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Caesars Entertainment (CZR) Expands In Maine Online Gaming, Is The Stock Already Fully Valued?
Caesars Entertainment expands digital footprint with Wabanaki Nations partnership Caesars Entertainment (CZR) is extending its partnership with three Wabanaki Nations to include online casino gaming in Maine, targeting a potential 2026 iGaming launch, subject to regulatory approvals. See our latest analysis for Caesars Entertainment. Caesars Entertainment shares have climbed over recent months, with a 90 day share price return of 16.79% and year to date gain of 28.14%. However, the 5 year...
Scalpers Are Already Flipping Steam Machine Reservations On eBay For $2,700–$2,900, Roughly Double Valve’s Price
Reservations for the Steam Machine are listed on eBay for up to $2,899, nearly triple its official price of $1,400, amid widespread scalping efforts
Venezuela Quakes Push Fragile Health System to the Brink
Earthquake victims are overwhelming healthcare centers in Venezuela’s coastal state of La Guaira and beyond, pushing an already fragile health system past its limits.
Recent rulings show that SCOTUS has ditched reason for politics
'The flurry of 6-3 decisions shows how SCOTUS has become a political body, not the judicial one the founders of our Constitution sorely aspired to,' writes an L.A. Times reader.
The #1 Snack for Better Gut Health, Recommended by a Gastroenterologist
Looking to improve your gut health? Read on to discover the best gastroenterologist-recommended plant-based snack to add to your day.
Letters to Sports: Is Austin Reaves worth the $185-million deal?
L.A. Times readers weigh in on the re-signing of Lakers guard Austin Reaves, as well as the Dodgers' hits and misses.
5 Hobbies You Can Turn Into Small Business Ideas
Looking to start your own business? These small business ideas let you monetize what you already love doing.
After ousting Bill Cassidy, Donald Trump faces fresh test of his sway with GOP voters in Louisiana’s Senate runoff
Louisiana Republican voters already rejected an incumbent senator who was crossways with President Donald Trump. In a primary runoff on Saturday, they’ll decide whether to follow Trump’s lead in choosing a new nominee.
Fallout from USMNT loss to Turkey and previewing the Mbappe-Haaland clash
On today’s show, we look back at the United States’ final group stage match against Turkey and evaluate their readiness for the Round of 32. Manchester City insider Sam Lee joins us to preview the tournament’s first true superstar heavyweight clash as Kylian Mbappe and France square off against Erling Haaland and Norway in a battle for Group I supremacy. Plus, The Athletic’s Jay Harris is back in the studio to break down the latest bracketology, advancement percentages, and qualification permutations for Groups G, H, and I using The Athletic’s World Cup Tracker.
Caleb Williams Calls Out NFL, Echoes Bold George Kittle Message
Chicago Bears quarterback Caleb Williams is already a leader of his team, and now he is leading with regards to the entire NFL. The post Caleb Williams Calls Out NFL, Echoes Bold George Kittle Message appeared first on HEAVY.
Meet a scientist tracking invasive reptiles, and even their parasites
An insider's look at Florida’s war on invaders: the giant snakes, egg-eating predators and parasites spreading through the Everglades.
Stenberg Excited To Join Sharks, Believes He’s NHL-Ready
Ivar Stenberg says he is ready to be in the NHL next season. After being drafted No. 2 overall by the San Jose Sharks, he becomes yet another another big-name, highly-skilled player in their under-23 group. “They have something really good going on, so super happy to join a special group,” Stenberg said. The 5-foot-11 […] The post Stenberg Excited To Join Sharks, Believes He’s NHL-Ready appeared first on San Jose Hockey Now.
Our Editors Found 401+ Best Amazon Prime Day Deals Worth Shopping Before the Sale Ends
You have less than 24 hours left to shop deals across categories, and some of them are so good that they’re already selling out.
7 Best of the Best Prime Day TV Deals Under $1,000 I Recommend Looking at Before They Expire Tonight
From gaming-ready to budget-friendly, these TV discounts are worth grabbing before Prime Day ends.
Author Meg Cabot says she's read the 'Princess Diaries 3' script 'and it was amazing'
Meg Cabot, author of the 'Princess Diaries' book series, says she's read the script for 'The Princess Diaries 3' starring Anne Hathaway and it's 'amazing.'
