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Philadelphia Eagles: Promote RB With Over 1,600 Career Yards
Injuries continue to plague the Philadelphia Eagles‘ running back room. Saquon Barkley suffered a hamstring injury and is reportedly week-to-week, meaning he could miss one game to multiple weeks. Additionally, Tank Bigsby, the second option, recently underwent core muscle surgery, prompting the Eagles to place him on injured reserve, hoping he misses six weeks or […] The post Philadelphia Eagles: Promote RB With Over 1,600 Career Yards appeared first on Gridiron Heroics.
‘He Has a Bigger Problem,’ ‘Embarrassed The Business’ — NFL Legend Terrell Owens Has No Sympathy For Tony Romo After Controversial CBS Exit
Terrell Owens has little sympathy for Tony Romo following the former Dallas Cowboys quarterback’s sudden departure from CBS Sports. The network announced on Friday that it had mutually agreed to part ways with Romo after nine years in the broadcast booth, bringing an unexpected end to one of the biggest analyst careers in recent NFL history.
Travis Barker in hospital, reveals health update in new photos
Travis Barker is giving fans a health update, with the Blink-182 drummer sharing new photos from an apparent hospitalization.
Senator Yaw leads push to stay skill games seizure into 2027
Harrisburg, Pa. — Skill game machines in bars, clubs, and shops across the state could stay safe from police seizure until February if four state lawmakers, primarily Sen. Gene Yaw,
Travis Barker in hospital, reveals health update in new photos
For Travis Barker, love is the best medicine.
Spotify Camp Nou to host Pedro’s farewell following retirement announcement
FC Barcelona icon Pedro Rodriguez has announced his retirement from professional football at the age of 39, bringing an end to a 20-year career. The former Barcelona forward, who enjoyed the most succ...
Africa embraces ‘Go to Work on an Egg’ to boost maternal health and nutrition
The sun is barely up when villagers start queuing for eggs at the metal gate of Shamim Haried’s home.
Critical funding gap threatens health response in Yemen
The World Health Organization (WHO) warned that significantly more resources are required to scale up its response in Yemen amid escalating conflict and rising needs.
I-194 won’t stop the political ads
Montanans are being bombarded with television and other political ads in this year’s congressional races. Voters should understand an important limitation of ballot initiative I-194: it would not stop much
Galveston's Ball High School holds an incredible Texas sports record
Bar trivia warriors, take note of the purple and gold.
Gossip: Barcelona leaning towards selling Frenkie de Jong
The club have an overbooking of midfielders.
I test the best TVs and soundbars. Here are the 19 best Amazon Prime Day TV deals
Our tech reviewer and TV tester has picked his favorite TV, soundbar and streaming device sales that arrived for this year’s October Prime Day sale.
IMF chief warns energy shock, public debt and AI boom threaten global growth
Kristalina Georgieva’s warning comes as Brent crude rises above $101 a barrel
WHO releases first global guidelines on child obesity as cases surge
Child and adolescent obesity has quadrupled since 1990, rising from two per cent to around eight per cent of youngsters in the five-to-19 age group, according to the UN’s World Health Organization (WHO).
Sitcom king Chuck Lorre says Roseanne Barr ‘fundamentally hated’ her show’s writers: ‘It was malice’
Lorre, who created hits like “Two and a Half Men” and “The Big Bang Theory,” got his start writing for the tempestuous stand-up on “Roseanne.”
Chuck Lorre says Roseanne Barr ‘fundamentally hated’ her show’s writers: ‘It was malice’
Chuck Lorre, who got his start writing on ‘Roseanne’ in the ’80s, says Roseanne Barr ‘fundamentally hated’ her sitcom’s writers, because as a stand-up, ‘she made herself a superstar based on her words.’
