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PHOTO GALLERY: Cardiac surgery technologies at the AATS 106th Annual Meeting
A wide variety of technologies, including robotic systems, heart valves, stent grafts, retractors and annuloplasty rings, were on display in Chicago.
Heart experts concerned after Trump administration authorizes fruit-flavored e-cigarettes
This is the first time the FDA has authorized market access for non-tobacco, non-menthol electronic nicotine delivery systems.
Resilia tissue developed by Edwards Lifesciences associated with long-term durability
Kevin Accola, MD, spoke to Cardiovascular Business about new 10-year data on the performance of surgical valves featuring Resilia tissue. The findings are good news for Edwards Lifesciences, which also includes the tissue on many of its TAVR devices.
Cannabis use increases risk of death, heart attack for ED patients
When patients land in the emergency room, a history of cannabis use may increase their risk of an adverse outcome.
SCCT President: Key trends in cardiac CT
As CCTA sees rapid adoption across cardiology, SCCT is working to address the education required to sustain the expansion.
Impella 5.5 shows promise in certain non-shock, high-risk cardiac surgery patients
New data out of the AATS Annual Meeting identified significant potential for a new treatment strategy.
First patient enrolled in massive heart failure trial
Data from BENEFIT-HF, a new randomized study of CVRx's implantable Barostim device, could open up access to many more heart failure patients.
TAVR or SAVR? Cardiologists and heart surgeons highlight the care that goes into each decision
When heart patients require aortic valve replacement, would they be a better fit for TAVR or SAVR? Such decisions are not made lightly, clinicians emphasized in a new joint statement.
FDA details Class I catheter recall due to safety risk
The FDA first shared a warning about this issue back in April. Now, the agency has shared a critical update.
Advanced AI helps 3D imaging labs evolve with the times
“Technology grows and grows,” as one lab director explained. “Our job is to keep up with it and use it in the most efficient and effective way.”
Surgery still outperforms GLP-1 drugs in terms of heart health
Both treatment options are effective, but metabolic and bariatric surgery was linked to more significant cardiovascular risk reductions than GLP-1 medications.
Heart Rhythm 2026: Electrophysiologist Mina Chung discusses CPR, PFA and much more
Mina Chung, MD, who just concluded a one-year term as Heart Rhythm Society's president, spoke to Cardiovascular Business about successes from the past year as well as her goals for the future.
Johnson & Johnson to acquire Atraverse Medical
The move, once finalized, helps Johnson & Johnson add multiple FDA-approved technologies to its EP portfolio.
Doctors agree: There’s a lot to love about cardiology’s future
According to a new survey, both cardiologists and noncardiologists feel good about the specialty's long-term health.
Women live longer after TAVR than men
Researchers tracked real-world data from 600 TAVR patients, following each one for approximately five years. Survival rates were similar for men and women early on, but then women started experiencing better outcomes after three years.
FDA approves next-gen mitral valve from Medtronic
The Mosaic Neo mitral bioprosthesis can be implanted through sternotomy, minimally invasive cardiac surgery or robotic access.
PFA's dominance and other key electrophysiology trends on display at Heart Rhythm 2026
Heart Rhythm 2026 Program Chair DJ Lakkireddy, MD, spoke to Cardiovascular Business during the conference about several key EP trends.
Virtual nursing staff may help save cardiology departments from burnout
The idea is started to spread thanks to a new startup focused on providing much-needed relief to cardiologists.
Cleveland Clinic Establishes Space Health Center
Center aims to broaden research, education and clinical care addressing cardiovascular health conditions related to space travel
IV fluids recalled over possible contamination—patients face risk of vascular complications
Particulate matter may be present in certain 1-liter containers of B. Braun Medical's Lactated Ringer's Injections. If this enters a patient's circulatory system, it could lead to a series of adverse events.
FDA warns public about vascular device after 3 deaths
The FDA is still investigating this issue. For now, the agency recommends considering alternative treatment options when possible.
How to implement AI-powered coronary plaque analysis software—and ensure you get paid
The use of AI to evaluate plaque buildup in CCTA images has been one of cardiology’s biggest ongoing trends. Implementing this software into existing workflows, however, can be a challenge. An upcoming webinar is focused on providing guidance to hospitals and cardiology practices hoping to learn more about this topic.
Abbott gains FDA clearance, CE mark approval for AI-powered imaging platform
Ultreon 3.0 was built to capture and evaluate high-quality OCT images, providing real-time guidance during complex PCI procedures.
Brain Health Across the Life Span: A Framework for Future Studies
This Scientific Statement focuses on the role of nonvascular physical and psychological factors that impact brain health, which is described as the optimal functioning of the brain across cognitive, emotional and behavioral domains throughout life.
