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Hatfield Marine Science Center celebrates blue whale skeleton
Oregon State University’s Hatfield Marine Science Center in Newport will hold a celebration of its recently installed 70-foot-long blue whale skeleton this week.
Hatfield Marine Science Center celebrates blue whale skeleton
Newport's Hatfield Marine Science Center celebrates its new 70-foot blue whale skeleton, one of only five on display in the U.S., a decade after it washed ashore in Oregon.
At Family Science Night, Wonder Comes Before Answers.
BAR HARBOR—Family Science Night isn’t really about science. It’s about wonder. It’s about watching a five-year-old realize that the tiny creature under a microscope is a real living thing. It’s about a teenager discovering that the scientist explaining genetics or regeneration isn’t much older than they are. It’s about parents seeing curiosity spread across a child’s face the way excitement spreads across a crowd at a Fourth of July parade. For one evening, families realize that the laboratory isn’t some secretive place where knowledge is hidden behind white coats and closed doors. They learn that the lab is a place their neighbors work, their friends’ parents work, and it becomes a place where questions matter more than answers. It’s a place where wonder is the origin for knowledge. At the lab, children learn that it’s okay not to know. Adults remember that they once asked “Why?” about everything. Scientists are reminded why they fell in love with discovery in the first place. There are experiments, games, obstacle courses, and demonstrations, of course. But those are really just invitations—to touch, to explore, to laugh, to make mistakes, and to ask one more question. In a world that often rewards certainty, Family Science Night celebrates curiosity. And perhaps that’s its greatest gift. Long after the microscopes are packed away and the experiments are over, what families take home isn’t just a few new facts about biology. They take home the feeling that discovery belongs to everyone—that science isn’t something happening somewhere else by someone else. It’s simply what happens when people are given permission to wonder. A Family Science Night at the Mount Desert Island Biological Laboratory is one of those rare community events where children and adults can experience science as something they do, not just something they read about. Hands on discovery allows hands-on learning and joy. Real scientists, some local, some scientist-interns (but still scientists) just in college make science real, approachable, and exciting. And there, complex ideas like forever chemical-filtration, DNA and so much more become not complex. Instead, they become fun. Summer fellows are challenged to explain cutting-edge biomedical research in ways a first-grader—and their grandparent—can understand. Past activities have explored gene expression, kidney function, axolotl regeneration, worms, microplastics, and phytoplankton through games and creative demonstrations. Though it’s called family night, you can also see adults going from station to station, exploring, learning together across ages. Family Science Night reflects the laboratory’s broader mission of breaking down barriers between researchers and the public, helping people understand how scientific discoveries relate to everyday life and the health of Maine’s environment. Family Science Night transforms a world-class research laboratory into a giant interactive classroom, where curiosity is encouraged, questions are celebrated, and families discover that science isn’t just something that happens in a lab—it’s an adventure anyone can join. About MDI Biological Laboratory For more than 125 years, MDI Bio Lab has been a center for training and research in comparative biology. In the last two decades its biomedical research has focused on aging, regeneration, and environmental toxins. The Laboratory houses 11 research groups staffed by an international team of world-class scientists and graduate students. It also leads a statewide network of colleges, universities and research institutions that collaborate to provide training, research experiences and financial support to help young Mainers play a bigger role in today’s biomedical revolution. Located on Maine’s rugged coast, the Laboratory’s 100+ acre campus houses research facilities, cottages and dorms that house visiting scientists and students. It is also home to MDI Bioscience, a subsidiary working to design innovative techniques to speed the drug discovery process. LINKS TO LEARN MORE NIH INBRE MDI BIOLOGICAL LABORATORY Photos: Carrie Jones and Shaun Farrar/Bar Harbor Story HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment
First Baptist Church of Burlington celebrates pastor's 3rd anniversary
BURLINGTON, Ohio — On July 12, the First Baptist Church of Burlington will celebrate the third Pastoral Anniversary of Rev. LaShawn Kaigler with guest preachers Rev. Reginald Hill, Pastor Emeritus
HOMETOWN ENTERTAINMENT: Erin Lunsford celebrates ‘Rhinestones’ album release with Roanoke show
Fincastle native Erin Lunsford brings her new album Rhinestones to Roanoke’s The Spot on Kirk Saturday night.
