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18 Sports Commentary – the first day of the school year
ELMIRA, N.Y. (WETM) – It’s time for another special 18 Sport Commentary. On this edition, we discuss the very first day of school in the New York region of The Southern Tier. The first day of school symbolizes much more than just being the first day to go back to the classroom. It’s symbolic of […]
D-backs @ Royals discussion
Today’s Lineups DIAMONDBACKS ROYALS Lars Nootbaar – DH Carter Jensen – C Ketel Marte – 2B Bobby Witt – SS Gabriel Moreno – C Vinnie Pasquantino – 1B Geraldo Perdomo – SS Salvador Perez – DH Corbin Carroll – RF Michael Massey – 2B Nolan Arenado – 3B Nick Loftin – 3B Tommy Troy – […]
Why was Corbin Carroll suddenly scratched from the Diamondbacks’ lineup?
KANSAS CITY – In a sudden move before Tuesday night’s matchup for the Arizona Diamondbacks in Kansas City against the Royals, Corbin Carroll has been scratched from the lineup. Jun 10, 2026; Miami, Florida, USA; Arizona right fielder Carroll (7) rounds past second base against the Miami Marlins during the first inning at loanDepot Park.
ABC denies 'inaccurate' report 'Jimmy Kimmel Live!' will end in 2027
Amid speculation about Jimmy Kimmel's late-night tenure coming to an end, ABC is pushing back. On Sept. 8, Page Six reported that this season of "Jimmy Kimmel Live," will be
Council backs L.A. fast-food worker scheduling protections as businesses complain of tight margins
The Los Angeles City Council on Tuesday approved an ordinance to extend Fair Work Week scheduling rules to fast-food workers, adding predictable shifts and paid labor-rights training for tens of thous...
Bills Announce Exciting Josh Allen News Before Season Opener
The Buffalo Bills announced that quarterback Josh Allen is among the six players picked as captains for the 2026 season. The post Bills Announce Exciting Josh Allen News Before Season Opener appeared first on HEAVY.
SpaceX's recovered Starship 40 will take months to get back to Texas
SpaceX's powerful rocket traveled thousands of miles from Texas to the Indian Ocean in around 65 minutes. It'll take a lot of time and effort to get it home.
Broncos host 2 linebackers and 2 safeties for tryouts
The Broncos brought in four free agent defenders for tryouts on Tuesday.
Washington’s Deuce Davis Continues Havoc at EDGE
Sunday afternoon saw the first reps that Russell "Deuce" Davis II has taken since his three-sack performance in the UCLA game of 2024. That year, he played just 34 defensive snaps before injuries sidelined him for all of 2025. In the Apple Cup, Davis recorded a sack on his first play back. He appeared on …
Patriots RB TreVeyon Henderson Receives Disappointing Week 1 Update
The New England Patriots have released an injury update for running back TreVeyon Henderson ahead of Week 1.
Midwest Aerial Athletics wins big in Aruba
SIOUX FALLS, S.D. (KELO) —KELOLAND News first took you to Midwest Aerial Athletics back in July. The gym was gearing up to compete on the international stage. “We just competed in Texas, and that was the qualifier for Aruba. So we’re going to Aruba this year and hopefully Australia and then Italy in the next […]
MAC Challenges Michigan Win, Big Ten Fires Back
The Big Ten has responded after the MAC accused its replay crew of failing to follow proper protocol during Michigan’s miracle win over Western Michigan.
Three-time MVP Aaron Judge returns to Yankees
BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]
Pritzker-backed PAC plans to bankroll anti-Trump candidates nationwide
The committee, called “Ready for the Fight” in reference to a line from Pritzker campaign speeches, launched today.
Aryna Sabalenka Shuts Down Reporter Over U.S. Open Party Question
The World No. 1 pushed back after a reporter described her pre-tournament week as 'lots of parties and fun.'
One Small Step: Sheriff and nonprofit leader discuss parenting amid political backdrop
Matt Carr and Stefani Wells recall their earliest political experiences and how that has shaped them today, as parents.
