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Why are airplanes so cold? It’s for your health.
From combating fainting to helping aircraft work efficiently, planes are chilly for a reason.
These tiny soil microbes could rescue crops from salty farmland
Researchers have discovered that beneficial soil bacteria give plants an unexpected survival advantage in salty soils. Instead of helping plants keep salt out, the microbes stimulate the production of lignin, a natural compound that strengthens roots and makes plants more resilient. Greenhouse and field tests showed healthier plants and higher yields in salty conditions. The findings could lead to bio-based treatments that help farmers grow crops on land once considered too salty for agriculture.
Only one workout helped older adults lose fat without losing muscle
A six-month study of more than 120 adults in their 70s found that high-intensity interval training (HIIT) may offer a key advantage over other forms of exercise: it helped reduce body fat while preserving valuable muscle mass. While moderate and low-intensity workouts also led to some fat loss, only HIIT maintained lean muscle, which becomes increasingly important with age.
Only one workout helped older adults lose fat without losing muscle
A six-month study of more than 120 adults in their 70s found that high-intensity interval training (HIIT) may offer a key advantage over other forms of exercise: it helped reduce body fat while preserving valuable muscle mass. While moderate and low-intensity workouts also led to some fat loss, only HIIT maintained lean muscle, which becomes increasingly important with age.
Peer Support May Be the Answer to the Mental Health Crisis
Peer support is the sleeping giant that may help us overcome the social and mental health crises we currently face.
Science & Medicine: Scanning the brain to improve treatment for traumatized teens
Around 20% of teens who have experienced emotional trauma don't respond to talk therapy. UT Health San Antonio is using neuroimaging to track brain changes in traumatized teens during a course of therapy to see if they can figure out why, which could lead to the development of more personalized treatments that will help more teens heal.
Anaheim Ducks help Wisconsin Badgers extend major NHL draft milestone
This weekend's NHL Draft marks 29 straight where the Wisconsin Badgers have had a player selected.
Despite Mayor Brandon Johnson campaign promise, 911 mental health response team flounders
Throughout his 2023 mayoral campaign, Brandon Johnson championed a progressive vision of sending teams of mental health clinicians instead of police officers to help people suffering from psychiatric emergencies. But since he took office…
I overcame my fear of learning about AI and landed a Big Tech AI job
A product designer share how embracing her inner "mad scientist" and experimenting with AI helped her land a job at Adobe, with no formal background in machine learning.
I overcame my fear of learning about AI and landed a Big Tech AI job
A product designer share how embracing her inner "mad scientist" and experimenting with AI helped her land a job at Adobe, with no formal background in machine learning.
Elliot Anderson’s Manchester City transfer arrangements see last-minute change
Adaptations have been made to the final medical checks for Manchester City’s record transfer for Elliot Anderson.The 23-year-old put in an 84-minute shift to help guide England through a highly comp...
Today's NYT Connections: Sports Edition Hints, Answers for June 28 #643
Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.
Florence community rallies for local business owner diagnosed with brain tumor, here’s how you can help
The Florence community held a fundraising event for a local business owner who was diagnosed with a brain tumor for the second time.
Local business gathers donations for Venezuela earthquake victims
HARRISBURG, Pa. (WHTM) — A local business is stepping up to help earthquake victims in Venezuela. The Arepa House on Second Street in Harrisburg is accepting donations all day Sunday. They sa…
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
PHOTOS | Multitude enjoy aerial entertainment at resurgent Texarkana Airshow
Sgt. 1st Class Benjamin Hall, assistant team leader, watches the ground to help the Golden Knights line up with their jump mark at the Texarkana Airshow on Saturday at Texarkana Regional Airport. Throngs of people lined a taxiway at the airport to watch the Army parachute team and other aerial entertainment. It was the first airshow in the city in nearly 30 years. See Monday's edition for extended coverage.
Hawaii is turning ocean plastic and fishing nets into roads
Hawaii researchers are giving old fishing nets and recycled plastic a second life by mixing them into asphalt roads. Early tests found these roads didn't release more plastic particles than standard pavement, with tire wear overwhelming any plastic signal from the recycled material. If future studies confirm the roads are durable, the technology could help tackle both marine pollution and overflowing landfills.
