SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " option " 2,052 found 🔀 AI-powered Shuffle
Walmart to test health ambassador program in rural stores
Walmart continues to find ways to build and expand its healthcare business. The efforts, which include store pharmacists, telehealth options for Walmart+ members, now include testing a health ambassador role...
Walmart to test health ambassador program in rural stores
Walmart continues to find ways to build and expand its healthcare business. The efforts, which include store pharmacists, telehealth options for Walmart+ members, now include testing a health ambassador role...
Grayson College program teaches the business of agriculture
Grayson College has launched a new agricultural sciences program designed to prepare students for careers in farming, ranching, and agribusiness, addressing the gap left by retiring producers and offering hands-on learning and dual-credit options.
Karma TMS Marks 20,000 TMS Treatments, Transforming Mental Health Care Across the Coachella Valley and Riverside County
Palm Springs, California--(Newsfile Corp. - September 15, 2026) - Karma TMS PC, a leading provider of Transcranial Magnetic Stimulation (TMS) therapy in Southern California, today announced it has delivered more than 20,000 TMS treatments to patients across the Coachella Valley and Riverside County. The milestone reflects nearly a decade of growth for the practice. It underscores the rising demand for effective, non-invasive, medication-free options for treatment-resistant depression, anxiety,..
Zolli Candy CEO Alina Morse: Business is booming
Zolli Candy founder and CEO Alina Morse joins 'Mornings with FOX Business' to discuss Hershey's expansion into healthier options and the growing market for zero-sugar and dye-free children's sweets.
Autodesk launches Support for Small Business and expands tools to help small teams save time, manage costs, strengthen security, and sell what they make
Autodesk for small business adds dedicated support, new Flex options, security updates, and Fusion commerce integrations for small teams.
Are Options Traders Betting on a Big Move in Inspired Entertainment Stock?
Investors need to pay close attention to INSE stock based on the movements in the options market lately.
North Central District Health Department offering grant for healthier concession stands
A local health department is aiming to bring healthier options to school concession stands.The North Central District Health Department—based in O'Neill—said it
Introducing: Supernova Serena Williams Gets Her Own Audemars Piguet Royal Oak
The new chronograph makes a compelling case for the power of pink.
Sources: Liverpool's plan for Ronald Araujo purchase option revealed
Football Insider exclusive as Liverpool manager Andoni Iraola stares towards owner John Henry, who watches from a circular inset.
NC State Health Plan, Atrium Health partner to expand options for 750,000 members
RALEIGH, N.C. — The North Carolina State Health Plan and Atrium Health have announced a new partnership that will expand coverage options for plan members begin
Dr. Oz helps Georgia’s John King promote health insurance tool for businesses
The tool is aimed at helping businesses provide more health insurance options for their employees.
Everett faces losing AquaSox and jeopardizing stadium project
Everett's $120 million stadium project faces a critical deadline as the AquaSox weigh options to meet MLB compliance issues.
Overture Center expands accessibility options for arts audiences
MADISON, Wis. — The Overture Center is expanding accessibility options to help more people enjoy performances and other arts events at the downtown venue.
Where to watch India vs. Afghanistan free live stream, TV channel, start time for 2nd ODI match
Here's everything you need to know about India vs. Afghanistan, including TV channel and streaming options for the T20 matchup.
Please Stop Conflating Sports Betting Handle With Spending On Entertainment
Editor’s note: The Cashout for paid subscribers will publish on Tuesday. Every September there’s a huge uptick in how much people bet on sports with the start of football season. Which means it’s time to get ahead of a ridiculous narrative before it picks up steam on social media or in mainstream media. Subscribe Every few months I see some version of this: [ Charlie Bilello@charliebilello Americans bet over $165 billion on sports last year, which is more than they spent on movies, books, concerts and sports tickets - combined. 1:00 PM · Jun 28, 2026 · 4.1M Views 258 Replies · 674 Reposts · 4.23K Likes ](https://x.com/charliebilello/status/2071217050328895935?s=20) Fortune published this in July. The headline and start of the story tell the same narrative (emphasis added): Gambling becomes America’s favorite pastime as Americans spend more on sports bets than movies, arts, museums, and music combined: The North American box office totaled $8.87 billion in 2025, which is still 22% below pre-pandemic levels. Recorded music revenue hit a record $11.5 billion. Live music like concerts and festivals brought in $18.51 billion. Meanwhile, book publishers tracked by the Association of American Publishers reported $14.6 billion for the year. And the U.S. museum industry generated an estimated $16.4 billion. Add it up and the total comes to roughly $70 billion, which is less than half what Americans wagered on sports. The story, to its credit, goes on to tell us why sports betting is entirely different, although people who only read headlines will miss that nuance. (The tweet above definitely skips over the nuance.) I will mostly be preaching to the choir here, but it’s worth saying out loud: Wagering money on sports is not the same thing as spending on entertainment from a financial perspective. When you spend money on a movie or concert ticket, that money is gone. You exchanged money for an experience. It’s a good trade! I get to have fun for “x” dollars. (Unless the movie sucks, I guess.) When you bet money on sports, the money is not necessarily gone every time you wager it. It could be gone, but sometimes it’s not and you actually get more money back! That’s not “spending” money or something you should try to compare directly to entertainment spend. A far better comp would be how much people lose at sports betting. That number was more like $17 billion in the US last year, at least for state-regulated sportsbooks. Why are we trying to equate handle and entertainment spending? I dunno. It makes for splashy headlines, I guess. Now, people should be betting for entertainment, and not because they expect to win in the long term; no doubt about it. Anyway, here’s hoping I don’t see people saying Americans “spent” hundreds of millions of dollars on sports betting this fall. Mindway AI and DraftKings Expand Responsible Gaming Drive with Launch of Gamalyze American Football In time for the NFL kickoff, Mindway AI has expanded its partnership with DraftKings to launch Gamalyze American Football the second title in the neuroscience-based Gamalyze Sports collection. Following the success of Gamalyze Football (soccer) during the FIFA World Cup, this gridiron-themed update replaces static questionnaires with immersive, stadium-inspired gameplay. Backed by 10+ years of Aarhus University research, Gamalyze evaluates real-time decision-making to deliver instant, unbiased player risk assessments. Integrated into DraftKings’ platform and nationwide activations, it engages fans when excitement peaks. Ready to upgrade your player protection? Contact Mindway AI to try Gamalyze Sports today. Gambling news roundup 🚨The important stuff 1st NFL Sunday of Season ‘Champagne-Popping Day for Bettors’ (Covers): “The first NFL Sunday of the season was a champagne-popping day for bettors, while the book was left cleaning up the corks,” Caesars’ head of football Joey Feazel said prior to the Sunday night game. “Caesars Sportsbook reported that Detroit’s Jahmyr Gibbs, Baltimore’s Derrick Henry, Indianapolis’ Jonathan Taylor, and Atlanta’s Bijan Robinson were among the top five most-bet players to reach the end zone, and all of them cashed tickets.” [ Ben Fawkes@BFawkes22 A @CaesarsSports oddsmaker on how Week 1 has gone so far: “The first NFL Sunday of the season was a champagne-popping day for bettors, while the book was left cleaning up the corks.” ➡️8 of 10 most popular anytime TD scorers cashed 1:31 AM · Sep 14, 2026 · 276K Views 16 Replies · 16 Reposts · 615 Likes ](https://x.com/BFawkes22/status/2099310001927995849?s=20) 🔍 Are we already getting a “customer-friendly results” narrative in Week 1? NFL Commissioner Roger Goodell spoke with CNBC about the prediction markets industry: “We think that there needs to be stronger regulations into the predictive markets,” Goodell said. “We want to see that to protect the integrity of our game. We want to make sure we’re protecting the consumers that are on those platforms for the NFL. So, we’re continuing to have conversations with them and talk to them about the things that we think they need to do to strengthen that so that they could be potential partners at some point in the future.” More on the NFL + PMs: [ Straight to the Point Quid Pro Quo The NFL has asked Kalshi and other prediction markets to remove certain easy to manipulate markets. Does a potential partnership hang in the balance… Read more 6 hours ago · 19 likes · Steve Ruddock ](https://straighttothepoint.substack.com/p/quid-pro-quo?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1472492) Kalshi was on my podcast?: Kalshi was on my podcast [ The Event Horizon Episode 32: Talking Prediction Market Enforcement With Kalshi’s Robert DeNault Kalshi? On my podcast? Yep… Listen now 5 hours ago · 6 likes · 1 comment · Dustin Gouker ](https://nexteventhorizon.substack.com/p/episode-32-talking-prediction-market-enforcement-kalshi?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1472492) DraftKings Enhances Responsible Engagement Efforts With New Customer Initiatives, Tools and Education (press release): DraftKings Inc. today announced a series of new initiatives designed to promote responsible engagement and increase awareness and use of the tools and resources to help customers make informed decisions and engage responsibly. The efforts include a new digital advertising campaign featuring Kevin Hart and Nick Jonas that promotes responsible engagement, a PGA TOUR sweepstakes that promotes customer engagement with responsible engagement features, the launch of Gamalyze American Football in collaboration with Mindway AI, and new custom cool-off options that give customers enhanced flexibility when choosing a cool-off period. The initiatives build on DraftKings’ commitment to making responsible engagement an integral part of the customer experience and providing players with accessible tools and resources that help them make informed choices about their gaming experience. “At DraftKings, responsible engagement is embedded in how we operate and is essential to building trust with our customers and our long-term sustainability,” said Lori Kalani, Chief Responsible Gaming Officer at DraftKings. “We’ve continued to invest in tools and resources that give customers enhanced access to information about their play and more choices for managing how they engage. From My Budget Builder and My Stat Sheet to player-set limits and new custom cool-offs, we’re continuing to evolve our approach while promoting awareness and use of the tools and resources available to help customers play responsibly.” … DraftKings is launching a new digital advertising campaign featuring Kevin Hart and Nick Jonas that continues the pair’s road trip and promotes responsible engagement and awareness of the tools and resources available to help customers make informed choices about their gaming experience and engage responsibly. The campaign was initially launched on Sep. 10th and will reach customers through digital channels, bringing responsible engagement messaging to fans in an engaging way. bet365 Launches “The Matchup,” a New Weekly Video Podcast Hosted by Super Bowl Champions Chris Harris Jr. and Emmanuel Sanders (press release): "bet365, a global leader in online sports betting and gaming, today announced the launch of “The Matchup,” a new weekly video podcast hosted by former Super Bowl Champions Chris Harris Jr. and Emmanuel Sanders. Featuring current and former NFL players, the original series marks a significant, intentional investment in football as bet365 works to become a go-to destination for U.S. bettors throughout the season. “The Matchup” premieres September 10, with new episodes released weekly in both video and audio formats. Full episodes will be available on YouTube, Apple Podcasts, Spotify and wherever podcasts are available, with clips and additional content rolling out across YouTube, X, Instagram, Facebook, Threads, and TikTok. The show is being produced by Last Row Digital Media. Each week, Harris and Sanders will be joined by guests from across the game to break down the biggest NFL matchups, unpack the latest league news and share perspectives that go beyond the box score. By bringing together two former players with distinct perspectives and firsthand experience, “The Matchup” will give audiences timely context and a deeper understanding of the teams, players and storylines shaping the week ahead. “Every great football conversation starts with a matchup—who has the edge, what everyone is overlooking and what could change the game,” said Chris Harris Jr. “Emmanuel and I have experienced the game from different perspectives, and we want the audience to feel like they are part of the conversation and leave every episode knowing more about the week ahead.” Today’s iGaming companies face new litigation threats as expansive consumer protection statutes spark lawsuits with sky’s-the-limit aspirations, sometimes backed by private funders. Clients of Ifrah Law have a staunch defender in Robert Ward – an agile litigator and case tactician who responds to the changing state of play with creative legal defenses and efficient case-closing strategies. Robert draws on federal clerkship experience and appellate defense work to advise iGaming clients on litigation exposure, white-collar risk, and regulatory defense across multiple jurisdictions. Read More: Robert Ward on Helping iGaming Clients Outmaneuver Lawsuit-Obsessed Adversaries 🔮 Prediction markets Update on legal action in Connecticut: [ Daniel Wallach@WALLACHLEGAL Connecticut says gaming service license holders which received subpoenas over sports prediction markets “are not under investigation” by the @CTDCP but may possess information that could assist the state “in evaluating the conduct of prediction market platforms.” 2:31 PM · Sep 13, 2026 · 844 Views 5 Likes ](https://x.com/WALLACHLEGAL/status/2099143914271670576?s=20) American Gaming Association Opposes CFTC Bid to Block New York Prediction-Market Enforcement (DeFi Rate): “The brief points to the Ninth Circuit’s Aug. 28 decision in KalshiEX LLC v. Assad, which the AGA says supports New York’s authority to regulate sports contracts as gambling. It also cites Kalshi advertising, product comparisons and reporting on Kalshi’s sports volume to argue that the economic product resembles a sportsbook wager more than a conventional financial hedge.” [ Daniel Wallach@WALLACHLEGAL AGA intervenes in CFTC v. NY case to oppose CFTC request for preliminary injunction, says the CFTC’s arguments “obfuscate a simple truth: prediction markets offer sports betting.” Highlights CA9 decision, @DustinGouker (6x), and $1.32 billion in OSB taxes for NY (0 from PMs). Daniel Wallach @WALLACHLEGAL High stakes hearing on Monday in CFTC v. New York State. If SDNY judge Lorna Schofield denies the CFTC’s motion for preliminary injunction, the New York AG would have a clearer path for securing a state court geofencing order against Kalshi, Coinbase, and Gemini Titan. 