HSBC plans sweeping job cuts across UK wealth business in AI push
Bank is consulting with staff on reductions in roles affecting managers, specialists and financial advisers
Skydance now runs two of Hollywood’s legacy film studios. A look at the new company, by the numbers
David Ellison’s Paramount Skydance has completed its $81 billion acquisition of Warner Bros. Discovery, bringing two of Hollywood’s most storied legacy film studios under one mammoth media and entertainment conglomerate named Skydance. Now, Skydance must decide how to make the most out of a trove of entertainment assets, including the HBO Max and Paramount+ video streaming services, a film library that includes “Star Trek,” “Barbie,” “Top Gun,” “Harry Potter,” and “Superman,” and two major news organizations, CNN and CBS News. Here’s a look at the new company, by the numbers.
Eagles Must Pursue RB Options After Saquon Barkley and Tank Bigsby Injuries
The Philadelphia Eagles need to pursue another running back after their latest injuries.
Health Brief: Medical devices join Trump’s tariff bargain
Plus: Trump administration turns up the heat on price transparency enforcement
Former CIA official accused of stealing $40M in gold bars pleads guilty
A former senior CIA official pleaded guilty on Tuesday in Virginia to a charge that he abused his position and government funds to enrich himself by acquiring Florida real estate and hundreds of gold bars worth over $40 million, according to court records.
What a way to reject a lawsuit
The company managing Dolly Parton’s estate alleges the late singer’s nephew, Bryan Seaver, used barbed wire and yellow caution tape to help keep a process server at bay, according to Rolling Stone.
Coordinated care supports mother through cancer and pregnancy
When pregnancy complicated Deziree Ibarra’s treatment for stage 4 lung cancer, specialists across UT Health San Antonio worked together to balance cancer treatment with the safe development and delivery of her baby.
Eagles Star RB Saquon Barkley Receives Major Injury Update
Philadelphia Eagles star running back Saquon Barkley will miss some time with a hamstring injury.
Claude launches Google Docs, Sheets, and Slides integration with sidebar and more
If Gemini isn’t quite your cup of tea, Anthropic’s Claude now supports sidebar integration with Google Docs, Sheets, and Slides....
How Russia and the world are responding to a possible case of pneumonic plague after lab worker death
The World Health Organization says a possible case of pneumonic plague in Russia presents a “very low” risk outside the country as investigators look into what caused the death of a lab employee there last week.
Biden-era FBI’s ‘Nixonian’ Trump family surveillance draws scrutiny from unlikely corner
Julian Epstein, a former top Democratic official, compared the FBI's tracking of Melania Trump, Barron Trump and Susie Wiles to Nixonian tactics.
Jadan Baugh still in USA TODAY Sports' Heisman Trophy race, but barely
Despite a disappointing performance against Missouri in Week 5, Florida football's star running back Jadan Baugh remains in the Heisman Trophy hunt.
Health Data Interoperability Still Faces Persistent Barriers
A CRS report says U.S. health data interoperability still faces persistent barriers. Read about the challenges and implications for connected care today.
Gov. Braun appoints new public access counselor after complaints mount
Former Bartholomew County Circuit Court Magistrate Judge Brittney Long has been named Indiana’s public access counselor, replacing attorney Jennifer Ruby, whose 18-month tenure in that job was marked by long
Music-themed District Sound Lounge is coming to Wyandotte
The new bar is connected to live music venue District 142 and will have a full bar, food, acoustic performers and vinyl DJs.
Political newcomers vying for 51st District state House seat
The 51st District includes all or part of Barrington, Kildeer, Deer Park, Long Grove, Vernon Hills, Lake Zurich, Hawthorn Woods, Inverness, Palatine, Hoffman Estates, and Rolling Meadows.
Becker’s Hospital Review Names RWJBarnabas Health and Rutgers Cancer Institute to 2026 “100 Hospitals and Health Systems
RWJBarnabas Health, together with Rutgers Cancer Institute, the state's only National Cancer Institute-designated Comprehensive Cancer Center, has been named to Becker’s Hospital Review’s 100 Hospitals and Health Systems with Great Oncology Programs list for 2026, for the fourth consecutive year.
Beach advisory issued in Miami-Dade for elevated bacteria levels
The Florida Department of Health issued a health advisory for a Key Biscayne beach due to elevated levels of bacteria in nearby waters.
