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Viewpoint: A career in science is possible, and worth it
Starting a career in science is exciting, but also demanding, with researchers often faced with intense competition, long working hours and high levels of stress. A pioneer in the field of mass spectrometry, Carol Robinson has been there. She speaks with Science|Business on the importance of creating a supportive environment, particularly for women.Robinson did not wake up one day thinking that she would become a scientist. It was only late in school that she developed an interest in chemistry. “The more you work at something, the more you think, actually, this is fascinating. So, I went much further and deeper than I ever needed to pass the exam. And then I loved it,” she says. “I thought, I’m going to give it my all. I’m going to enjoy it while I’m here. But I didn’t think this would be my career for 50 odd years.”She left school at 16 to become a lab technician with the drug company Pfizer, which is where she first worked with mass spectrometry. Fascinated, she was encouraged to take a part-time degree and then a PhD. She went on to do pioneering work in native mass spectrometry, a technique that is used to study protein structures in their natural state, paving the way for breakthroughs in drug discovery. She also broke new ground by becoming the first female professor of chemistry at the University of Cambridge, and then the first female professor of chemistry at the University of Oxford, her current home.She now wants to show young researchers that a career in science is worth it. “Sometimes, I believe the culture isn’t very encouraging, and that’s something I have worked on,” Robinson says.In 2021, she launched the Kavli Institute for Nanoscience Discovery at Oxford, whose acronym gives a sense of what she hopes it will achieve. “Maybe it is corny,” she says. “It’s just a reminder that I would like it if we could all be kind to each other and supportive, especially for early-career researchers of either gender, because there’s quite a big attrition rate in science, and maybe it just doesn’t feel like a very friendly place to work.”And yet, a career in science comes with a lot of flexibility. “There are few careers where you have that amount of freedom, to go to conferences, to the library. Just because you didn’t see me didn’t mean I wasn’t working,” she says. “And I’m excited to come in every day. So, I don’t want people to think it’s a terrible place.”Gender equality is also important when it comes to the quality of science as a career. “The more women we have, the better it becomes,” Robinson adds.Imposter syndromeAccording to EU data, women outnumber men in university education but account for just about a third of graduates in science, technology, engineering and mathematics (Stem). And while the number of women working as scientists and engineers in the 27-member bloc is on the rise, their representation remains below that of men, at 41%. This discrepancy is even more pronounced in top-tier functions across these fields, where women fill just 20% of positions.Having supervised many young scientists, Robinson sees that women continue to have a greater propensity than men to doubt their abilities, a feeling she once shared. “When I was doing my PhD at the University at Cambridge, I really felt like an imposter,” she says. “I don’t think I ever felt I deserved to be there or owned it and was proud. I just thought I was lucky.” Later on, she adds, “I was always that person who said, I can’t apply yet because my CV is not strong enough.”She has now made it her job to encourage women to break with this imposter syndrome. For example, rather than calling for volunteers to give a lecture in the groups that she mentors or teaches, which nearly always results in men stepping forward, she goes straight to the women, “because I know they won’t push themselves forward.”But the gender gap in science is not just down to imposter syndrome. The “obvious” reason, Robinson says, and the reason that is on everybody’s mind when discussing workplace gender equality, is the balance between work and raising a family. Her own path was to choose between the two, taking an eight-year break after completing a postdoctoral training fellowship to bring up three children. And she continues to advise women not to work part-time while they raise a family. “You’ll just get half the pay and continue to work full-time because you are not able to fit everything in,” she says. “You should be able to have a family and come back to have the career that you want.”The solution is for men to also take career breaks. “That kind of evens it up, so that it’s not such a big thing for women,” Robinson says. “I always encourage men in my groups to do that. I think it’s important to take your share of the duties.”Support produces resultsAccording to the Women in Stem Network, a UK advocacy group, countries with strong childcare systems and equal pay policies retain more women in technical careers. In Europe, these are primarily found in the Nordic region and parts of central Europe.At the EU level, the European Commission asks all Horizon Europe applicant organisations to have a gender action plan in place. Since this criterion was introduced in 2021, the share of women leading consortia has increased to 31%, against 23% in Horizon 2020. Their overall participation, however, has risen just 1%, to 38%. After trying to weaken the requirement for gender action plans in 2025, the Commission now intends to adopt a plan for supporting women in research and innovation.Related articlesCommission scraps plan to water down gender requirements in HorizonHow gender balance can swing who wins Horizon Europe fundingRobinson herself has benefited from three Advanced Grants from the European Research Council. “I was extremely honoured and privileged to get those, because they really allowed me to fuel my passion,” she says. “Without that, it would have been a much harder slog.”Beyond applying gender rules, she says that more work is needed on translational enterprise, where women are, once again, largely underrepresented. The European Patent Office found that only 13.8% of applications were filed by women in 2022. “We have so many more women doing amazing science; why do they feel it’s not a thing to have a company?” she asks.She founded her own spin-out company, OMass Technologies, in 2016, and remains chair of its scientific advisory board now that it trades as OMass Therapeutics. As for research, Robinson is now studying how changes in the brain may be linked to depression, using port-mortem tissue. “We’re hoping to publish soon,” she says. “We had to consult with a lot of people who knew a lot more about the brain than we did. So, we’ve learnt a lot, and that’s always a lot of fun to learn a new thing. That’s what keeps you going.”
