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I treasure the moment I fell in love with sport as dearly as a first kiss
On Friday, August 26, 1988, England’s floppy-hatted wicketkeeper Jack Russell made 94 in a Test match against Sri Lanka at Lord’s.
Central Ohio coffee business fights to keep brewing after farm issue cuts yield
A coffee business rooted in culture and tradition is facing a critical moment.
Bronny, LeBron James share special on-court moment for Lakers
The family had to be happy about this one.
The hunt for the next UNC men's basketball coach begins
Davis' handling of key moments in games and the era of NIL contributed to the change at the University of North Carolina.
CDC's acting chief promises a return to stability in a tumultuous moment
Triad Business Journal Names Two Alumnae 2026 Outstanding Women in Business
Alumnae Shawanna Nicole Moore-Geter and Jamilla Pinder are among 25 honorees named Triad Business Journal’s 2026 Outstanding Women in Business.
Northwestern hires Princeton's Carla Berube as women's basketball coach
Carla Berube won 83.5% of her games at Princeton and went to five consecutive NCAA Tournaments. Now, she'll rebuild in the Big Ten at Northwestern.
Denver’s forgotten trailblazers: The Colorado Xplosion’s lasting impact on women’s sports
The first professional women’s sports team in the Mile High City, the Colorado Xplosion, was short-lived but not forgotten.
Greenville women’s health clinic closing after nearly 40 years
Physicians East announced that Greenville Women’s Care, located on Stantonsburg Road, will close on June 1, 2026.
Democrats' win in Trump's 'backyard' is another sign of midterm momentum
"If Democrats can win in Trump’s backyard, we sure as hell can win anywhere across the country," DNC Chair Ken Martin said on social media.
Amendment 50: Physical Sciences: Research Studies Not Solicited in ROSES-25
The NASA Physical Sciences (PS) program is part of the Biological and Physical Sciences Division. This program element will investigate physical phenomena in
Women’s lacrosse top 10 talk: Week Seven
Not much movement at the top, but contenders lurk in the lower parts of the top 10.
READY, SET, IMPLEMENT! Lifelines in Crisis: Prioritizing Women’s, Children’s, and Adolescents’ Health in Humanitarian, Conflict and Climate-affected Settings
This dialogue is part of PMNCH’s Ready, Set, Influence series, bringing together policymakers, humanitarian leaders, donors, and grassroots experts. The webinar will focus on accelerating the implementation of health commitments within humanitarian affairs, specifically focusing on the need for integrated, rights-based health services that remain resilient in the face of conflict, disaster and climate events.
How Weight Training Helps Women Through Hormonal Changes
The hormonal changes women undergo throughout their lives can affect muscle and bone health. Menopause, for example, dramatically speeds bone loss, with
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Four from Greater Grand Forks on Top 25 Women in Business list
Prairie Business contest honors exceptional professionals in the region
EQB welcomes Daniel Rethazy as EVP, Personal Banking, adding top banking talent to reignite core business growth and execute on transformation
EQB Inc. (TSX: EQB) today announces Daniel Rethazy's appointment as Executive Vice President, Personal Banking. Mr. Rethazy brings deep experience in Canadian Banking to EQB that will accelerate momentum and unlock a new era of growth for the company's Personal Banking franchise, delivering a more competitive and rewarding banking experience, and a stronger and more resilient banking industry for all Canadians.
Professor motivates students to nurture their inner entrepreneur
Mercer University professor Dr. Briana Stenard approaches teaching with a spirit that demonstrates that the best learning prioritizes confidence and ingenuity.
CEO Letter to Shareholders 2025
Dear Shareholders, 2025 was a remarkable year for Amer Sports and our teammates, partners, and shareholders. It gives me great pleasure to share with you some winning moments from the last 12 months…
RPI Athletics Celebrates 50 Years of Women's Sports
Rensselaer Polytechnic Institute proudly celebrates 50 years of women's varsity athletics—a milestone that reflects decades of progress, achievement, and opportunity for generations of student-athletes. What began as a commitment to expanding access in intercollegiate athletics has grown into a vibrant and competitive tradition that continues to shape the RPI community today.