New SCAI President Dawn Abbott outlines workforce, training and inclusion priorities
SCAI President Dawn Abbott, MD, MSCAI, aims to turn attention toward the long-term sustainability of the interventional cardiology field.
Boston Scientific pacemakers recalled again—software update now available
The new Class I recall, which includes more than 1.4 million devices, is related to an issue first announced back in 2024. Updating the software should address the issue going forward, though some patients may still require an early replacement.
Fewer stents, positive outcomes: Sirolimus-eluting balloons a safe alternative during PCI
Using a DCB that releases sirolimus over an extended period of time appears to be both safe and effective when treating patients who present with NSTEMI or unstable angina.
Multiple GLP-1 drugs linked to lower AFib risk
The popular drugs, originally developed to treat diabetes, were also associated with an improved survival rate. Benefits were seen in patients who did and did not lose significant weight as a result of treatment.
As heart, kidney and metabolic health worsen, cancer risk may rise
Research Highlights: Researchers studied the link between cardiovascular-kidney-metabolic syndrome (CKM syndrome) and risk of cancer. CKM syndrome refers to several connected health conditions, including heart disease, stroke, kidney disease, obesity...
Super Bowl champion quarterback talks about how AI is revolutionizing the way we look at heart health
Super Bowl champion Steve Beuerlein talks to Fox News Digital about how AI has helped him be proactive about his cardiovascular health.
Popular weight loss drug linked to key benefits for patients undergoing TAVR, PCI
Two separate studies explored the value of treating heart patients with tirzepatide.
‘Father of modern cardiology’ Eugene Braunwald dies at 96
Colleagues from all over the world have shared loving tributes to Braunwald. ESC President Thomas F. Lüscher, MD, called him "the pioneering cardiologist of his time."
Mechanohealth: Where life science meets physical forces for health innovation
Integrating mechanobiological principles into disease pathogenesis, therapeutic development, and tissue engineering is reshaping our understanding of biological systems and accelerating the advancement of mechanotherapy and mechanohealth. This field reveals how mechanical cues regulate cellular behavior, such as force transmission along integrin-nucleus pathways and collective cell migration, and tissue functions. In doing so, mechanobiology connects fundamental research with clinical applications, from limiting cancer metastasis and fibrosis to promoting bone regeneration and maintaining vascular homeostasis. Building on discussion from the Inaugural International Conference on Mechanobiology (ICM) 2025, integrating mechanobiological research with clinical strategies offers new opportunities to address unmet needs, including personalized anti-fibrotic interventions or precision bone regenerative therapies. At the same time, it supports the broader concept of mechanohealth -- a paradigm focused on preserving the physiological mechanical balance within tissues.
Delaware nurse practitioner raises awareness and funds to end women’s No. 1 health threat
NEWARK, Del., April 20, 2026— While the large majority of cardiac events can be prevented, cardiovascular disease (CVD) continues to be the leading cause of death in women.[1] In recognition of her energy and passion to fight back against women’s...
It doesn’t matter how much you sit — walking more could lower your risk of death and disease
Sitting all day might not be as damaging as once feared—if you’re willing to move more. A massive study tracking over 72,000 people found that simply increasing daily steps can significantly reduce the risk of death and heart disease, even for those who spend long hours sedentary. Hitting around 9,000–10,000 steps a day delivered the biggest benefits, cutting mortality risk by nearly 40% and cardiovascular disease by over 20%.
Beyond the Dialysis Machine: Shaping the Future of Kidney and Cardiovascular Health
At Yale School of Medicine, Christopher El Mouhayyar, MD, works at the forefront of managing dialysis treatment in patients while addressing underlying disease.
Heartflow sues cardiology AI rival Cleerly over alleged patent infringement
According to Heartflow, Cleerly's actions represent “one of the most egregious examples of piracy in the medical technology industry.” Cleerly commented on the lawsuit, defending the value and integrity of its products.
Stryker enters competitive IVL space with acquisition of Amplitude Vascular Systems
Stryker, one of the world’s largest medtech companies, has agreed to acquire a rising name in the field of intravascular lithotripsy.
FDA shares warning about cath lab procedure kits due to risk of patient injury
The syringes included in several convenience kits commonly used by interventional cardiologists and interventional radiologists should not be used. If treatment is necessary and no other devices are available, it should be done with “extreme caution and vigilance.”
3 diet tweaks heart health nutrition scientist made to prevent disease
How quickly and when you eat could affect your metabolic and cardiovascular health, professor Sarah Berry said.
SVS quality initiative gathers data to improve vascular care
More than 7,000 physicians from a wide variety of healthcare specialties are already participating in the project.
The lifesaving catch that changed everything
Javon Brumsey's lifesaving catch saw him take on heart surgery and recover with the ECU Health Cardiovascular and Pulmonary Rehab program.