Sony clarifies recent PlayStation DRM update
PlayStation fans and gaming preservations have been alarmed since late last week that a new 30-day timer attached attached to newly-purchased digital games for PlayStation 4 and 5 might render those games unplayable if the system they’re on is offline for longer than a month. But a rep from Sony told Game File today that new system will require only a single online check before it functions as a perpetual license for the digitally purchased game. That is consistent with a newer theory that emerged by gamers testing the 30-day timer over the last two days. “Players can continue to access and play their purchased games as usual,” a rep for PlayStation told me over email. “A one-time online check is required after purchase to confirm the game’s license, after which no further check-ins are needed.” The rep’s explanation squares with the current understanding among players about what’s happening. A multi-day mystery A post last Friday by YouTuber Lance MacDonald spread awareness over the 30-day timer. Quickly, players began stress-testing the system, removing a battery within their PlayStations and checking what would happen if their systems were offline past the timer window. They noticed that setting a PS4 or PS5 to be the “primary” console—a common Sony-authorized method to retain rights to a digital game—wasn’t overriding the 30-day limit. On Tuesday came the breakthrough: A gamer called Andshrew on the Resetera forums posted the results of some tasting. They found that digital games purchased on PS4/PS5 after some time in mid-April would get a 30-day timer that could then be removed and replaced with a perpetual license that would allow the game to be played offline. The transition to the perpetual license occurred some number of days after the digital game was purchased and the system was connected to the internet. They believed that a PlayStation’s online check-in would trigger the license change no sooner than 15 days after the user had purchased the game. This synced with the theory that Sony’s new system is related to the 14-day window that PlayStation users have to request a refund for digitally purchased games. The new timer/check-in system could be a way to defeat some exploit in that refund system, some users theorized. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe In a follow-up, I asked the Sony rep if the 15-day timeline is accurate or if the perpetual license can be activated sooner after purchase. If they share more, I’ll update this post. Sony has not said why they’ve introduced the timer and whether it is designed to stop people from exploiting the refund system. But their explanation suggests that this new DRM method should not result in long-term loss of access to digitally purchased games, just because a PlayStation is offline for a month or Sony’s servers are down. Xbox flashback For many some gamers, the initial reporting of the 30-day timer conjured memories of Microsoft’s disastrous May 2013 announcement of the Xbox One, which was going to require an internet-connected check-in once a day, lest your games become unplayable.1 After widespread backlash, Microsoft abandoned that plan, ahead of the Xbox One’s launch. 1 Fun fact: That 24-hour check-in detail was my scoop from an interview I had that day with then-Xbox exec Phil Harrison. I was EiC of Kotaku at the time and rushing from one Xbox One preview appointment on Microsoft’s campus to another. I phoned the news in to reporter Jason Schreier, who wrote it up for the site.
Brain function evaluations to be part of Marine health records
By September, Marines will be screened for blast exposure and overpressure during their periodic health assessments, a Pentagon official said.
Motorola Signature design highlight: Striking the perfect balance between form and function
This phone may look quite familiar, but it also proves that boring can be beautiful when executed this well.
Brain Health Across the Life Span: A Framework for Future Studies
This Scientific Statement focuses on the role of nonvascular physical and psychological factors that impact brain health, which is described as the optimal functioning of the brain across cognitive, emotional and behavioral domains throughout life.
10 things you can do every day to support your brain health
Many health factors can influence brain function later in life, according to the Alzheimer's Association's annual report. Here's what to know.
First Louisiana patient to receive sickle cell gene therapy heads home after 6 weeks in hospital
Learn about the groundbreaking gene therapy for sickle cell disease at Manning Family Children's Hospital in Louisiana, providing hope for a "functional cure".
Trump Terminates Entire National Science Board
govern the National Science Foundation (NSF). The National Science Board directs and approves large funding decisions for NSF’s approximately $9 billion basic science research budget. It is meant to function independently from the federal administration to keep science funding insulated from political pressure and budget cycles.
FTC crackdown pushes auto dealers to treat compliance as a core business function
Industry experts discuss the FTC crackdown, dealer transparency and how compliance, culture and pricing strategy impact M&A and valuation.
A Look At Accel Entertainment (ACEL) Valuation After Recent Share Price Momentum
Recent performance and business snapshot Accel Entertainment (ACEL) has attracted fresh attention after recent share price moves, with the stock showing positive returns over the past week, month and past 3 months, prompting investors to reassess its fundamentals. The company operates distributed gaming terminals, redemption devices with ATM functionality and other amusement equipment in non casino venues across the United States, including restaurants, bars, truck stops and convenience...
