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Prep talk: Mt. SAC Relays to feature Servite, Rosary relay teams
The Mt. SAC Relays offer another opportunity to feature the best athletes in high school track and field.
Who is the best athlete in U.S. history? USA TODAY launches '250 for 250'
Who is the GOAT of U.S. sports history? USA TODAY's "250 for 250" project will give readers a chance to weigh in.
Some health AI tools worsen admin burdens, but backers still see promise
Backers still see promise.
Steph Curry is testing Fitbit's screenless Whoop competitor
The NBA's greatest shooter has been not-so-subtly showing off the potential Whoop killer.
How are Giants fans feeling about the season thus far?
The Giants are back on the road this weekend. So let’s check in with Giants fans to see how they’re feeling about the season thus far.
26 Cheap And Easy Home Upgrades And Projects To Do
"It was supposed to be a temporary solution until I saved some money — but I like it so much I still haven't changed it three years later."
2026 NFL Draft final combined big board: Buckeyes defender is No. 1, with Fernando Mendoza right behind him and Rueben Bain Jr. top-5
New York Islanders sign star Wisconsin hockey forward
21-year old Wisconsin Badgers forward Quinn Finley has signed a two-year, entry-level contract with the New York Islanders.
Shohei Ohtani strikes out 10, Dodgers win in first pitcher-only game in 5 years
Shohei Ohtani to take mound as pitcher only for first time in 5 years
They Want to Drop a Bomb in Iran in Honor of My Father, Peter Rodrick
My father died while serving as a squadron commander and Navy pilot. When a request was made to attack Iran in his honor, I decided to take a road trip
Orioles manager Craig Albernaz has broken jaw, 7 facial fractures after getting hit by Jeremiah Jackson line drive
Impeachment of Lexington judge ‘not about politics,’ former lawmaker says
Killian Timoney filed the impeachment petition against Judge Julie Muth Goodman in January.
Brenda Alexander talks the latest in entertainment headlines
Russel Simmons and Kimora Lee are back in the headlines. And reports of an Atlanta housewife with custody issues.
Microsoft Rejects Speculation It’s Axing Carbon Removal Business
Microsoft Corp., the world’s biggest investor in carbon removal projects, rejected speculation that it is abandoning its efforts to build out the technology.
Astros place shortstop Jeremy Peña, pitcher Tatsuya Imai on injured list amid 7-game losing streak
Leeds grab lead at Old Trafford inside five minutes 💥
Leeds United really couldn't have asked for a better start to Monday's match against Manchester United at Old Trafford. Seconds after kick off, the visitors almost went 1-0 up after Dominic Calvert-L...
Philippine President Marcos debunks health rumors with jumping jacks
Philippine President Marcos debunks health rumors with jumping jacks
Hawai‘i Might Just Slay Citizens United — And You Can Help
We have the authority — and the responsibility — to get rid of dark money.
Game 13 Game Day Thread – Texas Rangers @ Los Angeles Dodgers
Venturing to the storied UNIQLO Field in LA
Retro NYC video store marks booming first year in business – thanks to growing Gen-Z demand for VHS, DVDs
It’s been a blockbuster year for this Brooklyn shop! Night Owl Video, the Big Apple’s sole remaining video store, is ringing in its first year in business this weekend – and is already...
Pixel 11 Series to See Big Display Upgrade
Industry sources have confirmed that Google’s upcoming Pixel 11 series will utilize Samsung’s new M16 OLED panels. These are the same panels expected to be used by Apple for its... #Google #Pixel11
Beacon Health names Sarah Paturalski president of Dowagiac hospital
Beacon Health System has named Sarah Paturalski as president of Beacon Dowagiac, tapping a longtime nursing leader who most recently served as interim president
Entertainment: Don’t Miss The ‘Longest Continuously Running Beer Festival in the United States’
Plus: Doggy Day at Deer District and Spoof Fest in Bay View.
Conservative Activists Take Aim At Native Hawaiian Health Scholarship
A new lawsuit filed by a legal advocacy nonprofit says a 35-year-old federal scholarship program that brought Native Hawaiian doctors to the islands is unconstitutional.
Beloved pizza chain closes all locations after a half-century in business
It's bad news for fans of the chain.