Seattle World Cup match brings fans, Pride weekend, and global politics together
The World Cup’s stop in Seattle has already delivered packed streets, record-setting business days and a surge of international energy around Lumen Field.
Readers Write: Traffic speeds, bike lanes, deportations, political characters, kids these days
On the road, chill out and save money.
This Week's 10 Must-Read Stories on Women in Politics: Title IX Anniversary, AI's Anti-Women Bias and Ranked-Choice Voting Victories
Weekend Reading on Women’s Representation is a weekly compilation of stories about women’s representation in politics, on boards, in sports and entertainment, in judicial offices and in the private sector in the U.S. and around the world—with a little gardening and goodwill mixed in for refreshment! Published every Friday. —This week marked the 54th anniversary of Title IX. —As the Taliban approaches the five-year mark of its return to power this August, a rare protest in western Afghanistan last week laid bare both the brutality of its rule and the resilience of those living under it. —A woman will replace Eric Swalwell in California … but for not two more months. —A study of 133 AI systems found that 44 percent demonstrated gender bias, and more than a quarter showed both gender and racial bias. ... and more.
50 Cool Charts That Will Make You So Much Smarter
Reading this is like going to college in five minutes.
We almost had a smartphone in the 90s. Why did it fail?
In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.
Trump tries out midterms message that focuses on ‘communists’
Trump warned an audience of religious conservatives that communism is spreading in the U.S., a new theme for his midterm campaign.
Supreme Court says Alito’s verbal reaction to Sotomayor was a ‘misunderstanding’ by Alito
The highly unusual exchange between Justice Samuel Alito and Justice Sonia Sotomayor over a dissent read from the bench was based on a “misunderstanding” by the conservative justice, the Supreme Court said Friday.
A new “Supergirl”, the end of “The Bear”, and a fisherman thriller top this week's Must List
Book of Love's 40th anniversary album and "Dad Don't Read This" round out our picks for the weekend of June 26.
General Atlantic Serves Up Djokovic Hire in Sports Push
The private-equity firm has already invested in a number of sports assets.
Windows 11 is getting redesigned taskbar settings in new build
Microsoft is giving Windows 11 redesigned taskbar settings, and the changes are already available for testing in the latest build.
Have the Astros found their 8th inning guy?
Have the Astros already found their setup man before the deadline?
The Venezuela Earthquakes Hit a Health System Already in Crisis
Firefighters are using cellphone lights because of a flashlight shortage, and an overwhelmed hospital in the disaster zone is operating without running water, one doctor said.
As Pa. measles outbreak worsens, state health official issue strong call to action: 'We are not just sitting back and watching this virus spread'
LANCASTER, Pa. — State Health Secretary Debra Bogen on Friday issued a strong call to action in the wake of a measles outbreak not seen in Pennsylvania...
Epic's Tim Sweeney Keeps Inventing Solutions To Problems That Are Already Solved
Quick, someone tell him what Discord is
Community Challenge Chaos Spreads
To celebrate the release of the Chaos Cubed game drop, the mayhem continues with our Chaos Spreads Community Challenge! Unite with your friends and play with the free add-on reward, courtesy of completing the Chaos Sparks Community Challenge. Players can collectively win a new Bedrock world for all from Blockception!
Canada Inc. Is Ready for a Blockbuster Summer: Five Stories to Watch
Also: What’s behind sky-high bank valuations
Summer Science Program
Explore information about the Summer Science Program at Arkansas Children's Hospital, a career readiness program for college students, including eligibility and how to apply.
AI Is Already Reshaping US Politics at Every Level
From data center backlash to boundless cash from tech billionaires and concerns about deepfaked campaign ads, AI is everywhere in the 2026 US elections.
Andy Cohen cries as he mourns 28-year-old 'WWHL' producer who died of brain cancer
Andy Cohen became emotional mourning 'Watch What Happens Live' production manager Kyra Samson, 28, who died of brain cancer earlier this week.
NASA’s PACE Mission Studies Smoke, Fires
With the North American fire season underway, and a record number of acres already burned nationwide, NASA’s Plankton, Aerosol, Cloud, and ocean Ecosystem
Remigration: a growing far-right movement
Once a fringe position, calls for mass deportation are spreading throughout Europe and entering mainstream politics
Texas school board to vote on required Bible readings in public education
If approved by the Texas State Board of Education, which is controlled by Republicans, the reading list would take effect in 2030.