Gault Toyota Athlete of the Week is back
SOUTHERN TIER, N.Y. (WIVT/WBGH) – With high school sports back in season, we at News 34 are bringing back the Gault Toyota Athlete of the Week. Any high school athlete can be nominated, regardless of sport. We will send out polls on our website where you can vote for the Athlete of the Week from […]
Opposing court orders upend Missouri midterms just weeks before Election Day
(CNN) — Back-to-back court orders on Tuesday injected chaos into Missouri’s plans for this year’s midterms, with state officials and a group opposed to a GOP-friendly congressional map racing into
Supreme Court rejects Missouri’s request to use congressional map with extra GOP seat
The Supreme Court on Tuesday denied Missouri’s request to use a congressional map for the November midterm election that would have given Republicans a chance to flip a seat, a rare setback for the GOP’s effort to keep control of the House next year by eking out an advantage from its political boundaries.
Data center backlash reveals bugs in the political system - or are they features?
Local officials have more power than they're letting on in the fights over data centers.
From Backyard Ziplines to Self-Driving Cars: UCLA Computer Science Student Develops Tools to Help Autonomous Vehicles Safely Share Information
One of the fondest childhood memories of Alexandra Markova was a weekend spent running around Home Depot with her father and three siblings.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
GOG brings back "big box" PC games, one printable template at a time
Preservation "goodies" also includes downloadable 3D models for desktop perusal.
Andy Reid Officially Confirms Patrick Mahomes’ Week 1 Status
It has seemed like a forgone conclusion that Patrick Mahomes will start at quarterback for the Kansas City Chiefs Week 1, but it has not been set it stone. That changed on Tuesday when coach Andy Reid spoke to the media and officially confirmed that Mahomes will play Week 1 against the Denver Broncos on […] The post Andy Reid Officially Confirms Patrick Mahomes’ Week 1 Status appeared first on HEAVY.
Why Are So Many Parked Cars Catching On Fire?
When I was about nine years old, I was riding in the back of my family’s old ’68 Volkswagen Beetle when the car started to lose power and slow down. My mom, who was driving at the time, began to pull over to the side of the road, and at that moment I looked behind […]
49ers Predicted to Bring Back $88 Million Super Bowl Champion
The Athletic's Matt Barrows predicts the San Francisco 49ers will bring back an $88 million edge rusher. The post 49ers Predicted to Bring Back $88 Million Super Bowl Champion appeared first on HEAVY.
Colisée’s new owners pledge to ‘bring life back’ to Lewiston’s top entertainment, sports venue
The New York-based owners say the sale signifies a serious future investment in professional hockey in the city, as well as youth hockey, community events and more.
Senate Set to Vote to Begin Debate on Protect College Sports Act
Background The Protect College Sports Act of 2026 (PCSA), introduced in the Senate on June 2, 2026, by Senators Ted Cruz (R-TX) and Maria Cantwell (D-WA) and joined by Senators Eric Schmitt (R-MO) and Chris Coons (D-DE), represents a comprehensive federal legislative effort to reshape the governance and economics of intercollegiate athletics, including redistributing the significant media revenues generated by college sports. Reported favorably 19-9 from the Senate Commerce Committee and placed on Senate Calendar No. 449 on June 24, 2026, the PCSA was substantially revised on August 7, 2026 (Senate Amendment 6768). The PCSA arrives against a backdrop of cascading judicial decisions that have systematically dismantled the National Collegiate Athletic Association’s (NCAA) authority to regulate the economics of college sports.
'We're resilient': Maine businesses brace for new round of Canadian tariffs
Canada is officially striking back in the trade war with the United States.
College Football Has Completely Lost Its Mind
College football has been back for one full week . That’s it. And somehow we already have a tweet perfectly summarizing just how ridiculous this season has become. LSU is dealing with a legal fight that has reached the point where SEC leaders could vote on whether to expel the school from the conference. Western…
Nebraska Stat Tracker vs Ohio, Week 1
Nebraska 49, Ohio 21 — and the offense is a long way ahead of the defense Welcome to the first statistical breakdown of the 2026 Nebraska football season. I said back in the summer that I’d track a set of numbers all year to see how this team is actually doing, and this is the […]
We redshirted our son for kindergarten. Then he skipped a grade.
