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State AG sees rural care in action at Sanford Bemidji
Attorney General Keith Ellison toured Sanford Health in Bemidji to learn about efforts to expand healthcare access across northern Minnesota.
GOP gubernatorial candidate pitches plan to lower property taxes
Charles, an attorney and former federal official, said he will also work with the federal government to increase funding for things like substance use disorder treatment.
Broome County Mental Health talks BC SAFE and Suicide Prevention
Heidi Mikeska and Brittany Riso from the Broome County Mental Health Department came on to talk about the results of Chalk the Walk and Suicide Prevention Month.
Giants' Marvin Harrison Jr. Rumors Make Sense Under One Condition
Could the New York Giants actually trade for wide receiver Marvin Harrison Jr.?
New local effort begins to help small businesses grow
A new business has opened at Edison Mall in Fort Myers to help smaller enterprises grow. It's called the Business Growth Gallery.
Why Jon Favreau ‘said yes’ to directing ‘Young Sheldon’ pilot (exclusive)
‘Iron Man’ director Jon Favreau explains in Entertainment Weekly’s exclusive ‘Young Sheldon’ excerpt why he ‘said yes’ to directing the show’s 2017 pilot episode.
AMO Pharma in Collaboration with Population Health Research Institute (PHRI) and Venca Research Inc. Announces FDA Advice on Potential Phase 3 Development Path for AMO-02 in Treatment of Arrhythmogenic Cardiomyopathy (ACM)
/PRNewswire/ -- AMO Pharma Limited ("AMO Pharma"), a privately held clinical-stage specialty biopharmaceutical company focusing on rare genetic disorders with...
Nick Lachey kicked off fall at Kings Island, says park's 'still got it'
A famous Cincinnati native, who previously worked at Kings Island, stopped by the park to enjoy fall festivities.
Preteens, phones and a hidden health risk
A study found 70% of kids they followed owned a smartphone by age 12. The kids reported at least one symptom of an eating disorder by 14.
Manny's exit boosts McCoy in supervisor race
Three candidates remain in the battle to represent D8.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Former nursing supervisor back in court for Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court Wednesday, eight months after the woman was found dead outside the facility.
Lamar Jackson Injury Update: Ravens QB’s Week 5 Status Revealed
Lamar Jackson suffered an ankle injury in Week 4, and the two-time NFL MVP left the game in a walking boot. This is obviously worrisome news for Ravens fans across the globe, but it does not appear to be a serious issue. Originally entering the league as a first-round pick in the 2018 NFL Draft, …
HEALTH Yeah! Episode 36: Think Midwives Are Just for Birth? Think Again!
Learn what midwives really do as Stony Brook Midwives clear up common misconceptions and explain the benefits of midwife-led care.
Former nursing supervisor to face judge in Bickford Health Care death
A former nursing supervisor accused in the death of a 93-year-old Bickford Health Care resident is expected in court today, eight months after the woman was found dead outside the facility.
Congress Asset Management Co. Acquires New Holdings in Madison Square Garden Entertainment Corp. $MSGE
Congress Asset Management Co. bought a new stake in Madison Square Garden Entertainment Corp. (NYSE:MSGE - Free Report) during the third quarter, according to the company in its most recent Form 13F filing with the Securities & Exchange Commission. The fund bought 303,087 shares of the company's
Science investment plans put basic research at risk, critics say
Market-driven approach sparks caution among New Zealand researchers
Skydance now runs two of Hollywood’s legacy film studios. A look at the new company, by the numbers
David Ellison’s Paramount Skydance has completed its $81 billion acquisition of Warner Bros. Discovery, bringing two of Hollywood’s most storied legacy film studios under one mammoth media and entertainment conglomerate named Skydance. Now, Skydance must decide how to make the most out of a trove of entertainment assets, including the HBO Max and Paramount+ video streaming services, a film library that includes “Star Trek,” “Barbie,” “Top Gun,” “Harry Potter,” and “Superman,” and two major news organizations, CNN and CBS News. Here’s a look at the new company, by the numbers.