Report: Astros to Call Up RP Miguel Ullola
The Houston Astros are calling up pitching prospect Miguel Ullola, according to a report from Chandler Rome of The Athletic. Ullola, 24, is ranked as the Astros #11 prospect per MLB.com. Ullola was converted to a reliever this season in an effort to help him with his command issues and be someone the team could […]
AI Is Helping Small Businesses Get More Done, But It’s Far From The Only Productivity-Booster Helping Them Expand
Getting more done in less time is easier than ever for solopreneurs and small business owners, thanks to the ease of hiring contractors, using QR codes, touchless technology and other affordable methods.
Community Market Series creates space to support small business
A new market in Boardman is hoping to bring the community together to help support small, local businesses.
Oklahoma City business taking donations to help Venezuela following multiple earthquakes
Venezuelan restaurant VeneBurgers is organizing donations to provide Venezuelans with necessary items.
Free health clinic aims to expand care access on city's West Side
Free preventive care is coming to San Antonio’s West Side Saturday. The Health Collaborative’s Neighborhood Clinic offers 3D mammograms, screenings, vaccines, dental checks, food and help connecting to ongoing care.
Community helps rebuild Future Champions Sports Complex
Now, one year after the disaster, Jamison said he reflects on the support he was shown.
Local businesses step up to help victims of deadly Venezuelan earthquakes
After a devastating series of earthquakes shook Venezuela, business owners in Columbus have found a way to step in and send help.Hundreds are dead, with thousa
Central NY farm in business for more than 80 years faces costly rebuild after fire
Community members and farmers have rallied to help the farm cleanup and rebuild after a fire destroyed its greenhouses.
Can Gov. Ferguson heat up WA's cooling economy?
Amid rising concerns over a cooling economy – and criticism of the state's negative business climate – Ferguson is looking for help from Amazon, Boeing and other big employers.
Which coach helped Dianna Russini get out of a ticket?
The recent New York Times article regarding former New York Times reporter Dianna Russini answered some lingering questions.
Yellowstone’s supervolcano may be fueled by something unexpected
Scientists have uncovered a new explanation for what powers Yellowstone and other supervolcanoes. Instead of a deep plume rising from near Earth’s core, a broad “mantle wind” may push hot rock beneath Yellowstone, generating magma closer to the surface. This process helps create a massive underground magma network and may explain how supervolcanoes remain active for long periods.
Scratching that bug bite might feel good at first but science explains why it's a bad idea
You scratched that bug bite and now it's a big itchier bump. Some science explains why scratching really can make things worse, even if you don't break the skin. University of Pittsburgh researchers put tiny “cones of shame” onto mice to help unravel what happens on a cellular level when an itch ...
A lack of funding, a glut of stigma: How Ohio LGBTQ+ health outcomes are impacted
Being able to access healthcare in general is a struggle for LGBTQ+ individuals, and with legislation in Ohio and elsewhere that banned gender-affirming care for minors, for example, a need for healthcare can often clash with the hesitation to seek help.
Colorado Politics Calendar June 29-July 5
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
How complex surgeries helped a Texas man avoid foot amputation
A Texas man nearly lost his foot in a lawn mower accident, but Houston doctors saved it through a series of complex surgeries.
On a mission to support the Valley’s small businesses
The SBDC goal is to help small Valley businesses thrive, not just during the startup process.
California health insurance tax hike: Will your premiums increase?
A balance act: To help fund the safety net, lawmakers have voted through a health tax extension that could increase premium costs for Californians with private insurance.
Breakfast, lunch, dinner to hit 30g fiber goal: Nutrition scientist
You may eat fiber for gut health, but it plays many crucial roles in the body, from lowering cholesterol to helping to control glucose levels.
Just 2 Hours of Strength Training May Lower Heart Disease Risk in Women
Researchers say that just 2 hours of weekly strength training may help lower the risk of cardiovascular disease in women, especially when paired with 150 minutes of weekly aerobic exercise.