New gene therapy may help protect the hearts of patients with Friedreich's ataxia
A majority of deaths from Friedreich's ataxia are associated with heart complications. A new treatment years in the making could provide some much-needed relief.
A night of two national titles for U-M, as scientists and basketball players both triumph
On the same night that the U-M men's basketball team triumphed in the NCAA tournament, U-M cardiovascular researchers won a national tournament of science
Arizona cardiology practice paying $3.85M to resolve lawsuit after data breach
The 2023 incident potentially gave an attacker access to the names, addresses and Social Security numbers of thousands of heart patients.
Young Adults With High Blood Pressure Face Higher Risk of Heart, Kidney Disease
Recent research suggests that adults ages 30 to 40 with high blood pressure may face a higher risk of cardiovascular and kidney disease later in life. These findings highlight the importance of maintaining a healthy blood pressure at a younger age.
Migration can influence cardiovascular risk profiles, study shows
A new study shows that migration from Mexico to the United States can influence cardiovascular risk profiles. The study's findings are important for clinicians who serve immigrant populations and who ...
Iterative Health, US Heart & Vascular Partner to Advance Community-Based Cardiovascular Research
April 2, 2026 — Iterative Health and US Heart & Vascular (USHV) have announced a strategic partnership to advance research through community-based innovation in cardiovascular care. "Clinical research is one of the most powerful ways we expand access, improve patient outcomes, and shape the future of cardiovascular care," said Robbie Allen, chief executive officer of US Heart & Vascular. "By partnering with Iterative Health, we are strengthening our ability to bring innovative therapies directly into the communities we serve. This collaboration ensures our physicians and patients have access to leading-edge trials while allowing US Heart & Vascular to remain focused on delivering exceptional, physician-led care." Under the agreement, USHV research sites will join Iterative Health’s global site network, which now spans over 100 sites across three continents. The companies share a commitment to advancing clinical research as a driver of care innovation, and this collaboration represents a major milestone for both organizations, strengthening USHV's leadership in community-based cardiovascular research and expanding Iterative Health's multispecialty focus beyond GI, hepatology, and obesity into cardiology. USHV clinical research sites will gain access to Iterative Health's centralized operational backbone, providing end-to-end support across clinical research operations, services, business development, technology innovation, and corporate functions. The strategic partnership reduces operational complexity and unlocks growth potential for USHV research sites while enabling all USHV physicians to expand access to cutting-edge therapies to the thousands of patients they serve annually. "Innovation in cardiovascular medicine shouldn't be limited to a few academic centers," said Thomas Waggoner, DO, MD, RPVI, FACC, FSCAI, FSVM, RPVI, Structural Cardiologist and Medical Director for Clinical Research at Pima Heart & Vascular, and USHV Physician Champion for Clinical Research. "By expanding community-based research across USHV, we're ensuring more patients have access to clinical trials and breakthrough therapies close to home, where trusted relationships with their physicians already exist." This alliance reinforces Iterative Health's standing as the definitive research partner across specialized therapeutic areas, now spanning GI, hepatology, obesity, and cardiovascular care. Trusted by many of the nation's leading provider organizations and biopharma sponsors, Iterative Health's global site network delivers industry-leading trial performance, accelerating life-changing therapies to market at scale. "Entering cardiology through our strategic partnership with US Heart & Vascular is a defining moment for Iterative Health and reflects the strength of our site-serving model," said Jonathan Ng, founder and CEO of Iterative Health. "Together, we are ensuring that thousands of patients have access to the newest available therapies, and that sponsors have a credible, high-performing partner to accelerate cardiovascular trial success." For more information, visit www.iterative.health and https://usheartandvascular.com/.
Cardiovascular health in pregnancy according to Life’s Essential 8 score
npj Cardiovascular Health - Cardiovascular health in pregnancy according to Life’s Essential 8 score
UK HealthCare announces new director of Gill Heart & Vascular Institute
After an intensive national search and selection process, UK HealthCare leadership announced that Vedant Gupta, M.D., has been selected as the director of the Gill Heart & Vascular Institute and leader of the cardiovascular health service line.
Following 9 key steps for a lifetime of eating well can support heart health
Statement Highlights: Sustaining lifelong healthy eating patterns may reduce the risk of cardiovascular disease and other chronic health issues, according to the latest updated dietary guidance offered in a new scientific statement from the American...
Helen H. Hobbs, M.D., honored for innovation in cardiovascular science
Helen H. Hobbs, M.D., Professor in the Eugene McDermott Center for Human Growth and Development and of Internal Medicine and Molecular Genetics at UT Southwestern Medical Center, has been named the recipient of the 2026 Valentin Fuster Award for Innovation in Science by the American College of Cardiology (ACC).