Day in the life of Liz Plosser; former Women's Health editor-in-chief
Liz Plosser, the former editor-in-chief of Women's Health, starts her day with a precise alarm and has a tinned fish wrap for lunch every afternoon.
WNBA's labor deal is a structural shift for women's sports
America's top women's basketball league just agreed to a new CBA. It will have a significant impact on women's sport.
Black-Jewish Entertainment Alliance Freedom Seder to Return at Critical Moment
“The goal of the Freedom Seder isn't that everyone agrees, it's more that everyone leaves feeling heard and with a deeper understanding of one another.” – Bianca Tomash
'Beast' McTominay hailed for Napoli turnaround
"Beast of an athlete" Scott McTominay has been praised for the way he has gone from Manchester United "scapegoat" to Napoli great. Scotland assistant coach Steven Naismith revealed he had been impressed from the moment the 29-year-old midfielder joined the national squad.
Women’s Month Weekly: There’s never been a better time to be a girl in sports
With the influx of audiences now drawn to women's sports, younger girls are growing up in an environment that celebrates them.
Conservatives gather for CPAC with the right openly divided over the Iran war
Conservatives are holding one of their largest annual gatherings as President Donald Trump faces a tough moment and a growing rift over the war in Iran
Women's game needs more respect
Chelsea manager Sonia Bompastor says the women's game needs "more respect" after her side have a goal controversially disallowed in their Women's Champions League quarter-final first leg against Arsenal.
Victor Wembanyama, surging Spurs face depleted Grizzlies
The San Antonio Spurs are building momentum as the season winds down, a push that is putting pressure on Western Conference leader Oklahoma City.
Paul George ready to be 'the focal guy' for shorthanded 76ers upon return from suspension
George apologized Tuesday for his failed drug test and how it affected his team's momentum
Scientists Reflect on Experiences Meeting Patients
On the very best days, our researchers get to connect face to face with patients and families. Learn more about the meaning behind these moments.
Democrats’ long-shot bid to flip Alaska’s Senate seat
Democrats are hoping for an upset in Alaska’s Senate race. U.S. Rep. Mary Peltola, a Democrat, is trying to unseat Republican incumbent Sen. Dan Sullivan. We discuss the major issues at play, plus why Republicans are backing an effort to repeal Alaska’s ranked-choice voting system.This episode: voting correspondent Miles Parks, senior political editor and correspondent Domenico Montanaro, and Alaska Public Media Washington correspondent Liz Ruskin.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye.Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.
UT Health San Antonio Multispecialty and Research Hospital treats first clinical trial participant in novel cancer study - UT Health San Antonio
Milestone paves the way for advancements in cancer care, innovation and patient care in San Antonio and South Texas. UT Health San Antonio Multispecialty and Research Hospital has enrolled and treated its first clinical trial participant in a novel cancer study, marking a pivotal moment for science and patient-centered cancer care in San Antonio and […]
Pop-up bar dedicated to women's sports now open in Boston
261 at Para Maria is named for the bib number worn by the first woman to officially run the Boston Marathon.
Women-owned shops in Montgomery County bring variety to local business scene
In honor of Women's History Month, the Valley Forge Visitors and Convention Board puts the spotlight on a few of the many women-owned businesses in the county. From a cheese monger in Skippack at the Grand Fromage to Ardmore shop Plant 4 Good and Cyrenity Sips Winery in Hatboro.
Addressing Concussion Risk and Recovery for Women in Sports
Heather P Adams, MPAS, PA-C, discusses why women in sports may face higher concussion risks and longer recovery times than men.