Vanderbilt Health celebrates 100 years of membership in the American Hospital Association
Presented as part of the AHA Membership Milestone Awards, this recognition celebrates organizations whose longstanding partnership has helped strengthen hospitals and improve the health of communities across the nation.
Mid-America Science Museum celebrates scientist’s 170th birthday with Tesla Fest Saturday
Mid-America Science Museum will host their annual Tesla Fest on Saturday in celebration of Nikola Tesla's 170th birthday.
NFIB Celebrates Ohio’s No. 1 CNBC Business Ranking
Ohio’s small businesses praise business-friendly climate.
Ubisoft Barcelona Celebrates Successful Assassin's Creed Black Flag Resynced Launch With Layoffs
51 Employee's, many of whom worked on Assassin's Creed Black Flag Resynced will celebrate its launch with being laid off.
‘A special place to be’: Fussell’s in Dickson celebrates 90 years in business
On North Main Street in Dickson, it may look like a men’s clothing store, but you’re stepping into nearly 90 years of local history.
Delaware weed industry celebrates veto override
Delaware's marijuana businesses received good news from a veto override in the wee hours of July 1.
Fermilab marks 70 years of neutrino science and leads next-generation experiment
As Fermilab commemorates 70 years since the discovery of the neutrino at the Savannah River Site in the United States, the lab also celebrates its multiple generations of pioneering neutrino research. Today, Fermilab is building the next era of neutrino discovery through the development of the world-leading Deep Underground Neutrino Experiment.
NYC Health + Hospitals/Elmhurst Celebrates New Point-of-Care MRI with Queens Borough President Donovan Richards
NYC Health + Hospitals/Elmhurst and Queens Borough President Donovan Richards recently held a ribbon-cutting to celebrate the arrival of a new point of
Behavioral Health Art Show Celebrates Creativity and Personal Growth
County Behavioral Health Services brought creativity and community together on June 12 at the Southeastern Live Well Center for its annual Strengths Based Case Management Art Show. More than a showcase, the art show highlights how creativity can open doors to healing and give participants a chance to be seen for their talent, not their challenges.
U.S. Army Hawaii celebrates 250 years of American independence at Schofield Barracks
SCHOFIELD BARRACKS, Hawaii — Thousands of Soldiers, families and community members gathered on Weyand Field July 4 to celebrate the 250th anniversary of...
Luv Handlz celebrates four years in business with community event, unveils new froyo truck
Families stopped by Luv Handlz on Sunday as the Syracuse frozen yogurt shop celebrated four years in business with a customer appreciation event.The celebration
America celebrates its 250th birthday after another rough year
War, inflation and presidential grifting mark an Independence Day best put in the past. But America has made it through worse times, which lends perspective and offers hope for better times ahead.
Fireworks, heat, hot dogs and politics: America celebrates its 250th birthday
WASHINGTON — The 250th anniversary of American independence is colliding with a country gripped by political polarization and a heat wave bearing down on millions of people across multiple states
In Fourth of July Speech, Trump Celebrates America and Derides Foes
A centerpiece address for the nation’s 250th anniversary celebration devoted time to American history, but had all the hallmarks of a Trump rally.
Fireworks, heat, hot dogs and politics: America celebrates its 250th birthday
WASHINGTON (AP) — The 250th anniversary of American independence is colliding with a country gripped by political polarization and a heat wave bearing down on millions of people across multiple sta…
Fireworks, heat, hot dogs and politics: America celebrates its 250th birthday
President Donald Trump plans to speak on the National Mall before what is being billed as a historically enormous fireworks show that will rain down over the nation's capital.
Fireworks, heat, hot dogs and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway on Saturday.