Trossard, De Bruyne score and Belgium defeats New Zealand 5-1 to advance at the World Cup
A flurry of late goals helped secure Belgium’s place in the knockout rounds, while New Zealand are heading home without a win.
Audio: RFK jr. urges Libertarian candidate to drop out race to help GOP keep House
Audio: RFK Jr. urges Libertarian candidate to drop out race to help GOP keep House
OutFront obtains audio of US Health and Human Services Secretary Robert F. Kennedy Jr. urging a Libertarian congressional candidate in Iowa to drop out of the race to improve Republicans’ chances of winning - and keep control of the House. Rick Stewart, who had no prior relationship with RFK Jr., tells Erin Burnett it’s “ludicrous” a Trump cabinet official would make such an offer.
Police seek help identifying suspect in California Avenue business break-in
The Bakersfield Police Department is asking for the community’s help in identifying a man accused of breaking into a business on California AvenuePolice said it
We almost had a smartphone in the 90s. Why did it fail?
In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.
The 5-Question Org Chart Audit I Run Before Scaling AI Across a Business
AI success depends less on the technology and more on the organization behind it. These five questions help leaders identify the structural barriers that prevent AI from delivering real business impact.
What if the economy gets better and it doesn’t help the GOP?: From the Politics Desk
Plus, Gavin Newsom’s next move in the billionaire tax fight.
MSU Vet Tech program awarded $150k NIFA-USDA grant
Morehead State University's nationally ranked veterinary technology program was recently awarded significant financial support to help it maintain its place as the #1 program of its kind in Kentucky. The National Institute of Food and Agriculture (NIFA), part of the United States Department of Agriculture (USDA), awarded MSU's vet tech program a $150,000 NIFA-USDA grant for equipment to support small and large veterinary technology education and workforce competency at MSU. Learn more about veterinary technology programs at MSU by emailing Staton at a.staton@moreheadstate.edu or calling 606-783-2328. Find out more about MSU's veterinary technology program by calling 606-783-2662.
PlayStation hardware sales fall to their lowest May total since 2000
Price rises hit Sony's console sales, but 007 First Light and Switch 2 help US game spending to grow 3%
Why the Amex Business Gold is my go-to card for business expenses
The Amex Business Gold makes earning rewards simple with automatic bonus categories, flexible Membership Rewards points and statement credits that help offset its annual fee.
John Bolton pleads guilty to illegally retaining classified information
His plea deal with federal prosecutors could help him avoid prison time
Can We Engineer Being on the Same Wavelength with Others? Research Offers a Cautious “Yes”
Analysis shows science can help us become synchronized over time—and feel more connected to others in the process
Meet A Retriever—Manikanta Sirumalla, International Data Science Graduate Student And Entrepreneur - UMBC: University Of Maryland, Baltimore County
If you want help meeting a big new fitness goal, Manikanta Sirumalla may have the app for you. Manikanta came to UMBC from India as a graduate student
Starlink veterans launch startup to broaden megaconstellation ownership
Former SpaceX engineers who helped build and scale Starlink have launched a startup aiming to deliver megaconstellations for governments and companies seeking more control over space-based infrastructure.
UNESCO places science and knowledge at the heart of recovery efforts
At the Ukraine Recovery Conference (URC) 2026, held in Gdańsk, Poland, on 25–26 June, UNESCO announced a new package of support of over EUR 2,5 million to help rebuild Ukraine’s scientific and
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Strength Training Could Be One of the Best Things You Do for Your Brain
A growing body of research suggests strength training can help preserve cognition and improve brain health as you age. Experts explain the best way to work strength training into your routine.
Nevada takes step toward becoming corporate litigation hub with business court pilot program
The Clark County District Court this week announced it has restructured its departments to include a dedicated business court. The restructuring is expected to bring down case adjudication times, and it could help an ongoing effort to transform Nevada into a premier destination for corporate litigation. Judges Maria Gall and Joe Hardy–Departments 9 and 15, […]
Science Heroes: Digging It at Groton Public Library
Unearth your love for science in this fun and interactive S.T.E.M. show for the whole family. With help from audience volunteers, we’ll conduct exciting experiments about the changing states of […]
French people are painting chalk on their windows in the heat
A simple, low-tech remedy may help cool homes. Here's the science behind the trend.