Private equity is eying Asia’s healthcare funding gap as countries get wealthier and older
“Asia has more diabetes, cancer and cardiovascular patients than anywhere else in the world,” Abrar Mir, co-founder of Quadria Capital, says.
Sleeping 11 minutes longer each night shows surprising health benefit, study finds
New research finds that small daily habits, including 11 more minutes of sleep and extra vegetables, are linked to a 10% lower cardiovascular risk.
‘Practice-changing’ interventional cardiology research grabs ACC.26 spotlight
The second day of the American College of Cardiology’s annual conference started with a series of highly anticipated interventional cardiology trials.
Rural students get hands-on heart science experience
Jefferson County teacher Jasmine Change-Jones launched the 'Heart of Science' lab, giving rural students hands-on learning about cardiovascular health.
A nutrition scientist shared 3 food swaps for heart-healthy meals
Professor Sarah Berry, a nutrition scientist who specializes in cardiovascular disease, said getting the basics right can go a long way toward supporting our heart health.
Stopping GLP-1 drugs like Ozempic erodes heart health benefits quickly, new study finds
Stopping GLP-1 drugs like Ozempic quickly erodes heart protection, with two years off the medication raising cardiovascular risk by 22%, a new study finds.
NYC Health + Hospitals/Jacobi | North Central Bronx Brings Novel Minimally Invasive Vascular Surgery Procedures to the Bronx - NYC Health + Hospitals
NYC Health + Hospitals/Jacobi | North Central Bronx today announced it has begun offering two types of minimally invasive surgical procedures that were
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Early Menopause Linked to 40% Higher Risk of Cardiovascular Disease
Women who go through natural menopause before age 40 face a 40% higher lifetime risk of coronary heart disease. Black women are three times as likely to experience early menopause as white women.
Cycle Nova: Villanova students unite to honor a legacy and advance heart health
Villanova, Pa., March 17, 2026 — Beat for Good, Villanova University’s student‑run organization dedicated to supporting individuals and families affected by cardiovascular disease, hosted its inaugural cycling fundraiser, Cycle Nova, on Saturday, March...
New obesity statistics highlight importance of preventive cardiology
Cardiovascular health is much worse in some parts of the United States than others. Cardiologists in those high-risk areas can make a world of difference by embracing preventive cardiology and working to treat patients before it is too late.
Young men and heart health
The study revealed that men start developing cardiovascular disease years earlier than women, with cardiac risk differences beginning as early as their mid-30s.
Health Rounds: Death from dementia on the rise among people with type 2 diabetes
March 11 (Reuters) - In people with type 2 diabetes in the world's richest countries, deaths from cardiovascular disease are declining while mortality from dementia is on the rise, a large analysis ha...
Medtronic to acquire medtech company Scientia Vascular for $550M
Scientia Vascular, a Salt Lake City-based medtech company focused on developing new vascular devices, was founded in 2007 and has more than 300 employees.
Corpus Christi executive leaders spearhead local women’s heart health movement
CORPUS CHRISTI, Texas, March 3, 2026 — Cardiovascular disease (CVD) is the leading cause of death for women[1] in Corpus Christi and across the United States. To change that, the American Heart Association, a relentless force changing the future of...
Becker’s Hospital Review Names RWJBarnabas Health to 2025 “100 Hospitals and Health Systems with Great Heart Programs" List
RWJBarnabas Health has been named to Becker’s Hospital Review’s 100 hospitals and health systems with great heart programs for the third consecutive year in 2025. The hospitals, health systems and institutes recognized on this list are distinguished for their excellence in heart and vascular care.
Erectile dysfunction can signal heart disease in otherwise healthy men
Erectile dysfunction can indicate heart disease years before cardiovascular issues arise. In fact, most heart problems don’t even start in the heart itself.
Common Arthritis Drug Found To Lower Blood Pressure and Boost Heart Health
A widely used treatment for rheumatoid arthritis may offer an unexpected cardiovascular benefit. Methotrexate has been a staple treatment for rheumatoid arthritis for decades, valued for its ability to calm an overactive immune system and reduce painful joint inflammation. Now, researchers say it m
How Adderall affects the heart when you don’t have ADHD: a cardiologist’s warning
Students sometimes take unprescribed Adderall to stay up late and study. According to new research out of Mayo Clinic, however, that may do more to the heart than those students realize.
Why heart disease and stroke are expected to rise significantly among younger women
Obesity, diabetes and high blood pressure are fueling increases in cardiovascular disease, even among much younger women, the American Heart Association said.
