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Packers’ New Addition Named Top Week 1 Fantasy Sleeper
Week 1 can be a time when players surprise you with unexpected roles. It is a good chance for fantasy football players with an appetite for risk to find success. One name that is a risky fantasy proposition with potential high-end outcomes is Green Bay Packers running back Kaleb Johnson. The former third-round pick was […] The post Packers’ New Addition Named Top Week 1 Fantasy Sleeper appeared first on HEAVY.
Residential air pollution linked to higher depression scores among 9/11 responders: Study
9/11 first responders' exposure to air pollution and extreme heat in the neighborhoods they live in compounded poor health outcomes, a new study finds.
James McAvoy reacts to Christopher Abbott’s casting as Professor Xavier in new ‘X-Men’ film (exclusive)
From one Xavier to another! James McAvoy is reacting to Christopher Abbott’s casting as Professor Charles Xavier in Marvel’s upcoming ‘X-Men’ film.
A resource to help hospitals build the business case for diagnostic stewardship
The Society for Healthcare Epidemiology of America (SHEA) has published a new resource describing how diagnostic stewardship can improve patient outcomes, strengthen hospital quality metrics and reduce ...
3 burning Blackhawks questions entering 2026-27 NHL season
The Chicago Blackhawks once again missed the Stanley Cup Playoffs in 2026. The Blackhawks did not reach the highs that similar teams such as the San Jose Sharks reached a year ago. But Connor Bedard and his teammates still made progress as a team in 2025-26. The Blackhawks want to turn the corner sooner rather than later. Chicago has some very […] The post 3 burning Blackhawks questions entering 2026-27 NHL season appeared first on ClutchPoints.
Yankees news: Aaron Boone gives Anthony Volpe his flowers
NEW YORK– It may have been fair to assume that 24-year-old infielder Anthony Volpe had already received his final chance to impact the 2026 New York Yankees when he last played on August 1st against the Chicago Cubs. But as the former first-round pick rounded the bases after mashing a seventh-inning grand slam in New York’s 10-3 win over the […] The post Yankees news: Aaron Boone gives Anthony Volpe his flowers appeared first on ClutchPoints.
AHA Releases Disability Health Resources and Announces Listening Sessions
The American Hospital Association (AHA) recently released a resource hub and issue brief to help hospitals and health systems strengthen disability competence, improve accessibility and advance health outcomes for people with disabilities.
Man Utd outclass Sabah on Champions League return
Manchester United cruised to a 4-0 win on their return to the Champions League for the first time in three seasons as Azerbaijani champions Sabah were taught a lesson on their debut among Europe's elite on Thursday.For coach Valdas Dambrauskas it was a return to Old Trafford after his fairytale rise to the Champions League began with a role at Manchester United Soccer Schools, while working several part-time jobs just to make ends meet.
The First Denisovan Arm Bone Offers a New Clue to What These Ancient and Mysterious Humans Looked Like
New fossils, tools and butchered bones put an elusive human lineage into everyday life.
Israeli legislative election and Netanyahu's politics of enmity
Rather than labeling his domestic rivals as outright traitors, Netanyahu frames them as the vehicles that will deliver the enemy's desired outcome. This deliberately blurs the line between legitimate political dissent and national betrayal | Anadolu
Experts Unanimously Predict Panthers-Bears Week 1 Matchup
Multiple NFL experts have predicted the outcome of the Carolina Panthers and Chicago Bears Week 1 game.
What Health Equity Champions Can Learn from Pharmaceutical Sales
The same mechanics can now help people meet new Medicaid work requirements or exemptions, increase referrals to evidence-based health interventions, and dramatically increase enrollment in vital programs that improve health outcomes and reduce inequities.
Anomaly Insights, Inova Health partner on AI-powered RCM
Artificial intelligence-powered payer intelligence startup Anomaly Insights announced Thursday a collaboration with Inova Health to improve payment outcomes and support revenue management operation | Through the partnership, Anomaly will provide Inova with additional data and analytics to evaluate payer behavior and payment outcomes.
Q&A: 12 News political analyst breaks down RI primary results
12 News political analyst Joe Fleming was in studio to discuss the outcomes and major takeaways of the Rhode Island Democratic primaries.
