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Manchester United and Liverpool battling for Borussia Dortmund star
Manchester United and Liverpool are both considering a move for Borussia Dortmund midfielder Felix Nmecha, according to TEAMtalk.The report suggests that Manchester United have made contact as they as...
ARK Invest Bets One Business Can Lift Tesla Stock to $4,400
ARK Invest’s open-source model values Tesla at about $4,400 per share in 2031, with robotaxis at 80% of enterprise value.
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
STEAM dreams: Children discover science, creativity and hands-on fun as iMAGINE Festival fills Uptown Greenwood
Giant bubbles floated through the air, robots whirred to life and children became scientists, engineers and artists for a day Saturday as the iMAGINE STEAM Festival took over a large
Chig Okonkwo leads team in receiving
Chig Okonkwo led the club in both receptions and receiving yards during Washington's Week 6 loss to the 49ers.
Here's how Central District Health plans to spend over $200k on the Treasure Valley's growing rat population
Here's how Central District Health plans to spend over $200k on the Treasure Valley's growing rat population
‘He’s solid, has integrity and character’: Longtime TX GOP judge backs Talarico for Senate
Advocate Illinois Masonic Medical Center cafeteria closes after failed health inspection
Proposed New Visa for Home Health Aides and Nursing Assistants: What Healthcare Staffing Companies Need to Know
A new policy proposal published by the Brookings Institution recommends creating a temporary work visa that would let US employers sponsor foreign home health aides, personal care aides, and nursing assistants to help ease a growing shortage of caregivers. The September 29 proposal, authored by Brookings scholar Tara Watson through the Hamilton Project, would create an “H-1D” visa category built specifically for the direct-care workforce, launching as a pilot program of 30,000 visas per year. It would require employers to pay wages near the top of the local market, guarantee workers a minimum number of weekly hours, and contemplate a potential pathway to permanent residence after six years, although implementing that pathway would require additional changes to immigration law. The H-1D is only a proposal at this point. No H-1D legislation has been enacted, and employers cannot currently sponsor workers under this proposed classification. But if the idea gains traction, healthcare staffing companies could find themselves with both a significant recruiting opportunity and a new set of compliance obligations. This Insight walks through the proposal’s general immigration and employment requirements, then turns to the specific opportunities and challenges it could create for staffing firms.
Inglewood small business builds knitting community, garners national attention
Three Free Agent Relievers Who Could Fix Tigers’ Bullpen
The free agent relievers class is both strong and deep this off-season. That's great news for a Detroit Tigers team that struggled in high-leverage situations late in games, blowing 68 leads en route to a disappointing fourth-place finish in the American League Central. Those 68 blown leads are both a franchise and Major League Baseball …
Inglewood business brings knitters together, garners national attention
Advanced materials firm founded by LANL veteran moves into Nambé facility
Discovery 2 Scale is working with AI to develop new materials for national security applications and using robotics to test and manufacture them.
AI-generated political ads are showing up on TV screens, experts say they are getting harder to spot
Vandals hit NYC subway OMNY readers in apparent political protest
NEW YORK — Cops are looking for a group of vandals who took a drill to a bank of One Metro New York, or OMNY, readers at a Brooklyn subway station, apparently as a political protest. The subway sabota...