Is AMC Entertainment Holdings (AMC) Undervalued Or Is Its Recent Rally Already Priced In?
AMC Entertainment Holdings (AMC) is under renewed scrutiny as investors weigh its recent share price swings and ongoing losses against reported revenue of $5,031.8 million and a market value of about $1.5 billion. See our latest analysis for AMC Entertainment Holdings. At a share price of $1.89, AMC Entertainment Holdings has seen sharp swings, with a 7 day share price return down 33.22% but a 90 day share price return up 99.33%. The 1 year total shareholder return is down 37.42%, indicating...
Chaotic Push to Train Staff for US Ebola Outbreak Facility Alarms Health Workers
The three-day session focused more on administrative tasks than spread prevention.
Ball State Teacher Preparation Programs Earn Top Ratings in Science of Reading Reviews
By Ball State Communications— MUNCIE, Indiana — Ball State University’s elementary education, early childhood education, and special education teacher preparation programs have earned top marks in two reviews focused on how well future educators are prepared to teach reading through evidence-based,
ConcernedApe Explains Why He's Shown So Little Of Haunted Chocolatier: 'I Would Rather Serve A Fully Baked Bread'
Eric Barone posted his first blog update in six months yesterday to reassure fans he's still hard at work.
Valve's HDMI 2.1 Saga Is "Fully Resolved" with a Final FRL Update to Come For Full 4K 240Hz support
My monitor is ready.
Scientists stunned by signs of ancient life in a place no one expected
Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.
Braille is literacy: Rice researchers are reshaping the science of reading
As schools across the country increasingly embrace evidence-based approaches to reading instruction through the science of reading, two Rice researchers are leading an effort to ensure students who learn through braille are not left out of the research shaping literacy education.
Small Creatures, Big Mission: NMHM Bugapalooza 2026 Connects Science and Military Readiness
Mosquitoes, ticks, flies, and pollinators drew a crowd at the National Museum of Health and Medicine's Bugapalooza on June 13. Nearly 400 visitors attended the annual event to explore the world of insects through hands-on activities, exhibits, and conversations with military and civilian experts.
New York is already exporting Mamdani-style politics
Some of the institutions behind Tuesday’s progressive surge are already supporting candidates around the country
NC Democrats demand lower utility costs + budget talks drag on as deadline nears
Read our Under the Dome newsletter and listen to our Under the Dome podcast to stay up to date on #ncpol.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Notre Dame 2026 Player Profile: Wide Receiver Devin Fitzgerald
As the son of an NFL legend, this physical Arizona standout is already flashing elite route-running and contested-catch skills after a dominant spring debut in South Bend.
Real Madrid’s summer spending spree creates unexpected Champions League problem
Real Madrid have been one of the busiest clubs in the transfer market, but their impressive recruitment spree may have created a technical issue.Notably, Jose Mourinho has already welcomed four new si...
Hall of Fame GM Expresses Concerns About Extending Vita Vea
As a lucrative "hold-in" intensifies, Bill Polian warns that committing massive capital to an aging nose tackle could backfire for a Tampa Bay roster already in transition.
Fitbit Air's first update is already rolling out, and it could finally fix its biggest annoyance
Google has started rolling out the Fitbit Air's first firmware update since launch. This update promises bug fixes and improvements.
What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
Three Chicago Bears make CBS Sports’ Top 100 NFL Players of 2026 List
With the NFL on a break, get ready for list season, and CBS Sports just dropped their Top 100 Players, and three Chicago Bears made the cut.
‘Turf Tank’ robot elevates Oregon sports fields
The Oregon Youth Soccer Association is taking advantage of some new technology to keep its fields game day ready.
👀 Brazil learn first World Cup knockout opponents
The Brazil National Team already knows who it will face in the FIFA World Cup Round of 32.Vini Jr., Matheus Cunha & Co. will take on Japan in their first knockout match of the World Cup. Japan finish...
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
The Big Summer Preview
New jetbikes, grav vehicles and Dreadnoughts revealed for Warhammer 40,000 AND Warhammer: The Horus Heresy.
The Big Summer Preview – New Starter Sets and ready painted terrain
Dive into Warhammer 40,000, and fight on the battlefields of Armageddon with new terrain kits.
Evaluating the robustness and readiness of large frontier models in health AI applications
Nature Medicine - Adversarial evaluation of leading AI models uncovers gaps between benchmark success and robustness, highlighting limitations in current health AI benchmarks and their ability to...