2:08 AM · Sep 13, 2026 · 4.78K Views 1 Reply · 2 Reposts · 8 Likes ](https://x.com/WALLACHLEGAL/status/2098957043474280584?s=20) Gaming Commission remains member of gambling council after questions raised over ties to Kalshi (Mass Live): “The Massachusetts Gaming Commission will not follow the leads of gaming regulators in Ohio and Michigan and drop ties with the National Council on Problem Gambling over its new association with Kalshi.” Sponsor’s messageTrusted Voices: Conversations About Betting is designed to equip adults, including parents and coaches, with tools and resources to talk to young people about gambling, including information on warning signs, risks and proxy betting. The program is led by retired professional basketball player Randy Livingston and his wife, basketball agent Anita Smith, who share their personal stories related to problem gambling, with the hope of preventing others from experiencing similar harms. Learn more and join the conversation here. 📣 Industry news Gaming M&A: Latest Mergers, Acquisitions and Deals (SBC Americas): “But what else is happening in the world of gaming mergers, acquisitions, investments, and partnerships? Here, we round up some of the news you might have missed.” BetMGM Named Official Sports Betting and Online Casino Partner of the Minnesota Vikings in Canada (press release): BetMGM, a leading iGaming and sports betting operator, announced a multi-year partnership with the Minnesota Vikings, naming it the Official Sports Betting Partner and Online Casino Partner of the team in Canada. The agreement gives BetMGM rights to use Vikings marks across approved sports betting, online casino and marketing activities in Canada. In addition, Vikings Big Kick LuckyTap™, a casino game by Design Works Gaming, is available now exclusively at BetMGM Casino in Alberta and Ontario. “Vikings fans bring a level of passion and loyalty that extends well beyond game day,” said Matt Prevost, Chief Revenue Officer at BetMGM. “As the home of one of the largest collections of sports-themed casino content in North America, BetMGM is uniquely positioned to combine sports fandom with iGaming. We are eager to start football season off strong with another fantastic partnership especially as we expand our reach in Canada to Alberta.” Martin Nance, Minnesota Vikings Chief Marketing Officer, said, “As we continue to deepen our connection with Vikings fans across Canada, we’re proud to welcome BetMGM as the team’s official sports betting and online casino partner in Canada. Their commitment to innovation and fan engagement aligns well with our organization, and we’re excited to create memorable experiences that celebrate Vikings football and connect with Canadian fans in new and meaningful ways.” Caesars Entertainment Launches Ball Rush Jackpots™ in New Jersey,the Latest Proprietary Online Title from Empire Creative™ (press release): Caesars Entertainment, Inc. (NASDAQ: CZR) (“Caesars”) today announced the launch of Ball Rush Jackpots™, a new ball-and-peg style online casino game developed by Empire Creative™, the Company’s in-house game development studio. Now live in New Jersey across Caesars Palace Online Casino, Caesars Sportsbook & Casino and Horseshoe Online Casino, Ball Rush Jackpots is expected to become available in additional jurisdictions where Caesars offers online casino gaming following regulatory approval. The title expands Caesars’ growing portfolio of proprietary online casino titles, following the successful launch of Ca$hline™ earlier this year and further diversifying the Company’s lineup beyond traditional slots and table games. Ball Rush Jackpots follows the traditional ball-drop gameplay experience where players drop a ball down a board filled with pegs to land in a prize slot. As balls navigate independently through a field of pegs, every drop creates new opportunities to collect feature symbols, unlock bonuses and pursue jackpots, delivering a different experience with every round. “Ball Rush Jackpots delivers a different kind of casino experience for our players, combining easy-to-understand gameplay with meaningful customization, exciting bonus opportunities and jackpot potential,” said Matthew Sunderland, Senior Vice President and Chief iGaming Officer at Caesars Digital. “As we continue expanding our proprietary content portfolio, we’re focused on creating games that are simple to pick up, rewarding to revisit and designed around the features players enjoy most.” Bally’s Corporation Secures New Financing to Support the Development of the Bally’s Bronx Project (press release): Bally’s Corporation (NYSE: BALY) (“Bally’s” or the “Company”) announced today that it secured new financing led by WhiteHawk Capital Partners, LP to fund further development of the Bally’s Bronx project and general corporate purposes. The new financing comprises closing date term loan commitments in an aggregate principal amount of $400 million and delayed draw term loan commitments in an aggregate principal amount of $160 million (together, the “Facilities”). … Bally’s Chairman of the Board, Soo Kim, commented, “This important financing allows us to progress the pre-construction planning process so that we are ready to complete the remainder of the capital raise and remain on schedule. Furthermore, the additional liquidity provides us greater flexibility for other capital opportunities.” WORLD JAI ALAI LEAGUE LAUNCHES CENTENNIAL SEASON AND ENTERS NEXT CHAPTER IN MIAMI (press release): The World Jai Alai League will open its 2026 fall season on Tuesday, September 15 at Miami’s JAM Arena, beginning a milestone season that marks 100 years since professional Jai Alai first arrived in Miami. Season X, the tenth season of the Battle Court team-based competition launched in 2022, will also be the first since entrepreneur and sports asset investor Rob Gough acquired the World Jai Alai League in August 2026. The acquisition marks the beginning of a new chapter for the league. World Jai Alai League will maintain the existing Battle Court competition and operating format, with Chief Operating Officer Scott Savin overseeing Season X. Gough and his team will use the coming months to listen to players and fans, evaluate opportunities across the league, and execute plans for a broader evolution of Jai Alai’s presentation, live experience, media, marketing and commercial strategy beginning in 2027. “This is a really unique moment for Jai Alai,” said Rob Gough, Owner of the World Jai Alai League. “We have a sport with more than 100 years of history in Miami, extraordinary athletes and incredible speed, but I also believe there is enormous untapped potential.” bet365 reveals most popular online slots in 3 US states in August (SBC Americas): “In its monthly Gaming Insights and Performance report, growing online casino operator bet365 tracks player trends and game performance in online slots across its North American online casino markets.” The Closing Line is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Implied Volatility Surging for USANA Health Stock Options
Investors need to pay close attention to USNA stock based on the movements in the options market lately.