Block Club Chicago’s Free South Side Health & Wellness Fest Is Coming to Chatham
Join Block Club and community partners on Nov. 7 for activities and resources to help address health equity gaps. Join a fun run with Joabe Barbosa, get a free meal and more.
Baltimore’s small business owners want the city to codify more protections
Zehbras CrossFit is the thriving, Black-owned, affordable, and accessible fitness space owner and CrossFit coach Jeanelle Spencer long wanted to bring to Baltimore’s Black Butterfly. On any given weekday afternoon, barbells slam onto rubber mats as Spencer’s neighbors in Waverly cycle through burpees, pull-ups, squats, and more in the small gym at 3302 Greenmount Avenue. […]
Saquon Barkley Injury Update: Eagles RB’s Hamstring Timeline Revealed
Saquon Barkley suffered a hamstring injury against the Los Angeles Rams, and it could be a few weeks before we see the superstar running back on the field. Originally entering the league as the second-overall pick in the 2018 NFL Draft, the Penn State product hit the ground running, recording 1,307 yards and 11 touchdowns …
OVG To Operate, Book Riverview Health Arena in Noblesville, Ind.
The City of Noblesville, Indiana, has announced that Oak View Group will operate and book the 3,400-seat Riverview Health Arena at Innovation Mile. The arena
On the barricades with wheelie bins and shopping trolleys: Paris students rage at politicians and police
Unprecedented protests that began in low-income banlieue are turning ugly, with investigations under way into police brutality
'Nobody Cares' review: Laura Benanti sings for laughs
Tony-winner Laura Benanti brought her solo comedy cabaret 'Nobody Cares" to the Wallis and the show is now headed to South Coast Repertory.
Raphinha signs new contract at Barcelona until 2030
Raphinha has signed a new contract with Barcelona until the summer of 2030.The 29-year-old’s current deal runs until 2028, having penned a new contract with the club last year.The renewal is effecti...
Manchester United remain interested in Barcelona outcast
The new season has not been kind to Alejandro Balde, who has quickly slumped from a regular starter to a backup option under Hansi Flick.Since pre-season, the manager has made it clear that he needs t...
Mental health stigma may deter treatment seeking in Japan
A UC Riverside-led study of mental health stigma in Japan has found a striking gap between the need for treatment and people's willingness to seek it, with high levels of social distancing toward people with mental illness serving as a potential barrier.
The politics of losing sleep
There is still a class divide when it comes to work that tramples over your body clock
Trump says he will stop using US taxpayer funds for ads
The ads, which tout Trump and his policies, could have violated US laws barring public government funds being spent on political advertising.
'Stop playing politics': Ginther, Council trade barbs over $2.5M Barack Center repairs
A fight over $2.5 million in repairs to a tornado-damaged Southside community center has escalated into a public political clash between Columbus Mayor Andrew G
Columbus Councilmembers say mayor playing politics over damaged rec center
Columbus City Councilmember Nancy Day-Achauer is accusing Mayor Andrew Ginther of using Barack Recreation Center as a "political prop" after it was damaged by a tornado in August.
Cincinnati nuisance business rules for late-night bars face fierce opposition
A proposed crackdown on Cincinnati’s so-called nuisance businesses has put City Hall at odds with some late-night bar and nightclub owners.
Former ASU swimmer Grant House helped reshape college sports
Five years after becoming the lead plaintiff in House v. NCAA, former Arizona State swimmer Grant House reflects on the lawsuit that helped reshape college athletics, the leadership lessons he learned and his continued fight for athletes’ voices and collective bargaining with the Protect College Sports Act making its way through Congress.
Marfan Foundation Convenes Global Scientists in Barcelona to Advance Research on Marfan, Loeys-Dietz, VEDS and Related Conditions
The Marfan Foundation brings scientists from 23 countries to Barcelona to share research that may lead to new treatments and better quality of life for people with Marfan, Loeys-Dietz and VEDS.