After 39 years on air, Melinda Mayo turns the mic down to put health first
For 39 years Melinda Mayo has been a trusted voice in Arkansas, but recently that voice began to change.Melinda says, "Almost like when you're coming down with
Robbins mayor says village ‘open for business’ | ChicagoLIVE
Mayor Darren Bryant highlights new investments and development opportunities as the south suburban community looks to attract growth.
2026 NFL Mock Draft: Baltimore Ravens take tackle
With the 14th overall pick in the 2026 Bleeding Green Nation community mock draft, Baltimore Ravens GM 215T1LL1D1e selects ...
Dream acquire two-time All-Star Angel Reese in trade with Sky
Broncos' order of picks in 2026 NFL draft
Take a look at the Broncos' order of picks in the 2026 NFL draft.
Lincoln Heights community building brings more opportunities for businesses, organizations
The Village of Lincoln Heights is helping bring businesses and organizations together under one roof.
Forget the workarounds — get real Office apps for your Mac for just $50
Pay once, use forever.
Can Hawaiʻi Deliver All Of America From Citizens United?
A state Senate bill proposes a novel approach that one legal expert says would make the controversial national campaign finance law irrelevant in the islands.
Scientists found a protein that drives brain aging — and how to stop it
Scientists have uncovered a powerful new clue in the mystery of brain aging: a single protein called FTL1. In aging mice, higher levels of this protein weakened connections between brain cells and led to memory decline. But when researchers reduced FTL1, something remarkable happened — the brain began to recover, rebuilding lost connections and restoring memory performance.
Cooper Flagg becomes youngest player in NBA history to post 50-point game
A 19-year-old just dropped 51 points in a game.
Maui Mental Health Providers Face Stress And Uncertainty About State Jobs
Staff at a state-run clinic serving wildfire survivors in Hawai‘i have waited months for permanent jobs. Instead, they got another temporary contract.
The hero of the day
The earliest bits of concrete NC State sports memories I have involve Torry Holt and Justin Gainey—1997 felt a little transformative for both sports at the time. Torry helped the football team pull a huge upset in a (nonconference) game at Syracuse to open the ‘97 season; in March of that year, Gainey played every […]
Restroom Revolutions: A history of bathroom politics presentation April 11
Edmonds SnoKing AAUW is hosting Sara Chatfield, associate professor in gender and women’s studies, for a thought-provoking Zoom presentation Saturday, April 11 on how America’s bathrooms have long reflected battles […]
Publicis sharpens sports marketing focus with 160over90 acquisition
Publicis CEO Arthur Sadoun described sports as the firm’s “next big bet” as it tries to bring cohesion to an increasingly valuable but fragmented market.
'A considerable gamble' at 'a fragile moment'
Only Tottenham would respond to the current bin fire at the club by turning to a famously incendiary manager to put out the flames. After tens of thousands of supporters lined the streets in an act of unity, the Tottenham board split the fanbase by appointing Roberto de Zerbi. The Italian, known for his high-pressing, attacking football, arrives with a reputation that has already prompted concern from supporter groups and the Tottenham Hotspur Supporters' Trust.
‘Knife fight’ politics take a mental health toll on SF leaders
After Supervisor Jackie Fielder’s hospitalization, officials speak out about pressure, stigma, and survival.
‘Knife fight’ politics take a mental health toll on SF leaders
After Supervisor Jackie Fielder’s hospitalization, officials speak out about pressure, stigma, and survival.
Why Do Animals Glow? The Science of Bioluminescence
From ocean depths to forests, some animals glow — and it’s key to their survival.
Vertex AI Vulnerability Exposes Google Cloud Data and Private Artifacts
Unit 42 found excessive P4SA permissions in Vertex AI, enabling credential theft and cloud data exposure, increasing breach risk.
Police: Woman hospitalized with laceration after altercation in Lauderhill
A woman was hospitalized Monday morning following an altercation with another woman and girl in Lauderhill, police confirmed.
NCAA tournament takeaways: UConn reaches Final Four on wild game winner over Duke; UConn and UCLA women each pull away in Elite Eight
March Madness Final Four schedule, how to watch: Keep up with UConn-Illinois, Michigan-Arizona in Indianapolis
'A muzzle on elected officials': NDAs 'cloak' Louisiana's biggest business developments
Louisiana officials signed non-disclosure agreements as Amazon's $12 billion data centers unfolded in secret.