Apple Releases iOS 26.7 With Security Fixes
Alongside iOS 27, Apple today released iOS 26.7, an update to the existing iOS 26 software. Users who check for new software will see iOS 26.7 as the default update, with iOS 27 listed as an option at the bottom of the Software Update interface. According to Apple's release notes, iOS 26.7 includes security fixes, but it does not have any other features. Apple will eventually show iOS 27 as the main update for the iPhone, but that likely won't happen for a few weeks.
Investors Purchase High Volume of Call Options on Dave & Buster's Entertainment (NASDAQ:PLAY)
Dave & Buster's Entertainment, Inc. (NASDAQ:PLAY - Get Free Report) was the target of unusually large options trading activity on Monday. Stock investors purchased 11,361 call options on the stock. This is an increase of 345% compared to the typical daily volume of 2,551 call options.
Kennedy Center board to propose new options for honoring Trump, according to court filing
The document proposes 10 options for adding the president's name to the building's exterior.
fundivi Expands Small Business Access To Capital Through Hybrid Lending Model
BROOKLYN, NY, Sept. 14, 2026 (GLOBE NEWSWIRE) -- fundivi combines direct in-house lending with a vetted partner network and cash-flow-based underwriting to widen approval options for small and mid-sized businesses nationwide. fundivi, a Brooklyn, New York-based business funding platform, is expanding small business access to capital through a hybrid lending model that pairs direct in-house financing with a vetted network of funding partners. The approach allows business owners to submit a single
Harkin Institute, Anawim Housing launch housing accessibility initiative
The Harkin Institute for Public Policy and Citizen Engagement at Drake University and Anawim Housing have launched Affordable Access Des Moines, a collaboration aimed at integrating universal accessibility into the design and construction of affordable housing in Des Moines. The initiative, which also includes partners Hubbell Realty and Simonson Associates, will develop and test options…
11 Fan-Favorite Shows That Still Have New Seasons Coming Out in 2026
When it comes to deciding what to watch, there are a lot of options for great TV shows. And there are still even more returning shows coming our way. Here, 11 fan-favorite shows that still have new seasons coming in 2026, from 'Hunting Wives' to 'Emily in Paris.'
Report: Ole Werner not interested in Gladbach job
Ole Werner is reportedly not an option to become the next Borussia Mönchengladbach head coach following the departure of Eugen Polanski. According to Bild, the timing of a move to Gladbach does not ...
Women’s Health Center of West Virginia launches campaign promoting abortion pills
A women’s clinic has launched an ad campaign letting residents know that despite the state’s near total ban on abortion, they still have options.
iPhone Duo Has a Hidden Display Setting for Case Compatibility
Apple's new iPhone Duo has a special option in its display settings that adds a narrow black border to the left side of the screen. Blogger Nicolas Lellouche discovered the setting in the Display & Brightness menu during his hands-on time with the device shortly after Apple's iPhone event stream last week.
How to Watch Broncos Games Without Cable in 2026
Just because you don’t have cable doesn’t mean you have to miss out on the fun of live sports. That includes any and every Denver Broncos game this season.Your options for streaming will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your […] The post How to Watch Broncos Games Without Cable in 2026 appeared first on HEAVY.
Liverpool want deal for £30m Italian midfield sensation
Liverpool are eyeing potential midfield upgrades.The Reds declined to add a new midfield option in the summer transfer window. Money was instead spent elsewhere - leaving Andoni Iraola relying on the ...
How to Watch Lions Games Without Cable in 2026
Looking to watch Detroit Lions games but you don’t have cable? You’re in the right place.Your options will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your situation or location, we have the full rundown on how you can stream any Lions […] The post How to Watch Lions Games Without Cable in 2026 appeared first on HEAVY.
How to Watch Bears Games Without Cable in 2026
Whether you’re in or out of market, you can still easily watch Chicago Bears games without cable in 2026Your options will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your situation or location, we have the full rundown on how you can […] The post How to Watch Bears Games Without Cable in 2026 appeared first on HEAVY.
Manchester United tracking attacking prodigy amid interest from Europe’s elite
Manchester United are keeping tabs on Norwegian wonderkid Gabriel Rajkovic, while Alejandro Balde could still emerge as an option for the Premier League giants in the coming months.According to TEAMta...