City and EDIC caters to new business
LYNN — When Brita Potenza was looking for space to grow her catering and event-hosting business, she visited the Lydia Pinkham Building and toured the space formerly occupied by Uncommon Feasts. On the wall was a photo of a function that had been held there. She recognized someone. “I looked over on the wall, and […]
The AI Tools Small Businesses Are Using - Small Business & Entrepreneurship Council
By Karen Kerrigan – Artificial intelligence is no longer experimental for small businesses. According to SBE Council’s 2026 Small Business Tech Use Survey, 82% of small business employers have invested in AI tools and they are rapidly being embedded across daily functions and workflows. In fact, AI has become essential to competitiveness and growth as […]
14th annual Southwest Colorado Small Business Conference coming to Ignacio in May
The 14th annual Southwest Colorado Small Business Conference promises to supply “practical strategies, fresh ideas, and valuable connections” for attendees from all industries. The conference, which ...
Could your beer have health benefits? Here’s what new research says
A casual beer might come with an unexpected perk. Drinking the occasional pint could provide “substantial levels” of vitamin B6, an essential nutrient that supports brain function, blood health and…
Congress keeps holding all-nighters. Lawmakers say it’s a symptom of dysfunction
It's a scenario that is playing out again and again as the House and the Senate fracture and careen from one crisis to the next.
Madrid Presents the Transformation Project of the Former Olympic Aquatic Center Site into a Multifunctional Complex for Sports, Entertainment, and Education
Barsento, the joint venture formed by Live Nation, Oak View Group (OVG), and Atlético de Madrid, has today presented the transformation project of the former Olympic Aquatic Center site alongside the Mayor of Madrid, José Luis Martínez-Almeida. The initiative will breathe new life into the unfinished Aquatic Center building, transforming…
New issue: Mirrorlife | BBC Science Focus Magazine
Mirror life could end all life on Earth. That sounds dramatic, but senior biologists have raised the alarm about experiments happening all around the world. It sounds like something in a Doctor Who plot, but no – mirror life is a real possibility. So why do scientists want to create something that’s potentially apocalyptic? Well, it could also have huge benefits (think back to splitting the atom). The first thing to say, however, is that mirror organisms are still a little way away yet – but only decades, not centuries. So far, scientists have only made mirror molecules, one of life’s building blocks. What for? Life works because its building blocks fit together. Imagine drilling a screw into a piece of wood. The screw cuts a hole with a thread that snugly matches its own. If, for some reason, the Doctor showed up and handed you a mirror version of the screw, its thread would be in reverse. It wouldn’t twist into the hole you’d just made as the threads wouldn’t match. That said, the mirror screw would still work; you’d just have to create a mirror hole for it. Mirror molecules, including DNA, work a bit like that. They follow the same principles as the biology around us, but they’re entirely incompatible with traditional biological functions. In medical terms, this means they’re effectively invisible to your body’s systems. Our biology doesn’t have the tools to recognise these molecules and break them apart. And if someone took these mirror molecules and put them together to make a cell and then an organism… you’d have mirror life. But we don't have any way of breaking it down. If it escaped the lab, we’d just have to hope it didn’t have an appetite.
Google updates Workspace to make AI your new office intern
Google has introduced a host of new automated functions into Workspace, all of which are driven by Workspace Intelligence, its new AI system.
Armageddon! Fiasco! Disarray! Is California politics really a total disaster?
Your morning catch-up: A look at California's political dysfunction, plus fraud in the state's hospice industry and more big stories
Mechanohealth: Where life science meets physical forces for health innovation
Integrating mechanobiological principles into disease pathogenesis, therapeutic development, and tissue engineering is reshaping our understanding of biological systems and accelerating the advancement of mechanotherapy and mechanohealth. This field reveals how mechanical cues regulate cellular behavior, such as force transmission along integrin-nucleus pathways and collective cell migration, and tissue functions. In doing so, mechanobiology connects fundamental research with clinical applications, from limiting cancer metastasis and fibrosis to promoting bone regeneration and maintaining vascular homeostasis. Building on discussion from the Inaugural International Conference on Mechanobiology (ICM) 2025, integrating mechanobiological research with clinical strategies offers new opportunities to address unmet needs, including personalized anti-fibrotic interventions or precision bone regenerative therapies. At the same time, it supports the broader concept of mechanohealth -- a paradigm focused on preserving the physiological mechanical balance within tissues.
Dario Demonstrates Improved Workplace Function and Productivity Outcomes Through Digital Behavioral Health Program: Real-World Study Published in JMIR Formative Research
/PRNewswire/ -- DarioHealth Corp. (NASDAQ: DRIO) (the "Company", "DarioHealth" or "Dario"), a leader in global digital health, today announced the publication...