Meet the 2026 Influential Women in Business and see the Women’s Leadership Symposium lineup
They run hospitals, build companies, fight cancer and welcome visitors to the Capital Region. Now, nine of the area’s most accomplished women are being recognized as 2026 Influential Women in Business by Baton Rouge Business Report. The honorees will be recognized May 19 at the Influential Women in Business Luncheon, which follows the fourth annual […]
Kaus Earns College Sports Communicators Academic All-District Honors
ITHACA, N.Y. – Cornell women's basketball junior Rachel Kaus has been named to the College Sports Communicators (CSC) Academic All-District team, the organization announced on Tuesday.
G7 Entertainment Marketing Launches Wild by G7 to Help Destinations Turn Culture Into Travel Demand
New Venture Responds to Surging Demand for Experience-Driven Travel by Helping Destinations Create Cultural Moments that Drive Visitation, Economic Impact, and Brand Loyalty Wild by G7 is producing the Rendezvous Music Festival The Head and the Heart band performed at a past Rendezvous Music Festival in Jackson, Wyoming Wild by G7 Sizzle NASHVILLE, Tenn. and JACKSON, Wyo., March 24, 2026 (GLOBE NEWSWIRE) -- G7 Entertainment Marketing, the experiential and talent booking agency behind campaigns f
Gender equality in science: a distant goal; invisible barriers persist
While the number of women in scientific organisations is increasing, the path towards true equality is slowed down by structural barriers and informal processes
Stony Brook Southampton Educators Earn Suffolk County Recognition for Science, Sustainability and Service
Suffolk County Legislator Ann E. Welker recognized educators from Stony Brook Southampton during the March 10 general meeting of the Suffolk County Legislature and the Women of Distinction luncheon, both held in Riverhead, NY. Wendy Pearson, vice president for strategic initiatives at Stony Brook University and executive director for Stony Brook Southampton, received a 2026 Woman
Brown Named College Sports Communicators Academic All-District
Guard Malea Brown of the Longwood women's basketball team has been named to the 2025-26 Academic All-District® NCAA Division I women's basketball team as selected by the College Sports Communicators, the organization announced Tuesday.
Three Hawks Named to College Sports Communicators Women's Basketball Academic All-District Team
WEST HARTFORD, Conn. - On Tuesday, the College Sports Communicators (CSC) Academic All-District women's basketball teams were announced with three members of the Hartford volleyball team featured.
4 Pitt people were named Pittsburgh Business Times 2026 Women of Influence
The awards recognize the region’s businesswomen, including one Pitt dean and three alumnae, who make impactful change by leading organizations.
Health Care Access for Women: The Cost of Being Dismissed, March 26
The event will feature a panel and table discussions focused on strategies for women to more effectively advocate for themselves in health care settings.
Six Panthers selected to College Sports Communicators Basketball Academic All-District Teams
CEDAR FALLS, Iowa --- Six members of the UNI men's and women's basketball teams were recognized by College Sports Communicators (CSC) with Academic All-Distr...
Arlington's Westover Taco Will Be Home to Northern Virginia's First Women’s Sports Bar
Restaurateur Sarah White is converting Arlington's Westover Taco into Northern Virginia's first ever women's sports bar.
Investigating how women living at the margins of formal health systems
Scholar-Elect Sara Jane Renfroe talks about her work on gender rights and access to healthcare for marginalised groups ahead of her PhD in Social Anthropology.
March Madness top seeds dominate: Each No. 1 team's path to Sweet 16
Only one perfect 2026 Women's NCAA Tournament bracket remains as of Monday evening following several upsets, but the top seeds have been chalk.
Women's NCAA Tournament Round 2 winners, losers: Virginia make history, Iowa fizzles
USA TODAY has followed every upset, buzzer-beater and game from the 2026 Women's NCAA Tournament and rounded up our winners and losers from round two:
From data to culture: Baptist Health’s well-being journey
A defining moment became a catalyst as Baptist Health strengthened leadership engagement, secured local champions to expand physician support across Kentucky.