Five fall business updates for Liberty Hill
New businesses are moving into Liberty Hill, including Crazy Falafels, Cashmere Bar + Board, Gracie Barra, QuesaLab and Milano Nail Spa.
Judge allows student IDs as fallback for NH voters
A federal judge ruled New Hampshire election officials may consider student IDs as voter identity evidence when no other ID is available, despite a law barring ...
Barkov Timeline Throws Cold Water on Dylan Larkin Trade
Barkov's 10-to-12-week timeline gives Florida only temporary cap relief, cooling the Dylan Larkin trade talk. #RedWings
How a controversial camera system is monitoring mental health patients
The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment
Saquon Barkley injury update is encouraging news for Eagles
The Philadelphia Eagles may not be forced to compete without their star running back for long.
Amy Coney Barrett calls oil companies’ arguments ‘slippery’
Supreme Court Justice Amy Coney Barrett criticized fossil fuel companies as “a little slippery” in oral arguments over a lawsuit in which oil majors claim that federal law blocks states from suing them for climate change-related damages. Her comment came in arguments Monday in the case Suncor Energy v. County Commissioners of Boulder County, which […]
The business of women's sports is booming—a viral bar that brings in $1M a year wants to take advantage
As women's sports enjoy record viewership, The Sports Bra — a Portland, Oregon, bar that only plays women's sports on TV — is rolling out national franchise plans.
Saquon Barkley injury update: Latest on Eagles star running back
Saquon Barkley has undergone testing on his injured hamstring as the Eagles prepare to face Jacksonville in London
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree
Mark E. Manigan, President and Chief Executive Officer of RWJBarnabas Health, the largest, most comprehensive academic health system in New Jersey, has been named a 2026 Executive Excellence honoree by NJBIZ, recognizing his leadership and impact on New Jersey’s health care landscape. Mr. Manigan and the other honorees will be recognized by NJBIZ at an awards ceremony taking place today.
Spanish PM Pedro Sánchez looks for political lifeline in snap election
Embattled Socialist leader aims to capitalise on housing crisis to remain in power
Barcelona superstar set for salary raise as per prior agreement
Lamine Yamal’s start to the new season has been astonishing, and the player is operating at a level that any normal teenager should not even be able to dream of.He is, at this point, one of the best...
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree
Mark E. Manigan, President and Chief Executive Officer of RWJBarnabas Health, the largest, most comprehensive academic health system in New Jersey, has been named a 2026 Executive Excellence honoree by NJBIZ, recognizing his leadership and impact on New Jersey’s health care landscape.
Weaner Pig Breakeven at $22.46, Up $12.25 From Last Week
When you consider that today’s purchased weaner would be sold in March 2027 using April 2027 futures, the weaner breakeven was $22.46, up $12.25 for the week, and $0.57 below the average cash price for the week of $23.03.
More than a prescription: Removing barriers so patients can get back to living
See how integrated specialty pharmacy support helped one patient overcome treatment barriers and get back to the moments that matter most.
Some mental health providers hoping to serve Lane County's Oregon Health Plan members say they’re facing barriers
Aspire is one of a few healthcare providers in Lane County that told KLCC they want to – but haven’t been able to – get a contract with Lane County's Medicaid insurer Trillium. That’s left Aspire without access to its target population, and other providers considering scaling back their services.
George L․ Kumar: Six Biology Breakthroughs Stockholm Missed
George L․ Kumar: Six Biology Breakthroughs Stockholm Missed / Ben Barres, cancer, Colin MacLeod, Ernest McCulloch, George L. Kumar, James Till, Kavli Prize,
Qalo SL-1 review: A barebones smart band that's priced like a flagship
Qalo’s first screenless tracker is too expensive for what it is.
Ground Zero Blues Club
A Labor of Love for its Three Managers It is no mystery why Ground Zero Blues Club (GZBC) is one of the most famous blues clubs in the country. It is a genuine juke joint where customers are treated to great live music along with genuine hospitality serving up Southern food favorites like barbecue […]
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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