Dario Demonstrates Improved Workplace Function and Productivity Outcomes Through Digital Behavioral Health Program: Real-World Study Published in JMIR Formative Research
/PRNewswire/ -- DarioHealth Corp. (NASDAQ: DRIO) (the "Company", "DarioHealth" or "Dario"), a leader in global digital health, today announced the publication...
Inside war-hit Sudan’s only functioning hospital curing tropical diseases
Sudan's health ministry says 37 percent of country's health facilities are out of service as war enters its fourth year.
Scientists unveil how heat-loving enzyme could help improve plastic recycling
Cutinases are fungal enzymes that naturally degrade plant cuticles and show promise for recycling plastics. However, they must balance structural rigidity to withstand high temperatures with flexibility required for catalysis. Now, researchers have investigated the structural basis of catalytic activation in a heat-tolerant cutinase, CtCut, from the fungus Chaetomium thermophilum and found that a rigid core supports stability while a flexible lid is associated with catalytic function, offering insights for improving enzymes for plastic recycling.
Multifunctional ligand engineering for pure-blue halide perovskite nanocrystal LEDs
Light: Science & Applications - Passivation with a bifunctional fluorinated ligand stabilizes mixed-halide perovskite nanocrystals, enabling high-color-purity deep-blue emission...
Can Claude Write Z80 Assembly Code?
Betteridge’s law applies, but with help and guidance by a human who knows his stuff, [Ready Z80] was able to get a functioning game of Wordle out of the French-named LLM, which is more than w…
$3 million prize goes to duo whose research led to first sickle cell CRISPR therapy
Dr. Swee Lay Thein and Dr. Stuart Orkin won the $3 million Breakthrough Prize in Life Sciences for their work toward a functional cure for the deadly blood disorders sickle cell disease and beta thalassemia.
$3 million prize goes to duo whose research led to first sickle cell CRISPR therapy
Dr. Swee Lay Thein and Dr. Stuart Orkin won the $3 million Breakthrough Prize in Life Sciences for their work toward a functional cure for the deadly blood disorders sickle cell disease and beta thalassemia.
Apple to Unveil iOS 27 in June With These New Features Beyond Siri
Apple is expected to unveil iOS 27 during its WWDC 2026 keynote on June 8, and the update should be released in September. Below, we outline some of the new features that are rumored to be coming with iOS 27, beyond the long-awaited more personalized version of Siri. iOS 27 will reportedly support 5G satellite internet connectivity, although this functionality might be limited to the upcoming iPhone 18 Pro models with Apple's next-generation C2 modem.
Super-agers have healthy cognitive function
I just read about people who are called super-agers and how they don't have the memory problems that happen when you get older. Supposedly they have more brain cells. Do you know if that's true? The idea of super-agers is really interesting, and I want to know more.
Childhood Acid Load May Affect Adult Kidney Health
Higher net acid excretion in childhood and adolescence is linked to signs of declining kidney function in adulthood.
4 New Apple Intelligence Features Found in Apple Code, Likely in iOS 27
iOS 27 is likely to introduce at least four new Apple Intelligence features that function within system apps, based on backend code discovered by Nicolás Alvarez and confirmed by MacRumors. First up, Apple is expected to lean more heavily into Visual Intelligence in iOS 27, since the company is reportedly developing AI wearable devices that will leverage the feature. Apple is reportedly working on smart glasses, AirPods with cameras, and a wearable AI pin or pendant.
UnityPoint Health outsourcing to eliminate hundreds of jobs
UnityPoint Health says it is cutting IT and revenue cycle positions, outsourcing those functions to reduce costs.
Nas.com secures $27M to aid solo entrepreneurs with AI tools
Nuseir Yassin's startup, Nas.com, uses AI tools to help entrepreneurs with a range of business functions like marketing and storefront design.
Building Custom Atomistic Simulation Workflows for Chemistry and Materials Science with NVIDIA ALCHEMI Toolkit
For decades, computational chemistry has faced a tug-of-war between accuracy and speed. Ab initio methods like density functional theory (DFT) provide high fidelity but are computationally expensive…
You can order your own bloodwork now. Interpreting the results is another story
Firms like Function Health and Oura market regular blood tests to people wanting to take their health into their own hands. The process often raises more questions for patients than it can answer.
Fluoride in drinking water has no effect on IQ or brain function, major study shows
The new research is the first to measure community water fluoridation exposure during childhood in the U.S. and any potential impact on cognition up to age 80.
Trump, 79, Raises Fresh Health Concerns After Unbelievable Mix-Up
The president’s feeble reasoning sparked questions about his cognitive function.
Erectile dysfunction is more than a sexual issue
Erectile dysfunction is more than a sexual issue.