Fireworks, heat, hot dogs and politics: America celebrates its 250th birthday
The signing of the Declaration of Independence, one of history’s most celebrated articulations of democratic ambitions, is being marked in myriad ways.
Fireworks, heat, hot dogs, and politics: America celebrates its 250th birthday
An extreme heat wave canceled some celebrations, but across the United States people gathered to mark the historic anniversary.
Fireworks, heat and politics: America celebrates its 250th birthday
Anticipation for the milestone holiday has been building for much of the year, serving as an opportunity for Americans to reflect on their complicated history.
Fireworks, heat and politics: America celebrates its 250th birthday
WASHINGTON (AP) — The 250th anniversary of American independence is colliding with a country gripped by political polarization and a heat wave bearing down on millions of people across multiple sta…
Fireworks, heat and politics: America celebrates its 250th birthday
WASHINGTON — The 250th anniversary of American independence is colliding with a country gripped by political polarization and a heat wave bearing down on millions of people across multiple states as celebrations get underway across the United States on Saturday. The signing of the Declaration of Independence, one of history’s
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
Fireworks, heat and politics: America celebrates its 250th birthday
WASHINGTON — The 250th anniversary of American independence is colliding with a country gripped by political polarization and a heat wave bearing...
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
MRN BUSINESS SPOTLIGHT — Sheryl Scarbrough, TCBY
Today on Business Spotlight, brought to you by Bank of Springfield, Crissie Caccamo sits down with Sheryl Scarbrough, owner and operator of TCBY Quincy. Did you know TCBY stands for The Country’s Best Yogurt? As the Quincy favorite celebrates 40 years of serving the community, Sheryl shares the story behind the business, the legacy her...
Fireworks, heat and politics: America celebrates its 250th birthday
WASHINGTON (AP) — The 250th anniversary of American independence is colliding with a country gripped by political polarization and a heat wave bearing down on millions of people across multiple sta…
Fireworks, heat and politics: US celebrates its 250th birthday
fireworks are scheduled to be set off Saturday over Navy Pier in Chicago and against the skyline of New York City.
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
America celebrates 250 years with fireworks, heat and politics
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
Fireworks, heat and politics: America celebrates its 250th birthday
The 250th anniversary of American independence is colliding with political polarization and a heat wave as celebrations get underway across the United States on Saturday.
Brunch Box celebrates four years in business with new homemade donut
A local food truck known for serving up brunch across the Tri-Cities is celebrating a milestone with a sweet new addition.Brunch Box is celebrating four years i
11 ideas from UC Berkeley Haas that changed American business - Haas News
As America celebrates its 250th birthday, we're celebrating a few of the ideas born at UC Berkeley Haas that helped shape American business.
Entertainment agency marks 25 years with Disney
UK recruitment agency Excellent Entertainment celebrates 25-year partnership with Disney Cruise Line, sourcing thousands of entertainment professionals.
Probi celebrates 35 years of science and a new chapter with Symrise
Together, the companies are creating new opportunities to accelerate research, expand innovation and bring new and exciting biotic solutions to customers and consumers around the world
News: Seiko Creates A One-Off With The Star Time Watch For Shohei Ohtani
✓ Seiko celebrates Shohei Ohtani's 10th anniversary its ambassador with the Star Time ✓ A mechanical watch that tracks up to a million hours ✓
Trinity Health System School of Medical Laboratory Science celebrates 2026 graduates
STEUBENVILLE — The Trinity Health System School of Medical Laboratory Science graduated its seventh class, comprised of Aliyah Pattie and Audrey Poole. The graduation ceremony was held in the chapel at Trinity Medical Center West, followed by a reception in the Sullivan Room. Trinity’s Medical Laboratory Science program spans 11 months and is designed for […]
NASA celebrates Fourth of July with some cosmic fireworks
The release also includes new sonifications of red, white, and blue nebulae and galaxies.
American College of Cardiology celebrates 100 hospitals for offering ‘highest level of cardiovascular care’
These "forward-thinking organizations" have all committed to participating in multiple data registries and quality improvement programs. Did your facility make the cut?