We held our son back for kindergarten because of different state cutoffs. When he became bored academically, we moved him ahead a grade.
US House bill requires criminal background checks on Hollywood sets
A House bill would require criminal background checks for Hollywood set workers who supervise or regularly interact with minors.
Kids are back in classrooms. Health misinformation could shape the school year.
Public health officials and medical experts worry that declining vaccination rates will lead to more children getting infected with preventable diseases.
The Villages Health’s $541 million settlement highlights the cost of ‘upcoding’
The settlement describes how The Villages Health would go back into patients' medical files months later and add diagnoses -- sometimes adding in monitoring, evaluations or treatments.
Puppy Pals Live Wags Its Way Back to the Niswonger
an Wert, OH [Sept 7, 2026] - Get ready for an afternoon filled with four-legged fun as Puppy Pals Live returns to the Niswonger Performing Arts Center on Sunday, September
Buffalo Bills name 6 captains for 2026 NFL season
Who joins quarterback Josh Allen and linebacker Terrell Bernard as an official captain for the Buffalo Bills in 2026?
Are the Chargers being disrespected?
Are the Chargers not receiving enough support from the media ahead of the season despite back-to-back 11-win campaigns?
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Cannibalism returned to the menu multiple times in Neolithic Europe
Bones collected from three caves in Spain reveal how cannibalism came back over thousands of years.
Government land-grab agenda hits key Senate race as Dem backs property takeovers echoing Mamdani
Maine Senate candidate Troy Jackson suggested the state should take over mobile home parks, echoing NYC Mayor Zohran Mamdani's housing agenda.
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
MAC now says Big Ten replay officials erred in adding 1 second back for Michigan's Hail Mary, asks NCAA to recognize Western Michigan as the winner
Joe Ryan Reflects On First Start Back From Injury
Although the 30-year-old right-hander was charged with the loss on Monday, he appears to be finding his rhythm again on the mound.
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
Why Don’t Diamondbacks Streak?
Inspiration. I very much enjoyed Jim McLennan’s The Arizona Diamondbacks Have Not Gone Streaking. I learned that the Diamondbacks have not won 7 consecutive games since 7 September 2017 (a very long time). And I tip my hat to JWinMesa for his comment to that article. A summary is that as measured by Total Streak […]
Business district battle in Back Bay Power Play
Back Bay's biggest landlord steps up its fight against a business improvement district for the neighborhood.
🚨Confirmed XIs: Dortmund host Villarreal in their European opener
The 2026/27 UEFA Champions League kicks off in style at the mystical Signal Iduna Park. Borussia Dortmund come in as favorites, backed by three straight wins and Serhou Guirassy’s firepower up front...
Detroit’s iconic Hotel Yorba has a new owner whose plans are still in flux
The new owner said he had originally planned on an affordable housing conversion but has gone "back to the drawing board" after a meeting with nearby residents.
Why Lewis Dunk Is STILL Brighton's Most Underrated Player
The veteran skipper remains the common denominator in Brighton’s success, transforming raw defensive partners into stars while proving he is the timeless heartbeat of the Seagulls’ backline.
Emmet Sheehan made the most of his return
Emmet Sheehan had such a successful first start back with the Dodgers that he earned at least another, after striking out 10 Cincinnati Reds in Monday night’s win at Dodger Stadium, his first start in the majors in five weeks. “There was a lot of stuff going down, and try to figure stuff out in […]
Kansas State Adds Former Temple CB Ben Osueke
Temple Owls cornerback Ben Osueke was granted an extra year of eligibility and has decided to play for the Kansas State Wildcats
Cowboys Predicted to Add Champion George Pickens Replacement
The Dallas Cowboys could have a high-scoring offense with George Pickens back. But assuming he leaves after this year, could a college star replace him? The post Cowboys Predicted to Add Champion George Pickens Replacement appeared first on HEAVY.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
Vikings Re-Sign Edge Rusher Kenny Dyson To Practice Squad
Dyson is back with in Minnesota as the team was clearly impressed with his skillset.
Rangers Postseason Outlook with 18 Games Remaining
Sitting just two games back in the AL West, the Texas Rangers enter a high-stakes stretch featuring a West Coast trip and a season-defining homestand.
