterkeeper opens Community Science Lab for researching water quality, monitoring microplastics
CHARLESTON, S.C. (WBCD) — Charleston Waterkeeper has opened a first-of-its-kind Community Science Lab, inviting residents, students, and volunteers to take a hands-on role in monitoring Lowcountry wat...
Another Planet Entertainment Producing Free Show Celebrating 30 Years of OM Records
Longtime dance label OM Records is celebrating its 30th anniversary with a free concert produced by Another Planet Entertainment.
Seattle’s biotech scene is world-class — Life Science Washington is teaching it how to brag
Despite world-class AI-biotech research, a Nobel Prize-winning protein design lab and proximity to global AI expertise, Washington's life sciences sector is still learning to tell its story.
Apple to Launch More New Hardware This April
Apple isn't done yet. After announcing seven new products in March – including the iPhone 17e, iPad Air, MacBook Air, MacBook Pro, MacBook Neo, Studio Display, and Studio Display XDR – the company has one more launch on the books in the coming weeks (as far as we know, at least). AirPods Max 2 go up for pre-order on March 25, with availability beginning in early April.
Christy Carlson Romano says 'Even Stevens' costar Shia LaBeouf 'doesn't deserve' Disney GOAT status
Christy Carlson Romano is firing shots at her old 'Even Stevens' costar Shia LaBeouf's direction, agreeing with Demi Lovato that LaBeouf 'doesn't deserve' to be counted among the all-time Disney Channel greats.
Player availability report, presented by Orlando Health Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Denver Summit
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Denver Summit
“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
The Problem With Promoting ‘Gold Standard Science’
Opinion | Branding scientific research with a simplified label risks misleading the public and harming scientific literacy.
NYC health budget plan: More support for children, less for fighting disease
The $2.51 billion spending plan includes increases for early childhood initiatives and a new public health lab - but less funding to fight communicable diseases, sexually transmitted infections, and tuberculosis.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Yale Surgery Launches Health Career Collaborative–New Haven to Mentor Local High School Students
The Department of Surgery has launched the Health Career Collaborative (HCC)–New Haven, a mentorship program connecting local high school students with surgeons
Political influence ‘a serious problem’ for FDA under Trump, former commissioner says
Hundreds of individualized treatments for rare diseases could become available over the next decade — but only if government regulators handle the new
<em>Pokémon Horizons: Season 3—Rising Hope</em> Part 2 Available on Netflix
The adventure continues in Pokémon Horizons: Season 3—Rising Hope Part 2 on Netflix.
Which former Falcons are still available in NFL free agency?
Kirk Cousins, Leonard Floyd among former Falcons available in free agency
Planet Labs’ stock soars as the satellite company says AI will unlock more business
The company, a Google partner, delivered record revenue for its latest fiscal year, reflecting growing demand for satellite imagery.
Justin Bieber and Usher had "heated exchange" at Beyoncé, Jay-Z's Oscars after-party (Report)
The longtime friends and collaborators got into a "heated exchange" following the Academy Awards, TMZ reports.
City of Santa Barbara Seeks Nominations for 2026 Business in Art Award
Credit: CourtesyCredit: Courtesy (SANTA BARBARA, Calif.) – Nominations are now open for the 2026 City of Santa Barbara Business in Art Award, which
Bungie Reveals All Details of Marathon's First Raid, Cryo Archive; Goes Live on March 20 and Weekends Only
Here's everything you need to know about Marathon's Cryo Archive raid that goes live on March 20, which will only be available on weekends.
Curis Provides Fourth Quarter 2025 Business Update
Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of emavusertib (CA-4948), an orally available, small molecule IRAK4 and FLT3 inhibitor, today reported its business update and financial results for the quarter ended December 31, 2025.
Curis Provides Fourth Quarter 2025 Business Update
/PRNewswire/ -- Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of emavusertib (CA-4948), an orally available, small molecule...
Hochul wants new state commission to study AI effect on N.Y. economy
As of December, the state’s unemployment rate stood at 4.6%, according to state labor department statistics.
Green Bay Packers officially announce full 2026 coaching staff
Expect the Green Bay Packers to run a 3-4 defense in 2026. Everything is trending that way, including staff titles
Business Briefs: Funding available for Rockwood storefronts
Rockwood storefront improvement grants Funds are available to freshen businesses across the Rockwood Urban Renewal Area. The storefront improvement grants aim to boost property values, improve perceptions of safety, increase […]
Google details new 24-hour process to sideload unverified Android apps
The "advanced flow" will be available before verification enforcement begins later this year.
Accenture Collaborates with Microsoft to Bring Agentic Security and Business Resilience to the Front Lines of Cyber Defense
NEW YORK, March 19, 2026--Accenture today announced new assets and capabilities for its Adaptive Managed Extended Detection and Response (MxDR).
Basketball Classics now available for Xbox Series, PS4, Xbox One, and Switch
8-bit basketball game Basketball Classics is now available for Xbox Series, PlayStation 4, Xbox One, and Switch for $9.99 with a 10 percent-off launch discount, publisher Acclaim and developer Namo…
Blue Jays Receive Unfortunate Health Update On Right-Hander Trey Yesavage
Yesavage won't be available at the start of the 2026 season.