This Democratic congresswoman almost helped elect a Republican speaker
Rep. Marcy Kaptur (D-Ohio) explains why she contemplated supporting Rep. Kevin McCarthy (R-California) in 2023 with an extremely rare crossover vote.
The heatwave hacks that will actually help to keep you cool
Should you wear wet socks to bed or point a fan out the window? Can the ‘Japanese door fan’ technique cool a baking hot car? Here’s what the science says
Best Prime Day laptop deals: Save up to $970 on MacBooks, Windows PCs
Laptops are very expensive these days. These discounts help.
CRAWFORD | Kenny Klein, beloved longtime Louisville sports information director, dies at 66
Klein's career spanned nearly four decades and helped shape the public face of Cardinals athletics through some of its greatest triumphs and most difficult crises.
Serious statin side effects on muscles are extremely rare, new research confirms
Scientists created a new tool to help doctors predict a patient’s risk of severe muscle problems from taking a statin.
Plaucheville business opens parking lot to Red Cross, polling site after flooding
One week after Avoyelles Parish received nearly 30 inches of rain in less than 12 hours, 2 Sisters’ Salsa is opening its parking lot to help the community recover.
Plaucheville business opens parking lot to Red Cross, polling site after flooding
One week after Avoyelles Parish received nearly 30 inches of rain in less than 12 hours, 2 Sisters’ Salsa is opening its parking lot to help the community recover.
Health Watch: Scientists say animal therapy helps critically ill patients, prompting new legislation
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Why cannabis businesses need to apply for DEA registration now – and why states must help
Cannabis businesses should apply for DEA registration by a Friday, June 26 deadline. And states should be helping them.
Microsoft Discovery Aims To Advance The Era Of Agentic Science
The cloud-based agentic AI platform aims to help human researchers overcome resource constraints and complex data challenges to accelerate science at scale.
Governor Mills Celebrates Groundbreaking for Youth Mental Health Treatment Facility in Saco
Saco, MAINE-- Governor Janet Mills today participated in a groundbreaking ceremony for Sweetser's new youth psychiatric residential treatment facility. Governor Mills and the Legislature secured more than $5 million to help build the treatment facility.
Short-form science: University of Washington researchers launch PaperTok to combat AI slop
A University of Washington team is helping scientists tell their own stories with a free tool that converts dense, jargon-heavy publications into short, accessible videos.
Two NC lawmakers, a Democrat and a Republican, push Congress to delay SNAP changes
Above the federal penalty threshold, NC could owe $140M a year, putting at risk a program that helps over 1.2 million North Carolinians.
Agentic-Native Platforms Are Creating A New Technology Business Model
For decades, the enterprise technology industry operated on a simple principle: software companies built products, and services firms helped enterprises.
Gillings-supported center helps public health teams prioritize infectious disease risks, from measles to the World Cup - UNC Gillings School of Global Public Health
June 25, 2026 When public health workers prepare for infectious disease threats, the question is rarely whether risk exists. It is where to focus first.
Vote for ESPYS 2026: Best Athlete - Men's Sports
Vote today and help determine which athletes go home with an ESPY
Vote for ESPYS 2026: Best College Athlete - Men's Sports
Vote today and help determine which athletes go home with an ESPY
RFK Jr. urged Iowa candidate to make deal to help GOP win House seat, per audio recording
The health secretary urged Iowa Libertarian candidates to drop out of key races to help Republicans keep control of Congress, according to interviews and a recording obtained by The Post. The effort highlights mounting GOP anxiety over the battle for the House.
$10 Million Gift to UAB Aims to Improve Rural Health Care Across Alabama
A $10 million gift to the University of Alabama at Birmingham will help train more primary care physicians in rural communities and encourage them to stay and p
Ohio State–led team secures NSF award to advance to next phase of the National Quantum Virtual Laboratory program
The Ohio State University is strengthening its growing prominence in quantum science, technology, and education with a $4 million, two‑year Phase II design award from the U.S. National Science Foundation (NSF) to advance a national effort focused on next‑generation quantum sensing.The funding is helping to bring together top researchers and ...