Ska Brewing sale breathes new life into 30-year-old business
Ska Brewing Co. in Durango has survived more than 30 years of shifting economic landscapes, a pandemic, a multiyear decline for craft breweries on the whole and a recent change of ownership after deca...
Health expert explains link between women's hormones, stress
Functional medicine practitioner Jennifer Gularson highlights how physiological shifts like menopause can trigger significant stress and hormone imbalances.
FULL SHOW: Inside INdiana Business 4/12/26
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New clinic brings at-home health care to La Plata, San Juan counties
HERMOSA – The practice of a doctor traveling to a patient’s home to deliver care – as opposed to the patient traveling to a medical campus or visiting a doctor in an office – is largely bygone. Accord...
Life on Mars? Tiny cells just survived shock waves and toxic soil
Mars may be hostile, but it might not be entirely unlivable. In lab experiments, yeast cells survived simulated Martian shock waves and toxic perchlorate salts—two major environmental threats on the Red Planet. Their secret weapon was forming protective molecular clusters that shield critical cellular functions under stress. Without these defenses, survival plummeted, pointing to a potential universal strategy life could use beyond Earth.
Bridging Oral Health and Integrated Care: A Scientometric Study of Integrated Care for Older People (ICOPE) and Removable Prosthodontics in Older Adults
Population aging has shifted healthcare priorities from disease-centered models towards functional ability and quality of life. The WHO Integrated Care for Older People (ICOPE) framework operati...
Al Roker stops 'Today' interview with 'Laguna Beach' star over wardrobe malfunction: 'Guys, on live television?'
'Laguna Beach' star handled a wardrobe malfunction that occurred on live TV like a pro Friday on 'Today.'
Microsoft Starts Removing Copilot from Notepad, Snipping Tool, and More in Windows 11
Microsoft's Copilot AI has generated significant negative sentiment among Windows 11 users, to the extent that even Microsoft has recognized the need to scale back some of the Copilot functionality it has long promoted. According to Windows Latest, Microsoft has updated core Windows applications suc...
Peru's Dysfunctional Politics Are an Economic Time Bomb
Peru has gone through three presidents since October, yet markets have largely yawned: Country risk has edged up only marginally, credit default swaps remain well below their five-year average and the currency has even gained against the dollar.
‘One of the most dysfunctional places’: One lawmaker on Lansing’s challenges
Calling the state capitol “one of the most dysfunctional places” in America, Democratic State Rep. Alabas Farhat joins the pod for a candid conversation about the challenges facing Lansing
WhatsApp Gets New CarPlay App
Facebook-owned messaging app WhatsApp was today updated with expanded support for CarPlay. CarPlay users are able to more easily call and message their friends and family members in WhatsApp directly from the car interface. WhatsApp had CarPlay integration before, but with limited Siri-based functionality. The new app has a full native CarPlay interface with a list of recent chats and call history, along with a tab for favorite contacts.
45-year-old longevity researcher: How I keep my body and brain healthy—it's what 'your grandmother probably told you to do'
Jamie Justice's research focus is how to "prevent or delay the onset of functional declines, disability or chronic diseases" as people age, she says.
5 Things You Didn't Know Your Apple Watch Can Do In 2026
Your Apple Watch brings you a ton of capability to your wrist -- calls, texts, exercise tracking, etc. -- but there are more functions you should know about.
Opinion: Why Alaska may point to the future of independent politics
Rather than labeling themselves as independents in protest of dysfunctional Republicans and Democrats, the title now stands for pragmatism and common-sense.
Study Reveals the Single Cause of Cognitive Decline—and a Cure
Researchers pinpoint a lone protein that speeds up the dysfunction of an aging brain. Eliminating it, they claim, can reverse the damage.
FULL SHOW: Inside INdiana Business 4/5/26
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State rankings: How are the Durango High spring sports doing?
April is here, and that means it’s time to look at the progress of the Durango High School spring sports teams. Demons sports squads have been practicing for over a month and have been competing in ga...
What the Muppets can teach us about Maine politics
For dreamers like me, the Rainbow Connection seems distant. Our political climate has abandoned what I consider the Muppet spirit: a celebration of wistfulness, a collective made strong by diversity and humble and transparent leadership. Contemporary politics has been like shadow puppets: projections designed to obscure the causes of our dysfunctional society. The Muppets offer […]
What the Muppets can teach us about Maine politics
For dreamers like me, the Rainbow Connection seems distant. Our political climate has abandoned what I consider the Muppet spirit: a celebration of wistfulness, a collective made strong by diversity and humble and transparent leadership. Contemporary politics has been like shadow puppets: projections designed to obscure the causes of our dysfunctional society. The Muppets offer […]
8 Of The Best Smart Home Gadgets For Minimalists
These sleek, efficient smart home gadgets are functional, stylish, clutter-free, and perfect for minimalists building a clean, tech-savvy space.