Bucks convert Pete Nance to standard deal
Bucks convert Pete Nance to standard deal
Long fingernails vs. touchscreens: This nail polish could help
Undergraduate's prototype conductive nail polish could turn long fingernails into touchscreen styluses.
iPhone Air Said to Be Roughly Twice as Popular as iPhone 16 Plus
While it certainly has its critics, the iPhone Air appears to have validated Apple's decision to retire the iPhone Plus, if new results from an independent analysis are anything to go by. Crowdsourced Speedtest data published by Ookla suggests the iPhone Air captured 6.8 percent of iPhone 17 generation samples in the U.S. during the fourth quarter of 2025, up from the 2.9 percent share the iPhone 16 Plus managed in the same launch window a year earlier.
STC HVACR student turns childhood lessons into vision for future business
Currently pursuing an associate degree in Heating, Ventilation, AC and Refrigeration (HVACR) at South Texas College, Cesar Bernal III said he was just 12 years old when he began watching his father turn determination and hard work into a small but thriving air-conditioning business in Weslaco.
3 things to know about new 49ers punter Corliss Waitman
The San Francisco 49ers are replacing Thomas Morstead with Corliss Waitman. Let's get to know the team's new punter before he boots his first ball.
Locally-based behavioral health group to open first Louisville office
The location will provide individual, couples and family therapy.
Educational Service Center awarded Teach Computer Science 2.0 Grant
The Educational Service Center of the Western Reserve has been awarded $584,614 through the Ohio Teach Computer Science 2.0 State Grant, a competitive initiative funded by the Ohio Department of Higher Education. As part of an $8 million…
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The Times' final top 25 high school boys' basketball rankings
Sierra Canyon, the state Open Division champion, finishes No. 1 in The Times' final 2025-26 high school boys' basketball rankings.
Southland girls' basketball final rankings for 2025-26 seaosn
A look at the top 20 high school girls' basketball teams in the Southland, led by Open Division state champion Ontario Christian.
NCAA tournament takeaways, Day 3: Big Ten reigns supreme, 'Cinderella' Texas and an extra edge for Houston
Black Family Wellness Expo brings people together for day of health education
The Black Family Wellness Expo returned to Roselawn Saturday.
Reddit is weighing identity verification methods to combat its bot problem
Steve Huffman, Reddit's CEO, said that using biometrics is the "most lightweight way" to verify that it's a human.
Mira Costa boys' volleyball defeats rival Loyola in thriller
Mira Costa, the top-ranked boys' volleyball team in the nation, defeats No. 2 Loyola in five sets behind Mateo Fuerbringer's 37-kill effort.
DarkSword iOS Exploit Kit Uses 6 Flaws, 3 Zero-Days for Full Device Takeover
DarkSword exploit targets iOS 18.4–18.7 using 6 flaws and 3 zero-days, enabling rapid data theft from iPhones across multiple countries.
Tim Cook on iPhone's Future: 'There's So Much Left That We Can Do'
In an interview with Nikias Molina at New York's Grand Central Terminal last week, Apple's CEO Tim Cook briefly commented on the future of the iPhone. "There's so much left that we can do with the iPhone," said Cook. "I think it's going to continue to be the center of people's digital lives".
Spigen's New AirPods Pro 3 Case Is Modeled After the Original Macintosh Mouse
Accessory maker Spigen this week expanded its lineup of case options that are designed to look like vintage Apple Macs. The clever new Classic LS AirPods Pro 3 Case resembles a the iconic Apple Macintosh mouse, so it goes well with Spigen's Mac-style iPhone cases. Priced at $25 from Amazon, the case features the stone color that was used for the Classic Macintosh, along with a gray mouse button.
Sky 5 flies over large police presence at North Carolina School of Science and Mathematics in Durham
Sky 5 flew over the North Carolina School of Science and Mathematics in Durham, where there is a large police presence. This video does not have sound.
Scientists say marijuana doesn’t ease anxiety or other mental health conditions
Using medical or recreational marijuana to ease symptoms of numerous mental health conditions doesn’t work, according to new analyses
Oppo’s Find N6 might be the foldable of your dreams
Just like a dream, the Find N6 it may be forever out of reach.
March Madness bracket: 4 dark-horse candidates capable of making a deep NCAA tournament run
UC Health opens $10M center billed as world's most advanced
The C-STARS facility will train 300 Air Force medical teams annually. UC Health has trained more than 5,000 Air Force medical professionals since 2002.