Panthers vs Bears: Matchups to watch
We look at two key match-ups on the field and one bonus match-up that could decide the outcome of Panthers vs Bears.
Bunkerhill Health Names Dr. Azita Hamedani as First Chief Clinical Officer
SAN FRANCISCO, September 10, 2026--Bunkerhill Health, whose long-horizon AI agent helps health systems translate their goals into outcomes, today announced the appointment of Azita G. Hamedani, MD, MPH, MBA, as its first Chief Clinical Officer.
Zverev eases into US Open semi-finals and breaks Becker record
Alexander Zverev on Wednesday eased into the US Open semi-finals with a 6-2, 7-5, 6-1 victory over Dutchman Botic van de Zandschulp. The French Open champion recorded his 23rd Grand Slam victory of the season, surpassing Boris Becker's previous German record of 22.
Dodgers news: Shohei Ohtani hits IL with 16 games left amid injury concerns
The Dodgers have officially placed Shohei Ohtani on the 15-day injured list, manager Dave Roberts confirmed after Wednesday’s 14-1 win over the Reds , ending weeks of speculation over how long the two-time reigning MVP could keep playing through pain . Roberts said the decision came after conversations with Ohtani, doctors and the training staff, […] The post Dodgers news: Shohei Ohtani hits IL with 16 games left amid injury concerns appeared first on ClutchPoints.
Seahawks news: Drew Lock speaks up on unexpected night amid Sam Darnold injury
The Seattle Seahawks raised their Super Bowl LX banner on Wednesday night. Then, they took on the New England Patriots in a rematch of the big game. Quarterback Sam Darnold exited with an injury in this game. But backup Drew Lock was ready to answer the challenge. Lock entered the game in the first quarter, and he went to work. He finished the game […] The post Seahawks news: Drew Lock speaks up on unexpected night amid Sam Darnold injury appeared first on ClutchPoints.
Patriots news: Mike Vrabel sums up doomed Drake Maye-led drive vs. Seahawks
The New England Patriots had a chance to avenge their Super Bowl loss in Week 1 against the Seattle Seahawks. They were driving down the field while trailing by three. With seconds remaining in the game, Drake Maye attempted to throw a touchdown. That is when disaster struck. Maye’s pass was intercepted by Josh Jobe in the end zone. The Seahawks […] The post Patriots news: Mike Vrabel sums up doomed Drake Maye-led drive vs. Seahawks appeared first on ClutchPoints.
US Open news: Carlos Alcaraz shares true feelings after wild Ben Shelton upset
Carlos Alcaraz, outlasted by Ben Shelton in the five sets of the US Open quarterfinals, had nothing but grace to show after a thrilling night. The Spaniard shared his true feelings on social media following the defeat. “What a battle Ben! ❤️ You deserve the win, I wish you the best for the rest of the tournament! 🙌🏻 I leave here happy with my level […] The post US Open news: Carlos Alcaraz shares true feelings after wild Ben Shelton upset appeared first on ClutchPoints.
Saints news: Tyler Shough notches 'biggest accomplishment' before 2nd year
The New Orleans Saints have a lot of reason for optimism coming into the 2026 season, and a lot of that has to do with second-year quarterback Tyler Shough . Shough didn’t begin his rookie season as the QB1 in New Orleans, but he took over for Spencer Rattler midseason and gave Saints fans hope that he might be the quarterback of the future. Now, […] The post Saints news: Tyler Shough notches 'biggest accomplishment' before 2nd year appeared first on ClutchPoints.
Clutch hits remain buried treasure for White Sox
Chicago wastes two bases-loaded opportunities in a 4-2 loss and drops the series to the Pirates
Browns news: Denzel Ward sounds off becoming partial Guardians owner
The Cleveland Browns are preparing for their first game of the 2026 NFL season. Denzel Ward and his teammates are hoping to prove a lot of the team’s doubters wrong on the field. Off the field, Ward has further cemented himself within the city’s sports scene . Ward joined the ownership group of MLB’s Cleveland Guardians, the Guardians announced on […] The post Browns news: Denzel Ward sounds off becoming partial Guardians owner appeared first on ClutchPoints.
Flying Car With (Tiny) NH Angle Gets the OK in Europe: Business NH Magazine
PAL-V, the Dutch firm that has been working for decades on a flying car held aloft by a helicopter-like rotor, has gotten a production license from the European aviation safety agency.