PTSD, Health-Related Social Needs Together Increase Cognitive Risks Significantly in Veterans
A recent study asked a question critically important to VHA clinicians: Are post-traumatic stress disorder (PTSD) and health-related social needs (HRSNs) associated with incident mild cognitive impairment, Alzheimer’s disease and Alzheimer’s disease-related dementias among U.S. veterans?
San Antonio tax preparing business owner sentenced to federal prison, ordered to pay $3.8 million
A San Antonio woman convicted of falsifying tax forms on behalf of her clients was sentenced to federal prison and ordered to pay more than $3.8 million dollars in restitution, the U.S. Department of Justice announced Tuesday.
Trump admin struggles to get answers from Russia on potential plague death
The Trump administration is struggling to get clear answers about the death of a Russian laboratory worker at an institute dedicated to studying the plague, amid days of stonewalling from Russian officials about the mysterious circumstances surrounding the episode.
Cartier Got Down to Business for the 20th Anniversary of the Women’s Initiative
Guests from across the arts, public health, philanthropy, and fashion gathered at the Morgan Library and Museum to celebrate the 20th anniversary of the Cartier Women’s Initiative: the maison’s fellowship for entrepreneurs focused on implementing social and environmental change.
David Ellison backs CNN’s Trump lawsuit, pledges editorial independence
CNN’s new owner, David Ellison, says he supports CNN’s legal action against the Trump administration over White House access, and will not interfere in the news organization’s coverage.
TROY College of Science and Engineering students create Dean's Student Advisory Council
Students within the College of Science and Engineering now have the opportunity to make a lasting impact on college initiatives, improvements and student experiences thanks to the creation of the Dean’s Student Advisory Council.
Nobel Prize in physics awarded to Francis Halzen for groundbreaking neutrino research
The Royal Swedish Academy of Sciences has awarded the 2026 Nobel Prize in physics to Francis Halzen of the University of Wisconsin–Madison.
Tyra Banks explains why she wasn’t on ‘Project Runway’ after on-air clash with Law Roach
Tyra Banks explained why wasn’t on ‘Project Runway’ after her on-air clash with Law Roach in episode 5: ‘People lost their damn minds,’ Banks tells EW.
We studied American Jews’ mental health after Oct. 7. They’re not OK.
Research showed invalidation in ways that were painful, isolating and sometimes startling, writes a co-founder of The Jewish Community Mental Health Initiative.
VistaJet receives luxury and business awards
VistaJet was commended by a luxury magazine, while also receiving an award for brand image and service at a Chinese finance summit.
US appeals court weighs block on Kennedy's vaccine panel appointments
A lawyer for the Trump administration told a federal appeals court on Tuesday that a judge had improperly hamstrung an influential vaccine advisory panel by blocking Health Secretary Robert F. Kennedy Jr.'s handpicked appointees from serving on it.
Paramount-Warner Bros. Discovery merger closes, creates combined company Skydance
David Ellison, CEO of Paramount Skydance, speaks during CinemaCon 2026 on April 16, 2026, in Las Vegas, Nevada. (David Becker/Getty Images for CinemaCon)
Health Alert – U.S. Embassy Moscow, Russia (October 6, 2026)
Health Alert – U.S. Embassy Moscow, Russia (October 5, 2026) Location: Irkutsk, Russia Event: The U.S. Embassy is aware of press reports from the Irkutsk region of suspected pneumonic plague resulting in the death of an individual and of associated quarantine measures in, and closures of, hospitals in Irkutsk. We continue to track the situation closely. The U.S. government has limited ability to help U.S. citizens in Russia, especially outside of Moscow. U.S. government personnel may face additional restrictions for personal and official travel to specific regions due to health and security concerns. The State Department’s Level 4 Travel Advisory (Do Not Travel) for Russia remains in place and states U.S. citizens currently in Russia should depart immediately. U.S. citizens planning travel to Russia are again strongly advised not to travel to Russia due to risk of wrongful detention and security concerns. Actions to Take: S. citizens in the area should follow the guidance of local health authorities, avoid affected facilities, and seek medical care promptly if they develop fever or respiratory symptoms. Visit the CDC Page on Plague for additional information about the disease. Visit the CDC Travelers’ Health Page for Russia for country-specific health updates. Monitor your health for 14 days following travel if you traveled to an area experiencing the outbreak. Review the S. Embassy country page for general health information. Refer to the Embassy’s list of medical providers. Check with your travel insurance provider about medical evacuation options should you fall ill while overseas. Have a plan to depart in an emergency that does not depend on U.S. government help. Monitor local media for updates. Be prepared to adjust your plans. Enroll in the Smart Traveler Enrollment Program(STEP) to receive health and security updates. Assistance: U.S. Embassy Moscow, Russia +7 495 728-5577 MoscowACS@state.gov U.S. Embassy Moscow web page State Department – Consular Affairs (+001) 888-407-4747 or (+001) 202-501-4444 Russia Country Information Follow us on Facebook and Twitter State Department – Consular Affairs 1-888-407-4747 or 1-202-501-4444
BROWARD HEALTH : An Emergency Physician Discusses Dengue - Florida Hospital News and Healthcare Report
Dr. Craig Harrison, an emergency physician at Broward Health Medical Center, discusses how to prevent and treat dengue, who is most at risk, and when it is time to go […]
DOL renews charter for OSHA advisory committee
Eight of the 12-member committee’s seats are vacant, and the terms of the remaining four members are set to expire in January.