Equine Business Code Draft Update now available, survey open
The Washoe County Planning Division has completed a draft of the equine business code, which is available online and can be viewed here: Equine Business Annotated Draft. Planners will host several opportunities in the coming weeks to provide feedback on the draft code. The first is an Equine Business Code Update Webinar that will review the equine business code update process so far, what […]
Why Generative AI Threatens Creative Roles In Media And Entertainment
Generative AI is bound to shrink the labor market for creatives, according to this task-technology fit analysis, by making them more efficient and by supplanting them.
Xiaomi releases new lightweight laptop with Intel Panther Lake and 120 Hz OLED display
Xiaomi has released a new 14-inch laptop featuring Intel's Panther Lake platform. Available with up to 32 GB of RAM, the Book Pro 14 combines a 120 Hz OLED display with 72 Wh battery inside a housing that tips the scales at barely over a kilo.
International Arctic delegation gets crash course on Fairbanks politics
More than 20 dignitaries are visiting the Fairbanks North Star Borough this week as part of an European Union-sponsored initiative to foster collaboration among Arctic nations.
German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
Women in Medicine and Science Research Day Highlights Achievements and Opportunities
The 20th annual Women in Medicine & Science Research Day on March 11 offered opportunities for community-building, networking, mentoring and collaboration.
State forensic science commission blasts UIC over rogue crime lab
The Illinois Forensic Science Commission called on the university to conduct a proper audit of its lab, which has been responsible for nearly two dozen wrongful DUI convictions.
Labor unions' influence in LA mayor's race is harder to predict this year
As Mayor Karen Bass vies to keep her seat, she has a liberal opponent and a more complicated relationship with some labor leaders.
20th Annual Women in Medicine and Science Research Day
The 20th annual Women in Medicine & Science Research Day on March 11 offered opportunities for community-building, networking, mentoring and collaboration.
Meet The Small Business Claiming To Have Cracked AI Software Testing
Sauce Labs says its approach to testing, based on business intent, can help enterprises break the logjam caused by the need for quality assurance in software development
Khan says Labour should rejoin EU customs union and single market this parliament
London mayor also says his party should make clear manifesto commitment on full membership in next parliament
Google Shakes Up Its Browser Agent Team Amid OpenClaw Craze
As Silicon Valley obsesses over a new wave of AI coding agents, Google and other AI labs are shifting their bets.
Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
Sandhills Calving System continues to protect calf health, ranch profitability
Twenty-five years ago, a collaboration between a Sandhills ranch family, a rural veterinarian and Husker researchers led to a management innovation that transformed how cattle producers prevent calf scours. Known today as the Sandhills Calving System, the approach has become one of the most widely recommended strategies for preventing neonatal calf diarrhea.
HHS announces first Rural Health Transformation Program funding opportunity to strengthen rural health care workforce | Health and Human Services North Dakota
North Dakota Health and Human Services (HHS) today announced the first Rural Health Transformation Program funding opportunity is now available to support the retention of health care professionals in North Dakota’s 37 critical access hospitals and their owned and operated clinics. The deadline to apply is 5 p.m. CT April 30.
Keweenaw Bay Ojibwa Community College students engage with science in new laboratory
Previously, students did not have a lab and had to take courses digitally.
Dutchess County and CSEA workers reach 4-year labor agreement
The agreement reached Wednesday is retroactive to Jan. 1, 2025.
Chicago Booth Partners with MasterClass on AI-Era Business Education
MasterClass Executive, developed in collaboration with OpenAI, brings a new business school experience to working professionals.
Shia LaBeouf causes disturbance in hotel lobby while wearing only his underwear after New Orleans arrest
Shia LaBeouf was filmed causing a disturbance in a hotel lobby in Rome after he was arrested in New Orleans: 'Give me a f---ing match.'
Youth Mental Health Action Lab: Leveraging First Spouses to Drive Change
First Spouses and state policy teams from across the country convened in Asheville, North Carolina on March 9–10 for NGA’s Youth Mental Health Action Lab, marking the kickoff of NGA’s 2026 Youth Mental Health initiative. Building on work NGA has supported since 2022, sessions explored the landscape of the youth mental health crisis, emerging best […]
Sanford Sports launches in Black Hills region
Sanford Sports, the modern athletics arm of Sanford Health, is now available to athletes in the Black Hills region of South Dakota.
Federal Reserve holds interest rates steady
Federal Reserve policymakers chose to leave interest rates unchanged at their March meeting amid a softening labor market and uncertainty over the economic impact of the Iran war.
Small Business Focus: Does AI keep you up at night?
Artificial intelligence is quickly becoming one of the most valuable tools available to small businesses and entrepreneurs — and BizLaunch is bringing that opportunity to the local business community with an upcoming in‑person workshop, “AI Advantage: Creating Winning Proposals With Smart Tools.” Led by the expert consultants at Revby, the program will explore how AI
Federal investment fuels new labs for coastal science and restoration
The two are part of the Institute of Environment’s efforts to expand research on the Everglades, Biscayne Bay and other South Florida’s coastal ecosystems. The project received $11.5 million in funds.