LSU football news: Expulsion is no longer an agenda item at SEC's Thursday meeting
SEC presidents and chancellors will skip LSU football’s expulsion when they meet Thursday. This move cools a heated dispute that had threatened the Tigers’ place in the conference . Yahoo Sports’ Ross Dellenger posted on X, formerly Twitter, on Wednesday that sources told him expulsion is off Thursday’s agenda. “This news comes on the heels of LSU […] The post LSU football news: Expulsion is no longer an agenda item at SEC's Thursday meeting appeared first on ClutchPoints.
Seahawks news: Seattle adds a safety with Nick Emmanwori questionable
The Seattle Seahawks aren’t taking any chances with their safety depth hours before kicking off the 2026 NFL season. With Nick Emmanwori officially questionable for Wednesday night’s Super Bowl rematch against the New England Patriots , Seattle signed safety A.J. Finley from the practice squad to the active roster and elevated Rodney Thomas II, […] The post Seahawks news: Seattle adds a safety with Nick Emmanwori questionable appeared first on ClutchPoints.
🤝 Van Persie heritage continues in the Champions League
Despite Feyenoord's struggles in Barcelona this evening, one special moment added a shine to the event. The Dutch side trailed the LaLiga giants 3-0 heading into the final stages at the Camp Nou on a ...
September 2026 Apple Event Spoiler-Free Video Stream
Apple's "Surprise and Shine" media event kicks off at 10:00 am Pacific Time today with members of the media in attendance. We know that some MacRumors readers who can't follow the event as it's being broadcast are interested in avoiding all of the announcements and waiting until the event video is available for on-demand viewing so as to experience it without already knowing the outcome.
Carrick on Shaw, 'magical' Champions League and Sabah
Manchester United boss Michael Carrick has been speaking to the media before Thursday's Champions League fixture against Sabah at Old Trafford (kick-off 20:00 BST). Defender Luke Shaw has been given an extra recovery day and they will know by Thursday whether he will be in the squad. Dutch defender Matthijs de Ligt has trained well and is "on good track" to make a return soon but United have to "get the balance right" for the next steps.
Fantasy Football Week 1 2026 Start ‘Em Sit ‘Em: Kickers
Kickers get overlooked until the week they cost you a fantasy matchup, and Week 1 is loaded with sneaky traps hiding behind familiar names. A star kicker returning from injury or stuck behind a stalled red-zone offense can quietly bleed points, while a lesser-known leg in a high-powered attack racks up attempts nobody drafted for. Get these calls […] The post Fantasy Football Week 1 2026 Start ‘Em Sit ‘Em: Kickers appeared first on ClutchPoints.
Fantasy Football Week 1 2026 Start ‘Em Sit ‘Em: Quarterback
Week 1 is finally here, and with it comes the annual gut-check every fantasy manager dreads: trusting your gut on a quarterback you drafted or trusting the matchup staring you in the face right now. The names that dominated August mock drafts don’t always match up with the defenses they’re about to face, and a handful of under-the-radar arms are […] The post Fantasy Football Week 1 2026 Start ‘Em Sit ‘Em: Quarterback appeared first on ClutchPoints.
Cristiano Ronaldo snubbed on 2026 Ballon d'Or finalist list
Cristiano Ronaldo’s unfortunate streak of Ballon d’Or nominations seems to continue. The ghost of a failed Ballon d’Or finalist list has again come at this time of year to haunt Ronaldo for the fourth time in a row. A winner of five Ballon d’Or awards, he has been missing from the list for the last four years and has again failed to make it this […] The post Cristiano Ronaldo snubbed on 2026 Ballon d'Or finalist list appeared first on ClutchPoints.
Military Toxic Exposures Appear to Affect Both Mental and Physical Health in Veterans
Environmental hazards encountered during military service, such as Agent Orange and toxins from open-air burn pits, are known to be linked to adverse physical health outcomes. The VA recognizes them as presumptively service related under the Agent Orange Act of 1991 and the Promise to Address Comprehensive Toxics Act of 2022.
Dutch staffing industry rates outpace wider business services
Overall revenue in the temporary staffing sector climbed 5.8% compared with the same period last year.