Apple CarPlay Just Got Three Popular iPhone Apps
Apple's CarPlay system for accessing iPhone apps on a vehicle's dashboard screen received three popular apps this week: ChatGPT, Google Meet, and Audiomack. CarPlay Ultra in an Aston Martin In addition, WhatsApp is beta testing a revamped CarPlay app that will improve upon the basic Siri-based functionality that was previously available. Make sure you have the latest version of each app and they will automatically appear on CarPlay.
Binge drinking just once a month may triple your risk of liver scarring
Many people think that occasional binge drinking is harmless if they otherwise drink in moderation, but new research suggests that assumption may be dangerously wrong. A large U.S. study found that people with metabolic dysfunction–associated steatotic liver disease (MASLD), a condition affecting about one in three adults, face a much higher risk of serious liver scarring if they engage in heavy drinking even just once a month.
From The Drama to Malcolm in the Middle: your complete entertainment guide to the week ahead
R-Patz and Zandaya star in a romcom with bite, and the lovably dysfunctional family is back in a revival of the turn-of-the-millennium comedy hit
Carbon Emissions in a War-Torn World Threaten Brain Health
The combination of global warming and wars may deliver a double whammy to normal brain function.
WHO’s head of emergencies reaffirms support to Lebanon’s health system amid escalating needs
Lebanon’s health system continues to function despite the mounting pressures of conflict, displacement and repeated attacks on health care – but without urgent action and sustained international support, access to essential health services is increasingly at risk.
Assistant Beamline Scientist Grace Luo is facilitating next-generation science at the Advanced Photon Source
At Argonne’s Advanced Photon Source (APS), Grace Luo helps scientists understand atomic‑scale dynamics in functional devices to discover ways of creating more robust and efficient technologies.
Iterative Health, US Heart & Vascular Partner to Advance Community-Based Cardiovascular Research
April 2, 2026 — Iterative Health and US Heart & Vascular (USHV) have announced a strategic partnership to advance research through community-based innovation in cardiovascular care. "Clinical research is one of the most powerful ways we expand access, improve patient outcomes, and shape the future of cardiovascular care," said Robbie Allen, chief executive officer of US Heart & Vascular. "By partnering with Iterative Health, we are strengthening our ability to bring innovative therapies directly into the communities we serve. This collaboration ensures our physicians and patients have access to leading-edge trials while allowing US Heart & Vascular to remain focused on delivering exceptional, physician-led care." Under the agreement, USHV research sites will join Iterative Health’s global site network, which now spans over 100 sites across three continents. The companies share a commitment to advancing clinical research as a driver of care innovation, and this collaboration represents a major milestone for both organizations, strengthening USHV's leadership in community-based cardiovascular research and expanding Iterative Health's multispecialty focus beyond GI, hepatology, and obesity into cardiology. USHV clinical research sites will gain access to Iterative Health's centralized operational backbone, providing end-to-end support across clinical research operations, services, business development, technology innovation, and corporate functions. The strategic partnership reduces operational complexity and unlocks growth potential for USHV research sites while enabling all USHV physicians to expand access to cutting-edge therapies to the thousands of patients they serve annually. "Innovation in cardiovascular medicine shouldn't be limited to a few academic centers," said Thomas Waggoner, DO, MD, RPVI, FACC, FSCAI, FSVM, RPVI, Structural Cardiologist and Medical Director for Clinical Research at Pima Heart & Vascular, and USHV Physician Champion for Clinical Research. "By expanding community-based research across USHV, we're ensuring more patients have access to clinical trials and breakthrough therapies close to home, where trusted relationships with their physicians already exist." This alliance reinforces Iterative Health's standing as the definitive research partner across specialized therapeutic areas, now spanning GI, hepatology, obesity, and cardiovascular care. Trusted by many of the nation's leading provider organizations and biopharma sponsors, Iterative Health's global site network delivers industry-leading trial performance, accelerating life-changing therapies to market at scale. "Entering cardiology through our strategic partnership with US Heart & Vascular is a defining moment for Iterative Health and reflects the strength of our site-serving model," said Jonathan Ng, founder and CEO of Iterative Health. "Together, we are ensuring that thousands of patients have access to the newest available therapies, and that sponsors have a credible, high-performing partner to accelerate cardiovascular trial success." For more information, visit www.iterative.health and https://usheartandvascular.com/.
Anthropic Says That Claude Contains Its Own Kind of Emotions
Researchers at the company found representations inside of Claude that perform functions similar to human feelings.
Google Photos app launches on Samsung TVs – here’s what it can do
There's a new Google Photos app on Samsung TVs, but only on the 2026 models, and it only has limited functionality.
Why the 35th Senate District race could reshape Lansing politics
We are two months away from the special election that will determine the functional make-up of the state Senate. The 35th Senate district election is an important race that has folks in Lansing wondering what comes next.
Could probiotics, dietary changes help protect brain health as we age?