Public health alert issued for frozen meat products sold at popular retailer
The Food Safety and Inspection Service issued a public health alert for frozen ready-to-eat meat products sold at a popular retailer.
Pols & Politics: Campbell, DiZoglio to share the stage at St. Patrick’s Day breakfast amid audit battle
Attorney General Andrea Campbell and state Auditor Diana DIZoglio will be sharing the stage, and perhaps some obligated playful banter, during the annual St. Patrick’s Day breakfast on Sunday.
Christ Hospital Health Network expands women's care with new Greater Cincinnati site
The 4,551-square-foot facility is scheduled to begin seeing patients March 16.
Linux Finally Catches Up to Windows with a Game-Changing Performance Feature
For years, the Linux kernel’s scheduler has been world‑class at balancing loads, yet it missed a crucial, cache‑aware instinct. In modern multi‑core systems, that gap can turn into measurable latency, especially when threads bounce between cores that don’t share the same cache. A new upstream feature, often called Cache Aware Scheduling, is now set to change that equation. A cache‑savvy scheduler arrives At the heart of any OS, the scheduler decides which thread runs where and for how long. In modern CPUs, small private caches (L1 and L2) sit beside each core, while a larger Last Level Cache (LLC, typically L3) is shared among groups of cores. When a task migrates across LLC boundaries, its warm data may vanish from the cache, forcing slower trips to main memory. Cache Aware Scheduling keeps related tasks close to their shared LLC, reducing destructive migrations. By respecting cache topology, the kernel minimizes cold‑start penalties and preserves locality that many workloads desperately need. The result is less thrashing, fewer memory stalls, and more consistent throughput. "Keep tasks close to their data, and the system will keep performance close to its peak." Why this narrows the Windows gap Windows has long leaned on topology‑aware, cache‑sensitive heuristics, especially since the Windows 10 era. That advantage helped Microsoft handle hybrid designs with P‑cores and E‑cores, plus complex cluster and NUMA layouts. With cache awareness integrated upstream, Linux brings parity to this vital dimension, without sacrificing its trademark flexibility. The Linux approach remains deeply configurable, reflecting the ecosystem’s breadth across servers, desktops, and embedded devices. It layers atop existing NUMA‑balancing and energy‑aware logic, refining placement rather than reinventing the wheel. Crucially, it aligns scheduling with the hardware’s real shape, not just with abstract CPU counts. Real‑world gains and who benefits Early tests on Intel Sapphire Rapids platforms point to gains in the 30–45% range for select workloads. Those wins appear in cache‑sensitive tasks like in‑memory analytics, high‑thread compilation, and microservices with tight working‑sets. Games and latency‑bound engines can also feel steadier frame‑times, especially when threads share hot assets. The benefits extend to AMD’s 3D V‑Cache parts, where keeping threads near enlarged cache slices prevents needless misses. Hybrid x86 designs with performance and efficiency cores further profit when cache and core roles are scheduled in concert. Even handhelds running SteamOS can squeeze more out of limited power, translating cache locality into smoother play. Key advantages include: Lower end‑to‑end latency Fewer expensive misses to RAM Better multi‑socket and NUMA behavior Improved energy efficiency More predictable QoS under mixed loads Stronger scaling on dense servers Caveats, tuning, and rollout No scheduler change is purely free, and trade‑offs still exist. Favoring locality can reduce cross‑cluster balance if limits are set too tight. Likewise, fairness and utilization must remain healthy, especially under heterogeneous, bursty workloads. Linux’s implementation is designed to be measured and tunable, not a blunt instrument. It cooperates with energy‑aware scheduling for mobile efficiency, and with NUMA‑balancers on big iron. Expect architecture‑specific refinements as vendors surface richer topology hints and cache‑sharing maps. Upstream integration has begun, with broad distribution adoption likely over the next cycles. Many users will encounter the change through standard kernel updates in 2025–2026, depending on distro cadence. Server‑class kernels may enable or tune it sooner for targeted fleets where cache locality is money in the bank. How to think about performance impact Cache Aware Scheduling amplifies gains when your workload is both CPU‑bound and cache‑sensitive. Think tight inner loops, hot code paths, and datasets that fit snugly in shared LLC. It’s less dramatic for I/O‑bound services or memory‑hungry tasks that blow past cache capacity. Still, even modest locality improvements often translate into smoother tail‑latency, which is where user experience and SLAs typically break. Developers can further help by pinning related threads, batching work, and aligning data to reduce cross‑cluster chatter. The scheduler’s new awareness works best when applications expose good hints. The bottom line By understanding and honoring cache topology, Linux removes a subtle yet costly bottleneck. The kernel’s smarter placement keeps hot data hot and work near where it belongs. That narrows a long‑standing gap with Windows, while preserving the openness and tunability Linux champions. For gamers, creators, and operators, the payoff is practical: more consistent frames, faster builds, and snappier services. For the ecosystem, it’s another step toward hardware‑savvy scheduling that turns transistor complexity into real‑world speed. And for Linux itself, it’s a timely upgrade that matches today’s silicon with tomorrow’s expectations.