The truth about fat, and its complex role in our health
To find out more about the complex role fat plays in our health, Ian Sample hears from co-host Madeleine Finlay and from Declan O’Regan, professor of cardiovascular AI at Imperial College London
The truth about fat, and its complex role in our health
To find out more about the complex role fat plays in our health, Ian Sample hears from co-host Madeleine Finlay and from Declan O’Regan, professor of cardiovascular AI at Imperial College London
Women suffer heart attacks too. Understanding risks and symptoms
More than 60 million women in the U.S. live with cardiovascular disease and about 37,000 die from heart attacks each year.
New cardiology-OB-GYN continuing education to launch with $1 million gift from leading media voice on health Dr. Jennifer Ashton and husband Tom Werner
Embargoed until 1pm ET, Monday, February 23, 2026 DALLAS, Feb. 23, 2026 — The American Heart Association today announced a bold new initiative designed to transform how clinicians identify and treat cardiovascular risk in midlife women. The...
Pecans found to improve cholesterol and boost heart health
A sweeping new scientific review suggests that pecans — America’s native nut — may pack more heart power than many people realize. After analyzing over 20 years of research, scientists found consistent evidence that eating pecans can improve key markers of cardiovascular health, including total cholesterol and “bad” LDL cholesterol, while also supporting antioxidant defenses.
Pecans found to improve cholesterol and boost heart health
A sweeping new scientific review suggests that pecans — America’s native nut — may pack more heart power than many people realize. After analyzing over 20 years of research, scientists found consistent evidence that eating pecans can improve key markers of cardiovascular health, including total cholesterol and “bad” LDL cholesterol, while also supporting antioxidant defenses.
The science behind exercise and why it's good for our bodies
This will come as a surprise to no one, but exercise is really good for us. But why it works and how it works are far less understood. Horizons moderator William Brangham explores that with Stanford University’s Euan Ashley. He's a professor of genomics and cardiovascular medicine and is part of a team trying to understand, at the very molecular level, how exercise changes our bodies, and why.
The science behind exercise and why it's good for our bodies
This will come as a surprise to no one, but exercise is really good for us. But why it works and how it works are far less understood. Horizons moderator William Brangham explores that with Stanford University’s Euan Ashley. He's a professor of genomics and cardiovascular medicine and is part of a team trying to understand, at the very molecular level, how exercise changes our bodies, and why.
Column | 8 science-backed habits for a healthier heart
People who focus on these things not only have better cardiovascular health, but are also protected against conditions such as diabetes, dementia and cancer.
Column | 8 science-backed habits for a healthier heart
People who focus on these things not only have better cardiovascular health, but are also protected against conditions such as diabetes, dementia and cancer.
From heart association volunteer to survivor, Louisiana woman champions cardiovascular health
Learn about Katie Ferguson, a heart disease survivor who champions awareness of women’s cardiovascular health.
Aurora woman shares heart health journey
February is American Heart Month, a time to raise awareness about cardiovascular health. FOX31 sat down with a local woman sharing her journey with decades of obstacles with her heart.
Building Your Heart Health: Questions and Answers About Cardiac Rehab
If you’ve had a heart attack or other serious heart event, there’s something that could cut your cardiovascular risk by nearly half, says Raquel Nodarse-Lara, RN, at Baptist Health Miami Cardiac & Vascular Institute.
Assessing Suzhou Ribo Life Science’s Valuation After Recent Share Price Weakness
Recent share performance and business profile Suzhou Ribo Life Science (SEHK:6938) has drawn attention after a 5.4% one day decline to HK$70.05, extending a one month return of a 7.9% decline and a year to date return of a 14.7% decline. For context, the company focuses on researching and developing small nucleic acid drugs targeting cardiovascular, metabolic, renal, liver and other diseases, with several candidates in Phase I, Phase II and preclinical trials. See our latest analysis for...
UAMS offers quick, noninvasive heart screenings during American Heart Month
American Heart Month is putting a spotlight on cardiovascular health, as heart disease remains the leading cause of death in the United States, accounting for n
CCTA becoming an essential tool for interventional cardiologists
Ziad Ali, MD, explains how coronary computed tomography angiography is creating a major shift in cardiac care.
American Heart Association's Go Red for Women movement raises awareness, funds for women's health
Cardiovascular disease (CVD) is the leading cause of death in women.
New heart catheter for cell therapy delivery 1 step closer to FDA approval
The BioCardia delivery catheter was designed to be used by interventional cardiologists, electrophysiologists or cardiac surgeons. It includes a tiny needle that directly engages with the patient’s cardiac tissue.
Essentia Health-St. Mary’s Medical Center welcomes Brittany Kuehn to practice vascular surgery
Brittany Kuehn, certified physician assistant practicing vascular surgery, is thrilled to join Essentia Health-St. Mary’s Medical Center.