Apple CEO Tim Cook doubles down on policy over politics while aligning with Trump’s manufacturing push
Apple CEO Tim Cook rejects any political labels while defending his close ties to the Trump administration amid criticism over his "Melania" documentary attendance.
Gavin Adcock ‘The Day I Hang It Up Tour’ includes two Alabama shows: Act fast and secure your tickets
Fans can catch Adcock at popular venues in Orange Beach and Birmingham later this year.
Marquee Sports Network now available on Hulu + Live TV
The regional sports network's direct-to-consumer service is now also available for purchase on Prime Video.
Republicans hope to label Democrats as party of election fraud in voter ID debate
Democrats say the bill could disenfranchise millions of Americans including women, minorities and low-income Americans.
Doug Jones calls out Tuberville’s ‘dog whistle rhetoric for political gain’
“We must make it clear that no American, or Alabamian, is our ‘enemy,’” Jones said.
March Madness 2026 bracket: NCAA Tournament picks, predictions from seasoned college basketball model
SportsLine's model has nailed 25 first-round upsets by double-digit seeds and revealed its optimal NCAA Tournament bracket 2026
Proposed Ohio-Israel partnership draws business group support, activist criticism
COLUMBUS, Ohio (WCMH) — The Ohio Senate is considering legislation that would create a formal partnership between the state and Israel aimed at expanding trade, investment and research collaboration. ...
Child vaccination rate drops sharply in Michigan under RFK Jr's influence
Vaccination rates among young children in Michigan dropped sharply during the first year of the Trump administration, a Reuters analysis of state data shows, providing an early indication of how vaccine-skeptic Health Secretary Robert F. Kennedy Jr. is influencing immunization practices in the United States.
NVIDIA CEO defends DLSS 5 as gamers label it an 'AI slop filter'
Memes about the AI rendering model quickly spread after it was unveiled on Monday.
Intel Precompiled Shaders Accelerate Game Load Times By Up To 3x On Arc GPUs, Now Available & Supported In 13 Games
Intel Arc GPUs can finally enable Precompiled Shaders for faster loading times that are supported in 13 games at launch.
A dietitian and doctor review RFK Jr's new food pyramid
The new food pyramid was released earlier this year. It emphasizes protein, full-fat dairy and what Health and Human Services Secretary Robert F. Kennedy Jr. calls “healthy fats.” These guidelines influence the standards for school lunches, food labeling and programs like SNAP. Today on the show, Short Wave co-host Emily Kwong chats with registered dietitian nutritionist Shana Spence, and Dr. Sarah Kim, a diabetes specialist, about the new guidelines. Plus, NPR’s Reflect America fellow Kadin Mills unpacks how the new food pyramid could change school lunch trays. Check out more of Kadin’s coverage about the changes in dietary guidelines.Interested in more health science? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Labrinth Slams Music Industry for Turning ‘Gods Noise Into Business Transactions’
The composer behind Euphoria‘s soundtrack previously denounced the HBO show in a cryptic social media post
Scientists from Northwestern, other institutions cool down chamber for groundbreaking dark matter search
An international team involving Northwestern University announced Tuesday that it has reached a major milestone in its quest to detect dark matter.
US lawmakers Murphy, Casar push legislation to regulate prediction markets
The legislation aims to prevent bets made based on insider knowledge of wars, economic policy and controllable events.
Former state health commissioner appointed to role supporting Minnesota hospitals
Former Minnesota Department of Health Commissioner Jan Malcolm will collaborate with leaders from hospitals and health systems across the state to tackle financial challenges to support hospitals and ensure access to care statewide.
Penguins Foundation and UPMC Western Behavioral Health to Host 3rd Annual Mental Health and Student-Athletes Symposium on April 15
On April 15, 2026, the Pittsburgh Penguins Foundation in collaboration with UPMC Western Behavioral Health, UPMC Sports Medicine, and the Citrone Thirty-Three Foundation, will host its 3rd Annual Mental Health and Student-Athletes: Managing the Invisible Injury—a free educational symposium at PPG Paints Arena. The event will bring together coaches, athletic
Beats and Nike team up on special edition Powerbeats Pro 2
Beats and Nike are teaming up for their first-ever hardware collaboration. The new “Powerbeats Pro 2 – Nike Special Edition”...
Environmental science student earns prestigious internship at Germany’s Freiburg University
Nelly Koz has always made an impact in her community through her love of the outdoors. Now, she’ll have a chance to make an impact on a global level. The environmental science major recently accepted a lucrative internship at Freiburg University in Germany, where she will help with data collection and recording observations on a section of the Black Forest that serves as a living laboratory.
Alabama's Aden Holloway arrested after authorities allegedly found over a pound of marijuana at residence, expected to miss NCAA tournament
Hilary Duff defends her mother Susan after Frankie Muniz called her a 'super intense’ stage mom during the 'Lizzie McGuire' days
Hilary Duff defends mother Susan after Frankie Muniz labeled her ‘super intense’ stage mom: ‘I was never pushed into acting.'