Toppenish School District receives $7.5 million federal grant to expand mental health services for students
The BriefThe Toppenish School District has been awarded up to $7.5 million through Project AWARE (Advancing Wellness and Resiliency in Education), a federal grant administered by the Substance Abuse and Mental Health Services Administration (SAMHSA).The grant will provide up to $1.5 million annually over five years to expand mental health services, strengthen substance use prevention and intervention, and improve access to support for students.District officials say the funding will help address identified gaps in services, particularly drug and alcohol counseling at the high school level, and will allow the district to build capacity for long-term mental health support.TOPPENISH, WASHINGTON — The Toppenish School District has been awarded up to $7.5 million through Project AWARE (Advancing Wellness and Resiliency in Education), a federal grant administered by the Substance Abuse and Mental Health Services Administration (SAMHSA), to expand mental health services and substance use prevention for students.District officials said access to mental health resources has been limited, making it difficult for some students and families to get the support they need. The federal Project AWARE grant will help address those challenges by bringing schools and local healthcare providers together to better support students.The grant will provide up to $1.5 million annually over five years to expand mental health services, strengthen substance use prevention and intervention, and improve access to support for Toppenish students. Deputy Superintendent Dr. Jeff Camero said the district is focused on coordinating with service providers in the area to work as a unified team."We made the awareness with the grant. But looking at all the service providers in the area and how can we all together work as a team?" Camero said.Camero said the district wants to use those resources to reach students earlier and provide more support for those struggling with their mental health. The district plans to address a range of mental health challenges, from anxiety and depression to youth suicide risk. Camero emphasized the importance of supporting students in grades eight through twelve, where suicide rates are a particular concern."Making sure from anxiety to depression, making sure that we can help support our students at those levels, but also the youth suicide risk, looking at that as a top in this area, in our grades, you know, eight, for example, eight through 12, looking at suicide rate and looking at how whether we look at the ACES or whatever program we're looking at, that's federal, how that connects and how we can better serve our students with this extra funding," Camero said.The funding will allow the district to bring in additional staff, including mental health and substance use specialists, to work directly with students and connect families with community resources. The district is already posting positions, including a director role, with additional positions expected to follow.District officials are also thinking beyond the grant's five-year timeline. Brittany Kaple, Director of Public Relations for the Toppenish School District, said the intent is to build capacity and establish connections that will sustain mental health services even after the grant funding ends."We do have the director position already posted, with some of our other positions following really close behind that. But the intent is to, you know, it's a five-year grant, so those positions would be funded for that five years. But there's also the intent to build capacity and make those connections so that at the end of the grant, when that money, you know, if that money is not renewed," Kaple said.As student mental health needs continue to evolve, access to drug and alcohol counseling has become an important priority for the district. Kaple said teachers and staff have been raising concerns about the need for more support, especially at the high school level."And that was something that was also an identified need by our high school staff when the superintendent met with them last school year. They said that that was a really great need, something that they felt was a gap in services that we were providing for our students. And so this is going to be one way to help support that need," Kaple said.The Toppenish School District says its goal is to ensure students and families have access to the support they need, both now and in the years ahead. Additional positions, including drug and alcohol counselors and family engagement specialists, are expected to be posted in the coming weeks. News Sunnyside City Council navigates 2027 budget planning Monique Garcia News "Dancing with the Stars" champion J.R. Martinez shares message of resilience during Central Washington visit Tyler Wargo News Toppenish, Mattawa educators honored at state Educator of the Year Awards Erin Wencl News Kennewick educator named 2027 Washington Teacher of the Year Erin Wencl News Voters to decide the next Yakima County Sheriff Monique Garcia COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Ex-GOP Kansas governor compares Trump rally to ‘freak show’ while backing Democrat in Senate race
Commanders vs. 49ers live updates, inactives, where to watch: Mike Evans, Stefon Diggs active for Monday Night Football
Warren stumps for Haaland in ABQ as both pitch New Mexico as affordability solution for Dems
U.S. Sen. Elizabeth Warren joined Deb Haaland’s campaign in Albuquerque on Monday to talk about New Mexico’s universal childcare program. The program launched last November and is the first of its kind in the country to offer free statewide childcare for working families without income limits or copayments. As Americans are becoming more and more […]
Martin Short mercilessly roasts Conan O’Brien: ‘You look like Ed Sheeran in a funhouse mirror’
Martin Short mercilessly roasted Conan O’Brien on his podcast for minutes on end, calling him ‘Carrot Bottom,’ ‘Ed Sheeran in a funhouse mirror,’ and ‘a human surrender.’
TENNESSEE VOLS BASKETBALL: AP poll slots Vols at No. 8
The University of Tennessee men's basketball team is in the preseason top 10 of both major polls, as released Monday afternoon.
‘Euphoria’ star Hunter Schafer underwent bottom surgery
NEW YORK — “Euphoria” star Hunter Schafer revealed in an interview published Monday that she recently underwent a genital reconstructive procedure to align her identity and gender. “I just had
Fairburn Road bridge project raises concerns for nearby South Fulton businesses
Dan Campbell Reveals Surprising Possibility for Lions Offensive Line
The return of Cade Mays could create an unexpected opportunity for Juice Scruggs. Dan Campbell is considering ways to keep both offensive linemen involved as Detroit prepares for Green Bay.