2025 US ACT on Health Equity Community Investments Recipients
Author: Kennesha VanBurch, Director, Health Equity and Community Investment Partnerships 2025 marks the fifth year of the US Accelerate Change Together (ACT) on Health Equity: Community Solutions Challenge (CSC) and National Strategic Collaborations (NSC). This year, we received more than 250 applications from organizations across the country dedicated to prioritizing the social, cultural and linguistic needs of communities that have experienced barriers to care and opportunity. The overwhelming response underscores the vital role these organizations play in advancing health equity at the local level and across the nation. Since the launch of ACT on Health Equity in 2021, the initiative has invested more than $18 million in nonprofit organizations and their health equity programming through CSC and NSC. This year, $3.4 million in funding has been provided to 47 nonprofit organizations that focus on healthcare access, nutrition and lung health. Together, we are making meaningful progress toward health equity across the US. Supporting Organizations Advancing Community Well-being and Health Equity The awarded organizations address critical needs across health, education, and social support through initiatives aligned with AstraZeneca’s areas of expertise, including lung disease, lung and breast cancer, and cardiology. Their work spans across culturally competent senior care, equitable healthcare access, cancer and chronic disease support, and preventive health education, as well as hunger relief, community gardening, dental and transportation services, and resources for underserved families. Together, they are working to remove barriers to care, reduce preventable conditions, and empower individuals and communities of all ages and backgrounds to achieve better health outcomes. Photo courtesy of Medical Motor Service of Rochester and Monroe County, Inc. Description: MMS driver speaking to a Wegmans shopper. GGWNY staff; Lincoln Memorial Church Community Garden and lead gardener Diane Learn more about our recipients and the impact they make within their communities below. Community Solutions Challenge Advocates for Women’s Health, Inc. Advocates for Women's Health exists to provide access to high quality prenatal care and gynecology care to lower-income communities in and around Fresno, CA. They operate a nonprofit OB/GYN clinic located in Fresno. American Rescue Workers (ARW) ARW is a faith-based, non-profit organization providing homelessness and hunger prevention services in Central PA since 1934. ARW cares holistically for men, women, and children who find themselves facing food insecurity, and emergency situations that may lead to homelessness, or an actual homeless crisis, by providing shelter and social services. ARW serves people no matter their faith, regardless of faith. Asian Americans Advancing Justice Southern California (AJSOCAL) AJSOCAL is a social justice organization that protects and strengthens the rights and dignity of AAPI communities, especially those that are most disadvantaged. Byrd Cancer Education and Advocacy (BCEA) BCEA’s mission is to effectively assist individuals battling cancer by connecting them to vital support and resources. BCEA ensures that all relevant information reaches those in need, guiding them towards the resources necessary to fight their battle against cancer. Catholic Charities of the Diocese of Santa Rosa Catholic Charities of the Diocese of Santa Rosa creates access to opportunities for self-sufficiency by providing innovative and compassionate services to people of all backgrounds, beliefs and cultures. Chosen Hearts Chosen Hearts’ mission is to rebuild lives and restore hope by fostering a sense of community and creating lasting, positive change. Columbia Student Medical Outreach The Columbia Student Medical Outreach Program (CoSMO) Clinic is the oldest and largest student-run free clinic at the Vagelos College of Physicians and Surgeons at Columbia University. At its core, CoSMO is guided by the belief that all people—regardless of immigration or insurance status—deserve access to high-quality, equitable medical care. Eagle’s Nest Community Kitchen and Resource Center and Mobile Pantry Eagle’s Nest Community Kitchen, Resource Center and Mobile Pantry’s mission is to empower underserved and rural communities through hands-on STEM education grounded in sustainable agriculture. By combining mobile workshops, community gardens, and mentorship, they deliver accessible training in science, technology, engineering, and math that builds practical skills, advances food security, and fosters environmental stewardship. Through collaborative partnerships and by honoring local knowledge, they cultivate resilient communities and inspire the next generation of agricultural innovators. eClose Institute eClose Institute’s mission is to make medically relevant scientific discoveries using an education platform that embraces equality and empowers participants to contribute ideas, life experience and experimental data to improve disease treatment. Equal Hope Equal Hope is an organization dedicated to saving lives and improving quality of life by eliminating health inequities. This organization challenges the status quo in striving to understand the context of people’s lives and the barriers they experience to help them achieve better health outcomes for their lives. Through research, quality assessment and improvements, advocacy, education, and patient navigation, they approach health holistically to achieve sustainable outcomes and true health equity. Food For Free Committee Food For Free improves access to healthy food through establishing innovative programming and partnerships to overcome barriers and strengthen the community food system. They believe that access to healthy food is a fundamental right. Grassroots Gardens of Western New York (GGRWNY) The missions of