Track & Field Alum Pablo Almaguer Celebrates Induction into RGV Sports Hall of Fame
RIO GRANDE VALLEY – The week of Pablo Almaguer's induction into the Rio Grande Valley Sports Hall of Fame for his success as the head girls track & field and cross country coach at Weslaco High School, he was asked if he ever envisioned such an honor coming his way.
New Jersey Business Magazine Celebrates America's 250th Birthday, NJ's Contributions
This special July edition of New Jersey Business Magazine celebrates America’s 250th birthday with an array of feature stories highlighting the state’s top industries. The magazine, which is powered by NJBIA and is the Garden State’s longest standing business publication dating back to 1954, explores the historical significance of these industries and how they complement the nation’s semiquincentennial birthday. “We approached this issue as[...]
Congress celebrates 'Spirit of '76' for semiquincentennial
Each year, millions of Americans stream through the Capitol Visitor Center to see how our country’s legislative body works
Congress celebrates 'Spirit of '76' for semiquincentennial
Each year, millions of Americans stream through the Capitol Visitor Center to see how our country’s legislative body works
FSU Jim Moran Institute celebrates completion of entrepreneurship bootcamp for veterans' families
Florida State University’s Jim Moran Institute for Global Entrepreneurship (JMI) celebrated the successful completion of its 2026 Entrepreneurship
Events in VT go big for July with Weird Al, Jack White and Thundercat
The Vermont Comedy Club, Higher Ground and the von Trapp Family Lodge & Resort all have plenty to offer as America celebrates its 250th birthday.
Greater Savannah Black Chamber of Commerce celebrates small business grant recipients
Eleven small businesses completed the program and received grant funding.
Business Owner with Down Syndrome Expresses 'Gratitude' as He Celebrates First Retail Store Opening
John’s Crazy Socks launched online in 2016, and has shipped half a million to date
Gov. Little celebrates U.S. Supreme Court’s decision upholding protections for women’s sports
Boise, Idaho – Governor Brad Little commented today on the U.S. Supreme Court’s decision in Little v. Hecox. The ruling upholds Idaho’s ban on men participating in women’s sports. “Idaho was the very first state to ban men from participating in women’s sports with the passage of the Fairness
Northwest Earth and Space Science Pathways Project Celebrates Student Innovation Through ROADS from Earth to Venus National Challenge
The Northwest Earth and Space Science Pathways (NESSP) project recently concluded its 2025–2026 ROADS (Rover Observation And Discoveries in Space) from Earth
Gov. Laura Kelly surveys landscape as she exits government service, points to unfinished business
Term-limited Gov. Laura Kelly celebrates work on priorities of economic development, fiscal stewardship and investment in early-childhood development.
Genesis Celebrates Science Behind Baking
(Southeastern IN) – Genesis: Pathways to Success is celebrating the successful conclusion of Science Behind Baking Camp, an engaging A Summer of STREAM experience that combined nutrition education, teamwork, and hands-on baking. Throughout the camp, […]
Movies, books, art and music to explore as America turns 250
As America celebrates 250 years, we size up how it’s been portrayed in, and has shaped, what we watch, listen to and read.
Hollywood celebrates Mel Brooks' 100th birthday
Mel Brooks' 100th birthday is being celebrated by friends, fans, and the whole of Hollywood.
VIA Women’s Health Collective celebrates grand opening
By Megan Dial VIA Women’s Health Collective, 17300 Westfield Blvd., Suite 330, celebrated its grand opening June 18 with the Westfield mayor, Westfield Chamber of Commerce and other community supporters. Dr. Taylor Hahn said she founded VIA Women’s Health Collective to support women in every s
UAPB School of Business and Management celebrates class of 2026
The School of Business and Management (SBM) at the University of Arkansas at Pine Bluff recognized the achievements of its graduating Class of 2026 during its annual Graduates Banquet recently at the STEM Conference Center. The event, coordinated by Cynthia Sims, SBM project/program specialist, brought together students, faculty, administrators, alumni, family members and supporters to […]
Team USA Basketball Showcase celebrates youth sports
The Team USA Basketball Showcase tipped off on Saturday featuring community, camaraderie, and a continuing commitment to youth sports.