Dutch scientists pipe office urine into bacteria-filled cells that generate electricity and recover nitrogen and phosphorus, while a related system can produce hydrogen
Pee breaks are one of the most relaxing times in the office when you finally get to have some sane moments to yourself. Which is why most employees take numerous such breaks within a day.
Analysis | How Canada, with elbows up, could hurt Trump in the midterms
The president's fight with our neighbor to the north — a constant over the course of his second term with a focus on trade — has turned ugly in recent weeks.
How Meta’s Billions for Teen Mental Health Can Make a Real Difference
Instead of repeating the mistakes they made with tobacco money, states should set clear goals — and measure outcomes through dashboards accessible to all — for programs addressing social media’s harms to teenagers.
Lions’ Aidan Hutchinson Makes Waves With Comment on Dan Campbell
Detroit Lions edge rusher Aidan Hutchinson said he supports head coach Dan Campbell taking a more serious approach with the team. The post Lions’ Aidan Hutchinson Makes Waves With Comment on Dan Campbell appeared first on HEAVY.
MAC Asks NCAA, CFP to Overturn Western Michigan-Michigan Game Result
The conference previously seemed to accept the game’s outcome.
Why Brandon Marsh's slump will derail Phillies' NL East chances
The Philadelphia Phillies are looking to surpass the Atlanta Braves in the National League East standings. They will need players to step up over the next few weeks amid their pursuit of winning the division. Of course, Philadelphia is hoping its stars can lead the way. Starting pitching is a strength for this Phillies ball club. Zack Wheeler has […] The post Why Brandon Marsh's slump will derail Phillies' NL East chances appeared first on ClutchPoints.
2026's elections could test how skyrocketing trading on prediction markets affects races and results
Officials' fears revolve around the fear that pervasive financial incentives will further damage confidence in elections and democracy if Americans think they're influencing the outcome.
Browns news: Deshaun Watson a team captain for Week 1
The Cleveland Browns and head coach Todd Monken have opted to deploy captains on a week-to-week basis this year, rather than instill season-long captains. The team is young and still trying to figure things out, and Monken believes there are more leaders on the team than just five. Monken will name two offensive, two defensive, and one special […] The post Browns news: Deshaun Watson a team captain for Week 1 appeared first on ClutchPoints.
North Carolina MCO Alliance Health Taps Cortica to Rein in Autism Spending, Improve Outcomes
Ready to dive into what's shaping autism therapy-payer relations? Be a part of the Autism Investor Summit East this November 9–10. Get your tickets here.
Celo to Participate in Merkle Science Meet in Washington, D.C. on September 8th
Celo will participate in Merkle Science Meet in Washington, D.C. on September 8th at 18:00 UTC. Markus will join a panel on the GENIUS Act and the future of U.S. stablecoin regulation.Refer to the official tweet by CELO:Kicking off @thestablecon week today, @MarkusMento speaks at @MerkleScience Mee…
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Florida State's Mike Norvell getting booed is nasty business
Things aren’t going well right now for Florida State football head coach Mike Norvell . Not only did his team lose a game on Monday to SMU, but Norvell is also getting booed by fans . “They just played a video of Mike Norvell announcing that the Marching Chiefs would be in the Macy’s Thanksgiving parade. The crowd booed Norvell. (It did cheer for […] The post Florida State's Mike Norvell getting booed is nasty business appeared first on ClutchPoints.
Florida State's Mike Norvell getting booed is nasty business
Things aren’t going well right now for Florida State football head coach Mike Norvell . Not only did his team lose a game on Monday to SMU, but Norvell is also getting booed by fans . “They just played a video of Mike Norvell announcing that the Marching Chiefs would be in the Macy’s Thanksgiving parade. The crowd booed Norvell. (It did cheer for […] The post Florida State's Mike Norvell getting booed is nasty business appeared first on ClutchPoints.
Scientists Are Still Trying To Understand How the Moon Formed
The Earth and the Moon have nearly identical isotopic compositions, and the Giant Impact Hypothesis strives to explain this. New research into the ancient impact shows how the temperature of both worlds, and how it affects the strength of the materials involved in the collision, shaped the outcome, including the isotopic compositions.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Fantasy Football D/ST Rankings: Week 1 2026
There is plenty of fantasy football speculation running backs . And there are some undervalued tight ends . But people often forget about the defenses. Don’t do it! Pick a good one and stick with it. And here are the fantasy football defense and special teams rankings for Week 1 of the 2026 NFL season. The Week 1 list looks a lot like the usual […] The post Fantasy Football D/ST Rankings: Week 1 2026 appeared first on ClutchPoints.