GGRWNY is to share knowledge, powers, and resources to grow health food, heal systemic harm, and strengthen neighborhood connections through community gardens. Greater Providence YMCA (GPYMCA) GPYMCA builds healthy spirit, mind, and body for all, through inclusive programs and relationships grounded in core values of caring, honesty, respect, and responsibility. Programs are intentionally designed to close equity gaps in health, education, and wellness. GPYMCA serves individuals and families across all life stages and income levels, including medically vulnerable and underserved populations. Hearts of Valor INC Hearts of Valor’s missions it to keep the heart pumping through advocacy, collaboration, education, and support. Ibn Sina Foundation Ibn Sina Foundation ensures the health of the community by providing integrated, preventive, and primary care in a clinical setting through the dissemination and application of health-related knowledge, thereby enhancing the quality of life for future generations. India Home India Home is a non-profit organization dedicated to addressing the needs of and empowering the South Asian and Indo-Caribbean senior immigrant community in New York City through culturally competent services. At India Home’s centers, seniors find community and resources through a diverse range of programs and activities. Programs include congregate meals, creative aging programs, case management programs, and educational talks on health, nutrition, financial safeguards and elder law. La Colaborativa La Colaborativa empowers the Latinx community, enhancing social and economic health, and holding institutional decision-makers accountable. Lancaster County Food Hub At the heart of the Lancaster County Food Hub’s (LCFH) work is a strong commitment to meeting basic human needs, fostering respectful relationships, and connecting neighbors with supportive services in a nurturing and welcoming environment. Guided by their vision of a Lancaster County where every individual is supported and empowered to live with dignity and stability, they strive to not only provide immediate relief but also to create pathways to lasting self-sufficiency. Maryland Foundation of Dentistry (MFD) MFD is dedicated to improving oral health outcomes and preserving dental function for one of the state’s most vulnerable populations: adults with intellectual, physical, and/or developmental disabilities who are unable to afford the cost of dental care. Maternity Care Coalition (MCC) The missions of MCC is to improve the health and well-being of pregnant women and parenting families and enhance school readiness for children 0-3. MCC achieves this through direct service, advocacy, and research, in collaboration with individuals, families, providers, and communities. Medical Motor Service of Rochester and Monroe County, Inc. Medical Motor Service of Rochester and Monroe County’s mission is to provide specialized transportation for community organizations, as well as individuals with disabilities and special needs to improve their independence and quality of life. Milwaukee Consortium for Hmong Health (MCHH) MCHH’s mission is to create a thriving and healthy Southeast Asian and Hispanic community by empowering families through education and screenings. MCHH utilizes established community health workers and focuses on addressing health disparities related to cancer and chronic disease among the Hmong, Bumese, Karen, Karenni, Lao, and Hispanic populations living in Milwaukee, WI and other areas if needed. Mission Hospice and Home Care Mission Hospice and Home Care is delivering compassionate support and exceptional care in the home for individuals and communities, guiding them with choice and dignity to navigate significant care decisions. North Alabama AHEC (NAAHEC) The mission of the NAAHEC is to improve healthcare access, quality, and equity in rural and underserved communities across North Alabama. They strengthen the health workforce - particularly through the development of community health workers by providing comprehensive training, resources, and advocacy. By fostering strong community partnerships and promoting healthcare literacy, NAAHEC aims to address disparities, improve outcomes, and cultivate a healthier future for North Alabama. Our Neighbors’ Table Hunger comes in many forms. Our Neighbors’ Table is committed to establishing a community that provides for the whole person with nourishing food, kindness and dignity. Panhandle Breast Health Panhandle Breast Health works to decrease breast cancer deaths by providing education and reducing financial barriers to increase screening rates. Pitney Meadows Community Farm Founded in 2026, Pitney Meadows Community Farm’s mission is to celebrate and explore agricultural education, healthy food production, and recreation. Located on 166 acres in the heart of the city of Saratoga Springs and preserved in perpetuity as a working farm, Pitney Meadows is a unique resource. Prince William County Community Foundation (PWCCF) PWCCF’s mission is to create a stronger, healthier, and more connected community by addressing critical needs in food insecurity, health & wellness, scholarship, and philanthropy. PWCCF is committed to empowering individuals and families through equitable access to nutritious food, comprehensive healthcare, educational opportunities, and community-driven support. By fostering partnerships and promoting sustainable solutions, PWCCF aims to enhance the quality of life for all, ensuring a brighter future for every member of their community. Raytown Christian Church (Raytown Summer Lunch Ministry) Raytown Summer Lunch Ministry’s mission is to provide nutritious and kid-friendly meals to children during the summer months when they are not in school and receiving school meals. Regents of the University of California, Davis UC Davis Health is improving lives and transforming health care by providing excellent patient