How Thomas Tuchel 'surprised' Jordan Pickford after breaking England record
Jordan Pickford playing for England and Thomas Tuchel looking concentrated
Charlie’s Beat: A Passion for Great Produce
The backbone of any Farmer’s Market are the purveyors of the raw products. The produce, fruit and vegetables, the meat, the honey, the herbs, and sometimes, because life requires beauty,
New on DVD: Get ready to mingle with 'DTF St. Louis'
Last month's Emmy winner for best limited series tops the DVD releases for the week of Oct. 13. "DTF St. Louis": HBO's seven-episode drama stars Jason Bateman as TV weatherman
Michael Douglas recalls conversations with Rob Reiner about having sons with ‘serious drug issues’
The “Basic Instinct” star’s son Cameron Douglas previously served a seven-year sentence in federal prison for drug possession.
Michael Douglas recalls conversations with Rob Reiner about having sons with ‘serious drug issues’
In his new memoir, Michael Douglas recalled conversations with Rob Reiner about having sons with ‘serious drug issues.’ Douglas’ son Cameron previously served a seven-year prison sentence for drug possession. Reiner’s son Nick wrote a semi-autobiographical film about his addiction.
Jesse Metcalfe makes rare comment on rumored “Desperate Housewives ”drama: ‘Wasn’t really aware’
The actor played John Rowland on 31 episodes of the ABC series.
What Nathan Gallagher said in final 'Below Deck' episode before arrest
"Below Deck Mediterranean" cast member Nathan Gallagher talked about his young family's future and overcoming challenges in his final episode before he was arrested and convicted on domestic violence-
LOCALIZE IT: As coding boom fades, computer science grads focus on AI skills in choppy job market
Computer science graduates face hiring challenges; artificial intelligence demand is shifting recruitment toward seniors
Tracy Brabin rules out business class flight for India trip
West Yorkshire's mayor answers questions about a trade mission to India and early prisoner release.
Scientist who hunts mysterious ghost particles in the Antarctic ice wins Nobel Prize for physics
Francis Halzen said it was predicted that he would win the prize, but the announcement still made him feel “strange.” The 82-year-old scientist is affiliated with the University of Wisconsin–Madison in the U.S.
Brazil: Lessons from a Disaster
By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.
Archbishop Golka to Celebrate 40 Days for Life Mass at Marisol Health
At the heart of the Church’s defense of life is a simple but powerful response: prayer. This October, Catholics across the Archdiocese of Denver are invited to come together in that prayer as Archbishop James R. Golka celebrates a special 40 Days for Life Mass at Marisol Health.The Mass will be celebrated on Friday, October 23, at 2:00 p.m. in the garden at Marisol Health, 2894 Olive Street in Denver. Together, the faithful will give thanks to God for the precious gift of life and pray for mothe
“Boy Meets World” star Matthew Lawrence recalls ‘dysfunction’ on “Girl Meets World ”set: ‘It was very weird’
Lawrence spoke to EW about reprising the role of Jack on a 2015 episode of the Disney Channel spinoff.