Russia in Africa: Inside the alleged operation to influence Angolan politics
A group of Russians and Angolans are going on trial in Angola after being accused of fomenting protests, which they deny.
Aramark Sports + Entertainment’s Culinary Creativity Takes the Field at Eight MLB Stadiums as Umpires Shout “Play Ball!”
As Major League Baseball prepares to welcome fans back for another season of unforgettable moments, Aramark Sports + Entertainment (Aramark; NYSE: ARMK) is stepping up to the plate with a new lineup of culinary innovations, collectible souvenirs, and fan‑driven experiences debuting across eight MLB stadiums nationwide.
Revolutionary Women: Lady Johnson, Angelica Schuyler and the Politics of Loyalty
State and territory commissions and other partners are hosting events across the nation to commemorate America's 250 anniversary in 2026.
It’s a Chaotic Moment in America. That’s Not What Republicans Need.
A national mood of unease and anxiety ahead of major elections is rarely good for the party in power.
I was on the Air Canada flight that crashed at LaGuardia
A 22-year-old student was on an Air Canada flight that crashed at LaGuardia Airport. He described the moment of the collision and the aftermath.
Science Through Shadows: How Astronomical Alignments Reveal the Universe
When one celestial object passes in front of another, it can cast a shadow that travels across space – and sometimes across Earth. These moments of alignment, known as eclipses, occultations, and transits, allow scientists to study distant objects in remarkable ways. By observing how light changes when an object briefly blocks another, astronomers can measure sizes and shapes, detect atmospheres, and refine the orbits of asteroids and planets.
NIH grant terminations affected women scientists more than men, study finds
A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations
Women's March Madness results so far: Scores from Monday's NCAA Tournament
Three No. 1 seeds are in action today as the Women's NCAA Tournament whittles the field down to the Sweet 16. See who's primed to survive and advance.
Mills, Collins on opposite sides of trans athlete issue
Collins, who is seeking a sixth term, posted on social media over the weekend that she’s held a “longstanding position that transgender athletes should not compete in girls’ and women’s athletics.”
Expanded NICU offers families privacy, innovation
The NICU at Temple Health's new Women and Families Hospital offers twice the space and many more services than its predecessor.
F1 CEO talks US growth as business accelerates
Formula One (F1) CEO Stefano Domenicali joins Yahoo Finance Executive Editor Brian Sozzi to discuss F1's rapid growth in the US market, new racing regulations, and more. Watch the video above to hear more on the sport's focus on expansion and entertainment.
Women's March Madness live updates, scores, results: Alabama leads Louisville in tightly contested first half; UConn, South Carolina, UCLA back in action Monday
Antarctica could warm 1.4 times faster than the rest of the Southern Hemisphere in the coming decades, study finds
Antarctica could warm much faster than its surroundings over the next few decades due to a phenomenon known as polar amplification that is well established in the Arctic.
Caesars Entertainment (CZR) Valuation Check After Recent Share Price Recovery
Caesars Entertainment stock overview Caesars Entertainment (CZR) has been drawing attention after recent share price moves, including a gain over the past month. This has prompted investors to reassess how its current valuation lines up with recent financial results. See our latest analysis for Caesars Entertainment. Recent trading has been choppy, with a 26.05% 1 month share price return contrasting with a 4.87% decline in 1 year total shareholder return. This signals momentum building in...
Finishing a video game can trigger “post-game depression,” study finds
Post-game depression is now being studied as a measurable phenomenon, with researchers identifying how finishing a video game can leave players feeling empty, reflective, and emotionally drained.
Happening this week | Women Working and Winning in Politics Roundtable
The 3rd annual Women Working & Winning in Politics Roundtable will be held at Dillard University
Small Business Promotion Week: Hey Honey Marketplace
Jennifer Reeves, nurse turned boutique owner, came up with the idea for Hey Honey Marketplace, a boutique on Abram Street that aims to not just be a store but a community gathering place for women.