Bone Health Without the Hype
I am at the Australasian Menopause Society meeting and we had a fantastic lecture on Bone Health on Day 2, called, “Everything you need to know about bones - except the boring bits!” Spoiler alert, there were no boring bits. The lecture was given by Dr. Amanda Beech, who is a senior staff specialist in Obstetric Medicine and Endocrinology at the Royal Hospital for Women, where she is director of the Bone Density Unit. I want to summarize my top 10 take-aways for you. Share Osteoporosis is a disease of low bone mass, disruption of bone microarchitecture, and fragility of the skeleton. It is a silent disease…until someone develops a fracture. The diagnosis of osteoporosis is based on either fragility/minimal trauma fractures or a T-score of less than -2.5 on a DXA (Dual-Energy X-ray Absorptiometry) or bone scan. It is important to recognize that about 50% of minimal trauma fractures occur when women have low bone mass (often referred to as osteopenia), but not osteoporosis. This tells us that bone strength is more complicated than a number on a DXA report. I am going to add a little here that wasn’t in the talk (one can only include so much in 25 minutes), as many women might read the above paragraph and think, “Shouldn’t we be treating everyone with low bone mass if this is when 50% of the fractures occur?” Many fractures happen for women with low bone mass because there are so many women with low bone mass –it is a statement about the population on a whole, not about the fracture risk of low bone mass. For you as an individual, bone density is only one component of fracture risk and many women with lower bone mass will not have a significantly elevated fracture risk. This is why individualized risk assessment matters. Subscribe We build bone in our teens and twenties, and by the time we are about thirty we have reached peak bone mass. This is why, when we discuss risk factors for osteoporosis, it is important to consider factors that might have affected us in our teens and twenties when we were actively building bone, such as nutritional restriction/energy imbalance. It is important to ask women about a history of eating disorders, and for those with such a history, getting a bone scan in perimenopause or at age 50 is likely warranted. (This image below isn’t from the talk, but is similar to one that was). Bone mass is relatively stable until about two years before the final menstrual period, and perimenopause marks a time of rapid bone loss for women. Using urinary markers of bone loss we know that the time of significantly accelerated bone loss starts about 1 year before the final period and ends about 2 years after the final period. The Study of Women’s Health Across the Nation (SWAN) shows that over the menopause transition women lose an average of 10.6% of the bone at their lumbar spine and 9.1% at the femoral neck While this wasn’t covered in the lecture, I want to add that the rapid bone loss during perimenopause is clearly related to more than estradiol, because during this time estradiol levels can be erratic and not uniformly low. Bone loss during perimenopause is likely a multi-hormone event. For example, rising FSH (follicle stimulating hormone) tracks with bone loss better than estradiol, and there is evidence that FSH may act directly on bone. While decreased estrogen matters, there is clearly more going on. FSH and bone is an active area of research. Subscribe Screening for osteoporosis was recommended fairly broadly before age 65, and was taken from the “Practitioner’s Toolkit for Managing Menopause,” from Monash University. Here is a screenshot from the toolkit that was used as a slide: I am going to add a little bit more about body weight here for clarification. Low body mass (typically 152.1 lb): 0 points (risk neutral) 60–69 kg (132.3–152.1 lb): 3 points (adds some risk)
Roma send Salah-Eddine to Panathinaikos with option to buy
Roma have not yet finished their transfer campaign, as Sky Sport Italia report a deal is done for Anass Salah-Eddine to join Panathinaikos on loan with option to buy.The window might’ve closed alrea...
iPhone 18 Pro and iPhone 18 Pro Max Now Available to Pre-Order
Apple is now accepting pre-orders for the iPhone 18 Pro and iPhone 18 Pro Max through its online storefront and the Apple Store app. If you don't see the option to order, make sure to refresh until the store comes up. The app is often a quicker way to get a pre-order in. Pre-orders for the iPhone 18 Pro models are available in more than 65 countries and regions around the world. If you used "Get Ready" ahead of time, you'll be able to place an order with just a couple of taps.
Inter vs Udinese: Chivu Weighs Rotation Options
Federico Dimarco is closing in on a return to Inter’s matchday squad for Monday’s clash with Udinese at San Siro, with Cristian Chivu weighing several further changes to his starting XI following ...
Celestron StarSense Explorer DX 130AZ review
A sharp, wide-field and genuinely portable 130mm reflector whose phone-guided pointing makes star-hopping optional, offering stunning views of the solar system and brighter deep-sky objects.
Samsung S90H OLED TV Review: A More Affordable OLED Option for Bright Rooms
With excellent image quality and an anti-reflective filter that makes it a great choice for well-lit watching, the Samsung S90H is a great OLED TV.
Bengals get another option after Commanders' late release
A roster move somewhere else gives the Bengals another option to add help.
How to Lure the Spendy and the Thrifty? Bring On the ‘Barbell.’
Restaurant chains are trying to draw in both kinds of consumers by offering low-cost and more-premium options at the same time.
Dining, entertainment concept approved for the Lake Charles lakefront
The new concept is set to bringing 10 dining options to one venue.
Notre Dame is ready for Rice's offensive variety
Notre Dame's defense has spent time learning to be ready for Rice's use of the option and shotgun on offense.
Two iOS 27 Features Won't Be Ready for Monday's Launch
Two iOS 27 features need a little more time in testing and won't be shipping until a future update, even though they were present during the beta period. Suggestions in Messages conversations and the option to automatically fix compromised passwords with a tap will not be in the initial version of iOS 27, and will instead launch in a later version of iOS 27. Apple noted the delays on its iOS 27 page, as well as its iPadOS 27 and macOS Golden Gate pages as these are cross-platform features.
Fabrizio Romano confirms Liverpool cult hero agrees surprise deal
A surprise move is on the cards for a Liverpool cult hero. It's an exciting transformation for the Reds. Liverpool are finally saying goodbye to the Richard Hughes era and exploring their options to a...
The 5 College Football Games to Watch in Week Two
(#23)Missouri at Kansas 8 p.m., FOX (Friday) Missouri is trying to make it out of non-conference play unscathed while they await the return of star running back Ahmad Hardy. That could be a tough task for an early-season rivalry game. The Border War is by far the best option on Friday, and will have the […]
The 9 Best Snack Options to Support Your Gut Health
Experts break down the best food options for day’s smallest meal that won’t cause bloating or indigestion.
Vance? Rubio? DeSantis? Cruz? Republicans at Dallas convention ponder options for post-Trump leader
The vice president's speech solidified his status as a potential frontrunner, and President Donald Trump talked him up afterwards as a “very talented guy” who “did a very good job."