If the Saints win/lose vs. Lions
What either outcome means for the black and gold in Week 1.
Your personality may be more genetic than scientists realized
More than 1,200 genetic variants have been linked to the Big Five personality traits, and many of the same variants are also associated with health, longevity, careers, income, and everyday habits. The findings reveal a surprisingly wide genetic connection between personality and life outcomes while showing that environment still plays a powerful role.
Accenture and Google Cloud Deepen Partnership with Formation of New Accenture Gemini Enterprise Business Group
Accenture and Google Cloud today launched the Accenture Gemini Enterprise Business Group, a global group designed to help clients scale Gemini Enterprise outcomes in the agentic AI era.
Polish students outperform EU average in math, reading and science as global scores slide
Polish students outperform the EU average in educational outcomes but remain below pre-pandemic levels.
NFL Power Rankings: Week 1
The hardest part about doing NFL power rankings for Week 1 is that no one really has any freaking clue where these teams should be. We’re just projecting based on last season’s performance and the changes made over the offseason, but reality will be a completely new outcome. I decided to give the Super Bowl […]
Lecxe Consulting Debuts to Help Indian Businesses Turn AI into Business Outcomes
Lecxe Consulting is an AI consulting and implementation company helping Indian businesses build custom AI powered business systems. Since inception, Lecxe has helped clients reduce costs up to 80% every month through AI-powered business systems, while simplifying the way organisations operate.
Patriots' Christian Gonzalez sends immediate reaction to massive contract extension
It is finally over. The New England Patriots and Christian Gonzalez waited until less than two days before opening kickoff to get a deal done, but they have agreed to a record-breaking, four-year, $135 million contract extension. Fans can take a deep breath , and so can the highest-paid cornerback in NFL history. “Thank you Lord!” he posted on […] The post Patriots' Christian Gonzalez sends immediate reaction to massive contract extension appeared first on ClutchPoints.
Sununu, Pappas both face tests in quest for New Hampshire US Senate seat
NH Senate primary will see contested races on both sides, the outcomes of which could affect their party’s chances in the November general election.
Contract grade for Christian Gonzalez's $135 million extension with Patriots
It’s about time . One of the many stories around the New England Patriots this offseason was their contract negotiations with star cornerback Christian Gonzalez. Gonzalez firmly entrenched himself as one of the best cornerbacks in the league last season. With the 2026 season being his fourth season in the league, Gonzalez was due for a contract […] The post Contract grade for Christian Gonzalez's $135 million extension with Patriots appeared first on ClutchPoints.
What to know about Canada's escalating trade war with the U.S.
Canada struck back at U.S. President Donald Trump on Tuesday with tariffs on about $20 billion worth of U.S. goods. The outcome could resonate far beyond Canada.
What to know about Canada's escalating trade war with the U.S.
Canada struck back at U.S. President Donald Trump on Tuesday with tariffs on about $20 billion worth of U.S. goods. The outcome could resonate far beyond Canada.
Browns news: KC Concepcion makes confident admission about Deshaun Watson
KC Concepcion is soon going to experience real NFL action for the first time, with the Cleveland Browns scheduled to face the Jacksonville Jaguars on Sunday at EverBank Stadium in Jacksonville. Concepcion is a name to watch on the Browns side , as the rookie carries some intrigue. For one, he’s yet to play a regular-season game in the NFL. But how […] The post Browns news: KC Concepcion makes confident admission about Deshaun Watson appeared first on ClutchPoints.
Steelers news: Mike McCarthy's intriguing captains decision for 2026 season
The Pittsburgh Steelers are currently gearing up to kick off the upcoming 2026 NFL season. The Steelers this year will see the reunion of head coach Mike McCarthy and quarterback Aaron Rodgers, who won a Super Bowl together well over a decade ago with the Green Bay Packers. Now, McCarthy has made an interesting decision regarding the Steelers’ team […] The post Steelers news: Mike McCarthy's intriguing captains decision for 2026 season appeared first on ClutchPoints.