Illinois, the youngest team in Women's NCAA tournament, proving age is just a number
No. 7 seed Illinois faces No. 2 seed Vanderbilt in Nashville in the second round of the Women's NCAA Tournament.
Closing the women’s health gap: 5 key focus areas and why they need more research
Only 6% of private investment targets women's health, a World Economic Forum report says. 5 examples show how strategic investments could change this.
Vanderbilt’s historic gym takes center stage for Women's NCAA Tournament
Opening in 1952, Memorial Gymnasium is the oldest arena in the SEC. It had been 14 years since the Commodores last hosted the NCAA Tournament.
Women’s health innovation is a huge opportunity Philadelphia is in danger of missing
A booming medical market is creating jobs, research and startup funding, and the region has the talent and institutions to become a national leader, a local entrepreneur writes.
Meet CT’s 2026 Women in Business honorees
Hartford Business Journal’s 2026 Women in Business awards recognize top leaders who are making a significant difference within their organization and the broader community.
German men's biathlon coaches stay, women's coaches leave after flop
Tobias Reiter und Jens Filbrich have kept their jobs as coaches of Germany's men's biathlon team despite their equivalents in the women's team leaving their roles. The season which finished on Sunday was hugely disappointing for the former biathlon powerhouses, with just one Olympic bronze medal and no World Cup wins.
Ohio State vs Notre Dame predictions, picks, odds for NCAA Tournament Second Round
Our March Madness experts pick the winner for No. 3 Ohio State vs No. 6 Notre Dame in the 2026 women's NCAA Tournament on March 23
UConn vs Syracuse predictions, picks, odds for NCAA Tournament Second Round
Our March Madness experts pick the winner for No. 1 UConn vs No. 9 Syracuse in the 2026 women's NCAA Tournament on March 23
Where to watch South Carolina vs. USC in March Madness Second Round: Time, TV Channel
The No. 1 South Carolina Gamecocks face the 9 USC Trojans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.
Banijay Series Mania Slate: ‘A Woman of Substance,’ ‘Peaky Blinders’
Other highlights take in Jack Thorne’s ‘Falling,’ Richard Gadd’s ‘Half Man,’ ‘Wallander’ and Series Mania titles ‘Anatomy of a Moment’ and ‘Etty.’
Rising job opportunities in sports management attract students
Kaleb Tkacs became involved in sports management from the moment he stepped foot on Duquesne University’s campus in August 2023. Tkacs, of Scottdale, joined as a volunteer film crew member with the Duquesne football team that fall. In 2024, he was elevated as a student assistant, overseeing the film crew,
Best selling author Marie Benedict to talk at the United Theatre
WESTERLY — Marie Benedict, the Pittsburgh-based author known for using real — mostly forgotten — women as inspiration for her bestselling works of historical fiction, was on the phone Tuesday
Dr Liz O'Riordan: Women's health must be taken more seriously
Dr Liz O'Riordan says it is important women seek help from professionals not "Google and Chat GPT".
TCU completes comeback, avoids Washington's NCAA Tournament upset bid
TCU women's basketball’s 62-59 overtime win over Washington in the second round of March Madness wasn’t pretty, but it was resilient.
Socialist Emmanuel Grégoire elected Paris mayor in runoff vote
Emmanuel Grégoire has won the Paris mayoral race and takes over from fellow Socialist Anne Hidalgo. On Sunday, he sealed the moment by riding a city bike to City Hall.
NCAA women's tournament takeaways, Day 3: Minnesota drains buzzer-beater as LSU, Texas dominate again
Women's March Madness live updates, scores: LSU makes history in NCAA tournament; Minnesota stuns Ole Miss to advance to Sweet 16
Notre Dame men join women in winning inaugural three-weapon title
Notre Dame's Ahmed Hesham won the men's saber Sunday, and the Fighting Irish men joined the women in winning the inaugural three-weapon national championship at the Joyce Center.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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