Carrick on forward options, Manchester derby and his own position
Manchester United boss Michael Carrick has been speaking to the media before Sunday's Premier League game against Manchester City at Old Trafford (kick-off 16:30 BST). Matheus Cunha and Benjamin Sesko both "bring different threats" to Manchester United, with Carrick saying who is picked is dependant "a little bit on the opposition and a little bit on the balance of our team and the spaces we want to attack".
India's NSE CEO says other business growth could curb weekly options' revenue share
National Stock Exchange of India's chief said on Friday that growth in its other businesses is likely to reduce the share of revenue generated by weekly options trading, as the country's largest bourse seeks a valuation of up to 4.42 trillion rupees ($46.26 billion) through its long-awaited IPO.
How Flex Pay Launch At Six Flags Entertainment (FUN) Has Changed Its Investment Story
Six Flags Entertainment introduced Flex Pay by Upgrade in September 2026, letting eligible guests buy Season Passes and other products of US$49 or more online and pay over time through fixed monthly installments, with immediate access to pass benefits after activation and no prepayment penalties. This financing option could influence how visitors budget for trips, with more spending potentially shifting toward recurring passes and planned visits rather than one off ticket purchases. This...
How to Watch 49ers Games Without Cable in 2026
Though it may not always seem as simple as it should be, it’s still fairly easy to watch every San Francisco 49ers game without cable in 2026.Your options will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your situation or location, we […] The post How to Watch 49ers Games Without Cable in 2026 appeared first on HEAVY.
Lions Secondary Put on Notice by Week 1 Fantasy Sleepers
The Detroit Lions‘ defense has a lot of questions entering the season. So, despite quarterback Tyler Shough being a lower-ranked fantasy football option in Week 1, he could end up being a great sleeper target. Moe Moton of Bleacher Report writes that Shough, along with his receiver Devaughn Vele, are two of the most underrated […] The post Lions Secondary Put on Notice by Week 1 Fantasy Sleepers appeared first on HEAVY.
What does future hold for Van Dijk and Alisson?
Alisson's deal expires at the end of the season and although Juventus were interested in the goalkeeper this summer, Liverpool had no intention of letting him leave. Liverpool are not short of options.
Shop the Best Cases for Your New iPhone 18 Pro or iPhone Duo
It's iPhone pre-order week, which means anyone looking to get the new iPhone 18 Pro or iPhone 18 Pro Max will likely be looking for new cases and protection for the smartphones. Below we're tracking all of the best case and screen protector options from the most popular accessory brands, including ZAGG, Nomad, and more. Note: MacRumors is an affiliate partner with some of these vendors.
Two Spanish options emerge for unwanted Liverpool forward Chiesa
Federico Chiesa’s chances of earning regular playing time at Liverpool are at an all-time low, but the latest reports on Thursday claim that there is still interest in the former Italy international...
Injury-hit Cardiff weighing up free-agent options
Cardiff City are continuing to monitor the free-agent market as an injury-hit squad leaves head coach Brian Barry-Murphy short of options.
Global library trends report on AI, open science, future of libraries
The Pulse of the Library 2026 report surveyed 1,800+ academic, national and public libraries globally on future of the library and trends including the pace of AI adoption
Fit after 14 months out - Weiser an option for Bremen
Bremen (dpa) - Werder Bremen's Mitchell Weiser is closing in on his comeback, 14 months after a serious knee injury. The 32-year-old full back could return to Bremen's matchday squad on Saturday away to his youth side Cologne.
Packers get clear Aaron Banks update ahead of Vikings opener
The Green Bay Packers still view Aaron Banks as the leading option at left guard for Week 1, but his availability remains uncertain because of his knee injury. Banks is set to take part in Wednesday’s practice on a limited basis after the issue restricted his involvement throughout much of training camp and the preseason. [...]
Health questions? “Ask Away.” PC Health™ launches new “Built in Canada for Canadians” AI-powered health chat
The only AI-powered chat created expressly for all Canadians, connecting people to trusted, practical information, and appropriate care optionsPersonalized answers to health questions that Canadians can trustBacked by more than 1,000 Canadian clinical sourcesAll health chat conversations are stored in Canada and are protected under Canadian privacy laws BRAMPTON, Ontario, Sept. 10, 2026 (GLOBE NEWSWIRE) -- Today, PC Health™ launched PC Chat™, a free AI-powered health tool built in Canada, based
Treasury Must Keep Collecting and Preserving Business Owner Info
The Treasury Department’s decision to stop collecting certain business ownership information and delete information already collected will hinder fraud investigations by the IRS and other federal agencies, columnist Danny Werfel writes.
Dana White Reveals Top 2 Potential Opponents for Ilia Topuria
UFC president Dana White revealed who the top two potential opponents for former UFC lightweight champion Ilia Topuria are.Gaethje defeated Ilia Topuria via fourth-round TKO in the main event of UFC Freedom 250 in June, and there has been some talk about a rematch between the two heated rivals.Another option could be Paddy Pimblett, another […] The post Dana White Reveals Top 2 Potential Opponents for Ilia Topuria appeared first on HEAVY.
Digital health AI adoption is outpacing the policies covering it
Beazley survey finds a gap between what executives fear and what actually drives claims
Is Six Flags Entertainment (FUN) A Bargain On Its New Flex Pay Launch?
Six Flags Entertainment (FUN) just rolled out Flex Pay by Upgrade, a buy now pay later style option for online purchases from $49, including Season Passes and other qualifying products. For investors watching Six Flags Entertainment, the latest product moves are coming against a tougher backdrop, with the share price down 41.4% over the past 90 days and the 1 year total shareholder return declining 34.0%. This points to fading momentum and a market that is pricing in higher risk, even as...