'This is the next jump in technology': World's first sub-1nm chip keeps Moore's Law alive a little longer
IBM's NanoStack architecture has helped scientists cram 100 billion transistors onto a computer chip, delivering 50% better performance and consuming 70% less energy than the current generation.
David P. O'Brien
About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.
Scientists discover how a single cell builds a brain with 170 billion cells
How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.
FDA-approved drug may finally help immunotherapy defeat rare liver cancer
Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.
Ensuring health for Special Olympics athletes
University of Minnesota healthcare students across many disciplines are helping to provide health screenings for athletes competing in the 2026 Special Olympics USA Games.
Democracy’s Defenses, Democracy’s Undoing
A broad range of views on democracy to help break the stalemate caused by partisan conflict.
What are the best businesses in Centre County? Submit your nominations to CBICC
Your input can help recognize a deserving local business or nonprofit organization.
Best Prime Day laptop deals: Save up to $970 on MacBooks, Windows PCs
Laptops are very expensive these days. These discounts help.
If Virginia’s ‘best state for business’ ranking falls, data center taxation debate will get the blame
But will Virginia fall? We don’t know yet, but we do know how CNBC has changed its formula. Here’s a look at whether that helps or hurts the state.
How is Derry City's new pitch 'World Cup standard'?
Ahead of Friday's first game back at the Brandywell, BBC Sport learns how a giant sewing machine has helped put Derry City's new hybrid pitch together.
Imaging-related burdens may be keeping some from completing cancer screenings
Targeted interventions could help reduce pre-test anxiety, improve the physical screening experience, and address structural barriers in underserved settings.
Restaurants Care Resilience Fund helps local businesses stay afloat
UNM Project ECHO Works Closely with World Health Organization on Disease Outbreaks
When a major disease outbreak occurs, the World Health Organization (WHO) calls on Project ECHO at The University of New Mexico Health Sciences Center to help support the transmission of accurate, timely health information to clinical health workers and...
Liverpool signs find a way to support business
EAST LIVERPOOL-As part of the revitalization process for the historic downtown area in East Liverpool, two wayfinding signs have just been installed in the downtown area to help direct people walking through downtown to businesses located in the area. The wayfinding signs, which have smaller directional signs on them pointing out the locations of multiple […]
Mount Dora business owner scrambles to help homeless man, learns Lake County has no emergency homeless shelter
A Mount Dora laundromat co-owner is rallying support for a homeless man after discovering Lake County has no emergency shelter and few local resources.
WATCH: Palmetto Sports Team LIVE at Greenville Drive’s “Game Show Night”
The Palmetto Sports Team gets ready for the Greenville Drive’s “Game Show Night” with a look at the Hot Dog of the Homestand and the help of mascot Reedy Rip’It and Drive host JDew.
Mercy Helps Position St. Louis as Global Gateway for Healthcare Innovation
Mercy continues to bring innovative thought leadership to the communities it serves and beyond. Dr. Damon Broyles, Mercy vice president of clinical innovation, informatics and precision medicine, recently shared insights and helped attract new companies to St. Louis’ nationally recognized healthcare industry as part of BioSTL.
Scientists seek clues to longevity from three Brazilian sisters over 100
What is the secret to a long life? Three Brazilian sisters with a combined age of 316, who were named by Guinness this month as the oldest living trio of siblings in the world, may help researchers find out.
New Patient Guidebook Helps Puget Sound Beneficiaries Navigate Their Health Care
MADIGAN ARMY MEDICAL CENTER, Joint Base Lewis-McChord, Wash. -- Great news for military communities and TRICARE beneficiaries across the Pacific Northwe...
Anthropic Veterans’ Startup Seeks to Help Scientists Develop Their Own AI
Mirendil raises $200 million from Andreessen Horowitz and Kleiner Perkins to make AI that can do the job of an AI engineer.