A new review looks at how probiotics, prebiotics, dietary changes, and fecal microbiota transplants can help support gut health and preserve brain function as people age.
Local sports schedule for upcoming week
April is here, and that also means local spring sports teams are entering the heart of their seasons. This month is the lone month in the spring sports season where teams will have games from the sta...
Airbnb Externship Shows 3L Isabel Samayoa How Legal Strategy Drives Business Growth - UC Law San Francisco (Formerly UC Hastings)
An externship at Airbnb provided 3L Isabel Samayoa exposure to areas such as contracts, licensing, risk management, and growth strategy, helping her develop the skills and experience to thrive in her future career as a corporate transactions attorney. 3L student Isabel Samayoa reflects on her work with Airbnb’s in-house legal team through UC Law SF’s Corporate Counsel Externship Program. Supported Airbnb’s legal team on commercial contracts, open-source licensing, external partnerships, product counseling, and legal research. Observed how legal advice aligns with business strategy and risk management. Gained exposure to strategic decision-making while preparing for a career in corporate transactions. Q: What did you do in this corporate externship? A: I supported the Airbnb legal team across several functions, including commercial contracts, open-source licensing matters, strategic external partnerships, legal research, real estate matters, internal AI integration, and product counseling. I also gained exposure to corporate structure counseling, litigation, patent counseling, and the company’s broader business strategy. Q: What did you take away from this experience? A: One of the most valuable parts of this experience was learning how a business actually operates. I had never worked on such a large team in the private sector, so I had little exposure to how companies run internally. I learned how lawyers can provide valuable advice to support business goals, seeing how leadership evaluates risk and develops growth strategies. Understanding those priorities allows me to calibrate my legal advice to clients, balancing the client’s goals against the level of risk they are willing to take. Q: How does this experience support your career goals? A: Exploring the anatomy of a successful company was incredibly valuable because I plan to pursue a career as a corporate transactions lawyer. Being in the room with the teams discussing important decisions allowed me to see firsthand the factors that contribute to that success and how lawyers help guide those decisions. Q: Would you recommend UC Law SF and this externship? Why? A: I would absolutely recommend this opportunity. While the team worked on high-stakes matters at a highly successful company, they still created an environment where I felt welcomed. They trusted me with meaningful work and supported me every step of the way. This helped me build confidence in my analytical abilities. Q: What’s your favorite UC Law SF memory so far? A: Some of my favorite UC Law SF memories, aside from my time at Airbnb, involve mentorship. I have benefited from mentorship and have also had the chance to mentor other law students. Watching the students I mentored go on to mentor others has been particularly rewarding. I think mentorship is integral to the legal profession, and it has been inspiring to see that culture thrive at UC Law SF and continue beyond the classroom. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
Scientists Build Five-in-One “Super Molecule” for Next-Gen Electronics
A hybrid synthesis strategy enables complex molecular architectures to function as a single electronic system.
Pittsburgh black-owned businesses express frustration over NFL draft selection process
B. Marshall, Juneteenth promoter, said, "They are contracting businesses to work for the NFL to do certain functions."
Whole Hog Politics: A top-down crisis in democratic legitimacy
If you’d like to understand the special kind of political dysfunction that paralyzes American politics, just consider two numbers: 16 and 97. You live in a country where Congress has a 16 percent job approval rating and...
One UI 9 may bring a tap to share feature like Apple’s NameDrop
Samsung is building a new Tap to share feature that's similar in form and function to Apple's NameDrop feature.
Canadian Adults’ Functional Health Has Declined
Worsening emotional health and increased prevalence of pain are the main causes of the decline in Canadians’ functional health from 2015 to 2024, says Statistics Canada.
Science Central unveils new planetarium
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FULL SHOW: Inside INdiana Business 3/29/26
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Stroke triggers a hidden brain change that looks like rejuvenation
After a stroke, the brain may do something surprisingly hopeful—it can “refresh” parts of itself. Researchers analyzing brain scans from over 500 stroke survivors found that while the damaged side of the brain appears to age faster, the opposite, unaffected side can actually look younger. This unexpected shift seems to reflect the brain’s effort to rewire itself, strengthening healthy regions to compensate for lost function.
Apple Releasing Two New iPhone Apps This Year
Apple is expected to release two new iPhone apps this year, including an Apple Business app and a Siri app with chatbot-like functionality. With the Apple Business app, employees at businesses using the new Apple Business platform will be able to install apps for work, view contact information for colleagues, and request support. Apple Business is launching on April 14, and it replaces Apple Business Essentials, Apple Business Manager, and Apple Business Connect.
This new carbon material could make carbon capture far more affordable
Scientists have created a new kind of carbon material that could make carbon capture much cheaper and more efficient. By carefully controlling how nitrogen atoms are arranged, they found certain structures capture CO2 better and release it using far less heat. One version works at temperatures below 60 °C, meaning it could run on waste heat instead of costly energy. The discovery offers a powerful new blueprint for next-generation climate technology.