Closing health workforce gaps for emergency response: the Western Pacific steps up
Over 100 health emergency experts from 56 institutions across 21 countries in the World Health Organization (WHO) Western Pacific Region who are part of the Global Outbreak Alert and Response Network (GOARN) concluded their annual regional partners’ meeting with a commitment to bridge gaps in emergency workforce capacities and advance regional emergency readiness and resilience.Co-hosted by WHO and the Korea Disease Control and Prevention Agency in the Republic of Korea, the two-day event aimed to strengthen the Region’s collective ability to detect, prepare for and respond to health emergencies.Partners mapped capacities and priority technical gaps across the Region — including cybersecurity and critical infrastructure resilience; water, sanitation and hygiene (WASH) and environmental health; biological emergencies, nuclear emergencies, and nuclear and radiological security.The result: a renewed commitment to close these gaps by working together through shared expertise and coordinated action. Advancing the Global Health Emergency CorpsReflective of regional solidarity and partnerships in action, GOARN – which is coordinated globally by WHO - enables a stronger, better-connected emergency health workforce that is ready to surge wherever and whenever requested by WHO Member States.This year alone, GOARN partners across the Western Pacific have supported nine experts on six missions - from measles outbreaks in Viet Nam to HIV outbreak response in Fiji - providing surge support in epidemiology, surveillance and clinical case management.Photo: Participants at the Global Alert and Response Network (GOARN) Partners Meeting 2026. Credit: KDCA/Shin Dong Myoung“GOARN partners across the Western Pacific and globally have repeatedly demonstrated the power of what we can do collectively, when we join forces, share expertise and build on each other’s strengths,” noted Dr Gina Samaan, WHO Regional Emergency Director for the Western Pacific, in her opening remarks at the gathering. “Let us continue to forge long-term partnerships grounded in mutual respect that will protect the Region for generations to come. We are smarter, faster and infinitely stronger when we work together,” she added.Reiterating Dr Samaan's call, Dr Seung-kwan Lim, Commissioner of the Korea Disease Control and Prevention Agency, emphasized the value of GOARN: “The Republic of Korea is pleased to stand alongside our regional partners in building an emergency workforce that is ready and resilient. GOARN turns national expertise into regional readiness - catalysing national strengths into collective resilience.”GOARN advances the Global Health Security Action Framework (GHEC) initiative by “convening, connecting and capacitating” regional leaders and surge workforce – “the three Cs”. Years of GOARN leadership and outbreak response training programmes have cultivated a deep bench of fit-for-purpose, seasoned outbreak response experts and forged an alumni network of emergency leaders worldwide. The Western Pacific network alone has now grown to 94 partner institutions across 19 countries. Photo: Participants at the Global Alert and Response Network (GOARN) Partners Meeting 2026. Credit: KDCA/Shin Dong Myoung Putting partnerships into practiceDuring the Regional Partners’ Meeting, health experts identified and catalogued the technical expertise currently available across the Western Pacific Region, so that the right skills could be better matched quickly to needs wherever emergencies occur.Three priority areas emerged for further strengthening:Cybersecurity and critical infrastructure resilience - protecting essential systems, including healthcare networks, from digital disruptions.Water, sanitation and hygiene (WASH) and environmental health - reflecting the ongoing nexus between climate change and health.Biological emergencies, nuclear emergencies, and nuclear and radiological security - requiring specialized technical capability that remains limited across many national response systems.Meeting participants reaffirmed their commitment to strengthening workforce capacities in the Region, with a particular focus on these three areas, and to working collectively to better prepare the Western Pacific for the next health emergency.Photo: Dr Gina Samaan, WHO Regional Emergency Director for the Western Pacific, delivers opening remarks at the Global Alert and Response Network (GOARN) Partners Meeting 2026. Credit: KDCA/Shin Dong Myoung“GOARN is truly turning preparedness into action - giving our Region the surge capacity it needs for fast, coordinated response when it matters most - and building more resilient health systems along the way,” said Dr Samaan. “As health emergencies mount in this age of permacrisis, emergency preparedness and response must be woven into the fabric of health. This is not an option, but an imperative as we seek to achieve health for all.”____ About GOARNThe Global Outbreak Alert and Response Network (GOARN), coordinated by the World Health Organization since 2000, strengthens global health security by advancing preparedness for and response to public health emergencies. The network brings together more than 390 institutions, including national public health agencies, technical organizations and nongovernmental partners, to support coordinated international action during outbreaks and other health emergencies. There are 94 GOARN partners in the Western Pacific Region (as of August 2026), accounting for approximately 25% of global partners. For more information and media interviews, please contact: WHO Western Pacific Communications: wprocom@who.intAra Johannes: johannesa@who.int
How to Watch Patriots Games Without Cable in 2026
No cable doesn’t mean you have to miss a single New England Patriots game in 2026.Your options will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your situation or location, we have the full rundown on how you can stream any Patriots […] The post How to Watch Patriots Games Without Cable in 2026 appeared first on HEAVY.
Apple Adds AppleCare One Family Plan for Up to Six People
Apple today announced AppleCare One Family, a new option for U.S. customers that extends AppleCare coverage to every eligible device across an Apple Family Sharing group of up to six people for one fixed monthly price. AppleCare One Family costs $49.99 per month and includes all of the same benefits as AppleCare+, such as coverage for accidental damage like drops and spills, battery replacement service, and priority support from Apple Experts.
How to Watch Seahawks Games Without Cable in 2026
The defending champion Seattle Seahawks will be must-watch TV in 2026. Fortunately, even if you don’t have cable, you can still easily watch them.Your options will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your situation or location, we have the full […] The post How to Watch Seahawks Games Without Cable in 2026 appeared first on HEAVY.
Sacramento drive-in hosts free movie night with kid-friendly options. What to know
Discounts on nachos, bounce houses and other activities will accompany six free movies at the West Wind theater’s movie night.
Healthy Living with USA Health: Enlarged Prostate Treatment Options
In this Healthy Living, we talk with Troy M. Sofinowski, M.D., an Endourologist at USA Health.
How to watch the US Open without cable today
Here's how to watch the US Open today, including TV channels and live streaming options.
Policy vs. Practice: Digitizing Mexico's Healthcare Ecosystem
Mexico's new digital health law mandates EHRs and telemedicine, but market and infrastructure gaps could slow real-world adoption.
Prisma Health to host free webinar on menopause
Prisma Health is offering a free webinar on Sept. 23 to help women better understand menopause, recognize common symptoms, and explore treatment options that can improve their quality of life.
New Business: Paradise Coffee owners bring grab-and-go options to Point Tiburon Plaza
Paradise Coffee at Point Tiburon Plaza in Tiburon sells Cubano sandwiches, breakfast burritos and bonbons from a Tiburon chocolatier.