‘Adventure Time’ creatives break down its most haunting episode
Talk about a pillow fright! ‘Adventure Time’ writers and storyboard artists talk about how they created one of the cartoon’s most haunting episodes ever, ‘Puhoy!’
Politics & Power: From cyberattacks to job losses, what AI means for security & livelihoods worldwide
Nick Allard, dean of the Jacksonville University College of Law, joins News4JAX anchor Bruce Hamilton on this week’s episode of “Politics & Power” to discuss the double-edged sword of AI as both threat and solution and what world leaders must do now.
Beach advisory issued in Miami-Dade for elevated bacteria levels
The Florida Department of Health issued a health advisory for a Key Biscayne beach due to elevated levels of bacteria in nearby waters.
Napo Pharmaceuticals, a Jaguar Health Family Company, Sponsoring Intestinal Failure Panel Discussion at Pediatric Gastroenterology Conference in Abu Dhabi
Participants in the panel discussion include Dr. Christos Tzivinikos, and Pravin Chaturvedi, PhD, Napo's and Jaguar's Chief Scientific Officer and Chair of the Scientific Advisory Board.
Lamar Jackson Injury Update: Ravens QB Leaves Game In Boot
Lamar Jackson suffered an ankle injury in Week 4, and the two-time NFL MVP left the game in a walking boot. This is obviously worrisome news for Ravens fans across the globe, but it does not appear to be a serious issue. Originally entering the league as a first-round pick in the 2018 NFL Draft, …
Ubisoft Will Reportedly Try Relaunching Watch Dogs: Legion With a Director's Cut
Ubisoft will attempt to relaunch Watch Dogs: Legion next year via a revamped Director's Cut, it's been reported.
Francis Halzen wins Nobel Prize in physics for work on high-energy neutrinos from space
The 82-year-old scientist, originally from Belgium, is affiliated with the University of Wisconsin–Madison. His research into capturing neutrinos at the South Pole dates back to the 1980s.
Podcast: Wizards Training Camp, Alex Sarr Update, Preseason Nears
On the latest episode of the DC Roundtable Podcast covering the Washington Wizards, we dive into the training camp storylines, update on Alex Sarr and what to watch in game one of the preseason
Netflix's 'East of Eden' cast explain 'poetic' final scene, 'Timshel' meaning
Spoiler alert! The following story contains major details about the "Timshel," the seventh and final episode of Netflix’s limited series “East of Eden” (now streaming).
Science-backed guidance for healthy screen time
We’re all aware – and wary – of doomscrolling. Lots of screen time can be bad for us. But what if that’s not always the case? We spoke with the author of a study that found a positive relationship between screen time and brain development in young people. This episode, we sort through what to actually worry about when it comes to screen time – and what guidelines already exist that can empower you and the kids in your life.Interested in learning more about how screen time affects your brain? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Science-backed guidance for healthy screen time
We’re all aware – and wary – of doomscrolling. Lots of screen time can be bad for us. But what if that’s not always the case? We spoke with the author of a study that found a positive relationship between screen time and brain development in young people. This episode, we sort through what to actually worry about when it comes to screen time – and what guidelines already exist that can empower you and the kids in your life.Interested in learning more about how screen time affects your brain? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Northern Essex’s McCarthy Joins New Small Business Advisory Council
Michael McCarthy, executive vice president and chief financial and operating officer at Northern Essex Community College, was recently appointed to the Massachusetts Small Business Development Center statewide Advisory Council, a new group of business, government, economic development and community leaders helping guide the future of small business support in the state. The Advisory Council was
Nuclear power and waste on Inside West Virginia Politics
CHARLESTON, W.Va. (WOWK) – On this week’s episode of Inside West Virginia Politics, our guests join Rick Johnson to discuss nuclear interest in West Virginia and the school aid formula. In Segment …
Two more Final Cut animations on Warhammer TV this week
Plus, new episodes of Loremasters, Tale of Four Gamers, and How We Roll.