Need for bread | Unexpected closure of Terranetti's Bakery has left several businesses scrambling
Terranetti's Bakery closes, and local shops are scrambling for bread
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
How many professional sports teams are in Austin?
With all the buzz around bringing more professional sports teams to the metro area, it’s worth considering how many are already here.
Prime Day ends soon: We found 125+ deals from Apple, Lego, Sony, Kindle, and more
Kindle e-readers, Apple Watches, and Samsung TVs are all highlights on day three of the Amazon sale.
Trump’s fixation on election overhaul bill derails GOP agenda on Capitol Hill
A nasty feud over President Donald Trump’s elections overhaul push has further crippled an already-dysfunctional Congress, leaving Republicans unable to move on critical elements of their agenda.
Adidas’ NIL pipeline is producing NBA rookies who already know the business
Mikel Brown Jr. reached the NBA with a head start few rookies have. Long before being selected sixth overall by the Brooklyn Nets at Tuesday’s NBA Draft, the 20-year-old guard had been embedded in Adidas’ ecosystem through a name, image and likeness deal that began in high school. “By the time our athletes walk across […]
From The Sports Desk: Is the Tartan party over?
Scotland’s hopes of advancing to the knockouts hang by a kilting thread.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Bungie Hit With Widespread Layoffs As ‘Destiny 2’ Ends And ‘Marathon’ Continues
Destiny 2's end has led to inescapable layoffs at Bungie, which are beginning today as the rest of the studio will now work on Marathon.
How Elifin is reshaping the commercial real estate playbook
Elifin is leveraging a decade's worth of proprietary commercial real estate data as well as artificial intelligence to reshape how properties are marketed, analyzed and sold. The Baton Rouge-based … Already an INSIDER? Sign in. Already an INSIDER? Sign in
Comcast's Sky to Buy ITV's Media and Entertainment Unit for $2.1 Billion
Comcast-owned Sky Group has reportedly agreed to acquire the media and entertainment business unit of U.K.-based ITV for $2.1 billion. The deal is expected to be officially announced in two weeks. Satellite operator Sky will absorb ITV’s broadcast network, linear free-to-air channels, and the ITVX subscription streaming service with 900,000 paid subscribers and 16.4 million … Continue reading "Comcast’s Sky to Buy ITV’s Media and Entertainment Unit for $2.1 Billion"
Former New Orleans Saints receiver Joe Horn ready for induction into Louisiana Sports Hall of Fame
"All the accolades that come behind my career and my work, I'm very humbled by it all"
York County restaurants scrambling for bread after bakery's closure
Terranetti's Italian Bakery in the Mechanicsburg area closed suddenly after 54 years, leaving York County restaurants scrambling for bread.
Byram says he’s ready for new opportunity as the top defenseman for Blackhawks
Bowen Byram is stepping in as Chicago’s No. 1 defenseman after he was acquired in a trade with the Buffalo Sabres on Tuesday night.
Revisiting the Politics of Indigeneity in Latin America
CDDRL Research-in-Brief [4-minute read]
Ball State Teacher Preparation Programs Earn Top Ratings in Science of Reading Reviews
Ball State University’s elementary education, early childhood education, and special education teacher preparation programs have earned top marks in two reviews focused on how well future educators are prepared to teach reading through evidence-based, scientifically grounded instruction.
Around the MHS
This edition of news from around the Military Health System for the week of June 22-26, 2026, includes a vital partnership between Offutt Air Force Base and the American Red Cross, new Uniformed Services University research on stress fractures, and Naval Medical Research Unit EURAFCENT participates in a multinational readiness exercise.
iPhone Ultra 2 already given go-ahead, iPhone Air 3 not, says leaker
We may still be waiting for the launch of the iPhone Ultra, but a leaker with a decent track record...
Vote in our L.A. Sports Hall of Fame (other sports edition)
Introducing the L.A. Times Sports Report Hall of Fame, where readers vote for Hall of Famers in various categories.
Scientists have just unlocked the secrets of an ancient scroll torched by Mount Vesuvius
After a centuries-long struggle, scholars managed to read five feet of text, using machine-learning methods they hope can unlock further discoveries.
Prime Day is here: We found 100+ deals from Apple, Lego, Sony, and more
Kindle e-readers, Apple Watches, and portable power stations are all highlights as we wrap day two of the Amazon sale.