Drew Anderson just gave Tigers a $10 million decision
Drew Anderson has gone from a flexible bullpen arm to a legitimate piece of Detroit’s rotation. Now the Tigers must determine whether that transformation is worth exercising his $10 million club option for 2027.
IMG_6723.jpeg
Good Day Cafe's burger and fish sandwich (pictured here) are great options in Oxford, Mississippi.
All New iPhone 18 Pro and 'iPhone Duo' Colors Leaked
Ahead of Apple's annual iPhone event at 10 a.m. Pacific Time today, Bloomberg's Mark Gurman has leaked all of the color options for the iPhone 18 Pro, iPhone 18 Pro Max, and the first-ever foldable iPhone named the iPhone Duo. iPhone 18 Pro and iPhone 18 Pro Max color options:Black Light Blue Burgundy Silver Burgundy has also been described as Dark Red or Dark Cherry.
Steelers holding leverage in Joey Porter Jr. contract talks
The Pittsburgh Steelers maintain crucial franchise tag options as negotiations with cornerback Joey Porter Jr. enter a critical pre-season stretch.
OneSkies Makes Business Class More Accessible
TAMPA, Fla., Sept. 09, 2026 (GLOBE NEWSWIRE) -- OneSkies, a travel service focused on premium international airfare, is helping U.S. travelers explore competitive business class flight options for long-haul trips to destinations across Europe, Asia, the Middle East and beyond. As travelers increasingly prioritize comfort on international journeys, business class is attracting interest beyond traditional corporate travel. Vacationers, entrepreneurs, couples, families and experienced travelers are
Bucs $14M Addition Expected to Have ‘Prominent’ Role
One of the tougher fantasy football backfields to decide is the Tampa Bay Buccaneers. While many will be debating between Bucky Irving and Kenneth Gainwell as the top option in fantasy, Greg Auman of Fox Sports weighed in with a strong case for Gainwell. Auman noted that Zac Robinson has a chance to significantly improve […] The post Bucs $14M Addition Expected to Have ‘Prominent’ Role appeared first on HEAVY.
The 20 colleges with the best food, campus dining
Niche identified the top US colleges for campus food options, based on student reviews and meal plan costs.
Besxar is building an orbital semiconductor factory, one SpaceX rocket at a time
If you want to manufacture in space—and bring the products back again—there's a limited set of options: Wait to go to the International Space Station, or
Accenture and Google Cloud establish Gemini Enterprise Business Group
The partnership aims to accelerate enterprise adoption of agentic AI, offering expanded industry expertise and technical resources.
AT&T Business and Amazon Leo form strategic partnership
AT&T Business and Amazon Leo have agreed to bring broadband services to AT&T Business customers nationwide, making AT&T is the first major U.S. telecom provider to offer converged connectivity solutions that include Amazon Leo’s low Earth orbit (LEO) satellite services. With the agreement, AT&T Business customers have multiple access connectivity options, which the company said […]
NEA partner Aaron Jacobson weighs in on open versus closed
Big Tech may be grabbing attention for its powerful new models, but investors like NEA's Aaron Jacobson want companies to explore their options.
Here is what to do if healthcare costs are eating into your raises
An insurance executive explains how soaring healthcare costs eat into raises, and how workers should discuss alternative options with their company.
UTA health center to hold kickoff for free flu shots Wednesday
The clinic is next to Brazos Park, and appointments are optional but encouraged.
Louisville opens first mental health crisis center
Louisville’s first mental health crisis center is now open, offering walk-in help and a new option beyond jail or the emergency room.
Arsenal youngster in international tug-of-war
Ceadach O’Neill’s international future remains unresolved, with Northern Ireland and the Republic of Ireland both still possible options for the Arsenal youngster.Photo by Cameron Smith/Getty Imag...
At rally to save Academy of Natural Sciences museum, protesters urge Drexel to 'act like it's an emergency'
Local lawmakers and scientists outlined several options to preserve the museum, which is due to close Sept. 30.
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
London, UK, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Sky Blue Cinematix , the entertainment and brand-integration division of Sky Blue Media Group, to...
New business park latest in Painesville’s mounting development
After years of bringing new housing and entertainment options to the Lake County city, moves are now underway to clear the way for industrial and commercial uses.
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Norman Rock Creek Entertainment District faces lawsuit over tax increment financing
Norman's Rock Creek Entertainment District is a $1 billion project set to open in 2028, including a multipurpose performance venue, restaurants, retail space, office development, a hotel, and multiple housing options.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
LMH Health announces participation in Astra Health to expand access, improve care and reduce healthcare costs
We are pleased to announce that LMH Health is one of five independent Kansas health systems joining together to form Astra Health, a new regional healthcare collaboration designed to improve patient care, strengthen access to specialty services, and deliver more affordable healthcare options for employers and communities across Kansas. By working together, participating health systems […]
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
Cardinals’ 3rd-base Picture Coming Into Focus for 2027
After the offseason exits of Nolan Arenado and Brendan Donovan from the Cardinals organization, it opened up a pathway for Nolan Gorman to take advantage of everyday opportunities. However, that hasn’t quite come to fruition. The Cardinals optioned Gorman to Triple-A Memphis in June and put him through a vigorous rework of his swing and […]
The 5 Best Dinner Options for Your Gut Health
Your digestion and sleep are closely linked. Here, experts break down the best dinner food options that will support your gut health and a good night's rest.
Richarlison running out of options for Tottenham exit
Tottenham and forward Richarlison are running out of options for an amicable conclusion to a messy transfer saga. Richarlison started Spurs’ opening-day loss at Brentford on August 22, but was left out of the club’s 25-man Premier League squad list named by Roberto De Zerbi on Thursday.
NFL Expert Makes Bold Prediction for Rams TE Terrance Ferguson
The Los Angeles Rams could have another offensive weapon ready to emerge in 2026, and Terrance Ferguson has received a bold prediction ahead of his second NFL season. The young tight end is being projected to catch eight touchdown passes as the Rams look for another reliable option in their high-powered passing attack. Ferguson showed […] The post NFL Expert Makes Bold Prediction for Rams TE Terrance Ferguson appeared first on Gridiron Heroics.