The Harvard Crimson (@theharvardcrimson)
24 likes, 0 comments - theharvardcrimson on October 5, 2026: "Caroline B. Kennedy ’80 introduced the Institute of Politics’ 60th anniversary forum Thursday, marking her first known public appearance at the Institute since she resigned from its Senior Advisory Committee more than six years ago. Kennedy — the daughter of President John F. Kennedy ’40, to whom the IOP is dedicated – stepped down as the committee’s honorary chair in 2020 amid concerns over the IOP’s diminished independence, declining programming, and tensions with Harvard Kennedy School leadership. Full story linked in bio. 🖋: Jen L. Phan and Mirei S. Saneyoshi 📷: Grace E. Yoon".
DHS buys 2 more detention centers in California for $950 million
WASHINGTON — The Department of Homeland Security has purchased two immigrant detention facilities in Adelanto for $950 million, according to the private prison corporation that sold them. The sale by
We issued a Water Advisory for Thea Foss Waterway - Tacoma-Pierce County Health Department
Last revised Oct. 5, 2026 While the advisory is in effect, avoid contact with the water for 48 hours after it rains.
Fall Preview with Entertainment Correspondent Mike Marra
Airdate: October 5th, 2026 Leoni Township Update with Administrator Mike JesterOctober 5, 2026City Treasurer Hosting Town Hall Meeting SeriesOctober 5, 2026Tecumseh Appleumpkin Festival This WeekendOctober 5, 2026Fall Preview with Entertainment Correspondent Mike MarraOctober 5, 2026Disney’s Frozen Premieres Thursday at The SaukOctober 5, 2026Alison McGlynn & Lilly Hayworth, The Annex Collective SalonOctober 5, 2026John Spink, Nite…
Did New Science Board Just Shift BioCryst's (BCRX) Investment Narrative?
BioCryst Pharmaceuticals recently formed a seven-member Scientific Advisory Board made up of experienced rare disease and drug development leaders to guide its research, clinical plans and regulatory approach. The depth of this board, spanning big pharma R&D, AI driven drug discovery and rare disease commercialization, directly targets BioCryst’s execution risk as it builds a broader pipeline beyond its current portfolio. We will now examine how BioCryst Pharmaceuticals’ investment narrative...
How to Watch Celebrity Weakest Link Season 2, Episode 3
Watch Celebrity Weakest Link live with TV channel, start time and streaming info. Stream Season 2, Episode 3 on Fubo — no cable required, free trial.
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
Poor leaders can tank employees’ mental health (and the company); his business summit puts workplace culture
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NWA C-Suite: Alison Nation
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NWA C-Suite: Alison Nation
Nation’s extensive experience in communications and marketing leadership prepared her for the role at Visit Bentonville. Under her leadership, the organization’s digital engagement and visibility growth for the city have...
Mary McNamara: As David Ellison names his new empire Skydance, the message is clear: He owns Hollywood
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‘Primetime’: Is catching predators justice or just entertainment?
Rating: ★★★½ Starring Robert Pattinson, Skyler Gisondo, Merritt Wever Directed by Lance Oppenheim Rated R Release Date: Sept. 25, 2026 A man waits unknowingly inside a sting house. His eyes draw up to the sound of curtains ruffling as Chris Hansen (Robert Pattinson), host of Dateline NBC’s “To Catch a Predator,” enters flamboyantly. Hansen descends...
Dennis Hastert, longtime Republican House speaker who went to prison, dies at age 84
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Lawrence brothers take on missing ’90s stars in graphic novel, ‘The Lawrence Brothers Detective Agency’
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DHS buys three detention centers in California for $950 million
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Dennis Hastert, House speaker sullied by abuse case, dies at 84
Dennis Hastert, whose rise to US House speaker in 1996 was as unexpected as the criminal conviction that sullied his reputation and sent him to prison years later, has died. He was 84.
Dennis Hastert, longtime Republican House speaker who went to prison, dies at age 84
Dennis Hastert, the nation’s longest-serving Republican House speaker, whose own political legacy was forever fouled by allegations that he molested high school
Dennis Hastert, longtime Republican House speaker who went to prison, dies at age 84
Dennis Hastert, who served as House speaker longer than any other Republican but later was sent to prison in a hush-money case, has died.
Dennis Hastert, longtime Republican House speaker who went to prison, dies at age 84
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Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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