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
Arsenal is watching back to back Champions League winner
Arsenal continue to eye top players who can improve their squad, and several names are on their radar, with Willian Pacho now emerging as one of the stars they want to sign. The Ecuadorian defender ha...
Carole Radziwill says ‘the emotions all came back’ when “Love Story” aired while she filmed her return to “RHONY”
Radziwill is related to John F. Kennedy Jr. through marriage; her late husband, Anthony Radziwill, and JFK Jr. were first cousins.
Kansas City psychiatrist explores the science behind high emotional sensitivity
Dr. Sasha Hamdani's new book, "Too Sensitive," aims to provide a science-backed, empathetic framework for understanding why some people experience high emotional sensitivity. The Kansas City psychiatrist joined KCUR's Up To Date on Tuesday.
NESN Announces Bruins Preseason Broadcast Schedule & Programming
The four-game slate begins September 20 and also includes "Bruins: Back to Work Pregame" and "Bruins: Back to Work Postgame" on game days.
Heat linked to reunion with struggling ex-Lakers point guard
An NBA writer believes the Miami Heat should consider bringing back a former Los Angeles Lakers backcourt contributor for a second stint.
Week 1 Reminded Us Why College Football Is the Best
College football is officially back. And somehow, Week 1 already gave us enough storylines for an entire season. The biggest statement came from LSU . Lane Kiffin’s debut couldn’t have gone much better, as No. 11 LSU absolutely destroyed Clemson 51-10 in Death Valley. LSU piled up 644 yards while holding Clemson to just 145.…
Your vote. Your child’s classroom. Your electric bill. Your water. Your health.
More than 95% of cases in this country are handled by state courts. And as the U.S. Supreme Court pushes fundamental questions about our freedoms back to the states, state courts and state constitutions are increasingly important protectors of our rights.But those protections only mean something if the judges sitting on our Supreme Court are willing to enforce them.
See Mark Harmon's return as Gibbs in 'NCIS: Origins' trailer
Mark Harmon is back in action as Leroy Jethro Gibbs.
From 'Love Hypothesis' to 'Fourth Wing,' 60 BookTok favorites coming to screens
Hollywood is finally catching up to BookTok. The well-read corner of the internet brought decade-old titles back to bestseller lists and new life to bookish communities.
'Practical Magic 2' brings back the magic and the mess
The Owens sisters are as bewitching as ever – multiple generations of them, in fact – in “Practical Magic 2,” even if the sequel might only truly cast a spell
Oil prices surge back toward $100: What market pros are saying
Oil is creeping back toward $100 a barrel, fueling a Labor Day record for US gas prices over the long weekend.
Christal Jordan has the latest in entertainment headlines
The Duke & Duchess of Sussex are back in the UK, and Phaedra Parks has a new beau. Keep up with Christal on social media @threalchristaljordan
Are Irving, LaVine, Holiday realistic for Heat? And surprising Richards info
The Heat’s challenges in landing one more impactful player. And some notable data on new backup center Nick Richards.
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
Rock Creek Entertainment District in Norman faces another legal battle
A judge will hear arguments on Tuesday as the legal battle over the $1.1 billion Rock Creek Entertainment District in Norman heads back to court.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Fantasy Football D/ST Rankings: Week 1 2026
There is plenty of fantasy football speculation running backs . And there are some undervalued tight ends . But people often forget about the defenses. Don’t do it! Pick a good one and stick with it. And here are the fantasy football defense and special teams rankings for Week 1 of the 2026 NFL season. The Week 1 list looks a lot like the usual […] The post Fantasy Football D/ST Rankings: Week 1 2026 appeared first on ClutchPoints.
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🥱 Welcome Back. Hope you enjoyed your holiday weekend. 🎶 Your Morning Pick Me Up. Welcome Back. John Sebastian PA Weather☀️ Erie | Mostly Sunny, 77🌤️ State College | Partly Sunny, 81☀️ Allentown | Mostly Sunny, 81 PA Sports ⚾ Phillies (81-63, -4.0 GB, +4.5 GB WC) | Atlanta 1-0 |…
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