Brewers Thrilling Comeback Win vs. Cubs Clinches Season Series
Jackson Chourio’s clutch hitting and Luis Lara’s defensive heroics fueled a Milwaukee Brewers late-inning rally over the Chicago Cubs.
Labor unions are growing, but where depends on state politics
A new study shows U.S. union membership grew by over 411,000 workers last year, with collective bargaining states driving three times the growth of right-to-work states.
Andy ‘the Butcher’ Williams, Every Time I Die guitarist and pro wrestler, dies at 48
Williams reportedly collapsed ringside after a tag team match on Sept. 5.
'Rovers will be wondering how they got beat'
Former Blackburn Rovers striker Kevin Gallagher thinks Rovers fans will be pleased with their showing in the Lancashire derby against Preston on Saturday, but small margins decided an unwanted outcome.
Language Access: A Strategic Performance Driver for Providers
Learn how a total cost of ownership approach to language access can improve efficiency, patient outcomes, compliance and financial performance.
LYMA Launches P.O.W.E.R. Index for Wellness Science
LYMA's P.O.W.E.R. Index tackles wellness science-washing with five tests for evidence, outcomes and value. Explore the new framework.
Inside the business of finding expert witnesses for major trials
In high-stakes trials, the outcome can hinge on who takes the stand as an expert witness — and one of the most experienced companies in finding and supplying...
US Open news: Jessica Pegula calls out influencers
Jessica Pegula has spoken up about the rise of influencers at the US Open . She says there should be a clear line between promoting tennis and disrupting the matches . The world No. 3 talked with Front Office Sports about the bigger role influencers and content creators now play at the tournament. Pegula said they can help the sport. However, she […] The post US Open news: Jessica Pegula calls out influencers appeared first on ClutchPoints.
Virginia Tech news: James Franklin blasts 'un-American' flag thrown
The James Franklin era at Virginia Tech has begun. Franklin got to enjoy the Enter Sandman entrance for the Hokies for the first time as the head coach. His team was also dominant, winning 73-3 over VMI. In the third quarter, Marcellous Hawkins Jr. scored on a two-yard run, putting the Hokies up 58-0. Hawkins then went up to one of the members of […] The post Virginia Tech news: James Franklin blasts 'un-American' flag thrown appeared first on ClutchPoints.
Orioles news: Of course Luis Robert Jr. is already injured
The Baltimore Orioles are attempting to make a run at the playoffs. As part of that, the Orioles signed Luis Robert Jr. , claiming him off waivers from the New York Mets. Now, Robert is expected to miss some time with a hamstring injury , per Bob Nightingale of USA Today. “The Baltimore Orioles, who just took a $5 million gamble picking up CF Luis […] The post Orioles news: Of course Luis Robert Jr. is already injured appeared first on ClutchPoints.
Far right wins big in eastern German state election
Chancellor Friedrich Merz's conservative CDU suffers drubbing, but final outcome too close to call
Tobias Harris Draws Bold Prediction; Tough Spurs Decisions Coming?
Bleacher Report named Tobias Harris the Spurs’ best offseason addition and predicted he would rank top-five on the team in clutch minutes in 2026-27.
Clemson Continues to Fall
Clemson continues to fall as they suffer a crushing defeat to LSU 51-10 Saturday night. It was the outcome many expected, but it looked much worse than we could’ve imagined. Dabo Swinney’s team looked completely outmatched, especially in the trenches. This was the largest deficit the program has faced in Swinney’s tenure. Lane Kiffin’s team …
German director Wenders clarifies views on film and politics
German director Wim Wenders clarified his views about the relationship between filmmakers and politics on Sunday after he caused an outcry at the Berlin film festival earlier this year. Speaking in Venice, where he is presenting a new film about Swiss architect Peter Zumthor, the "Paris, Texas" director said he had been misunderstood.
German director Wenders clarifies views on film and politics
German director Wim Wenders clarified his views about the relationship between filmmakers and politics on Sunday after he caused an outcry at the Berlin film festival earlier this year.
German director Wenders clarifies views on film and politics
German director Wim Wenders clarified his views about the relationship between filmmakers and politics on Sunday after he caused an outcry at the Berlin film festival earlier this year.
Predicting Notre Dame football’s game-by-game record in 2026
Notre Dame football starts its season today, and here is a game-by-game prediction of each outcome during the 2026 season.