‘Long-term Thinking Is Key To Ensuring Cultural Relevance’: Q’s With Gadget Entertainment Group’s Stefan Wyss
Gadget is one of Switzerland’s longest-standing promoters, having celebrated its 30th anniversary in 2024. In 2020, after already collaborating successfully
The Painting That Is Still on Trial in South Korea: How the unending Korean War became a permanent excuse to criminalise expression
By Boram Jang, East Asia Researcher at Amnesty International In a Seoul courtroom in March this year, a prosecutor read out charges against Jeon Seung-il, a former art student, from an indictment first written in 1989. The language had not changed, nor had the charges. Thirty-seven years later, only the young defendant had grown old. In 1989, he was 23 years old in a South Korea still shaped by decades […]
We finally have an opening date for the California Science Center’s space shuttle–centric expansion
Space Shuttle Endeavour is in place, and the Samuel Oschin Air and Space Center is (almost) ready for takeoff.
Rubio reassures Gulf allies as US-Iran talks advance
Tehran has already portrayed the deal as a victory
Game #80: A’s at Giants Game Thread
A’s Look to Snap Losing Streak
WATCH: Palmetto Sports Team LIVE at Greenville Drive’s “Game Show Night”
The Palmetto Sports Team gets ready for the Greenville Drive’s “Game Show Night” with a look at the Hot Dog of the Homestand and the help of mascot Reedy Rip’It and Drive host JDew.
Pa. measles cases jump, spread to Northumberland County
An unprecedented measles outbreak in the state has spread to an additional county, the Pennsylvania Department of Health announced Wednesday. Health officials...
Washington Nationals vs Philadelphia Phillies Game Thread
Follow along as the Nats look to bounce back from yet another heartbreaking loss where the bullpen imploded
Smoky skies prompt health advisories in Colorado’s mountains as wildfires balloon across the West
A haze from out-of-state wildfires is choking the Colorado mountains as widespread drought and persistent hot, dry weather continue to elevate the fire danger. The smoke wafting across the Western Slope is primarily from three...
On Main: When is downtown Concord ‘open for business’?
The Concord Monitor compiled an inventory of the storefront spaces on and around Main Street, categorizing them by type, noting businesses' tenures, hours and landlords. This data was used to build an interactive rendering of Main Street, where readers can pinpoint a day and time and simulate a stroll downtown.
Gas prices, health, quality of life drive push for more Coloradans to trade four wheels for two, even if safety is a worry
Bike to Work Day brings out the cyclists in Denver, but many already pedal to their jobs and back.
The 17 best popular science books of 2026 so far
The first six months of the year have brought us popular science reads on everything from consciousness to cosmology. Liz Else rounds up her favourites
First look at the Endeavor Space Shuttle at the California Science Center
Science fans will soon get the chance to see the Space Shuttle Endeavor in its ready-to-launch position at the California Science Center in Exposition Park this November.
Celebrating the Science of Reading Award
"Our school district leaders and teachers deserve tremendous credit for this achievement and their continued commitment to improving literacy skills."
The Rockefeller University » Campus book club examines the intersection of science and imagination
Avid readers at Rockefeller University have launched a book club that gathers every month to discuss a work of sci-fi.
Men’s Health: Caring for the Body, Mind and Spirit
FORT POLK, La. — Seeking help is often viewed as a vulnerability in military culture, but healthcare providers at Bayne-Jones Army Community Hospital are reframing it as a tactical strength. In observance of Men's Health Month, a BJACH family physician, a mental health provider and the hospital chaplain have partnered to deliver a unified message: peak military readiness requires actively maintaining the body, mind and spirit. From utilizing routine screenings to leveraging physical discipline to build mental resilience and cultivating a strong spiritual community, the team outlines actionable steps to overcome the physical, emotional and isolation barriers that uniquely impact men.
Scientists discover hidden “footprints of death” that may help viruses spread
Scientists have uncovered a surprising new twist in what happens when cells die. As dying cells break apart, they leave behind tiny “footprints of death” packed with newly discovered particles that help guide the immune system to clean up the remains. But researchers found that influenza viruses can exploit this process, hiding inside these microscopic packages and potentially using them to spread to nearby cells.
France confirms first Ebola case in doctor returning from DR Congo
The patient is in isolation, following strict biosafety protocols to prevent risk of spread in France.