care, conducting groundbreaking research, fostering innovative, interprofessional education, and creating dynamic, productive partnerships with the community. RSVP Volunteers RSVP Volunteers creates and runs unique community programs powered by skilled volunteers to advance education and wellness for all ages and strengthen nonprofits through capacity-building and volunteer services. Second Harvest Food Bank of Orange County Second Harvest Food Bank of Orange County, in collaboration with partners, provides dignified, equitable and consistent access to nutritious food, creating a foundation for community health. The Icla da Silva Foundation The mission of the Icla da Silva Foundation is to save the lives of patients whose only cure is a bone marrow transplant by providing financial, emotional, and logistical support to remove barriers to treatment. There With Care of the Bay Area Founded in 2012, the mission of There With Care of the Bay Area is to provide a wide range of meaningful and fundamental services to children and families during the critical phase of a medical crisis. Universal Community Health Center Universal Community Health Center’s mission is to provide quality and accessible healthcare to under-served communities and to provide a patient centered model of care to empower communities towards wellness. West Cancer Foundation West Cancer Foundation breaks through barriers to cancer care and improves patient outcomes by providing accessible patient resources, early detection and education, and community-based research. Westside Family Healthcare Westside Family Healthcare’s mission is to improve the health of communities by providing equal access to quality healthcare, regardless of ability to pay. National Strategic Collaborations Foundation of Asthma and Allergy Impact Rescue (AAIR) The mission of The Foundation for Asthma and Allergy Impact and Rescue (AAIR) is to make sure that every child is rescued at school, healthy at home, and connected to care. Family Reach Foundation Family Reach is a nonprofit that provides non-medical financial support to families facing cancer. Cancer treatment requires more than medicine — families need a roof over their heads and food on their tables to survive. If a family can’t meet these basic needs, cancer treatment takes a back seat. They work with patients, providers, and community organizations to challenge the systems that force families to choose between their health and their home. LUNGevity Foundation LUNGevity Foundation is transforming what it means to be diagnosed and live with lung cancer through research, advocacy, and community. This mission brings them closer to their vision: a world where no one dies of lung cancer. Association of Black Cardiologists The Association of Black Cardiologists is dedicated to preventing and treating cardiovascular disease, including stroke, through education, research, advocacy, and community engagement, striving for optimal health for all by eliminating disparities. Cholangiocarcinoma Foundation (CCF) The Cholangiocarcinoma Foundation’s (CCF) mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma (bile duct cancer). Founded in 2006, in Salt Lake City, UT, by a family who lost a loved one to cholangiocarcinoma, CCF has grown to become the leading global resource in research, education, and public awareness. ZERO Prostate Cancer Zero Prostate Cancer’s mission is to improve and save lives from prostate cancer through advocacy, awareness, education, and support. GO2 for Lung Cancer GO2 for Lung Cancer relentlessly confronts lung cancer on every front, every day, for everyone. As the nation’s leading lung cancer advocacy organization that was founded by patients and survivors, they are dedicated to increasing survival and quality of life for those at risk, diagnosed, and living with lung cancer. National Minority Quality Forum The National Minority Quality Forum (NMQF) is a national 501(c)(3) with a mission to reduce patient risk for all. Young Survival Coalition (Breast) Young Survival Coalition supports the young breast cancer community and ignites global collaboration to improve quality of life worldwide. Black Women’s Health Imperative Black Women’s Health Imperative’s mission is to solve the most critical health issues that Black women and girls face through innovative programs, transformative research, and lifesaving policies.
What Happens When You Take Magnesium and Vitamin D Together?
Magnesium and vitamin D help with bone health, mental health, and cardiovascular health. It's usually safe to take magnesium and vitamin D together.
TAVR valve for AR , a recent Edwards acquisition, delivers long-term value
The J-Valve System is associated with positive 10-year outcomes for patients with severe AR, according to new research out of China. It also performs well in patients with severe AS.
Cardiologist impressed by experimental pill that significantly lowers cholesterol
An experimental oral PCSK9 inhibitor is associated with LDL-C reductions that could prove to be a game-changer for patient care.
Scientists found a hidden fat switch and turned it off
Researchers have discovered a previously unknown enzyme that plays a crucial role in fat production. By blocking it, they stopped weight gain, reduced liver damage, and lowered harmful cholesterol levels in animal studies. The finding opens the door to a new kind of medication that could tackle obesity, fatty liver disease, and cardiovascular disease all at once.
FDA announces recall of Johnson & Johnson devices after multiple injuries, 1 death
The devices are being recalled due to a higher-than-expected failure to detach rate. Customers should not use them going forward.
New recall includes nearly 23K bottles of triglycerides drug used to treat heart disease
New Jersey-based Zydus Pharmaceuticals has recalled nearly 23,000 bottles of its icosapent ethyl capsules due to leakage issues that may have weakened their effectiveness.