Lukas Jannick moved for love, now he has to navigate high NYC costs
Lukas Jannick, a Dutch native, navigates NYC's high living costs and cultural differences while documenting his life on YouTube.
Time lords prepare to kick leap seconds into the next millennium
Risk of an unprecedented negative adjustment prompts plan to let UTC drift by as much as an hour
Extremely Rare 'Rapunzel Syndrome' Can Cause a Hairball So Large It Requires Surgery
A serious outcome from a compulsive behavior.
Tennessee football news: Faizon Brandon turns heads in Volunteers debut
The Tennessee Volunteers took on the Furman Paladins at Neyland Stadium on Saturday in a clash between the FBS and FCS teams. The Paladins came in 1-0 but were quickly outclassed by the Volunteers and their true freshman quarterback Faizon Brandon, who thrilled the Neyland Stadium crowd with stellar play in his college football debut. The game came […] The post Tennessee football news: Faizon Brandon turns heads in Volunteers debut appeared first on ClutchPoints.
Michael Hutchinson's Next Chapter Keeps Him Close To Home
Trading his pads for a whistle, the former Jets netminder joins the Selkirk Steelers staff to mentor local prospects while launching a new goaltending school in Winnipeg.
Gary Neville predicts the outcome of Arsenal v Chelsea
Gary Neville has predicted how he expects the Chelsea-Arsenal game to end as two unbeaten clubs prepare to meet in the Premier League this weekend.Arsenal secured a hard-fought 1-0 victory against Ast...
ART-conceived children show reassuring long-term health outcomes
The birth of Louise Brown in 1978, the world's first baby conceived through assisted reproductive technology (ART), was a major breakthrough that reshaped the field of reproductive medicine.
Adult Post-operative Mental Health Outcomes Following Abdominal and Orthopedic Surgeries: A Scoping Review
Poor mental health has been shown to negatively impact surgical outcomes; however, the impact of surgery on mental health remains under-investigated. Therefore, in this scoping review, we aimed ...
Manny Rutinel resigns from Colorado legislature to focus on congressional race
The Democrat running for a key congressional race — whose outcome could decide the balance of power in the U.S. House — on Friday resigned from the Colorado legislature. State Rep. Manny Rutinel is turning his attention to his campaign in Colorado’s 8th Congressional District, where he is challenging Republican U.S. Rep. Gabe Evans. The […]
Vote in HME Business Product of the Year Competition
Innovation is the lifeblood of the durable medical equipment industry. It’s not technology for technology’s sake — it’s improving the outcomes, quality of life, inclusion and everyday abilities for patients across the country. Here’s your chance to directly recognize innovations you think are moving the industry — and most importantly, its patients — forward. Voting…
A Single Vikings Reality Points Toward a Promising Outcome
No team can win the Super Bowl in training camp and the preseason. However, there are some teams that lose […]
Plain Language as Scientific Accountability: How to Communicate Science Beyond Academic Audiences
This joint UW/Fred Hutch—Penn CFAR session brings the two CFARs together in conversation around how we communicate science beyond academic audiences. This session will present examples of technical language from HIV cure, prevention, and treatment research and ask what happens when the people most affected by the science cannot easily understand what researchers are saying. […]
Opinion: To truly celebrate Illinois workers, boost employee ownership this Labor Day
Employee stock ownership plans lead to lower turnover, high productivity and greater pride in outcomes, but there are just over 300 in Illinois.
U.S. issues sanctions on Turkish bank that it is 'financial lifeline' for Iran
The actions come nearly a week after Treasury Secretary Scott Bessent announced “Operation Economic Outcast"
U.S. issues sanctions on Turkish bank that it is 'financial lifeline' for Iran
The actions come nearly a week after Treasury Secretary Scott Bessent announced “Operation Economic Outcast"
The Public Health Cost of Eliminating Race and Ethnicity Data
This is bigger than a singular elimination of race and ethnicity questions. It could accelerate the second wave of widespread reductions to demographic data, leaving public health officials with even less information to deliver better health outcomes for all Americans.
The Pants Predicts: Iowa Hawkeyes vs Northern Illinois
The Iowa Hawkeyes are a big favorite over NIU in their season opener. Our staff predicts the outcome vs the spread.