Millions of Americans are skipping meals or cutting back on utilities to afford health care
“I never thought I’d be living like this,” said Sheila Nesbit, a retired librarian.
No. 17 Boston College blanks Maine in Hockey East quarterfinals
The Boston College men's hockey team bounced back from its regular-season finale loss with an impressive postseason win on Friday.
WATCH: Vance speaks in new North Carolina district seen as competitive for GOP in 2026
Vice President JD Vance delivered remarks on the economy Friday in Rocky Mount, North Carolina, in a newly redrawn congressional district seen as competitive for the Republican Party in the November midterms.
Former Spartan Connor Heyward reportedly signs with Las Vegas Raiders
Another Spartan is heading to Sin City to continue his NFL career
Breaking Down Meg Ryan’s Health Issues: Why Does She Limp?
The actress will be making high-profile appearance to honor Rob Reiner at the Oscars.
Primary Care Must Be Protected As Hawaiʻi’s Health System Evolves
If we are serious about long-term health care cost control and outcomes, we must shift more resources to primary care.
Beyond The Burn Zone: Maui Wildfires Cause Widespread Mental Health Issues
New research shows housing displacement and income loss were central drivers of psychological harm.
Old NASA science satellite plunges back to Earth
An old NASA science satellite plunged uncontrolled from orbit and reentered over the Pacific on Wednesday. The U.S. Space Force said the Van Allen Probe A came in west of the Galapagos Islands. NASA...
NFL news, free agency updates: Ravens, Trey Hendrickson reportedly agree to 4-year, $112M contract after 'backing out' of Maxx Crosby trade with Raiders; Daniel Jones, Colts reach 2-year extension
Squid Game: Unleashed dev Boss Fight Entertainment relaunches as indie studio Bossfight
Boss Fight Entertainment’s original founders have relaunched as an independent studio under a similar name. Now called Bossfight, the studio is operat...
NFL news, free agency updates: Ravens reportedly agree to 4-year, $112M contract with Trey Hendrickson after 'backing out' of Maxx Crosby trade with Raiders
Palisades comes up just short against Bakersfield Christian
Jack Levey’s three-pointer at the buzzer was off target and Palisades lost to Bakersfield Christian in the Southern California Regional Division II final.
Girls basketball: Ontario Christian to play Sage Hill in regional final
Ontario Christian defeats Etiwanda and will play Sage Hill in the girls' basketball Southern California regional final after the Lightning's upset over Sierra Canyon.
Police: Man arrested after trespassing at Wilton Manors business, loitering at private residence
A 53-year-old man was arrested Wednesday after he violated a no trespass order at a bar in Wilton Manors, authorities said.
15 Foods Highest in Vitamin B12 for Energy and Brain Health
Foods like crab, trout, salmon, and clams are high in vitamin B12. These and other B12-rich foods can offer health benefits.
Artificial Intelligence in Military Medicine: USU Leaders Highlight the Future of Health Education
Panelists at the AMSUS annual meeting discussed how the responsible integration of artificial intelligence will shape the next generation of...
NC-11 race could depend on independent votes, national politics: former NC Rep. Shuler
The last Democrat to hold the seat of NC-11 says the outcome of November's general election could hinge on independent voters and national political winds.
Republicans Cornyn and Paxton advance to Texas Senate runoff
Four-term Sen. John Cornyn and his allies spent nearly $70 million to survive the first round of the party’s nomination fight on Tuesday. He was slightly ahead of conservative firebrand Ken Paxton, the state attorney general, with more votes still being counted on Wednesday.