San Antonio Pride festival celebrates LGBTQ+ community, raises money for local nonprofits
Thousands of people were expected at Crockett Park on Saturday for the Pride Bigger Than Texas Festival, an eight-hour celebration of LGBTQ+ history, resilience and community support.
‘This is a safe place.' Angel City Games celebrates adaptive sports
The three-day event at El Camino College is bringing together people of all ages and skill levels. Lolita Lopez reports for the NBC4 News at 4 p.m. on Friday, June 26, 2026.
Business Honor Roll picnic celebrates community support
The Business Relations Committee at MyMichigan Medical Center Alpena recently welcomed local professionals and industry leaders to a Business Honor Roll Appreciation Picnic hosted by Alpena Agency in their downtown location. Established in 1994, the Business Honor Roll brings together local companies and corporations interested in strengthening health care for our region. Through annual contributions […]
Local business celebrates 10 year anniversary with $5,000 in cash prizes up for grabs
It is a celebratory feat for any small business to successfully reach 10 years in operation.To mark their 10 year anniversary, Escape It Grandview will be host
Mel Brooks Is Turning 100! His 1 Tip for Longevity, a Healthy Life
The comedy legend and father of satire celebrates his big 100th birthday on June 28.
Uncle Julio's Fort Worth Celebrates Grand Re-Opening Weekend with Renovated Restaurant, Expanded Patio, Live Entertainment and Exclusive Offers
Uncle Julio's is welcoming guests back to its newly refreshed Fort Worth location with a three-day Grand Re-Opening celebration packed with exclusive offers,...
Lorain flower shop celebrating 75 years as part of International Festival and Bazaar
Lorain has seen businesses come and go, but at least one has stood the test of time. Zelek Flower Shop celebrates 75 years this summer.
Small Business Central to American Prosperity Celebration
House Small Business Committee celebrates small businesses as key to American prosperity ahead of nation's 250th anniversary. Learn why Main Street matters.
Introducing: Breguet Celebrates the 225th Anniversary of the Tourbillon with Four New Releases, And the Return of a Collector Favorite (Live Pics)
A revived and revised version of the Roth-designed caliber 558.1 movement (significantly improved) headlines four watches to celebrate the patent date of one of Abraham-Louis Breguet's most notable achievements.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Governor Mills Celebrates Groundbreaking for Youth Mental Health Treatment Facility in Saco
Saco, MAINE-- Governor Janet Mills today participated in a groundbreaking ceremony for Sweetser's new youth psychiatric residential treatment facility. Governor Mills and the Legislature secured more than $5 million to help build the treatment facility.
Brooks’ House of Bar-B-Q Celebrates 75 Years of Service
Brooks’ Bar-B-Q is celebrating seventy-five years of being in business.
PANAM SPORTS CELEBRATES OLYMPIC DAY WITH ITS MIAMI COMMUNITY
On International Olympic Day, Panam Sports brought the spirit of the Olympic […]
PENN Entertainment Celebrates Grand Opening of Hollywood Casino and Hotel Aurora
PENN Entertainment, Inc. (Nasdaq: PENN) (“PENN” or the “Company”) today celebrates the grand opening of Hollywood Casino and Hotel Aurora, the all-new, $360 ...
PENN Entertainment Celebrates Grand Opening of Hollywood Casino and Hotel Aurora
WYOMISSING, Pa. & AURORA, Ill., June 24, 2026--PENN Entertainment, Inc. (Nasdaq: PENN) ("PENN" or the "Company") today celebrates the grand opening of Hollywood Casino and Hotel Aurora, the all-new, $360 million state-of-the-art casino and hotel. PENN’s latest land-based property replaces the former riverboat property that operated on the Illinois shores of the Fox River since 1993.