Texas Democratic candidate for governor sues to review emails between Elon Musk and Greg Abbott
State Rep. Gina Hinojosa alleged in her lawsuit that Gov. Greg Abbott is “unlawfully withholding communications” between his office and tech CEO Elon Musk.
Opinion | US-China AI talks must ensure safety of both tech and business
A hotline and an ad hoc dialogue are not enough. Safety concerns are growing for both the technology and leveraged tech companies.
Lakers waive Dalton Knecht ahead of season opener, roster deadline after failing to find trade partner
Republicans pull funding in Ohio’s 1st District as race shifts toward Democrats
The district was once considered one of the most competitive in the country, with both parties viewing it as key to maintaining control of the House.
Japan launches spacecraft to Mars' moon in mission to bring back soil samples
Five of the world's space agencies have joined forces for the five-year mission that will attempt to land a robotic prospector plus a rover on Phobos, the larger of Mars' two moons.
Cowboys' Stephen Jones 'absolutely' supports Brian Schottenheimer after another miserable showing, 2-4 start
President Trump in Macon Saturday, as political heavyweights flood Georgia before Nov. 3
Obama to stump Oct. 28 for Ossoff, Bottoms; Harris to keynote Fulton fundraiser Oct. 30 with Ossoff.
ROI-NJ celebrates New Jersey family businesses at inaugural Family Business of the Year Awards
ROI-NJ celebrated 16 New Jersey family businesses at its inaugural awards, naming MSI Plumbing & Remodeling and NRS Inc. the 2026 winners.
Men's college basketball rankings: Preseason USA TODAY Sports Coaches Poll, AP Top 25
The USA TODAY Sports Coaches Poll and AP Top 25 both unveiled their respective preseason rankings for the 2026-27 men's college basketball season.
NBA Predictions 2026-27: Who wins MVP? Rookie of the Year? Our experts make their awards picks
Oregon State U. Put Its Chips on Computer Science. Then the Bottom Fell Out.
The university’s $19-million loss shows the risk of betting enrollment on job trends.
Early Black Friday Deals Already Live on Square Enix Games, Slashing Final Fantasy 7 Rebirth and More Down to Brand-New All-Time Lows at Amazon and Best Buy
Amazon and Best Buy have both dropped early Black Friday sales on select Square Enix games that features big price cuts on Final Fantasy 7 Remake Intergrade, Final Fantasy 7 Rebirth, and loads more.
Donald Trump signs executive order creating NIH task force as Melania unveils 'new standard for women's health in America'
Super El Niño forces dramatic color shift in the Pacific — as record-breaking temperatures threaten marine life
Pakistan suspends Iran border trade, amid violence on both sides
Islamabad cites security concerns, while Tehran points to technical issues as Pakistan mediates between Iran and the US.
RWS Global sponsors new IAAPA Foundation Entertainment Task Force Scholarship
RWS Global is proud to sponsor the new IAAPA Foundation Entertainment Task Force Scholarship, supporting the next generation of talent shaping live entertainment. The program recognizes both sides …
Is death a black hole with no escape? Science and religion draw very different conclusions
Inside College Football Playoff's 24-team expansion: What to know about the new format, schedule and fallout
PS5 "bullet ballet" game Saros gets a big update to make it both easier and harder
PS5 shooter Saros gets a big update. You can modify the game to make it both easier and harder now, and slow time to give yourself more time to think.
Supreme Court to decide legality of federal ban on distilling liquor at home
200 supporters rally for Hinojosa as Abbott is expected to campaign in Houston-area this week
Democratic candidate for governor Gina Hinojosa rallies with supporters the day before the state of early voting. The race has tightened in recent weeks. Governor Greg Abbott is also expected to spend time in the southeast Texas this week.
How Boston Dynamics is turning robots into a real business
CFO Amanda McMaster explains how Spot found paying customers and why Hyundai's backing could help Atlas scale.
Legacy Berkeley businesses and orgs that have lasted decades honored by city
Berkeley Ace Hardware and Berkeley Humane (both est. 1895) are among the hundreds of organizations 25 years or older celebrated.
Data or privacy? Businesses can have both, MIT Sloan research finds
Data regulation doesn’t necessarily cause economic harm. Markets — and consumers — can still derive economic benefits from data collection when it’s tempered by reasonable privacy guardrails.