Scientists discover a hidden system that turns brown fat into a calorie burner
Scientists have identified a key biological system that helps brown fat burn energy by building the networks it needs to function. A protein called SLIT3 splits into two parts, with each piece guiding the growth of blood vessels and nerves inside brown fat. These structures allow the tissue to pull in nutrients and rapidly convert them into heat instead of storing them as fat.
Pokémon GO Datamine Reveals Explorer Gadget, a Virtual Auto-Catching Item
Trainers, a new in-game item that could fundamentally change we Trainers play Pokémon GO has been spotted in the game’s code. According to a recent datamine by the ever-watching PokeMiners, Scopely is working on an item called the Explorer Gadget, which appears to replicate the functionality of physical auto-catching devices like the GO Plus and […]
Understanding protein motion could greatly aid new drug design
For many of us, “protein” is the key element of a food order. However, beyond your preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose chemical structure is encoded in our genes. Proteins have critical functions in living cells: They help repair and build body tissues, drive metabolic reactions, maintain pH and fluid balance, and keep our immune systems strong.
Why Wild Blueberries Are Getting Attention for Heart and Metabolic Health Benefits
Wild blueberries may support heart health by improving blood vessel function, lowering blood pressure, and aiding cholesterol and blood sugar control.
Top 'I told you so' moments in the history of science
Talking about how science functions and malfunctions is important for people to understand.
DJI’s Avata 360 is a more functional, flexible 360 drone
There’s a second 360-degree drone in town — except in the US.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Bioresorbable microneedles track organ health
Nature Reviews Bioengineering - An article in Nature Biomedical Engineering reports a bioresorbable flexible microneedle sensor array for continuous monitoring of organ function for at least 7...
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Why REI treats CX as a critical business function
The outdoor retailer is focused on doubling down on its differentiators, REI’s Clay Walton-House said. That means investing in its elevated services and member experience.
Scientists say NAD+ could slow aging and fight Alzheimer’s and Parkinson’s
A global team of leading scientists is zeroing in on a tiny but powerful molecule that could reshape how we age. Known as NAD⁺, it plays a crucial role in keeping our cells energized, repairing DNA, and maintaining overall health—but its levels steadily decline over time, potentially fueling diseases like Alzheimer’s and Parkinson’s. Researchers are now exploring ways to boost NAD⁺ using compounds like NR and NMN, with early studies hinting at improvements in memory, metabolism, and physical function.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Microsoft Promises Slew of Windows 11 Changes in Response to "Microslop" Criticisms
With every Windows 11 update seemingly introducing a new bug or somehow breaking some core functionality, it seems as though trust in Microsoft and Windows is at an all-time low, with the recent "Microslop" insult popping up in online tech circles as a sort of culmination of the recent spate of issu...
One arrested, another cited in shoplifting incident at business on East Avenue in Chico
CHICO, Calif. - A Paradise man was arrested and a Forbestown woman was cited by Chico Police in connection to a shoplifting incident at a business in Chico.The Chico Police Department says that at around 12:30 p.m. on Wednesday, March 18, a loss prevention employee observed two suspects stealing several items from a retail business on the 700 block of East Avenue in Chico.Upon exiting the building, the two suspects, a man and a woman, were contacted by the loss prevention employee regarding the stolen items. The employee was able to persuade both suspects to return to the store and hand over the items they had stolen.Authorities say the business expressed their desire to press charges against the suspects and contacted Chico Police to report the crime.Officers reviewed video surveillance that confirmed the employee's account of what happened. Officers then made arraignment for both suspects to turn themselves in the following day.When the suspects, identified as 51-year-old Jamie Leal of Forbestown and 62-year-old Melvin Royal of Paradise, arrived the next day to turn themselves in, authorities say both admitted to their involvement in the incident and elected to write handwritten apology letters to the business.Leal was cited by Chico Police on a misdemeanor charge of shoplifting.Royal was taken into custody and transported to the Butte County Jail, where he was booked on the following charges:Shoplifting with 2+ priors (felony)Shoplifting (misdemeanor) googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Men are losing a key chromosome with age and it may be deadly
Aging men often lose the Y chromosome in a growing number of their cells—and it may be far more dangerous than once believed. This loss has been linked to heart disease, cancer, Alzheimer’s, and shorter lifespans. Researchers suspect Y-less cells may grow faster and disrupt normal body functions. What seemed like a minor genetic quirk could actually be a major driver of age-related disease.
Treasury Department to take over some federal student loans, as Trump administration works to dismantle Education Department
The Treasury Department will begin to manage federal student loans in default, taking on a key function of the Education Department as the Trump administration further pushes to dismantle it.
Providence May Sell Off Health Insurance Business
The Providence Health Plan was already outsourcing some of its core functions, but had previously denied it had plans to sell.