Chevalier celebrates projected New York primary win
Democratic candidate Darializa Avila Chevalier celebrated her projected win in the Democratic primary in New York's 13th District after defeating incumbent Rep. Adriano Espaillat. Chevalier was joined by New York Mayor Zohran Mamdani who she was endorsed by.
Rooted in History: Peoria’s Hoerr Nursery celebrates century in business
The Peoria County Board recently recognized Hoerr Nursery for its century-long run and how the family-owned company has grown through the generations.
Heritage Days celebrates America’s 250th
The Mount Vernon-Lisbon Community Development Group and Heritage Days Committee invite residents and visitors to celebrate Heritage Days 2026 with two days of family fun, live entertainment and community traditions honoring America's 250th anniversary on July 10-11.
Film Independent Spirit Awards to Present Robert Redford Environmental Vision Award
The new award in the late actor's honor "celebrates environmental fiction film and television projects taking an entertainment-first approach"
Brunch Con Familia celebrates creativity, entrepreneurship and family with new entertainment partnership
Brunch Con Familia launched an entertainment partnership centered on Soccer Gods, artist opportunities, entrepreneurship and family-led creativity.
SJP celebrates her and Matthew Broderick's daughters' 17th birthday with never-before-seen photos
'Sex and the City' star Sarah Jessica Parker celebrates the 17th birthday of her and Matthew Broderick's twin daughters, Tabitha and Loretta, with never-before-seen photos.
What 70 Years In Business Has Taught Us About Leadership
This year, 84 Lumber celebrates 70 years in business. For a privately held company, reaching that milestone is rare.
Mesquite Entertainment celebrates 4th of July weekend with free poolside concerts, BBQ favorites and more
(Sponsored) Mesquite Entertainment invites guests to celebrate Independence Day weekend with free live entertainment, festive food and beverage offerings, and summer fun at the CasaBlanca Resort & Casino and Virgin
Star City Golf Club celebrates first Father’s Day in business
Dads across our hometowns celebrated Father’s Day on Sunday, whether relaxing on the couch, splashing in the pool or bringing out the golf clubs. That’s what one Roanoke business opened its doors for.
'Our hero': Savannah Guthrie celebrates husband in Father's Day post
"Today" show host Savannah Guthrie shone the Father's Day love light on her husband Mike Feldman, calling her supportive spouse of 12 years the family's "hero."
Science Museum Oklahoma celebrates Father's Day with free admission for dads
The Science Musuem of
Pai family patriarch celebrates generations involved in surf shop business, Surf City community
Aaron Pai bought Huntington Surf and Sport nearly 50 years ago, and has created a legacy of “aloha” with his own growing family, and the surfing “ohana” across Huntington Beach and the world.
How the WNBA went from survival mode to a billion-dollar future
As the WNBA celebrates its 30th anniversary, the once-fledgling league has evolved from its 1997 launch into a global fixture in women’s sports.
Beyond the World Cup... 5️⃣ stories shaping Sunday
Spanish football is experiencing a day of high emotion, with the offices and the pitch sharing the spotlight.While the Costa del Sol celebrates a historic return to the top flight after an agonizing j...
Vidler’s celebrates 96 years of business
BUFFALO, N.Y. (WIVB) — A Western New York staple celebrated 96 years in business Saturday — Vidler’s variety store is nearing the century mark of serving East Aurora and visitors …
6-woman team celebrates opening of expanded Tazewell County business
A design shop opened an expanded storefront in Morton on Saturday, hosting an open house to showcase the new space and its six-woman team.
Juneteenth Cultural Festival celebrates community but also highlights Black-owned businesses
The event, at the LIRR station, is advertised as "Long Island's biggest Juneteenth cultural celebration," drew hundreds of attendees and about 60 businesses.
Le'Stuff Antique Mall Celebrates 25 Years In Business ~ The Greatest Treasure Is The Owners
Le'Stuff Antique Mall Celebrates 25 Years in Hillsboro, Oregon. The amazing store is something special and it's owners are even more so.